Brigitte Kieffer

Q: What Schools Are Affiliated With Brigitte Kieffer

Brigitte Kieffer is affiliated with the following schools: McGill University, University of Strasbourg, Vrije Universiteit Brussel

Brigitte Kieffer's AcademicInfluence.com Rankings

Brigitte Kieffer

Biology

#6204

World Rank

#8870

Historical Rank

Neuroscience

#1311

World Rank

#1356

Historical Rank

biology Degrees

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Biology

Brigitte Kieffer's Degrees

PhD Neurobiology University of Strasbourg
Doctorate Medicine University of Strasbourg

Why Is Brigitte Kieffer Influential?

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According to Wikipedia, Dr. Brigitte Kieffer is a French molecular neurobiologist known for her research of opiate receptors. Her areas of expertise include: molecular psychiatry, addiction, mood disorders, pain, and developmental disorders. Kieffer has international reputation in the field of opiate receptors, and has paved the way for better understanding of brain mechanisms involved in pain, mental illness, and drug addiction. She continues to pursue research and directs a team of over 300 people. Her discoveries have shed light on how substances like morphine or heroin can kill pain, and foster addiction.

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Brigitte Kieffer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene (1996) (1628)
The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. (1992) (941)
Reward processing by the opioid system in the brain. (2009) (794)
Exploring the opioid system by gene knockout (2002) (592)
Deficit in Attachment Behavior in Mice Lacking the µ-Opioid Receptor Gene (2004) (437)
Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain (2009) (436)
Opioid receptors: distinct roles in mood disorders (2013) (407)
Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses (2000) (403)
Opioids: first lessons from knockout mice. (1999) (401)
Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal (1998) (399)
mu-Opioid receptor knockout mice do not self-administer alcohol. (2000) (328)
Mu opioid receptor: a gateway to drug addiction (2004) (296)
Low‐affinity nerve‐growth factor receptor (P75NTR) can serve as a receptor for rabies virus (1998) (264)
Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides (1995) (262)
A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling* (2001) (257)
The delta opioid receptor: an evolving target for the treatment of brain disorders. (2011) (255)
Buprenorphine-Induced Antinociception Is Mediated by μ-Opioid Receptors and Compromised by Concomitant Activation of Opioid Receptor-Like Receptors (2003) (236)
Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors (2002) (234)
Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. (1995) (234)
Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. (2006) (234)
Attenuation of Nicotine-Induced Antinociception, Rewarding Effects, and Dependence in μ-Opioid Receptor Knock-Out Mice (2002) (217)
Quantitative autoradiographic mapping of μ-, δ- and κ-opioid receptors in knockout mice lacking the μ-opioid receptor gene (1997) (210)
A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks (2014) (200)
Correction for Simonin et al., RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia (2006) (193)
Opioid receptors: drivers to addiction? (2018) (186)
In Vivo Delta Opioid Receptor Internalization Controls Behavioral Effects of Agonists (2009) (181)
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. (2003) (177)
Opioid Tolerance–In Search of the Holy Grail (2002) (172)
Zinc Dynamics and Action at Excitatory Synapses (2014) (168)
Opioid receptors: From binding sites to visible molecules in vivo (2009) (167)
The Kappa Opioid Receptor: From Addiction to Depression, and Back (2014) (164)
Increased Ethanol Self‐Administration in δ‐Opioid Receptor Knockout Mice (2001) (162)
Opioid receptor genes inactivated in mice: the highlights (2002) (155)
The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. (1994) (152)
Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases. (2007) (151)
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia (2011) (146)
Ligand‐directed signalling within the opioid receptor family (2012) (145)
Role of Aromatic Transmembrane Residues of the -Opioid Receptor in Ligand Recognition (*) (1996) (143)
Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells (1998) (139)
Ligand-Directed Trafficking of the δ-Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance (2010) (138)
Anesthetic Potency and Influence of Morphine and Sevoflurane on Respiration in &mgr;-Opioid Receptor Knockout Mice (2001) (132)
The Involvement of the &mgr;-Opioid Receptor in Ketamine-Induced Respiratory Depression and Antinociception (2001) (130)
Identification of κ‐ and δ‐opioid receptor transcripts in immune cells (1995) (129)
Delta opioid receptors in brain function and diseases. (2013) (129)
Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons (2015) (126)
Generation and Characterization of Rgs4 Mutant Mice (2005) (123)
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. (2002) (122)
15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse (2014) (118)
Regulation of δ-Opioid Receptor Trafficking via μ-Opioid Receptor Stimulation: Evidence from μ-Opioid Receptor Knock-Out Mice (2003) (117)
Translating the Habenula—From Rodents to Humans (2017) (116)
Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice. (2005) (116)
Targeted Expression of Mu-Opioid Receptors in a Subset of Striatal Direct-Pathway Neurons Restores Opiate Reward (2014) (114)
Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine (2011) (112)
μ and δ Opioid Receptors Are Differentially Desensitized by the Coexpression of β-Adrenergic Receptor Kinase 2 and β-Arrestin 2 in Xenopus Oocytes* (1997) (111)
Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice (2013) (107)
Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn (2014) (106)
Neuropathic pain is enhanced in δ‐opioid receptor knockout mice (2006) (105)
The multiple facets of opioid receptor function: implications for addiction (2013) (103)
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit (2011) (102)
Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones (2003) (100)
Identification of a novel family of G protein‐coupled receptor associated sorting proteins (2004) (99)
Inflammatory pain is enhanced in delta opioid receptor‐knockout mice (2008) (98)
VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation (2014) (98)
Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". (2005) (97)
Delta-Opioid Receptors Are Critical for Tricyclic Antidepressant Treatment of Neuropathic Allodynia (2008) (97)
Opioid receptor random mutagenesis reveals a mechanism for G protein–coupled receptor activation (2003) (97)
Ligands for κ-Opioid and ORL1 Receptors Identified from a Conformationally Constrained Peptide Combinatorial Library* (1999) (97)
Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and mu-opioid receptor deficient mice. (2003) (95)
Increased ethanol self-administration in delta-opioid receptor knockout mice. (2001) (94)
Quantitative autoradiographic mapping of mu-, delta- and kappa-opioid receptors in knockout mice lacking the mu-opioid receptor gene. (1997) (93)
Mu and Delta Opioid Receptors Oppositely Regulate Motor Impulsivity in the Signaled Nose Poke Task (2009) (93)
Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches (2011) (91)
Autistic-Like Syndrome in Mu Opioid Receptor Null Mice is Relieved by Facilitated mGluR4 Activity (2014) (90)
Naloxone fails to produce conditioned place aversion in μ-opioid receptor knock-out mice (2001) (86)
Basal Signaling Activity of μ Opioid Receptor in Mouse Brain: Role in Narcotic Dependence (2004) (83)
The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice (2004) (81)
Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice. (2003) (79)
Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family. (1998) (76)
Constitutive Activation of the δ Opioid Receptor by Mutations in Transmembrane Domains III and VII* (1999) (75)
Nociceptin Receptor Impairs Recognition Memory via Interaction with NMDA Receptor-Dependent Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in the Hippocampus (2008) (73)
Deletion of the δ Opioid Receptor Gene Impairs Place Conditioning But Preserves Morphine Reinforcement (2011) (73)
Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. (2002) (72)
Decreased motivation to eat in µ‐opioid receptor‐deficient mice (2007) (72)
Big dynorphin as a putative endogenous ligand for the κ‐opioid receptor (2006) (72)
Differential involvement of the Mu and Kappa opioid receptors in spatial learning (2003) (71)
Dissociation of Analgesic and Hormonal Responses to Forced Swim Stress Using Opioid Receptor Knockout Mice (2006) (70)
Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain (2004) (67)
Neuropathic pain is enhanced in delta-opioid receptor knockout mice. (2006) (66)
Mu‐opioid receptors are involved in the tolerance to nicotine antinociception (2006) (66)
δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization (2012) (65)
Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist (2016) (65)
Quantitative autoradiographic mapping of opioid receptors in the brain of δ-opioid receptor gene knockout mice (2002) (63)
Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity (2008) (63)
Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons (2019) (63)
Expression of mu opioid receptor in dorsal diencephalic conduction system: New insights for the medial habenula (2014) (63)
Quantitative autoradiography of μ-,δ- and κ1 opioid receptors in κ-opioid receptor knockout mice (1999) (61)
Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice. (2011) (60)
Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice. (2001) (60)
Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. (2003) (60)
Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice (2003) (59)
Morphine Induces Desensitization of Insulin Receptor Signaling (2003) (59)
Basal and morphine‐evoked dopaminergic neurotransmission in the nucleus accumbens of MOR‐ and DOR‐knockout mice (2003) (58)
Molecular and biophysical mechanisms of arousal, alertness, and attention. Preface. (2008) (58)
Deletion of δ-opioid receptor in mice alters skin differentiation and delays wound healing (2006) (57)
Leukocyte opioid receptors mediate analgesia via Ca2+-regulated release of opioid peptides (2016) (57)
Differential impact of two critical respiratory centres in opioid‐induced respiratory depression in awake mice (2019) (55)
Detection of opioid receptor mRNA by RT-PCR reveals alternative splicing for the δ- and κ-opioid receptors (1997) (55)
Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence (2014) (55)
Reactivating addiction-related memories under propranolol to reduce craving: A pilot randomized controlled trial. (2016) (55)
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine. (2008) (55)
Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdala (2008) (54)
Impaired Hippocampus-Dependent and Facilitated Striatum-Dependent Behaviors in Mice Lacking the Delta Opioid Receptor (2013) (54)
Specific activation of the μ opioid receptor (MOR) by endomorphin 1 and endomorphin 2 (2000) (52)
Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures (2015) (52)
Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function (2016) (51)
Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome (2016) (51)
Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol (2017) (51)
Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization (2015) (50)
Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food (2017) (50)
The second extracellular loop: a damper for G protein–coupled receptors? (2005) (50)
Cannabinoid receptor and WIN 55 212‐2‐stimulated [35S]‐GTPγS binding in the brain of mu‐, delta‐ and kappa‐opioid receptor knockout mice (2003) (49)
Identification of kappa- and delta-opioid receptor transcripts in immune cells. (1995) (49)
Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation (2001) (49)
Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice (2005) (49)
Brain Regional Fos Expression Elicited by the Activation of μ- but not δ-Opioid Receptors of the Ventral Tegmental Area: Evidence for an Implication of the Ventral Thalamus in Opiate Reward (2008) (48)
κ-Opioid Receptors in the Central Amygdala Regulate Ethanol Actions at Presynaptic GABAergic Sites (2013) (47)
Deletion of μ- and κ-Opioid Receptors in Mice Changes Epidermal Hypertrophy, Density of Peripheral Nerve Endings, and Itch Behavior (2007) (47)
Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms (2009) (47)
Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula (2019) (46)
Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network (2012) (45)
Agonists activate Gi1α or Gi2α fused to the human mu opioid receptor differently (2002) (45)
Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play (2016) (45)
The rewarding properties of MDMA are preserved in mice lacking µ‐opioid receptors (2004) (45)
Endogenous nociceptin/orphanin‐fq in the dorsal hippocampus facilitates despair‐related behavior (2010) (43)
Opiates: basic mechanisms (2006) (42)
In Vivo Visualization of Delta Opioid Receptors upon Physiological Activation Uncovers a Distinct Internalization Profile (2012) (42)
Lack of dependence and rewarding effects of deltorphin II in mu‐opioid receptor‐deficient mice (2001) (42)
The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference (2007) (41)
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research (2018) (40)
Immunosuppression by δ-Opioid Antagonist Naltrindole: δ- and Triple μ/δ/κ-Opioid Receptor Knockout Mice Reveal a Nonopioid Activity (2001) (40)
The oxytocin analogue carbetocin prevents priming-induced reinstatement of morphine-seeking: Involvement of dopaminergic, noradrenergic and MOPr systems (2015) (40)
Cholecystokinin knock-down in the basolateral amygdala has anxiolytic and antidepressant-like effects in mice (2012) (39)
Sequence determination of a peptide fragment from electric eel acetylcholinesterase, involved in the binding of quaternary ammonium (1986) (39)
Characterization of δ, κ, and μ Human Opioid Receptors Overexpressed in Baculovirus-infected Insect Cells* (1997) (39)
Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice. (1999) (39)
Mouse Delta Opioid Receptors are Located on Presynaptic Afferents to Hippocampal Pyramidal Cells (2012) (38)
Overexpression of Dynamin Is Induced by Chronic Stimulation of μ- but Not δ-Opioid Receptors: Relationships with μ-Related Morphine Dependence (2000) (38)
The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models (2020) (38)
Influence of δ-Opioid Receptors in the Behavioral Effects of Nicotine (2012) (37)
Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn (2014) (37)
Mu opioid receptors in the medial habenula contribute to naloxone aversion (2019) (36)
A Novel Anxiogenic Role for the Delta Opioid Receptor Expressed in GABAergic Forebrain Neurons (2015) (36)
κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition (2018) (35)
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist. (2002) (35)
Expression of delta, kappa and mu human opioid receptors in Escherichia coli and reconstitution of the high-affinity state for agonist with heterotrimeric G proteins. (1999) (35)
Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior. (2007) (34)
Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks (2018) (34)
A molecular basis for opiate action. (1998) (34)
Induction of δ Opioid Receptor Function by Up-Regulation of Membrane Receptors in Mouse Primary Afferent Neurons (2005) (34)
Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains and spinal cords of mice deficient in the μ-opioid receptor gene (2002) (34)
Mu‐opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia (2010) (33)
Current strategies toward safer mu opioid receptor drugs for pain management (2019) (33)
μ-Opioid Receptors Selectively Regulate Basal Inhibitory Transmission in the Central Amygdala: Lack of Ethanol Interactions (2009) (32)
Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats (2018) (32)
GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors (2016) (32)
Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fear (2005) (32)
Deletion of delta-opioid receptor in mice alters skin differentiation and delays wound healing. (2006) (32)
Interaction of CRF and Kappa Opioid Systems on GABAergic Neurotransmission in the Mouse Central Amygdala (2015) (32)
Cues predicting drug or food reward restore morphine-induced place conditioning in mice lacking delta opioid receptors (2012) (31)
Presynaptic δ Opioid Receptors Regulate Ethanol Actions in Central Amygdala (2007) (31)
Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists (2019) (31)
Delta opioid mechanisms for ADL 5747 and ADL 5859 effects in mice : analgesia , locomotion and receptor internalization (2012) (30)
Neurofilament proteins and cAMP pathway in brains of μ-, δ- or κ-opioid receptor gene knock-out mice: effects of chronic morphine administration (2004) (30)
Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors (2018) (29)
Respiratory function in adult mice lacking the µ‐opioid receptor: role of δ‐receptors (2001) (29)
Mechanisms for the Regulation of State Changes in the Central Nervous System (2008) (28)
Functional and structural characterization of axonal opioid receptors as targets for analgesia (2016) (28)
CRF neurons in the ventral tegmental area control the aversive effects of nicotine withdrawal and promote escalation of nicotine intake (2014) (27)
The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice. (2012) (27)
μ-Opioid receptor activation prevents acute hepatic inflammation and cell death (2007) (27)
Enhanced humoral response in kappa-opioid receptor knockout mice (2003) (27)
RSK2 Signaling in Medial Habenula Contributes to Acute Morphine Analgesia (2012) (27)
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing (2018) (27)
Contrasting effects of μ opioid receptor and δ opioid receptor deletion upon the behavioral and neurochemical effects of cocaine (2004) (26)
Presynaptic delta opioid receptors regulate ethanol actions in central amygdala. (2007) (25)
Melanocortin receptors and δ‐opioid receptor mediate opposite signalling actions of POMC‐derived peptides in CATH.a cells (1998) (25)
Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking (2019) (25)
Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ Opioid Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via CLARITY (2020) (25)
μ-δ Opioid Receptor Functional Interaction: Insight Using Receptor-G Protein Fusions (2006) (24)
Opioid receptors: from genes to mice. (2000) (24)
A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice (2013) (24)
μ‐Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche (2014) (24)
Opioids in Pain Control: Opioid Receptors: Gene Structure and Function (1998) (23)
Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice (2017) (22)
Molecular Aspect of Opioid Receptors (1997) (22)
Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake. (2018) (21)
Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence (2011) (21)
BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone (2016) (21)
Effects of delta opioid receptors activation on a response inhibition task in rats (2011) (21)
Sequential and opposing alterations of 5-HT1A receptor function during withdrawal from chronic morphine (2011) (21)
Circadian-Dependent Learning and Memory Enhancement in Nociceptin Receptor-Deficient Mice with a Novel KUROBOX Apparatus Using Stress-Free Positive Cue Task (2007) (20)
In vitro pharmacological profile of peptide III-BTD: a novel ligand for nociceptin/orphanin FQ and opioid receptors. (2000) (19)
Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening. (2003) (19)
Focusing on the Opioid System for Addiction Biomarker Discovery. (2018) (19)
RSK2 signaling in brain habenula contributes to place aversion learning. (2011) (19)
Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP‐eGFP knock‐in mice (2018) (19)
Developmental and adult expression patterns of the G‐protein‐coupled receptor GPR88 in the rat: Establishment of a dual nuclear–cytoplasmic localization (2016) (18)
Drug discovery: Designing the ideal opioid (2016) (18)
Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus (2020) (18)
μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors (2020) (18)
Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine. (2004) (17)
Two faces for an opioid peptide—and more receptors for pain research (2002) (17)
Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain (2018) (17)
Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease (2019) (16)
Aryldiazonium salts as photo-affinity labelling reagents for proteins (1981) (16)
Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction (2016) (16)
Murine inter-strain polymorphisms alter gene targeting frequencies at the mu opioid receptor locus in embryonic stem cells (2001) (16)
Erratum: Resistance to diet-induced obesity in μ-opioid receptor-deficient mice: Evidence for a "thrifty gene" (Diabetes (February 2005) 54, (3510-3516)) (2006) (16)
Activity of mu‐ and delta‐opioid agonists in vas deferens from mice deficient in MOR gene (2001) (15)
Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently. (2002) (15)
Delta Opioid Receptors Regulate Temporoammonic-Activated Feedforward Inhibition to the Mouse CA1 Hippocampus (2013) (15)
In vivo neuronal co-expression of mu and delta opioid receptors uncovers new therapeutic perspectives. (2014) (15)
Activation of Nociceptin/Orphanin FQ Peptide Receptors Disrupts Visual but Not Auditory Sensorimotor Gating in BALB/cByJ Mice: Comparison to Dopamine Receptor Agonists (2012) (15)
Functional significance of cysteine residues in the delta opioid receptor studied by site-directed mutagenesis. (1998) (15)
Influence of Endogenous Opioid Systems on T Lymphocytes as Assessed by the Knockout of Mu, Delta and Kappa Opioid Receptors (2011) (14)
Knockout mouse models in pain research. (2004) (14)
Opioid effect on breathing frequency and thermogenesis in mice lacking exon 2 of the mu-opioid receptor gene. (2001) (14)
Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization (2014) (14)
GPR88 in A2A receptor‐expressing neurons modulates locomotor response to dopamine agonists but not sensorimotor gating (2017) (13)
Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration. (2004) (13)
No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse. (2004) (13)
Photosuicide inhibition — a step towards specific photoaffinity labelling (1982) (13)
Quantitative autoradiography of dopamine receptors in the brains of μ-opioid receptor knockout mice (2004) (12)
κ‐opioid receptors are not necessary for the antidepressant treatment of neuropathic pain (2015) (12)
The endogenous opioid dynorphin is required for normal bone homeostasis in mice (2012) (12)
micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. (2007) (11)
TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice (2019) (11)
GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior (2019) (11)
[35S]GTPγS binding: A tool to evaluate functional activity of a cloned opioid receptor transiently expressed in COS cells (1996) (11)
Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: A δ-opioid tone inhibits FADD (2007) (11)
Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve‐injured mice (2020) (11)
Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia (2020) (10)
Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies. (2021) (10)
PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research (2015) (10)
Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals (2020) (10)
Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice. (2019) (9)
NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice (2020) (9)
Medications between psychiatric and addictive disorders (2016) (9)
Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping (2018) (9)
The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs (2020) (9)
Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP‐, DOP‐, and KOP‐opioid receptor knockout mice of three different genetic backgrounds (2010) (8)
The nociceptin orphanin FQ peptide receptor agonist, Ro64-6198, impairs recognition memory formation through interaction with glutamatergic but not cholinergic receptor antagonists (2012) (8)
Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains (2004) (8)
Recent Findings on the Mechanism of Action of Morphine (1998) (8)
Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (8)
New automated procedure to assess context recognition memory in mice (2014) (8)
Knockout subtraction autoradiography: a novel ex vivo method to detect heteromers finds sparse KOP receptor/DOP receptor heterodimerization in the brain. (2014) (8)
Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains (2015) (7)
K-Opioid receptor in humans : cDNA and genomic cloning , chromosomal assignment , functional expression , pharmacology , and expression pattern in the central nervous system (2005) (7)
Knock‐in mice reveal nonsense‐mediated mRNA decay in the brain (2007) (7)
Respiratory function in adult mice lacking the mu-opioid receptor: role of delta-receptors. (2001) (7)
Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine (2021) (6)
Expression of opioid receptors mRNAs in immune cells (1994) (6)
Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists. (2020) (6)
Molecular Mechanisms of Opioid Dependence by Using Knockout Mice (2003) (6)
Structure—Function Relationships in G Protein-Coupled Receptors (2005) (6)
Translational Structural and Functional Signatures of Chronic Alcohol Effects in Mice (2022) (6)
Chronic generalized pain disrupts whole brain functional connectivity in mice (2021) (5)
G-protein coupling of δ-opioid receptors in brains of μ-opioid receptor knockout mice (2003) (5)
Ackr3-Venus knock-in mouse lights up brain vasculature (2021) (5)
m-Opioid Receptor Knockout Mice Do Not Self-Administer Alcohol 1 , 2 (2000) (4)
Evaluation of cre recombinase delivery in mammalian cells using baculovirus infection. (2013) (4)
Habenular Neurons Expressing Mu Opioid Receptors Promote Negative Affect in a Projection-Specific Manner (2022) (3)
In Vitro and In Vivo Mutagenesis: Insights into Delta Receptor Structure and Function (2003) (3)
Characterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice (2017) (3)
Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors (2022) (3)
Opioid Peptides and Receptors (2009) (3)
Preface (2008) (2)
Mapping the living mouse brain neural architecture: strain-specific patterns of brain structural and functional connectivity (2019) (2)
32P Labeled Opioid Peptides with High Affinity for the δ-Opioid Receptor (1993) (2)
Genetic Analysis of the Endogenous Opioid System (2004) (2)
Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice (2018) (2)
The Control of Reward Seeking (2018) (2)
Opioid receptors in GtoPdb v.2021.3 (2021) (2)
The GPR88 agonist RTI‐13951‐33 reduces alcohol drinking and seeking in mice (2022) (2)
Effect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Oprm1-Cre Knock-in Rats (2022) (2)
G-protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice. (2003) (2)
Knockdown of Hypocretin/Orexin Attenuates Extended-Access Cocaine Self-Administration in Rats (2017) (1)
The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder (2022) (1)
Molecular characterization of the human δ-opioid receptor (1994) (1)
Neurons expressing mu opioid receptors of the habenula promote negative affect in a projection-specific manner (2021) (1)
Opioid peptide signal in the brain makes mice hungrier for reward (2021) (1)
Opioides: Mecanismos básicos (2006) (1)
Animal Models of Addiction (2013) (1)
Differential Effects of Morphine on a Dispersed Respiratory Network to Induce Respiratory Depression in Awake Mice (2019) (1)
The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula (2022) (1)
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes analgesia (2011) (1)
Tracking in Molecular Bioimaging (2006) (0)
966 Localization and Function of Fluorescently-Tagged Delta Opioid Receptor (DOR) Expressed in Enteric Neurons of Knockin Mice (2010) (0)
S.6.4 - MU OPIOID RECEPTOR MODULATION OF STRIATAL GABAERGIC SYSTEM: CONSEQUENCES FOR STRIATAL FUNCTION AND PSYCHIATRIC DISORDERS (2013) (0)
P.1.26 Conditional knockout of mu opioid receptors (2009) (0)
Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice (2022) (0)
Cues predicting drug or food reward restore morphine-induced place conditioning in mice lacking delta opioid receptors (2012) (0)
This Week in The Journal Dopamine Transporter Is Rarely Endocytosed in Striatum (2015) (0)
The Opioid System : A Short History (2008) (0)
Zn2+ inhibits spatial memory and hippocampal place cell representation through high-affinity binding to the NMDA receptor GluN2A subunit (2022) (0)
P.6.d.022 Behavioural responses induced by nicotine in delta-opioid receptor knockout mice (2006) (0)
PHOTOSUICIDE INHIBITION OF ACETYLCHOLINESTERASE (1984) (0)
The 6opioid receptor: Isolation of a cDNA by expression cloning (0)
32P-labeled opioid peptides with high affinity for the delta-opioid receptor. (1993) (0)
PL.06.01 Opioid systems: probing molecular processes of brain function (2012) (0)
Targeting Opioid Receptors for Innovative Antidepressant Therapies: Rediscovering the Opioid Cure (2016) (0)
MONITORING G PROTEIN-COUPLED RECEPTORS DYNAMICS IN VIVO USING KNOCK-IN MICE EXPRESSING FLUORESCENT d-OPIOID RECEPTORS (2007) (0)
G.12 - CONTRIBUTION OF MU OPIOID RECEPTOR EXPRESSED IN GABAERGIC FOREBRAIN NEURONS TO ADDICTION: A CONDITIONAL KNOCKOUT APPROACH (2013) (0)
Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol (2022) (0)
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research (2018) (0)
Mu‐opioid receptors are involved in the tolerance to nicotine antinociception (2006) (0)
New automated procedure to assess context recognition memory in mice (2014) (0)
cotransmitter dynorphin in ventral tegmental area Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its (2015) (0)
Induction of (cid:1) Opioid Receptor Function by Up-Regulation of Membrane Receptors in Mouse Primary Afferent Neurons (2005) (0)
Ackr3-Venus knock-in mouse lights up brain vasculature (2021) (0)
Genetic deletion of mu opioid receptors from Kölliker‐Fuse neurons reduces morphine‐induced respiratory depression (2017) (0)
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing (2017) (0)
Monitoring Signalling and Trafficking of Neurotensin Type 1 Receptor in Animal Model using Fluorescent‐based Methods (2019) (0)
Opioid receptors: drivers to addiction? (2018) (0)
SHORT COMMUNICATION The rewarding properties of MDMA are preserved in mice lacking l-opioid receptors (2004) (0)
Localisation of the Delta Opioid Receptor (DOR) and Identification of Enkephalin-Expressing Cells in the Mouse Retina (2011) (0)
Live molecular recognition: visualizing opioid receptors trafficking in vivo (2009) (0)
A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks (2014) (0)
Distinct and sex-specific expression of mu opioid receptors in anterior cingulate and somatosensory S1 cortical areas (2022) (0)
Advances in the characterization of negative affect caused by acute and protracted opioid withdrawal using animal models (2023) (0)
The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex. (2021) (0)
Knockout Subtraction Autoradiography : a novel ex vivo method to detect heteromers finds sparse KOPr / DOPr heterodimerization in the brain (2014) (0)
Molecular characterization of opioid receptors (1994) (0)
human kappa opioid receptor, nucleic acid and uses. (1995) (0)
Channel Activation IR K Through Oscillations and Prolactin Release 2+ Spontaneous Ca (2015) (0)
Corrigendum (2017) (0)
S.01.02 Drug discovery: Designing the ideal opioid (2019) (0)
CONTROL OF Abeta LOW-THRESHOLD MECHANORECEPTOR INPUTS TO SPINAL CORD NEURONS BY DELTA OPIOID RECEPTORS (2012) (0)
Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor. (2022) (0)
On the Digital Trail of Mobile Cells ( Understanding (2006) (0)
TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice (2019) (0)
A New Approach to Visualize Endogenously Expressed G Protein-Coupled Receptors in Tissues and Living Cells (2011) (0)
Neuropeptide Y is Critical to the Central Effects of the Endogenous Opioid System on Bone (2010) (0)
SHORT COMMUNICATION Neuropathic pain is enhanced in d-opioid receptor knockout mice (2006) (0)
A novel anxiogenic role for the delta opioid receptor expressed in forebrain GABAergic neurons (2017) (0)
Figure 1 : Examples of biologically relevant components : Amygdala ( Bi ) and CPu ( L & R ) 823 Mapping the Resting State Functional Connectivity in the GPR 88 KO mouse brain (2013) (0)
Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. (2023) (0)
An Anti-Opioid System, Courtesy of a Worm Model. (2019) (0)
Modeling of STRUCTURE OF HUMAN DELTA OPIOID RECEPTOR (2003) (0)
Receiver human kappa opioid, nucleic acids and uses (1994) (0)
Nonhuman transgenic animal in which expression of at least genes coding for receptors to opiates is amended (1996) (0)
brain signal that makes mice hungrier for reward (2021) (0)
Author response: The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs (2020) (0)
ENKEPHALIN-INDUCED DESENSITIZATION OF ADENYLATE CYCLASE IN RECOMBINANT CV CELLS EXPRESSING A MOUSE δ-OPIOID RECEPTOR (1995) (0)
Mouse Delta Opioid Receptors are Located on Presynaptic Afferents to Hippocampal Pyramidal Cells (2012) (0)
B60 INVOLVEMENT OF OPIOID RECEPTORS IN THE TOLERANCE TO NICOTINE ANTINOCICEPTIVE EFFECTS (2005) (0)
Human kappa opioid receptor, nucleic acids and their uses (1995) (0)

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