Brigitte Askonas

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Brigitte Askonas is affiliated with the following schools: McGill University, Wellesley College, University of Cambridge

Brigitte Askonas's AcademicInfluence.com Rankings

Brigitte Askonas

Biology

#2256

World Rank

#3610

Historical Rank

Immunology

#160

World Rank

#168

Historical Rank

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Biology

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According to Wikipedia, Brigitte Alice Askonas was a British immunologist and a visiting professor at Imperial College London from 1995. Education Brigitte Askonas was born to Czechoslovak parents, Jewish converts to Catholicism, who fled Austria after the Nazi takeover. Vienna-born Askonas studied biochemistry at McGill University and carried out her postgraduate work in the school of biochemistry at the University of Cambridge where she was a student of Girton College, Cambridge.

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Brigitte Askonas's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus (1988) (477)
Isoelectric Focusing in Polyacrylamide Gel and its Application to Immunoglobulins (1968) (470)
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. (2008) (446)
Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed- type hypersensitivity reactions (1981) (348)
Immunogenicity of Antigen-Containing Ribonucleic Acid Preparations from Macrophages (1965) (289)
Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro (1989) (278)
Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo. (1986) (276)
HLA restriction of cell-mediated lysis of influenza virus-infected human cells (1977) (256)
Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses (1977) (227)
Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell (1982) (215)
Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glycoprotein (G), expressed by vaccinia virus recombinants. (1986) (204)
Domain interactions of H–2 class I antigens alter cytotoxic T-cell recognition sites (1984) (195)
Activation of mouse complement by different classes of mouse antibody. (1979) (194)
Cross‐protection and cross‐reactive cytotoxic T cells induced by influenza virus vaccines in mice (1980) (186)
One cell-one immunoglobulin. Origin of limited heterogeneity of myeloma proteins. (1970) (183)
Clearance of persistent respiratory syncytial virus infections in immunodeficient mice following transfer of primed T cells. (1987) (167)
Selection of a single antibody-forming cell clone and its propagation in syngeneic mice. (1970) (166)
Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A‐strain specificity while infected cells confer cross‐reactive cytotoxicity (1977) (146)
PERSISTENCE OF IMMUNOGENICITY OF ANTIGEN AFTER UPTAKE BY MACROPHAGES (1968) (146)
Purified influenza virus nucleoprotein protects mice from lethal infection. (1987) (145)
Suppressor cells and loss of B-cell potential in mice infected with Trypanosoma brucei. (1977) (141)
Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo. (1996) (135)
Enhanced recognition of a modified peptide antigen by cytotoxic T cells specific for influenza nucleoprotein (1988) (133)
Cytotoxic T cell specificity for respiratory syncytial virus proteins: fusion protein is an important target antigen. (1987) (132)
Formation of specific antibodies and gamma-globulin in vitro; a study of the synthetic ability of various tissues from rabbits immunized by different methods. (1958) (129)
The immune response of mice to antigen in macrophages. (1968) (120)
The 22,000-kilodalton protein of respiratory syncytial virus is a major target for Kd-restricted cytotoxic T lymphocytes from mice primed by infection (1990) (118)
Influenza virus‐specific cytotoxic T cells in man; induction and properties of the cytotoxic cell (1978) (114)
A role of macrophages in the stimulation of immune responses by adjuvants. (1969) (112)
Cytotoxic T-cell response to respiratory syncytial virus in mice (1985) (112)
The human cytotoxic T cell response to influenza A vaccination. (1981) (110)
Rapid recovery of lung histology correlates with clearance of influenza virus by specific CD8+ cytotoxic T cells. (1989) (107)
Senescence of an Antibody-forming Cell Clone (1972) (106)
Immunoglobulin M biosynthesis. Intracellular accumulation of 7S subunits. (1969) (93)
Biosynthesis of immunoglobulins: the separate classes of polyribosomes synthesizing heavy and light chains. (1967) (90)
Cell cooperation in antibody induction. The susceptibility of helper cells to specific lethal radioactive antigen (1971) (84)
Surface immunoglobulins of lipopolysaccharide‐stimulated spleen cells The behaviour of IgM, IgD and IgG (1977) (81)
The localization of antigen in relation to specific antibody-producing cells. I. Use of a synthetic polypeptide [(T,G)-A--L] labelled with iodine-125. (1966) (78)
Macrophages as mediators of immunosuppression in murine African trypanosomiasis. (1985) (77)
Electron microscopic studies of mouse immunoglobulin M; structure and reconstitution following reduction. (1970) (76)
Macrophage activation in murine African trypanosomiasis (1983) (71)
A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. (1961) (70)
Immunological B memory in thymus deprived mice. (1972) (67)
Macrophages as primary target cells and mediators of immune dysfunction in African trypanosomiasis (1981) (66)
Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line (1980) (66)
Membrane fractions of trypanosomes mimic the immunosuppressive and mitogenic effects of living parasites on the host (1979) (66)
Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations-during trypanosomiasis. (1979) (64)
Correlation of grain counts with radioactivity (125I and tritium) in autoradiography. (1966) (63)
Intrinsic immunosuppressive activity of different trypanosome strains varies with parasite virulence (1980) (62)
African trypanosomiasis alters prostaglandin production by murine peritoneal macrophages. (1984) (60)
ENZYMATICALLY PRODUCED SUBUNITS OF PROTEINS FORMED BY PLASMA CELLS IN MICE (1962) (60)
Cytotoxic T-memory cells in virus infection and the specificity of helper T cells. (1982) (59)
Dominance of a Cell Clone Forming Antibody to DNP (1972) (58)
Sites of antibody production in the guinea-pig; the relation between in vitro synthesis of anti-ovalbumin and gamma-globulin and distribution of antibody-containing plasma cells. (1956) (55)
Role of macrophages in the immune response. (1968) (54)
Do L3T4+ T cells act as effector cells in protection against influenza virus infection. (1987) (54)
Biosynthesis of Immunoglobulins. Free Light Chain as an Intermediate in the Assembly of γG-Molecules (1966) (54)
The source of antibody globulin in rabbit milk and goat colostrum. (1954) (52)
Helper T cell recognition of respiratory syncytial virus in mice. (1988) (51)
Six unrelated HLA-DR-matched adults recognize identical CD4+ T cell epitopes from influenza A haemagglutinin that are not simply peptides with high HLA-DR binding affinities. (1998) (50)
Factors affecting the propagation of a B Cell Clone forming antibody to the 2,4‐dinitrophenyl group (1972) (50)
The use of organic solvents at low temperature for the separation of enzymes; application to aqueous rabbit muscle extract. (1951) (50)
Biosynthesis of immunoglobulins. (1972) (49)
The significance of multiple antibody components in serum of immunized rabbits. (1960) (48)
Diversity in the biological properties of anti‐influenza cytotoxic T cell clones (1983) (48)
Induction of influenza A virus cross-reactive cytotoxic T cells by a nucleoprotein/haemagglutinin preparation. (1985) (47)
Carrier specificity and the allogeneic effect in mice (1972) (46)
Cytotoxic T Cells in Influenza Infection (1988) (46)
The differentiation function of T cell‐replacing factor in nu/nu spleen cell cultures (1974) (46)
Diversity of antibodies to cross‐reacting nitrophenyl haptens in inbred mice (1974) (45)
Production of interferons during experimental African trypanosomiasis. (1983) (44)
Formation of antibody by isolated perfused lungs of immunized rabbits: the use of [14C]amino acids to study the dynamics of antibody secretion. (1958) (42)
Trypanosome‐induced suppression of anti‐parasite responses during experimental African trypanosomiasis (1980) (42)
Interaction of African trypanosomes with the immune system. (1984) (41)
Assembly of immunoglobulin M. Blocked thiol groups of intracellular 7S subunits. (1971) (41)
Trypanosoma brucei infection in nude mice: B lymphocyte function is suppressed in the absence of T lymphocytes (1979) (40)
Aspects of control of protein synthesis in normal and regenerating rat liver. I. A cytoplasmic RNA-containing fraction that stimulates amino acid incorporation. (1963) (39)
Identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicates the existence of potential asymptomatic infections. (2012) (39)
Human CD4+ T-cell repertoire of responses to influenza A virus hemagglutinin after recent natural infection (1995) (39)
Incubation of trypanosome-derived mitogenic and immunosuppressive products with peritoneal macrophages allows recovery of biological activities from soluble parasite fractions (1982) (38)
Influenza virus infection of mouse lymphoblasts alters the binding affinity of anti‐H‐2 antibody: Requirement for viral neuraminidase (1979) (38)
Murine trypanosomiasis: cellular proliferation and functional depletion in the blood, peritoneum, and spleen related to changes in bone marrow stem cells. (1980) (38)
Observations concerning the heterogeneity of ovine thyroglobin. (1959) (37)
Monoclonal antibodies to hemagglutinin and to H‐2 inhibit the cross‐reactive cytotoxic T cell populations induced by influenza (1980) (37)
Identification of residues necessary for clonally specific recognition of a cytotoxic T cell determinant. (1989) (37)
The localization of antigen in lymph nodes and its relation to specific antibody-producing cells. II. Comparison of iodine-125 and tritium labels. (1967) (37)
Murine cytotoxic T cells specific to respiratory syncytial virus recognize different antigenic subtypes of the virus. (1986) (37)
Inhibition of mixed leukocyte culture by anti‐idiotypic antibodies (1975) (36)
Amplification of B cell clones forming antibody to the 2,4‐dinitrophenyl group (1972) (36)
On the origin of the multiple forms of rabbit γ-globulin (1956) (36)
Quantitation of influenza virus antigens on infected target cells and their recognition by cross-reactive cytotoxic T cells (1980) (36)
Trypanosomiasis leads to extensive proliferation of B, T and null cells in spleen and bone marrow. (1978) (36)
Deficiency of erythrocyte glucose‐6‐phosphate dehydrogenase in Greek populations (1963) (35)
Human CD4+ T-cell recognition of influenza A virus hemagglutinin after subunit vaccination (1996) (35)
Influenza-specific cytotoxic T-cell recognition is inhibited by peptides unrelated in both sequence and MHC restriction. (1989) (35)
Effect of Thyroxine on Creatinephosphokinase Activity (1951) (34)
Formation of Bence-Jones protein and myeloma protein in vitro by the plasma-cell tumour MPC-2. (1961) (32)
The homogeneous-gamma-G-immunoglobulin produced by mouse plasmacytoma 5563 and its subsequent heterogeneity in serum. (1967) (32)
Biosynthesis of immunoglobulins on polyribosomes and assembly of the IgG molecule (1966) (32)
Macrophages bearing hapten‐carrier molecules as foci inducers for T and B lymphocyte interaction (1974) (32)
Serum Antibody and γ-Globulin in Baby Rabbits after Transfer of Ribonucleoprotein from Adult Rabbits (1959) (31)
Biosynthesis of proteins. 3. Precursors in the synthesis of casein and beta-lactoglobulin. (1955) (30)
Several proliferate phases precede maturation of IgG-secreting cells in mitogen-stimulated cultures (1976) (30)
Influenza peptide-induced self-lysis and down-regulation of cloned cytotoxic T cells. (1990) (29)
IgG response in vitro. I. The requirement for an intermediate responsive cell type (1976) (28)
Competition between unrelated peptides recognized by H-2-Kd restricted T cells. (1988) (27)
Balanced Synthesis of Light and Heavy Chains of Immunoglobulin G (1967) (26)
ENZYMATICALLY PRODUCED SUBUNITS OF PROTEINS FORMED BY PLASMA CELLS IN MICE (1962) (25)
Viral recognition by influenza A virus cross‐reactive cytotoxic T (Tc) cells: The proportion of Tc cells that recognize nucleoprotein varies between individual mice (1986) (25)
Control of immune interferon release by cytotoxic T-cell clones specific for influenza. (1985) (25)
An Investigation of Closely Related Gamma-Myeloma Proteins and Normal Mouse Gamma-Globulin by Partial Enzymic Degradation and Starch-Gel Electrophoresis (1961) (24)
Biosynthesis and Assembly of Immunoglobulin G (1967) (24)
Murine CD4+ T cell clones vary in function in vitro and in influenza infection in vivo (1990) (23)
Influenza virus-specific T cells lead to early interferon gamma in lungs of infected hosts: development of a sensitive radioimmunoassay. (1989) (23)
Dendritic cells as targets for cytotoxic T lymphocytes. (1997) (22)
The biosynthesis of proteins. II. Synthesis of milk proteins by the goat. (1954) (21)
Mouse peritoneal cells: their ability to elicit or produce antibody after exposure to antigen. (1968) (20)
Interchain disulphide-bond formation in the assembly of immunoglobulin G. Heavy-chain dimer as an intermediate. (1968) (20)
Crystallization of goat β-lactoglobulin (1954) (20)
Class I MHC molecules rather than other mouse genes dictate influenza epitope recognition by cytotoxic T cells (2004) (19)
Dual pathway of B lymphocyte differentiation in vitro (1976) (17)
Interference in general immune function by parasite infections; African trypanosomiasis as a model system (1984) (16)
H-2 expression by lymphoid cells of different mouse strains: quantitative interaction of H-2 with monoclonal antibodies and their Fab fragments. (1981) (16)
Trypanosoma brucei Infection Stimulates Receptor-Mediated Phagocytosis by Murine Peritoneal Macrophages (1982) (15)
Differential reduction of interchain disulphide bonds of mouse immunoglobulin G. (1968) (14)
Analysis of affinity of monoclonal antibody responses by inhibition of plaque‐forming cells (1974) (14)
Monoclonal antibodies to influenza matrix protein: detection of low levels of matrix protein on abortively infected cells. (1980) (14)
Stimulation of cytotoxic T cells by liposomes containing influenza virus or its components. (1983) (14)
Heavy and light chains of a homogeneous immunoglobulin‐G (1969) (13)
The influence of electroconvulsive treatment on blood sugar, total number of leucocytes and lymphocytes. (1949) (12)
Clonal dominance and the preservation of clonal memory cells mediated by antigen-antibody. (1976) (11)
Non-specific factor replaces T cells in an IgG response to soluble antigens. (1977) (11)
Rapid changes in target cell lysosomes induced by cytotoxic T cells: indication of target suicide ? (1988) (11)
Antigenicity of the β-Chain of Human Hæmoglobin (1964) (11)
The life style of B cells--cellular proliferation and the invariancy of IgG. (1977) (10)
T-cell differentiation and effector functions. (1988) (10)
Production of γ1- and γ2-antiovalbumin by various lymphoid tissues of the guinea pig☆ (1965) (9)
Induction of Kb-restricted anti-influenza cytotoxic T cells in C57BL mice: importance of stimulator cell type and immunization route. (1985) (9)
Evidence for two T-helper populations with distinct specificity in the humoral response to influenza A viruses. (1982) (8)
Ageing and detoxication; studies in hippuric acid synthesis during psychoses of the involutional and old age group. (1945) (8)
Immunoglobulin heavy chain mRNA in mitogen‐stimulate B cells (1975) (8)
Immunoglobulin formation in B lymphoid cells. (1975) (8)
H-2 and viral haemagglutinin expression by influenza-infected cells; the proteins are close but do not cocap. (1982) (8)
The seeds of time; the life of sir macfarlane burnet (1993) (8)
Peptidases in Human Serum.∗ (1948) (8)
Loss of serological determinants does not affect recognition of H‐2Kk target cells by an influenza‐specific cytotoxic T cell clone (1983) (8)
Isoelectric focusing spectra of rabbit antibodies to Salmonella abortus-equi detected by anti-idiotypic sera. (1974) (8)
B-cell or T-cell immunity? (1982) (8)
T-cell mediated cytolysis: evidence for target-cell suicide. (1990) (8)
The Immune Response to Viral Infections (1989) (7)
On the origin of the multiple forms of rabbit gamma-globulin. (1956) (7)
Thymus dependence of the antibody response to Maia squinado haemocyanin in mice. (1972) (6)
Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells (2004) (6)
Immunoglobulin heavy chain mRNA in mitogen-stimulated B cells. (1975) (6)
The Distribution of Antigenic Groupings on Mouse Gamma-Globulin Molecules (1961) (6)
Influenza Vaccines [and Discussion] (1980) (6)
MHC and antigen presentation. (1989) (6)
T-Cell Cloning (1997) (5)
T cell mediated immunity in virus infection. (1987) (5)
Erratum: Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals (Journal of Clinical Investigation (2008) 118, 10, (3478-3490) doi:10.1172/JCI32460) (2012) (5)
Our immune defence against influenza. (1980) (5)
An influenza specific T-killer clone is restricted to H-2Ldand cross-reacts with Dkregion (2004) (5)
John Herbert Humphrey, 16 December 1915 - 25 December 1987 (1990) (4)
Failure to change the Antigenicity of Skin Grafts by Incubation with Allogeneic Ribonucleic Acid (1966) (4)
Biological Systems at the Molecular Level (1965) (4)
Influenza virus, a challenge to immunologists (1989) (4)
Low responder MHC alleles for Tc recognition of influenza nucleoprotein (2004) (4)
IgG anti-hapten antibody secretion in vitro commences after extensive precursor proliferation. (1977) (3)
Some molecular aspects of antibody formation. (1969) (3)
Nucleic acids and protein synthesis in animal tissues. (1957) (3)
NOTE ON HIPPURIC ACID SYNTHESIS IN SENILITY (1946) (3)
T-cells in respiratory syncytial virus (RSV) infection. (1989) (3)
Influenza Specific Cytotoxic T-Cell Clones and Immune Interferon (1985) (3)
Regulation of Antibody Production in Protozoal Infections (1982) (3)
Immunoglobulin synthesis and its induction in B-lymphoid cells. (1975) (2)
Vector-directed interleukin expression and infection (1987) (2)
MACROPHAGES AS MEDIATORS OF IMMUNOSUPPRESSION IN AFRICAN TRYPANOSOMIASIS (1982) (2)
Diversity in the interaction of influenza-A-specific cytotoxic T cells with H-2Kb mutant targets (2004) (2)
EVIDENCE FOR MESSENGER ACTIVITY OF ALIEN RIBONUCLEIC ACID IN CHICK CELLS. (1964) (2)
César Milstein CH. 8 October 1927 – 24 March 2002 (2005) (2)
The distribution of radioactivity in crystalline beta-lactoglobulin following the injection of [14C]valine and lysine into a goat. (1954) (2)
Immune dysfunction caused by African trypanosomes: effect on parasite specific responses and analysis of active fractions. (1980) (2)
Biosynthesis of milk proteins in the fasting goat. (1953) (2)
Workshop 39 – Immunoglobulin Biosynthesis (1971) (1)
The distribution of radioactivity in goat casein after injection of radioactive amino acids and its bearing on theories of protein synthesis. (1953) (1)
Glycine-creatine metabolism in its relationship to aging. (1947) (1)
Antibody formation in slices of granulomata produced by adjuvant. (1955) (1)
Immunoglobulin biosynthesis and its control. (1974) (1)
Cytotoxic T-cell recognition of influenza-infected target cells varies in different H-2k mouse strains (2004) (1)
Possible mechanism for target cell lysis by cytotoxic T‐cells (1984) (1)
Receptors for T-cell growth (1982) (1)
From protein synthesis to antibody formation and cellular immunity: a personal view. (1990) (1)
The generation of antibody diversity: A new look: Edited by A. J. Cunningham Academic Press; London, 1976 viii + 211 pages. £ 7.80 (1977) (1)
Control ofimmuneinterferon release bycytotoxic T-cell clones specific forinfluenza (1985) (1)
The Niels Jerne lecture. Influenza virus, a challenge to immunologists. (1989) (1)
John H. Humphrey (1915-1987). (1988) (1)
Immune Function in Infectious Diseases 1 (1981) (1)
Niels Kaj Jerne. 23 December 1911—7 October 1994. (1997) (1)
Crystallization of goat beta-lactoglobulin. (1954) (1)
A simplified method for the in vitro induction of IgG antibody in collagen coated dishes. (1978) (1)
ANTIGENICITY OF THE BETA-CHAIN OF HUMAN HAEMOGLOBIN. (1964) (1)
Cytotoxic t cell repertoire individual variation in influenza a virus nucleoprotein recognition (1986) (0)
Antigens lymphoid cells and the immune response: G. J. V. Nossal and G. L. Ada. Academic Press, New York, 1971. 344 pp. $17.50 (1972) (0)
Transphosphorylations Catalysed by Bivalent Metal Ions (2005) (0)
Cytotoxic T-Cell Response toRespiratory Syncytial VirusinMice (1985) (0)
Killer T-Cell Action: Killing or Induced Suicide? (1987) (0)
Protein synthesis in mammalian cells with particular reference to antibody formation (2010) (0)
Cytotoxic T Cells in Influenza: Their Role and Viral Specificities (1986) (0)
Great Britain Assembly of Immunoglobulin M BLOCKED THIOL GROUPS OF INTRACELLULAR 7 S SUBUNITS By (2005) (0)
Vaccines and infectious disease. (1982) (0)
Crystallization of Goat p-Lactoglobulin (2005) (0)
Lymphocytosis in Cells Recovered by Bronchoalveolar Lavage from Mice Infected with Human Respiratory Syncytial Virus (1987) (0)
HAZARD OF MIXING RELAXANT DRUGS. (1965) (0)
Immunopathology and Virus Infections (1994) (0)
Thymus dependence of the IgG response: role of T cells is restricted to non-specific rather than antigen-specific factors. (1979) (0)
Recognition of H-2Kk variant cells by an antiinfluenza cytotoxic T-cell clone. (1983) (0)
Killer T-Cell Cytolysis is Mediated by Activation of Target-Cell Ornithine Decarboxylase (1989) (0)
Selection ofaSingle Antibody-Forming CellCloneand ItsPropagation inSyngeneic Mice (1970) (0)
Production of gamma-1- and gamma-2-antiovalbumin by various lymphoid tissues of the guinea pig. (1965) (0)
Cloning of Antibody-Producing Cells in Vivo (1971) (0)
CONSTRICTING LESION OF RECTOSIGMOID (GRANULOMATOUS COLITIS). (1965) (0)
Phagocytic Cells: Immunobiology of the Macrophage . David S. Nelson, Ed. Academic Press, New York, 1976. xviii, 634 pp., illus. $39. (1977) (0)
Influenza virus infection of lymphoblasts alters binding affinity of anti h-2. Abstr. (1979) (0)
T-cell recognition of influenza-infected cells. (1981) (0)
Phagocytic cells. (1977) (0)

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