Cyrus R. Creveling

Cyrus R. Creveling's AcademicInfluence.com Rankings

Cyrus R. Creveling

Biology

#12242

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#15706

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Neuroscience

#2037

World Rank

#2094

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Biology

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Cyrus R. Creveling's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A RADIOISOTOPIC METHOD FOR MEASURING THE FORMATION OF ADENOSINE 3′,5′‐CYCLIC MONOPHOSPHATE IN INCUBATED SLICES OF BRAIN (1969) (448)
Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3':5'-monophosphate- generating systems, receptors, and enzymes (1985) (400)
Chapter 6: Estrogen Metabolism by Conjugation (2000) (233)
Serotonin, norepinephrine, and related compounds in bananas. (1958) (215)
Norepinephrine metabolism in rat brain and heart. (1961) (194)
Substrates and inhibitors of dopamine-β-oxidase (1962) (164)
Estrogen metabolism by conjugation. (2000) (160)
Stimulated formation of adenosine 3',5'-cyclic phosphate in cerebral cortex: synergism between electrical activity and biogenic amines. (1970) (154)
Chemical, Enzymatic and Metabolic Studies on the Mechanism of Oxidation of Dopamine1 (1959) (146)
Catechol-O-methyltransferase. II. A new class of inhibitors of catechol-o-methyltransferase; 3,5-dihydroxy-4-methoxybenzoic acid and related compounds. (1970) (145)
Immunohistochemical demonstration of catechol-O-methyltransferase in mammalian brain (1979) (145)
Fluoronorepinephrines: specific agonists for the activation of alpha and beta adrenergic-sensitive cyclic AMP-generating systems in brain slices. (1980) (126)
Biological Methylation and Drug Design (1986) (120)
Batrachotoxin-induced depolarization and [3H]batrachotoxinin-a 20 alpha-benzoate binding in a vesicular preparation from guinea pig cerebral cortex. (1983) (106)
Cyclic AMP-generating systems: regional differences in activation by adrenergic receptors in rat brain (1981) (103)
The combined use of α-methyltyrosine and threo-dihydroxyphenylserine—selective reduction of dopamine levels in the central nervous system (1968) (99)
Biochemistry of S-Adenosylmethionine and Related Compounds (1982) (98)
Catechol O-methyltransferase. IV. Factors affecting m- and p-methylation of substituted catechols. (1972) (97)
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. (1985) (91)
Enzymic conversion of p-tyramine to p-hydroxyphenylethanolamine (norsynephrin) (1960) (91)
Oxygen-dependent reaction of 6-hydroxydopamine, 5,6-dihydroxytryptamine, and related compounds with proteins in vitro: a model for cytotoxicity. (1976) (90)
Accumulations of Cyclic AMP in Adenine‐Labeled Cell‐free Preparations from Guinea Pig Cerebral Cortex: Role of α‐Adrenergic and H1‐Histaminergic Receptors (1980) (90)
LOCALIZATION OF DOPAMINE‐β‐OXIDASE IN BRAIN (1959) (79)
Cyclic adenosine 3',5'-monophosphate formation in brain slices: stimulation by batrachotoxin, ouabain, veratridine, and potassium ions. (1970) (78)
The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines. (1966) (67)
The chemistry and biology of ring‐fluorinated biogenic amines (1984) (61)
Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines. (1979) (59)
The Role of Catechol-O-Methyltransferase in the Inactivation of Catecholestrogen (2003) (56)
Use of dansyl derivatives and mass spectrometry for identification of biogenic amines. (1968) (55)
Localization of catechol-O-methyltransferase in the leptomeninges, choroid plexus and ciliary epithelium: implications for the separation of central and peripheral catechols (1981) (53)
The effect of ring-fluorination on the rate of O-methylation of dihydroxyphenylalanine (DOPA) by catechol-O-methyltransferase: significance in the development of 18F-PETT scanning agents. (1985) (48)
Membrane Potentials in Cell‐free Preparations from Guinea Pig Cerebral Cortex: Effect of Depolarizing Agents and Cyclic Nucleotides (1980) (46)
Effect of fluorine substitution on the agonist specificity of norepinephrine. (1979) (45)
Alpha-adrenergic potentiation of beta-adrenergic stimulation of rat pineal N-acetyltransferase. Studies using cirazoline and fluorine analogs of norepinephrine. (1984) (44)
The effect of histamines and other compounds on the formation of adenosine 3′,5′‐monophosphate in slices from cerebral cortex (1970) (43)
Uptake and binding of dopamine and 6-hydroxydopamine in murine neuroblastoma and fibroblast cells. (1976) (42)
The synthesis of 2,4,5-trihydroxyphenylalanine (6-hydroxydopa). A centrally active norepinephrine-depleting agent. (1969) (41)
2,4,5-TRIHYDROXYPHENETHYLAMINE, A NEW METABOLITE OF 3,4-DIHYDROXYPHENETHYLAMINE (1959) (41)
Effect of membrane depolarization and biogenic amines on the formation of cyclic AMP in incubated brain slices. (1970) (41)
Catechol O-Methyltransferase: III. m- and p-O-Methylation of Catecholamines and Their Metabolites (1970) (40)
Inhibition of norepinephrine synthesis in mouse brain by blockade of dopaminebeta-oxidase. (1962) (40)
Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer. (1998) (39)
An alternative route for biosynthesis of norepinephrine. (1962) (37)
Dihydroxytryptamines: effects on noradrenergic function in mouse heart in vivo. (1975) (36)
Catechol O-methyltransferase. 3. M- and p-O-methylation of catecholamines and their metabolites. (1970) (36)
Development and evaluation of a computer-automated color tv tracking system for automatic recording of the social and exploratory behavior of small animals (1982) (35)
Inhibitors of norepinephrine metabolism in vivo. (1959) (34)
Nuclear localization of catechol-O-methyltransferase in neoplastic and nonneoplastic mammary epithelial cells. (2000) (32)
Altered responsiveness of adenosine 3′,5′-monophosphate-generating systems in rat cortical slices after lesions of the medial forebrain bundle (1975) (32)
Immunohistochemical localization of catechol methyltransferase in normal and cancerous breast tissues of mice and rats. (1983) (32)
False Neurochemical Transmitters: Combined Clinical Staff Conference at the National Institutes of Health (1966) (31)
Immunohistochemical localization of cathechol-O-methyltransferase in circumventricular organs of the rat: Potential variations in the blood-brain barrier to native catechols (1981) (30)
Catechol-O-methyltransferase. I. An enzymatic assay for cardiac norepinephrine. (1969) (30)
Developmental Patterns of Catechol‐O‐Methyltransferase in Genetically Different Rat Strains: Enzymatic and Immunochemical Studies (1980) (29)
Pumiliotoxin alkaloids: a new class of sodium channel agents. (1990) (29)
Regioselectivity of catechol O-methyltransferase. The effect of pH on the site of O-methylation of fluorinated norepinephrines. (1986) (29)
Synthesis and adrenergic activity of ring-fluorinated phenylephrines. (1986) (28)
Nerve growth factor and K‐252a increase catecholamine release from PC12 cells (1990) (28)
Inhibition of dopamine beta-oxidase in vivo by benzyloxyamine and benzylhydrazine analogs. (1963) (28)
Direct observation of 6-fluorodopamine in guinea pig nerve microsacs by 19F NMR. (1983) (27)
On the inability of tryptamine to serve as a precursor of serotonin. (1959) (25)
Electron microscopic identification of adrenergic nerve endings on thyroid epithelial cells. (1975) (25)
Immunocytochemical localization of catechol-O-methyltransferase in the pregnant rat uterus. (1980) (24)
Biogenesis and inactivation of catecholestrogens. (1998) (23)
Biological Methylation and Drug Design: Experimental and Clinical Role of S-Adenosylmethionine (1986) (23)
The "pink spot," 3,4-dimethoxyphenylethylamine, common tea, and schizophrenia. (1970) (23)
(3H)BATRACHOTOXININ A 20α-BENZOATE BINDING TO VOLTAGE-SENSITIVE SODIUM CHANNELS: A RAPID AND QUANITATIVE ASSAY FOR LOCAL ANESTHETIC ACTIVITY IN A VARIETY OF DRUGS (1985) (23)
Phenethylamine isosteres as inhibitors of dopamine β-oxidase (1962) (22)
The binding of fluorocatecholamines to adrenergic and dopaminergic receptors in rat brain membranes. (1980) (22)
Interaction of pumiliotoxin B with an "alkaloid-binding domain" on the voltage-dependent sodium channel. (1992) (22)
Syntheses and adrenergic activities of ring-fluorinated epinephrines. (1988) (22)
Isomers of 2,4,5-trihydroxyphenethylamine (6-hydroxydopamine): long-term effects on the accumulation of (3H)-norepinephrine in mouse heart in vivo. (1973) (21)
The presence of catechol-o-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells (1986) (21)
Effects of ring fluorination on the cardiovascular actions of dopamine and norepinephrine in the dog. (1980) (20)
Immunocytochemical localization of aromatic L-amino acid decarboxylase and catechol-O-methyltransferase in blood vessel wall of the human dental pulp. (1996) (20)
Influence of fluorine substitution on the site of enzymatic O-methylation of fluorinated norepinephrines. (1981) (20)
MECHANISM OF ACTION OF DIHYDROXYTRYPTAMINES (1978) (20)
Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols. (1982) (18)
Assay of enzymes of catecholamine biosynthesis and metabolism. (1971) (17)
Molecular transitions in an induced enzyme with enhanced fluorescence. (1965) (17)
Induction of catechol-O-methyltransferase in the luminal epithelium of rat uterus by progesterone. (1991) (16)
Effect of fluorine substitution on the anodic oxidation of catecholamines and amino acids. (1987) (16)
Relationships between the cellular localization and the physiological function of catechol-O-methyltransferase (1982) (15)
Purification of calcium-dependent phosphodiesterases from rat cerebrum by affinity chromatography on activator protein-sepharose. (1977) (15)
Sulfur analogs of dopamine and norepinephrine. Inhibition of catechol-O-methyltransferase. (1972) (14)
Catechol-O-methyltransferase: Factors Relating to the Carcinogenic Potential of Catecholestrogens (1994) (14)
Release of norepinephrine from brain vesicular preparations: Effects of an adenylate cyclase activator, forskolin, and a phosphodiesterase inhibitor (1982) (14)
The chemorelease of norepinephrine in mouse hearts. Structure-activity relationships. II. Drugs affecting the sympathetic and central nervous systems. (1966) (14)
Mammalian alkaloids : synthesis and O-methylation of (S)- and (R)-3'-hydroxycoclaurine and their N-methylated analogues with S-adenosyl-L-[methyl-14C]methionine in presence of mammalian catechol O-methyltransferase (1991) (14)
The depletion of cardiac norepinephrine by 3,5-dihydroxy-4-methoxyphenethylamine and related compounds. (1967) (14)
On the mechanism of inhibition of dopamine-beta-oxidase by benzyloxyamines. (1963) (13)
IMMUNOCYTOCHEMICAL LOCALIZATION OF CATECHOL-O-METHYLTRANSFERASE IN CARDIOVASCULAR TISSUES (1979) (13)
Norepinephrine depletion and responsiveness of norepinephrine-sensitive cyclic AMP generating systems in guinea pig brain (1976) (12)
2-Fluorohistidine--effects on protein synthesis in cell-free systems and in mouse L cells. (1979) (11)
Norepinephrine uptake sites in cardiac tissue. Lack of affinity of 6-hydroxynorepinephrine and related compounds. (1975) (11)
Local anesthetic properties of opioids and phencyclidines: Interaction with the voltage-dependent, batrachotoxin binding site in sodium channels (1985) (11)
The depletion of norepinephrine-3H from heart by alpha-methyl-m-tyrosine. A novel and convenient method for assaying the inhibition of aromatic amino acid decarboxylase in vivo. (1966) (10)
Mammalian Alkaloids: O‐methylation of (S)‐ and (R)‐dideoxynorlaudanosoline‐1‐carboxylic acid by catechol O‐methyltransferase and identification of a yellow pigment obtained at physiological pH (1988) (10)
A rationale for the design of cell‐specific toxic agents: The mechanism of action of 6‐hydroxydopamine (1976) (10)
GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. (1986) (10)
The combined use of alpha-methyltyrosine and threo-dihydroxyphenylserine--selective reduction of dopamine levels in the central nervous system. (1968) (10)
[260] The use of dansyl derivatives for the identification and quantitation of amines (1971) (9)
Calcium-dependent cyclic nucleotide phosphodiesterase. Inhibition of basal activity by heat-stable factors from rat cerebrum. (1979) (9)
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol. (1991) (9)
2,4,5-Trimethylpyrrole-3-carboxylic acid esters of various alkaloids. (1974) (9)
The chemorelease of norepinephrine from mouse hearts. IV. Structure-activity relationships. Reserpines and yohimbines. (1968) (9)
STRUCTURE–ACTIVITY CORRELATIONS IN TRIHYDROXYPHENETHYLAMINES AND DIHYDROXYTRYPTAMINES RELATIONSHIP TO CYTOTOXICITY IN ADRENERGIC AND SEROTONERGIC NEURONS (1974) (9)
Immunocytochemical localization of catechol-O-methyltransferase in the oviduct and in macrophages in corpora lutea of rat (2004) (8)
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. (1986) (8)
Isolation of the mRNA encoding rat liver catechol-O-methyltransferase. (1989) (8)
General methods for the preparation of deuterium and tritium‐labelled phenethylamines and phenethanollamines: Synthesis of radioactive 6‐hydroxydopamine (1975) (8)
Studies on catechol-O-methyltransferase in rat brain using two-dimensional gel electrophoresis (1986) (8)
The macrophage as a site of extraneuronal uptake and O-methylation of norepinephrine (1993) (7)
Effects on fluorine analogs of norepinephrine on stimulation of cyclic adenosine 3',5'-monophosphate and binding to beta-adrenergic receptors in intact pinealocytes. (1981) (7)
Immunocytochemical localization of aromaticl-amino acid decarboxylase and catechol-O-methyltransferase in blood vessel wall of the human dental pulp (1996) (7)
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity. (1993) (7)
Immunocytochemical Evidence for the Site of O-methylation in Rat Dental Pulp (1991) (7)
Localization of dopamine-beta-oxidase in brain. (1959) (6)
NON-NEURONAL LOCALIZATION OF CATECHOL-O-METHYLTRANSFERASE IN BRAIN (1979) (6)
An enzymatic synthesis of 2-azido-L-tyrosine (1992) (6)
N-(2,4,5-Trihydroxyphenehtyl)normetazocine, a potential irreversible inhibitor of the narcotic receptor. (1977) (6)
Catechol-O-methyltransferase (1993) (5)
Induction of catechol-O-methyltransferase in the luminal epithelium of rat uterus by progesterone: inhibition by RU-486. (1995) (5)
Immunocytochemical localization of catechol-O-methyltransferase of the lymphoid tissue and bone marrow in the rat (1979) (5)
Labile lipophilic derivatives of norepinephrine capable of crossing the blood-brain barrier (1969) (5)
Procaine isothiocyanate: An irreversible inhibitor of the specific binding of [3H]batrachotoxinin-A benzoate to sodium channels (1990) (5)
Incorporation of 2-fluorohistidine in murine protein in vivo. (1992) (4)
Immunocytochemical Evidence for the Coexistence of Catecholestrogen and Catechol-O-methyltransferase in the Rat Parotid Gland (1987) (4)
Reduction of tissue norepinephrine and blood pressure by 3,5-dihydroxy-4-methoxy-phenylalanine. (1968) (4)
O-, N-, and S-methyltransferases (1994) (4)
Immunocytochemical Localization of Catechol-O-Methyltransferase in Rat Parotid Gland (1982) (4)
Anti-catechol-O-methyltransferase: Demonstration of specificity and immunological cross-reactivity with the enzyme from rat liver, kidney, brain, and choroid plexuses (1980) (4)
Reduced COMT activity as a possible environmental risk factor for breast cancer. Opinion (2009) (4)
Voltage-dependent sodium channels in synaptoneurosomes: studies with22Na+ influx and [3H]saxitoxin and [3H]batrachotoxinin-A 20-α-benzoate binding. Effects of proparacaine isothiocyanate (1990) (4)
Batrachotoxinin A [3H]Benzoate Binding to Sodium Channels (1992) (4)
Measurement of DOPA and immunolocalization of l-DOPA-positive nerve fibers in rat dental pulp (1994) (3)
Serotonin, Norepinephrine, and Related Compounds in Bananas. (1958) (3)
Cardiovascular toxicity of dihydroxytryptamines. (1976) (3)
Biochemistry of S-adenosylmethionine and related compounds : proceedings of a conference held at the Lake of the Ozarks (Missouri) on October 26-29, 1981 (1982) (3)
Enzymatic O-methylation of norepinephrine: Studies on the site of methylation by high pressure liquid chromatography (1982) (3)
THE ACTIVATION OF YEAST URIDINEDIPHOSPHOGALACTOSE-4-EPIMERASE BY SPERMINE AND OTHER CATIONS. (1964) (3)
The chemorelease of norepinephrine from mouse hearts. 3. 3,5-Dihydroxy-4-methoxyphenethylamines and related compounds. (1968) (3)
Immunocytochemical localization of catechol-O-methyltransferase in normal and cancerous breast tissues (1982) (3)
Effects of ring fluorination on the adrenergic properties of phenylephrine. (1987) (3)
DRUGS INTERFERING WITH THE FORMATION OF ADRENERGIC TRANSMITTERS (1965) (2)
Reserpine: Interactions with Batrachotoxin and Brevetoxin Sites on Voltage-Dependent Sodium Channels (2002) (2)
Evidence for separation of anesthetic activity from prototypic phencyclidine action in drug discrimination by molecular modification of dioxadrol, a phencyclidine-like dissociative anesthetic. (1984) (2)
Substrates and inhibitors of dopamine-beta-oxidase. (1962) (2)
Estrogen Metabolism: Does the Formation of Estrogen Quinone Provide a Potential Pathway to Breast Carcinogenesis? (2002) (2)
Transmethylation : proceedings of the Conference on Transmethylation, Bethesda, Maryland, U.S.A., on October 16-19, 1978 (1979) (2)
Effect of 2-fluorohistidine upon leukocytopoiesis in mice. (1977) (2)
Archives of the catecholamine club, twenty years on (1989) (1)
SYNTHESES AND ADRENERGIC AGONIST PROPERTIES OF RING-FLUORINATED ISOPROTERENOLS (1982) (1)
Localization of catecholamine degrading enzymes in the rat heart. (1978) (1)
Foreword: Honoring John William Daly (2003) (1)
N-(2,4,5-TRIHYDROXYPHENETHYL)NORMETAZOCINE, A POTENTIAL IRREVERSIBLE INHIBITOR OF THE NARCOTIC RECEPTOR (1977) (1)
Synthesis and Adrenergic Activities of Ring-Fluorinated Analogues of 3- (tert-Butylamino)-2-(3,4-dihydroxyphenyl)-1-propanol. (1993) (1)
SYNTHESIS AND BIOLOGICAL PROPERTIES OF 2-, 5-, AND 6-FLUORONOREPINEPHRINES (1980) (1)
Molecular Orbital Calculations On Catecholamines; Theory and Experiment (1974) (1)
Substrates and inhibitors of dopamine-beta-hydroxylase (DBH). (1965) (1)
Activity and immunocytochemical localization of the catecholamine-synthesizing enzymes in human dental pulp (1997) (1)
Immunocytochemical localization of serotonin, monoamine oxidase and assessment of monoamine oxidase activity in human dental pulp (2000) (1)
Mammalian Alkaloids: O-Methylation of (.+-.)-Norcoclaurine-1-carboxylic Acid and Related Isoquinolines Including (S)- and (R)-Norcoclaurine with 14C-Labeled S-Adenosyl-L-methionine in Presence of Mammalian Catechol O-Methyltransferase (1990) (1)
Phenethylamine isosteres as inhibitors of dopamine beta-oxidase. (1962) (0)
Application of tracer methodology to the study of biogenic amines. (1968) (0)
Mammalian Alkaloids: O-Methylation of (S)- and (R)-Dideoxynorlaudanosoline-1-carboxylic Acid by Catechol O-Methyltransferase and Identification of a Yellow Pigment Obtained at Physiological pH. (1989) (0)
Brain Biochemistry: Cyclic Nucleotides, Phosphorylated Proteins, and Neuronal Function . Paul Greengard. Raven, New York, 1978. x, 124 pp., illus. $12. Distinguished Lecture Series of the Society of General Physiologists, vol. 1. (1979) (0)
Brain biochemistry. (1979) (0)
992 – IMMUNOCHEMICAL STUDIES ON CATECHOL-O-METHYLTRANSFERASE (1977) (0)
Synthesis and Adrenergic Activities of Ring-Fluorinated Analogues of 2- (3,4-Dihydroxyphenyl)morpholine. (1994) (0)
NOREPINEPHRINE UPTAKE SITES IN CARDIAC TISSUE, LACK OF AFFINITY OF 6-HYDROXYNOREPINEPHRINE AND RELATED COMPOUNDS (1975) (0)
INFLUENCE OF FLUORINE SUBSTITUTION ON THE SITE OF ENZYMIC O-METHYLATION OF FLUORINATED NOREPINEPHRINES (1982) (0)
Fluorine substitution of norepinephrine altered affinity for pineal beta adrenergic receptors (1980) (0)
THE CHEMISTRY AND BIOLOGY OF RING-FLUORINATED BIOGENIC AMINES (1984) (0)
Inhibition of leukocytopoesis by 2-fluorohistidine in p388 murine leukemia. Abstr. (1977) (0)
Mammalian Alkaloids: Synthesis and O-Methylation of (S)- and (R)-3′- Hydroxycoclaurine and Their N-Methylated Analogues with S-Adenosyl-L-( methyl-14C)methionine in Presence of Mammalian Catechol O- Methyltransferase. (1992) (0)
Immunohistochemical localization of catechol-O-methyltransferase in brain: potential role as an enzymatic barrier (1981) (0)
Synthesis and Adrenergic Activity of a Semi-Rigid Analogue of 6- Fluoronorepinephrine. (2010) (0)
False Neurochemical Transmitters (2020) (0)
2,4,5-TRIMETHYLPYRROLE-3-CARBOXYLIC ACID ESTERS OF VARIOUS ALKALOIDS (1974) (0)
An Enzymatic Synthesis of 2-Azido-L-tyrosine. (1993) (0)

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