C. erik Hack
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Philosophy
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(Suggest an Edit or Addition)C. erik Hack's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia. (1997) (805)
- Activation of coagulation after administration of tumor necrosis factor to normal subjects. (1990) (710)
- Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation (2001) (664)
- Increased plasma levels of interleukin-6 in sepsis [see comments] (1989) (661)
- Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. (2000) (608)
- Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways (1990) (529)
- Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. (1990) (486)
- Increased plasma levels of interleukin-6 in sepsis. (1989) (475)
- SERUM LEVELS OF INTERLEUKIN-6 AND ACUTE PHASE RESPONSES (1987) (466)
- Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. (1994) (452)
- Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. (1989) (431)
- Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees (1994) (408)
- Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. (1997) (371)
- Complement activation plays a key role in the side‐effects of rituximab treatment (2001) (320)
- Interleukin-8 in sepsis: relation to shock and inflammatory mediators (1992) (319)
- Role of cytokines in sepsis. (1997) (316)
- Human cell‐derived microparticles promote thrombus formation in vivo in a tissue factor‐dependent manner (2003) (303)
- Proinflammatory Effects of IL-10 During Human Endotoxemia1 (2000) (297)
- Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans (1996) (297)
- C1-Esterase inhibitor: an anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema. (2000) (292)
- Disseminated intravascular coagulation in sepsis. (2005) (291)
- Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia. (2000) (276)
- Microparticles from Patients with Multiple Organ Dysfunction Syndrome and Sepsis Support Coagulation through Multiple Mechanisms (2001) (275)
- Fibrinolytic response to tumor necrosis factor in healthy subjects (1991) (260)
- CRP-mediated activation of complement in vivo: assessment by measuring circulating complement-C-reactive protein complexes. (1996) (257)
- Elevated nucleosome levels in systemic inflammation and sepsis* (2003) (244)
- Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracorporeal perfusion. (1993) (222)
- Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis. (1992) (221)
- Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: effect of interventions in the cytokine and coagulation cascades. (1995) (221)
- Serine proteases of the human immune system in health and disease. (2010) (218)
- Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis. (1989) (216)
- P-selectin- and CD63-exposing platelet microparticles reflect platelet activation in peripheral arterial disease and myocardial infarction. (2006) (215)
- Quantification of plasma factor XIIa-Cl(-)-inhibitor and kallikrein-Cl(-)-inhibitor complexes in sepsis. (1988) (213)
- Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism. (2002) (210)
- IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The EPIC-Norfolk Prospective Population Study (2004) (202)
- Granulocyte colony-stimulating factor administration to healthy volunteers: analysis of the immediate activating effects on circulating neutrophils. (1994) (201)
- Enhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In vivo evidence for a role of factor XI as an anti-fibrinolytic factor. (1998) (195)
- Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock. (1998) (192)
- Functional characterization of the lectin pathway of complement in human serum. (2003) (190)
- Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. (2001) (189)
- C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003. (2006) (186)
- Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. (1994) (180)
- Local activation of coagulation and inhibition of fibrinolysis in the lung during ventilator associated pneumonia (2004) (177)
- Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease. (1996) (177)
- Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli. (2000) (177)
- Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. (1995) (175)
- Effect of a recombinant dimeric tumor necrosis factor receptor on inflammatory responses to intravenous endotoxin in normal humans. (1997) (174)
- Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. (2006) (170)
- Anti-Inflammatory Effects of a p38 Mitogen-Activated Protein Kinase Inhibitor During Human Endotoxemia1 (2002) (166)
- The Granzyme B Inhibitor, Protease Inhibitor 9, Is Mainly Expressed by Dendritic Cells and at Immune-Privileged Sites1 (2001) (165)
- Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? (2002) (164)
- Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia. (1997) (161)
- ADAMTS‐13, von Willebrand factor and related parameters in severe sepsis and septic shock (2007) (159)
- Proteolytic inactivation of plasma C1- inhibitor in sepsis. (1989) (156)
- Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: major role for C1-inhibitor. (1995) (152)
- Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor (1999) (149)
- Time course of cytokine levels in sepsis (1995) (145)
- Chromatin-Independent Binding of Serum Amyloid P Component to Apoptotic Cells (2001) (141)
- Evidence That Complement Protein C1q Interacts with C-Reactive Protein through Its Globular Head Region1 (2006) (137)
- Potentiation of C1 inhibitor by glycosaminoglycans: dextran sulfate species are effective inhibitors of in vitro complement activation in plasma. (1997) (135)
- IC14, an Anti-CD14 Antibody, Inhibits Endotoxin-Mediated Symptoms and Inflammatory Responses in Humans1 (2001) (134)
- TAFI and PAI-1 levels in human sepsis. (2006) (134)
- Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. (2002) (132)
- Serum Levels of Type II Secretory Phospholipase A2 and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The EPIC-Norfolk Prospective Population Study (2005) (128)
- A soluble form of the human T cell differentiation antigen CD27 is released after triggering of the TCR/CD3 complex. (1991) (128)
- Application of a monoclonal antibody against a neoepitope on activated C4 in an ELISA for the quantification of complement activation via the classical pathway. (1993) (127)
- Extracellular granzymes A and B in humans: Detection of native species during CTL responses in vitro and in vivo (1998) (125)
- Inflammatory mediators in dengue virus infection in children: interleukin-6 and its relation to C-reactive protein and secretory phospholipase A2. (2001) (124)
- Interleukin-6 and its relation to the humoral immune response and clinical parameters in burned patients. (1991) (123)
- Inflammatory Mediators in Dengue Virus Infection in Children: Interleukin-8 and Its Relationship to Neutrophil Degranulation (2000) (123)
- Reduction of contact activation related fibrinolytic activity in factor XII deficient patients. Further evidence for the role of the contact system in fibrinolysis in vivo. (1991) (120)
- Interleukin-1 blockade attenuates mediator release and dysregulation of the hemostatic mechanism during human sepsis. (1995) (119)
- Inhibition of factor XII in septic baboons attenuates the activation of complement and fibrinolytic systems and reduces the release of interleukin-6 and neutrophil elastase. (1996) (118)
- A hinge region mutation in C1-inhibitor (Ala436-->Thr) results in nonsubstrate-like behavior and in polymerization of the molecule. (1993) (115)
- Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation. (2007) (113)
- Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections (2005) (113)
- Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections (2003) (111)
- Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. (2000) (109)
- Heparin coating of extracorporeal circuits inhibits contact activation during cardiac operations. (1997) (109)
- Plasminogen Activation In Vivo upon Intravenous Infusion of DDAVP (1992) (106)
- The plasma kallikrein–kinin system and risk of cardiovascular disease in men (2007) (104)
- Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study. (2004) (102)
- Activated complement components and complement activator molecules on the surface of cell-derived microparticles in patients with rheumatoid arthritis and healthy individuals (2007) (102)
- Granzymes Regulate Proinflammatory Cytokine Responses (2015) (100)
- Effect of C1 inhibitor on inflammatory and physiologic response patterns in primates suffering from lethal septic shock. (1998) (99)
- Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection. (1995) (98)
- C1-inhibitor in patients with severe sepsis and septic shock: Beneficial effect on renal dysfunction (2002) (98)
- Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: relation to plasma levels of interleukin-10 and interferon-gamma. (1996) (95)
- Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model (1993) (94)
- Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect. (2001) (94)
- Relevance of classic anti‐neutrophil cytoplasmic autoantibody (C‐ANCA)‐mediated inhibition of proteinase 3‐α1‐antitrypsin complexation to disease activity in Wegener's granulomatosis (1993) (93)
- Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. (1996) (93)
- Modulation of Contact System Proteases by Glycosaminoglycans (1996) (91)
- Effects on leukocytes after injection of tumor necrosis factor into healthy humans (1992) (90)
- Prediction of mortality in febrile medical patients: How useful are systemic inflammatory response syndrome and sepsis criteria? (1998) (90)
- Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity (1992) (90)
- Activation patterns of coagulation and fibrinolysis in baboons following infusion with lethal or sublethal dose of Escherichia coli. (1993) (89)
- The inflammatory response to vascular surgery-associated ischaemia and reperfusion in man: effect on postoperative pulmonary function. (1997) (88)
- Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees. (1999) (86)
- Complement activation in patients with rheumatoid arthritis mediated in part by C-reactive protein. (2001) (86)
- Complement activation in patients with sepsis is in part mediated by C-reactive protein. (1998) (85)
- Activation of the complement system during immunotherapy with recombinant IL-2. Relation to the development of side effects. (1990) (85)
- PAI-1 Synthesis in the Human Hepatoma Cell Line Hep G2 Is Increased by Cytokines - Evidence that the Liver Contributes to Acute Phase Behaviour of PAI-1 (1991) (84)
- Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins. (1993) (84)
- Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. (2003) (82)
- Circulating inflammatory mediators predict shock and mortality in febrile patients with microbial infection. (2002) (80)
- Activation of the Intrinsic Pathway of Coagulation in Children with Meningococcal Septic Shock (1995) (80)
- Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations. (2008) (79)
- The distortive mechanism for the activation of complement component C1 supported by studies with a monoclonal antibody against the "arms" of C1q. (1988) (79)
- Activation of Clotting Factors XI and IX in Patients With Acute Myocardial Infarction (2000) (78)
- Clearance of human native, proteinase-complexed, and proteolytically inactivated C1-inhibitor in rats. (1993) (78)
- Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease (2003) (77)
- Early Inhibition of Activated Fibrinolysis Predicts Microbial Infection, Shock and Mortality in Febrile Medical Patients (2001) (76)
- Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase. (2000) (76)
- Interleukin-6 release and the acute-phase reaction in patients with acute myocardial infarction: a pilot study. (1992) (75)
- Effects on leukocytes after injection of tumor necrosis factor into healthy humans. (1992) (75)
- Structure/Function Analysis of Human Factor XII Using Recombinant Deletion Mutants (1996) (75)
- Effects of interferon‐alpha (IFN‐α) administration on leucocytes in healthy humans (1997) (74)
- Elevated levels of total and dengue virus‐specific immunoglobulin E in patients with varying disease severity (2003) (74)
- Activation of the complement system in baboons challenged with live Escherichia coli: correlation with mortality and evidence for a biphasic activation pattern (1993) (73)
- Assessment of the Relative Contribution of Different Protease Inhibitors to the Inhibition of Plasmin In Vivo (1993) (73)
- Expression of Human Recombinant Granzyme A Zymogen and Its Activation by the Cysteine Proteinase Cathepsin C (*) (1996) (72)
- Antithrombin Acts as a Negative Acute Phase Protein as Established with Studies on HepG2 Cells and in Baboons (1997) (72)
- Administration of C1 Inhibitor Reduces Neutrophil Activation in Patients with Sepsis (2003) (71)
- Sustained activation of neutrophils in the course of Kawasaki disease: an association with matrix metalloproteinases (2005) (71)
- Chemoattractant and neutrophil degranulation activities related to interleukin-8 in vitreous fluid in uveitis and vitreoretinal disorders. (1993) (70)
- Serum Levels of Mannose-Binding Lectin and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women (2006) (69)
- Pro‐ and non‐coagulant forms of non‐cell‐bound tissue factor in vivo (2003) (69)
- Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees. (1993) (69)
- Proinflammatory cytokines and elastase-alpha-1-antitrypsin in Argentine hemorrhagic fever. (1999) (68)
- Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay. (2006) (68)
- Localization and identification of granzymes A and B‐expressing cells in normal human lymphoid tissue and peripheral blood (1995) (66)
- Interleukin 8-related neutrophil elastase and the severity of the adult respiratory distress syndrome. (1995) (66)
- C1 inhibitor hinge region mutations produce dysfunction by different mechanisms (1992) (65)
- Regulation of Complement Activation by C-Reactive Protein: Targeting of the Inhibitory Activity of C4b-Binding Protein1 (2006) (65)
- Analysis of intraarticular fibrinolytic pathways in patients with inflammatory and noninflammatory joint diseases. (1992) (63)
- Specific complement inhibition with heparin-coated extracorporeal circuits. (1996) (63)
- Structural and functional aspects of C1-inhibitor. (2002) (61)
- Complement activation during OKT3 treatment: a possible explanation for respiratory side effects. (1993) (61)
- Evaluation of classical complement pathway activation in rheumatoid arthritis: measurement of C1q-C4 complexes as novel activation products. (2006) (61)
- Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model (2006) (61)
- Monomeric IgG in Intravenous Ig Preparations Is a Functional Antagonist of FcγRII and FcγRIIIb (2004) (61)
- Interleukin 12 levels during the initial phase of septic shock with purpura in children: relation to severity of disease. (1997) (60)
- Endotoxin and Tumor Necrosis Factor-α-Induced Interleukin-8 Release in Humans (1993) (58)
- Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. (2004) (58)
- Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor. (1996) (57)
- Monocyte chemotactic protein 1 is released during lethal and sublethal bacteremia in baboons. (1995) (56)
- IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer. (1996) (56)
- Detection of Activation of the Contact System of Coagulation In Vitro and In Vivo: Quantitation of Activated Hageman Factor-C1-Inhibitor and Kallikrein-C1-Inhibitor Complexes by Specific Radioimmunoassays (1987) (56)
- Detection of soluble human granzyme K in vitro and in vivo (2005) (56)
- Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction. (2005) (56)
- Effect of hypertriglyceridemia on endotoxin responsiveness in humans (1995) (56)
- Ischemia induces nuclear NOX2 expression in cardiomyocytes and subsequently activates apoptosis (2006) (55)
- Human eosinophils express, relative to other circulating leukocytes, large amounts of secretory 14-kD phospholipase A2. (1998) (55)
- Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae. (2000) (55)
- Granzyme Activity in the Inflamed Lung Is Not Controlled by Endogenous Serine Proteinase Inhibitors1 (2000) (55)
- Neutrophil responsiveness to IgG, as determined by fixed ratios of mRNA levels for activating and inhibitory FcgammaRII (CD32), is stable over time and unaffected by cytokines. (2006) (54)
- Platelet-activating factor antagonist TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzees. (1994) (54)
- Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors. (2000) (54)
- Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. (1999) (54)
- The Impact of Heparin-Coated Cardiopulmonary Bypass Circuits on Pulmonary Function and the Release of Inflammatory Mediators (2004) (53)
- Longstanding obliterative panarteritis in Kawasaki disease: lack of cyclosporin A effect. (2003) (53)
- Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes (2014) (52)
- Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation. (1995) (52)
- C1-inhibitor substitution therapy in septic shock and in the vascular leak syndrome induced by high doses of interleukin-2 (2005) (51)
- Rat C‐reactive protein activates the autologous complement system (2003) (51)
- Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever (2001) (50)
- Liver failure induces a systemic inflammatory response. Prevention by recombinant N-terminal bactericidal/permeability-increasing protein. (1995) (49)
- Cerebral and Hepatic Inflammatory Response after Neonatal Hypoxia-Ischemia in Newborn Rats (2013) (49)
- Interplay of complement and cytokines in the pathogenesis of septic shock. (1992) (49)
- Activation of clotting factor XI without detectable contact activation in experimental human endotoxemia. (1998) (49)
- Complement activation by necrotic cells in normal plasma environment compares to that by late apoptotic cells and involves predominantly IgM (2004) (49)
- Identification of a Putative Binding Site for Negatively Charged Surfaces in the Fibronectin Type II Domain of Human Factor XII (2000) (47)
- Contribution of interleukin-1 to activation of coagulation and fibrinolysis, neutrophil degranulation, and the release of secretory-type phospholipase A2 in sepsis: studies in nonhuman primates after interleukin-1 alpha administration and during lethal bacteremia. (1995) (47)
- Circulating Inflammatory Mediators in Patients with Fever: Predicting Bloodstream Infection (2001) (47)
- The activation of polymorphonuclear neutrophils and the complement system during immunotherapy with recombinant interleukin-2. (1992) (46)
- Elevated serum IL-8 levels are associated with disease activity in idiopathic intermediate uveitis (1998) (46)
- Acute lung injury after aortic surgery: the relation between lung and leg microvascular permeability to 111indium-labelled transferrin and circulating mediators. (1997) (46)
- Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. (2006) (46)
- Effect of factor Xa inhibitors on thrombin formation and complement and neutrophil activation during in vitro extracorporeal circulation. (1996) (45)
- Early Markers of Blood Coagulation and Fibrinolysis Activation in Argentine Hemorrhagic Fever (1995) (45)
- Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia. (2001) (45)
- Effect of whole and fractionated intravenous immunoglobulin on complement in vitro. (1997) (44)
- Expression of functional human C1 inhibitor in COS cells. (1988) (44)
- Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans. (2003) (44)
- Inhibition of Plasmin Activity by Tranexamic Acid Does Not Influence Inflammatory Pathways During Human Endotoxemia (2004) (44)
- Inactivation of C-1 inhibitor by proteases: demonstration by a monoclonal antibody of a neodeterminant on inactivated, non-complexed C-1 inhibitor. (1987) (43)
- In vitro interaction of C1-inhibitor with thrombin (2001) (43)
- Structure/function analysis of human factor XII using recombinant deletion mutants. Evidence for an additional region involved in the binding to negatively charged surfaces. (1996) (43)
- Initial studies on the administration of C1-esterase inhibitor to patients with septic shock or with a vascular leak syndrome induced by interleukin-2 therapy. (1994) (42)
- The clinical host response to microbial infection in medical patients with fever. (1999) (41)
- Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. (2004) (41)
- Structure and function of C1-inhibitor. (2006) (41)
- Levels of natural IgM antibodies against phosphorylcholine in healthy individuals and in patients undergoing isolated limb perfusion. (2004) (40)
- Characterization of recombinant C1 inhibitor P1 variants. (1992) (40)
- Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B. (1992) (40)
- Coagulation disorders in septic shock (2005) (39)
- Quantification of Functional and Inactivated α2-Macroglobulin in Sepsis (1991) (39)
- Multiple organ failure in septic shock. (1996) (39)
- Complexes between C1q and C3 or C4: novel and specific markers for classical complement pathway activation. (2005) (37)
- The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells (2005) (36)
- The role of factor XI in coagulation: a matter of revision. (1999) (36)
- Predominant Role of Neutrophils in the Inactivation of α2‐Macroglobulin in Arthritic Joints (1991) (36)
- The potentiation of human C1-inhibitor by dextran sulphate is transient in vivo: studies in a rat model. (2001) (35)
- Transient increase in interleukin-8 and pulmonary microvascular permeability following aortic surgery. (1995) (34)
- Thrombin and Human Plasma Kallikrein Inhibition during Simulated Extracorporeal Circulation Block Platelet and Neutrophil Activation (1998) (34)
- Proteolytic inactivation of α1-antitrypsin and α1-antichymotrypsin by neutrophils in arthritic joints (1993) (34)
- Determination of proteinase 3—α1‐antitrypsin complexes in inflammatory fluids (1992) (34)
- Infliximab treatment reduces complement activation in patients with rheumatoid arthritis (2005) (33)
- The Functional Integrity of the Serpin Domain of C1-inhibitor Depends on the Unique N-terminal Domain, as Revealed by a Pathological Mutant* (2003) (33)
- Neutrophil activation in ivermectin‐treated onchocerciasis patients (1993) (32)
- The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation. (2005) (32)
- C-reactive protein and interleukin-6 are elevated in onchocerciasis patients after ivermectin treatment. (1994) (32)
- Lymphocytic inflammation in childhood bronchiolitis obliterans (2004) (31)
- Inactivation of Factor XIa in Vivo: Studies in Chimpanzees and in Humans (1996) (31)
- The effect of pseudomonas exotoxin A on cytokine production in whole blood exposed to Pseudomonas aeruginosa. (2000) (31)
- Fat Emulsion Infusion Potentiates Coagulation Activation during Human Endotoxemia (1996) (31)
- Therapeutic inhibition of the early phase of complement activation. (2002) (31)
- The Orchestra of Mediators in the Pathogenesis of Septic Shock: A Review (1991) (30)
- Polyethylene glycol enhances the binding of C1q to circulating immune complexes. (1981) (30)
- Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis (2007) (30)
- Mannan binding lectin in febrile adults: no correlation with microbial infection and complement activation (2003) (30)
- A new principle for rapid immunoassay of proteins based on in situ precipitate-enhanced ellipsometry. (1999) (29)
- Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant (2004) (29)
- Interleukin-6 Downregulates Factor XII Production by Human Hepatoma Cell Line (HepG2) (1997) (29)
- Protective effect of antithrombin III in acute experimental pancreatitis in rats (1992) (28)
- Systemic Coagulation and Fibrinolysis in Patients with or at Risk for the Adult Respiratory Distress Syndrome (1997) (28)
- Transient Increase in Interleukin-8 and Pulmonary Microvascular Permeability following Aortic Surgery (1995) (28)
- The Influence of Insulin, ß-Estradiol, Dexamethasone and Thyroid Hormone on the Secretion of Coagulant and Anticoagulant Proteins by HepG2 Cells (1995) (28)
- Distribution of the Human Intracellular Serpin Protease Inhibitor 8 in Human Tissues (2002) (28)
- Lack of activation of C1, despite circulating immune complexes detected by two C1q methods, in patients with rheumatoid arthritis. (1984) (28)
- IgG Antibodies in Food Allergy Influence Allergen–Antibody Complex Formation and Binding to B Cells: A Role for Complement Receptors (2013) (28)
- Cell-Derived Microparticles and Complement Activation in Preeclampsia Versus Normal Pregnancy (2007) (27)
- Relative contribution of contact and complement activation to inflammatory reactions in arthritic joints. (1992) (27)
- Competitive binding of pentraxins and IgM to newly exposed epitopes on late apoptotic cells. (2006) (27)
- C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. (2007) (27)
- Factor XIII in severe sepsis and septic shock. (2007) (27)
- Release of leukemia inhibitory factor in primate sepsis. Analysis of the role of TNF-alpha. (1996) (27)
- Population pharmacokinetics of recombinant human C1 inhibitor in patients with hereditary angioedema. (2013) (27)
- Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor. (2003) (26)
- A Novel Sensitive Assay for Functional Factor XII Based on the Generation of Kallikrein-C1-lnhibitor Complexes in Factor Xll-Deficient Plasma by Glass-Bound Factor XII (1992) (26)
- Interleukin-6 downregulates factor XII production by human hepatoma cell line (HepG2). (1997) (25)
- Formation of C3-IgG complexes in serum by aggregated IgG and by non-immunoglobulin activators of complement. (1987) (25)
- Monoclonal antibody F1 binds to the kringle domain of factor XII and induces enhanced susceptibility for cleavage by kallikrein. (1995) (25)
- Quantification of amyloid-beta 40 in cerebrospinal fluid. (2009) (25)
- Interleukin 12 induces activation of fibrinolysis and coagulation in humans (2001) (24)
- A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2. (1994) (23)
- Activation of the contact system of coagulation by a monoclonal antibody directed against a neodeterminant in the heavy chain region of human coagulation factor XII (Hageman factor). (1989) (23)
- α1-Antitrypsin Pittsburgh (Met358 → Arg) Inhibits the Contact Pathway of Intrinsic Coagulation and Alters the Release of Human Neutrophil Elastase during Simulated Extracorporeal Circulation (1994) (23)
- Activation of Mononuclear Cells by Interleukin-12: An In Vivo Study in Chimpanzees (1999) (22)
- Complement fragments C3b and iC3b coupled to latex induce a respiratory burst in human neutrophils. (1990) (22)
- The second exon-encoded factor XII region is involved in the interaction of factor XII with factor XI and does not contribute to the binding site for negatively charged surfaces. (1998) (22)
- Peripheral circulation in septic shock. (1989) (21)
- Granzyme expression in fine‐needle aspirates from liver allografts is increased during acute rejection (2002) (21)
- Reduction of circulating secretory phospholipase A2 levels by anti-tumor necrosis factor chimeric monoclonal antibody in patients with severe Crohn's disease. Relation between tumor necrosis factor and secretory phospholipase A2 in healthy humans and in active Crohn's disease. (1998) (21)
- Factor XIa Induced Activation of the Intrinsic Cascade In Vivo (1996) (21)
- Coagulopathy following major liver resection: the effect of rBPI21 and the role of decreased synthesis of regulating proteins by the liver. (2001) (20)
- Endotoxin and tumor necrosis factor-alpha-induced interleukin-8 release in humans. (1993) (20)
- A baboon model for hematologic studies of cardiopulmonary bypass. (1997) (19)
- The IgG detected in the C1q solid-phase immune-complex assay is not always of immune-complex nature. (1986) (19)
- Interferon‐γ in healthy subjects: selective modulation of inflammatory mediators (2001) (18)
- Granzymes A and K differentially potentiate LPS-induced cytokine response (2016) (18)
- In vivo interaction of endotoxin and recombinant bactericidal/permeability-increasing protein (rBPI23): hemodynamic effects in a human endotoxemia model. (2002) (18)
- Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils. (1993) (18)
- Modulation of Contact System Proteases by Glycosaminoglycans SELECTIVE ENHANCEMENT OF THE INHIBITION OF FACTOR XIa* (1996) (18)
- Production, characterization, and use of serpin antibodies. (2004) (18)
- Predominant role of neutrophils in the inactivation of alpha 2-macroglobulin in arthritic joints. (1991) (17)
- Cell-derived microparticles and complement activation in preeclampsia versus normal pregnancy. (2007) (17)
- Is major liver surgery associated with an increased systemic inflammatory response? A prospective comparison of hemihepatectomy and other major abdominal surgery. (1999) (17)
- Enoxaparin suppresses thrombin formation and activity during cardiopulmonary bypass in baboons. (1998) (17)
- Phosphorylcholine coating of bypass systems used for young infants does not attenuate the inflammatory response. (2006) (16)
- Critical micelle concentrations and stirring are rate limiting in the loss of lipid mass during membrane degradation by phospholipase A2. (1996) (16)
- Relation between coagulation/fibrinolysis and lactate in the course of human septic shock (2010) (16)
- Inhibition of the Classical and Lectin Pathway of the Complement System by Recombinant LAIR-2 (2013) (15)
- Clearance of human factor XIa–inhibitor complexes in rats (1996) (15)
- Effects of Heparin Therapy on Fibrinolysis in Patients with Pulmonary Embolism (1997) (15)
- Proteinase 3: substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme. (1993) (15)
- Quantification of functional and inactivated alpha 2-macroglobulin in sepsis. (1991) (15)
- Tumor necrosis factor unresponsiveness after surgery in bile duct-ligated rats. (1996) (14)
- Effect of postponed treatment with an anti‐tumour necrosis factor (TNF) F(ab')2 fragment on endotoxin‐induced cytokine and neutrophil responses in chimpanzees (1995) (14)
- Pretreatment with a 55-kDa tumor necrosis factor receptor-immunoglobulin fusion protein attenuates activation of coagulation, but not of fibrinolysis, during lethal bacteremia in baboons. (1997) (14)
- Estrogen Replacement Raises Rat CRP Without Evidence of Complement Activation (2005) (13)
- Production of monoclonal antibodies against inactivated α1-antitrypsin: Cross-reactivity with complexed α1-antitrypsin and application in an assay to determine inactivated and complexed α1-antitrypsin in biological fluids (1991) (13)
- Inflammatory response and optimalisation of perioperative fluid administration during hyperthermic intraoperative intraperitoneal chemotherapy surgery. (2019) (13)
- A novel proinflammatory role for granzyme A (2017) (13)
- Thalidomide Inhibits Granulocyte Responses in Healthy Humans after Ex Vivo Stimulation with Bacterial Antigens (2001) (13)
- Role of complement in graft rejection after organ transplantation. (2002) (13)
- Partial coverage of phospholipid model membranes with annexin V may completely inhibit their degradation by phospholipase A2 (1997) (13)
- Increased plasma levels of PAI-1 after administration of nonionic contrast medium in patients undergoing pulmonary angiography. (1994) (13)
- The Role of the Contact System in the Pathogenesis of Septic Shock (1999) (12)
- Endotoxin-induced neutrophil activation--the role of complement revisited. (1991) (12)
- Impaired leukocyte phagocytosis in patients undergoing hemihepatectomy for liver metastases. (1999) (12)
- A progress report of a phase I study of interferon-gamma and interleukin-2 and some comments on the mechanism of the toxicity due to interleukin-2. (1989) (11)
- Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study (2018) (11)
- Elastase and granzymes during meningococcal disease in children: correlation to disease severity (2005) (11)
- Thrombin‐mediated activation of endogenous factor XI in plasma in the presence of physiological glycosaminoglycans occurs only with high concentrations of thrombin (1996) (10)
- IVIg-mediated amelioration of murine ITP via FcgammaRIIb is not necessarily independent of SHIP-1 and SHP-1 activity. (2004) (10)
- A model for the interplay of inflammatory mediators in sepsis —a study in 48 patients (2005) (10)
- Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC‐Norfolk prospective population study (2006) (10)
- Activation of the contact system of coagulation does not contribute to the hemostatic imbalance in hypertriglyceridemia. (1999) (10)
- Proteolytic inactivation of alpha 1-antitrypsin and alpha 1-antichymotrypsin by neutrophils in arthritic joints. (1993) (9)
- The role of the innate immune response in hospital- versus community-acquired infection in febrile medical patients. (2008) (9)
- Biphasic release of secretory phospholipase A2 during and after cardiopulmonary bypass. (1998) (9)
- Endotoxin-induced activation and inhibition of febrinolysis: Effects of various interventions in the cytokine and coagulation cascades in experimental endotoxemia in chimpanzees (1994) (9)
- Separation of different forms of the fourth component of human complement by fast protein liquid chromatography. (1993) (8)
- Influence of C3 level on the determination of C3d in plasma and synovial fluid by radial immunodiffusion. (1986) (8)
- Fibrinolytic Response to lnterferon-a in Healthy Human Subjects (1996) (8)
- Interleukin 10 Release During Endotoxaemia in Chimpanzees: Role of Platelet‐Activating Factor and Interleukin 6 (1996) (8)
- Pharmaceutical proteins from methylotrophic yeasts. (2005) (8)
- Hemostatic markers in healthy postmenopausal women during intranasal and oral hormone therapy: a randomized trial (2008) (7)
- Characterisation of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin’s lymphomas. (2004) (7)
- Molecular Mechanisms of Complement Activation during Ischemia and Reperfusion (2002) (6)
- Towards functional transplant donor matching by measurement of granzyme A and granzyme B production levels. (2004) (6)
- Novel strategy for the selection of human recombinant Fab fragments to membrane proteins from a phage-display library. (2002) (6)
- Studies on the haemolytic activity of circulating C1q-C3/C4 complexes. (2008) (6)
- Role of the Complement Cascade in Severe Sepsis (1992) (6)
- Determination of proteinase 3-alpha 1-antitrypsin complexes in inflammatory fluids. (1992) (5)
- Contact system dependent fibrinolytic activity in vivo: observations in healthy subjects and factor XII deficient patients. (1992) (4)
- Increased prevalence of CMV gB3 in marrow of patients with aplastic anemia (2001) (4)
- Inhibitor substitution in sepsis (2005) (3)
- The Release of Interleukin‐12 in Escherichia co/i‐Induced Lethal and Sublethal Primate Sepsis (1996) (3)
- Innate immunity — phagocytes, natural killer cells and the complement system (2005) (3)
- Production of monoclonal antibodies against inactivated alpha 1-antitrypsin. Cross-reactivity with complexed alpha 1-antitrypsin and application in an assay to determine inactivated and complexed alpha 1-antitrypsin in biological fluids. (1991) (3)
- The balance between inhibition and substrate-type reactions of recombinant C1 inhibitor P5/P3 variants. (1993) (3)
- Role of Complement Activation in Human Sepsis and Septic Shock (1987) (3)
- C 1 Inhibitor Treatment Improves Host Defense in Pneumococcal Meningitis in Rats and Mice (2007) (3)
- Effect of reactive site loop elongation on the inhibitory activity of C1-inhibitor. (2004) (3)
- Inflammatory Mediators in Dengue Virus Infection: Circulating Interleukin-12 and Interferon-? (2002) (2)
- Production, purification and characterisation of recombinant Fahsin, a novel antistasin-type proteinase inhibitor. (2005) (2)
- A randomised, placebo-controlled, double blind phase III study of the efficacy and safety of recombinant human C1 inhibitor for the treatment of acute attacks in patients with hereditary angioedema (2008) (2)
- Bacillus Calmette-Guérin sepsis: shift of an intended local toward a detrimental systemic cytotoxic immune response. (2001) (2)
- Interferon‐gamma administration to patients after major surgery influences cellular immunity without pro‐inflammatory response (2002) (2)
- Disseminated intravascular coagulation in meningococcal sepsis (2003) (2)
- rBPI2, IN THE PREVENTION OF THE INFLAMMATORY RESPONSE AFTER LIVER RESECTION IN PATIENTS: RESULTS OF THE LOW DOSE PHASE.: 635 (1997) (2)
- Inhibition of factor XII in septic baboons attenuates activation of complement and fibrinolytic systems and reduces the release of interleukin-6 (1994) (2)
- C1 ESTERASE INHIBITOR (C1-INH) CAN REDUCE PLASMA CONCENTRATIONS OF THE COMPLEMENT ACTIVATION PRODUCT C5A. AUTHOR'S REPLY (1994) (2)
- Cardiovascular secrets of secretory phospholipase A2 (2002) (2)
- Methylprednisolone induces activation of the contact system in a dose-dependent manner. An in vitro study. (1990) (2)
- Early clinical and laboratory indicators for the development of shock in children with dengue virus infection (1999) (2)
- Characterization of Recombinant C 1 Inhibitor P 1 Variants * (2001) (1)
- Structure and function of Cl-inhibitor (2006) (1)
- Apoptosis In Sepsis And Multiple Organ Dysfunction Syndrome (2004) (1)
- Circulating Granzymes are associated with Bloodstream Infection and Death in Febrile Medical Patients (2007) (1)
- NEUTROPHIL ACTIVATION AND THE ACUTE PHASE RESPONSE IN IVERMECTIN TREATED ONCHOCERCIASIS (1994) (1)
- Accelerated autoantibody clearance by IVIG therapy (2000) (1)
- Healthy Men and Women : The EPIC-Norfolk Prospective Population Study IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in (2004) (1)
- Influence of ionic strength, EDTA concentration, endogenous C1q and polyanions on the 125I-C1q-binding test. (1984) (1)
- [Current viewpoints and hypotheses concerning in vivo blood coagulation]. (1993) (1)
- Shock I (2011) (1)
- Group II secretory PLA2 : A new cardiovascular risk factor (2006) (1)
- The value of haemostatic markers in the triage of patients with chest pain presenting with a normal or non-diagnostic ECG (2005) (1)
- History, biological mechanisms of action and clinical indications of intravenous immunoglobulin (IVIG) preparations (2002) (1)
- OKT3‐induced nephrotoxicity is associated with release of group II secretory phospholipase A2 (1996) (1)
- Distinct genetic subsets in ANCA-associated vasculitis. (2012) (1)
- PROINFLAMMATORY CYTOKINES AND ELASTASE- (cid:97) -1-ANTITRYPSIN IN ARGENTINE HEMORRHAGIC FEVER (1999) (0)
- using a baboon model. neutrophilic proteinases in sepsis: studies inhibitor of fibrinolytic, clotting, and Alpha-2-macroglobulin functions as an (2013) (0)
- fibrinolytic and cytokine response Tissue factor pathway inhibitor dose-dependently inhibits coagulation (2000) (0)
- Amyloid P Component to Apoptotic Cells Chromatin-Independent Binding of Serum (2001) (0)
- Extended studies on the pathophysiology of dengue haemorrhagic fever; studies on haemostasis, immunology, virology and genetic markers aimed at developing intervention strategies (2000) (0)
- UvA-DARE ( Digital Academic Repository ) A new principle for rapid immunoassay of proteins based on in situ precipate-enhanced ellipsometry (1999) (0)
- [Serine protease inhibitors (serpins); regulators of coagulation and inflammation reactions with therapeutic potential]. (1990) (0)
- Gp91 phox-homologs in cardiomyocytes: a putative novel source of reactive oxygen species. Molecular and functional characterization in rat and human cardiomyocytes (2002) (0)
- British Medical Journal (1899) (0)
- Human IAPP is a contributor to painful diabetic peripheral neuropathy (2021) (0)
- Responses In Vitro and In Vivo Detection of Native Species During CTL Extracellular Granzymes A and B in Humans : (1998) (0)
- against inactivation by protease inhibitors Extracellular granzyme A, complexed to proteoglycans, is protected (2013) (0)
- Predictive value of cytokines and clinical factors in patients with fever (1994) (0)
- ReceptorsBinding to B Cells: A Role for Complement Antibody Complex Formation and - Allergen IgG Antibodies in Food Allergy Influence (2013) (0)
- Markers of Microbial Infection (2004) (0)
- CORRIGENDUM (2006) (0)
- P3-099: Serum Amyloid P component as biomarker in Alzheimer's disease (2008) (0)
- CHAPTER 4 INTERLEUKIN-6 , FEVER AND ACUTE PHASE RESPONSES IN PATIENTS WITH BURNS (2001) (0)
- DEMONSTRATION OF Cl-INHIBITOR COMPLEXES IN PLASMA BY HIGHLY SENSITIVE RADIOIMMUNOASSAYS USING A MONOCLONAL ANTIBODY AGAINST A NEODETERMINANT ON COMPLEXED Cl-INHIBITOR (1987) (0)
- Increased systemic levels of soluble granzymes A and B during viral infection after renal transplantation (1997) (0)
- A Novel Marker for Disease Activity in Kawasaki Disease (2003) (0)
- Complement activatie op micropartikels (2007) (0)
- Human C1 esterase inhibitor; plasma protein; model of the serpin domain obtained by homology modeling (2002) (0)
- Differential expression of L-selectin in peripheral blood CD8+ granzyme B+ T cells from renal allograft recipients during acute rejection and primary viral infection (1997) (0)
- The role of the intracellular serpin PI9 in the modulation of cell death in cancer cells (2004) (0)
- Treatment of Severe Sepsis with C1-Inhibitor (1999) (0)
- Plasma Levels of Interleukin‐6 and Leukemia Inhibiting Factor in Paediatric Dengue Virus Infection ‐ A Pilot Study: 572 (1997) (0)
- UvA-DARE ( Digital Academic Repository ) Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria (2017) (0)
- Interaction between complement activation and neutrophil degranulation as related to mortality in medical patients with fever (2005) (0)
- Tissue factor pathway inhibitor does not influence inflammatory pathways during human (2001) (0)
- Monitoring of immunotherapy with cytokines or monoclonal antibodies (2004) (0)
- Relative contribution ofcontactandcomplement activation toinflammatory reactions inarthritic oints (1992) (0)
- anaplastic large cell lymphoma Expression levels of apoptosis-related proteins predict clinical outcome in (2013) (0)
- Plasminogen Activation ln Mvo upon lntravenous lnfusion of DDAVP ouantitative Assessment of Plasm in-a,2-Antiplasmin complex with a Novel Monoclonal Antibody Based Radioimmunoissay (2018) (0)
- Bacteraemia as a risk factor for septic shock in medical patients with fever (2005) (0)
- non-diagnostic ECG patients with chest pain presenting with a normal or The value of haemostatic markers in the triage of (2006) (0)
- Evaluation of the Organon Teknika Plasmapur system with new software and two types of filter. (1991) (0)
- Shock II (2011) (0)
- Behaviour of human C1-inhibitor potentiated with DXS in a rat model (1998) (0)
- An In Silico Model of Endotoxic Shock Mediators (Briefing Charts) (2012) (0)
- pneumoniain the lung during ventilator associated Local activation of coagulation and inhibition of (2006) (0)
- UvA-DARE ( Digital Academic Repository ) Assessment of complement activation in human disease (2008) (0)
- Implications for Granule-Mediated Apoptosis B-Glycosaminoglycan Complexes: Apoptosis Induced by Granzyme (2013) (0)
- A novel 3D model of C1-inhibitor based on the crystal structure of 4 intact serpins (2000) (0)
- The coagulant and inflammatory properties of phospholipid microparticles generated in vivo (2001) (0)
- UvA-DARE ( Digital Academic Repository ) In vivo signal transduction : mitogen activated protein kinases in inflammation (2007) (0)
- C1-inhibitor in the vascular leak syndrome (author's reply) (1994) (0)
- in patients with rheumatoid arthritis Infliximab treatment reduces complement activation (2006) (0)
- Pharmacokinetics of Cl-inhibitor protein in patients with acute myocardial infarction (2006) (0)
- Impaired plasma protein synthesis after major liver resection leads to activation of coagulation and fibrinolysis: the effect of bactericidal/permeability-increasing protein (1999) (0)
- Immune-Privileged Sites DendriticInhibitor 9 , Is Mainly Expressed by The Granzyme B Inhibitor , Protease (2001) (0)
- Inhibitory Activity of C 4 b-Binding Protein C-Reactive Protein : Targeting of the Regulation of Complement Activation by McGrath , (2006) (0)
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