Bruce A. Yankner
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Bruce A. Yankner's AcademicInfluence.com Rankings
Bruce A. Yanknermedical Degrees
Medical
#2817
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#3256
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Neurology
#264
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#344
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Bruce A. Yanknerbiology Degrees
Biology
#10875
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#14235
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Genetics
#1168
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#1267
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Medical Biology
Bruce A. Yankner's Degrees
- Doctorate Medicine Harvard University
Why Is Bruce A. Yankner Influential?
(Suggest an Edit or Addition)Bruce A. Yankner's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β (2000) (3305)
- Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. (1990) (2029)
- Apoptosis in the nervous system (2000) (1861)
- Gene regulation and DNA damage in the ageing human brain (2004) (1746)
- Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. (1994) (1352)
- Neural mechanisms of ageing and cognitive decline (2010) (1131)
- Mechanisms of Neuronal Degeneration in Alzheimer's Disease (1996) (981)
- Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. (1989) (931)
- Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus (1994) (791)
- Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro (1995) (764)
- Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease (2002) (738)
- SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging (2008) (651)
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 (2015) (612)
- β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding (1995) (600)
- REST and Stress Resistance in Aging and Alzheimer’s Disease (2014) (596)
- Sustained axon regeneration induced by co-deletion of PTEN and SOCS3 (2011) (596)
- Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. (1993) (549)
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease (2010) (537)
- Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis (1998) (530)
- An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. (1991) (530)
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types (2018) (529)
- Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses (2008) (501)
- The aging stress response. (2010) (467)
- Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1* (2006) (455)
- The aging brain. (2008) (413)
- Aging renders the brain vulnerable to amyloid β-protein neurotoxicity (1998) (384)
- Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. (1994) (384)
- Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1 (2000) (374)
- β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation (1999) (370)
- Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome (2002) (360)
- Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. (1999) (351)
- The biology and mechanism of action of nerve growth factor. (1982) (298)
- Evolution of the Aging Brain Transcriptome and Synaptic Regulation (2008) (283)
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types (2018) (267)
- The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. (2005) (244)
- TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging (2018) (240)
- Methodological variables in the assessment of beta amyloid neurotoxicity (1992) (226)
- In vivo neurotoxicity of beta-amyloid [β(1–40)] and the β(25–35) fragment (1992) (218)
- Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. (1998) (213)
- Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease* (2009) (207)
- β-Amyloid and the pathogenesis of alzheimer's disease (1991) (195)
- beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. (1999) (189)
- A RIP Tide in Neuronal Signal Transduction (2002) (170)
- Nerve growth factor potentiates the neurotoxicity of beta amyloid. (1990) (168)
- Negative regulation of Vps34 by Cdk mediated phosphorylation. (2010) (157)
- Cerebral granulomatous angiitis associated with isolation of human T‐lymphotropic virus type III from the central nervous system (1986) (156)
- Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease (2000) (154)
- Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. (1979) (154)
- Amyloid Fibril Toxicity in Alzheimer's Disease and Diabetes a (1996) (150)
- Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium* (2006) (146)
- Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. (2000) (144)
- Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration. (1990) (143)
- Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. (2000) (143)
- REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease (2019) (122)
- Regulation of Lifespan by Neural Excitation and REST (2019) (115)
- The histone demethylase LSD1/KDM1A promotes the DNA damage response (2013) (102)
- An antibody to β amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types (1991) (95)
- Intracellular Accumulation of β-Amyloid in Cells Expressing the Swedish Mutant Amyloid Precursor Protein (*) (1995) (95)
- Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease (1997) (95)
- A γ-Secretase-independent Mechanism of Signal Transduction by the Amyloid Precursor Protein* (2005) (88)
- β‐Amyloid Neurotoxicity in Human Cortical Culture Is Not Mediated by Excitotoxins (1993) (86)
- Inflammation and Alzheimer disease: The good, the bad, and the ugly (2001) (78)
- Developmental Regulation of Presenilin-1 Processing in the Brain Suggests a Role in Neuronal Differentiation* (1997) (70)
- Physiology: Inflammation links ageing to the brain (2013) (62)
- A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. (2005) (54)
- In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. (1992) (53)
- Biosynthesis and mechanism of action of nerve growth factor. (1981) (45)
- reticulum-specific apoptosis and cytotoxicity by amyloid-b (2000) (45)
- Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. (2013) (42)
- Commentary and perspective on studies of beta amyloid neurotoxicity (1992) (39)
- The Pathogenesis of Alzheimer's Disease: Is Amyloid β‐Protein the Beginning or the End? (2000) (39)
- Caspase activity sows the seeds of neuronal death (1999) (37)
- Inhibition of beta-amyloid production by activation of protein kinase C. (1993) (35)
- Presenilin 1 and Presenilin 2 Have Differential Effects on the Stability and Maturation of Nicastrin in Mammalian Brain* (2003) (34)
- Amyloid and Alzheimer's disease—Cause or effect? (1989) (27)
- A century of cognitive decline (2000) (27)
- Neurodegenerative disorders: Neural synchronization in Alzheimer's disease (2016) (26)
- Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses (2021) (25)
- Genetics and biology of the Alzheimer amyloid precursor. (1990) (24)
- Distinct Processing of Endogenous and Overexpressed Recombinant Presenilin 1 (1997) (20)
- Monster plaques: What they tell us about Alzheimer's disease (1998) (14)
- Addendum: REST and stress resistance in ageing and Alzheimer’s disease (2016) (11)
- Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses (2018) (10)
- Slowing Down Aging. (2017) (10)
- The histone demethylase LSD 1 / KDM 1 A promotes the DNA damage response (2013) (9)
- REST and Alzheimer disease (2015) (9)
- Sorting Out Presenilins in Alzheimer’s Disease (2016) (8)
- The adaptive aging brain (2021) (8)
- Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder (2022) (7)
- Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions (2020) (5)
- Amyloid (cid:1) -Protein Toxicity and the Pathogenesis of Alzheimer Disease (2020) (3)
- REST and Stress Resistance in the Aging Kidney (2021) (3)
- Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids (2020) (3)
- 574 Localization and functional significance of presenilin S182 (1996) (3)
- REST and Stress Resistance in Ageing and Alzheimer’s Disease you. Your (2014) (2)
- NGF and Alzheimer's disease—Considerations and caveats (1989) (1)
- The biology and pathology of presenilins (2000) (1)
- Neuronal Regulation of Presenilin-1 Processing (1998) (1)
- Unravelling a tangled mind (2000) (1)
- Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression (2022) (1)
- Expression of the IGF-II Gene in Brain and Muscle (1989) (0)
- Normal proteolytic processing of the presenilins. (2000) (0)
- The report of Nho and colleagues presents evidence for a missense variant in the REST gene (rs3796529) associated with reduced hippocampal volume loss, suggesting that REST expression (2015) (0)
- P1-280 APP-mediated signal transduction in the absence of presenilins (2004) (0)
- 803 A primate model of ßamyloid-induced neurotoxicity and tau phoaphorylation (1996) (0)
- Alzheimer research forum live discussion: meet new players, histone deacetylase and sirtuin--will they help the cell cycle, DNA repair, and gene expression break into Alzheimerology's major league? (2009) (0)
- Regulation of notch-1 cleavage and signaling by presenilin-1 (2000) (0)
- Neuronal Excitatory State Is Linked to Stress Resilience (2021) (0)
- Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autism (2020) (0)
- Nerve growth factor potentiates the neurotoxicity of fi amyloid (2004) (0)
- P4-351 Transthyretin expression in the aging brain and modulation of Aβ deposition (2004) (0)
- Negative Regulation of Vps 34 by Cdk Mediated Phosphorylation Citation (2012) (0)
- S5-02-03 Expression studies (2006) (0)
- 72 Characterization of S182 (presenilin 1) and its effect on ßA4 (1996) (0)
- Presenilins and Notch Signaling Pathway (2002) (0)
- Regulation of endogenous amyloid β-protein production by APOE in a human cortical culture model (2000) (0)
- MECHANISM OF ACTION OF NERVE GROWTH FACTOR1 (1981) (0)
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What Schools Are Affiliated With Bruce A. Yankner?
Bruce A. Yankner is affiliated with the following schools:
