Charles E. Inturrisi
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(Suggest an Edit or Addition)Charles E. Inturrisi's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions (1990) (579)
- Clinical Pharmacology of Opioids for Pain (2002) (520)
- Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite. (1989) (384)
- Central nervous system excitatory effects of meperidine in cancer patients (1983) (379)
- Morphine-6-glucuronide, a potent mu agonist. (1987) (376)
- Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. (1977) (346)
- The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord (1997) (326)
- The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-l-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids (1994) (274)
- National Institutes of Health Consensus Development Conference statement: hydroxyurea treatment for sickle cell disease. (2008) (269)
- Sublingual absorption of selected opioid analgesics (1988) (264)
- Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain (1987) (250)
- The Pharmacokinetics of Heroin in Patients with Chronic Pain (1984) (232)
- d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia. (1999) (230)
- Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614. (1993) (226)
- Methadone safety: a clinical practice guideline from the American Pain Society and College on Problems of Drug Dependence, in collaboration with the Heart Rhythm Society. (2014) (199)
- Evidence from opiate binding studies that heroin acts through its metabolites. (1983) (198)
- A Conditional Deletion of the NR1 Subunit of the NMDA Receptor in Adult Spinal Cord Dorsal Horn Reduces NMDA Currents and Injury-Induced Pain (2003) (177)
- β-Endorphin: Analgesic and hormonal effects in humans (1979) (170)
- Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base. (2010) (168)
- Transdermal Fentanyl for Cancer Pain Repeated Dose Pharmacokinetics (1993) (161)
- Morphine-6-glucuronide concentrations and opioid-related side effects: a survey in cancer patients (1995) (157)
- The levels of methadone in the plasma in methadone maintenance (1972) (150)
- Disposition of methadone in man after a single oral dose (1972) (141)
- Ketamine Attenuates and Reverses Morphine Tolerance in Rodents (1996) (136)
- Treatment of opioid‐induced constipation with oral naloxone: A pilot study (1992) (134)
- The metabolite morphine‐6‐glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function (1992) (133)
- Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat. (1994) (132)
- Dextromethorphan attenuates and reverses analgesic tolerance to morphine (1994) (126)
- An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in mice (1996) (125)
- Chronic nausea and morphine-6-glucuronide. (1991) (124)
- Plasma morphine and morphine-6-glucuronide during chronic morphine therapy for cancer pain: plasma profiles, steady-state concentrations and the consequences of renal failure (1991) (122)
- Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice. (1981) (122)
- N-Methyl-D-Aspartate (NMDA) Receptors, Mu and Kappa Opioid Tolerance, and Perspectives on New Analgesic Drug Development (1995) (122)
- Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice (1996) (121)
- Spinal gabapentin is antinociceptive in the rat formalin test (1997) (121)
- Influence of Naloxone Infusion on Analgesia and Respiratory Depression Following Epidural Morphine (1986) (117)
- Nitric oxide and opioid tolerance (1994) (116)
- Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation (1992) (113)
- Methadone assays in pregnant women and progeny. (1975) (111)
- Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test (1997) (109)
- Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. (2013) (106)
- Pharmacology of methadone and its isomers. (2005) (106)
- Pharmacokinetic‐pharmacodynamic relationships of methadone infusions in patients with cancer pain (1990) (103)
- Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain (1995) (101)
- Treatment of opioid-induced constipation with oral naloxone: a pilot study. (1993) (99)
- Estrogen regulation of mu-opioid receptor mRNA in the forebrain of female rats. (1997) (97)
- Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat. (1985) (96)
- I.v. infusion of opioids for cancer pain: clinical review and guidelines for use. (1986) (95)
- Analgesic drug therapy in cancer pain: principles and practice. (1987) (95)
- Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine (1999) (94)
- Estradiol replacement in ovariectomized rats is antihyperalgesic in the formalin test. (2007) (94)
- Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes. (1994) (93)
- Improving the pharmacologic management of pain in older adults: identifying the research gaps and methods to address them. (2011) (90)
- Estradiol and progesterone differentially regulate formalin-induced nociception in ovariectomized female rats (2006) (85)
- Epidural and intrathecal opiates: Cerebrospinal fluid and plasma profiles in patients with chronic cancer pain (1985) (85)
- Transdermal fentanyl in children with cancer pain: feasibility, tolerability, and pharmacokinetic correlates. (1999) (83)
- A gas-liquid chromatographic method for the quantitative determination of methadone in human plasma and urine. (1972) (80)
- d-Methadone is antinociceptive in the rat formalin test. (1997) (79)
- Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA (1995) (77)
- Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. (1980) (77)
- The analgesic efficacy of intrathecal d-ala2-d-leu5-enkephalin in cancer patients with chronic pain (1985) (76)
- Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment. (1985) (75)
- Cav1.2 L-Type Ca2+ Channels Mediate Cocaine-Induced GluA1 Trafficking in the Nucleus Accumbens, a Long-Term Adaptation Dependent on Ventral Tegmental Area Cav1.3 Channels (2011) (74)
- Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse. (1986) (73)
- Disposition of acetylmethadol in relation to pharmacologic action (1975) (72)
- Consensus guideline on parenteral methadone use in pain and palliative care (2008) (67)
- CSF distribution of morphine, methadone and sucrose after intrathecal injection. (1985) (67)
- Glucocorticoid regulation of enkephalins in cultured rat adrenal medulla. (1988) (66)
- Morphine-induced immunomodulation is not related to serum morphine concentrations. (1988) (65)
- Chronic morphine therapy for cancer pain (1991) (65)
- Pharmacokinetics and pharmacodynamics of subcutaneous naltrexone pellets in the rat. (1986) (65)
- Pharmacokinetics and effects of 17beta-estradiol and progesterone implants in ovariectomized rats. (2005) (63)
- The effects of LY293558, an AMPA receptor antagonist, on acute and chronic morphine dependence (1997) (63)
- Propoxyphene and norpropoxyphene kinetics after single and repeated doses of propoxyphene (1982) (63)
- N-Methyl-d-aspartate receptor (NMDAR) independent maintenance of inflammatory pain (2010) (61)
- Methadone: radioimmunoassay and pharmacokinetics in the rat. (1981) (61)
- The simultaneous determination of propoxyphene and norpropoxyphene in human biofluids using gas-liquid chromatography. (1973) (59)
- Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE. (1988) (59)
- Activation of the Neuronal Extracellular Signal-Regulated Kinase 2 in the Spinal Cord Dorsal Horn Is Required for Complete Freund's Adjuvant-Induced Pain Hypersensitivity (2008) (59)
- Preclinical Evidence for a Role of Glutamatergic Systems in Opioid Tolerance and Dependence (1997) (58)
- The competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist LY293558 attenuates and reverses analgesic tolerance to morphine but not to delta or kappa opioids. (1997) (57)
- CNS levels of mu opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone (1995) (57)
- Disposition of propoxyphene and norpropoxyphene in man after a single oral dose (1974) (56)
- Plasma immunoreactive beta-endorphin levels in depression. Effect of electroconvulsive therapy. (1983) (54)
- Stabilization of the μ-Opioid Receptor by Truncated Single Transmembrane Splice Variants through a Chaperone-like Action* (2013) (54)
- Analgesia Produced by a Spinal Action of Morphine and Effects upon Parturition in the Rat (1979) (54)
- An Antisense Oligonucleotide to the N-Methyl-d-aspartate (NMDA) Subunit NMDAR1 Attenuates NMDA-Induced Nociception, Hyperalgesia, and Morphine Tolerance (2005) (51)
- Constraints on the tailflick assay: morphine analgesia and tolerance are dependent upon locus of tail stimulation. (1984) (51)
- Quantitation of NMDA receptor (NMDAR1) mRNA levels in the adult and developing rat CNS. (1993) (51)
- Meperidine pharmacokinetics in the maternal-fetal unit. (1978) (50)
- Management of cancer pain. Pharmacology and principles of management (1989) (49)
- Chronic vascular catheterization in the rat: Comparison of three techniques (1984) (49)
- Time course of enkephalin mRNA and peptides in cultured rat adrenal medulla. (1992) (48)
- Stereospecific synthesis of the 6beta-hydroxy metabolites of naltrexone and naloxone. (1975) (46)
- NMDA antagonists and clonidine block c‐fos expression during morphine withdrawal (1995) (44)
- siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats. (2009) (44)
- The role of N-methyl-D-aspartate (NMDA) receptors in pain and morphine tolerance. (2005) (43)
- Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-d-aspartate receptor in spinal cord dorsal horn (2008) (43)
- Antisense Oligodeoxynucleotides to the Cloned δ Receptor DOR‐1: Uptake, Stability, and Regulation of Gene Expression (1995) (41)
- Thallium activation of K+-activated phosphatases from beef brain. (1969) (40)
- Design and Evaluation of Small Interfering RNAs That Target Expression of the N-Methyl-d-aspartate Receptor NR1 Subunit Gene in the Spinal Cord Dorsal Horn (2007) (39)
- β‐ENDORPHIN IMMUNOREACTIVITY IN THE PLASMA OF PSYCHIATRIC PATIENTS RECEIVING ELECTROCONVULSIVE TREATMENT * (1982) (38)
- Effects of eight-hour naloxone infusions on human subjects. (1983) (38)
- Kinetics of oligomycin inhibition of sodium- and potassium-activated adenosine triphosphatase from beef brain. (1968) (36)
- Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment. (1988) (36)
- Opioid receptor upregulation and supersensitivity in mice: Effect of morphine sensitivity (1989) (36)
- Antinociceptive activity and toxicity of meperidine and normeperidine in mice. (1982) (35)
- Preproenkephalin mRNA and enkephalin in normal and denervated adrenals in the Syrian hamster: comparison with central nervous system tissues. (1991) (35)
- Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia (1999) (34)
- Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614. (2003) (34)
- Determination of heroin and its metabolites by high-performance liquid chromatography. (1982) (34)
- Conditional deletion of the NMDA-NR1 receptor subunit gene in the central nucleus of the amygdala inhibits naloxone-induced conditioned place aversion in morphine-dependent mice (2008) (33)
- Role of opioid analgesics. (1984) (33)
- Effects of acetylmethadol on plasma testosterone (1976) (32)
- Opioid analgesics in the management of clinical pain (1986) (32)
- An improved method detects differential NGF and BDNF gene expression in response to depolarization in cultured hippocampal neurons. (1994) (31)
- Clinical Research: Analgesia and Morphine Disposition in Burn Patients (1983) (31)
- Ethanol and naloxone differentially upregulate delta opioid receptor gene expression in neuroblastoma hybrid (NG108-15) cells. (1994) (30)
- Narcotic Antagonist Activity of Several Metabolites of Naloxone and Naltrexone Tested in Morphine Dependent Mice 1 (1975) (30)
- Regulation of rat adrenal medullary enkephalins by glucocorticoids. (1987) (30)
- Narcotic Drugs (1931) (29)
- Ouabain-dependent incorporation of 32P from p-nitrophenyl phosphate into a microsomal phosphatase. (1970) (29)
- Chronic opioid exposure produces increased heroin self-administration in rats (2003) (28)
- Acute and Persistent Suppression of Preproenkephalin mRNA Expression in the Striatum Following Developmental Hypoxic‐Ischemic Injury (1994) (28)
- High‐dose naloxone: Pharmacokinetics in patients in septic shock (1987) (28)
- The effect of the irreversible mu-opioid receptor antagonist clocinnamox on morphine potency, receptor binding and receptor mRNA. (1995) (28)
- Heroin: analgesia, toxicity and disposition in the mouse. (1982) (27)
- Isolation and stereochemical identification of a metabolite of naltrexone from human urine. (1974) (27)
- Thallium-induced dephosphorylation of a phosphorylated intermediate of the (sodium plus thallium-activated) ATPase. (1969) (27)
- Cerebrospinal fluid pharmacokinetics of intrathecal morphine sulfate and D‐Ala2‐D‐Leu5‐enkephalin (1986) (27)
- beta-Endorphin: analgesic and hormonal effects in humans. (1979) (27)
- DISPOSITION OF NARCOTICS AND NARCOTIC ANTAGONISTS * (1976) (27)
- Effect of pregnancy and pain on cerebrospinal fluid immunoreactive enkephalins and norepinephrine in healthy humans (1990) (26)
- NIH consensus development statement on hydroxyurea treatment for sickle cell disease. (2008) (26)
- REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial. (2021) (26)
- The urinary excretion profiles of naltrexone in man, monkey, rabbit, and rat. (1976) (26)
- Studies on the antidiuretic action of morphine in the rat. (1968) (25)
- Levorphanol: pharmacokinetics and steady-state plasma concentrations in patients with pain. (1983) (25)
- Naloxone radioimmunoassay: an improved antiserum (1983) (25)
- Quantitation of mu-opioid receptor (MOR-1) mRNA in selected regions of the rat CNS. (1995) (25)
- Cerebrospinal fluid distribution of opioids after intraventricular & lumbar subarachnoid administration in sheep. (1996) (24)
- Methadyl acetate (LAAM) in the treatment of heroin addicts. II. Double-blind comparison of gradual and abrupt detoxification. (1983) (24)
- Methadone induced physical dependence in the rat. (1984) (24)
- Retinoic acid regulation of mu opioid receptor and c-fos mRNAs and AP-1 DNA binding in SH-SY5Y neuroblastoma cells. (2002) (23)
- Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment (1995) (23)
- Retinoic acid-induced increase in delta-opioid receptor and N-Methyl-d-Aspartate receptor mRNA levels in neuroblastoma × glioma (NG108-15) cells (1996) (23)
- Quantitative distribution of the delta opioid receptor mRNA in the mouse and rat CNS. (1995) (23)
- Disposition of methadone in the ovine maternal-fetal unit. (1981) (22)
- Simultaneous determination of meperidine and normeperidine in biofluids. (1976) (21)
- Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance (1995) (21)
- Cloning and characterization of hamster proenkephalin gene. (1994) (21)
- The tubular transport and metabolism of morphine-N-methyl-C14 by the chicken kidney. (1967) (21)
- Simultaneous determination of acetylmethadol and its active riotransformation products in human biofluids. (1975) (21)
- A chronic sheep preparation for the study of drug pharmacokinetics in spinal and ventricular CSF. (1986) (20)
- Patient-Reported Outcomes and Opioid Use by Outpatient Cancer Patients. (2017) (20)
- Chronic opioid antagonist treatment facilatates nonopioid, stress-induced analgesia (1987) (20)
- A gas-liquid chromatographic method for the quantitative determination of acetylmethadol and its metabolites in human urine. (1973) (19)
- Inducible expression of N-methyl-d-aspartate receptor, and delta and mu opioid receptor messenger RNAs and protein in the NT2-N human cell line (1997) (19)
- Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. (2008) (19)
- OUABAIN SENSITIVITY OF THE Na+, K+‐ATPase FROM RAT NEONATAL AND HUMAN FETAL AND ADULT HEART * (1974) (19)
- Attenuation of Acute Morphine Withdrawal in the Neonatal Rat by the Competitive NMDA Receptor Antagonist LY235959 (2002) (19)
- Oral ketamine produces a dose-dependent CNS depression in the rat. (1996) (19)
- Deletion of the Glutamate Receptor 5 Subunit of Kainate Receptors Affects the Development of Morphine Tolerance (2009) (18)
- Metrazole induces the sequential activation of c-fos, proenkephalin, and tyrosine hydroxylase gene expression in the rat adrenal gland: modulation by glucocorticoid and adrenocorticotropic hormone. (1993) (18)
- The graded and quantal nature of opioid analgesia in the rat tailflick assay (1985) (18)
- Attenuation of hyperalgesia by LY235959, a competitive N-methyl-d-aspartate receptor antagonist (2001) (18)
- Urinary excretion of meperidine by the fetal lamb. (1979) (18)
- Characterization of the Safety and Pharmacokinetic Profile of D-Methadone, a Novel N-Methyl-D-Aspartate Receptor Antagonist in Healthy, Opioid-Naive Subjects: Results of Two Phase 1 Studies (2019) (17)
- Metrazole induction of c-fos and proenkephalin gene expression in the rat adrenal and hippocampus: pharmacological characterization. (1993) (17)
- The contribution of MOR-1 exons 1–4 to morphine and heroin analgesia and dependence (2009) (17)
- Characterization of enkephalins in rat adrenal medullary explants (1988) (17)
- Pain Assessment, Management, and Control Among Patients 65 Years or Older Receiving Hospice Care in the U.S. (2016) (17)
- Naltrexone Maintenance: Effect on Morphine Sensitivity in Normal Volunteers. (1993) (17)
- Transsynaptic activity regulates proenkephalin and tyrosine hydroxylase gene expression and the response to reserpine in the hamster adrenal. (1991) (16)
- A survey of acute and chronic heroin dependence in ten inbred mouse strains: Evidence of genetic correlation with morphine dependence (2008) (16)
- The successful use of parenteral methadone in a patient with a prolonged QTc interval. (2007) (15)
- Amniotic Fluid Transfer of Meperidine From Maternal Plasma in Early Pregnancy (1978) (15)
- Parenteral methadone: an essential medication for the treatment of pain. (2003) (15)
- Estradiol‐induced antinociceptive responses on formalin‐induced nociception are independent of COX and HPA activation (2011) (15)
- Perioperative pain management in the opioid-tolerant individual. (2008) (14)
- The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats. (2020) (14)
- Amniotic fluid methadone in women maintained on methadone. (1974) (13)
- Section Review Central & Peripheral Nervous Systems Pharmacological modulation of opioid tolerance (1995) (13)
- Renal tubular secretion of meperidine by the fetal lamb. (1980) (13)
- MU OPIOID RECEPTOR (MOR-1) mRNA LEVELS ARE ALTERED IN MICE WITH DIFFERENTIAL ANALGESIC SENSITIVITY TO THE MU AGONIST DAMGO (1995) (13)
- Differences in delta opioid receptor antinociception, binding, and mRNA levels between BALB/c and CXBK mice (1998) (13)
- The clinically available NMDA receptor antagonist dextromethorphan attenuates acute morphine withdrawal in the neonatal rat. (2003) (12)
- REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study (2021) (12)
- Proenkephalin gene expression: interaction of glucocorticoid and cAMP regulatory elements. (1995) (12)
- Feeling pain? Who's your daddy... (2006) (10)
- Dynorphin A(1–13) Analgesia in Opioid-Treated Patients with Chronic Pain (1999) (10)
- Activation of protein kinase A prevents the ethanol-induced up-regulation of δ-opioid receptor mRNA in NG108-15 cells (1997) (10)
- Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions. (1993) (10)
- Acute morphine dependence in mice selectively-bred for high and low analgesia (1998) (10)
- Brain uptake of meperidine in the fetal lamb. (1980) (10)
- Interactions of estradiol and NSAIDS on carrageenan-induced hyperalgesia (2011) (9)
- Chronic naltrexone differentially affects supraspinal δ-opioid receptor-mediated antinociception (1998) (9)
- Disposition of narcotics in patients with renal disease. (1977) (9)
- MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats. (2003) (8)
- Strain differences in the analgesic potency of morphine and in mu opioid receptor mRNA levels in adult male mice (1994) (8)
- Patient-Reported Outcomes and Opioid Use in Outpatients With Chronic Pain. (2017) (8)
- Effect of supraspinal antisense oligodeoxynucleotide treatment on delta-opioid receptor mRNA levels in mice. (1997) (7)
- Retinoic acid-induced increase in delta-opioid receptor and N-methyl-D-aspartate receptor mRNA levels in neuroblastoma x glioma (NG108-15) cells. (1996) (7)
- A true believer's flawed analysis. (2011) (7)
- Using Chronic Pain Outcomes Data to Improve Outcomes. (2016) (7)
- Induction of Tyrosine Hydroxylase mRNA by Protein Synthesis Inhibitors in the Rat Adrenal (1993) (6)
- The diuretic effect of morphine in the chicken. (1968) (6)
- Combined seminar on the use of drugs in renal failure: narcotics, psychotherapeutic agents, antiarrhythmics, antihypertensives, sorbents, vitamin D and its analogues, anabolic hormones and nutritional supplements. (1977) (6)
- Dextromethorphan attenuates and reverses morphine tolerance (1993) (6)
- The quantitation of methadone in human amniotic fluid. (1973) (6)
- Reduction of 6-ketones of the morphine series with formamidinesulfinic acid. Stereoselectivity opposite to that of hydride reductions. (1976) (6)
- Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1). (1997) (6)
- The antidiuretic effect of narcotic analgesics in the mouse. (1968) (5)
- Pharmacokinetic-pharmacodynamic (PK-PD) relationships of methadone and hydromorphone infusions in pain patients (1987) (5)
- Successful use of buprenorphine-naloxone medication-assisted program to treat concurrent pain and opioid addiction after cancer therapy. (2020) (5)
- Upregulation of delta opioid receptor gene expression in NG108-15 cells by naloxone and ethanol (1994) (5)
- The development of tolerance to the antidiuretic effect of morphine in the mouse. (1968) (5)
- Epidural opiates: plasma and cerebrospinal fluid (CSF) pharmacokinetics of morphine, methadone and beta-endorphin (1981) (5)
- Determination of acetylmethadol and metabolites by use of high-performance liquid chromatography. (1981) (5)
- The Tri-Institutional Pain Registry—Analysis of Outpatient Pain Management at a Specialized Cancer Center (2017) (5)
- Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5 (2010) (5)
- The quantitation of cyclazocine and its metabolites in human urine by use of gas-liquid chromatography. (1974) (5)
- Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors (2022) (5)
- Synthesis of alpha-1-noracetylmethadol. A facile N-demethylation of alpha-1-acetylmethadol. (1975) (4)
- Response to the letters to the editor by Dr. Du Pen and Ms. A. Williams and by Drs. Arnér and Meyerson (1991) (4)
- STEREOSPECIFIC SYNTHESIS OF THE 6BETA-HYDROXY METABOLITES OF NALTREXONE AND NALOXONE (1975) (4)
- Levorphanol:radioimmunoassay and plasma concentration profiles in dog and man. (1980) (4)
- Disposition and effects of intravenous (iv) methadone (met) in cancer patients (1981) (4)
- Levels of Delta-Opioid Receptor mRNA in Morphine-Tolerant Mice (1995) (4)
- REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats (2022) (3)
- The effect of obesity on pain severity and pain interference. (2021) (3)
- Chronic naltrexone differentially affects supraspinal delta-opioid receptor-mediated antinociception. (1998) (3)
- A correction on the reduction of dihydrocodeinone with formamidinesulfinic acid. Stereoselective reduction of dihydropseudocodeinone (1978) (3)
- Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling (2022) (3)
- Diagnosing Prescription Opioid Use Disorder in Patients Using Prescribed Opioids for Chronic Pain. (2022) (3)
- The Effect of Obesity on Pain Severity and Pain Interference (2020) (3)
- The analgesic efficacy of intrathecal (it) D-Ala2-D-Leu5 enkephalin (DADL) in cancer patients with chronic pain (1984) (3)
- Activation of protein kinase A prevents the ethanol-induced up-regulation of delta-opioid receptor mRNA in NG108-15 cells. (1997) (3)
- A comparison of the effects of a macrobiotic diet and a western diet on drug metabolism and plasma lipids in man (2004) (2)
- Separation of Radiolabeled Acetylmethadol and Metabolites by Thin-Layer Chromatography (1977) (2)
- The N-Methyl-D-Aspartate Receptor (NMDAR) and neuronal-glial-cytokine interactions that initiate and maintain inflammatory pain (2009) (2)
- Old dogs, new tricks (1999) (2)
- Esmethadone (REL-1017) Reduces Glutamate-Induced Currents in NMDA Receptors With the GluN2D Subunit (2021) (2)
- Comment on “Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status“ (2022) (2)
- Disposition and effects of heroin in pain patients (1984) (2)
- Esmethadone (REL-1017) Compares With NMDA Receptor Antagonists in FLIPR-Ca2+ Assay (2021) (2)
- The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin (2022) (2)
- Does transdermal fentanyl work in patients with low BMI? Patient‐reported outcomes of pain and percent pain relief in cancer patients on transdermal fentanyl (2019) (2)
- Levorphanol: a simplified radioimmunoassay for clinical use. (1981) (2)
- Effects of Levorphanol and Levallorphan on Osmolality of Serum from Water Loaded Rats.∗ (1963) (2)
- An anomalous reaction of methadone with chloroformate esters. (1973) (2)
- INTRATHECAL BETA-ENDORPHIN (1980) (2)
- REDUCTION OF 6-KETONES OF THE MORPHINE SERIES WITH FORMAMIDINESULFINIC ACID. STEREOSELECTIVITY OPPOSITE TO THAT OF HYDRIDE REDUCTIONS (1977) (2)
- Esmethadone (REL-1017) Shows Similar Effects to Ketamine in Manual Patch Clamp Studies (2021) (1)
- Adrenal enkephalin biosynthesis regulated by glucocorticoid. (1988) (1)
- 137) Cellular localization of inflammatory pain signaling in spinal cord dorsal horn (2008) (1)
- Erratum: Consensus guideline on parental methadone use in pain and palliative care (Palliative and Supportive Care (2008) vol. 6 (2) (165-176) 10.1017/S1478951508000254) (2008) (1)
- (452) The influence of age and gender on opioid dosage in chronic noncancer pain clinic patients. (2016) (1)
- Esmethadone (REL-1017) Restores NMDA Receptor 1 Subunit Expression in an In Vitro Model of Glutamatergic Excitotoxicity (2021) (1)
- Investigation of opiate pharmacokinetics in an animal model (1984) (1)
- Cancer Pain: Pharmacology of analgesia: basic principles (2003) (1)
- Association of severe pain with poor response to opioids, psychological distress, and aberrant drug taking behaviors in a large cohort of cancer patients. (2015) (1)
- Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference (2010) (1)
- Species Dependent Accumulation of Morphine-6-Glucuronide (M-6-G) After Morphine (MOR) Administration (1991) (1)
- 2558 – FETAL ELIMINATION OF MEPERIDINE (1978) (1)
- Beta-endorphin immunoreactivity in the plasma of patients with the Prader-Labhart-Willi syndrome and their normal siblings (1983) (1)
- Methadone pharmacokinetics in the rat (1979) (1)
- Tribute to Mitchell B. Max, 1949-2008 (2009) (1)
- 193) Concurrent use of ketamine and methadone in severe cancer pain (2008) (1)
- Dr. Ray Houde (1916–2006) (2006) (0)
- Effects of MK801 on cocaine induction of c - Fos and preprodynorphin mRNAs and AP - 1 DNA binding in Fischer rats (2003) (0)
- Disposition of acetylmethadol in relation to pharmacological activity. 1975 [proceedings]. (1976) (0)
- (194) Transfusion-induced opioid requirements: Results of a first clinical study and its consequences (2008) (0)
- Molecular Modulation of In Vivo Tolerance (2011) (0)
- Pharmacokinetics and Pharmacodynamics of Selected Opioids (2007) (0)
- Factors affecting the synthesis and release of opioid peptides (1987) (0)
- ANTINOCICEPTIVE AND TOXIC ACTIVITIES OF INTRACEREBROVENTRICULARLY (ICV) ADMINISTERED MORPHINE (M), 6-ACETYLMORPHINE (AM) AND 3,6-DIACETYLMORPHINE (DAM) IN MICE (1981) (0)
- Guest reviewers (1994) (0)
- Symposium for 20th anniversary celebration of NIDA: Update on opioid receptor cloning: Implications for research on addiction (1995) (0)
- AN ANOMALOUS REACTION OF METHADONE WITH CHLOROFORMATE ESTERS (1974) (0)
- Cav1.3 L-type Ca2+ channel-activated CaMKII/ERK2 pathway in the ventral tegmental area is required for cocaine conditioned place preference (2022) (0)
- Variants through a Chaperone-like Action Truncated Single Transmembrane Splice-Opioid Receptor by μ Stabilization of the Molecular Bases of Disease : (2013) (0)
- SYNTHESIS OF ALPHA-1-NORACETYLMETHADOL, A FACILE N-DEMETHYLATION OF ALPHA-1-ACETYLMETHADOL (1975) (0)
- Design of a prospective comparative effectiveness research model for interventions used in chronic pain management (2011) (0)
- Bioavailability of heroin in cancer patients after repeated oral dosing (1988) (0)
- METHADONE AND HYDROMORPHONE INFUSIONS IN PAIN PATIENTS. (1988) (0)
- Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak (2021) (0)
- (657): N-Methyl-D-Aspartate receptor dependent and independent signaling pathways in the spinal cord mediate inflammatory pain (2006) (0)
- Consensus guideline on parental methadone use in pain and palliative care (2008) (0)
- [d-Ala2]Deltorphin II induced tolerance does not alter delta opioid receptor (DOR) mRNA levels in mouse CNS (1994) (0)
- Simultaneous determination of acetyl-methadol and its active biotransformation products in human biofluids. 1975 [proceedings]. (1976) (0)
- Methadone pharmacokinetics in the rat: S.C. and I.P. administration (1980) (0)
- (D) -methadone a non-opioid analgesic. (1998) (0)
- EFFECTS OF K1-OPIOID TOLERANCE ON CNS NMDAR1 mRNA EXPRESSION (1995) (0)
- Esmethadone-HCl (REL-1017): a promising rapid antidepressant. (2023) (0)
- (386) The influence of age and gender on opioid dosage in cancer pain clinic patients. (2016) (0)
- Esmethadone (REL-1017) Antagonizes NMDA Receptors and Reduces Ca2+ Entry in Presence of Quinolinic Acid and Gentamicin (2021) (0)
- 242) Marked and sustained reduction of opioid requirements after administration of intravenous naloxone for respiratory depression (2008) (0)
- Postsynaptic NMDA receptors in the lumbar spinal cord dorsal horn are required for inflammatory pain (2003) (0)
- /3-Endorphin: Analgesic and hormonal effects in humans (metabolic clearance hormone/enkephalin analog/baboons) (0)
- CSF distribution of opioids after intracerebroventricular (ICV) and lumbar intrathecal (I.T.) administration in the sheep (1987) (0)
- Differential regulation of c-fos, proenkephalin and tyrosine hydroxylase gene expression by metrazole in the hamster adrenal and hippocampus (1995) (0)
- D-propoxyphene: Accumulation or altered kinetics? (2004) (0)
- Methadone suppositories (MS) for the treatment of cancer pain (1993) (0)
- 1147 – RELATIONSHIPS BETWEEN DISPOSITIONAL FACTORS AND RESPONSE TO NARCOTIC ANALGESICS (1978) (0)
- CHAPTER 17 – Characterization of Pain Receptors in the Spinal Cord Using a Viral Vector for Spatial–Temporal Gene Targeting (2006) (0)
- (650/Paper 312): Small interfering RNAs-(siRNAs) that target expression of the NMDAR1 subunit gene in the spinal cord dorsal horn prevent inflammatory allodynia (2007) (0)
- Physical dependence to methadone and morphine in the rat (1982) (0)
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What Schools Are Affiliated With Charles E. Inturrisi?
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