Bryan R Williams

Q: What Schools Are Affiliated With Bryan R Williams

Bryan R Williams is affiliated with the following schools: Stanford University, Case Western Reserve University, University of Toronto, University of Washington, Duke University, Monash University, Washington University in St. Louis, University of California, Berkeley, Yale University

Bryan R Williams's AcademicInfluence.com Rankings

Bryan R Williams

Computer Science

#3992

World Rank

#4198

Historical Rank

Computational Linguistics

#302

World Rank

#307

Historical Rank

Machine Learning

#655

World Rank

#665

Historical Rank

Artificial Intelligence

#857

World Rank

#873

Historical Rank

computer-science Degrees

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Computer Science

Bryan R Williams's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Bryan R Williams's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

How cells respond to interferons. (1998) (4172)
Interferon-inducible antiviral effectors (2008) (1936)
Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays (1998) (1679)
Activation of the interferon system by short-interfering RNAs (2003) (1494)
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon (1990) (985)
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. (1998) (941)
Functional classification of interferon‐stimulated genes identified using microarrays (2001) (899)
PKR; a sentinel kinase for cellular stress (1999) (890)
Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis (2003) (811)
TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages (2002) (685)
Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. (1998) (518)
Signal Integration via PKR (2001) (449)
ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins (2001) (432)
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons (1999) (401)
JNK2 and IKKbeta are required for activating the innate response to viral infection. (1999) (399)
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells (2006) (392)
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation (2011) (389)
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF‐1 and NF‐κB (1997) (368)
Activation of the mammalian immune system by siRNAs (2005) (362)
Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts (1978) (358)
TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. (2002) (358)
Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR* (2003) (337)
ARED 3.0: the large and diverse AU-rich transcriptome (2005) (329)
NF-κB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-κB-Inducing Kinase and IκB Kinase (2000) (328)
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1 (2011) (322)
p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Signaling of mRNA Stability of AU-Rich Element-Containing Transcripts (2003) (321)
ATF3 transcription factor and its emerging roles in immunity and cancer (2009) (315)
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin (2000) (295)
Regulation of c‐myc expression by IFN‐γ through Stat1‐dependent and ‐independent pathways (2000) (290)
Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways (2003) (287)
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways. (1999) (257)
PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons (2006) (252)
Viral apoptosis is induced by IRF‐3‐mediated activation of Bax (2010) (238)
The response of mammalian cells to double-stranded RNA. (2007) (228)
Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth (1992) (226)
Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells (1979) (220)
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. (2004) (214)
ISG20, a New Interferon-induced RNase Specific for Single-stranded RNA, Defines an Alternative Antiviral Pathway against RNA Genomic Viruses* (2003) (205)
Negative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-31 (2007) (203)
Potential Alu Function: Regulation of the Activity of Double-Stranded RNA-Activated Kinase PKR (1998) (198)
High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3 (2013) (193)
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. (1997) (192)
Structure and function of the protein kinase R. (2007) (190)
Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system (1991) (189)
Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction* (1998) (188)
ARED 2.0: an update of AU-rich element mRNA database (2003) (187)
Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus (2002) (186)
Synergistic Activation of Innate Immunity by Double-Stranded RNA and CpG DNA Promotes Enhanced Antitumor Activity (2004) (182)
Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation. (1997) (180)
Transcriptional regulation of interferon-stimulated genes. (1991) (174)
Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. (1990) (162)
A miR-19 regulon that controls NF-κB signaling (2012) (162)
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR. (1995) (158)
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. (2000) (156)
Inhibition of protein synthesis by 2′–5′ linked adenine oligonucleotides in intact cells (1978) (155)
Early immune response in healthy and immunocompromised subjects with primary varicella-zoster virus infection. (1986) (154)
NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. (2000) (153)
RNA interference in biology and disease. (2005) (149)
Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues. (2010) (147)
TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages1 (2008) (146)
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. (1994) (146)
Signal transduction by interferon-alpha through arachidonic acid metabolism. (1991) (144)
A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. (2006) (144)
Signal transduction in the interferon system. (1998) (141)
Heterogeneity in Control of mRNA Stability by AU-rich Elements* (2003) (136)
Constitutive expression of a 2',5'-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression. (1989) (135)
Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts. (1990) (135)
Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses. (2003) (129)
Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. (2003) (125)
The B56α Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR (2000) (124)
PKR-Dependent and -Independent Mechanisms Are Involved in Translational Shutoff during Sindbis Virus Infection (2004) (123)
Functional Replacement of the Carboxy-Terminal Two-Thirds of the Influenza A Virus NS1 Protein with Short Heterologous Dimerization Domains (2002) (121)
Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis. (1993) (120)
Fine‐tuning of the innate immune response by microRNAs (2007) (119)
Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice (2002) (119)
Synthesis and breakdown of pppA2'p5'A2'p5'A and transient inhibiton of protein synthesis in extracts from interferon-treated and control cells. (1978) (118)
Analysis of Genes Induced by Sendai Virus Infection of Mutant Cell Lines Reveals Essential Roles of Interferon Regulatory Factor 3, NF-κB, and Interferon but Not Toll-Like Receptor 3 (2005) (114)
Inherited WT1 mutation in Denys-Drash syndrome. (1992) (114)
ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton. (2013) (113)
β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. (2012) (111)
Novel Growth and Death Related Interferon-Stimulated Genes (ISGs) in Melanoma: Greater Potency of IFN-β Compared with IFN-α2 (2003) (110)
Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon (2004) (108)
Fine tuning type I interferon responses. (2013) (106)
Protein Kinase R (PKR) Interacts with and Activates Mitogen-activated Protein Kinase Kinase 6 (MKK6) in Response to Double-stranded RNA Stimulation* (2004) (105)
Interferons induce an antiviral state in human pancreatic islet cells. (2007) (103)
Roles of globotriosyl- and galabiosylceramide in verotoxin binding and high affinity interferon receptor. (1987) (102)
Molecular characterization of cytogenetic alterations associated with the Beckwith-Wiedemann syndrome (BWS) phenotype refines the localization and suggests the gene for BWS is imprinted. (1993) (101)
Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities (2006) (99)
Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene. (1991) (96)
Mutations of the p53 tumor suppressor gene occur infrequently in Wilms' tumor. (1994) (94)
Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling (*) (1995) (93)
The role of the dsRNA-activated kinase, PKR, in signal transduction (1995) (92)
Activation of a nuclease by pppA2′p5′ A2′p5′ A in intact cells (1979) (91)
"Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60. (2006) (88)
Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity (2009) (87)
HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms. (2000) (86)
The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10* (2013) (85)
Two distinct tumor suppressor loci within chromosome 11p15 implicated in breast cancer progression and metastasis. (1998) (83)
The Promyelocytic Leukemia Zinc Finger Protein: Two Decades of Molecular Oncology (2012) (83)
An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A (2009) (82)
Developmental expression of the endogenous TIMP gene and a TIMP-lacZ fusion gene in transgenic mice. (1990) (80)
Human 2‐5A synthetase: characterization of a novel cDNA and corresponding gene structure. (1985) (79)
Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2. (2003) (79)
Homozygous somatic Wt1 point mutations in sporadic unilateral Wilms tumor. (1993) (79)
P53, bcl-2, and Bax expression in renal cell carcinoma. (1998) (77)
Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells. (1993) (76)
Cell cycle regulation of the double stranded RNA activated protein kinase, PKR (1999) (76)
Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-α (1994) (74)
Effect of deficiency of the double-stranded RNA-dependent protein kinase, PKR, on antiviral resistance in the presence or absence of ribonuclease L: HSV-1 replication is particularly sensitive to deficiency of the major IFN-mediated enzymes. (2000) (74)
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L. (2006) (73)
Distinct roles of protein kinase R and toll‐like receptor 3 in the activation of astrocytes by viral stimuli (2007) (73)
Involvement of the Interferon-Regulated Antiviral Proteins PKR and RNase L in Reovirus-Induced Shutoff of Cellular Translation (2005) (73)
Differential Effect of Murine Alpha/Beta Interferon Transgenes on Antagonization of Herpes Simplex Virus Type 1 Replication (2002) (73)
Light controllable siRNAs regulate gene suppression and phenotypes in cells. (2006) (71)
Regulation of interferon receptor expression in human blood lymphocytes in vitro and during interferon therapy. (1986) (70)
Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma. (1995) (69)
Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus‐induced gene in the mouse. (1987) (69)
Different modes of interaction by TIAR and HuR with target RNA and DNA (2011) (69)
Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector. (2007) (69)
Human Immunodeficiency Virus-1/Surface Glycoprotein 120 Induces Apoptosis through RNA-Activated Protein Kinase Signaling in Neurons (2007) (67)
Down-Regulation of p53 by Double-Stranded RNA Modulates the Antiviral Response (2005) (67)
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs* (2015) (64)
The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain. (2008) (64)
Rational design of immunostimulatory siRNAs. (2010) (63)
Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice (2007) (63)
A gene expression signature for relapse of primary wilms tumors. (2005) (63)
Expression of WT1 protein in fetal kidneys and Wilms tumors. (1994) (62)
Genetic modulation of TLR8 response following bacterial phagocytosis (2010) (61)
The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease (2013) (61)
Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation. (2004) (61)
The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture. (2003) (59)
The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF (2015) (58)
Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells* (1999) (58)
The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors. (1999) (57)
A non‐canonical function of Ezh2 preserves immune homeostasis (2017) (57)
RNase L Mediates Transient Control of the Interferon Response through Modulation of the Double-stranded RNA-dependent Protein Kinase PKR* (2003) (56)
Antisense transcripts and protein binding motifs within the Wilms tumour (WT1) locus. (1994) (55)
PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon. (1993) (55)
Derivation and characterization of a Wilms' tumour cell line, WiT 49 (2003) (54)
Interferon-stimulated genes and their protein products: what and how? (2011) (54)
X chromosome inactivation of the human TIMP gene. (1990) (52)
Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro* (2006) (52)
BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs (2015) (51)
Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells. (2008) (50)
Novel interferon‐β‐induced gene expression in peripheral blood cells (2007) (49)
The Wilms Tumor Suppressor-1 Target Gene Podocalyxin Is Transcriptionally Repressed by p53* (2004) (49)
A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L (2005) (49)
The respective roles of the protein kinase and pppA2' p5' A2' p5 A-activated endonuclease in the inhibition of protein synthesis by double stranded RNA in rabbit reticulocyte lysates. (1979) (49)
Detection of foreign RNA: Implications for RNAi (2005) (49)
Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia (2005) (48)
Characterization and regulation of alpha-interferon receptor expression in interferon-sensitive and -resistant human lymphoblastoid cells. (1984) (48)
The 2–5A (pppA2′ p5′ A2′ p5′ A) system in interferon-treated and control cells (1980) (48)
Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients (2017) (48)
Role of PKR and Type I IFNs in Viral Control during Primary and Secondary Infection (2010) (47)
Analysis of WT1 in granulosa cell and other sex cord-stromal tumors. (1993) (47)
The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli. (2008) (47)
Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation* (2000) (46)
Integrin-linked Kinase Modulates Lipopolysaccharide- and Helicobacter pylori-induced Nuclear Factor κB-activated Tumor Necrosis Factor-α Production via Regulation of p65 Serine 536 Phosphorylation* (2014) (46)
Differential binding of human interferon-α subtypes to receptors on lymphoblastoid cells (1983) (45)
Limited role of N-terminal phosphoserine residues in the activation of transcription by p53 (2004) (44)
Inhibition of Double-Stranded RNA- and Tumor Necrosis Factor Alpha-Mediated Apoptosis by Tetratricopeptide Repeat Protein and Cochaperone P58IPK (1999) (44)
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. (2012) (43)
Cystic fibrosis and normal human airway epithelial cell response to influenza a viral infection. (2006) (43)
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages (2021) (42)
Cellular retinoic acid-binding protein II is a direct transcriptional target of MycN in neuroblastoma. (2006) (42)
Alphavirus Minus-Strand Synthesis and Persistence in Mouse Embryo Fibroblasts Derived from Mice Lacking RNase L and Protein Kinase R (2003) (41)
TLR2 and TLR4 agonists stimulate unique repertoires of host resistance genes in murine macrophages: interferon-beta-dependent signaling in TLR4-mediated responses. (2003) (41)
Reduced expression of autotaxin predicts survival in uveal melanoma (2007) (41)
Enhancement by retinoic acid and dibutyryl cyclic adenosine 3':5'-monophosphate of the differentiation and gene expression of human neuroblastoma cells induced by interferon. (1991) (41)
Protein kinase R and the inflammasome. (2014) (40)
Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity (2015) (40)
Modulation of human interferon-alpha receptor expression by human interferon-gamma. (1984) (40)
The murine 2-5A synthetase locus: three distinct transcripts from two linked genes. (1991) (40)
ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types (2017) (39)
Expressed gene clusters associated with cellular sensitivity and resistance towards anti-viral and anti-proliferative actions of interferon. (2004) (39)
Downregulation of interferon alpha but not gamma receptor expression in vivo in the acquired immunodeficiency syndrome. (1988) (39)
Coordinate expression of Wilms' tumor genes correlates with Wilms' tumor phenotypes. (1992) (38)
Expression of interferon-induced genes in different tissues of mice (1988) (38)
Protein Kinase R-dependent Regulation of Interleukin-10 in Response to Double-stranded RNA* (2008) (37)
Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors (2014) (36)
Interacting pathways of interferon signaling. (1997) (36)
Molecular cloning of partial cDNA copies of two distinct mouse IFN-β mRNAs (1982) (36)
The kinase activity of PKR represses inflammasome activity (2016) (35)
Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferon. (1998) (35)
Presence of transcription regulatory elements within an intron of the virus-inducible murine TIMP gene (1988) (34)
Salicylates Trigger Protein Synthesis Inhibition in a Protein Kinase R-like Endoplasmic Reticulum Kinase-dependent Manner* (2007) (34)
Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing. (2012) (34)
Faculty Opinions recommendation of Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta. (2011) (33)
Expression of IFITM1 in chronic myeloid leukemia patients. (2005) (33)
Activation of cGAS-dependent antiviral responses by DNA intercalating agents (2016) (33)
Microsatellite instability at a single locus (D11S988) on chromosome 11p15.5 as a late event in mammary tumorigenesis. (1995) (32)
Elevated levels of interferon-induced 2'-5' oligoadenylate synthetase in generalized persistent lymphadenopathy and the acquired immunodeficiency syndrome. (1985) (32)
Localization of TIMP in cycling mouse hair. (1991) (31)
X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells (2010) (30)
AU-rich transient response transcripts in the human genome: expressed sequence tag clustering and gene discovery approach. (2005) (30)
Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor (1989) (29)
Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses (2020) (28)
Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha. (1994) (28)
Differential expression in clear cell renal cell carcinoma identified by gene expression profiling. (2009) (28)
PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers (2018) (28)
Roles of protein-tyrosine phosphatases in Stat1 alpha-mediated cell signaling. (1995) (28)
Interferon-induced 2-5A synthetase activity in human peripheral blood mononuclear cells after immunization with influenza virus and rubella virus vaccines (1984) (27)
Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly (2013) (27)
Novel interferon-beta-induced gene expression in peripheral blood cells. (2007) (27)
Distinctive Roles for 2′,5′-Oligoadenylate Synthetases and Double-Stranded RNA-Dependent Protein Kinase R in the In Vivo Antiviral Effect of an Adenoviral Vector Expressing Murine IFN-β1 (2004) (27)
Dynamic flexibility of double-stranded RNA activated PKR in solution. (2006) (25)
The role of interferon and tumor necrosis factor in the pathogenesis of AIDS. (1990) (25)
Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8 (2013) (25)
Differential human interferon α receptor expression on proliferating and non‐proliferating cells (1986) (24)
Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication. (2009) (23)
Differential expression of E-cadherin and β catenin in primary and metastatic Wilms’s tumours (2003) (23)
Stability of CXCL-8 and related AU-rich mRNAs in the context of hepatitis C virus replication in vitro. (2006) (23)
Molecular cloning of cDNAs from androgen-independent mRNA species of DBA/2 mouse sub-maxillary glands. (1984) (23)
Regulation of CRABP-II expression by MycN in Wilms tumor. (2008) (23)
Expression of a chemically synthesized human alpha 1 interferon gene. (1982) (22)
Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses (2017) (22)
IL‐10 regulates Aicda expression through miR‐155 (2015) (22)
Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry (2017) (22)
C114 Is a Novel IL-11-inducible Nuclear Double-stranded RNA-binding Protein That Inhibits Protein Kinase R* (2003) (20)
Vascular endothelial growth factor (VEGF) is suppressed in WT1-transfected LNCaP cells. (2006) (20)
Involvement of double-stranded RNA-activated protein kinase in the synergistic activation of nuclear factor-kappaB by tumor necrosis factor-alpha and gamma-interferon in preneuronal cells. (1999) (20)
Targeting specific cell types with silencing RNA. (2005) (20)
The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation (2017) (20)
Regulation of tumor necrosis factor receptor expression by acid-labile interferon-alpha from AIDS sera. (1991) (20)
Signal Transduction and Transcriptional Regulation of Interferon-α–Stimulated Genes (1991) (19)
An Emergence Framework of Carcinogenesis (2017) (19)
Solid phase radioimmunoassay using labelled antibodies: a conceptual framework for designing assays. (1977) (19)
Human PKR transfected into murine cells stimulates expression of genes under control of the HIV1 or HTLV-I LTR. (1995) (18)
A Viral On/Off Switch for Interferon (2003) (18)
RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2 (2005) (18)
Stress responses: Translational control perks up (1999) (17)
Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection. (1996) (17)
Absence of PKR attenuates the anti-HSV-1 activity of an adenoviral vector expressing murine IFN-beta. (2002) (17)
Monitoring innate immune recruitment by siRNAs in mammalian cells. (2010) (17)
Functional differences in the promoters of the interferon-inducible (2'-5')A oligoadenylate synthetase and 6-16 genes in interferon-resistant Daudi cells. (1994) (16)
Tissue-specific regulation of the WT1 locus. (1996) (16)
Recombinant human interferon alpha-2 and juvenile chronic myelogenous leukemia: cell receptor binding, enzymatic induction, and growth suppression in vitro. (1987) (16)
THE ASSAY OF 2-5A SYNTHETASE AS AN INDICATOR OF INTERFERON ACTIVITY AND VIRUS INFECTION IN VIVO11Supported by grants from the Medical Research Council of Canada, the National Cancer Institute of Canada and Physicians Services Incorporated. B.R.G.W. is an MRC Scholar. (1982) (16)
Specific binding of the ETS-domain protein to the interferon-stimulated response element. (1997) (15)
Basal expression of the gene (TIMP) encoding the murine tissue inhibitor of metalloproteinases is mediated through AP1- and CCAAT-binding factors. (1992) (15)
In situ expression of the early growth response gene-1 during murine nephrogenesis. (1995) (15)
Functional annotation of IFN-alpha-stimulated gene expression profiles from sensitive and resistant renal cell carcinoma cell lines. (2006) (15)
A Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity (2021) (14)
Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated region. (1998) (14)
Wilms Tumor: Clinical and Molecular Characterization (1995) (13)
Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis (2017) (13)
(−)‐Epigallocatechin‐3‐gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells (2018) (13)
The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development (2015) (12)
The interaction of interferon-α and -γ: Regulation of (2–5)A synthetase activity (1988) (12)
Assay of (2'-5')-oligo(A) synthesized in vitro and the analysis of naturally occurring (2'-5')-oligo(A) from intact cells. (1981) (12)
Gene Modulatory Effects, Pharmacokinetics, and Clinical Tolerance of Interferon‐α1b: A Second Member of the Interferon‐α Family (2007) (12)
TLR2 and TLR4 agonists stimulate unique repertoires of host resistance genes in murine macrophages: interferon-β-dependent signaling in TLR4-mediated responses (2003) (11)
Dicing with siRNA (2005) (11)
Thrombomodulin RNA is destabilized through its 3'-untranslated element in cells exposed to IFN-gamma. (2003) (11)
Biological Properties of Recombinant Â «-InterfÃ © rons : 40 th Anniversary of the Discovery of Interferons 1 (2006) (11)
Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. (2005) (11)
Activating Transcription Factor 3 Expression as a Marker of Response to the Histone Deacetylase Inhibitor Pracinostat (2016) (11)
Oligoadenylate Synthetase/Protein Kinase R Pathways and αβ TCR+ T Cells Are Required for Adenovirus Vector: IFN-γ Inhibition of Herpes Simplex Virus-1 in Cornea1 (2007) (10)
Testicular cancer in association with developmental renal anomalies and hypospadias. (1996) (10)
siRNA delivery not Toll-free (2009) (10)
Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. (1992) (10)
Activating transcription factor 3 contributes to Toll-like receptor-mediated macrophage survival via repression of Bax and Bak. (2013) (10)
RFLP detected by an X-linked cDNA encoding erythroid-potentiating activity/tissue inhibitor of metalloproteinase (EPA/TIMP). (1986) (10)
Induced factor binding to the interferon-stimulated response element. Interferon-alpha and platelet-derived growth factor utilize distinct signaling pathways. (1991) (10)
OAS and PKR are not required for the antiviral effect of Ad:IFN-gamma against acute HSV-1 in primary trigeminal ganglia cultures. (2006) (10)
Overexpression of mouse p140 subunit of replication factor C accelerates cellular proliferation. (1996) (9)
Immunology. A viral on/off switch for interferon. (2003) (9)
Dynamiting viruses with MxA. (2011) (9)
The 2-5A system. Molecular and clinical aspects of the interferon-regulated pathway. Proceedings of the Sixth International Symposium of the Research Institute, Hospital for Sick Children. Toronto, Ontario, Canada, June 305, 1985. (1985) (9)
Making sense of viral RNA sensing. (2011) (9)
Antiviral response in insects? (1977) (8)
NF- k B Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF- k B-Inducing Kinase and I k B Kinase (2000) (8)
Multiple tumor suppressor genes in multistep carcinogenesis. (1992) (8)
Auto-phosphorylation Represses Protein Kinase R Activity (2017) (8)
The role of NF-kappaB in the regulation of the expression of wilms tumor suppressor gene WT1. (2001) (8)
Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea. (2007) (7)
Mechanisms and consequences of constitutive activation of integrin-linked kinase in acute myeloid leukemia. (2018) (7)
Clinical Presentation and Treatment (1995) (7)
Erratum: Poly(dI·C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFκB and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR (The Journal of Biological Chemistry (2003) 278 (16713-1671 (2003) (7)
Gene modulatory effects, pharmacokinetics, and clinical tolerance of interferon-alpha1b: a second member of the interferon-alpha family. (2007) (7)
Transcriptional activation of human (2'-5')oligoadenylate synthetase gene expression by the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate in type-I-interferon-treated HL-60 and HeLa cells. (1992) (7)
Growth inhibitory effect of gene-cloned interferons on human myeloblast colonies. (1985) (7)
Biochemical analyses of multiple fractions of PKR purified from Escherichia coli. (2004) (7)
Interferon and phorbol esters down‐regulate slgM expression by independent pathways (1988) (6)
Differential binding of human interferon-alpha subtypes to receptors on lymphoblastoid cells. (1983) (6)
Interferon-α Activates Binding of Nuclear Factors to a Sequence Element in the c-fos Proto-Oncogene 5′-Flanking Region (1992) (6)
Interferon-α Activates Binding of Nuclear Factors to a Sequence Element in the c-fos Proto-Oncogene 5′-Flanking Region (1992) (6)
Procedures for the assay of (2'-5')-oligoadenylic acids and their derivatives in intact cells. (1981) (6)
Cell-free protein synthesis and interferon action: protein kinase(s) and an oligonucleotide effector, pppA2'p5'A2'p5'A. (1979) (5)
The effect of interferon on cells deficient in nucleoside transport or lacking thymidine kinase activity. (1984) (5)
Production and characterization of a monoclonal antibody to a human interferon-induced double-stranded RNA-binding Mr 68,000 protein kinase. (1985) (5)
Analysis of WT1 gene expression during mouse nephrogenesis in organ culture (1996) (5)
Signal transduction and transcriptional regulation of interferon-alpha-stimulated genes. (1991) (5)
Regulation of double-stranded RNA dependent protein kinase expression and attenuation of protein synthesis induced by bacterial toll-like receptors agonists in the absence of interferon. (2012) (4)
In vitro hyporeactivity to α-interferon in children with severe combined immunodeficiency disease (1984) (4)
The subcellular localization of the changes in ribonuclease and phosphatase activities of the mouse kidney produced by castration and testosterone. (1973) (4)
Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation. (2014) (4)
Latest advances in innate antiviral defence (2009) (4)
Differential human interferon alpha receptor expression on proliferating and non-proliferating cells. (1986) (3)
Cell growth-dependent changes in interferon-alpha receptor expression and induction of specific genes. (1985) (3)
The host defense system in the human newborn: the role of interferon and the natural killer cell. (1984) (3)
RNA interference and interferon. (2003) (3)
Antitumor Activity Double-Stranded RNA and CpG DNA Promotes Enhanced Synergistic Activation of Innate Immunity by Updated (2004) (3)
The interaction of interferon-alpha and -gamma: regulation of (2-5)A synthetase activity. (1988) (3)
Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. (1982) (3)
Approval Standards for Alfa Interferon Subtypes (2000) (3)
The role of PKR in dsRNA and interferon signal transduction (1995) (2)
In vitro hyporeactivity to alpha-interferon in children with severe combined immunodeficiency disease. (1984) (2)
Interferon and growth factor modulation of nuclear factors binding to 5′ upstream elements of the 2–5A synthetase gene (1988) (2)
Detection of double-stranded RNA in Semliki Forest virus-infected cells by an indirect solid phase radioimmunoassay: an assay for interferon. (1977) (2)
Type I interferons (IFN) are essential mediators of innate and specific immunity against viruses. (2002) (2)
Developmental and Tissue-Specific Expression Patterns of the Wilms Tumor Suppressor Gene WT1 (1995) (2)
Erratum: 'Human PKR transfected into murine cells stimulates expression of genes under control of the HIV1 or HTLV-1' (Virology (1995) 214 (2)(653- 659)) (1998) (1)
Analysis of WT 1 in Granulosa Cell and Other Sex Cord-Stromal Tumors 1 (2006) (1)
Progress in interferon and cytokine biology. (1998) (1)
Genistein Targets STING-Driven Antiviral Responses (2022) (1)
Enlarged spleens without enlarged lymph nodes in tlr3-/- pkr-/- mice. (2007) (1)
Regulation of miR-155 by Ets 2 1 The role of Ets 2 transcription factor in the induction of microRNA-155 by LPS , and its targeting by IL-10 (2013) (1)
PL2-3 Negative regulation of TLR-mediated NF-κB activation by PLZF (2010) (1)
Interferon-alpha activates binding of nuclear factors to a sequence element in the c-fos proto-oncogene 5'-flanking region. (1992) (1)
1130 REGULATION OF INTERFERON RECEPTOR EXPRESSION ON HUMAN LYMPHOCYTES (1985) (1)
Targeting RNA for degradation with a (2',5')-oligoadenylate antisense chimera (1995) (1)
Integrin-Linked Kinase Expression Characterizes the Immunosuppressive Tumor Microenvironment in Colorectal Cancer and Regulates PD-L1 Expression and Immune Cell Cytotoxicity (2022) (1)
3: Role of Integrin-linked kinase in innate immunity and in inflammatory diseases (2014) (1)
Lnc(ing) interferon production and action (2019) (1)
3: Integrin-linked kinase modulates LPS-induced TNFα production via regulation of p65 phosphorylation at serine 536 during NF-kB activation (2013) (1)
Faculty of 1000 evaluation for CRISPR RNAs trigger innate immune responses in human cells. (2018) (0)
CS17-2. Regulation of the Actin Modifier Gelsolin by Protein Kinase R Enforces Basal Innate Immune Defense (2011) (0)
Macrophages Sensing of Single-Stranded RNAs in Human TLR 7 Is Involved in Sequence-Specific (2008) (0)
Other Loci Implicated in Wilms Tumor (1995) (0)
205: A role for protein kinase R in regulating NLRP3 inflammasome assembly (2014) (0)
Interferon-induced gene expression profiles and clinical response in renal cell carcinoma. (2006) (0)
290: The protein kinase R as a repressor of inflammasome activity (2013) (0)
Faculty Opinions recommendation of ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. (2013) (0)
Selection and characterization of monoclonal antibodies developed to interferon-induced dsRNA-binding proteins. (1985) (0)
CS3-4 Characterisation of microRNA turnover reveals sustained modulation of innate immunity (2010) (0)
Cloning and Characterization of the WT1 Locus (1995) (0)
179: MIRNA analysis reveals novel insights into IL10 function (2013) (0)
Characterization of interferon-regulated pathways using oligonucleotide microarrays (1999) (0)
Faculty Opinions recommendation of Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. (2012) (0)
Faculty Opinions recommendation of RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis. (2011) (0)
419. Rational design of bifunctional siRNAs that silence genes and recruit the innate immune system to treat ectopic pregnancies (2008) (0)
The 2′5′oligoadenylate synthetase, a mutienzyme system involved in the growth properties and the sensitivity to viruses of mammalian cells: selection of antibodies in order to investigate their specific biological roles (1991) (0)
163: Sequence-dependent off-target inhibition of TLR7/8 by synthetic microRNA inhibitors (2014) (0)
PS2-67 PKR: innate immunity and cell biology (2010) (0)
Faculty Opinions recommendation of SLC19A1 Is an Importer of the Immunotransmitter cGAMP. (2019) (0)
Expression of the Wilms’ Tumor Supressor Gene (WT1) in Renal Cell Carcinoma (1995) (0)
Peter Lengyel (1929-2020): A Pioneer Researcher in Protein Synthesis and Interferon Action. (2020) (0)
Arginase-2 is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages at the Mitochondria (2020) (0)
Biochemical analysis of multiple fractions of PKR expressed and purified from E coli (2001) (0)
Faculty of 1000 evaluation for Mitotic progression following DNA damage enables pattern recognition within micronuclei. (2017) (0)
Computational Methods and Bioinformatic Tools (2004) (0)
MODL-17. The Childhood Brain Cancer Cell Line Atlas: A Resource for Biomarker Identification and Therapeutic Development (2022) (0)
Allan S.Y. Lau (1952–2013) A Dedicated Interferon and Cytokine Biologist and Infectious Disease Physician (2013) (0)
ID: 123: PLZF restrains inflammation (2015) (0)
Expressing Murine IFN-VectorVivo Antiviral Effect of an Adenoviral RNA-Dependent Protein Kinase R in the In Synthetases and Double-Stranded-Oligoadenylate ′ , 5 ′ Distinctive Roles for 2 (2004) (0)
Naturally Occurring Mutations in the WTI Gene (1995) (0)
Design of anti-AIDS drugs: Edited by E. De Clercq. Elsevier Science Publishers, Amsterdam. ISBN: 0-444-88179-4, list price US$ 143.50/Dfl. 280.00 (1991) (0)
IFN-Induced and Double-Stranded RNA-Activated Kinase PKR 1 (2000) (0)
CS01-2 microRNAs positively regulate NFκB signalling (2011) (0)
Abstract 4728: Histone deacetylase inhibitors induce apoptosis in multiple tumor types through induction of ATF3 (2016) (0)
Differentiating the interferon pathway (2010) (0)
P045 A role for Protein Kinase R in regulating NLRP3 inflammasome signaling pathway (2012) (0)
Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry (2017) (0)
Abstract 387: Activating transcription factor 3 (ATF-3) expression is a potential marker of tumor response to the HDAC inhibitor Pracinostat (2014) (0)
Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer. (2017) (0)
Efficient suppression of secretory clusterin levels by polymersiRNA polymersiRNA polymersiRNA nanocomplexes enhances ionizing radiation lethality in human MCF7 MCF7 MCF7 breast cancer cells in vitro * (2006) (0)
PL1-6 PKR-Dependent control of obesity-related disease (2010) (0)
Rapid Detection of Cellular Responses to Biological Agents (2003) (0)
Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern (2023) (0)
Herpes Simplex Virus Type 1 Replication Interferon Transgenes on Antagonization of Differential Effect of Murine Alpha / Beta (2002) (0)
Faculty Opinions recommendation of Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. (2014) (0)
SY-9 Stimulation of innate immunity by short interfering and micro RNAs (2008) (0)
2-5A-Antisense: A Novel Approach to Cancer Therapy (1995) (0)
6 New pathway for IRF-3-activation by RIG-I that causes its mitochondrial translocation and apoptosis (2008) (0)
Protein Kinases and the 2-5A System in Interferon-Treated and Control Cells (1979) (0)
ANTIPROLIFERATIVE PROPERTIES OF GENE-CLONED ALPHA INTERFERON IN ACUTE LEUKEMIA (1984) (0)
Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients (2017) (0)
Cellular Functions of WT1 (1995) (0)
Induction of Nitric Oxide Synthase RNA-Activated Protein Kinase in Microbial Central Role of Double-Stranded (2000) (0)
P117 Regulation of actin dynamics by Protein Kinase R control of gelsolin enforces basal innate immune defense (2012) (0)
PS2-46 Expression and activation of protein kinase PKR and its role in the inhibition of global synthesis induced by bacterial agonists (2010) (0)
Cre-dependent DNA recombination activates cGAS-STING innate immune response (2016) (0)
225: Inosine-mediated modulation of RNA sensing by innate immune sensors (2013) (0)
PS3-11 Selective recognition of RNA by the retinoic acid inducible gene I receptor (2010) (0)
Kinase PKR Activity of Double-Stranded RNA-Activated Potential Alu Function : Regulation of the (1997) (0)
Faculty Opinions recommendation of Targeting the tumor microenvironment with interferon-β bridges innate and adaptive immune responses. (2014) (0)
CS03-1. Regulation of Interferon and Cytokine Signaling by Transcription Factor PLZF (2011) (0)
P101 The role of MDA5 and the effect of rotavirus in type 1 diabetes (2012) (0)
Faculty Opinions recommendation of Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo. (2007) (0)
The role of PLZF in shaping oncogenic characteristics of cancer cells (2011) (0)
RNA-Activated Kinase PKR by the IFN-Induced and Double-Stranded T Cell Function + Negative Regulation of CD 8 (2000) (0)
189 Protein kinase R-dependent regulation of c-JUN and EGR-1 in response to double-stranded RNA (2008) (0)
17 PKR-dependent Regulation of IL-10 in Response to Double-stranded RNA (2007) (0)
PS2-009. PKR-dependent, actin-mediated defects in cells of the hematopoetic system (2011) (0)
Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities. (2023) (0)
Interferon-associated enzyme (2'-5'A synthetase) levels in infection and altered immune states (1982) (0)
RNAinterference in biology and disease (2005) (0)
ISG database - interferon-stimulated gene database (2003) (0)
The role of cytosolic phospholipase A2 in signal transduction by interferon (1996) (0)

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