C. Ronald Kahn | Academic Influence

C. Ronald Kahn's AcademicInfluence.com Rankings

C. Ronald Kahn

Philosophy

#1343

World Rank

#2474

Historical Rank

#541

USA Rank

Logic

#190

World Rank

#425

Historical Rank

#88

USA Rank

philosophy Degrees

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Philosophy

C. Ronald Kahn's Degrees

Doctorate Medicine University of Louisville
PhD Biochemistry University of Louisville

Why Is C. Ronald Kahn Influential?

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According to Wikipedia, Carl Ronald Kahn is an American physician and scientist, best known for his work with insulin receptors and insulin resistance in diabetes and obesity. He is the Chief Academic Officer at Joslin Diabetes Center, the Mary K. Iacocca Professor of Medicine at Harvard Medical School and a member of the National Academy of Sciences since 1999.

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C. Ronald Kahn's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Insulin signalling and the regulation of glucose and lipid metabolism (2001) (4964)
Identification and importance of brown adipose tissue in adult humans. (2009) (3803)
Critical nodes in signalling pathways: insights into insulin action (2006) (2613)
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 (2003) (1989)
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 (2001) (1845)
The insulin signaling system. (1994) (1654)
Suppression of Aging in Mice by the Hormone Klotho (2005) (1618)
Type 2 diabetes mellitus (2015) (1613)
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein (1991) (1486)
Developmental Origin of Fat: Tracking Obesity to Its Source (2007) (1409)
Antioxidants prevent health-promoting effects of physical exercise in humans (2009) (1401)
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue (2003) (1304)
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (1994) (1285)
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes (1999) (1162)
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation (1994) (1120)
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. (2000) (1118)
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. (1990) (1092)
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. (1976) (1021)
Insulin receptor signaling in normal and insulin-resistant states. (2014) (1007)
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction (2000) (952)
Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues (2017) (943)
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. (1982) (924)
Insulin action and the insulin signaling network. (1995) (897)
Insulin Action, Diabetogenes, and the Cause of Type II Diabetes (1994) (889)
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. (1999) (870)
Role of brain insulin receptor in control of body weight and reproduction. (2006) (859)
SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (2010) (834)
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure (2008) (825)
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. (2002) (792)
Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. (1978) (789)
Phlorizin: a review (2005) (778)
SIRT3 regulates fatty acid oxidation via reversible enzyme deacetylation (2009) (766)
From mice to men: insights into the insulin resistance syndromes. (2006) (727)
Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. (1987) (707)
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance (2000) (702)
Diabetes primes neutrophils to undergo NETosis, which impairs wound healing (2015) (698)
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. (2011) (671)
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms (2004) (661)
A guide to analysis of mouse energy metabolism (2011) (641)
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. (2007) (638)
Beneficial effects of subcutaneous fat transplantation on metabolism. (2008) (631)
Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways (2002) (608)
Evidence for a role of developmental genes in the origin of obesity and body fat distribution. (2006) (593)
The changing natural history of nephropathy in type I diabetes. (1985) (590)
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells (1985) (564)
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. (1998) (562)
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles (1997) (559)
Cellular bioenergetics as a target for obesity therapy (2010) (525)
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system (1982) (518)
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. (2000) (513)
Bidirectional modulation of insulin action by amino acids. (1998) (511)
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014) (470)
Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. (1985) (467)
Membrane receptors for hormones and neurotransmitters (1976) (456)
Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes (2005) (447)
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. (2007) (445)
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. (2003) (437)
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. (2008) (436)
Epidemiologic approach to the etiology of type I diabetes mellitus and its complications. (1987) (435)
Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. (1997) (432)
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression (1999) (432)
Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome. (2015) (425)
Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis (2002) (425)
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease (2016) (420)
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production (2011) (413)
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. (2002) (398)
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance (1975) (397)
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. (1988) (393)
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. (1976) (391)
Cross-talk between the insulin and angiotensin signaling systems. (1996) (391)
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways (2013) (389)
The insulin receptor and the molecular mechanism of insulin action. (1988) (389)
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. (2004) (388)
Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes (2007) (386)
Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline (2012) (381)
Insulin signaling to the glomerular podocyte is critical for normal kidney function. (2010) (373)
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. (2012) (372)
The molecular mechanism of insulin action. (1985) (370)
Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. (1973) (366)
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease. (2019) (362)
Role for neuronal insulin resistance in neurodegenerative diseases (2004) (354)
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. (2011) (351)
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. (1993) (347)
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. (1992) (345)
β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass (2002) (340)
Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity (1988) (339)
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. (1978) (338)
Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability (2016) (337)
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. (2000) (336)
Endocrine regulation of ageing (2007) (333)
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. (2003) (331)
Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism (2009) (325)
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 (2012) (322)
The cellular fate of glucose and its relevance in type 2 diabetes. (2004) (320)
Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. (1995) (316)
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α (2000) (313)
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. (1997) (311)
Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease (2012) (311)
The emerging genetic architecture of type 2 diabetes. (2008) (308)
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. (2006) (308)
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. (1974) (307)
Expression and function of IRS-1 in insulin signal transmission. (1992) (307)
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. (2005) (302)
Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor. (1980) (301)
Transplantation of adipose tissue and stem cells: role in metabolism and disease (2010) (300)
Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. (1993) (300)
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. (1982) (299)
Lessons on Conditional Gene Targeting in Mouse Adipose Tissue (2013) (293)
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice (2007) (293)
Cold but not sympathomimetics activates human brown adipose tissue in vivo (2012) (290)
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders (2015) (289)
Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival (2002) (288)
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. (2001) (281)
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. (1988) (279)
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. (2006) (278)
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. (2010) (272)
Role for neuronal insulin resistance in neurodegenerative diseases. (2004) (269)
Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots (2012) (268)
Hepatic insulin resistance directly promotes formation of cholesterol gallstones (2008) (264)
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. (2019) (264)
Dissection of the insulin signaling pathway via quantitative phosphoproteomics (2008) (261)
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. (1999) (257)
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. (2002) (256)
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. (2004) (256)
Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase (2001) (256)
Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophy (2002) (254)
Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. (1978) (253)
Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism (2011) (252)
Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. (2004) (250)
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. (1992) (248)
Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes (2006) (247)
Insulin receptor deficiency in genetic and acquired obesity. (1975) (247)
Mir193b–365 is essential for brown fat differentiation (2011) (247)
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. (1996) (245)
Insulin receptor knockout mice. (2003) (243)
Genetics of non-insulin-dependent (type-II) diabetes mellitus. (1996) (243)
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus. (1993) (240)
Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes (2005) (237)
Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels. (1983) (237)
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. (2005) (236)
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy (2010) (235)
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. (1999) (235)
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. (2005) (232)
Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. (1985) (232)
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin (2005) (229)
4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice (*) (1995) (229)
Role of microRNA processing in adipose tissue in stress defense and longevity. (2012) (226)
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. (1983) (226)
Mouse models of insulin resistance. (2002) (223)
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells (1997) (222)
Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation (2013) (220)
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation. (2000) (218)
Brown fat as a therapy for obesity and diabetes (2010) (217)
Akt Signaling Mediates Postnatal Heart Growth in Response to Insulin and Nutritional Status* (2002) (217)
Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. (2003) (215)
Central insulin action regulates peripheral glucose and fat metabolism in mice. (2008) (215)
Interplay between FGF21 and insulin action in the liver regulates metabolism. (2014) (214)
Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. (1995) (214)
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. (2003) (214)
Erratum: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (Nature (1994) 372 (186-190)) (1994) (210)
Receptors, antireceptor antibodies and mechanisms of insulin resistance. (1979) (210)
Differences in Risk of Insulin-Dependent Diabetes in Offspring of Diabetic Mothers and Diabetic Fathers (1984) (209)
Brown fat as a therapy for obesity and diabetes (2010) (208)
Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. (2001) (208)
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. (2012) (206)
Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action. (1977) (206)
Risk of Proliferative Diabetic Retinopathy in Juvenile-Onset Type I Diabetes: A 40-yr Follow-up Study (1986) (205)
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. (2000) (204)
Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3 (2006) (204)
Tissue-specific Ablation of the GLUT4 Glucose Transporter or the Insulin Receptor Challenges Assumptions about Insulin Action and Glucose Homeostasis* (2003) (203)
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. (2003) (203)
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. (2004) (201)
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia (2003) (199)
Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance (2004) (198)
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. (2002) (196)
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling (2017) (196)
Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. (1976) (196)
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. (1984) (194)
Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. (2010) (191)
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue (2012) (189)
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. (2010) (188)
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. (2001) (187)
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure (2009) (186)
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response (2010) (180)
The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor. (1982) (180)
Unraveling the mechanism of action of thiazolidinediones. (2000) (179)
MIRO: Microwave Instrument for Rosetta Orbiter (2007) (175)
Dynamics of Insulin Signaling in 3T3-L1 Adipocytes (1998) (174)
Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells* (2000) (172)
Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins. (1996) (172)
Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man. (1975) (171)
Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes* (2000) (171)
Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man. (1975) (168)
Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice (2002) (166)
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits. (1983) (164)
Ectopic production of chorionic gonadotropin and its subunits by islet-cell tumors. A specific marker for malignancy. (1977) (164)
Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells. (1985) (164)
ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes (2014) (164)
The role of insulin and IGF-1 signaling in longevity (2005) (163)
Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation (2004) (163)
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization (2015) (163)
Adipose Depots Possess Unique Developmental Gene Signatures (2010) (162)
Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. (2000) (161)
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. (1981) (161)
Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture. (1978) (160)
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus. (1991) (159)
Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice (2004) (158)
The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing. (1978) (157)
Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN (2006) (156)
Human corneal epithelial primary cultures and cell lines with extended life span: in vitro model for ocular studies. (1993) (156)
Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase. (1991) (155)
Maintenance of 3T3-L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin action. (1981) (155)
Evidence for a circulating islet cell growth factor in insulin-resistant states (2001) (155)
Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain (1996) (155)
Essential Role of Insulin and Insulin-Like Growth Factor 1 Receptor Signaling in Cardiac Development and Function (2006) (155)
The insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself. (1979) (155)
A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species (2013) (155)
Metabolically healthy and unhealthy obese – the 2013 Stock Conference report (2014) (154)
Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system. (1983) (151)
Acromegaly and cardiovascular disorders. A prospective study. (1974) (150)
Insulin receptors, receptor antibodies, and the mechanism of insulin action. (1981) (148)
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. (2006) (148)
Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. (2004) (148)
Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess* (2005) (148)
Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay. (1974) (147)
Thermoneutral housing exacerbates non-alcoholic fatty liver disease in mice and allows for sex-independent disease modeling (2017) (146)
Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. (1984) (145)
Crosstalk between insulin and angiotensin II signalling systems. (2009) (145)
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. (2014) (144)
Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling* (2003) (143)
MicroRNA sequence codes for small extracellular vesicle release and cellular retention (2021) (143)
Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. (2010) (142)
Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes (2007) (142)
Diabetes and insulin in regulation of brain cholesterol metabolism. (2010) (142)
Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse (1972) (141)
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat‐specific insulin receptor knock‐out mice (2007) (141)
The insulin resistance of acromegaly: evidence for two alterations in the insulin receptor on circulating monocytes. (1979) (139)
Divergent roles of growth factors in the GnRH regulation of puberty in mice. (2010) (138)
Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism (2018) (137)
The Insulin Receptor - A Critical Link in Glucose Homeostasis and Insulin Action (1998) (136)
Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites. (2018) (134)
Targeted Elimination of Peroxisome Proliferator-Activated Receptor γ in β Cells Leads to Abnormalities in Islet Mass without Compromising Glucose Homeostasis (2003) (134)
Insulin and Insulin-like Growth Factor-1 Receptors Act as Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription* (2010) (133)
Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit (2000) (133)
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. (1988) (132)
Immunologic Reactions to Insulin: Insulin Allergy, Insulin Resistance, and the Autoimmune Insulin Syndrome (1979) (131)
Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action. (2002) (131)
Role of insulin receptors in insulin-resistant states. (1980) (130)
Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins. (1988) (129)
125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. (1978) (128)
Overexpression of Rad Inhibits Glucose Uptake in Cultured Muscle and Fat Cells* (1996) (128)
Non-parallel evolution of metabolic and growth-promoting functions of insulin (1981) (128)
Role of Foxa-2 in adipocyte metabolism and differentiation. (2003) (127)
Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function. (1992) (127)
Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance. (1984) (126)
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. (1992) (125)
Characterization of the insulin receptor kinase purified from human placental membranes. (1983) (125)
Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets (2009) (125)
ATP induces a conformational change of the 90-kDa heat shock protein (hsp90). (1993) (124)
Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications (2014) (124)
Bioessays news and reviews in molecular, cellular and developmental biology (2002) (123)
Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. (2010) (123)
Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors. (1975) (123)
Amino acid deficiency and the skin rash associated with glucagonoma. (1979) (123)
The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity. (1991) (123)
Role of Insulin Action and Cell Size on Protein Expression Patterns in Adipocytes* (2004) (122)
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. (2002) (122)
Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. (1981) (122)
High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. (1991) (122)
Adiponectin: linking the fat cell to insulin sensitivity (2003) (121)
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. (2006) (121)
Acquired defect in interleukin-2 production in patients with type I diabetes mellitus. (1986) (121)
Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus. (1995) (120)
Insulin regulates astrocyte gliotransmission and modulates behavior (2018) (120)
Impaired Thermogenesis and Adipose Tissue Development in Mice with Fat-Specific Disruption of Insulin and IGF-1 Signalling (2012) (119)
New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it. (2012) (119)
Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome (2016) (118)
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. (2004) (117)
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. (2003) (117)
Antibiotic effects on gut microbiota and metabolism are host dependent. (2016) (117)
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. (2010) (116)
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. (2004) (114)
Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. (2005) (114)
Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. (1990) (114)
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. (2011) (114)
The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. (1975) (113)
The evolving clinical course of patients with insulin receptor autoantibodies: spontaneous remission or receptor proliferation with hypoglycemia. (1978) (112)
Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis. (2015) (111)
Crucial role of the small GTPase Rac1 in insulin‐stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma (2010) (111)
Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro. (1985) (110)
SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling. (2013) (110)
Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism (2017) (110)
Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis (2017) (109)
Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior (2019) (108)
Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization (1993) (108)
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. (1999) (107)
In vivo andin vitro studies of vanadate in human and rodent diabetes mellitus (1995) (106)
Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance (2010) (106)
Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts. (1979) (105)
The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies. (1992) (105)
Leptin Suppresses Stearoyl-CoA Desaturase 1 by Mechanisms Independent of Insulin and Sterol Regulatory Element–Binding Protein-1c (2006) (105)
Characterization of an endogenous substrate of the insulin receptor in cultured cells. (1987) (104)
Differential Roles of Insulin Receptor Substrates in the Anti-apoptotic Function of Insulin-like Growth Factor-1 and Insulin* (2002) (104)
Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. (2019) (104)
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. (2016) (104)
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. (2003) (103)
Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. (2005) (103)
Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling (2001) (103)
Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: evidence for a postreceptor defect. (1978) (102)
The Surface of Mars: The View from the Viking 2 Lander (1976) (102)
Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease (2003) (102)
Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis* (2003) (101)
Differential Roles of the Insulin and Insulin-like Growth Factor-I (IGF-I) Receptors in Response to Insulin and IGF-I*[boxs] (2004) (101)
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. (2013) (101)
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance (2008) (99)
Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats. (1989) (98)
Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin. (1985) (98)
Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. (2003) (98)
Glucocorticoid-induced insulin resistance in vitro: evidence for both receptor and postreceptor defects. (1981) (98)
Genetically Programmed Selective Islet β-Cell Loss in Diabetic Subjects With Wolfram's Syndrome (1989) (97)
Putting the genes for type II diabetes on the map (2001) (97)
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. (2010) (97)
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. (1993) (96)
The riddle of tumour hypoglycaemia revisited. (1980) (95)
Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function (2016) (95)
Thymic lymphocytes in obese (ob-ob) mice. A mirror of the insulin receptor defect in liver and fat. (1974) (95)
Hypoglycemia associated with non-islet-cell tumor and insulin-like growth factors. (1981) (95)
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. (2007) (95)
Insulin and non-suppressible insulin-like activity (NSILA-s): evidence for separate plasma membrane receptor sites. (1974) (93)
Rad and Rad-related GTPases Interact with Calmodulin and Calmodulin-dependent Protein Kinase II* (1997) (93)
Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23. (2001) (93)
Receptors for peptide hormones. New insights into the pathophysiology of disease states in man. (1977) (93)
Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance. (1973) (92)
Altered Insulin Signaling in Retinal Tissue in Diabetic States* (2004) (92)
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism (2018) (92)
Characterization of the receptors for insulin and the insulin-like growth factors on micro- and macrovascular tissues. (1985) (92)
Intrinsic Heterogeneity in Adipose Tissue of Fat-specific Insulin Receptor Knock-out Mice Is Associated with Differences in Patterns of Gene Expression* (2004) (91)
Membrane Receptors for Polypeptide Hormones (1975) (91)
Regulation of insulin receptors in normal and abnormal physiology in humans. (1979) (91)
Processing of Insulin by Bovine Endothelial Cells in Culture: Internalization Without Degradation (1984) (90)
Immunoprecipitation of the insulin receptor: a sensitive assay for receptor antibodies and a specific technique for receptor purification. (1979) (90)
The insulin receptor and its substrate: molecular determinants of early events in insulin action. (1993) (90)
p50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity (2004) (90)
FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy (2018) (89)
The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. (1997) (89)
Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging (2013) (89)
Characterization of the insulin receptor in its membrane environment by radiation inactivation. (1980) (89)
Insulin receptor defect in insulin resistance: studies in the obese-hyperglycimic mouse. (1972) (89)
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance (2002) (88)
Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin. (1984) (88)
Prevalence of mutations in AGPAT2 among human lipodystrophies. (2003) (88)
Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine (2012) (87)
Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia (2006) (87)
Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD (2016) (87)
Cosmological perturbations in inflationary-universe models (1984) (87)
Streptozotocin for malignant insulinomas and carcinoid tumor. Report of eight cases and review of the literature. (1973) (86)
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. (2003) (86)
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression (2017) (86)
TRB3 Blocks Adipocyte Differentiation through the Inhibition of C/EBPβ Transcriptional Activity (2007) (86)
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. (2000) (86)
Anatomical and Functional Assessment of Brown Adipose Tissue by Magnetic Resonance Imaging (2012) (85)
Cosmological perturbations in the early universe (1983) (85)
Causes of insulin resistance (1995) (85)
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. (2009) (84)
Pancreatic cholera: benefical effects of treatment with streptozotocin. (1975) (84)
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. (2019) (84)
Insulin binding and insulin-dependent phosphorylation of the insulin receptor solubilized from human erythrocytes. (1983) (84)
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes. (1993) (84)
The role and importance of brown adipose tissue in energy homeostasis (2010) (84)
Insulin enhances glucose-stimulated insulin secretion in healthy humans (2010) (83)
Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation. (2007) (83)
The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth. (1990) (82)
The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. (2011) (82)
Circulating NSILA-s in man: Preliminary studies of stimuli in vivo and of binding to plasma components. (1975) (81)
Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. (2017) (81)
Rad GTPase Deficiency Leads to Cardiac Hypertrophy (2007) (80)
Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor (2008) (80)
Insulin Receptor Substrate Proteins Create a Link between the Tyrosine Phosphorylation Cascade and the Ca2+-ATPases in Muscle and Heart* (1997) (80)
A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation. (1994) (79)
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance (2013) (79)
Fructose and hepatic insulin resistance (2020) (78)
Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells* (2008) (78)
Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression. (1997) (78)
Cell culture studies on patients with extreme insulin resistance. I. Receptor defects on cultured fibroblasts. (1982) (78)
Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice (2017) (78)
Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity. (1984) (77)
Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro. (2002) (77)
The p85α Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance (2007) (77)
Insulin Stimulation of Phosphorylation of the Subunit of the Insulin Receptor (1982) (76)
Antireceptor antibodies as probes of insulinlike growth factor receptor structure. (1983) (76)
Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes. (1981) (75)
A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis (2010) (75)
Joslinʼs Diabetes Mellitus (1995) (75)
Insulin receptor phosphorylation in intact adipocytes and in a cell-free system. (1982) (74)
Human Insulin Receptor Substrate-1 (IRS-1) Polymorphism G972R Causes IRS-1 to Associate with the Insulin Receptor and Inhibit Receptor Autophosphorylation* (2005) (74)
A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease (2010) (73)
Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction (2016) (73)
Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats. (1992) (72)
Intracellular binding sites for insulin are immunologically distinct from those on the plasma membrane (1977) (72)
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. (1990) (71)
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration (2011) (71)
The development of insulin receptors and responsiveness is an early marker of differentiation in the muscle cell line L6. (1986) (70)
Cross-talk between Insulin and Wnt Signaling in Preadipocytes (2012) (69)
High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice* (2007) (69)
Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. (1983) (69)
Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death (2008) (68)
Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells. (1989) (68)
Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes. (1977) (67)
CDK4 is an essential insulin effector in adipocytes. (2016) (67)
Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice. (1999) (67)
Insulin inhibition of antibody-dependent cytoxicity and insulin receptors in macrophages (1977) (67)
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism (2015) (66)
Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity. (1976) (66)
Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase (1993) (66)
Protein-tyrosine Phosphatase 1B Deficiency Reduces Insulin Resistance and the Diabetic Phenotype in Mice with Polygenic Insulin Resistance* (2007) (65)
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. (2003) (65)
Determinants of IDDM and Perinatal Mortality in Children of Diabetic Mothers (1988) (65)
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms (2005) (65)
Developmental and functional heterogeneity of white adipocytes within a single fat depot (2018) (65)
Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver. (1988) (64)
Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture. (1979) (64)
Insulin-induced Up-regulated Uncoupling Protein-1 Expression Is Mediated by Insulin Receptor Substrate 1 through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Fetal Brown Adipocytes* (2003) (64)
Treatment by plasma exchange of a patient with autoantibodies to the insulin receptor. (1979) (64)
Insulin-receptor antibodies mimic a late insulin effect (1979) (64)
Characterization of Binding and Phosphorylation Defects of Erythrocyte Insulin Receptors in the Type A Syndrome of Insulin Resistance (1986) (63)
Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone. (1994) (63)
Adrenocortical carcinoma and hypoglycemia: evidence for production of nonsuppressible insulin-like activity by the tumor. (1977) (63)
Bi-directional Regulation of Brown Fat Adipogenesis by the Insulin Receptor* (2003) (63)
Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose. (1989) (63)
Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes. (1982) (62)
SIRT 3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011) (62)
Rad, a Novel Ras-related GTPase, Interacts with Skeletal Muscle β-Tropomyosin (*) (1996) (61)
Two steps of insulin receptor internalization depend on different domains of the beta-subunit [published erratum appears in J Cell Biol 1993 Nov;123(4):1047] (1993) (61)
Phosphorylation of the insulin receptor in cultured hepatoma cells and a solubilized system. (1985) (61)
Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance (2009) (61)
Insulin resistance: a common feature of diabetes mellitus. (1986) (60)
Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes. (2002) (59)
Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. (2003) (59)
Multichordal charge exchange recombination spectroscopy on the Doublet III tokamak (1986) (58)
The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells. (1990) (58)
Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor. (1976) (58)
Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function (2013) (58)
Head and trunk neural crest in vitro: autonomic neuron differentiation. (1980) (57)
MiR-193b-365, a brown fat enriched microRNA cluster, is essential for brown fat differentiation (2011) (57)
Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo. (2019) (57)
Defining the underlying defect in insulin action in type 2 diabetes (2021) (57)
Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes (1980) (57)
Knockout Mice Challenge our Concepts of Glucose Homeostasis and the Pathogenesis of Diabetes (2003) (57)
Characterization of Rad, a New Member of Ras/GTPase Superfamily, and Its Regulation by a Unique GTPase-activating protein (GAP)-like Activity (*) (1995) (56)
p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. (2004) (56)
Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates. (2006) (56)
The insulin receptor of the turkey erythrocyte: similarity to mammalian insulin receptors. (1977) (56)
Muscle-Specific Deletion of the Glut4 Glucose Transporter Alters Multiple Regulatory Steps in Glycogen Metabolism (2005) (55)
β-Cell Hyperplasia Induced by Hepatic Insulin Resistance (2009) (55)
Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans (2012) (55)
Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody. (1979) (55)
The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate (1979) (55)
Loss of Akt1 in Mice Increases Energy Expenditure and Protects against Diet-Induced Obesity (2011) (55)
Rad GTPase Attenuates Vascular Lesion Formation by Inhibition of Vascular Smooth Muscle Cell Migration (2005) (54)
Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. (2004) (53)
Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform. (2009) (52)
A regime of improved energy confinement in beam-heated expanded-boundary discharges in Doublet III (1985) (51)
Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells. (1989) (51)
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis (2020) (51)
Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells. (1995) (50)
Insulin action at a molecular level – 100 years of progress (2021) (50)
Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies. (1989) (50)
Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. (1976) (50)
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions (2018) (50)
HNFs--Linking the Liver and Pancreatic Islets in Diabetes (2004) (50)
Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice (2016) (49)
Demonstration of a primary (? genetic) defect in insulin receptors in fibroblasts from a patient with the syndrome of insulin resistance and acanthosis nigricans type A. (1980) (49)
Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. (2003) (49)
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (1994) (49)
An arginine to cysteine252 mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events (2002) (49)
Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues. (1987) (49)
Regulation of endocytic-transcytotic pathways and bile secretion by phosphatidylinositol 3-kinase in rats. (1997) (48)
Mitochondrial proton leak in obesity-resistant and obesity-prone mice. (2007) (48)
Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes. (1994) (48)
Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice? (2000) (48)
Picking a research problem. The critical decision. (1994) (48)
7 The Insulin Receptor and Tyrosine Phosphorylation (1986) (47)
Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice. (1999) (47)
Autophosphorylation and kinase activity of insulin receptor in diabetic rats. (1986) (47)
Insulin's discovery: New insights on its ninetieth birthday (2012) (47)
Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1. (1993) (46)
FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism (2019) (46)
Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells: Concomitant Changes in Receptor Number and in Binding Affinity (1984) (46)
Analysis of insulin action using differentiated and dedifferentiated hepatoma cells. (1983) (46)
Gab-1-mediated IGF-1 Signaling in IRS-1-deficient 3T3 Fibroblasts* (2000) (46)
Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase (1987) (46)
PI3-kinase mutation linked to insulin and growth factor resistance in vivo. (2016) (46)
Insulin stimulates p70 S6 kinase in the nucleus of cells. (1997) (45)
Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. (2002) (45)
Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes (2014) (44)
Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function (2016) (44)
Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α* (2003) (44)
Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. (2013) (44)
Cascade of autophosphorylation in the β‐subunit of the insulin receptor (1989) (44)
Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation. (1985) (44)
The insulin receptor of the turkey erythrocyte. Characterization of the membrane-bound receptor. (1976) (43)
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes. (2020) (43)
Monoclonal antibodies to the major Lolium perenne (rye grass) pollen allergen Lol p I (Rye I). (1986) (42)
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level. (2006) (42)
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. (2009) (42)
Berson, Yalow, and the JCI: the agony and the ecstasy. (2004) (42)
Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells. (1989) (42)
Region‐specific mRNA expression of phosphatidylinositol 3‐kinase regulatory isoforms in the central nervous system of C57BL/6J mice (1999) (42)
Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function. (1979) (42)
Molecular determinants of insulin action. (1993) (41)
Hepatocyte Stress Increases Expression of Yes‐Associated Protein and Transcriptional Coactivator With PDZ‐Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis (2020) (41)
Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei. (1993) (41)
The Role of Insulin Receptors and Receptor Antibodies in States of Altered Insulin Action (1979) (40)
Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice. (2004) (40)
Postnatal Growth Responses to Insulin-Like Growth Factor I in Insulin Receptor Substrate-1-Deficient Mice1. (1999) (40)
Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier. (2004) (40)
The human erythrocyte insulin-like growth factor I receptor: characterization and demonstration of ligand-stimulated autophosphorylation. (1986) (40)
Insulin-Receptor Gene and Its Expression in Patients With Insulin Resistance (1989) (40)
Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients. (2016) (39)
Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction. (1992) (39)
Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. (1992) (39)
Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity (1987) (39)
The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system (1996) (39)
Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes. (1994) (39)
Association of Insulin Receptor Substrate 1 (IRS-1) Y895 with Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis (2001) (39)
Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation (2010) (38)
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus (1996) (38)
Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans (1980) (38)
Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells (2014) (38)
Hepatocyte Stress Increases Expression of YAP and TAZ in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis. (2019) (38)
Mosaic analysis of insulin receptor function. (2004) (37)
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose (2018) (37)
The ras-related protein rad associates with the cytoskeleton in a non-lipid-dependent manner. (1998) (37)
Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. (1989) (37)
Insulin receptor regulation and desensitization in rat hepatoma cells. The loss of the oligomeric forms of the receptor correlates with the change in receptor affinity. (1984) (37)
Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance (2016) (36)
Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors* (2011) (36)
Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes (1997) (36)
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of b1-integrin and phosphatidylinositol 3-kinase/AKT signaling beta. (2003) (36)
Cell culture studies on patients with extreme insulin resistance. II. Abnormal biological responses in cultured fibroblasts. (1982) (36)
Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone (2014) (36)
Insulin receptors and the molecular mechanism of insulin action. (1985) (36)
Metabolic syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance? (2011) (36)
Cell membrane receptors for polypeptide hormones. Application to the study of disease states in mice, and men. (1975) (36)
Phosphorylation of insulin-like growth factor I receptor by insulin receptor tyrosine kinase in intact cultured skeletal muscle cells. (1988) (36)
Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases. (1989) (36)
Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display. (1998) (36)
The role of pancreatic venous sampling in the localization of occult insulinomas. (1981) (36)
Molecular scanning of the insulin receptor substrate.1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms (1996) (35)
Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts. (1980) (35)
Interaction of the insulin receptor kinase with serine/threonine kinases in vitro (1985) (35)
Shox2 is a molecular determinant of depot-specific adipocyte function (2013) (35)
An association between NIDDM and a GAA trinucleotide repeat polymorphism in the X25/frataxin (Friedreich's ataxia) gene. (1998) (35)
Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. (2018) (35)
Cellular Compartmentalization in Insulin Action: Altered Signaling by a Lipid-Modified IRS-1 (2000) (34)
Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization. (1988) (34)
Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity (2017) (34)
Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain (2019) (33)
Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes. (2002) (33)
Autoantibodies to insulin receptors (1981) (33)
Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line (1984) (33)
Radioreceptor assay of insulin: Comparison of plasma and pancreatic insulins and proinsulins. (1975) (33)
Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1. (1994) (33)
Short-lived cytoplasmic regulators of gene expression in cell cybrids (1981) (33)
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. (2018) (33)
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α (2002) (32)
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. (2012) (32)
Regional differences in brain glucose metabolism determined by imaging mass spectrometry (2018) (32)
Demonstration by radiation inactivation that insulin alters the structure of the insulin receptor in rat liver membranes. (1981) (32)
Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism (2015) (32)
Characterization and regulation of the mouse insulin receptor substrate gene promoter. (1995) (32)
A patient with type B insulin resistance syndrome, responsive to immune therapy (2007) (31)
The underlying insulin receptor in patients with antireceptor autoantibodies: demonstration of normal binding and immunological properties. (1979) (31)
Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. (2011) (31)
Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. (1992) (31)
Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor (2017) (31)
Triglycerides and toggling the tummy (2000) (31)
What is the molecular basis for the action of insulin (1979) (31)
Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells. (1989) (31)
Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. (1993) (31)
The Branch Point Enzyme of the Mevalonate Pathway for Protein Prenylation Is Overexpressed in theob/ob Mouse and Induced by Adipogenesis (2000) (31)
Observation of very dense and cold divertor plasma in the beam-heated Doublet III tokamak with single-null poloidal divertor (1984) (31)
Defects in insulin binding and autophosphorylation of erythrocyte insulin receptors in patients with syndromes of severe insulin resistance and their parents. (1987) (30)
Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. (2016) (29)
Thioesterase Superfamily Member 2/Acyl-CoA Thioesterase 13 (Them2/Acot13) Regulates Adaptive Thermogenesis in Mice* (2013) (29)
Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes (1993) (29)
White Adipose Tissue (2012) (29)
Molecular determinants of insulin action. (1993) (29)
Cultured quail neural crest cells attain competence for terminal differentiation into melanocytes before competence to terminal differentiation into adrenergic neurons. (1983) (29)
Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes. (1988) (29)
Effects of phosphorylation on function of the Rad GTPase. (1998) (29)
Ammonium inhibits processing and cytotoxicity of reovirus, a nonenveloped virus. (1986) (29)
Characterization of a membrane regulator of insulin receptor affinity. (1983) (28)
Can We Nip Obesity in Its Vascular Bud? (2008) (28)
Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process. (1991) (28)
Role of the Transmembrane Domain and Flanking Amino Acids in Internalization and Down-regulation of the Insulin Receptor * (1995) (28)
Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice (2010) (27)
Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms (2004) (27)
Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome. (1989) (26)
Effect of Cholesterol Reduction on Receptor Signaling in Neurons* (2015) (26)
Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system. (1997) (26)
Alterations in insulin receptor and substrate phosphorylation in hypertensive rats. (1992) (26)
Trinucleotide Repeats at the rad Locus: Allele Distributions in NIDDM and Mapping to a 3-cM Region on Chromosome 16q (1995) (26)
Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity (2020) (26)
Altered expression and function of the insulin receptor in a family with lipoatrophic diabetes. (1988) (26)
Properties and partial purification of the detergent-solubilized insulin receptor: a demonstration of negative cooperativity in micellar solution. (1978) (25)
Effect of cholesterol reduction on receptor signaling in neurons. (2016) (25)
Mitochondria, obesity and aging (2012) (25)
The insulin receptor gene and its expression in insulin-resistant mice. (1988) (25)
Computer-aided detection of diffuse liver disease in ultrasound images. (1992) (24)
Magnetization transfer imaging of the abdomen at 0.1 T: detection of hepatic neoplasms. (1993) (24)
Diabetes. Causes of insulin resistance. (1995) (24)
The Insulin Receptor Protein Kinase (1985) (24)
Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2014) (24)
Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver (2020) (24)
Hawking radiation in an inflationary universe (1982) (23)
Divertor studies in high-power beam heated discharges in Doublet-III (1984) (23)
Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism (2022) (23)
Specific plasma membrane receptors for reovirus on rat pituitary cells in culture. (1983) (23)
Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase. (1991) (23)
A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor. (1994) (23)
Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan (2017) (22)
Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth (2019) (22)
"White Paper" meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. (2016) (22)
Identification and high yield purification of insulin-like growth factors (nonsuppressible insulin-like activities and somatomedins) from human plasma by use of endogenous binding proteins. (1979) (22)
Molecular defects in insulin action. (1989) (22)
p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis (2014) (22)
Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin (2020) (22)
Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain–Liver Connection (2016) (22)
Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. (2017) (22)
Transcriptional and posttranscriptional regulation of tyrosine aminotransferase by insulin in rat hepatoma cells. (1988) (22)
PI 3-kinase regulatory subunits as regulators of the unfolded protein response. (2011) (22)
Insulin Resistance in Vascular Endothelial Cells Promotes Intestinal Tumor Formation (2017) (22)
Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor. (1983) (22)
Diabetes in ageing: pathways for developing the evidence base for clinical guidance. (2020) (22)
Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle (2001) (22)
Use of somatostatin and somatostatin analogs in a patient with a glucagonoma. (1981) (21)
Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans. (2000) (21)
Different Pathways of Postreceptor Desensitization following Chronic Insulin Treatment and in Cells Overexpressing Constitutively Active Insulin Receptors* (1996) (21)
Analysis of mRNA heterogeneity by ribonuclease H mapping: application to the insulin receptor. (1989) (21)
Viral Hormones: Expanding Dimensions in Endocrinology. (2019) (21)
Hormonal regulation of the affinity and concentration of hormone receptors in target cells. (1976) (21)
Synthesis and characterization of molecular hybrids of insulin and insulin-like growth factor I. The role of the A-chain extension peptide. (1982) (21)
Insulin Activates Glycogen Synthase in Cultured Human Fibroblasts (1980) (21)
SOCS-1 deficiency does not prevent diet-induced insulin resistance. (2008) (21)
Atypical β-adrenergic effects on insulin signaling and action in β3-adrenoceptor-deficient brown adipocytes (2002) (20)
Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes. (2004) (20)
Coordinate Phosphorylation of Insulin-Receptor Kinase and Its 175,000-Mr Endogenous Substrate in Rat Hepatocytes (1991) (20)
Signal transducer and activator of transcription 3 and the phosphatidylinositol 3‐kinase regulatory subunits p55α and p50α regulate autophagy in vivo (2014) (20)
Differing effects of antiinsulin serum and antiinsulin receptor serum on 123I-insulin metabolism in rats. (1985) (19)
Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice. (1994) (19)
Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young) (2013) (19)
In vitro lymphocyte proliferation response to therapeutic insulin components. Evidence for genetic control by the human major histocompatibility complex. (1983) (19)
A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes (2022) (19)
TRPV1 neurons regulate β-cell function in a sex-dependent manner (2018) (19)
Isolation of plasma membranes for cell surface membrane receptor studies. (1974) (19)
Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains (2021) (18)
Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats. (1988) (18)
The Immune Response to Insulin in Man: Interaction of HLA Alloantigens and the Development of the Immune Response (1982) (18)
Differentiation-dependent phosphorylation of a 175,000 molecular weight protein in response to insulin and insulin-like growth factor-I in L6 skeletal muscle cells. (1989) (18)
Effects of insulin-sensitising agents in mice with hepatic insulin resistance (2004) (18)
Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes. (2017) (17)
Development of an in vitro reconstitution assay for glucose transporter 4 translocation. (1999) (17)
Genetic models of Insulin Resistance:Alterations in β-cell biology (2001) (17)
Dietary Carbohydrate, a Big Mac, and Insulin Requirements in Type I Diabetes (1988) (17)
Adipose-derived circulating miRNAs regulate gene expression in other tissues (2017) (17)
Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism (2019) (17)
Insulin induces the phosphorylation of DNA-binding nuclear proteins including lamins in 3T3-F442A. (1992) (17)
The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases. (1994) (17)
Virus-induced decrease of insulin receptors in cultured human cells. (1980) (17)
Characterization of phosphatidylinositol kinase activity associated with the insulin receptor. (1986) (16)
Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes (2019) (16)
Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity. (1987) (16)
Pyruvate induces torpor in obese mice (2018) (16)
Quantitative dissociation between EGF effects on c‐myc and c‐fos gene expression, DNA synthesis, and epidermal growth factor receptor tyrosine kinase activity (1992) (16)
Glucagon resistance of hepatoma cells. Evidence for receptor and post-receptor defects. (1983) (16)
Insulin Action in the Brain and the Pathogenesis of Alzheimer’s Disease (2010) (16)
Adriamycin therapy for advanced insulinoma. (1977) (16)
Fatty liver disease: is it nonalcoholic fatty liver disease or obesity-associated fatty liver disease? (2019) (16)
Suppression of catecholamine and melanin synthesis and promotion of cholinergic differentiation of quail neural crest cells by heart cell conditioned medium. (1982) (16)
Heat flux to the limiter during disruptions and neutral beam injection in Doublet-III (1984) (15)
Congenital hypothyroidism in a young man with growth hormone, thyrotropin, and prolactin deficiencies. (1976) (15)
Severe insulin resistance alters metabolism in mesenchymal progenitor cells. (2015) (15)
Photoreactive Insulin Derivatives: Comparison of Biologic Activity and Labeling Properties of Three Analogues in Isolated Rat Adipocytes (1982) (15)
Insulin-like growth factor-mediated phosphorylation and protooncogene induction in Madin-Darby canine kidney cells. (1991) (15)
Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids (2018) (15)
Coordinate roles of insulin and glucose on the growth of hepatoma cells in culture. (1986) (15)
Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease (2018) (15)
Macromolecular lactic acid dehydrogenase. A cause of increased serum lactate dehydrogenase activity. (1974) (15)
T-cell vaccination in experimental myasthenia gravis: a double-edged sword. (1990) (14)
The immunology of the insulin receptor. (1976) (14)
Insulin Receptors in Disease States (1979) (14)
Diabetes: a strategic plan for the 21st century. (1999) (14)
Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation. (1976) (14)
The Insulin Receptor Tyrosine Kinase (1990) (14)
Insulin and epidermal growth factor stimulate phosphorylation of a 170-kDa protein in intact hepatocytes immunologically related to lipocortin 1. (1988) (14)
Receptor Antibodies as Novel Therapeutics for Diabetes (2011) (14)
Letter: Insulin activity: the solid matrix. (1973) (14)
The Circulating Proinsulin-like Components (1972) (14)
Extracellular miRNAs as mediators of obesity‐associated disease (2021) (14)
Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle (1978) (14)
Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes (1997) (14)
Thyroid cancer after radioactive iodine diagnostic procedures in childhood. (1973) (13)
Transmembrane domain inversion blocks ER release and insulin receptor signaling. (1995) (13)
Initial processing of the insulin receptor precursor in vivo and in vitro. (1988) (13)
Effects of Heparin on Insulin Binding and Biological Activity (1987) (13)
Modulation of expression of insulin and IGF‐I receptor by Epstein‐Barr virus and its gene products LMP and EBNA‐2 in lymphocyte cell lines (1993) (13)
Insulin: A pacesetter for the shape of modern biomedical science and the Nobel Prize (2021) (13)
8 – Effect of Insulin on Growth in Vivo and Cells in Culture (1985) (13)
Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. (2016) (13)
Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP (1996) (13)
Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes (2018) (13)
Common and Distinct Elements in Insulin and PDGF Signaling a (1995) (13)
Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes (2019) (13)
Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle. (2008) (13)
Autoantibodies to insulin receptors in man: immunological determinants and mechanism of action. (1982) (13)
Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells. (1991) (13)
Plasma proinsulin-like components. (1974) (12)
Role of valence and the cytoskeleton in the insulin‐like activity of concanavalin A (1981) (12)
The PI3K regulatory subunits p55α and p50α regulate cell death in vivo (2014) (12)
Comprehensive Search for Novel Circulating miRNAs and Axon Guidance Pathway Proteins Associated with Risk of ESKD in Diabetes (2021) (12)
Insulin Induces the Phosphorylation of Nucleolin (1993) (12)
Lack of a simple relationship between endogenous growth hormone and NSILA-s related peptides. (1977) (12)
Insulin receptor messenger ribonucleic acid sequence alterations detected by ribonuclease cleavage in patients with syndromes of insulin resistance. (1989) (12)
IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance. (2007) (12)
Persistent infection with a nontransforming RNA virus leads to impaired growth factor receptors and response (1986) (12)
Erratum: Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse (Proceedings of the National Academy of Sciences of the United States of America (July 13, 2004) 101, 28 (10422-10427)) (2005) (11)
Application of radioreceptor assay to circulating insulin, growth hormone, and to their tissue receptors in animals and man. (1973) (11)
A family of polypeptide substrates and inhibitors of insulin receptor kinase. (1990) (11)
Circumscribing or periadenomal vessel: a helpful angiographic finding in certain islet cell and parathyroid adenomas. (1981) (11)
Molecular Scanning of β-3-Adrenergic Receptor Gene in Total Congenital Lipoatrophic Diabetes Mellitus (1997) (11)
The Phosphoinositide 3-Kinase Regulatory Subunit p85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2010) (11)
The molecular mechanism of insulin action and the regulation of glucose and lipid metabolism (2011) (11)
Developmental Origin of Fat: Tracking Obesity to Its Source (2008) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens (2021) (11)
Identification and Importance of Brown Adipose Tissue in Adult Humans (2009) (11)
4 f -spin dynamics in La 2 − x − y Sr x Nd y CuO 4 (1999) (11)
Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. (2019) (11)
Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes. (2002) (11)
25 Analysis of grass Group I allergens using monoclonal antibodies (1983) (10)
Visualization of the Insulin Receptor by Immunoblotting (1984) (10)
miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation. (2021) (10)
Male Brown Fat–Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity (2018) (10)
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice. (2003) (10)
New concepts in the pathogenesis of diabetes mellitus. (1996) (10)
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise (2020) (10)
Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase (2017) (10)
Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization (2015) (10)
Autoantibodies to the insulin receptor: clinical significance and experimental applications. (1980) (9)
Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance (2020) (9)
Interplay between FGF21 and insulin action in the liver regulates metabolism. (2015) (9)
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism (2019) (9)
Differential effects of viral infection on islet and pituitary cell lines. (1985) (9)
Microwave Instrument for the Rosetta Orbiter (MIRO) (1999) (9)
Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains. (1990) (9)
EFFECTS OF STARVATION, REFEEDING, AND DIETING (1976) (9)
Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of 1-Integrin and Phosphatidylinositol 3-Kinase / AKT Signaling 1 (2003) (9)
Hormone resistance and hormone sensitivity. (1977) (9)
Autoimmunity and the aetiology of insulin-dependent diabetes mellitus (1982) (8)
Vanadium Salts in the Treatment of Human Diabetes Mellitus (1998) (8)
Synthesis and Characterization of Molecular Hybrids of Insulin and Insulin-like Growth Factor I (1982) (8)
Transfer of heritable properties by cell cybridization: Specificity and the role of selective pressure (1981) (8)
Membrane receptors and cellular regulation (1984) (8)
Ephs and ephrins keep pancreatic Beta cells connected. (2007) (8)
Molecular defects in the insulin receptor in patients with leprechaunism and in their parents. (1989) (8)
Ephs and Ephrins Keep Pancreatic β Cells Connected (2007) (8)
Signaling defects associated with insulin resistance in non-diabetic and diabetic individuals and modification by sex. (2021) (8)
Receptors for insulin and insulin-like growth factors in disease. (1980) (8)
Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle. (2001) (8)
Insulin allergy and insulin resistance. (1994) (8)
Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature. (2021) (8)
New concepts in the pathogenesis of diabetes mellitus. (1996) (7)
Autoantibodies to the insulin receptor: clinical and molecular aspects. (1979) (7)
Insulin receptors and syndromes of insulin resistance. (1982) (7)
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs). (1988) (7)
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis (DOI:10.1016/j.cmet.2006.02.010) (2006) (7)
Inhibition of the PI 3‐kinase pathway disrupts the unfolded protein response and reduces sensitivity to ER stress‐dependent apoptosis (2020) (7)
Asc-1, PAT2 and P2RX5 are novel cell surface markers for white, beige and brown adipocytes (2015) (7)
Insulin receptors and syndromes of insulin resistance. (1982) (7)
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice. (2003) (7)
Fluctuations in Models With Primordial Inflation (1984) (7)
Bi-directional regulation of brown fat adipogenesis by the insulin receptor. (2016) (7)
The insulin receptor goes nuclear (2019) (7)
Glucagon regulation of amino acid transport in hepatocytes: Effect of cell enucleation (1983) (7)
Autoantibodies to the insulin receptor: clinical and molecular aspects. (1979) (7)
Insulin action on metabolism (1997) (7)
Insulin action in the brain: cell types, circuits, and diseases (2022) (7)
Chronic hyperinsulinemia promotes human hepatocyte senescence (2022) (6)
Diabetes: a strategic plan for the 21st century (1999) (6)
Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes. (1990) (6)
Radioactive labeling and turnover studies of the insulin receptor subunits. (1985) (6)
Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice (2020) (6)
Autoantibodies to the insulin receptor and insulin-resistant diabetes. (1982) (6)
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. (2016) (6)
The Joslin Diabetes Center (2000) (6)
The role of obesity in diabetes mellitus (1996) (6)
Perverted priorities. The physician/scientist as spokesman and salesman for biomedical research. Presidential address to the American Society for Clinical Investigation, Washington, DC, 29 April 1989. (1989) (6)
Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue. (2021) (6)
Analysis of the insulin receptor by anti-receptor antibodies and flow cytometry. (1984) (6)
Langmuir probe measurements in beam-heated divertor discharges in D-III (1984) (6)
Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes (1978) (6)
Proximal tubular epithelial insulin receptor mediates high-fat diet–induced kidney injury (2021) (6)
The Phosphoinositide 3-Kinase Regulatory Subunit p 85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2011) (6)
Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways (2021) (6)
Interactions between insulin and the cyclic AMP system of Cloudman S91 mouse melanoma cells (1983) (6)
The insulin receptor: characterization and regulation using insulin-antiinsulin antibody complexes as a probe for flow cytometry. (1985) (5)
SPECIAL CLASSES FOR EMOTIONALLY DISTURBED CHILDREN. (1964) (5)
The binding of insulin to mouse leucocytes during viral infections (1983) (5)
Specific Deletion of Insulin Receptors on Pancreatic Acinar Cells Defines the Insulin-Acinar Axis: Implications for Pancreatic Insufficiency in Diabetes (2011) (5)
Subunit structure of the insulin receptor of the human lymphocyte. (1980) (5)
Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60src (1984) (5)
A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor (2021) (5)
Plasma Membrane Insulin Receptor Regulation by Genetic, Metabolic, and Hormonal Factors (1974) (5)
The scaling of edge properties with main plasma parameters in doublet III discharges (1984) (5)
“100 Years of progress in understanding insulin, its mechanism of action, and its roles in disease and diabetes therapy” (2021) (5)
Effect of dexamethasone on the carbohydrate chains of the insulin receptor. (1994) (5)
Divertor and edge plasma properties in doublet III expanded boundary discharges (1986) (5)
Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis (2011) (5)
Pathways of insulin degradation in isolated adipocytes: evaluation by gel filtration and differential precipitation. (1985) (5)
Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5). (2016) (5)
Insulin action on metabolism (1997) (4)
Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling (2017) (4)
Insulin activation of glycogen synthase in cultured human fibroblasts is not mediated solely via the insulin receptor. (1986) (4)
Characterization of viral insulins reveals white adipose tissue-specific effects in mice (2020) (4)
Molecular scanning of beta-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus. (1997) (4)
Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study. (1995) (4)
Sirt2 Regulates Adipocyte Differentiation Involving FoxO1 Acetylation/Deacetylation (2007) (4)
[Characterization of the IRS-1 (insulin receptor substrate-1) gene and its promoter]. (1994) (4)
Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors (2018) (4)
938-P: A Human Gut Commensal, Parabacteroides Distasonis, Enhances Type 1 Diabetes Autoimmunity via Molecular Mimicry (2020) (4)
Cross-talk between insulin and angiotensin signaling (1996) (4)
CHAPTER 5 – Antibodies to the Insulin Receptor: Studies of Receptor Structure and Function (1984) (4)
Further evidence for a 2π+2π−1.7 GeV/c2 enhancement observed in the pp → 3π+3π−πo reaction at 5.7 GeV/c (1971) (4)
Rosalyn Sussman Yalow (1921–2011) (2012) (4)
Insulin radioreceptor assay on murine splenic leukocytes and peripheral erythrocytes. (1982) (4)
Abstract 260: Loss of Insulin Signaling in Vascular Endothelium Accelerates Atherosclerosis in Apolipoprotein E Knockout Mice (2006) (3)
Augmented desensitization to epidermal growth factor (EGF) immediate actions: A novel mechanism for altered EGF growth response in mutant A431 cells (1990) (3)
Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors (2022) (3)
Modulation of the insulin receptor by insulin receptor autoantibodies. (1980) (3)
Erratum: Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism (Journal of Clinical Investigation (2005) 115 (718-727) DOI: 10.1172/JCI200523187) (2005) (3)
Identification of Cross Reactive Insulin Immunogenic Epitopes from Commensal Gut Microbes (2018) (3)
[B22-D-arginine]insulin: synthesis and biological properties. (1982) (3)
A proposed new role for the insurance industry in biomedical research funding. (1984) (3)
[B17-D-leucine]insulin and [B17-norleucine]insulin: synthesis and biological properties. (1983) (3)
Insulin-dependent phosphatidylinositol 3'-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells. (1995) (3)
Cell Metabolism: Why, and why now? (2005) (3)
On means of varying conditions in the expanded boundary divertor without affecting energy confinement (1984) (3)
Sirt5 Plays a Critical Role in Mitochondrial Protein Acylation and Mitochondrial Metabolic Homeostasis in Brown Fat (2018) (3)
Prevalence of Mutations in AGPAT2 Among Human (2003) (3)
Insulin Receptor Substrate-l (IRS-I) Distribution in the Rat Central Nervous System (1994) (3)
Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients (1982) (3)
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling (2022) (3)
The use of infrared dichroic absorption spectra in the study of the structure of bovine fibrinogen and fibrin. (1970) (3)
Analysis of insulin receptors on human lymphoblastoid cell lines by flow cytometry (1984) (3)
Radioactive labeling and turnover studies of the insulin receptor subunits. (1985) (3)
Gut Microbiota Regulate Pancreatic Growth, Exocrine Function and Gut Hormones. (2022) (3)
Correction for Taniguchi et al., Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN (2016) (3)
The PI3K regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signalling (2011) (3)
Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats (1990) (2)
High Baseline Vitamin C Levels Do Not Prevent a Positive Outcome of a Lifestyle Intervention (2010) (2)
Power flow in neutral beam-heated limiter discharges in the D-III tokamak (1984) (2)
Cysteine 647 in the Insulin Receptor Is Required for Normal Covalent Interaction between a- and @-Subunits and Signal Transduction* (2001) (2)
Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist (2022) (2)
[Conditional mutagenesis--second generation knockout mice as models for internal diseases]. (1999) (2)
The effect of a single blade limiter on energetic neutral beam particles in doublet III (1984) (2)
Effect of cross-linking agents on insulin associated responses in adipocytes. (1982) (2)
Leptin therapy for type 1 diabetes gains traction (2010) (2)
Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity (2017) (2)
Conditions promoting creativity in group rearing of children. (1974) (2)
MON-100 Unique miRNA Signature in HIV Lipodystrophy with Reduced Adipose Dicer Expression (2019) (2)
Insulin binding and activation of glycogen synthase in fibroblasts from type 1 (insulin-dependent) diabetic patients (1982) (2)
QUANTITATIVE ANALYSIS OF LIVER TEXTURE IN ULTRASOUND IMAGES (1990) (2)
Effect of cross-linking agents on insulin associated responses in adipocytes. (1982) (2)
Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity. (2017) (2)
Health care reform--need for less emotion and more science. (2009) (2)
Turning on Brown Fat and Muscle Metabolism: Hedging Your Bets (2012) (2)
P2F-9 A Novel Model for Contrast Enhanced Ultrasound Video and Its Applications (2006) (2)
Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly (2018) (2)
Three-dimensional visualization of the liver from computed-tomography data (1990) (2)
Expression of insulin receptors and insulin action in cell hybrids and cybrids. (1983) (1)
Parabacteroides distasonis insulin B:9-23 epitope mimic stimulates insulin specific T-cells and enhances Type 1 Diabetes in NOD mice (2020) (1)
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice (2022) (1)
Crazy All the Time: On The Psych Ward of Bellevue Hospital (1994) (1)
Observation of the d * Effect in the p̄d-->pp̄π + π - n Reaction at 5.55 GeVc (1971) (1)
Multi-Omic Profiling Reveals the Opposing Forces of Excess Dietary Sugar and Fat on Liver Mitochondria Protein Acetylation and Succinylation (2018) (1)
Explorer Deficiency of PDK 1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia (2017) (1)
Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling (2022) (1)
Response to Comment on Ussar et al. Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes 2017;66:886–896 (2017) (1)
Approaches to the molecular cloning of protein-tyrosine phosphatases in insulin-sensitive tissues (1992) (1)
O-24: A common amino acid polymorphism in IRS-1 causes impaired insulin signaling: Evidence from transfection studies (2009) (1)
Defects in Early Insulin Signaling in Skeletal Muscle (2002) (1)
Erratum: Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ (Cell Metabolism (2006) 3 (343-353)) (2016) (1)
Small-angle elastic scattering of antiprotons at 3 GeV/c in nuclear emulsions (1970) (1)
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs). (1988) (1)
CDK4 is an essential insulin effector in adipocytes (2022) (1)
Interplay between genes and environment in insulin resistance and metabolic syndrome: the unique role of the gut microbiome (2015) (1)
Clinical assessment, biological responses, and comparison to the IGF-F receptor (1988) (1)
Molecular Aspects of Insulin Signaling (2011) (1)
Insulin allergy and insulin resistance. (1994) (1)
HORMONAL REGULATION OF Na+-DEPENDENT TRANSPORT IN HEPATOCYTES AND HEPATOMA CELLS1 (1982) (1)
1178-P: Portal Vein Metabolites as Intermediate Regulators of the Gut Microbiome in Insulin Resistance (2021) (1)
Application of the strong-absorption model to antiproton nuclear scattering at 3 GeV/c in ionographic emulsions (1967) (1)
FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism (2018) (1)
Mono clonal antibodies as probes for allergenic and antigenic determinants on the rye i allergen (1982) (1)
Roles of Insulin Receptors in Endothelial Cells in Metabolism and Proliferative Retinopathy (2002) (1)
Genetic Control of the Immune Response to Insulin in Man and Experimental Animals (1984) (1)
Acromegaly and Cardiovascular Disorders (2020) (1)
Multichordal charge exchange recombination spectroscopy on Doublet III (1985) (1)
An introduction to type II diabetes: commentary (1995) (1)
Study of thep¯d→psp¯nπ+π−Reaction at 5.55 GeV/c (1972) (1)
Roles of vascular endothelial and smooth muscle cells in the vasculoprotective effect of insulin in a mouse model of restenosis (2021) (1)
1725-P: Viral Insulins as Agonists and Antagonists on Insulin/IGF-1 Receptors (2020) (1)
35-OR: Physiological Insulin Regulates Alternative mRNA Splicing in Liver and Muscle at Multiple Levels (2019) (1)
The Role of Covalent and Non-Covalent Mechanisms in Insulin Receptor Action (1990) (0)
Modeling the Spectrum of Human Insulin Resistance Using Induced Pluripotent Stem Cells (2018) (0)
Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin (2020) (0)
Mild cold environment stimulates myocardial glucose uptake in healthy adults (2011) (0)
Increased Adipose Tissue Mitochondrial Oxidation Protects Mice against Obesity and Insulin resistance. (2012) (0)
ANIMAL MODELS OF IRS-1/IRS-2 KNOCKOUTS (2002) (0)
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation. (2023) (0)
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD. (2023) (0)
291-OR: Exercise Modulates Glucose Metabolism in Part through Changes in the Gut Microbiome (2019) (0)
Modulation of the Gut Microbiome by Novel Synthetic Glycans for the Production of Propionate and the Reduction of Cardiometabolic Risk Factors (2022) (0)
SESSION 1: “Molecular Mechanisms and Therapeutic Approaches to Insulin Resistance” (1990) (0)
Insulin Resistance and Gender Define a Cell Autonomous Supernetworkof Protein Phosphorylation (2021) (0)
MicroRNA sequence codes for small extracellular vesicle release and cellular retention (2021) (0)
Radio continuum emission from T Tauri stars and associated structures (1986) (0)
PROTEIN TYROSINE PHOSPHATASE 1 B ( PTP 1 B ) DEFICIENCY REDUCES INSULIN RESISTANCE AND THE DIABETIC PHENOTYPE IN MICE WITH POLYGENIC INSULIN RESISTANCE (2007) (0)
Rad GTPase Deficiency Leads to Cardiac Hypertrophy Molecular Cardiology (2007) (0)
Insulin Acutely Regulates Gene Expression in Brain–A New Potential Major Level of Control of Metabolism and Neurotransmission (2018) (0)
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism (2019) (0)
Differentiation Substrates in Brown Adipocyte Differential Roles of Insulin Receptor (2004) (0)
PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION (1999) (0)
223-OR: ADA Presidents' Select Abstract: Novel Ligand and Kinase-Independent Signaling by the Insulin Receptor (2022) (0)
The Origin of Fat: Can We Nip Obesity in the Vascular Bud? (2015) (0)
The insulin receptor goes nuclear (2019) (0)
Dissection of Insulin-Dependent Pathways in Skeletal Muscle under Physiological and Diabetic Conditions (2018) (0)
Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity (2020) (0)
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis (2023) (0)
expression in rat skeletal muscles Muscle contractile activity regulates Sirt3 protein (2015) (0)
Therapeutic Insulin Components EVIDENCE FOR GENETIC CONTROL BY THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX (1983) (0)
FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism (2019) (0)
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis (2020) (0)
Obese IRS-1(±) mice as a model for type 2 diabetes (2000) (0)
Autoimmunity and the aetiology of insulin-dependent diabetes mellitus (1982) (0)
PSUN312 Interaction Between Insulin Sensitivity Status and Cex in control of Gene Expression in Human iPS Cell-Derived Myoblasts (2022) (0)
187-OR: Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones (2019) (0)
Structure, phosphorylation and desensitization of the insulin receptor in hepatoma cells. (1985) (0)
The p85 (cid:2) Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance (cid:1) † (2007) (0)
Evaluation of the Unfolded Protein Response: PI 3-Kinase Regulatory Subunits as Regulators of the IRE1α Pathway (2015) (0)
CDK4 is an essential insulin effector in adipocytes (2023) (0)
FIGURE 9 - mRNA Expression for Genes Regulating ROS Production Is Altered in Patient Cells (2009) (0)
Familial Exposure Antibiotics & Other drugs Other Birth / Perinatal Colonization Diet and Food Quality Host Susceptibility (2016) (0)
Depot-specific differences in adipocyte biology and adipose tissue gene expression – parallel regulation in humans and mice (2005) (0)
1785-P: Mice with Muscle-Specific Insulin Receptor Overexpression Are Protected from Diet-Induced Obesity and Glucose Intolerance but Develop Post-Receptor Insulin Resistance (2019) (0)
1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission (2019) (0)
Serum Exosomal Proteins—A New Component of Intercellular Communication in Metabolism (2018) (0)
334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level (2021) (0)
, Amelia Cardiac Development and Function Growth Factor 1 Receptor Signaling in Essential Role of Insulin and Insulin-Like (2007) (0)
Molecular biology of diabetes. I. Autoimmunity and genetics; Insulin synthesis and secretion Edited by Boris Draznin and Derek LeRoith. Totowa, NJ, Humana Press, 1994, $89.50 (xiii + 404 pages), ISBN 0-896-03286-8 (1995) (0)
FoxK1 and FoxK2 are positive regulators for IR and IGF1R signalling in cell proliferation and metabolism (2019) (0)
Receptors for Peptide Hormones (2020) (0)
Study of the reaction $\overline{p}d \rightarrow p_s \pi^+ 2\pi^- \pi^0$ at 5.5 GeV/c incident momentum (1971) (0)
Rod Photoreceptor Cells Mice Lacking Insulin Receptor Gene in Loss of Neuroprotective Survival Signal in Mechanisms of Signal Transduction : (2008) (0)
ANTIBODIES TO INSULIN RECEPTORS: PROBES OF RECEPTOR STRUCTURE AND FUNCTION (1978) (0)
Causes and implications of the loss of small-scale surface texture in Viking Orbiter images (1985) (0)
Insulin and the cell membrane : proceedings of the International Symposium on Insulin and the Cell Membrane, Smolenice Castle, Czechoslovakia, 27-30 June 1988 (1990) (0)
Matter density models and antiproton-(emulsion) nuclei elastic scattering at 3 GeV/c (1972) (0)
PKC d regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans (2019) (0)
Study of the reaction ¯pd→ps π+2π−π0 at 5.5 GeV/c incident momentum (1971) (0)
Rare Earth Spin Dynamics in the Nd-Doped High-Tc Superconductor La2−xSrxCuO4 (2002) (0)
OBSERVATION OF THE d* EFFECT IN THE anti pd $Yields$ p anti p $pi$$sup +$ $pi$$sup -$n REACTION AT 5.55 GeV/c. (1971) (0)
Insulin signaling failures in the brain linked to Alzheimer's disease (2020) (0)
The effects of insulin on cloudman s91 melanoma cells. Abstr. (1980) (0)
P-124: Novel interactions of IRS-1 in human skeletal muscle (2009) (0)
Antibodies to the Insulin Receptor as Tools in the Study of Receptor Structure and Function (1987) (0)
Eph Receptor Signaling and Ephrins (2013) (0)
A study of HLA alloantigen frequencies in insulin allergic and non-allergic diabetics (1981) (0)
A genetic analysis of insulin and diabetes regulated gene expression (2005) (0)
Lymphocyte proliferation response to bovine and porcine insulin suggest MHC-linked immune response gene in man (1982) (0)
Antibodies to Insulin and Insulin Receptors: Mechanisms of Insulin Resistance (1984) (0)
Reduced (cid:1) -cell mass and altered glucose sensing impair insulin-secretory function in (cid:1) IRKO mice (2003) (0)
[Antibodies directed against the insulin receptor and insulin-resistant diabetes]. (1980) (0)
C. Ronald Kahn, MD, of Joslin Diabetes Center and Harvard Medical School Wins Bristol-Myers Squibb Metabolic Research Award (2004) (0)
Membrane receptors and cellular regulation : a UCLA symposium held in Park City, Utah, March 25-30, 1984 (1985) (0)
Sharing of biological effect and rec insulin and platelet-derived growth (hystricomorphs/human fibroblasts) (2016) (0)
IMPAIRED HEPATIC REGENERATION IN LIVER‐SPECIFIC INSULIN RECEPTOR KNOCKOUT MICE.: Abstract# 334 Poster Board #‐Session: P181‐I (2000) (0)
Differential regulation of insulin signaling by amino acids (2009) (0)
An open letter to the American Diabetes Association board of directors (2017) (0)
Metabolic Effects of Vanadyl Sulfate in Humans With N o n - I n s u l i n - D e p e n d e n t Diabetes Mellitus: In Vivo and In Vitro Studies (2000) (0)
L'insulinorésistance musculaire génétique chez la souris MIRKO entraîne une altération acquise de l'action hépatique de l'insuline : implications dans la physiopathologie du diabète de type 2 (2008) (0)
Congenital hypothyroidism in growth hormone, thyrotropin, deficiencies a young man with and prolactin (1976) (0)
Impairment Of The Retinal Insulin Receptor: Implications For Retinal Neurodegenerations (2006) (0)
CR Kahn High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-Specific Insulin Receptor Knockout ( LIRKO ) Mice (2007) (0)
Macromolecular Lactic Acid Dehydrogenase (2020) (0)
207-OR: Liver-Preadipocyte Cross Talk Reverses Lipodystrophy-Induced Insulin Resistance (2020) (0)
Partial dependence on IRS-1 for normal and IGF-I induced small bowel growth in vivo (2000) (0)
Diabetes and the endocrine pancreas: Editorial overview (1994) (0)
Structure-function relations of the thyrotropin receptor - discussion (1982) (0)
Foot and Ankle Trauma (1991) (0)
Letter to the Editor (1974) (0)
Roles of Amylin in Diabetes and in Regulation of Nutrient Load (1998) (0)
Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin (1980) (0)
How insulin works - Shedding some light into the black box (1989) (0)
Issues and Updates (1993) (0)
An Association Between NIDDM and a GAA Trinucleotide Repeat Polymorphism in the X 2 5/ F r a t a x i n ( F r i e d r e i c h 's Ataxia) Gene (1998) (0)
1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome (2020) (0)
1733-P: Phosphoproteomic Analysis of Insulin Action Using Human IPS-Derived Myoblasts Reveals Important Interactions between Differences Based on Insulin Sensitivity and Sex (2020) (0)
Rapid internalization of the insulin receptor in rat hepatoma cells (1987) (0)
Citation for the 2000 Roy O. Greep Award Lecture of The Endocrine Society to Dr. Christin Carter-Su. (2000) (0)
Function of the Insulin Receptor Kinase in the Intact Cell (2018) (0)
Viral hormones: Expanding dimensions in endocrinology (2020) (0)
Citation for the 2000 Roy O. Greep Award Lecture of The Endocrine Society to Dr. Christin Carter-Su. (2000) (0)
[Insulin signalization and molecular mechanisms of insulin resistance]. (1999) (0)
Supplemental Information Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Speci fi c Deletion of the Insulin Receptor (0)
Increased insulin sensitivity i subunit of phosphoinositide (2016) (0)
Mitochondria , obesity and aging (2013) (0)
People to know 2014. (2014) (0)
Correction to: Defining the underlying defect in insulin action in type 2 diabetes (2022) (0)
Thymic Lymphocytes in Obese ( ob / ob ) Mice (2002) (0)
Letter: Hypercalcemia and streptozotocin. In comment. (1974) (0)
Methods for the study of structure and function (1988) (0)
Tolbert, E. L. (1974). Counselling for Career Development. (1974) (0)
O-13: Functional role of synaptobrevins in insulinstimulated translocation of GLUT4 glucose transporters (2009) (0)
CONTRACTION-INDUCED GLUCOSE TRANSPORT AND GLYCOGEN DEPLETION IN MUSCLES FROM MICE HETEROZYGOUS FOR IRS-1 PROTEIN (1998) (0)
Effect of phospholipase treatment on insulin receptor signal transduction (1992) (0)
Insulin signalization and molecular mechanisms of insulin resistance (1999) (0)
298-OR: Disruption of Multiple Cell-Autonomous Protein Phosphorylation Networks Underlies Muscle Insulin Resistance in Type 2 Diabetes (2020) (0)

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