Charles P. O’brien
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Charles P. O’brien's Degrees
- Doctorate Medicine University of Pennsylvania
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(Suggest an Edit or Addition)Charles P. O’brien's Published Works
Published Works
- An Improved Diagnostic Evaluation Instrument for Substance Abuse Patients: The Addiction Severity Index (1980) (3118)
- Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. (2000) (2337)
- New Data from the Addiction Severity Index Reliability and Validity in Three Centers (1985) (1529)
- Limbic activation during cue-induced cocaine craving. (1999) (1520)
- Naltrexone in the treatment of alcohol dependence. (1992) (1020)
- DSM-5 criteria for substance use disorders: recommendations and rationale. (2013) (1008)
- Predicting response to alcohol and drug abuse treatments. Role of psychiatric severity. (1983) (825)
- Therapist success and its determinants. (1985) (754)
- An international consensus for assessing internet gaming disorder using the new DSM-5 approach. (2014) (748)
- Conditioning factors in drug abuse: can they explain compulsion? (1998) (654)
- Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients (2002) (582)
- A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients (2003) (523)
- Myths about the treatment of addiction (1996) (521)
- Internet gaming disorder and the DSM-5. (2013) (494)
- Classical Conditioning in Drug‐Dependent Humans a (1992) (482)
- Human immunodeficiency virus seroconversion among intravenous drug users in- and out-of-treatment: an 18-month prospective follow-up. (1993) (473)
- Naltrexone and alcohol dependence. Role of subject compliance. (1997) (425)
- A New Measure of Substance Abuse Treatment Initial Studies of the Treatment Services Review (1992) (419)
- Benzodiazepine use, abuse, and dependence. (2005) (411)
- A range of research-based pharmacotherapies for addiction. (1997) (394)
- Similarity of outcome predictors across opiate, cocaine, and alcohol treatments: role of treatment services. (1994) (390)
- Sociopathy and psychotherapy outcome. (1985) (384)
- A Double-Blind, Placebo-Controlled Trial of Modafinil for Cocaine Dependence (2005) (375)
- Psychotherapy for opiate addicts. Does it help? (1983) (371)
- Anticraving medications for relapse prevention: a possible new class of psychoactive medications. (2005) (361)
- Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study (2007) (361)
- Cue reactivity and cue reactivity interventions in drug dependence. (1993) (349)
- Prelude to Passion: Limbic Activation by “Unseen” Drug and Sexual Cues (2008) (348)
- A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. (2003) (330)
- Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial. (2006) (329)
- The Status of Disulfiram: A Half of a Century Later (2006) (329)
- Effect of naltrexone on alcohol "high" in alcoholics. (1995) (318)
- Conditioned responses to cocaine-related stimuli in cocaine abuse patients (2005) (304)
- Integrating systemic cue exposure with standard treatment in recovering drug dependent patients. (1990) (299)
- A pilot trial of topiramate for the treatment of cocaine dependence. (2004) (283)
- Cocaine dependence: a disease of the brain's reward centers. (2001) (276)
- Comparing attentional bias to smoking cues in current smokers, former smokers, and non-smokers using a dot-probe task. (2002) (271)
- Three decision-making tasks in cocaine-dependent patients: do they measure the same construct? (2001) (271)
- Classically conditioned responses in opioid and cocaine dependence: a role in relapse? (1988) (263)
- Evaluating the effectiveness of addiction treatments: reasonable expectations, appropriate comparisons. (1996) (257)
- Issues for DSM-V: should obesity be included as a brain disorder? (2007) (257)
- Addiction and dependence in DSM-V. (2011) (254)
- Neurobiology of addiction: treatment and public policy ramifications (2005) (253)
- Comparing levels of cocaine cue reactivity in male and female outpatients. (1999) (253)
- Extended-Release Naltrexone to Prevent Opioid Relapse in Criminal Justice Offenders. (2016) (248)
- Abstinent opiate abusers exhibit conditioned craving, conditioned withdrawal and reductions in both through extinction. (1986) (247)
- Increased Effectiveness of Substance Abuse Treatment: A Prospective Study of Patient‐Treatment “Matching” (1983) (240)
- Pharmacogenetic approaches to the treatment of alcohol addiction (2011) (239)
- Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence (1997) (225)
- Problem-service 'matching' in addiction treatment. A prospective study in 4 programs. (1997) (225)
- Critical assessment of how to study addiction and its treatment: human and non-human animal models. (2005) (216)
- Treatment of patients with substance use disorders, second edition. American Psychiatric Association. (2006) (216)
- What's in a word? Addiction versus dependence in DSM-V. (2006) (215)
- Experimental analysis of conditioning factors in human narcotic addiction. (1975) (213)
- Naltrexone pharmacotherapy for opioid dependent federal probationers. (1997) (210)
- Is treatment for substance abuse effective? (1982) (210)
- Predicting treatment response to naltrexone: the influence of craving and family history. (2001) (210)
- Comparative effectiveness and costs of inpatient and outpatient detoxification of patients with mild-to-moderate alcohol withdrawal syndrome. (1989) (208)
- A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence. (2010) (205)
- Current status of co-occurring mood and substance use disorders: a new therapeutic target. (2015) (205)
- Development of psychiatric illness in drug abusers. Possible role of drug preference. (1979) (204)
- Conditioned narcotic withdrawal in humans. (1977) (201)
- Concurrent naltrexone and prolonged exposure therapy for patients with comorbid alcohol dependence and PTSD: a randomized clinical trial. (2013) (201)
- Predicting the outcome of psychotherapy. findings of the Penn Psychotherapy Project. (1980) (199)
- Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues. (2008) (197)
- Naltrexone in the treatment of alcoholism: a clinical review. (1996) (195)
- Psychotherapy in community methadone programs: a validation study. (1995) (190)
- Severity of psychiatric symptoms as a predictor of benefits from psychotherapy: the Veterans Administration-Penn study. (1984) (186)
- Internet Gaming Disorder in the DSM-5 (2015) (185)
- Effect of smoking cues and cigarette availability on craving and smoking behavior. (1995) (178)
- Can induced moods trigger drug-related responses in opiate abuse patients? (1994) (174)
- A learning model of addiction. (1992) (171)
- Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study. (2003) (171)
- The Status of Naltrexone in the Treatment of Alcohol Dependence: Specific Effects on Heavy Drinking (2006) (169)
- Effects of varenicline on smoking cue–triggered neural and craving responses. (2011) (153)
- Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone. (1975) (150)
- A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat. (1998) (148)
- Conditioned craving and arousal in cocaine addiction: a preliminary report. (1988) (147)
- Addiction Severity Index (2012) (146)
- The CAGE questionnaire for detection of alcoholism: a remarkably useful but simple tool. (2008) (144)
- Plasma testosterone level and sexual behavior of couples (1978) (144)
- A genetic association study of the mu opioid receptor and severe opioid dependence (2003) (138)
- An Overview of and Rationale for Changes Proposed for Pathological Gambling in DSM-5 (2014) (137)
- Effectiveness of propranolol for cocaine dependence treatment may depend on cocaine withdrawal symptom severity. (2001) (136)
- Naltrexone in the treatment of alcoholism: predicting response to naltrexone. (1995) (136)
- Desipramine treatment of cocaine dependence in methadone-maintained patients. (1992) (134)
- Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: A call to action (2004) (131)
- HEROIN ADDICTION AND RELATED CLINICAL PROBLEMS (2002) (125)
- Are the “Addiction‐related” Problems of Substance Abusers Really Related? (1981) (123)
- Effectiveness and Costs of Inpatient versus Day Hospital Cocaine Rehabilitation (1994) (120)
- Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam (SCH 39166) (1999) (119)
- Relationship of perceived competencies, perceived social support, and gender to substance use in young adolescents. (1997) (118)
- Cocaine withdrawal symptoms and initial urine toxicology results predict treatment attrition in outpatient cocaine dependence treatment. (2001) (117)
- Evidence-based treatments of addiction (2008) (115)
- Alcohol and drug abuse treatment in three different populations: is there improvement and is it predictable? (1986) (114)
- Alcohol potentiates hepatitis C virus replicon expression (2003) (113)
- Group counseling versus individualized relapse prevention aftercare following intensive outpatient treatment for cocaine dependence: initial results. (1997) (111)
- Private substance abuse treatments: are some programs more effective than others? (1993) (111)
- Conditioned responses in a methadone population. A comparison of laboratory, clinic, and natural settings. (1986) (109)
- Treating and preventing adolescent mental health disorders: What We Know and What We Don't Know. A Research Agenda for Improving the Mental Health of Our Youth (2005) (109)
- Risk factors for needle sharing among methadone-treated patients. (1991) (107)
- Can independent judges recognize different psychotherapies? An experience with manual-guided therapies. (1982) (106)
- Pharmacological and behavioral treatments of cocaine dependence: controlled studies. (1988) (105)
- Drug Treatment as HIV Prevention: A Research Update (2010) (104)
- Crack cocaine abuse: an epidemic with many public health consequences. (1996) (104)
- Naltrexone vs Placebo for the Treatment of Alcohol Dependence: A Randomized Clinical Trial. (2015) (103)
- The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study. (2009) (103)
- Twelve-month follow-up of psychotherapy for opiate dependence. (1987) (102)
- The Relation of Plasma Androgen Levels to Sexual Behaviors and Attitudes of Women1 (1982) (101)
- Psychotherapy for opiate addicts. (1983) (101)
- Effect of random versus nonrandom assignment in a comparison of inpatient and day hospital rehabilitation for male alcoholics. (1995) (100)
- A Double-Blind, Placebo-Controlled Pilot Trial of Quetiapine for the Treatment of Type A and Type B Alcoholism (2007) (99)
- Nipping Cue Reactivity in the Bud: Baclofen Prevents Limbic Activation Elicited by Subliminal Drug Cues (2014) (98)
- Naltrexone for heroin dependence treatment in St. Petersburg, Russia. (2004) (97)
- DAT Genotype Modulates Brain and Behavioral Responses Elicited by Cigarette Cues (2009) (96)
- Predictors of participation in aftercare sessions and self-help groups following completion of intensive outpatient treatment for substance abuse. (1998) (91)
- A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. (2013) (90)
- Naltrexone and the Treatment of Alcohol-Dependence: Initial Observations (1990) (90)
- Misuse and abuse of diazepam: an increasingly common medical problem. (1975) (90)
- Relationships among physiological and self-report responses produced by cocaine-related cues. (1997) (90)
- Treatment of patients with substance use disorders (2006) (90)
- Extinguishing conditioned responses during opiate dependence treatment turning laboratory findings into clinical procedures. (1986) (88)
- Mental effects of high-dosage levodopa. (1971) (87)
- Retrospective study: influence of menstrual cycle on cue-induced cigarette craving. (2004) (87)
- Improving Naltrexone Response (2000) (86)
- Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia. (2006) (86)
- Combining Medication and Psychosocial Treatments for Addictions: The BRENDA Approach (2001) (84)
- A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence. (2008) (84)
- A pilot trial of olanzapine for the treatment of cocaine dependence. (2003) (84)
- Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence. (2008) (83)
- Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: a retrospective analysis. (2008) (82)
- Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption. (2001) (82)
- Glutamatergic Agents for Cocaine Dependence (2003) (81)
- Role of conditioning factors in the development of drug dependence. (1986) (81)
- Group vs individual psychotherapy with schizophrenics. A controlled outcome study. (1972) (81)
- Substance Use Disorders in the U.S. Armed Forces (2013) (80)
- A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms. (2006) (79)
- Naltrexone biotransformation and incidence of subjective side effects: a preliminary study. (1997) (78)
- Treatment of patients with substance use disorders, second edition. American Psychiatic Association. (2006) (78)
- Clinical experience with naltrexone. (1975) (74)
- Caffeine: behavioral effects of withdrawal and related issues. (2002) (73)
- Effect of naltrexone on food intake, hunger, and satiety in obese men (1987) (73)
- Research advances in the understanding and treatment of addiction. (2003) (72)
- Naltrexone in the treatment of alcoholism. (1997) (72)
- Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals (2014) (71)
- Naltrexone: a clinical perspective. (1984) (71)
- Effects of naltrexone administered repeatedly across 30 or 60 days on ethanol consumption using a limited access procedure in the rat. (1998) (70)
- Continuing care for cocaine dependence: comprehensive 2-year outcomes. (1999) (69)
- Relapse to opioid use disorder after inpatient treatment: Protective effect of injection naltrexone. (2018) (69)
- Sexual problems of heroin addicts. (1974) (68)
- Rational development of addiction pharmacotherapies: successes, failures, and prospects. (2012) (68)
- Alcoholism treatment after liver transplantation: lessons learned from a clinical trial that failed. (2001) (67)
- The Dopamine Receptor D2 (DRD2) SNP rs1076560 is Associated with Opioid Addiction (2014) (67)
- Using cue reactivity to screen medications for cocaine abuse: a test of amantadine hydrochloride. (1992) (66)
- A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence. (2015) (66)
- REVIEW: Targeting treatments for alcohol dependence: the pharmacogenetics of naltrexone (2006) (66)
- The effects of naltrexone on alcohol and cocaine use in dually addicted patients. (1999) (66)
- Medical management of alcohol dependence: clinical use and limitations of naltrexone treatment. (1995) (65)
- Results of an initial clinical trial of varenicline for the treatment of cocaine dependence. (2012) (65)
- Predictors of favorable outcome following naltrexone treatment. (1983) (64)
- Cocaine withdrawal severity and urine toxicology results from treatment entry predict outcome in medication trials for cocaine dependence. (2002) (63)
- Results from a pilot clinical trial of varenicline for the treatment of alcohol dependence. (2013) (63)
- Detecting smoking following smoking cessation treatment. (2002) (63)
- Development of the Revised Opioid Risk Tool to Predict Opioid Use Disorder in Patients with Chronic Nonmalignant Pain. (2019) (63)
- Mood states can elicit conditioned withdrawal and craving in opiate abuse patients. (1987) (62)
- Association Between the Catechol-O-Methyltransferase Val158Met Polymorphism and Cocaine Dependence (2008) (61)
- A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention. (2008) (60)
- Coerced treatment for substance abuse problems detected through workplace urine surveillance: is it effective? (1996) (60)
- Dopamine receptor partial agonists could address the duality of cocaine craving. (2000) (60)
- Amantadine in the early treatment of cocaine dependence: a double-blind, placebo-controlled trial. (1996) (58)
- Psychotherapy and counseling for methadone-maintained opiate addicts: results of research studies. (1990) (57)
- Amantadine may facilitate detoxification of cocaine addicts. (1992) (57)
- Prognostic significance of antisocial personality disorder in cocaine-dependent patients entering continuing care. (2000) (57)
- Mood state and recent cocaine use are not associated with levels of cocaine cue reactivity. (2000) (56)
- A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal. (2008) (56)
- Matching substance abuse patients to appropriate treatments: a conceptual and methodological approach. (1980) (56)
- A multisite pilot study of extended-release injectable naltrexone treatment for previously opioid-dependent parolees and probationers. (2012) (56)
- Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations. (2013) (56)
- Treatment response in psychiatrically impaired drug abusers. (1981) (54)
- Corrections and revised analyses for psychotherapy in methadone maintenance patients. (1990) (54)
- Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms. (2000) (54)
- How effective is substance abuse treatment--compared to what? (1992) (53)
- The addiction severity index in three different populations. (1984) (53)
- Psychosocially enhanced treatment for cocaine-dependent mothers: evidence of efficacy. (2000) (53)
- Extinction of conditioned responses in abstinent cocaine or opioid users. (1987) (53)
- Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytes. (2002) (53)
- A VBM study demonstrating ‘apparent’ effects of a single dose of medication on T1-weighted MRIs (2012) (52)
- Under the influence? Drugs and the American work force. (1995) (51)
- Developing treatments that address classical conditioning. (1993) (51)
- Recent developments in the pharmacotherapy of substance abuse. (1996) (51)
- Naltrexone for probationers and parolees. (2006) (51)
- Desipramine Treatment for Cocaine Dependence: Role of Antisocial Personality Disorder (1994) (50)
- The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat (2001) (50)
- Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations (2012) (48)
- Carbamazepine treatment for cocaine dependence. (1995) (48)
- Random versus nonrandom assignment in the evaluation of treatment for cocaine abusers. (1998) (48)
- Gender differences in comorbidly depressed alcohol-dependent outpatients. (1997) (48)
- Covariates of craving in actively drinking alcoholics. (2010) (46)
- The relationship of plasma estradiol to sexual behavior in young women. (1978) (46)
- A double-blind, placebo-controlled trial of modafinil for cocaine dependence. (2012) (46)
- Do caffeine‐containing analgesics promote dependence? A review and evaluation (2000) (45)
- The effect of alcohol and smoking on testosterone function and aggression in chronic alcoholics. (1977) (45)
- Hepatic safety of once-monthly injectable extended-release naltrexone administered to actively drinking alcoholics. (2008) (44)
- Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: a longitudinal perfusion fMRI study. (2011) (44)
- Depression in veterans two years after Viet Nam. (1977) (44)
- Psychiatric disorders in opioid-dependent patients. (1984) (44)
- A randomized trial of oral naltrexone for treating opioid-dependent offenders. (2010) (43)
- Effects of an appointment reminder call on patient show rates. (1995) (43)
- Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence (2012) (43)
- Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence (2005) (43)
- [Buprenorphine in the treatment of opiate dependence]. (1994) (43)
- THE USE OF ANTIDEPRESSANTS WITH METHADONE IN DEPRESSED MAINTENANCE PATIENTS * (1982) (42)
- Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction (2012) (42)
- Cocaine dependence severity predicts outcome in outpatient detoxification from cocaine and alcohol. (2004) (42)
- Hormone secretion in methadone-dependent and abstinent patients. (1988) (42)
- Naltrexone: a short-term treatment for opiate dependence. (1981) (41)
- Types of conditioning found in drug-dependent humans. (1988) (41)
- Extended‐release naltrexone modulates brain response to drug cues in abstinent heroin‐dependent patients (2014) (41)
- Prevention of Eating Disorders (2005) (40)
- Reward-related Brain Response and Craving Correlates of Marijuana Cue Exposure: A Preliminary Study in Treatment-seeking Marijuana-dependent Subjects (2013) (40)
- Effects of contingent payment on compliance with a naltrexone regimen. (1979) (40)
- Unreinforced self-injections: effects on rituals and outcome in heroin addicts. (1979) (39)
- Naloxone can alter experimental pain and mood in humans (1981) (39)
- CLINICAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS * (1978) (39)
- The impact of sex on brain responses to smoking cues: a perfusion fMRI study (2013) (38)
- Conditioning of narcotic abstinence symptoms in human subjects. (1975) (38)
- Cynthia ' s Dilemma : Consenting to Heroin Prescription (2017) (36)
- A comparison of the effects of 6-β naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats (2002) (36)
- A functional prodynorphin promoter polymorphism and opioid dependence (2005) (36)
- Failure of ritanserin to block cocaine cue reactivity in humans. (1996) (36)
- CONDITIONING MECHANISMS IN DRUG DEPENDENCE (1992) (35)
- Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine (2013) (34)
- Use of disulfiram for alcoholics in methadone maintenance programs. A Veterans Administration Cooperative Study. (1983) (34)
- Behavioral therapies for substance abuse. (1985) (33)
- Neural correlates of adherence to extended-release naltrexone pharmacotherapy in heroin dependence (2015) (33)
- Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat. (2002) (33)
- Long-term opioid blockade and hedonic response: preliminary data from two open-label extension studies with extended-release naltrexone. (2010) (33)
- Increase in desipramine serum levels associated with methadone treatment. (1989) (33)
- Psychiatric symptoms, risky behavior, and HIV infection. (1997) (33)
- Conditioning in human opiate addicts (1976) (32)
- Pretreatment source of income and response to methadone maintenance: a follow-up study. (1981) (32)
- Treatment response and safety of ambulatory medical detoxication. (1988) (32)
- Research on psychopathology and addiction: treatment implications. (1990) (31)
- Laboratory exposure to cocaine cues does not increase cocaine use by outpatient subjects. (1998) (31)
- Follow-up of Vietman veterans. I. Relapse to drug use after Vietnam service. (1980) (31)
- Clinical Medications Development for Opiate Addiction: Focus on Nonopioids and Opioid Antagonists for the Amelioration of Opiate Withdrawal Symptoms and Relapse Prevention (1997) (30)
- Opioid therapy in patients with chronic noncancer pain: diagnostic and clinical challenges. (2011) (30)
- Cost‐effectiveness of extended release naltrexone to prevent relapse among criminal justice‐involved individuals with a history of opioid use disorder (2017) (29)
- Griffiths et al.'s comments on the international consensus statement of internet gaming disorder: furthering consensus or hindering progress? (2016) (29)
- Gender and psychiatric comorbidity: impact on clinical presentation of alcohol dependence. (2000) (29)
- A randomized, double-blind, placebo-controlled study of ritanserin pharmacotherapy for cocaine dependence. (2001) (29)
- Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence. (2008) (29)
- Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population (2005) (29)
- Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence. (2009) (28)
- Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment. (2010) (28)
- The Alcohol Clinical Trials Initiative (ACTIVE): Purpose and Goals for Assessing Important and Salient Issues for Medications Development in Alcohol Use Disorders (2012) (28)
- Results of two levels of adjunctive treatment used with the nicotine patch. (1997) (27)
- Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence (2010) (27)
- A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients. (2002) (27)
- Treatment of alcoholism as a chronic disorder. (1994) (27)
- Acute baclofen diminishes resting baseline blood flow to limbic structures: a perfusion fMRI study. (2012) (26)
- Extended-release naltrexone to prevent relapse among opioid dependent, criminal justice system involved adults: rationale and design of a randomized controlled effectiveness trial. (2015) (26)
- The combination of phentermine and fenfluramine reduced cocaine withdrawal symptoms in an open trial. (2000) (26)
- A clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction. (1981) (26)
- Assessment and extinction of conditioned withdrawal-like responses in an integrated treatment for opiate dependence. (1984) (26)
- Open trials as a method of prioritizing medications for inclusion in controlled trials for cocaine dependence. (1999) (25)
- Myxoid tumor of the uterus and right atrial myxomas. (1983) (25)
- Overview: the treatment of drug dependence. (1994) (25)
- A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence. (2011) (24)
- Psychological severity and response to alcoholism rehabilitation. (1981) (24)
- Emotional, physical and sexual abuse are associated with a heightened limbic response to cocaine cues (2017) (24)
- Naltrexone inhibits alcohol‐mediated enhancement of HIV infection of T lymphocytes (2006) (23)
- Anticholinergic toxic psychosis in drug abusers treated with benztropine. (1974) (23)
- Cocaine dependence: the challenge for pharmacotherapy (2002) (23)
- Naltrexone for alcoholic adolescents. (1997) (23)
- Clinical correlations with carbohydrate-deficient transferrin levels in women with alcoholism. (1998) (23)
- Effects Of Use (1994) (23)
- Conditioned tolerance in human opiate addicts (2005) (22)
- ENDORPHIN LEVELS IN OPIOID‐DEPENDENT HUMAN SUBJECTS: A LONGITUDINAL STUDY * (1982) (22)
- Absence of naloxone sensitivity in obese humans. (1982) (22)
- Commentary on Tao et al. (2010): Internet addiction and DSM‐V (2010) (22)
- Endogenous opioids in cerebrospinal fluid of opioid-dependent humans (1988) (22)
- Nondependent monkeys self-administer hydromorphone. (1985) (22)
- Reproductive Hormone Levels and Sexual Behaviors of Young Couples During the Menstrual Cycle (1977) (22)
- Molecular Genetics and New Medication Strategies for Opioid Addiction. (2018) (21)
- A pilot trial of piracetam and ginkgo biloba for the treatment of cocaine dependence. (2003) (21)
- Psychiatric symptoms, high risk behaviors and HIV positivity among methadone patients. (1990) (21)
- Group therapy for schizophrenia: a practical approach. (1975) (21)
- 6-β-Naltrexol Reduces Alcohol Consumption in Rats (2000) (20)
- Neuronal calcium sensor-1 and cocaine addiction: A genetic association study in African-Americans and European Americans (2012) (20)
- Classical conditioning in opiate dependence. (1984) (20)
- Do patient characteristics moderate the effect of extended-release naltrexone (XR-NTX) for opioid use disorder? (2018) (20)
- Does modafinil produce euphoria? (2006) (20)
- GENETIC STUDY: Analysis of variations in the tryptophan hydroxylase‐2 (TPH2) gene in cocaine dependence (2006) (20)
- Conditioned drug responses to naturalistic stimuli. (1979) (19)
- Conditioning factors may help to understand and prevent relapse in patients who are recovering from drug dependence. (1991) (19)
- Neuroplasticity in addictive disorders (2009) (19)
- Measurement and extinction of conditioned withdrawal-like responses in opiate-dependent patients. (1984) (19)
- Extended-release naltrexone for pre-release prisoners: A randomized trial of medical mobile treatment. (2017) (18)
- Treatment of Drug and Alcohol Abuse. (1984) (18)
- Novel exonic μ‐opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence (2005) (18)
- Position statement on methadone maintenance treatment. (1994) (18)
- Identifying Risk Factors for Marijuana Use Among Veterans Affairs Patients (2010) (18)
- The mosaic of addiction. (2004) (18)
- Addressing psychiatric comorbidity. (1991) (18)
- Effects of extended-release naltrexone on the brain response to drug-related stimuli in patients with opioid use disorder. (2018) (18)
- PSYCHOTHERAPY FOR OPIATE ADDICTION: SOME PRELIMINARY RESULTS (1981) (17)
- Aberrant behaviors in a primary care-based cohort of patients with chronic pain identified as misusing prescription opioids. (2013) (17)
- Naltrexone Maintenance: Effect on Morphine Sensitivity in Normal Volunteers. (1993) (17)
- Low Risk of Producing an Opioid Use Disorder in Primary Care by Prescribing Opioids to Prescreened Patients with Chronic Noncancer Pain (2018) (17)
- Risk for alcoholism and methadone treatment. A longitudinal study. (1980) (16)
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