Bruce M. Spiegelman
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American biochemist and cell biologist
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Bruce M. Spiegelmanbiology Degrees
Biology
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Cell Biology
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Biochemistry
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Biology
Bruce M. Spiegelman's Degrees
- PhD Biochemistry Princeton University
- Bachelors Biochemistry Princeton University
Why Is Bruce M. Spiegelman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Bruce Michael Spiegelman is an American biochemist and cell biologist. Since 2008, Spiegelman has been the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at the Dana–Farber Cancer Institute and Harvard Medical School, and director of the Center for Metabolism and Chronic Disease at the Dana-Farber.
Bruce M. Spiegelman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. (1993) (7475)
- PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes (2003) (6859)
- Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 (1999) (3848)
- A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis (1998) (3709)
- Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. (1995) (3606)
- Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor (1994) (3300)
- Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human (2012) (2790)
- A PGC1α-dependent myokine that drives browning of white fat and thermogenesis (2012) (2734)
- 15-Deoxy-Δ 12,14-Prostaglandin J 2 is a ligand for the adipocyte determination factor PPARγ (1995) (2718)
- IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance (1996) (2631)
- Obesity and the Regulation of Energy Balance (2001) (2320)
- AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity (*) (1996) (2278)
- mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. (1994) (2237)
- Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres (2002) (2201)
- PRDM16 controls a brown fat/skeletal muscle switch (2008) (2115)
- Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators (2006) (2050)
- Metabolic control through the PGC-1 family of transcription coactivators. (2005) (2040)
- Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. (2003) (2005)
- Adipocytes as regulators of energy balance and glucose homeostasis (2006) (2000)
- Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1 (2005) (1937)
- Fat and beyond: the diverse biology of PPARgamma. (2008) (1879)
- Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 (2001) (1845)
- PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro (1999) (1751)
- PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. (1998) (1748)
- What We Talk About When We Talk About Fat (2014) (1673)
- AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α (2007) (1663)
- Towards a molecular understanding of adaptive thermogenesis (2000) (1513)
- Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. (2005) (1420)
- CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 (2001) (1376)
- Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. (2002) (1310)
- Molecular regulation of adipogenesis. (2000) (1292)
- Adipogenesis and Obesity: Rounding Out the Big Picture (1996) (1279)
- A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis (2012) (1278)
- FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. (2012) (1278)
- Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction (2003) (1277)
- Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. (1994) (1259)
- C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. (2002) (1248)
- Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice (2004) (1204)
- Tumor necrosis factor alpha inhibits signaling from the insulin receptor. (1994) (1186)
- Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link (1994) (1133)
- 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. (1995) (1104)
- Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ (1996) (1103)
- PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth* (2001) (1089)
- Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. (2006) (1081)
- Differentiation and reversal of malignant changes in colon cancer through PPARγ (1998) (1071)
- Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. (2011) (1062)
- Transcriptional control of brown fat determination by PRDM16. (2007) (1050)
- ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. (1996) (1023)
- HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α (2008) (1006)
- AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. (2007) (996)
- TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation (2005) (960)
- International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006) (946)
- PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. (1999) (931)
- PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription (2006) (921)
- The role of exercise and PGC1α in inflammation and chronic disease (2008) (919)
- Terminal differentiation of human breast cancer through PPAR gamma. (1998) (900)
- Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding Protein (1996) (884)
- Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity (1999) (883)
- Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. (2013) (856)
- Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. (1994) (829)
- Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. (1998) (788)
- Molecular mechanisms of cancer development in obesity (2011) (770)
- Adaptive thermogenesis in adipocytes: is beige the new brown? (2013) (766)
- Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. (2001) (744)
- Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5 (2010) (728)
- Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. (2003) (715)
- Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch (2014) (715)
- Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. (1997) (691)
- Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. (2005) (686)
- Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis (2014) (681)
- Brown and Beige Fat: Physiological Roles beyond Heat Generation. (2015) (680)
- Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1 (2001) (670)
- PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]. (2000) (670)
- Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. (1996) (665)
- Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. (1995) (647)
- PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. (2012) (645)
- Pleiotropic effects of a null mutation in the c-fos proto-oncogene (1992) (642)
- An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle (2003) (636)
- Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging (2009) (617)
- Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle (2004) (614)
- ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation (1993) (611)
- PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene (1995) (605)
- Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP (2005) (602)
- Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. (2006) (590)
- ADD1/SREBP1 activates PPARγ through the production of endogenous ligand (1998) (586)
- Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals* (2007) (564)
- ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose (1999) (562)
- Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. (1995) (552)
- PAX8-PPARγ1 Fusion in Oncogene Human Thyroid Carcinoma (2000) (550)
- Activation of PPARγ coactivator-1 through transcription factor docking (1999) (545)
- PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. (2013) (541)
- Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis (2003) (535)
- Common DNA binding site for Fos protein complexesand transcription factor AP-1 (1988) (534)
- A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat (2015) (524)
- Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. (1999) (519)
- A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy (2012) (514)
- p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene (2004) (512)
- Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor* (2002) (489)
- Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer (1999) (486)
- Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells* (2003) (486)
- Differential activation of adipogenesis by multiple PPAR isoforms. (1996) (486)
- PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. (2001) (485)
- Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. (1995) (476)
- Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia (2014) (474)
- The role of PPAR-γ in macrophage differentiation and cholesterol uptake (2001) (465)
- Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. (2000) (458)
- Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. (2008) (454)
- Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model (2018) (440)
- Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. (2003) (437)
- Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos (1987) (436)
- Transcriptional Control of Preadipocyte Determination by Zfp423 (2010) (435)
- Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism (1999) (431)
- β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. (2014) (428)
- Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase* (1996) (425)
- Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex (2009) (422)
- PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. (1997) (422)
- Fibronectin modulation of cell shape and lipogenic gene expression in 3t3-adipocytes (1983) (421)
- Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. (2015) (418)
- Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation (2000) (406)
- Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. (1983) (405)
- Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1 (2001) (401)
- A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. (1993) (397)
- Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. (1994) (396)
- An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. (2003) (395)
- Initiation of myoblast to brown fat switch by a PRDM 16 – C / EBP-b transcriptional complex (2009) (392)
- A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation* (2000) (385)
- Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation (2011) (384)
- Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation* (2000) (381)
- Transcriptional control of brown fat development. (2010) (378)
- Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. (1999) (377)
- The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. (2007) (376)
- c-fos is required for malignant progression of skin tumors (1995) (376)
- Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. (2008) (373)
- Biological Control through Regulated Transcriptional Coactivators (2004) (373)
- C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling (2010) (372)
- Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. (1987) (371)
- Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. (2004) (368)
- A smooth muscle-like origin for beige adipocytes. (2014) (365)
- Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. (1992) (362)
- Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. (1992) (361)
- Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α (2005) (350)
- Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa (1994) (347)
- Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. (2012) (342)
- Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain (1995) (337)
- Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. (1996) (337)
- New Advances in Adaptive Thermogenesis: UCP1 and Beyond. (2019) (335)
- Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α (2006) (329)
- Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. (1997) (328)
- Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. (2004) (326)
- Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. (2008) (320)
- Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 (2016) (316)
- ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. (1998) (308)
- Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (2018) (305)
- Cellular transformation and malignancy induced by ras require c-jun (1996) (304)
- Severely impaired adipsin expression in genetic and acquired obesity. (1987) (302)
- APC-dependent suppression of colon carcinogenesis by PPARγ (2002) (298)
- PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy (2007) (297)
- Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk (2007) (294)
- Transcription coactivator TRAP220 is required for PPARγ2-stimulated adipogenesis (2002) (292)
- Transcriptional control of brown adipocyte development and physiological function--of mice and men. (2009) (290)
- Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells (2006) (289)
- miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. (2014) (289)
- Adipsin and an endogenous pathway of complement from adipose cells. (1992) (286)
- Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. (1993) (285)
- C/EBP induces adipogenesis through PPAR: a unified pathway (2002) (285)
- Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. (2003) (284)
- Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. (1986) (283)
- TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis (2012) (282)
- Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 Adipocytes (1982) (279)
- Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. (2002) (275)
- Adipsin Is an Adipokine that Improves β Cell Function in Diabetes (2014) (274)
- Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism (2008) (270)
- Development of insulin resistance in mice lacking PGC-1α in adipose tissues (2012) (266)
- Peroxisome Proliferator-Activated Receptor-Coactivator 1 ( PGC-1 ) : Transcriptional Coactivator and Metabolic Regulator (2003) (263)
- Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. (2003) (260)
- Functional Antagonism between CCAAT/Enhancer Binding Protein-α and Peroxisome Proliferator-activated Receptor-γ on the Leptin Promoter* (1997) (257)
- The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. (2011) (254)
- Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. (2003) (254)
- An Erk/Cdk5 axis controls the diabetogenic actions of PPARγ (2014) (247)
- Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene* (1997) (245)
- Identification of Conserved cis-Elements and Transcription Factors Required for Sterol-regulated Transcription of Stearoyl-CoA Desaturase 1 and 2* (1999) (231)
- Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. (2011) (230)
- Use of the Peroxisome Proliferator-Activated Receptor (PPAR) γ Ligand Troglitazone as Treatment for Refractory Breast Cancer: A Phase II Study (2003) (229)
- Differential Regulation of the p80 Tumor Necrosis Factor Receptor in Human Obesity and Insulin Resistance (1997) (228)
- Genetic Analysis of Adipogenesis through Peroxisome Proliferator-activated Receptor γ Isoforms* (2002) (228)
- Fat cells directly sense temperature to activate thermogenesis (2013) (228)
- Through thick and thin: Wasting, obesity, and TNFα (1993) (224)
- PGC-1β in the Regulation of Hepatic Glucose and Energy Metabolism* (2003) (220)
- The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. (2001) (217)
- A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. (1990) (215)
- Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. (2005) (209)
- IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α (2014) (209)
- PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. (2016) (209)
- Brown and Beige Fat: Molecular Parts of a Thermogenic Machine (2015) (207)
- Modulation of Estrogen Receptor-α Transcriptional Activity by the Coactivator PGC-1* (2000) (204)
- A fundamental system of cellular energy homeostasis regulated by PGC-1α (2007) (203)
- Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. (2007) (199)
- Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. (2006) (199)
- PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. (2007) (191)
- Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. (2006) (190)
- Control of specific protein biosynthesis during the adipose conversion of 3T3 cells. (1980) (183)
- Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms. (1992) (183)
- Adipocyte differentiation: a transcriptional regulatory cascade. (1996) (179)
- Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. (2007) (176)
- The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria (2016) (174)
- Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. (2002) (167)
- Loss-of-function mutations in PPAR gamma associated with human colon cancer. (1999) (166)
- Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. (2012) (163)
- A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation (1989) (163)
- The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. (2005) (156)
- Posttranscriptional Control of Adipocyte Differentiation through Activation of Phosphoinositide 3-Kinase* (1998) (156)
- A Phase II Study of Troglitazone, an Activator of the PPARγ Receptor, in Patients with Chemotherapy‐Resistant Metastatic Colorectal Cancer (2002) (143)
- Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression (1992) (142)
- TNF-α and insulin resistance: Summary and future prospects (1998) (141)
- PPARγ in Monocytes: Less Pain, Any Gain? (1998) (141)
- Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. (1994) (139)
- Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. (1993) (139)
- Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. (2017) (139)
- Cell biology of fat storage (2016) (136)
- Targeted Elimination of Peroxisome Proliferator-Activated Receptor γ in β Cells Leads to Abnormalities in Islet Mass without Compromising Glucose Homeostasis (2003) (134)
- Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: Age, diet, and PPARγ effects (2014) (133)
- A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue. (1985) (132)
- Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. (1991) (132)
- H+ Transport is an Integral Function of the Mitochondrial ADP/ATP Carrier (2019) (131)
- PGC-1beta in the regulation of hepatic glucose and energy metabolism. (2003) (131)
- Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression (2009) (131)
- Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate‐specific antigen level after radical prostatectomy and/or radiation therapy (2004) (130)
- NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection (2010) (130)
- Suppression of β Cell Energy Metabolism and Insulin Release by PGC-1α (2003) (129)
- Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control (1985) (127)
- Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene. (1992) (127)
- PPARγ and the control of adipogenesis (1997) (126)
- Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. (2017) (125)
- Turnover of tubulin and the N site GTP in chinese hamster ovary cells (1977) (124)
- PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types (2010) (123)
- Null Mutation of c-fos Impairs Structural and Functional Plasticities in the Kindling Model of Epilepsy (1996) (123)
- PPARδ Agonism Activates Fatty Acid Oxidation via PGC-1α but Does Not Increase Mitochondrial Gene Expression and Function (2009) (122)
- Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity. (1997) (121)
- Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins. (1996) (121)
- An adipogenic cofactor bound by the differentiation domain of PPARγ (1999) (120)
- Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. (2002) (119)
- PPAR gamma and the molecular control of adipogenesis. (1997) (119)
- A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. (2016) (118)
- UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction (2017) (117)
- TNF-alpha and insulin resistance: summary and future prospects. (1998) (116)
- CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling (2020) (116)
- Synergy between PPARγ Ligands and Platinum-Based Drugs in Cancer (2007) (114)
- Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. (2018) (114)
- Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1* (1998) (113)
- A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis. (1998) (113)
- 1-Butyryl-Glycerol: A novel angiogenesis factor secreted by differentiating adipocytes (1990) (112)
- PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis (2009) (111)
- Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. (2011) (108)
- Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes. (1982) (107)
- Innervation of Thermogenic Adipose Tissue via a Calsyntenin-3β/S100b Axis (2019) (106)
- Hic-5 regulates an epithelial program mediated by PPARgamma. (2005) (105)
- Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells (1979) (104)
- Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. (2006) (100)
- Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity. (1997) (100)
- Peroxisome proliferator-activated receptor gamma and the control of adipogenesis. (1997) (99)
- Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF. (1995) (97)
- Multiple sites for the initiation of microtubule assembly in mammalian cells (1979) (96)
- Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands (2010) (95)
- A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling (2012) (94)
- Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. (1989) (94)
- Adipose Expression of the Phosphoenolpyruvate Carboxykinase Promoter Requires Peroxisome Proliferator-activated Receptor γ and 9-cis-Retinoic Acid Receptor Binding to an Adipocyte-specific Enhancer in Vivo* (1999) (91)
- Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons (2010) (89)
- Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. (2015) (87)
- Protooncogene c-fos as a transcription factor. (1990) (87)
- Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity (2019) (87)
- Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. (2003) (86)
- Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation (2008) (84)
- Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. (2017) (84)
- G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy (2014) (84)
- Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor. (1986) (83)
- Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. (2003) (82)
- Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans (2019) (82)
- γδT cells and adipocyte IL-17RC control fat innervation and thermogenesis (2019) (80)
- Perspectives in Diabetes Tumor Necrosis Factor a: A Key Component of the Obesity-Diabetes Link (1994) (79)
- Behavioral assessment of c-fos mutant mice (1994) (78)
- Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA. (1990) (78)
- Banting Lecture 2012 (2013) (77)
- Cyclic AMP-mediated control of lipogenic enzyme synthesis during adipose differentiation of 3T3 cells (1981) (77)
- Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression. (1994) (77)
- The Protein Level of PGC-1α, a Key Metabolic Regulator, Is Controlled by NADH-NQO1 (2013) (76)
- Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters (1997) (75)
- Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling (2018) (75)
- Identification of a fat cell enhancer: Analysis of requirements for adipose tissue‐specific gene expression (1992) (74)
- Normal peripheral T-cell function in c-Fos-deficient mice. (1994) (74)
- A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. (2002) (72)
- Time Window Expansion for HDX Analysis of an Intrinsically Disordered Protein (2013) (71)
- Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism (2020) (71)
- Regression of Drug-Resistant Lung Cancer by the Combination of Rosiglitazone and Carboplatin (2008) (71)
- Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-\(\gamma\) Coactivator-1\(\alpha\) Expression (2009) (71)
- Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms (2017) (71)
- Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments. (1997) (70)
- PPAR gamma and the control of adipogenesis. (1997) (69)
- Partnership of PGC-1α and HNF4α in the Regulation of Lipoprotein Metabolism* (2006) (69)
- Peroxisome proliferator–activated receptor γ ligands and atherosclerosis: ending the heartache (2000) (68)
- Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes. (1980) (68)
- Transdifferentiation of myoblasts by the adipogenic transcription factors PPARy and C / EBPa ! (2005) (67)
- Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation (2016) (65)
- Synergy between PPARgamma ligands and platinum-based drugs in cancer. (2007) (63)
- Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. (1979) (63)
- Growth and differentiation of embryonic stem cells that lack an intact c-fos gene. (1992) (63)
- Modulation of PGC-1 Coactivator Pathways in Brown Fat Differentiation through LRP130* (2008) (60)
- Author Correction: Exercise hormone irisin is a critical regulator of cognitive function (2021) (59)
- Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex (2011) (58)
- CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury. (2016) (58)
- The circadian system of c-fos deficient mice (1996) (57)
- Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity (2017) (56)
- Evidence of an association between genetic variation of the coactivator PGC-1β and obesity (2005) (56)
- Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation. (1987) (53)
- A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size (2012) (53)
- Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation. (1992) (52)
- Creatine kinase B controls futile creatine cycling in thermogenic fat (2021) (52)
- Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes. (1989) (52)
- A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis* (2008) (52)
- Transcriptional control of energy homeostasis through the PGC1 coactivators. (2007) (52)
- Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo (2020) (51)
- Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1α) expression in the murine brain (2003) (51)
- Regulation of adipogenesis and energy balance by PPARgamma and PGC-1. (2000) (49)
- Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. (2006) (49)
- Regulation of alternative pathway activation and C3a production by adipose cells. (1996) (46)
- Muscle-specific expression of PPAR (cid:1) coactivator-1 (cid:2) improves exercise performance and increases peak oxygen uptake (2008) (46)
- Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming (2014) (45)
- Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. (2019) (43)
- PPARgamma in monocytes: less pain, any gain? (1998) (42)
- Chemical Probes That Differentially Modulate Peroxisome Proliferator-activated Receptor α and BLTR, Nuclear and Cell Surface Receptors for Leukotriene B4 * (1999) (41)
- CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER. (2016) (40)
- Obesity: Towards a molecular approach (1990) (40)
- correction: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 (2001) (39)
- DEF-1, a Novel Src SH3 Binding Protein That Promotes Adipogenesis in Fibroblastic Cell Lines (1999) (39)
- Irisin ERKs the Fat (2014) (39)
- Erratum: Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (Cell (2018) 175(7) (1756–1768.e17), (S0092867418313345), (10.1016/j.cell.2018.10.025)) (2019) (39)
- Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice. (1989) (39)
- Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy (2018) (39)
- Heparin potentiation of 3T3‐adipocyte stimulated angiogenesis: Mechanisms of action on endothelial cells (1986) (38)
- The future of brown adipose tissues in the treatment of type 2 diabetes (2015) (38)
- DNA‐binding activity of jun is increased through its interaction with Fos (1990) (38)
- PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. (2011) (37)
- Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine (2021) (36)
- Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception (2018) (35)
- Erratum: Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity (Cell Metabolism (2017) 26(4) (660–671.e3) (S1550413117304941)(10.1016/j.cmet.2017.08.009)) (2017) (35)
- Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function. (1988) (34)
- Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3 (2020) (34)
- Cachexia and Brown Fat: A Burning Issue in Cancer. (2016) (34)
- An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. (2019) (34)
- The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1 a / ATF 6 a Complex (2011) (33)
- fos protooncogene and the regulation of gene expression in adipocyte differentiation (1988) (32)
- Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine. (1990) (31)
- Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. (2021) (31)
- Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache. (2000) (28)
- Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. (2005) (27)
- Obesity-linked regulation of the adipsin gene promoter in transgenic mice. (1989) (26)
- Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity. (1991) (26)
- Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity (2020) (25)
- PPARγ ligands: Taking Ppart in chemoprevention (2003) (24)
- Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction. (2016) (23)
- "The adipocyte: a multifunctional cell". (2006) (22)
- Identifying novel transcriptional components controlling energy metabolism. (2011) (21)
- Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha. (1997) (21)
- Adipsin: regulation and dysregulation in obesity and other metabolic states. (1989) (21)
- c‐Fos Deficiency Inhibits Induction of mRNA for Some, but Not All, Neurotransmitter Biosynthetic Enzymes by Immobilization Stress (1998) (21)
- Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol. (1993) (19)
- The molecular link between obesity and diabetes (1996) (19)
- Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes. (1993) (19)
- A direct role for c-fos in AP-1-dependent gene transcription. (1990) (18)
- Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice. (1994) (18)
- Do Adipocytes Emerge from Mural Progenitors? (2017) (18)
- Regulation of gene expression of catecholamine biosynthetic enzymes by stress. (1998) (18)
- Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration. (2018) (17)
- Erratum: Increased muscle pgc-1αexpression protects from sarcopenia and metabolic disease during aging (Proceedings of the National Academy of Sciences of the United States of America (2009) 106 (20405-20410)) (2014) (17)
- Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D (1993) (16)
- Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (2019) (16)
- Retraction Notice to: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype. (2016) (16)
- Adrenergic pathways involved in regulation of uncoupling protein gene expression (1994) (15)
- Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression (1992) (14)
- Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. (2021) (13)
- Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentia (2006) (12)
- Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats. (1990) (11)
- A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity. (2020) (11)
- Exercise hormone irisin is a critical regulator of cognitive function (2021) (10)
- Tumor necrosis factor-α as a mediator of the insulin resistance of obesity (1999) (10)
- Confounding issues in the ‘humanized’ BAT of mice (2020) (10)
- Hypomorphic Mutation in PGC1 β causes mitochondrial dysfunction and liver insulin resistance (2008) (9)
- Corrigendum: Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments (Nucleic Acids Research (1997) 25 (2543-2545)) (1997) (9)
- PPARgamma ligands: taking Ppart in chemoprevention. (2003) (9)
- Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation (2013) (9)
- SnapShot: Regulation and biology of PGC-1α (2022) (9)
- No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians (2021) (9)
- Response to Comment on Wu and Spiegelman. Irisin ERKs the Fat. Diabetes 2014;63:381−383 (2014) (8)
- The Role of FNDC5/Irisin in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain -- Hormones, Metabolism and the Benefits of Exercise (2017) (8)
- Erratum: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 (Nature (2001) 413 (179-183)) (2001) (8)
- Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 (2016) (7)
- Role and Regulation of PPARy During Adipogenesis (1999) (7)
- Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin (2022) (6)
- For a pragmatic approach to exercise studies. (2010) (6)
- Hormones, Metabolism and the Benefits of Exercise (2017) (6)
- Rapid Publication Nutritional and Insulin Regulation of Fatty Acid Synthetase and Leptin Gene Expression through ADD 1 / SREBP 1 (1997) (6)
- PGC‐1 Coactivators and the Control of Energy Homeostasis (2006) (5)
- c-fos is not essential for v-abl-induced lymphomagenesis. (1995) (5)
- Novel Insights into Adipose Cell Functions (2010) (5)
- PGC1α and Exercise Adaptations in Zebrafish (2018) (4)
- Chemical probes that differentially modulate PPARα and BLTR, nuclear and cell surface receptors for leukotriene B4 (1999) (4)
- Measurement of Futile Creatine Cycling Using Respirometry. (2022) (3)
- Boström et al. reply (2012) (3)
- The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice. (2016) (3)
- Cell Metabolism: Why, and why now? (2005) (3)
- Supplemental Information A Secreted Slit 2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function (2016) (3)
- Commentaries on Viewpoint: Gold standards for scientists who are conducting animal-based exercise studies [4] (2010) (3)
- Transcriptional Regulation of Brown and White Adipogenesis (2010) (3)
- Evidence of an association between genetic variation of the coactivator PGC-1 b and obesity (2005) (3)
- Identification of novel genes involved in adipose differentiation by differential display. (1997) (3)
- Architecture of the outbred brown fat proteome defines regulators of metabolic physiology (2022) (2)
- PGC-1α and Metabolic Control in Skeletal and Cardiac Muscle (2008) (2)
- Skeletal Muscle microRNAs: Roles in Differentiation, Disease and Exercise -- Hormones, Metabolism and the Benefits of Exercise (2017) (2)
- Obesity, towards a molecular approach : proceedings of a UCLA Symposium held at Keystone, Colorado, April 17-23, 1989 (1990) (2)
- Transgenic Mouse Models of Disease: Altering Adipose Tissue Function in Vivo (1995) (2)
- Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle -- Hormones, Metabolism and the Benefits of Exercise (2017) (2)
- Cell differentiationEditorial overview (1999) (2)
- Irisin and the therapeutic benefits of exercise (2012) (2)
- Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. (2023) (2)
- Involvement of fos as a trans-acting factor in adipogenic gene expression. (1988) (2)
- Author response: Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo (2020) (2)
- Transcriptional Modulator of Mesenchymal Stem Cell Differentiation (2005) (2)
- Cell differentiation. Editorial overview (1990) (2)
- Fat cells directly sense temperature to activate (2013) (1)
- Thermoneutrality induces skeletal muscle myopathy via brown adipose tissue in an IRF4- and myostatin-dependent manner (2018) (1)
- Mechanism of futile creatine cycling in thermogenesis. (2020) (1)
- Adipogenesis and Obesity: Review Rounding Out the Big Picture (1996) (1)
- Author Correction: Exercise hormone irisin is a critical regulator of cognitive function (2021) (1)
- Human Brown Adipose Tissue Plasticity: Hormonal and Environmental Manipulation -- Hormones, Metabolism and the Benefits of Exercise (2017) (1)
- Modulator of Mesenchymal Stem Cell Differentiation (2005) (1)
- A novel PGC‐1á isoform induced by resistance training regulates skeletal muscle hypertrophy (2013) (1)
- Good Fats and Thin Bats The Fats of Life By Caroline Pond Cambridge: Cambridge (1998). 344 pp. $59.95 (1999) (1)
- [TNF-alpha: molecular tie between obesity and insulin resistance]. (1997) (1)
- Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism (2020) (1)
- Tryptophan-Kynurenine Metabolites in Exercise and Mental Health -- Hormones, Metabolism and the Benefits of Exercise (2017) (1)
- 66 PPARγ and the molecular regulation of adipocyte differentiation (1997) (1)
- Activation of the alternative complement pathway in factor D-deficient mice (2000) (1)
- The perils of putting career before all else (2002) (1)
- A conversation with Bruce Spiegelman. Interviewed by Ushma Neill. (2013) (1)
- Abstract 13238: C/ebpb Controls Cardiac Growth During Exercise (2010) (0)
- Figure 11, Effect of Probe ML244 on expression of genes involved with osteoblast differentiation (2013) (0)
- Abstract B062: Investigate the role of T lymphocytes in the regulation of energy expenditure and obesity (2019) (0)
- Role of Mitochondrial TNAP in Thermogenesis and Obesity (2022) (0)
- "Brown and Beige Fat: Basic Biology and Potential New Therapeutics" (2013) (0)
- Table 1, PubChem BioAssays (2013) (0)
- Developmentally Regulated mRNAs Analysis of Transcriptional Control in 3T3-Adipocytes: (2002) (0)
- Figure 7, [a, Chemical structures of ML244...]. (2013) (0)
- Plasma Steroids and Cardiorespiratory Fitness Response to Regular Exercise -- Hormones, Metabolism and the Benefits of Exercise (2017) (0)
- Detection and Quantitatio n of Circulating Human Irisin by Tandem Mass Spectrometry Graphical (0)
- Figure 16, Quantitative PCR (qPCR) results were used to quantify enrichment of PPARγ or SRC1 at the aP2 promoter using chromatin immunoprecipitation (ChIP) assay (2013) (0)
- 35 Increased mitochondrial biogenesis as therapy for mitochondrial myopathies (2010) (0)
- Cytoskeleton reorganization is required for changes in gene expression during pre adipocyte differentiation (1982) (0)
- G protein coupled receptor 56 is a target gene of the PGC‐1α4 isoform and regulates overload‐induced muscle hypertrophy (1163.15) (2014) (0)
- Cardiovascular biology: Good cholesterol gets even better (2015) (0)
- Age-related changes associated with the induction of o-pyrocatechuic acid carboxylase in Aspergillus ornatus. (1975) (0)
- O-47: Mechanisms of TNF-α induced insulin resistance (2009) (0)
- Figure 12, Selectivity screening of ML244 against a collection of > 50 mammalian nuclear receptors (2013) (0)
- Figure 14, Overlay of differential HDX data onto the docking model of 2hfp bound to ML244 (2013) (0)
- Methods and pharmaceutical compositions for inhibiting tumor growth (1997) (0)
- Cell differentiation. (1991) (0)
- PPAR (cid:103) 2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene (1994) (0)
- Molecular Identity and Regulatory Mechanisms of the Mitochondrial Uncoupling Protein of Regular Somatic Tissues (2018) (0)
- Age-related changes associated with the induction of o-pyrocatechuic acid carboxylyase in Aspergillus ornatus (1975) (0)
- A Direct RoleforC/EBPandtheAP-I-Binding SiteinGene Expression Linked toAdipocyte Differentiation (1989) (0)
- Figure 13, Differential Hydrogen-Deuterium Exchange (HDX) data for rosiglitazone, MRL24, probe ML244 and SR1848 (2013) (0)
- Regulation of adipogenesis and energy balance by the PPARγ system. (2000) (0)
- γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis (2020) (0)
- Author Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis (2021) (0)
- Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis (2019) (0)
- Appendix 2. Draft Proposal for a Harvard Vaccine Institute (0)
- Table 3, In vitro profile of SR-9034 Analogs (2013) (0)
- Figure 6, Cartoon showing the critical path of the High Throughput Screening (HTS) campaign hit selection process and numeric assay cutoffs (2013) (0)
- Molecular Identity and Regulatory Mechanisms of the Mitochondrial Uncoupling Protein of Non-Adipose Tissues (2020) (0)
- Cell Differentiation. (2007) (0)
- PGC‐1α is required for exercise‐induced mitochondrial biogenesis, but not fiber type transformation, in skeletal muscle (2008) (0)
- Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis (2019) (0)
- Society for Endocrinology Transatlantic Medal Lecture (2007) (0)
- RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1α (2023) (0)
- Immunology: How malaria raises cancer risk (2015) (0)
- Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity (2019) (0)
- PGC-1, a novel PPAR-gamma coactivator OFF brown adipose tissue (1998) (0)
- Irisin Mediates Effects on Bone via αV Integrin Receptors (2019) (0)
- Table 4, Structural Comparison of Probe ML244 (2013) (0)
- Cell Metabolism PRDM 16 Regulates Brown Fat Cell Fate tumors (0)
- FROM INTERSCAPULAR BROWN ADIPOSE TISSUE AND WHITE ADIPOSE Mitochondrial Turnover: A PHENOTYPE DISTINGUISHING BROWN ADIPOCYTES (2015) (0)
- Figure 10, In vitro functional analysis of ML244 (2013) (0)
- Chair's Introduction (2007) (0)
- Figure 17, ML244 antagonizes the transcriptional agonism of rosiglitazone (2013) (0)
- Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans (2019) (0)
- Sending the Signal: Muscle Glycogen Availability as a Regulator of Training Adaptation -- Hormones, Metabolism and the Benefits of Exercise (2017) (0)
- Tursiops truncatus Whistle Matching in Wild Bottlenose Dolphins (2008) (0)
- New pgc-1 isoforms and their uses (2002) (0)
- "copsnbmhmvdptfipnfptubtjt Jotlfmfubmnvtdmfmtqfdjgjd1($α Lopdlpvunjdfsfwfbmttlfmfubm Nvtdmfmqbodsfbujdβdfmmdspttubml (2007) (0)
- Figure 8, Dose response curves of ML244 ( Left panel) and SR1824 (Right panel) as compared to rosiglitazone in the competitive Lanthascreen assay (n=3) (2013) (0)
- Cell Metabolism Exercise-Induced PGC-1 a / FNDC 5 / BDNF Pathway (2013) (0)
- Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science (2012) (0)
- Irisin directly stimulates osteoclastogenesis and bone resorption (2020) (0)
- Figure 4, [Whole-body weight (left) and fat...]. (2013) (0)
- Final discussion: Nutrition, ageing and lipotoxicity (2007) (0)
- Figure 5, Stability of ML244 (2013) (0)
- Regulation of gene expression during the differentiation of 3T3-adipocytes. (1986) (0)
- Antagonistic regulation of Drosophila mitochondrial uncoupling protein UCP4b by cold and BMP signaling (2022) (0)
- studieswho are conducting animal-based exercise Commentaries on Viewpoint: Gold standards for (2015) (0)
- CKB controls futile creatine cycling in thermogenic fat (2021) (0)
- Peroxisome Proliferator-Activated Receptor- (cid:1) Coactivator 1 (cid:2) (PGC-1 (cid:2) ): Transcriptional Coactivator and Metabolic Regulator (2003) (0)
- Figure 9, SAR of Lead PPARγ partial agonist SR-9034 (2013) (0)
- Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis (2019) (0)
- gene programming and controls diabetic γ Thrap 3 docks on phosphoserine 273 of PPAR (2014) (0)
- [Table, Structure verification with 1H NMR, 13CNMR, and LCMS results]. (2013) (0)
- Figure 15, Docking model of ML244 to PDB structure 2hfp (2013) (0)
- Figure 1, [a and b, in vitro...]. (2013) (0)
- Irisin Stimulates Osteoclast Differentiation and Function (2020) (0)
- Editorial Board (2010) (0)
- Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science (2012) (0)
- Mechanism of obesity suppression by adipose tissue creatine energetics (2018) (0)
- Figure 3, Fasting body weight, blood glucose and insulin levels prior to glucose-tolerance tests (GTT) in ob/ob mice treated with vehicle, rosiglitazone or ML244 (n=8) (2013) (0)
- REPTOR/CREBRF encode key regulators of muscle energy metabolism (2021) (0)
- QnAs with Bruce M. Spiegelman. (2011) (0)
- ADIPSIN IS AN ADIPOCYTOKINE DYSREGULATED IN OBESITY/METABOLIC SYNDROME THAT SUSTAINS CARDIOVASCULAR HEALTH (2014) (0)
- Transcriptional Control of Brown Adipogenesis and Energy Homeostasis (2010) (0)
- Figure 2, Anti-diabetic activity of ML244 in high-fat diet (HFD) mice (2013) (0)
- Table 2, Binding affinity as determined in a competitive Lanthascreen assay (PubChem AID 504943) and transcriptional activity (PubChem AID 504939) of chemical derivatives of the Lamotte et al prior art compound 7b from the literature (2013) (0)
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