C. Peter Downes
#125,444
Most Influential Person Now
C. Peter Downes's AcademicInfluence.com Rankings
C. Peter Downesbiology Degrees
Biology
#7902
World Rank
#10894
Historical Rank
Molecular Biology
#953
World Rank
#976
Historical Rank
Biochemistry
#1111
World Rank
#1228
Historical Rank
Download Badge
Biology
C. Peter Downes's Degrees
- PhD Biochemistry University of California, San Francisco
- Bachelors Chemistry University of California, Berkeley
Why Is C. Peter Downes Influential?
(Suggest an Edit or Addition)C. Peter Downes's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα (1997) (2859)
- Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. (1982) (1983)
- Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. (1983) (1656)
- The lipid phosphatase activity of PTEN is critical for its tumor supressor function. (1998) (1208)
- The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins (2004) (1121)
- Neural and developmental actions of lithium: A unifying hypothesis (1989) (999)
- Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate (1988) (934)
- Redox regulation of PI 3‐kinase signalling via inactivation of PTEN (2003) (596)
- Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (2000) (567)
- A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation (2002) (477)
- PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 (1999) (446)
- The polyphosphoinositide phosphodiesterase of erythrocyte membranes. (1981) (436)
- PTEN function: how normal cells control it and tumour cells lose it. (2004) (431)
- Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. (1983) (406)
- PTEN: The down side of PI 3-kinase signalling. (2002) (399)
- Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN (2001) (378)
- The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions. (1981) (370)
- The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane. (1982) (359)
- Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. (2002) (358)
- Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. (1999) (352)
- Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands. (1985) (327)
- Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. (1996) (323)
- Understanding PTEN regulation: PIP2, polarity and protein stability (2008) (230)
- Ceramide impairs the insulin-dependent membrane recruitment of Protein Kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells (2001) (223)
- Probing phosphoinositide functions in signaling and membrane trafficking. (2005) (222)
- The role of PI 3-kinase in insulin action. (1998) (217)
- Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue (1997) (212)
- Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. (1986) (208)
- Inositol trisphosphates in carbachol-stimulated rat parotid glands. (1984) (207)
- myo-inositol metabolites as cellular signals. (1990) (200)
- dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 (2002) (197)
- The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo. (1999) (194)
- PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration (2007) (192)
- Ca2+/Calmodulin-dependent Protein Kinase II Regulates Tiam1 by Reversible Protein Phosphorylation* (1999) (179)
- Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. (1989) (173)
- Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus. (1983) (173)
- Small Molecule Antagonists of the σ-1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growth in Vitro and in Vivo (2004) (170)
- PTEN is destabilized by phosphorylation on Thr366. (2007) (163)
- Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands. (1983) (162)
- The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. (2004) (160)
- Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS (1984) (160)
- Phosphoinositide 3-kinase: a new effector in signal transduction? (1991) (154)
- Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function. (1981) (151)
- Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line* (2000) (150)
- Catalytic Domain of Phosphoinositide-specific Phospholipase C (PLC) (1998) (146)
- Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate. (1986) (146)
- Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells. (1995) (144)
- TPIP: a novel phosphoinositide 3-phosphatase. (2001) (140)
- Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression (2006) (140)
- A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets* (1998) (139)
- The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission (2001) (137)
- A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. (1994) (133)
- Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. (1992) (133)
- Distinct Phosphatidylinositol 3-Kinase Lipid Products Accumulate upon Oxidative and Osmotic Stress and Lead to Different Cellular Responses* (1999) (127)
- Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. (2000) (124)
- Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. (2003) (122)
- Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN (2009) (122)
- Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland. (1986) (115)
- Serotonin (5-Hydroxytryptamine), a Novel Regulator of Glucose Transport in Rat Skeletal Muscle* (1999) (114)
- Receptor coupled events in bradykinin action: rapid production of inositol phosphates and regulation of cytosolic free Ca2+ in a neural cell line. (1987) (110)
- Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices (1984) (109)
- A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β‐cells (2006) (109)
- Histamine Stimulation of Inositol 1‐Phosphate Accumulation in Lithium‐Treated Slices from Regions of Guinea Pig Brain (1984) (109)
- Differential redox regulation within the PTP superfamily. (2007) (108)
- Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. (2002) (101)
- Characterization of a Selective Inhibitor of Inositol Hexakisphosphate Kinases (2009) (96)
- DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. (1999) (90)
- Muscarinic Receptors and Hydrolysis of Inositol Phospholipids in Rat Cerebral Cortex and Parotid Gland (1985) (88)
- Biphasic Activation of PKBα/Akt In Platelets (1998) (83)
- Purification and Characterization of Gβγ-responsive Phosphoinositide 3-Kinases from Pig Platelet Cytosol* (1997) (82)
- Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. (2000) (81)
- Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover. (1988) (81)
- Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface* (2003) (77)
- Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo (2002) (76)
- Binding of Influenza A Virus NS1 Protein to the Inter-SH2 Domain of p85β Suggests a Novel Mechanism for Phosphoinositide 3-Kinase Activation* (2007) (75)
- Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate. (1989) (72)
- MyosinV controls PTEN function and neuronal cell size (2009) (72)
- Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. (1988) (71)
- Lithium and myo-inositol homeostasis. (1993) (69)
- Inositol phospholipids and neurotransmitter-receptor signalling mechanisms (1983) (68)
- Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. (2004) (68)
- Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. (2004) (67)
- Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. (1988) (66)
- The haemopoietic growth factors interleukin 3 and colony stimulating factor‐1 stimulate proliferation but do not induce inositol lipid breakdown in murine bone‐marrow‐derived macrophages. (1986) (64)
- A comparison of the binding of σ opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes (1986) (64)
- The control by Ca2+ of the polyphosphoinositide phosphodiesterase and the Ca2+-pump ATPase in human erythrocytes. (1982) (63)
- Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. (2001) (59)
- Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits. (1989) (58)
- The regulation of cell migration by PTEN. (2005) (57)
- Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. (1987) (57)
- Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. (2006) (57)
- The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells. (1994) (56)
- Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN. (2001) (56)
- A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in Vivo* (1997) (54)
- Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells. (1995) (53)
- Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. (1988) (52)
- Receptor-stimulated inositol phospholipid metabolism in the central nervous system. (1982) (52)
- Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress* (2010) (51)
- Product-precursor relationships amongst inositol polyphosphates. Incorporation of [32P]Pi into myo-inositol 1,3,4,6-tetrakisphosphate, myo-inositol 1,3,4,5-tetrakisphosphate, myo-inositol 3,4,5,6-tetrakisphosphate and myo-inositol 1,3,4,5,6-pentakisphosphate in intact avian erythrocytes. (1990) (51)
- Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps. (1995) (49)
- Histamine-induced inositol phospholipid breakdown mirrors H1-receptor density in brain. (1983) (49)
- Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. (1994) (48)
- Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1. (2004) (48)
- Phosphopleckstrin Inhibits Gβγ-activable Platelet Phosphatidylinositol-4,5-bisphosphate 3-Kinase* (1996) (47)
- Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors. (1989) (47)
- Agonist-stimulated phosphatidylinositol 4,5-bisphosphate metabolism in the nervous system (1986) (46)
- Muscarinic Receptors Mediate Phospholipase C-dependent Activation of Protein Kinase B via Ca2+, ErbB3, and Phosphoinositide 3-Kinase in 1321N1 Astrocytoma Cells* (2002) (44)
- The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2. (2007) (44)
- Association of a receptor and G-protein-regulated phospholipase C with the cytoskeleton. (1992) (43)
- Structural and mechanistic features of phospholipases C: effectors of inositol phospholipid-mediated signal transduction. (1997) (42)
- Role of Phosphatidylinositol 3-Kinase and Specific Protein Kinase B Isoforms in the Suppression of Apoptosis Mediated by the Abelson Protein-tyrosine Kinase* (2000) (42)
- A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties. (1990) (41)
- A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts. (1990) (40)
- Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. (2003) (40)
- Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN. (2007) (39)
- Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase. (1988) (38)
- Beta1-integrin and PTEN control the phosphorylation of protein kinase C. (2000) (38)
- Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species. (2004) (38)
- Involvement of Calcium Influx in Muscarinic Cholinergic Regulation of Phospholipase C in Cerebellar Granule Cells (1994) (38)
- Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling (2007) (37)
- The cellular functions of myo-inositol (1989) (37)
- Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin. (1987) (37)
- Inositol lipids in cell signalling. (1989) (36)
- Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells. (1996) (36)
- Inositol phosphates: a family of signal molecules? (1988) (35)
- Granulocyte-macrophage colony-stimulating factor can stimulate macrophage proliferation via persistent activation of Na+/H+ antiport. Evidence for two distinct roles for Na+/H+ antiport activation. (1990) (35)
- G-protein-mediated activation of turkey erythrocyte phospholipase C by beta-adrenergic and P2y-purinergic receptors. (1992) (34)
- Dependence of the activity of phospholipase C beta on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation. (1997) (34)
- Cooperation of Src Homology Domains in the Regulated Binding of Phosphatidylinositol 3-Kinase (1995) (32)
- Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate. (1998) (32)
- Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands. (1987) (32)
- PTEN M-CBR3, a Versatile and Selective Regulator of Inositol 1,3,4,5,6-Pentakisphosphate (Ins(1,3,4,5,6)P5) (2004) (30)
- Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells. (1998) (30)
- The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups. (2005) (30)
- An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes. (1989) (29)
- Phosphatidylinositol synthase and phosphatidylinositol/inositol exchange reactions in turkey erythrocyte membranes. (1991) (29)
- The Mechanism of Muscarinic Receptor‐Stimulated Phosphatidylinositol Resynthesis in 1321N1 Astrocytoma Cells and Its Inhibition by Li+ (1995) (29)
- A Screen for Novel Phosphoinositide 3-kinase Effector Proteins* (2011) (29)
- Inositol phospholipid 3-kinase is activated by cellular stress but is not required for the stress-induced activation of glucose transport in L6 rat skeletal muscle cells. (1997) (29)
- Association of a phosphatidylinositol-specific 3-kinase with a human trans-Golgi network resident protein (1997) (28)
- The lipid transfer activity of phosphatidylinositol transfer protein is sufficient to account for enhanced phospholipase C activity in turkey erythrocyte ghosts (1997) (28)
- Inositol trisphosphate metabolism in Saccharomyces cerevisiae: identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase. (1994) (28)
- Differential coupling of G‐protein‐linked receptors to Ca2+ mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture (1999) (27)
- Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN. (2007) (26)
- Interfacial hydrolysis of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate by turkey erythrocyte phospholipase C. (1994) (25)
- IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold* (2012) (25)
- MyosinV controls PTEN function and neuronal cell size (2009) (25)
- Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes (2000) (24)
- The σ1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: A possible mechanism of neuroprotective action (2010) (24)
- Total synthesis of the four stereoisomers of dihexadecanoyl phosphatidylinositol and the substrate stereospecificity of human erythrocyte membrane phosphatidylinositol 4-kinase. (1990) (24)
- Redox regulation of phosphatase function. (2004) (23)
- Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol. (1997) (22)
- Lipid signalling (1998) (22)
- Disruption by Lithium of Phosphoinositide Signalling in Cerebellar Granule Cells in Primary Culture (1998) (21)
- Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells. (2004) (21)
- The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. (1993) (21)
- The turkey erythrocyte beta-adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein alpha subunits. (1994) (21)
- Transiently selective activation of phosphoinositide turnover in layer V pyramidal neurons after specific mGluRs stimulation in rat somatosensory cortex during early postnatal development (1995) (21)
- Lithium treatment of affective disorders: effects of lithium on the inositol phospholipid and cyclic AMP signalling pathways. (1992) (20)
- Production of inositol trisphosphates and inositol tetrakisphosphate in stimulated pancreatic islets. (1987) (19)
- Noradrenaline-stimulated inositol phospholipid breakdown in rat dorsal lateral geniculate nucleus neurones (1986) (18)
- Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. (1993) (18)
- Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes. (1993) (17)
- Characterization of the Effects of Lithium and Inositol on Phosphoinositide Turnover in Cerebellar Granule Cells in Primary Culture (1996) (15)
- Cross-talk between phospholipase C and phosphoinositide 3-kinase signalling pathways. (1997) (15)
- Metabolic switching of PI3K-dependent lipid signals. (2007) (15)
- Ca2(+)-stimulatable and protein kinase C-inhibitable accumulation of inositol 1,3,4,6-tetrakisphosphate in human platelets. (1990) (15)
- The neuropeptide Phe‐Met‐Arg‐Phe‐NH2 (FMRFamide) increases levels of inositol 1,4,5‐trisphosphate in the tentacle retractor muscle of Helix aspersa (1993) (15)
- Phosphatidylinositol(3,4,5)trisphosphate (Ptdins(3,4,5)P3) mass measurement using a radioligand displacement assay. (1998) (13)
- Studies of inositol analogues as inhibitors of the phosphoinositide pathway, and incorporation of 2-deoxy-2-fluoro-myo-inositol to give analogues of phosphatidylinositol intermediates. (1991) (13)
- Regulation of phospholipase C. (1990) (13)
- Advances in procedures for the detection and localization of inositol phospholipid signals in cells, tissues, and enzyme assays. (2003) (13)
- Visualization of agonist-stimulated inositol phospholipid turnover in individual neurons of the rat cerebral cortex and hippocampus (1994) (13)
- Indirect mechanisms of carcinogenesis via downregulation of PTEN function. (2010) (12)
- Mu-receptor binding in physiological media: Comparison with isolated tissue data (1984) (12)
- Sympathetic denervation impairs agonist-stimulated phosphatidylinositol metabolism in rat parotid glands. (1983) (12)
- Cellular responses to stress (1999) (10)
- Inositol phosphates: concord or confusion? (1986) (10)
- Time-dependent inhibition of phospholipase C beta-catalysed phosphoinositide hydrolysis: a comparison of different assays. (1996) (10)
- β 1-Integrin and PTEN control the phosphorylation of protein kinase C (9)
- Signaling by Neurotrophic Factors: Activation of Phosphoinositide 3-Kinase by Nerve Growth Factor (1993) (9)
- Apparent variations in the activation characteristics of human erythrocyte membrane Ca2+-pump ATPase may be caused by variable membrane permeability (1981) (8)
- Dephosphorylation of 1D-myo-inositol 1,4-bisphosphate in rat liver. (1988) (8)
- Twenty-fifth Colworth medal lecture. The cellular functions of myo-inositol. (1989) (7)
- Inositol lipids and phosphates. (1990) (7)
- Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C. (1988) (6)
- Measurement of the metabolic turnover of the 4- and 5-phosphates of phosphatidylinositol 4,5-bisphosphate in erythrocytes (1982) (6)
- Review myo-Inositol metabolites as cellular signals (1990) (6)
- Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib (2005) (5)
- Inositol lipid signalling exacts a transfer fee (1993) (4)
- G protein-dependent regulation of phospholipase C. (1989) (4)
- Receptor-dependent generation of intracellular signals from inositol phospholipids in parotid gland and brain. (1985) (3)
- The stereoselective recognition of substrates by phosphoinositide kinases. Studies using synthetic stereoisomers of dipalmitoyl phosphatidylinositol. (1992) (3)
- Avian G-protein-regulated phospholipase C. (1991) (3)
- Kinetic Analysis of Phospholipase C Isoforms Using Phospholipid-Detergent Mixed Micelles (1995) (3)
- Second messengers or second agonists? (1987) (3)
- The activity of a phospholipase Cβ assayed using phospholipid monolayers (1993) (2)
- Regulation of clathrin-coated vesicle formation. (2001) (2)
- Thehaemopoietic growth factors interleukin 3andcolony stimulating factor-1 stimulate proliferation butdonotinduce inositol lipid breakdown inmurine bone-marrow-derived (1986) (2)
- Characterisation of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts. (1993) (2)
- Lipid kinases and trans-Golgi network membrane dynamics. (1999) (2)
- Inhibition of human erythrocyte membrane phosphatidylinositol 4-kinase by phospholipid analogues (1994) (1)
- The turkey erythrocyte fl . adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein a subunits (2005) (1)
- Phosphoinositide-Dependent Protein Kinases (2021) (1)
- Phosphoinositide 3-kinase dependent lipid signals in cellular survival responses (2003) (1)
- The activity of a phospholipase C beta assayed using phospholipid monolayers. (1993) (1)
- Localisation of agonist stimulated CMP-phosphatidate accumulation in single mammalian neurones. (1993) (1)
- Inositol phospholipid-dependent cellular signalling: opportunities for drug discovery. (1990) (1)
- Chemotactic peptides but not macrophage colony stimulating factor effect the synthesis of inositol lipids in macrophages. (1991) (1)
- reveals differences in expression of proteins regulating motility Comparative proteomics of primitive hematopoietic cell populations (2013) (1)
- The survival signals stimulated by interleukin 3 include a phosphatidylinositol 3 kinase/PKB mediated translocation of the GLUT 1 glucose transporter to the cell surface. (1999) (0)
- Measuring the lipid binding properties of proteins: the examples of PDK1, PKB, and EEA1 (1999) (0)
- Biochemical Pharmacology of Substance P Receptors (1984) (0)
- Adaptations of Receptor-Dependent Phosphatidylinositol 4,5-Bisphosphate Breakdown (1987) (0)
- Evidence fortwodistinct roles forNa+/H+antiport activation (1990) (0)
- PIP3 mass measurement using a radioligand displacement assay (1998) (0)
- OF INOSITOL PYROPHOSPHATES AND METABOLIC RELATIONSHIPS IN DEFINING BIOLOGICAL ROLES Inositol Hexakisphosphate Kinases : USE Characterization of a Selective Inhibitor of Enzyme Catalysis and Regulation (2009) (0)
- 13 PTEN and PI3 Kinase Signaling in the Nervous System (2009) (0)
- Not all mung beans and magic Methods in inositide research (1991) (0)
- Cloning and characterisation of novel phosphoinositide effector proteins (2001) (0)
- Investigation of the localization of the second messenger phosphatidylinositol-(3,4,5)-trisphosphate in chronic myeloid leukemia (2002) (0)
- The Role of Endogenously Stimulated Protein Kinase C in Regulating (1990) (0)
- Agonist and Guanine Nucleotide Regulation of P 2Y Purinergic Receptor-Linked Phospholipase C (1990) (0)
- REGULATION OF THE ACTIVITY OF p2lras IN T-LYMPHOCYTES. (2007) (0)
- Ca2+-Mobilizing Agonists Stimulate a Polyphosphoinositide-Specific Phospholipase C in Rat Parotid Gland (1985) (0)
- An analysis of myo-I 3 Hlinositol trisphosphates found in myo-I 3 Hlinositol prelabelled avian erythrocytes (2005) (0)
- Dundee did well (1995) (0)
- PTEN, A Tumour Suppresser Is A 3 Phosphorylated Phosphoinositide 3 Phosphatase (1999) (0)
- UBIQUITINATION OF PTEN INHIBITS PHOSPHATASE ACTIVITY AND IS ENHANCED BY MEMBRANE TARGETING AND HYPEROSMOTIC STRESS (2010) (0)
- Characterisation of a PTEN homologue from Drosophila (2001) (0)
- Kinases/Phosphatases | Phosphoinositide-Dependent Protein Kinases (2021) (0)
- Visualization of receptor coupled phosphoinositide turnover in single neurons and a glial cell line in culture. (1994) (0)
- The Metabolic Fates and Cellular Functions of Myoinositol (1993) (0)
- Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2 (2012) (0)
- A novel tool for the detection of phosphatidylinositol-(3,4,5)-trisphosphate in primitive hematopoietic stem cells : characterisation of the response to IL-3 and Bcr-Abl. (2001) (0)
- A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes. (1986) (0)
- Substance P-Stimulated Phosphatidylinositol Breakdown in Guinea Pig Ileum (1984) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With C. Peter Downes?
C. Peter Downes is affiliated with the following schools:
