Bruce Ames

Q: What Schools Are Affiliated With Bruce Ames

Bruce Ames is affiliated with the following schools: University of California, Berkeley, Royal Veterinary and Agricultural University, University of New South Wales, University of Oxford, California Institute of Technology, Federal University of Rio de Janeiro, Cornell University

Bruce Ames's AcademicInfluence.com Rankings

Bruce Ames

Biology

#106

World Rank

#193

Historical Rank

#60

USA Rank

Biochemistry

World Rank

#12

Historical Rank

USA Rank

Molecular Biology

#19

World Rank

#19

Historical Rank

#11

USA Rank

biology Degrees

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Biology

Bruce Ames's Degrees

PhD Biochemistry California Institute of Technology
Bachelors Chemistry Cornell University

Why Is Bruce Ames Influential?

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According to Wikipedia, Bruce Nathan Ames is an American biochemist. He is a professor of Biochemistry and Molecular Biology Emeritus at the University of California, Berkeley, and was a senior scientist at Children's Hospital Oakland Research Institute . He is the inventor of the Ames test, a system for easily and cheaply testing the mutagenicity of compounds.

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Bruce Ames's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. (1975) (7356)
Revised methods for the Salmonella mutagenicity test. (1983) (7275)
Oxidants, antioxidants, and the degenerative diseases of aging. (1993) (6156)
A method for determining the sedimentation behavior of enzymes: application to protein mixtures. (1961) (4068)
The free radical theory of aging matures. (1998) (3796)
Bilirubin is an antioxidant of possible physiological importance. (1987) (3332)
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. (1975) (3213)
ASSAY OF INORGANIC PHOSPHATE, TOTAL PHOSPHATE AND PHOSPHATASE (1966) (3055)
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. (1983) (2895)
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. (1981) (2588)
Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. (1973) (2177)
The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. (1960) (2018)
Oxidative damage and mitochondrial decay in aging. (1994) (1962)
Ascorbate is an outstanding antioxidant in human blood plasma. (1989) (1832)
Oxygen radicals and human disease. (1987) (1826)
Normal oxidative damage to mitochondrial and nuclear DNA is extensive. (1988) (1723)
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. (1997) (1470)
An improved bacterial test system for the detection and classification of mutagens and carcinogens. (1973) (1465)
The causes and prevention of cancer. (1995) (1318)
Antioxidant defenses and lipid peroxidation in human blood plasma. (1988) (1229)
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. (1990) (1080)
Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium (1985) (1000)
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids. (1975) (981)
Oxidative Decay of DNA* (1997) (965)
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. (1983) (830)
Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. (1990) (829)
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. (1976) (818)
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. (1991) (791)
Antioxidant activity of albumin-bound bilirubin. (1987) (751)
gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. (2001) (747)
A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens. (1982) (737)
Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. (1988) (710)
Oxidative DNA damage and senescence of human diploid fibroblast cells. (1995) (696)
Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. (1989) (694)
Positive selection for loss of tetracycline resistance (1980) (689)
DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. (1998) (686)
Endogenous oxidative DNA damage, aging, and cancer. (1989) (686)
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? (2005) (653)
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. (1994) (638)
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. (1990) (592)
Oxidative damage to DNA: relation to species metabolic rate and life span. (1988) (572)
Identifying environmental chemicals causing mutations and cancer. (1979) (558)
DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. (2001) (555)
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid (2002) (548)
Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. (1985) (525)
Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. (1991) (508)
γ-Tocopherol traps mutagenic electrophiles such as NOx and complements α-tocopherol: Physiological implications (1997) (497)
A carcinogenic potency database of the standardized results of animal bioassays (1984) (487)
Smoking and low antioxidant levels increase oxidative damage to sperm DNA. (1996) (479)
Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine. (1977) (474)
γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells (2000) (472)
Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography. (1982) (471)
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. (1998) (457)
Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. (2000) (451)
Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins. (1986) (444)
Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. (1997) (439)
Hair dyes are mutagenic: identification of a variety of mutagenic ingredients. (1975) (433)
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. (2007) (425)
OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. (1989) (425)
Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats (1996) (406)
Mitochondrial decay in aging. (1995) (405)
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? (2008) (402)
The Detection of Chemical Mutagens with Enteric Bacteria (1971) (401)
Micronutrients prevent cancer and delay aging. (1998) (381)
Dietary pesticides (99.99% all natural). (1990) (372)
Mutagenicity of quinones: pathways of metabolic activation and detoxification. (1984) (371)
DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. (1993) (370)
Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. (2005) (362)
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line (2002) (358)
Dietary carcinogens and anti-carcinogens. (1984) (354)
Assays for 8-hydroxy-2'-deoxyguanosine: a biomarker of in vivo oxidative DNA damage. (1991) (347)
AppppA, heat-shock stress, and cell oxidation. (1983) (343)
Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography. (1987) (342)
Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage (2006) (337)
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. (2002) (336)
Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress (2002) (335)
Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage. (1984) (334)
Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens. (1972) (327)
Endogenous DNA damage as related to cancer and aging. (1989) (327)
Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior (2015) (324)
Is docosahexaenoic acid, an n−3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals (2005) (321)
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism (2014) (320)
Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats (2002) (316)
Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. (1994) (313)
Oxidants Are a Major Contributor to Aging a (1992) (311)
Bacterial defenses against oxidative stress. (1990) (310)
γ‐Tocopherol, but not α‐tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats (2003) (308)
An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. Purification and properties. (1989) (305)
Part X • Chapter 27 – Oxidants and aging (2000) (304)
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. (1994) (301)
A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. (2000) (292)
(R)‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate (1999) (288)
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. (1992) (286)
Procedure for Identifying Nonsense Mutations (1968) (285)
Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l- carnitine and/or R-α-lipoic acid (2002) (284)
Ascorbate: the most effective antioxidant in human blood plasma. (1990) (278)
Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. (1998) (278)
Detection of mutagenic activity in cigarette smoke condensates. (1974) (274)
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males (2013) (274)
The Histidine Operon (1963) (270)
Are vitamin and mineral deficiencies a major cancer risk? (2002) (270)
Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. (1992) (267)
AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress (1984) (266)
Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. (1977) (263)
Nature's chemicals and synthetic chemicals: comparative toxicology. (1990) (260)
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways (2008) (256)
Endogenous oxidative damage of deoxycytidine in DNA. (1992) (254)
Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage. (1996) (253)
Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma. (1988) (251)
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. (2003) (250)
Mutagenesis and carcinogenesis: Endogenous and exogenous factors (1989) (248)
An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp (1989) (247)
Measurement of antioxidants in human blood plasma. (1994) (245)
Compounds Which Serve as the Sole Source of Carbon or Nitrogen for Salmonella typhimurium LT-2 (1969) (235)
Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. (2000) (233)
Localized mutagenesis of any specific small region of the bacterial chromosome. (1971) (232)
Assay of aldehydes from lipid peroxidation: gas chromatography-mass spectrometry compared to thiobarbituric acid. (1997) (231)
The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments. (1984) (231)
Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency. (1975) (228)
Mitochondrial Aging: Open Questions a (1998) (226)
Classification of aminotransferase (C gene) mutants in the histidine operon. (1966) (216)
Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens (1972) (212)
Delaying Brain Mitochondrial Decay and Aging with Mitochondrial Antioxidants and Metabolites (2002) (208)
Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. (1987) (207)
Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress. (1989) (205)
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. (2004) (199)
Endogenous oxidative damage of mtDNA. (1999) (199)
8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. (1999) (198)
A new Salmonella tester strain, TA97, for the detection of frameshift mutagens. A run of cytosines as a mutational hot-spot. (1982) (196)
Time to Talk SENS: Critiquing the Immutability of Human Aging (2002) (195)
DIETARY CARCINOGENESIS AND ANTICARCINOGENESIS (1983) (194)
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. (2005) (193)
Antioxidant activities of bile pigments: biliverdin and bilirubin. (1990) (192)
Frameshift mutagenesis in Salmonella. (1966) (191)
Antioxidant status and indexes of oxidative stress during consecutive days of exercise. (1993) (191)
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging (2002) (191)
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? (2009) (189)
Oxidative damage increases with age in a canine model of human brain aging (2002) (188)
Iron Uptake in Salmonella typhimurium: Utilization of Exogenous Siderochromes as Iron Carriers (1972) (183)
Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants (1978) (183)
Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide. (1975) (181)
gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. (1997) (178)
Iron Transport in Salmonella typhimurium: Mutants Blocked in the Biosynthesis of Enterobactin (1970) (176)
[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. (1972) (174)
[54] In vivo oxidative DNA damage : measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection (1990) (172)
Micronutrient Deficiencies: A Major Cause of DNA Damage (1999) (171)
Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora. (1980) (171)
The case for strategic international alliances to harness nutritional genomics for public and personal health† (2005) (170)
Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. (1986) (169)
Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. (1994) (167)
gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. (2000) (165)
Rodent carcinogens: setting priorities. (1992) (162)
Age‐associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes—reversal with (R)‐α‐lipoic acid supplementation (1998) (162)
Histidine regulation in Salmonella typhimurium. XI. The percentage of transfer RNA His charged in vivo and its relation to the repression of the histidine operon. (1972) (161)
The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. (2001) (160)
Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection. (1997) (159)
Both iron deficiency and daily iron supplements increase lipid peroxidation in rats. (2000) (153)
Assay of malondialdehyde in biological fluids by gas chromatography-mass spectrometry. (1994) (152)
An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring (2006) (152)
The first step of histidine biosynthesis. (1961) (152)
COORDINATE REPRESSION OF THE SYNTHESIS OF FOUR HISTIDINE BIOSYNTHETIC ENZYMES BY HISTIDINE. (1959) (151)
Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. (1987) (150)
A simple method for the detection of mutagens in urine: studies with the carcinogen 2-acetylaminofluorene. (1974) (150)
Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. (1987) (149)
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. (2007) (149)
Alkyl hydroperoxide reductase from Salmonella typhimurium. Sequence and homology to thioredoxin reductase and other flavoprotein disulfide oxidoreductases. (1990) (148)
Histidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase. (1966) (148)
Regulation of nonspecific acid phosphatase in Salmonella: phoN and phoP genes (1979) (148)
Immunocompetence and oxidant defense during ascorbate depletion of healthy men. (1991) (147)
Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. (2003) (147)
Sunlight ultraviolet and bacterial DNA base ratios. (1970) (146)
Folate Deficiency Inhibits the Proliferation of Primary Human CD8+ T Lymphocytes In Vitro1 (2004) (145)
Heme Deficiency Selectively Interrupts Assembly of Mitochondrial Complex IV in Human Fibroblasts (2001) (144)
Hydroxymethyluracil DNA glycosylase in mammalian cells. (1984) (143)
Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. (2000) (143)
Chromosomal alterations affecting the regulation of histidine biosynthetic enzymes in Salmonella. (1963) (142)
Immunoaffinity isolation of urinary 8-hydroxy-2'-deoxyguanosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2'-deoxyguanosine in DNA by polyclonal antibodies. (1991) (141)
The genetic control of the enzymes of histidine biosynthesis in Salmonella typhimurium. (1960) (139)
N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts* (2000) (138)
The Paper Chromatography of Imidazoles (1952) (138)
Compatibility of organic solvents with the Salmonella/microsome test. (1981) (137)
The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. (1993) (136)
The Histidine Operon and Its Regulation (1971) (135)
Toxic hydroperoxides in intravenous lipid emulsions used in preterm infants. (1993) (135)
Prolonging healthy aging: Longevity vitamins and proteins (2018) (134)
Complete analysis of tRNA-modified nucleosides by high-performance liquid chromatography: the 29 modified nucleosides of Salmonella typhimurium and Escherichia coli tRNA. (1983) (133)
A role for supplements in optimizing health: the metabolic tune-up. (2004) (132)
Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. (2002) (130)
Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease (2005) (129)
Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers. (2001) (127)
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats (2008) (126)
Mode of action of the herbicide, 3-amino-1,2,4-triazole(amitrole): inhibition of an enzyme of histidine biosynthesis. (1965) (126)
Detection and classification of mutagens: a set of base-specific Salmonella tester strains. (1994) (125)
Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine. (1966) (124)
International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Publication No. 12. Inhibitors of mutagenesis and their relevance to carcinogenesis. Report by ICPEMC Expert Group on Antimutagens and Desmutagens. (1986) (123)
Classifying mutagens as to their specificity in causing the six possible transitions and transversions: a simple analysis using the Salmonella mutagenicity assay. (1986) (119)
Mutagenicity of inorganic compounds in Salmonella typhimurium: arsenic, chromium and selenium (1978) (118)
2 DNA damage in folate deficiency (1995) (117)
Environmental Pollution, Pesticides, and the Prevention of Cancer: Misconceptions 1 (1997) (117)
Positive selection of mutants with deletions of the gal-chl region of the Salmonella chromosome as a screening procedure for mutagens that cause deletions (1975) (116)
Biosynthesis of pseudouridine in transfer ribonucleic acid. (1974) (115)
Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection. (1989) (114)
A procedure for rapid extraction and high-pressure liquid chromatographic separation of the nucleotides and other small molecules from bacterial cells. (1982) (114)
Target sequences for mutagenesis in Salmonella histidine-requiring mutants. (1986) (113)
The OxyR regulon (1990) (112)
Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging (2011) (112)
Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome. (1990) (112)
The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. (2002) (112)
Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. (2001) (112)
Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium. (1988) (110)
BIOCHEMICAL ASPECTS OF GENETICS: THE OPERON. (1964) (110)
Comparison of the Effects of l‐Carnitine and Acetyl‐l‐Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats (2004) (109)
'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status. (1997) (108)
Spontaneous and mutagen-induced deletions: mechanistic studies in Salmonella tester strain TA102. (1984) (107)
Presence of polyamines in certain bacterial viruses. (1958) (107)
What do animal cancer tests tell us about human cancer risk?: Overview of analyses of the carcinogenic potency database. (1998) (105)
The oxidation of blood plasma and low density lipoprotein components by chemically generated singlet oxygen. (1993) (104)
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts (2008) (104)
Cancer prevention and diet: help from single nucleotide polymorphisms. (1999) (104)
The effect of acetyl-L-carnitine and R-α-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease (2009) (103)
Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. (2005) (103)
A modified nucleotide in tRNA as a possible regulator of aerobiosis: Synthesis of cis-2-methyl-thioribosylzeatin in the tRNA of Salmonella (1984) (103)
Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison (2004) (103)
Delaying the Mitochondrial Decay of Aging with Acetylcarnitine (2004) (102)
7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection. (1988) (102)
Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. (2008) (102)
ZTP (5-amino 4-imidazole carboxamide riboside 5′-triphosphate): A proposed alarmone for 10-formyl-tetrahydrofolate deficiency (1982) (101)
Diadenosine 5',5"'-P1,P4-tetraphosphate and related adenylylated nucleotides in Salmonella typhimurium. (1983) (101)
Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. (1971) (100)
Some Tautologous Aspects of the Comparison of Carcinogenic Potency in Rats and Mice (1985) (100)
Delaying the Mitochondrial Decay of Aging (2004) (99)
Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl‐l‐Carnitine and N‐tert‐Butyl‐α‐phenyl‐nitrone a (1998) (98)
Background levels of DNA damage in the population. (1986) (98)
Assay of lipid hydroperoxides using high-performance liquid chromatography with isoluminal chemiluminescence detection. (1990) (97)
Illicit transport: the oligopeptide permease. (1973) (96)
The Causes and Prevention of Cancer: The Role of Environment (1998) (95)
[147] Enzymes and intermediates of histidine biosynthesis in Salmonella typhimurium (1971) (95)
Inhibitors of mutagenesis and their relevance to carcinogenesis (1986) (93)
Oxidative damage to plasma constituents by ozone (1992) (91)
Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-l-carnitine (2009) (91)
DNA damage in folate deficiency. (1995) (90)
Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production. (1997) (90)
An adduct between peroxynitrite and 2'-deoxyguanosine: 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine. (1996) (89)
LIPID PEROXIDATION AND OXIDATIVE DAMAGE TO DNA1 (1982) (88)
The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program. (1991) (88)
Oxidative mechanisms of toxicity of low-intensity near-UV light in Salmonella typhimurium (1987) (86)
Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes. (2003) (85)
Near-UV stress in Salmonella typhimurium: 4-thiouridine in tRNA, ppGpp, and ApppGpp as components of an adaptive response (1988) (84)
Carcinogens are mutagens: A simple test system (1975) (82)
Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants. (1967) (82)
Validation of the Salmonella test: a reply to Rinkus and Legator. (1981) (79)
Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine. (1990) (78)
An apaH mutation causes AppppA to accumulate and affects motility and catabolite repression in Escherichia coli. (1989) (78)
The metabolic tune-up: metabolic harmony and disease prevention. (2003) (77)
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. (1974) (77)
(R)-α-Lipoic Acid Reverses the Age-Associated Increase in Susceptibility of Hepatocytes to tert-Butylhydroperoxide both In Vitro and In Vivo (2000) (77)
Resolution and purification of three periplasmic phosphatases of Salmonella typhimurium (1977) (76)
(R)-α-Lipoic Acid Protects Retinal Pigment Epithelial Cells from Oxidative Damage (2005) (76)
Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. (2002) (76)
Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy. (2000) (75)
Detection and quantification of oxidative adducts of mitochondrial DNA. (1996) (74)
Iron Accumulation during Cellular Senescence (2004) (73)
Detection of lipid hydroperoxides and hydrogen peroxide at picomole levels by an HPLC and isoluminol chemiluminescence assay. (1987) (71)
Analysis of uracil in DNA by gas chromatography-mass spectrometry. (1994) (71)
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Daily Supplementation with Iron Increases Lipid Peroxidation in Young Women with Low Iron Stores (2008) (70)
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Iron accumulation during cellular senescence in human fibroblasts in vitro. (2003) (68)
6 – REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST (1984) (67)
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γ‐Tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma (2008) (62)
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Optimal micronutrients delay mitochondrial decay and age-associated diseases (2010) (61)
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Quantitation of age-related mitochondrial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans. (1998) (59)
Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. (2004) (57)
Charles S. Mott prize. The detection of environmental mutagens and potential carcinogens (1984) (57)
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The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications. (1983) (56)
Detection of picomole levels of lipid hydroperoxides using a dichlorofluorescein fluorescent assay. (1984) (55)
Maternal Dietary Zinc Influences DNA Strand Break and 8-Hydroxy-2′-Deoxyguanosine Levels in Infant Rhesus Monkey Liver (1993) (55)
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A simpler, more robust method for the analysis of 8-oxoguanine in DNA. (2000) (52)
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The multiplication of T4rII phage in E. coli K12(λ) in the presence of polyamines (1965) (44)
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γ‐Tocopherol Induces Apoptosis in Androgen‐Responsive LNCaP Prostate Cancer Cells via Caspase‐Dependent and Independent Mechanisms (2004) (43)
Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos. (1996) (43)
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Antioxidant Prevention of Birth Defects and Cancer (1994) (31)
Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts (2008) (30)
Chronic Ethanol Perturbs Testicular Folate Metabolism and Dietary Folate Deficiency Reduces Sex Hormone Levels in the Yucatan Micropig1 (2007) (30)
Some New Naturally Occurring Imidazoles Related to the Biosynthesis of Histidine1 (1953) (30)
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g-Tocopherol and its major metabolite , in contrast to a-tocopherol , inhibit cyclooxygenase activity in macrophages and epithelial cells (2000) (20)
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Nutritional Prevention of DNA Damage to Sperm and Consequent Risk Reduction in Birth Defects and Cancer in Offspring (1997) (18)
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Concentration of mutagens from urine by adsorption with the nonpolar resin XAD-2 : Cigarette smokers have mutagenic urine ( detecting carcinogens in urine or aqueous liquids / Salmonella test ) (17)
Oxidative DNA damage as related to cancer and aging. (1986) (16)
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Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India (2009) (15)
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Histidyl-Transfer Ribonucleic Acid Synthetase Mutants Requiring a High Internal Pool of Histidine for Growth (1973) (13)
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The Histidine Operon of Salmonella typhimurium (1974) (9)
The operon concept in bacteria and in higher organisms. (1967) (9)
Pollution, Pesticides, and Cancer (1992) (9)
Fe2+ Induces a Transient Ca2+ Release from Rat Liver Mitochondria (2002) (9)
The use of mechanistic data in the risk assessments of ten chemicals: an introduction to the chemical-specific reviews. (1996) (9)
The Detection and Hazards of Environmental Carcinogens/Mutagens (1979) (9)
A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study (2018) (9)
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Fe(2+) induces a transient Ca(2+) release from rat liver mitochondria. (2002) (7)
Sensitive fluorographic detection of 3H and 14C on chromatograms using methyl anthranilate as a scintillant. (1983) (7)
Detection of DNA base damage by 32P-postlabelling: TLC separation of 5'-deoxynucleoside monophosphates. (1986) (7)
DNA Damage to Sperm from Micronutrient Deficiency May Increase the Risk of Birth Defects and Cancer in Offspring (2001) (7)
Increased leucocyte apoptosis in transfused β‐thalassaemia patients (2013) (6)
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Natural carcinogens and dioxin. (1991) (6)
Oral Arginine Increases Erythrocyte Glutathione Levels in Sickle Cell Disease: Implications for Pulmonary Hypertension. (2006) (6)
Response : Carcinogenicity of Aflatoxins (1987) (6)
Oxidative Mechanisms ofToxicity ofLow-Intensity Near-UV Light inSalmonella typhimurium (1987) (6)
Anti-Oxidant Treatment with α-Lipoic Acid and Acetyl L-Carnitine in Hemoglobinopathies. (2007) (5)
Evidence Required for Causal Inferences about Effects of Micronutrient Deficiencies during Development on Brain Health DHA, Choline, Iron, and Vitamin D (2009) (5)
ENVIRONMENTAL CHEMICALS CAUSING CANCER AND GENETIC BIRTH DEFECTS (1978) (5)
A strategy to minimize human exposure to environmental chemicals causing cancer and genetic birth defects (1979) (5)
U.S.-JAPAN MEETING ON “OXYGEN RADICALS IN CANCER” (1986) (5)
Mutagens, carcinogens, and anti-carcinogens. (1982) (5)
Immunochemical identification of a tRNA-independent cytokinin-like compound in Salmonella typhimurium. (1989) (5)
Increased oxidative DNA damage following partial hepatectomy (1990) (4)
Adrenalectomy Causes Oxidative Damage and Monoamine Increase in the Brain of Rats and Enhances Immobilization Stress-Induced Oxidative Damage and Neurotransmitter Changes (1998) (4)
Mutagenicity of Selected Chemicals in the Salmonella/Microsome Mutagenicity Test (1981) (4)
Nature's pesticides. (1992) (4)
Paracelsus to parascience : the environmental cancer distraction Paracelsus to parascience : the environmental cancer distraction-Télécharger la publication (2017) (4)
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AN OVERVIEW OF THE SALMONELLA MUTAGENICITY TEST (1980) (4)
The importance of ranking possible carcinogenic hazards using HERP. (1990) (4)
Delaying Aging with Mitochondrial Micronutrients and Antioxidants (2001) (4)
Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk (2020) (4)
Effects of a peroxisomal proliferator (PP) on plasma and tissue levels of coenzyme Q9 (CoQ), other antioxidants, and oxidative damage to DNA (oxo8dG): evidence that PPs deplete antioxidants and increase oxidative damage to DNA. (1994) (3)
Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis (1990) (3)
Investigations of mitochondrial dna point mutations and mitochondrial oxidants in aging and disease (1997) (3)
Preventing cognitive decline in elderly demented/depressed patients and in ApoE4 mouse as a model of human Alzheimer's disease by feeding acetyl-l-carnitine and lipoic acid (2009) (3)
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Gas phase cigarette smoke (CS) induces lipid peroxidation in human plasma (1990) (3)
Pesticide residues and cancer causation (1989) (3)
Control of Oxidant-Stress and Inflammation by Iron Chelators Deferasirox (ICL670) or Deferoxamine in β-Thalassemia: An Ancillary Study of the Novartis CICL670A0107 Trial. (2005) (2)
Development of a sensitive assay for detection of uracil in DNA. (1993) (2)
Gordon M. Tomkins (1926–1975) (1977) (2)
What are the major carcinogens in the etiology of human cancer? Environmental pollution, natural carcinogens, and the causes of human cancer: six errors. (1989) (2)
Part 2—Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India (2009) (2)
The predictive value for animal carcinogenicity of mutagenicity in the Salmonella/microsome test (1978) (2)
Effect of the alpha-hydrazino analogue of histidine on histidine transport and arginine biosynthesis. (1966) (2)
Inhibition of SV40 Replication In Vitro by Poly(ADP-Ribosyl)ated Diadenosine Tetraphosphate (1989) (2)
Erythrocyte Glutathione Depletion Is Associated with Severity of Anemia and Pulmonary Hypertension in Patients with Sickle Cell Disease. (2006) (2)
Mitochondrial Nutrients: Reducing Mitochondrial Decay to Delay or Treat Cognitive Dysfunction, Alzheimer’s Disease, and Parkinson’s Disease (2005) (2)
Comprehensive progress report, July 1, 1974-September 30, 1977 (1977) (2)
Toxic Unbound Iron and Membrane Injury in b-Thalassemia and Sickle Cell Disease: Elevated Non-Transferrin Bound Iron (NTBI) and Malondialdehyde (MDA). (2004) (2)
514 OXIDANT STRESS IN HUMANSDURING CONSECUTIVE DAYS OF EXERCISE (1990) (1)
An inexpensive Luer-fitting chromatographic column. (1967) (1)
Zinc Deficiency and Microtubule Function in Prostate Cells (2006) (1)
10 – ENVIRONMENTAL CHEMICALS CAUSING CANCER AND GENETIC BIRTH DEFECTS: MUTAGENICITY TESTING FOR REACTIVE METABOLITES (1978) (1)
Leukocyte Apoptosis and Inflammation in Iron-Overloaded Patients with Sickle Cell Disease or β-Thalassemia: A Mechanism for Increased Stroke and Disease Severity in Sickle Cell Disease. (2006) (1)
Cancer, Aging, and Endogenous DNA Damage (1989) (1)
Environmental Chemicals Causing Cancer and Genetic Birth Defects: Mutagenicity Testing for Reactive Metabolites* (1979) (1)
Host Nrf2 –glutathione Redox Dysregulation Precedes TNF-α Elevation and Predicts Severity of Graft Versus Host Disease in Experimental Transplantation (2012) (1)
Toxic Carbonyl Compounds (1998) (1)
Spontaneous andmutagen-induced deletions: Mechanistic studies in Salmonella tester strain TA102 (single-strand breaks/mutagenic gyrase inhibitors/DNA repair/multicopy plasmid) (1984) (1)
Preface (2020) (1)
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Musings in the twilight of my career. (2021) (1)
pulmonary hypertension in sickle cell disease Erythrocyte glutamine depletion, altered redox environment, and (2009) (1)
Effects of ozone on human blood plasma (1991) (1)
Oxidative damage and mitochondrial decay in aging ( bIoenergetics / mltodcndra DNA / arwdbipn / acetyl-L-cnitlne / neurodeneration ) (1)
Ames agrees with mom's advice: eat your fruits and vegetables. (1995) (1)
Antioxidant activity of albumin-bound bilirubin ( reactive oxygen species / plasma antioxidants / biliverdin / evolution ) (1)
Carcinogens and anti-carcinogens. (1982) (1)
The identification of chemicals in the environment causing mutations and cancer (1980) (1)
Leukocyte Apoptosis and Mitochondrial Dysfunction in β-Thalassemia Patients Treated with Deferasirox or Deferoxamine. (2007) (1)
The Causes of Aging and Cancer: The Misinterpretation of Animal Cancer Tests (1996) (1)
Near-UVStress inSalmonella typhimurium: 4-Thiouridine intRNA, ppGpp,andApppGppasComponents ofan Adaptive Response (1988) (1)
Evidence-based decision making on micronutrients and chronic disease : long-term randomized controlled trials are not enough. Authors' reply (2007) (1)
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Heightened Sulfur Amino Acid Oxidation in Plasma and Erythrocytes in β-Thalassemia Major. (2009) (0)
THE BIOSYNTHESIS OF HISTIDINE (2003) (0)
Is oxidative stress an initiator of mitochondrial failure and vascular hypoperfusion during aging and Alzheimer disease? Present and future (2009) (0)
The biosynthesis of histidine in Neurospora crassa (1953) (0)
Presence of Polyamines in Certain Bacterial Viruses (1958) (0)
γ-Tocopherol, the Neglected Form of Vitamin E: New Functions, New Interest (2002) (0)
Q XVII B.4 The prevention of DNA damage: The role of nutrition (1997) (0)
Possible Carcinogenic Hazards from Natural and Synthetic Chemicals: Setting Priorities (2018) (0)
Vitamin E forms inhibited IL‐13‐induced eotaxin secretion by blocking stat6 activation in human lung epithelial A549 cells (2008) (0)
Multicomponent Nutrient Bar Promotes Weight Loss and Improves Dyslipidemia and Insulin Resistance (2019) (0)
Alterations of NAD and adenylyl dinucleotide metabolism in Chediak-Higashi Syndrome fibroblasts (1988) (0)
Evidence for a hydroperoxide reductase in plasma (1990) (0)
Response : Paleolithic Diet, Evolution, and Carcinogens (1987) (0)
Vitamin and mineral inadequacy accelerates aging-associated diseases (2013) (0)
Illicit Transport : The Oligopeptide Permease ( histidinol phosphate transport / amino-acid analogue transport / Salmonella ) (0)
Histone deacetylase7 regulates subcellular localization of HIF‐1α upon transition from hypoxia to normoxia (re‐oxygenation) (2006) (0)
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K m ): relevance to genetic disease and polymorphisms 1–3 (2002) (0)
Response : Evolution of DNA Base Compositions in Microorganisms (1972) (0)
Carcinogens areMutagens: A Simple TestSystemCombining Liver Homogenates forActivation andBacteria forDetection (frameshift mutagens/aflatoxin/benzo(a)pyrene/acetylaminofluorene) (1973) (0)
Enough Is Enough (2014) (0)
Response : Carcinogenicity Tests (1976) (0)
Carcinogens and aging (1990) (0)
Possible Regulation of the Salmonella typhimurium Histidine Operon by Adenosine Triphosphate Phosphoribosyltransferase : Large Metabolic Effects (2003) (0)

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