C. Robin Ganellin

C. Robin Ganellin's AcademicInfluence.com Rankings

C. Robin Ganellin

Chemistry

#1281

World Rank

#1964

Historical Rank

Organic Chemistry

#364

World Rank

#431

Historical Rank

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Chemistry

Why Is C. Robin Ganellin Influential?

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According to Wikipedia, Charon Robin Ganellin FRS is a British medicinal chemist, and Emeritus Smith Kline and French Professor of Medicinal Chemistry, at University College London. He has contributed much to the field of drug discovery and development. His most outstanding achievement was the discovery of cimetidine, a drug used to combat stomach ulcers, when he was working at Smith Kline and French. He has received many awards and much recognition for his scientific pursuits over the years. He now lives near London and is a professor at University College London.

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C. Robin Ganellin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Definition and Antagonism of Histamine H2-receptors (1972) (2154)
International Union of Pharmacology. XIII. Classification of histamine receptors. (1997) (894)
High constitutive activity of native H3 receptors regulates histamine neurons in brain (2000) (464)
Histamine and its receptors (2006) (461)
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists. (1988) (457)
Cimetidine—A Non-Thiourea H2-Receptor Antagonist (1975) (429)
Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998) (1998) (400)
Chemical differentiation of histamine H1- and H2-receptor agonists. (1975) (240)
Analogue-based Drug Discovery (2006) (239)
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. (1998) (237)
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H3 Receptor: Preclinical Pharmacology (2007) (215)
Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors (1978) (214)
Pharmacology of Histamine Receptors (1982) (186)
Characterization and inhibition of a cholecystokinin-inactivating serine peptidase (1996) (171)
S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. (1992) (159)
Calcium-activated Potassium Channels Sustain Calcium Signaling in T Lymphocytes (2001) (156)
Distinct pharmacology of rat and human histamine H3 receptors: role of two amino acids in the third transmembrane domain (2000) (150)
Characterization and development of cimetidine as a histamine H2-receptor antagonist (1978) (148)
Protean agonism at histamine H3 receptors in vitro and in vivo (2003) (145)
Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine. (1977) (135)
Sulphur-methylene isosterism in the developent of metiamide, a new histamine H2-receptor antagonist (1974) (129)
Chapter Two – Chemistry and Structure—Activity Relationships of Drugs Acting at Histamine Receptors (1982) (126)
Sedation and histamine H1‐receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene (1991) (116)
Compounds affecting the central nervous system. I. 4-Piperidones and related compounds. (1965) (106)
Glossary of terms used in medicinal chemistry (1998) (103)
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists. (2001) (98)
Molecular Asymmetry of Olefins. I. Resolution of trans-Cyclooctene1-3 (1963) (94)
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel. (2000) (84)
Analogue-based Drug Discovery: FISCHER: ANALOGUE-BASED DRUG DISCOVERY O-BK (2006) (83)
Chapter 36 – Glossary of Terms Used in Medicinal Chemistry (IUPAC Recommendations 1997) (1998) (82)
Synthesis of Potent Non‐imidazole Histamine H3‐Receptor Antagonists (1998) (78)
Bis-quinolinium cyclophanes: 6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca(2+)-activated K+ channel. (1998) (76)
Conformation of histamine derivatives. 3. A relationship between conformation and pharmacological activity. (1973) (68)
Medicinal Chemistry: The Role of Organic Chemistry in Drug Research (1985) (67)
Potential histamine H2-receptor antagonists. 3. Methylhistamines. (1976) (64)
Selective blockers and manipulated channel expression levels (2001) (63)
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. (2002) (61)
Conformation of histamine derivatives. 1. Application of molecular orbital calculations and nuclear magnetic resonance spectroscopy. (1973) (60)
Dictionary of drugs (1990) (59)
Zolantidine (SK&F 95282) is a potent selective brain‐penetrating histamine H2‐receptor antagonist (1988) (58)
Stereochemical studies of chiral H-1 antagonists of histamine: the resolution, chiral analysis, and biological evaluation of four antipodal pairs. (1992) (57)
Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea] —A highly specific histamine H2-receptor agonist. Part 1. Pharmacology (1977) (57)
Molecular features of the prazosin molecule required for activation of Transport-P. (2008) (57)
Conformation of histamine derivatives. 2. Molecular orbital calculations of preferred conformations in relation to dual receptor activity. (1973) (50)
The histamine H3 receptor and its ligands. (2001) (50)
The histamine H2 receptor agonist impromidine: synthesis and structure-activity considerations. (1985) (50)
The tautomer ratio of histamine (1973) (49)
Different antagonist binding properties of human and rat histamine H3 receptors. (2001) (48)
Enhancement of Hippocampal Pyramidal Cell Excitability by the Novel Selective Slow-Afterhyperpolarization Channel Blocker 3-(Triphenylmethylaminomethyl)pyridine (UCL2077) (2006) (48)
Metiamide — An orally active histamine H2-receptor antagonist (1973) (48)
bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel. (2000) (46)
Clotrimazole analogues: effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones (2001) (45)
Characterization and development of cimetidine as a histamine H2-receptor antagonist. (1978) (44)
Discrimination between subtypes of apamin‐sensitive Ca2+‐ activated K+ channels by gallamine and a novel bis‐quaternary quinolinium cyclophane, UCL 1530 (1996) (43)
Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists. (2002) (42)
Proceedings: The pharmacology of cimetidine, a new histamine H2-receptor antagonist. (1975) (41)
Dipole moment in relation to H2 receptor histamine antagonist activity for cimetidine analogues. (1986) (41)
A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists. (1996) (40)
Synthesis and structure-activity relationships of dequalinium analogues as K+ channel blockers. Investigations on the role of the charged heterocycle. (1995) (39)
Predicting the brain-penetrating capability of histaminergic compounds. (1994) (39)
Some chemical aspects of histamine H2-receptor antagonists. (1976) (37)
Refined Docking as a Valuable Tool for Lead Optimization: Application to Histamine H3 Receptor Antagonists (2008) (37)
Resolution of trans-Cycloöctene; Confirmation of the Asymmetry of cis-trans-1,5-Cycloöctadiene (1962) (36)
Correlation between log POCT/H2O and pKB estimates for a series of muscarinic and histamine H2‐receptor antagonists (1988) (36)
Isocytosine H2-receptor histamine antagonists. I: Oxmetidine and related compounds (1988) (35)
Bis‐Quinolinium Cyclophanes: 6,10‐Diaza‐3(1,3),8(1,4)‐dibenzena‐1,5(1,4)‐diquinolinacyclodecaphane (UCL 1684), the First Nanomolar, Non‐Peptidic Blocker of the Apamin‐Sensitive Ca2+‐Activated K+ Channel. (1998) (35)
The Slow Afterhyperpolarization: A Target of β1-Adrenergic Signaling in Hippocampus-Dependent Memory Retrieval (2013) (35)
The pharmacology of cimetidine, a new histamine H2‐receptor antagonist (2010) (35)
[125I]Iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain. (1986) (35)
Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. (2000) (34)
Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). (2008) (32)
2‐(4‐Imidazolyl)ethylammonium bromide (histamine monohydrobromide) (1974) (31)
Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor. (2003) (31)
Compounds that block both intermediate‐conductance (IKCa) and small‐conductance (SKCa) calcium‐activated potassium channels (2000) (31)
Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists. (1975) (31)
Calculation of conformational free energy of histamine (1974) (31)
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. (2003) (29)
Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds. (2003) (29)
Characterization of histamine H1-receptor binding peptides in guinea pig brain using [125I]iodoazidophenpyramine, an irreversible specific photoaffinity probe. (1988) (29)
Histamine H1‐Receptor in Heart: Unique Electrophoretic Mobility and Autoradiographic Localization (1990) (28)
Introduction to biological and small molecule drug research and development : theory and case studies (2013) (27)
Synthesis and quantitative structure-activity relationship of a novel series of small conductance Ca(2+)-activated K+ channel blockers related to dequalinium. (1996) (27)
14 N and 2H quadrupole double resonance in substituted imidazoles (1983) (26)
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity. (1999) (26)
The pharmacology of cimetidine, a new histamine H2-receptor antagonist. (1975) (25)
Metiamide—An orally active histamine H2-receptor antagonist (2005) (25)
An approach to the design of brain-penetrating histaminergic agonists (1993) (24)
Dictionary of drugs: chemical data, structures, and bibliographies (2016) (23)
New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. (2000) (23)
Analogue-Based Drug Discovery II: FISCHER:DRUG ANALOGS II O-BK (2010) (22)
Dictionary of Pharmacological Agents (1996) (21)
Synthesis and quantitative structure-activity relationships of dequalinium analogues as K+ channel blockers: investigation into the role of the substituent at position 4 of the quinoline ring. (1995) (21)
Vocational training for medicinal chemists: views from industry. (1996) (20)
Imetit and N-methyl derivatives. The transition from potent agonist to antagonist at histamine H3 receptors.1 (1992) (19)
Dimaprit, [S-[3-(N,N-dimethylamino)propyl]isothiourea]. A highly specific histamine H2-receptor agonist. Part 2. Structure-activity considerations (1977) (19)
Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. (1999) (19)
Search for the pharmacophore in prazosin for Transport-P. (2005) (19)
Synthesis and pharmacological testing of dequalinium analogues as blockers of the apamin-sensitive Ca(2+)-activated K+ channel: variation of the length of the alkylene chain. (1996) (18)
Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. (2002) (18)
Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists. (2004) (17)
CHEMICAL DIFFERENTIATION OF HISTAMINE H1- AND H2-RECEPTOR AGONISTS (1976) (17)
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. (2000) (17)
Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists. (2002) (17)
Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands (2001) (16)
Synthesis, molecular modeling, and K+ channel-blocking activity of dequalinium analogues having semirigid linkers. (1996) (16)
(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors. (2000) (16)
The dipole moments of 1,3-dimethylthiourea, 1,3-dimethyl-2-cyanoguanidine and 1,1-bis-methylamino-2-nitroethene in a aqueous solution (1982) (16)
Evidence for low brain penetration by the H1-receptor antagonist temelastine (SK&F 93944). (1987) (16)
The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model (2004) (16)
New 3,4-O-isopropylidene derivatives of d- and l-glucopyranosides (1995) (15)
Molecule--receptor specificity. (1975) (15)
Isocytosine H2-receptor histamine antagonists II. Synthesis and evaluation of biological activity at histamine H1- and H2-receptors of 5-(heterocyclyl)methylisocytosines (1989) (15)
Potential HIV protease inhibitors: Preparation of di-N-alkylated 2-, 6-, and 2,6-aminodeoxy-derivatives of d-glucose by direct displacement and by a novel reductive-alkylation procedure (1997) (15)
Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives. (2005) (15)
Analogue-Based Drug Discovery III: FISCHER:DRUG ANALOGS III O-BK (2012) (14)
DNA binding cationic bolasomes with delocalized charge center : A structure-activity relationship study (2001) (14)
Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca(2+)-activated K+ permeability of erythrocytes. (2001) (14)
Naming of substituted histamines (2005) (14)
Photolabile derivatives of 125I-apamin: defining the structural criteria required for labeling high and low molecular mass polypeptides associated with small conductance Ca(2+)-activated K+ channels. (1996) (14)
On the Concept of a Bivalent Pharmacophore for SKCa Channel Blockers: Synthesis, Pharmacological Testing, and Radioligand Binding Studies on Mono‐, Bis‐, and Tris‐quinolinium Compounds (1996) (13)
Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine H1 receptors (1987) (13)
3-[4(5)-Imidazolyl] propylguanidine (SK&F 91486) — a partial agonist at histamine H2-receptors (1975) (12)
Non-basic histamine H1-antagonists. I: Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds (1989) (12)
SULPHUR-METHYLENE ISOSTERISM IN THE DEVELOPMENT OF METIAMIDE, A NEW HISTAMINE H2-RECEPTOR ANTAGONIST (1974) (12)
Crystal and molecular structure of the histamine H2-receptor antagonist N-(4-imidazol-4-ylbutyl)-N′-methylthiourea (burimamide) (1974) (12)
Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013) (2013) (12)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N‐Methyltransferase: ω‐Piperidinoalkanamine Derivatives (2004) (12)
Crystal and molecular structure of the histamine H2-receptor antagonists, N-methyl-N′-{2-[(5-methylimidazol-4-yl)methylthio]ethyl}thiourea (metiamide) and N-{2-[(imidazol-4-yl)methylthio]ethyl}-N′-methylthiourea (thiaburimamide) (1977) (12)
Tritylamino Aromatic Heterocycles and Related Carbinols as Blockers of Ca 2+‐Activated Potassium Ion Channels Underlying Neuronal Hyperpolarization (2002) (12)
Bis-quinolinium cyclophanes: toward a pharmacophore model for the blockade of apamin-sensitive SKCa channels in sympathetic neurons. (2004) (11)
Synthesis of pyridyl isosteres of thioperamide as H3-receptor histamine antagonists (1991) (11)
Icotidine, an antagonist of histamine at both H1 and H2 receptors. (1986) (11)
University education of medicinal chemists: comparison of eight countries. (2000) (11)
CYANOGUANIDINE‐THIOUREA EQUIVALENCE IN THE DEVELOPMENT OF THE HISTAMINE H2‐RECEPTOR ANTAGONIST, CIMETIDINE (1977) (11)
Synthesis and qsar of dequalinium analogues AS K+ channel blockers. investigations on the role of the 4-amino group (1995) (11)
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa) (2007) (11)
Differences in the actions of some blockers of the calcium‐activated potassium permeability in mammalian red cells (1999) (11)
Analogues of Triprolidine: Structural Influences upon Antihistamine Activity (1992) (10)
Inhibition of the antigen-induced activation of RBL-2H3 cells by cetiedil and some of its analogues. (2004) (10)
BF2.649, A NON-IMIDAZOLE INVERSE AGONIST/ANTAGONIST AT THE HUMAN HISTAMINE H3 RECEPTOR: PRECLINICAL PHARMACOLOGY (2006) (10)
Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. (2005) (10)
Education of medicinal chemists in departments of medicinal chemistry (U.S.A.) (1998) (10)
Chemistry and Structure-Activity Relationships of H2-Receptor Antagonists (1978) (10)
Compounds affecting the central nervous system. IV. Substituted 2-benzyl-3-dialkylaminoalkylindenes and related compounds. (1967) (9)
4-(ω-(Alkyloxy)alkyl)-1H-imidazole Derivatives as Histamine H3 Receptor Antagonists/Agonists (2004) (9)
Imidazole Tautomerism of Histamine Derivatives (1974) (9)
Search for the pharmacophore of the K+ channel blocker, apamin (1991) (9)
Relative concentrations of zwitterionic and uncharged species in catecholamines and the effect of N-substituents. (1977) (9)
Indane and indene derivatives of biological interest. (1967) (9)
Relaxation methods applied to engineering problems V. Conformal transformation of a region in plane space (1940) (8)
Abstract: UCL1848: a novel bis-quinolinium cyclophane, which blocks apamin-sensitive K+ channels with nanomolar affinity (1999) (8)
The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro (2004) (8)
Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BK(Ca)). (2006) (8)
636. The tropylium ion. Part V. Synthesis of cyclopropa[1]-phenanthrene derivatives and attempted formation of the dibenzo[a,c]tropylium cation (1959) (8)
OXIDATION OF CYCLOÖCTATETRAENE TO THE TROPYLIUM CATION (1957) (8)
Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. (2004) (7)
Personal reflections on Sir James Black (1924–2010) and histamine (2010) (7)
Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. (2000) (7)
Robin Ganellin gives his views on medicinal chemistry and drug discovery. Interview by Stephen L. Carney. (2004) (7)
Chapter 33. Educating Medicinal Chemists (1995) (7)
Histamine-induced inhibition of lymphocyte proliferation and lysosomal enzyme release from polymorphs may not be mediated via H1- or H2-receptors (1982) (7)
Bis-quinolinium cyclophanes: A novel class of potent blockers of the apamin-sensitive Ca2+-activated K+ channel (1997) (7)
Medicinal chemistry in the development of societies. Biodiversity and natural products. (2000) (6)
The Synthesis and Some Pharmacological Actions of the Enantiomers of the K+‐Channel Blocker Cetiedil (1996) (6)
Zwitterionic analogues of cimetidine as H2 receptor antagonists. (1987) (6)
Chapter 10 Histamine Receptors (1979) (6)
Radiosynthesis and biodistribution of two potential antagonists of cerebral histamine H3 receptors for PET studies: [18F]FUB 272 and [11C]UCL 1829 (1998) (6)
The dielectric properties of seven polar amidine-containing compounds of biological interest (1985) (6)
Synthesis of Potent Non‐Imidazole Histamine H3‐Receptor Antagonists. (1999) (5)
Defining determinant molecular properties for the blockade of the apamin-sensitive SKCa channel in guinea-pig hepatocytes: the influence of polarizability and molecular geometry. (2004) (5)
Aminoalkylation of metal derivatives of indole. Part III. Alkylation of lithio-derivatives of N-substituted indoles with 1-chloro-2-dimethylaminoethane (1969) (5)
112. Rearrangements of some cyclooctatetraene derivatives (1958) (5)
Isocytosine H2-receptor histamine antagonists. IV. The synthesis and biological activity of donetidine (SK&F 93574) and related compounds (1993) (5)
The synthesis of 1-substituted-2-( -dimethylaminoethyl)benzimidazoles (1966) (5)
Discovery of the Antiulcer Drug Tagamet (2006) (5)
Dipole moment in relation to hydrogen receptor histamine antagonist activity for cimetidine analogs (1986) (4)
Chemical constitution and prototropic equilibria in structure — activity analysis (1977) (4)
Polyclonal and monoclonal antibodies directed against SK & F 94461, a specific H1 histamine receptor ligand. (1988) (4)
Discovery of Pitolisant, the First Marketed Histamine H3‐Receptor Inverse Agonist/Antagonist for Treating Narcolepsy* (2018) (4)
Two‐dimensional NMR analysis of selected dequalinium analogues having aralkyl linking groups (1998) (4)
Dimaprit, [S-[3-(N,N-dimethylamino)propyl]isothiourea]. A highly specific histamine H2-receptor agonist. Part 2. Structure-activity considerations (2005) (4)
12. The tropylium ion. Part III. Oxidation of cyclohepta-2 : 4 : 6-trienecarboxylic acid (1958) (4)
Structures of histamine H1-receptor antagonists derived from the cimetidine group of histamine H2-receptor antagonists. (1994) (3)
An Approach to the Design of Brain‐Penetrating Histaminergic Agonists. (1993) (3)
Partial Structures of Ketoconazole as Modulators of the Large Conductance Calcium‐Activated Potassium Channel (BKCa). (2006) (3)
Aminoalkylation of metal derivatives of indole. Part II. Coupling of indolylmagnesium iodides with halogenoalkylamines (1967) (3)
Synthesis of Pyridyl Isosteres of Thioperamide as H3-Receptor Histamine Antagonists. (1992) (3)
Structure-activity studies with histamine H3-receptor ligands. (1995) (3)
Design of an Affinity Matrix for Purification of the Histamine H1 Receptor from Guinea Pig Cerebellum (1992) (3)
Constitutive activity of the recombinant and native histamine H3 receptor (2003) (3)
Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity. (2000) (3)
ANTIHISTAMINIC DIFFERENCES BETWEEN THE ENANTIOMERS OF DIMETHINDENE (1990) (3)
An Efficient New Synthesis of Racemic Cetiedil and a Novel Route to α-Ketocarboxylic Acids Utilising Mild Conditions (2007) (3)
The synthesis of tertiary arylalkylamines from aryl Grignard reagents. (1966) (3)
Structure-activity studies of pyridinylalkyl-isocytosine H1-receptor antihistamines and identification of an active conformation. (1991) (3)
Discovery of the cholesterol absorption inhibitor, ezetimibe (2013) (3)
Dimaprit—[S-[3-(N,N-dimethylamino)propyl]isothiourea]—A highly specific histamine H2-receptor agonist. Part 1, pharmacology (2005) (3)
Inhibition of amine oxidases by analogues of the substrates, histamine and putrescine (1985) (2)
Optimizing Drug Therapy by Analogues (2010) (2)
Cimetidine and Other Histamine H 2 -Receptor Antagonists (1987) (2)
Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (2)
Calculations on Unstable Conformations of Histamine and Methylhistamines (1974) (2)
Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels. (2013) (2)
LEAD GENERATION (2023) (2)
Compounds affecting the central nervous system. V. Substituted 3-dialkylaminoalkylindenes. (1969) (2)
Chemical data, structures and bibliographies (1990) (2)
The pressor activity of burimamide: A relationship between chemical constitution and pressor activity of burimamide and related histamine H2-receptor antagonists (1977) (2)
Development of Anti‐Ulcer H2‐Receptor Histamine Antagonists (2006) (1)
Potent Partial Agonists for the Histamine H3 Receptor Lacking a Nitrogen Atom in the Side Chain (2002) (1)
The “homologisation” of phenanthrene by diazomethane (1964) (1)
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists. (2004) (1)
ChemInform Abstract: Tritylamino Aromatic Heterocycles and Related Carbinols as Blockers of Ca2+-Activated Potassium Ion Channels Underlying Neuronal Hyperpolarization. (2002) (1)
Synthesis and Authentication of Iodoazidophenpyramine, a Photoaffinity Reporter Ligand Previously used for Histamine H1‐Receptor Labelling (1995) (1)
Education of Medicinal Chemists in Departments of Medicinal Chemistry (USA) (1998) (1)
The Histamine H2Receptor Agonist Impromidine: Synthesis and Structure-Activity Considerations. (1986) (1)
Substituted N-phenylcarbamates as histamine H3 receptor antagonists with improved in vivo potency. (2000) (1)
Histamine H3 receptors : novel ligands and responses (1992) (1)
N-Methyldimaprit (SK&F92054). A chemical control for the histamine H2-receptor agonist dimaprit (1986) (1)
Tautomerism of 4-methylhistamine—Effect of the methyl substituent (1979) (1)
Chapter Twenty-Four - Glossary of Terms Used in Medicinal Chemistry Part II (IUPAC Recommendations 2013) (2013) (1)
SC10 Design of non-thiourea H3-receptor histamine antagonists (1994) (0)
BF2.649 Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H 3 Receptor: Preclinical Pharmacology (2006) (0)
Partial agonists for the histamine H3 receptor with high in vivo activity (2001) (0)
Past approaches to discovering new medicines (1995) (0)
Comprar Dictionary of Drugs on CD-ROM | David J. Triggle | 9780412787607 | Informa Healthcare (2007) (0)
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)). (2007) (0)
News guanidines, method of preparing them and their applications (1976) (0)
Foerfarande Foer framstaellning of the therapeutically active heterocyclic urea eller tioureafoereningar (1972) (0)
Alkylamino derivatives, their salts, processes for their production and these compounds containing drug (1976) (0)
Peptidase inhibitors tripeptidyl. (1998) (0)
Method of preparation of perfect cyanoghanidines and products obtained (1975) (0)
Frontiers in histamine research : a tribute to Heinz Schild : based on an international symposium held at Jouy-en-Josas (near Paris), France, 25-27 July 1984 (1985) (0)
PharmaSource (CD-ROM) Dictionary of Pharmacological Agents plus the PDR Generics (1997) (0)
Use of histamine derivatives for producing drugs, new histamine derivatives and drugs. (1992) (0)
Anomalous product from the benzylation of phenylacetonitrile (1969) (0)
NITROGEN-14 AND DEUTERIUM QUADRUPOLE DOUBLE RESONANCE IN SUBSTITUTED IMIDAZOLES (1983) (0)
Isocytosine H2-Receptor Histamine Antagonists. Part 1. Oxmetidine and Related Compounds. (1988) (0)
Compounds containing Michael acceptor, in particular, maleiimi-imide, or maleic acid derivatives, and which is tied to the chromophore and the use of long duration, auringonestokoostumuksissa (1996) (0)
CONFORMATION OF HISTAMINE DERIVATIVES PART 5, MOLECULAR ORBITAL CALCULATION OF THE H1-RECEPTOR ′ESSENTIAL′ CONFORMATION OF HISTAMINE (1975) (0)
Non-imidazolalkylaminer as histamine H 3 receptor and the therapeutic uses thereof (1999) (0)
The use of histamine derivatives for fremtilling of drugs, novel histamine derivatives and pharmaceutical (1992) (0)
New 3,4‐O‐Isopropylidene Derivatives of D‐ and L‐Glucopyranosides. (1996) (0)
S.16.04 Histamine H3-receptor ligands: Effects of inverse agonists and protean ligands (2003) (0)
Professor C. Robin Ganellin FRS (2001) (0)
1,1-diaminoaethylenderivate, their salts, processes for their production and drug (1974) (0)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N-Methyltransferase: w-Piperidinoalkanamine (2004) (0)
Medicinal chemistry graduate school curriculum and contribution to pharmaceutical industry in Japan (1998) (0)
Design of protease inhibitors from structures of substrate products. The example of butabindide, an inhibitor of the cholecystokinin (CCK-8)-inactivating peptidase (1997) (0)
Pioneer and Analogue Drugs (2012) (0)
The Ingenuity of Medicinal Chemists in a Century of Progress for Central Nervous System Medicaments (2001) (0)
CONFORMATION OF HISTAMINE DERIVATIVES PART 3, A RELATIONSHIP BETWEEN CONFORMATION AND PHARMACOLOGICAL ACTIVITY (1973) (0)
Structures of nine histamine H2 antagonists related to N-cyano-N'-methyl-N-[4-(2-pyridyl)butyl]guanidine (1993) (0)
P.1.03 Constitutive activity of the recombinant and native histamine H3 receptor: effects of inverse agonists and protean agonists (2004) (0)
Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands. (2001) (0)
Method for the preparation of pyrimidine compounds (1976) (0)
489. The tropylium ion. Part IV. Conversion of cyclohepta-2,4,6-trienecarboxylic acid into tropylium salts (1959) (0)
Structural properties of group B ligands for transport-P (2002) (0)
Iso-thio-ureas and derivatives (1971) (0)
An Efficient New Synthesis of Racemic Cetiedil and a Novel Route to α-Ketocarboxylic Acids Utilizing Mild Conditions (2007) (0)
Pyrimid-4-one and -thione derivatives, their salts with acids, processes for their preparation and pharmaceutical compositions containing these compounds (1976) (0)
Medicinal Chemistry as a Scientific Discipline in Industry and Academia: Personal Reflections (2007) (0)
Therapeutic use as histamine H3 receptor ligands of alkyl amines which do not contain imidazoles (1999) (0)
Cyanoguanidines, their salts, processes for their production and these compounds containing drug (1973) (0)
Modulation of GABAA receptors and inhibitory synaptic currents in cultured rat cortical neurones by the endogenous brain lipid cis-9,10-octadecenoamide (cOA) (1997) (0)
Non-Basic Histamine H1-Antagonists. Part 1. Synthesis and Biological Evaluation of Some Substituted 2-(2-Pyridylaminoalkylamino)pyrimidones and Related Compounds. (1989) (0)
New imidazole derivatives, their preparation and their therapeutic applications. (1993) (0)
Synthesis and Authentication of Iodoazidophenpyramine, a Photoaffinity Reporter Ligand Previously Used for Histamine H1-Receptor Labelling. (1996) (0)
Thioureas and thiocarbamates, process for preparing them and pharmaceutical compositions containing them (1976) (0)
Letter: Calculation of conformational free energy of histamine. (1974) (0)
Educating Chemists for Medicinal Chemistry (2006) (0)
Urea derivatives, their salts with acids, processes for their production and these drug compounds containing (1976) (0)
Isohistamine [2-(2-aminoethyl)imidazole] (1968) (0)
Cyclobutendion- and -dithionderivate, their salts with acids, processes for their manufacture and medicaments containing these compounds (1976) (0)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N-Methyltransferase: ω-Piperidinoalkanamine Derivatives. (2005) (0)
Compounds containing a Michael acceptor, in particular, maleimide or maleic acid derivatives, directly or indirectly bound to the (1995) (0)
Research and training in medical chemistry in south and central american countries and sub-saharan Africa (1997) (0)
Two routes to becoming a medicinal chemist (2001) (0)
News pyrimidones, their method of preparing and applying therapeutic (1976) (0)
Design of potent non-imidazole histamine H3-receptor antagonists (2003) (0)
News cyclobut-1-ene-3,4-diones, their process for the preparation and implementation (1976) (0)
CONFORMATION OF HISTAMINE DERIVATIVES PART 1, APPLICATION OF MOLECULAR ORBITAL CALCULATIONS AND NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (1973) (0)
Medicial chemistry in the development of societies. Biodiversity and natural products (2000) (0)
News guanidines, their process for the preparation and implementation (1976) (0)
Guanidine and thiourea, their process for the preparation and implementation (1976) (0)
Inhibitors of tripeptidilpeptidasa. (1996) (0)
WHO on drug safety. (1969) (0)
Histamine receptors in GtoPdb v.2021.3 (2021) (0)
Potential HIV Protease Inhibitors: Preparation of Di-N-alkylated 2-, 6- , and 2,6-Aminodeoxy-Derivatives of D-Glucose by Direct Displacement and by a Novel Reductive-Alkylation Procedure. (1997) (0)
Isocytosine H2‐Receptor Histamine Antagonists. Part 4. Synthesis and Biological Activity of Donetidine (SKPF 93574) and Related Compounds. (1994) (0)
The discovery of potent non-imidazole H3-receptor histamine antagonists (2001) (0)
Analogifremgangsmaade for the preparation of urea derivatives containing an imidazolyl group (1976) (0)
Bis-quinolinium Cyclophanes: A Novel Class of Potent Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel. (1997) (0)
Potential histamine H2-receptor antagonists. 4. Benzylhistamines. (1982) (0)
CRYSTAL AMD MOLECULAR STRUCTURE OF THE HISTAMINE H2-RECEPTOR ANTAGONISTS, N-METHYL-N′-(2-((5-METHYLIMIDAZOL-4-YL)METHYLTHIO)ETHYL)THIOUREA (METIAMIDE) AND N-(2-((IMIDAZOL-4-YL)METHYLTHIO)ETHYL)-N′-METHYLTHIOUREA (THIABURIMAMIDE) (1977) (0)
Compounds containing a Michael acceptor system, preferably maleimide or maleic acid derivatives, which is linked directly or indirectly with a chromophoric group and their use in sunscreen compositions with long lasting protection (1995) (0)
New imidazole derivatives, their preparation and therapeutic uses (1993) (0)
Amines and their salts, processes for their production and drug (1974) (0)
New derivatives of imidazole, their preparation and their therapeutic applications. (1992) (0)
POTENTIAL HISTAMINE H2-RECEPTOR ANTAGONISTS. 3. METHYLHISTAMINES (1976) (0)
Blocking histamine H2-receptors with imidazolylalkyl guanidine derivatives (1982) (0)

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