Brooke T. Mossman
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Brooke T. Mossman's Degrees
- PhD Biomedical Engineering Stanford University
- Masters Biomedical Engineering Stanford University
Why Is Brooke T. Mossman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Brooke T. Mossman is an American pathologist, a University Distinguished Professor emeritus at the University of Vermont. She is known for her research on diseases caused by asbestos.
Brooke T. Mossman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) (2447)
- Mechanisms in the pathogenesis of asbestosis and silicosis. (1998) (909)
- Asbestos: scientific developments and implications for public policy. (1990) (724)
- Redox-based regulation of signal transduction: principles, pitfalls, and promises. (2008) (718)
- Cell and tissue responses to oxidative damage. (1993) (523)
- Differential regulation of antioxidant enzymes in response to oxidants. (1991) (411)
- Asbestos-related diseases. (1989) (343)
- Diseases caused by silica: mechanisms of injury and disease development. (2002) (324)
- Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases. (2003) (276)
- Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro. (2000) (269)
- The pathogenesis of asbestos-associated diseases. (1982) (262)
- TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis (2006) (259)
- Generation of superoxide (O2-.) from alveolar macrophages exposed to asbestiform and nonfibrous particles. (1987) (245)
- Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor. (1996) (236)
- Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers. (1996) (214)
- Persistent induction of c-fos and c-jun expression by asbestos. (1993) (213)
- Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B (1999) (200)
- Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos (2011) (196)
- The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases (2015) (191)
- Diseases caused by asbestos: mechanisms of injury and disease development. (2002) (188)
- Assessing nanotoxicity in cells in vitro. (2010) (186)
- Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells. (1995) (182)
- Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. (2002) (181)
- Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. (2010) (165)
- Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. (1990) (164)
- Glutathione redox system in oxidative lung injury. (1999) (162)
- Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica. (1992) (161)
- Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma (2000) (160)
- Oxidants and signaling by mitogen-activated protein kinases in lung epithelium. (2006) (159)
- Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth (2005) (156)
- Regulation of antioxidant enzymes in lung after oxidant injury. (1994) (153)
- Silica induces NLRP3 inflammasome activation in human lung epithelial cells (2013) (150)
- Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2. (1997) (147)
- Alteration of superoxide dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants. (1986) (146)
- Role and regulation of activator protein-1 in toxicant-induced responses of the lung. (2002) (143)
- Cellular and molecular mechanisms of asbestos‐induced fibrosis (1999) (137)
- Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells. (1995) (133)
- ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. (2005) (132)
- Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases (2007) (130)
- Down-regulation of Manganese-Superoxide Dismutase through Phosphorylation of FOXO3a by Akt in Explanted Vascular Smooth Muscle Cells from Old Rats* (2006) (123)
- Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease. (1989) (122)
- Asbestos: mechanisms of toxicity and carcinogenicity in the respiratory tract. (1983) (121)
- Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers. (1998) (117)
- Prevention of asbestos-induced cell death in rat lung fibroblasts and alveolar macrophages by scavengers of active oxygen species. (1987) (111)
- Mesothelial cell transformation requires increased AP-1 binding activity and ERK-dependent Fra-1 expression. (2002) (111)
- Transcriptional activation of the proto-oncogene c-jun by asbestos and H2O2 is directly related to increased proliferation and transformation of tracheal epithelial cells. (1995) (110)
- Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos. (1996) (108)
- Myeloperoxidase Deficiency Attenuates Lipopolysaccharide-Induced Acute Lung Inflammation and Subsequent Cytokine and Chemokine Production1 (2009) (108)
- Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells. (1997) (107)
- TNFα and increased chemokine expression in rat lung after particle exposure (1995) (106)
- Induction of c-fos and c-jun proto-oncogenes in target cells of the lung and pleura by carcinogenic fibers. (1994) (105)
- Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice. (2002) (104)
- Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells (2013) (102)
- Patterns of 8-hydroxydeoxyguanosine formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos. (1997) (101)
- Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells. (2001) (98)
- Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma. (2003) (97)
- Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis. (1999) (97)
- New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas. (2013) (97)
- Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells (1984) (94)
- Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. (2006) (93)
- Differential induction of c- fos, c- jun, and apoptosis in lung epithelial cells exposed to ROS or RNS. (1997) (91)
- Interaction of crocidolite asbestos with hamster respiratory mucosa in organ culture. (1977) (91)
- Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos (2004) (90)
- Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress. (2001) (90)
- Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants. (1999) (88)
- Asbestos-induced epithelial changes in organ cultures of hamster trachea: inhibition by retinyl methyl ether. (1980) (88)
- Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models. (1998) (86)
- Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos. (1997) (86)
- Cell signaling and transcription factor activation by asbestos in lung injury and disease. (2003) (85)
- Activation of cell membrane enzymes in the stimulation of cell division. (1972) (85)
- Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. (1994) (85)
- Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis. (2003) (84)
- Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells. (1998) (84)
- Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model (2010) (83)
- Silica, silicosis, and lung cancer: a response to a recent working group report. (2000) (81)
- Oxidant stress responses in human pleural mesothelial cells exposed to asbestos. (1994) (77)
- Myeloperoxidase modulates lung epithelial responses to pro-inflammatory agents (2008) (75)
- Induction of squamous metaplasia in organ cultures of hamster trachea by naturally occurring and synthetic fibers. (1983) (75)
- Cellular and molecular parameters of mesothelioma (2006) (74)
- Dose-responsive increases in pulmonary fibrosis after inhalation of asbestos. (1994) (74)
- A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression. (2002) (73)
- Increased phosphorylated extracellular signal-regulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice. (2000) (73)
- Increased manganese superoxide dismutase protein in type II epithelial cells of rat lungs after inhalation of crocidolite asbestos or cristobalite silica. (1992) (71)
- In vitro approaches for determining mechanisms of toxicity and carcinogenicity by asbestos in the gastrointestinal and respiratory tracts. (1983) (69)
- Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos. (1995) (69)
- Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis. (2005) (68)
- Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos. (1996) (68)
- Mechanisms of asbestos carcinogenesis. (1981) (68)
- HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway. (2008) (68)
- Role of asbestos and active oxygen species in activation and expression of ornithine decarboxylase in hamster tracheal epithelial cells. (1991) (68)
- Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma (2016) (65)
- Unique uptake of acid-prepared mesoporous spheres by lung epithelial and mesothelioma cells. (2007) (64)
- Oxygen radicals and asbestos-mediated disease. (1994) (64)
- Cell signaling pathways elicited by asbestos. (1997) (64)
- Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells (2012) (62)
- Ambient particulate matter causes activation of the c-jun kinase/stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells. (1998) (62)
- Asbestos-Induced Apoptosis Is Protein Kinase Cδ-Dependent (2003) (60)
- Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity. (2009) (59)
- Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin (2010) (58)
- Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice. (2007) (58)
- Effects of crocidolite and chrysotile asbestos on cellular uptake and metabolism of benzo(a)pyrene in hamster tracheal epithelial cells. (1983) (57)
- Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters (2006) (56)
- GRP78, HSP72/73, and cJun stress protein levels in lung epithelial cells exposed to asbestos, cadmium, or H2O2. (1998) (55)
- Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice. (2005) (55)
- Mechanisms of induction of ornithine decarboxylase activity in tracheal epithelial cells by asbestiform minerals. (1988) (55)
- Influence of asbestos on the uptake of benzo(a)pyrene and DNA alkylation in hamster tracheal epithelial cells. (1983) (54)
- Assessment of the pathogenic potential of asbestiform vs. nonasbestiform particulates (cleavage fragments) in in vitro (cell or organ culture) models and bioassays. (2008) (54)
- A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. (2010) (53)
- Use of hamster tracheal organ cultures for assessing the cocarcinogenic effects of inorganic particulates on the respiratory epithelium. (1979) (51)
- Peroxiredoxin 3 Is a Redox-Dependent Target of Thiostrepton in Malignant Mesothelioma Cells (2012) (51)
- Pleural Cell Biology in Health and Disease (1992) (50)
- Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. (2009) (50)
- Enhanced lipid peroxidation in lung lavage of rats after inhalation of asbestos. (1991) (49)
- Airway Epithelial NF-κB Activation Modulates Asbestos-Induced Inflammation and Mucin Production In Vivo1 (2007) (49)
- Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis. (2011) (48)
- TNF alpha and increased chemokine expression in rat lung after particle exposure. (1995) (46)
- Transfection of a manganese-containing superoxide dismutase gene into hamster tracheal epithelial cells ameliorates asbestos-mediated cytotoxicity. (1996) (46)
- Effects of Mineral Dusts on Cells (1989) (46)
- Crocidolite activates NF-kappa B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants. (1998) (46)
- Implication of active oxygen species as second messengers of asbestos toxicity. (1987) (46)
- Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs) (2013) (45)
- Persistent localization of activated extracellular signal-regulated kinases (ERK1/2) is epithelial cell-specific in an inhalation model of asbestosis. (2003) (45)
- Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells. (1997) (45)
- Human mesothelioma cells exhibit tumor cell–specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase (2005) (44)
- Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells. (2002) (44)
- Asbestos and cigarette smoke cause increased DNA strand breaks and necrosis in bronchiolar epithelial cells in vivo. (2000) (44)
- Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos. (1996) (43)
- In vitro and in vivo activation of extracellular signal-regulated kinases by coal dusts and quartz silica. (2002) (43)
- Mechanisms of asbestos carcinogenesis and toxicity: the amphibole hypothesis revisited. (1993) (43)
- Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells (2008) (43)
- Introduction to serial reviews on the role of reactive oxygen and nitrogen species (ROS/RNS) in lung injury and diseases. (2003) (43)
- Detection of lipid peroxidation in lung and in bronchoalveolar lavage cells and fluid. (1990) (42)
- In vitro assays to predict the pathogenicity of mineral fibers. (1990) (42)
- ERK2 is essential for the growth of human epithelioid malignant mesotheliomas (2011) (41)
- Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer. (2010) (41)
- Mitochondrial-derived oxidants and quartz activation of chemokine gene expression. (2001) (40)
- Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos. (2002) (40)
- Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation (2014) (40)
- Patterns of c-fos and c-jun proto-oncogene expression, apoptosis, and proliferation in rat pleural mesothelial cells exposed to erionite or asbestos fibers. (1998) (40)
- Comparative effects of fibrous and nonfibrous minerals on cells and liposomes. (1982) (40)
- Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2. (1997) (40)
- Extracellular Signal–Regulated Kinase 5: A Potential Therapeutic Target for Malignant Mesotheliomas (2013) (39)
- Isolation and spontaneous transformation of cloned lines of hamster tracheal epithelial cells. (1980) (39)
- Free radical mechanisms in chemical pathogenesis. Summary of the symposium presented at the 1988 annual meeting of the Society of Toxicology. (1988) (39)
- Squamous metaplasia of the respiratory tract. Possible pathogenic role in asbestos-associated bronchogenic carcinoma. (1983) (38)
- Hydrolysis of inositol phospholipids precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells. (1990) (38)
- The Duration of Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Signaling during Cell Cycle Reentry Distinguishes Proliferation from Apoptosis in Response to Asbestos (2004) (37)
- Role of mitogen-activated protein kinases (MAPK) in cell injury and proliferation by environmental particulates (2002) (37)
- Mineralogical features associated with cytotoxic and proliferative effects of fibrous talc and asbestos on rodent tracheal epithelial and pleural mesothelial cells. (1997) (36)
- MECHANISMS OF ACTION OF POORLY SOLUBLE PARTICULATES IN OVERLOAD-RELATED LUNG PATHOLOGY (2000) (36)
- Identification of Neoplastic Versus Normal Cells in Human Cervical Cell Culture (1974) (35)
- Transcriptional up‐regulation of MMPs 12 and 13 by asbestos occurs via a PKCδ‐dependent pathway in murine lung (2006) (35)
- SV40, growth factors, and mesothelioma: another piece of the puzzle. (2002) (35)
- Transcriptional up‐regulation of MMPs 12 and 13 by asbestos occurs via a PKCδ‐dependent pathway in murine lung (2006) (35)
- Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS. (1997) (34)
- Cell imaging techniques : methods and protocols (2006) (33)
- Asbestos-induced apoptosis is protein kinase C delta-dependent. (2003) (33)
- Chromium (VI) inhibits heme oxygenase‐1 expression in vivo and in arsenic‐exposed human airway epithelial cells (2006) (33)
- Expression and activity of urokinase and its receptor in endothelial and pulmonary epithelial cells exposed to asbestos. (1998) (33)
- Long-Term Maintenance of Differentiated Respiratory Epithelium in Organ Culture I. Medium Composition 1 (1975) (33)
- Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy (2011) (32)
- Activation of protein kinase C by crocidolite asbestos in hamster tracheal epithelial cells. (1991) (32)
- Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2. (2007) (32)
- Antitumor effects of TRAIL-expressing mesenchymal stromal cells in a mouse xenograft model of human mesothelioma (2014) (31)
- Utilization of Gene Profiling and Proteomics to Determine Mineral Pathogenicity in a Human Mesothelial Cell Line (LP9/TERT-1) (2010) (31)
- Oxidant-mediated cAMP response element binding protein activation: calcium regulation and role in apoptosis of lung epithelial cells. (2006) (31)
- In vitro studies on the biologic effects of fibers: correlation with in vivo bioassays. (1990) (30)
- Formation and removal of benzo(a)pyrene adducts of DNA in hamster tracheal epithelial cells. (1981) (29)
- Gd-labeled microparticles in MRI: in vivo imaging of microparticles after intraperitoneal injection. (2010) (29)
- The γ-Glutamylcysteine Synthetase and Glutathione Regulate Asbestos-induced Expression of Activator Protein-1 Family Members and Activity (2004) (29)
- A new method for quantifiable and controlled dosage of particulate matter for in vitro studies: the electrostatic particulate dosage and exposure system (EPDExS). (2008) (29)
- Comparative studies on the cytotoxicity of amphibole and serpentine asbestos. (1980) (28)
- Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression (2006) (28)
- Approaches to prevention of asbestos-induced lung disease using polyethylene glycol (PEG)-conjugated catalase. (1986) (28)
- Cocarcinogenic and tumor promoting properties of asbestos and other minerals in tracheobronchial epithelium. (1985) (28)
- Cellular and molecular mechanisms of asbestosis. (1986) (27)
- A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos. (2009) (27)
- Pathogenetic mechanisms of asbestos and other mineral fibres. (1990) (26)
- Modulation of cell injury and survival by high glucose and advancing age. (2001) (26)
- Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells (2010) (25)
- Age‐related differences in MAP kinase activity in VSMC in response to glucose or TNF‐α (2003) (25)
- Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas (2007) (25)
- Comparative cocarcinogenic effects of crocidolite asbestos, hematite, kaolin and carbon in implanted tracheal organ cultures. (1982) (24)
- SV40 detection in human tumor specimens. (2005) (24)
- Interaction of carbon particles with tracheal epithelium in organ culture. (1978) (24)
- NHLBI workshop summary. Environmental lung diseases. Relationship between acute inflammatory responses to air pollutants and chronic lung disease. (1992) (23)
- Laser-based microscopic approaches: application to cell signaling in environmental lung disease. (2001) (23)
- Carcinogenesis and related cell and tissue responses to asbestos: a review. (1994) (22)
- Asbestos and benzo[a]pyrene act synergistically to induce squamous metaplasia and incorporation of [3H]thymidine in hamster tracheal epithelium. (1984) (21)
- Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. (2015) (20)
- Carcinogenic potential of asbestos and nonasbestos fibers (1988) (20)
- Health effects of Mount St. Helens volcanic dust. (1983) (19)
- Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplant. (2008) (19)
- Paclitaxel and vinorelbine cause synergistic increases in apoptosis but not in microtubular disruption in human lung adenocarcinoma cells (A-549) (2004) (19)
- Regulation of differentiation and keratin protein expression by vitamin A in primary cultures of hamster tracheal epithelial cells (1990) (18)
- 87 TNF-α inhibits asbestos induced cytotoxicity via a NF-kB dependent pathway: A possible mechanism for asbestos-induced oncogenesis (2006) (18)
- Increases in endogenous antioxidant enzymes during asbestos inhalation in rats. (1990) (18)
- Use of transgenic luciferase reporter mice to determine activation of transcription factors and gene expression by fibrogenic particles. (2001) (18)
- Asbestos-related cancer and the amphibole hypothesis. The hypothesis is still supported by scientists and scientific data. (1997) (17)
- Squamous metaplasia of the tracheal epithelium in organ culture. I. Effects of hydrocortisone and beta-retinyl acetate. (1976) (17)
- Mechanisms of fibre-induced superoxide release from alveolar macrophages and induction of superoxide dismutase in the lungs of rats inhaling crocidolite. (1989) (17)
- Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos. (2008) (17)
- Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells. (2016) (16)
- Simultaneous triple fluorescence detection of mRNA localization, nuclear DNA, and apoptosis in cultured cells using confocal scanning laser microscopy (1997) (16)
- Increased neutrophil adherence to endothelial cells exposed to asbestos. (1996) (16)
- Mechanistic in vitro studies: What they have told us about carcinogenic properties of elongated mineral particles (EMPs). (2018) (16)
- Measurement of oxidant-induced signal transduction proteins using cell imaging. (1999) (16)
- Characterisation of airborne particulate matter and related mechanisms of toxicity: an experimental approach (2006) (16)
- Mechanisms of Toxic Injury by Asbestos Fibers: Role of Oxygen-Free Radicals (1985) (16)
- Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. (1998) (16)
- Interaction of asbestos with metaplastic squamous epithelium developing in organ cultures of hamster trachea. (1983) (15)
- Cellular and molecular mechanisms of disease (1993) (15)
- Towards a general model for predicting the toxicity and pathogenicity of mineral fibres (2017) (15)
- Sensitivity of hamster tracheal epithelial cells to asbestiform minerals modulated by serum and by transforming growth factor beta 1. (1989) (14)
- Dose-Response Relationships in Expression of Biomarkers of Cell Proliferation in In Vitro Assays and Inhalation Experiments (2004) (14)
- Gene profiling and kinase screening in asbestos-exposed epithelial cells and lungs. (2003) (14)
- Effects of Aramid, a high strength synthetic fiber, on respiratory cells in vitro. (1994) (14)
- Mechanisms of asbestos-induced squamous metaplasia in tracheobronchial epithelial cells. (1989) (13)
- Brief inhalation of asbestos compromises superoxide production in cells from bronchoalveolar lavage. (1990) (13)
- An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury. (2011) (13)
- Glycoprotein synthesis by an established cell line from hamster tracheal epithelium. (1980) (13)
- Possible Mechanisms of Crystalline Silica-Induced Lung Disease (1995) (12)
- Inhaled Asbestos Exacerbates Atherosclerosis in Apolipoprotein E–Deficient Mice via CD4+ T Cells (2008) (12)
- Merging the geological and biological sciences; an integrated approach to the study of mineral-induced pulmonary diseases (1993) (12)
- Development and Characterization of a Rapid-Onset Rodent Inhalation Model of Asbestosis for Disease Prevention 1 (1991) (12)
- Therapeutic and diabetogenic potential of two newly synthesized nitrosoureido sugars. (1985) (12)
- Inhibition of mesothelioma cancer stem‐like cells with adenovirus‐mediated NK4 gene therapy (2015) (12)
- Strategies for evaluation of signaling pathways and transcription factors altered in aging. (2000) (12)
- Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos (2000) (12)
- Chrysotile and Crocidolite Asbestos Pulmonary Fibre Concentrations and Dimensions after Inhalation and Clearance in Fischer 344 Rats (1988) (12)
- Age-related differences in MAP kinase activity in VSMC in response to glucose or TNF-alpha. (2003) (11)
- Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas. (2014) (11)
- Squamous Metaplasia of the Tracheal Epithelium in Organ Culture. II. Nutritional Influences 1 (1978) (11)
- Signal transduction by oxidants: look who's talking. (2000) (11)
- Mechanisms of Hypersecretion in Rodent Tracheal Explants after Exposure to Chrysotile Asbestos (1982) (11)
- NHLBI workshop summaries. Pleural cell biology in health and disease. (1992) (10)
- Interaction of Mount St. Helens' volcanic ash with cells of the respiratory epithelium. (1984) (10)
- Petrodiesel and waste grease biodiesel (B20) emission particles at a rural recycling center: characterization and effects on lung epithelial cells and macrophages (2014) (10)
- Topical Application of Polycyclic Hydrocarbons to Differentiated Respiratory Epithelium in Long-Term Organ Cultures (1974) (10)
- Comparative interactions of streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr) (1986) (10)
- Advances in molecular genetics, transgenic models, and gene therapy for the study of pulmonary diseases. (1995) (9)
- Asbestos-associated cancers: Clinical spectrum and pathogenic mechanisms (2002) (9)
- Autoradiography for determination of DNA synthesis in hamster bladder epithelium (1977) (9)
- Chlorozocin: A Diabetogenic Analogue of Streptozocin with Dissimilar Mechanisms of Action on Pancreatic Beta Cells (1985) (9)
- A possible mechanism of chrysotile asbestos toxicity. (1987) (8)
- Health effects of mineral dusts, Volume 28: Proceedings (1993) (8)
- Induction of neoplasms in hamster tracheal grafts with 3-methylcholanthrene-coated Lycra fibers. (1978) (8)
- Use of pancreatic beta cells in culture to identify diabetogenicN-nitroso compounds (2007) (8)
- Lung Cancer: Mechanisms of Carcinogenesis by Asbestos (2020) (7)
- DOWN REGULATION OF MnSOD THROUGH PHOSPHORYLATION OF FOXO 3 a BY AKT IN EXPLANTED VSMC FROM OLD RATS * (2006) (7)
- Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts (2013) (7)
- Chapter 9 Cell Signaling by Oxidants: Pathways Leading to Activation of Mitogen-activated Protein Kinases (MAPK) and Activator Protein-1 (AP-1) (2008) (7)
- Molecular Responses to Asbestos: Induction of Cell Proliferation and Apoptosis Through Modulation of Redox-Dependent Cell Signaling Pathways (2008) (6)
- Crystalline silica alters Sulfatase‐1 expression in rat lungs which influences hyper‐proliferative and fibrogenic effects in human lung epithelial cells (2018) (6)
- Repetitive dissociation from crocidolite asbestos acts as persistent signal for epidermal growth factor receptor. (2013) (6)
- Review Article (1999) (6)
- Investigations into the Mechanisms of Asbestos Toxicity (1985) (6)
- Alterations in keratin expression in hamster tracheal epithelial cells exposed to benzo[a]pyrene. (1991) (6)
- Modern criteria to determine the etiology of human carcinogens. (2004) (6)
- In vivo cell biology. (1994) (6)
- Antioxidant Defense Mechanisms in Asbestos-Induced Lung Disease (1990) (5)
- Cell Signaling and Epigenetic Mechanisms in Mesothelioma (2017) (5)
- Modulation of the interaction of benzo[a]pyrene with a hamster tracheal epithelial cell line. (1982) (5)
- Pathogenesis and Mechanisms of Asbestosis and Silicosis (2014) (5)
- A Multifunctional Mesothelin Antibody-tagged Microparticle Targets Human Mesotheliomas (2012) (5)
- In reply: asbestos, carcinogenicity, and public policy. (1990) (5)
- Tumour Necrosis Factor (TNF): Evidence for the Role of TNF in Increased Expression of Manganese Superoxide Dismutase after Inhalation of Mineral Dusts (1994) (5)
- CONTEMPORARY ISSUES IN TOXICOLOGY Free Radical Mechanisms in Chemical Pathogenesis (2003) (5)
- Carcinoma induction by 3-methylcholanthrene in hamster tracheal tissue implanted in syngeneic animals. (1979) (4)
- CHAPTER 17. CELLULAR AND MOLECULAR MECHANISMS OF DISEASE (1993) (4)
- ASBESTOS-RELATED DISEASES. AUTHOR'S REPLY (1991) (4)
- Another Piece of the Puzzle (2002) (4)
- Highlight Commentary on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles". (2007) (4)
- Asbestos-Induced Mesothelioma (2005) (4)
- In vitro biological activity and mechanisms of lung and pleural cancers induced by mineral fibres (2017) (4)
- Multifluorescence labeling techniques and confocal laser scanning microscopy on lung tissue. (2006) (4)
- Asbestos and Fibrous Glass Induce Biosynthesis of Polyamines in Tracheobronchial Epithelial Cells In Vitro (1985) (3)
- Preface of the series (2006) (3)
- Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas (2017) (3)
- Asbestosis and Asbestos-Related Cancers: Role of Reactive Oxygen and Nitrogen Species (2004) (3)
- Effects of Asbestos on Specific Binding of Phorbol Ester Tumor Promoter and Protein Kinase C Activity in Hamster Tracheal Epithelial (HTE) Cells (1989) (3)
- Activation of Early Cellular Responses by Asbestos: Induction of c-FOS and c-JUN Protooncogene Expression in Rat Pleural Mesothelial Cells (1994) (3)
- Drinking-Water Criteria Document for Asbestos (final draft), March 1985 (1985) (3)
- Molecular Mechanism for the Induction of Mesothelioma by Asbestos (2011) (2)
- Analysis of asbestos-induced gene expression changes in bronchiolar epithelial cells using laser capture microdissection and quantitative reverse transcriptase-polymerase chain reaction. (2006) (2)
- and Activation of Extracellular Signal-Regulated Kinases by Coal Dusts and Quartz Silica (2002) (2)
- Asbestos induces nuclear factor cB (NF-cB) DNA-binding activity and NF-cB-dependent gene expression in tracheal epithelial cells (2016) (2)
- Induction of Gene Expression by Environmental Oxidants Associated with Inflammation, Fibrogenesis, and Carcinogenesis (1997) (2)
- In fl ammation-Related IL 1 b / IL 1 R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma (2016) (2)
- Asbestos-induced phosphorylation of epidermal growth (2011) (1)
- Extracellular signal regulated kinases (ERK1/2) play an important role in migration, invasion and chemoresistance of human mesotheliomas (2008) (1)
- The Role of Free Radicals in Asbestos- and Silica-Induced Fibrotic Lung Diseases (2001) (1)
- ASBESTOS-RELATED CANCER AND THE AMPHIBOLE HYPOTHESIS. AUTHORS' REPLY (1997) (1)
- Abstract 5461: Role of the NLRP3 inflammasome in the development and drug resistance of malignant mesothelioma (2012) (1)
- Asbestos Mediated Gene Expression in Rat Lung (1991) (1)
- Letter to the Editor: Fletcher NM, Harper AK, Memaj I, Fan R, Morris RT, Saed GM. Molecular Basis Supporting the Association of Talcum Powder Use with Increased Risk of Ovarian Cancer. Reprod Sci. 2019;26(12):1603–12. DOI: 10.1177/1933719119831773 (2020) (1)
- Physical Agents in Human Carcinogenesis (2002) (1)
- Organ culture of the hamster bladder epithelium (1977) (1)
- Alteration of cell membrane enzymes in the stimulation of cell division. Abstr. (1973) (1)
- Matrix metalloproteinases regulation by asbestos in murine lung:Role of protein kinase C delta (2006) (1)
- Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation (2014) (1)
- Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. (2006) (1)
- Environmental pathology: new directions and opportunities. (1999) (1)
- Cell-Signaling Pathways Elicited by Particulates (2006) (1)
- Asbestos and silica exposures reveal similar and divergent gene expression patterns and pathways related to fibrosis in human bronchial epithelial cells (2012) (1)
- Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts (2013) (1)
- RNA Interference Technology: Microarray analysis and RNA silencing to determine genes functionally important in mesothelioma (2005) (1)
- Health effects of mineral dusts : proceedings of a short course endorsed by the American College of Chest Physicians and The U. S. Geological Survey (1993) (1)
- Silica, Silicosis, and Lung Cancer (2001) (1)
- Abstract 347: Inhibition of ERK1/2 can sensitize human malignant mesothelioma cells and tumors to doxorubicin (2010) (0)
- Binding Activity and ERK-dependent Fra-1 Expression Mesothelial Cell Transformation Requires Increased AP-1 (2013) (0)
- Oxidant-mediated activation of ornithine decarboxylase (ODC) in tracheal epithelial cells (1990) (0)
- ALUNG October 21/4 (1999) (0)
- Expression of FOXM1 in LP9 mesothelial cells and MM cells lines. (2013) (0)
- Multiple signalling pathways and transcription factors lead to protooncogene induction by crocidolite asbestos in rat pleural mesothelial (RPM) cells (1996) (0)
- Advances in Brief Inhibition of Protein Kinase C Prevents Asbestos-induced c-fos and c-jun Proto Oncogene Expression in Mesothelial Cells 1 (2006) (0)
- Mechanisms of Asbestos-lnduced Squamous Metaplasia in Tracheobronchial (2016) (0)
- Advances in Brief A Mutant Epidermal Growth Factor Receptor Targeted to Lung Epithelium Inhibits Asbestos-induced Proliferation and Proto-Oncogene Expression 1 (2002) (0)
- Proto-Oncogene Expression in Mesothelial Cells jun and c-fos Inhibition of Protein Kinase C Prevents Asbestos-induced c-Updated Version (2006) (0)
- Targeted Delivery of Doxorubicin to Human Mesotheliomas Using Acid-Prepared Mesoporous Spheres Increases Expression of DNA Damage and Response GenesIn Vitroand Inhibits Tumor Growth in SCID Mice. (2009) (0)
- Sensitivity of Hamster Trachà © alEpithelial Cells to Asbestiform Minerals Modulated by Serum and by Transforming Growth Factor ßl (2006) (0)
- Mechanisms of asbestos carcinogenesis in the respiratory tract (1986) (0)
- Inflammation and Subsequent Cytokine and Lipopolysaccharide-Induced Acute Lung Myeloperoxidase Deficiency Attenuates (2013) (0)
- Response : Asbestos, Carcinogenicity, and Public Policy (1990) (0)
- 223 Nanoporous spheres for drug delivery in mesotheliomax (2006) (0)
- Advances in Brief Ambient Particulate Matter Causes Activation of the c-jun Kinase / Stress-activated Protein Kinase Cascade and DNA Synthesis in Lung Epithelial Cells 1 (2006) (0)
- Cyclic AMP response element binding protein (CREB) regulation by asbestos (2007) (0)
- OXIDANTS AND ANTIOXIDANTS | Oxidants (2006) (0)
- Malignant Mesothelioma: Cell Survival Pathways and Radiation Therapy (2015) (0)
- via Oxidative Stress , and S-Phase Alterations Are Mediated fra-1 Proto-Oncogene , Kinases , Protracted Expression of the Activator Protein-1-Terminal Amino 2 Silica-induced Activation of c-Jun-NH Updated (2001) (0)
- Lung after Inhalation of Chrysotile Asbestos (2007) (0)
- Explorer Mechanisms of action of inhaled fibers , particles and nanoparticles in lung and cardiovascular diseases (2017) (0)
- Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells (2013) (0)
- Silica-induced inflammasome activation in vitro and in rat lungs (2013) (0)
- Abstract 4315: Extracellular signal regulated kinase 5 inpathogenesis of malignant mesothelioma. (2013) (0)
- Epithelial and Pleural Mesothelial Cells (2007) (0)
- NHLBI ~orkshop~S~u~m~m (1994) (0)
- Effects of TRAIL-Expressing MSCs on Mesothelioma (2014) (0)
- T the Ups and Downs of Asbestos's Past (0)
- Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells (2012) (0)
- Profiles of antioxidant enzyme expression in rat lungs after inhalation of asbestos or silica (1990) (0)
- BIOLOGICAL ENDPOINTS TO ASSESS PULMONARY AND CARDIOPULMONARY DAMAGE (2005) (0)
- Summary and Synthesis of Part IV. Effects of Mineral Dusts on Cell Metabolism in Relation to Inflammation and Fibrogenesis (B) (1985) (0)
- Silica induces NLRP3 inflammasome activation in human lung epithelial cells (2013) (0)
- Summary and Synthesis of Part IV. Synthesis and Release of Mediators (A) (1985) (0)
- PL Cell Signaling and Gene Expression by Asbestos in Mesothelioma (2007) (0)
- Mechanisms and shapes of causal exposure-response functions for asbestos in mesotheliomas and lung cancers. (2023) (0)
- Asbestos: facts and fiction. (1994) (0)
- Mineralogical and geochemical aspects of mineral-induced disease (1996) (0)
- Abstract 842: The NALP3 inflammasome and IL-1â signaling link asbestos-induced inflammation with the development of malignant mesothelioma (2016) (0)
- Abstract LB-28: Regulation of FOXM1 by NADPH oxidases in malignant mesothelioma cells (2010) (0)
- Ambient particulate matter (PM2.5) induces multiple signalling pathways in rodent alveolar type II epithelial cells [Abstract] (1999) (0)
- 13 Cell signaling and transcription factor activation by asbestos (2006) (0)
- Targeting Redox Homeostasis in Malignant Mesothelioma (2011) (0)
- Induction of c-fos and c-jun Proto-oncogene Expression by Asbestos Is Ameliorated by A ^-Acetyl-L-Cysteine in Mesothelial Cells 1 (2006) (0)
- The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases (2015) (0)
- Oxygen free radicals in pulmonary fibrosis. Final report (1989) (0)
- 9-1-1997 Cell Signaling Pathways Elicited by Asbestos (2019) (0)
- Abstract 2646: Biodistribution of multifunctional microparticles (APMS) for targeted delivery of chemotherapeutic drugs (2010) (0)
- Abstract 2882: CREB inhibition attenuates MM tumor growth and drug resistance (2011) (0)
- Environmental Agents in Lung and Pleural Neoplasms (2008) (0)
- 1 ) dfnago The Rip-Out Rip-Off The Asbestos Racket : An Environmental Parable (2008) (0)
- 2 Asbestos-Induced Mesothelioma (0)
- Are Biodiesel (B20) Emissions Less Harmful than Petrodiesel (B0) (2011) (0)
- Hepatocyte Growth Factor mediates growth through the activation of ERK5 in mesothelioma cell lines (2006) (0)
- Asbestos warrants care, management but society must resist urge to panic. (1990) (0)
- Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression (2006) (0)
- Differental effects of fluticasone propionate on allergen-evoked bronchoconstruction and increased urinary leukotrieneE4, excretion. Authors reply (1994) (0)
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