Charles T. Esmon

Q: What Schools Are Affiliated With Charles T. Esmon

Charles T. Esmon is affiliated with the following schools: University of Amsterdam, University of Minnesota, University of Oklahoma Health Sciences Center, University of Navarra, University of Oklahoma, University of California, San Francisco, Maastricht University, University of Utah

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Charles T. Esmon

Philosophy

#2393

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#4105

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#558

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#1013

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Charles T. Esmon

Biology

#2727

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#4296

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Molecular Biology

#170

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#174

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Biochemistry

#231

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#289

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Philosophy
Biology

Charles T. Esmon's Degrees

PhD Biochemistry University of Oklahoma Health Sciences Center
Doctorate Medicine University of Oklahoma Health Sciences Center

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Charles T. Esmon's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Extracellular histones are major mediators of death in sepsis (2009) (1284)
The roles of protein C and thrombomodulin in the regulation of blood coagulation. (1984) (1028)
The interactions between inflammation and coagulation (2005) (858)
Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. (1981) (815)
The regulation of natural anticoagulant pathways (1987) (682)
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. (2011) (682)
Dysfunction of endothelial protein C activation in severe meningococcal sepsis. (2001) (661)
Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. (1982) (647)
Familial protein S deficiency is associated with recurrent thrombosis. (1984) (635)
Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. (1989) (621)
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. (1994) (536)
Recurrent venous thromboembolism in patients with a partial deficiency of protein S. (1984) (527)
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. (1996) (522)
Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. (2003) (504)
Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. (1987) (497)
The protein C pathway. (2003) (494)
The protein C pathway (2000) (489)
Inflammation and thrombosis (2003) (432)
Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury (2011) (424)
Thrombomodulin mutations in atypical hemolytic-uremic syndrome. (2009) (420)
Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. (1982) (404)
The inhibition of blood coagulation by activated Protein C through the selective inactivation of activated Factor V. (1979) (399)
Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface (1995) (394)
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. (2017) (390)
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis (2007) (371)
Structure of the antithrombin–thrombin–heparin ternary complex reveals the antithrombotic mechanism of heparin (2004) (366)
Basic mechanisms and pathogenesis of venous thrombosis. (2009) (358)
Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. (1989) (339)
Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex. (1990) (337)
Endogenous Histones Function as Alarmins in Sterile Inflammatory Liver Injury Through Toll-like Receptor 9 in Mice (2011) (331)
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin‐dependent protein C activation (2011) (322)
An abnormal plasma distribution of protein S occurs in functional protein S deficiency. (1986) (318)
Functional and immunologic protein S levels are decreased during pregnancy (1986) (309)
Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. (1997) (309)
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. (2000) (303)
Generation of fibrinolytic activity by infusion of activated protein C into dogs. (1981) (303)
The protein C anticoagulant pathway. (1992) (300)
Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. (1981) (298)
The impact of the inflammatory response on coagulation. (2004) (296)
Regulation of blood coagulation. (2000) (290)
Endothelial cell protein C receptor plays an important role in protein C activation in vivo. (2001) (289)
Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis (2002) (286)
Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. (2006) (284)
Inflammation, sepsis, and coagulation. (1999) (282)
Role of Coagulation Inhibitors in Inflammation (2001) (277)
Inflammation and Coagulation: Linked Processes Potentially Regulated Through a Common Pathway Mediated by Protein C (1991) (271)
The Endothelial Cell Protein C Receptor (2000) (266)
The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity. (1979) (266)
Critical Role of Activated Protein C in Early Coagulopathy and Later Organ Failure, Infection and Death in Trauma Patients (2012) (260)
The conversion of prothrombin to thrombin. I. Characterization of the reaction products formed during the activation of bovine prothrombin. (1974) (256)
Crosstalk between inflammation and thrombosis. (2004) (246)
Inflammation and the activated protein C anticoagulant pathway. (2006) (245)
A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation* (2013) (244)
Molecular Events that Control the Protein C Anticoagulant Pathway (1993) (232)
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. (1991) (230)
Protein-C: biochemistry, physiology, and clinical implications. (1983) (225)
DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. (1991) (219)
A new carboxylation reaction. The vitamin K-dependent incorporation of H-14-CO3- into prothrombin. (1975) (217)
Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation. (1988) (217)
Innate immunity and coagulation (2011) (210)
The 2.8 A crystal structure of Gla‐domainless activated protein C. (1996) (209)
Thrombomodulin blocks the ability of thrombin to activate platelets. (1983) (204)
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism (2002) (199)
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. (2013) (197)
Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation (2001) (195)
Metalloproteolytic Release of Endothelial Cell Protein C Receptor* (2000) (194)
The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid* (2002) (194)
Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. (1993) (190)
Endothelial Protein C Receptor (1999) (183)
PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin* (2005) (182)
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury (2013) (182)
Inflammation, innate immunity and blood coagulation (2010) (182)
Interactions between the innate immune and blood coagulation systems (2004) (180)
Identification of functional endothelial protein C receptor in human plasma. (1997) (179)
Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function* (2000) (179)
Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial. (2019) (177)
Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states. (1986) (176)
Oral contraceptives and gender affect protein S status. (1987) (171)
Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase. (1986) (171)
Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin Complex (*) (1995) (171)
Why do animal models (sometimes) fail to mimic human sepsis? (2004) (167)
Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C. (1994) (166)
Patients with severe sepsis vary markedly in their ability to generate activated protein C. (2004) (159)
INCREASE IN ACTIVATED PROTEIN C MEDIATES ACUTE TRAUMATIC COAGULOPATHY IN MICE (2009) (159)
Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C. (1983) (154)
Endothelial cell protein C receptor: a multiliganded and multifunctional receptor. (2014) (153)
Infection of vascular endothelial cells with herpes simplex virus enhances tissue factor activity and reduces thrombomodulin expression. (1990) (152)
Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. (2001) (150)
Disruption of the Endothelial Cell Protein C Receptor Gene in Mice Causes Placental Thrombosis and Early Embryonic Lethality* (2002) (149)
Endothelial Cell Protein C Receptor Acts as a Cellular Receptor for Factor VIIa on Endothelium* (2007) (148)
C4b-binding protein exacerbates the host response to Escherichia coli. (1991) (146)
Determination of functional levels of protein C, an antithrombotic protein, using thrombin-thrombomodulin complex. (1984) (143)
On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies. (1995) (140)
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin (2005) (140)
Cell mediated events that control blood coagulation and vascular injury. (1993) (140)
The Endothelial Cell Protein C Receptor (1996) (139)
Protein C anticoagulant system—anti-inflammatory effects (2011) (138)
Protein S deficiency occurs in the nephrotic syndrome. (1987) (136)
The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody. (1988) (134)
Coagulation and inflammation (2001) (133)
Vitamin K-dependent carboxylase. Requirements of the rat liver microsomal enzyme system. (1976) (132)
New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins (2002) (131)
Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin? (2000) (131)
The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. (1987) (131)
The Soluble Endothelial Protein C Receptor Binds to Activated Neutrophils: Involvement of Proteinase-3 and CD11b/CD181 (2000) (130)
The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation. (1991) (130)
Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. (2000) (128)
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc (2012) (123)
Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner (2013) (121)
Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. (1991) (121)
The functional significance of vitamin K action. Difference in phospholipid binding between normal and abnormal prothrombin. (1975) (121)
Activation of protein C in vivo. (1982) (118)
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. (2012) (116)
An update on clinical and basic aspects of the protein C anticoagulant pathway. (1995) (115)
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells (2015) (115)
Protein S is required for bovine platelets to support activated protein C binding and activity. (1985) (115)
The Protein C Pathway: New Insights (1997) (113)
Extracellular histone release in response to traumatic injury: Implications for a compensatory role of activated protein C (2012) (112)
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor‐α converting enzyme/ADAM17 (2007) (112)
Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis. (1994) (112)
Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. (2004) (111)
Loss of prothrombin and of factor Xa-factor Va interactions upon inactivation of factor Va by activated protein C. (1984) (109)
Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition. (2017) (109)
A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase. (1976) (107)
Extraembryonic expression of EPCR is essential for embryonic viability. (2005) (106)
The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives. (1992) (106)
The conversion of prothrombin to thrombin. IV. The function of the fragment 2 region during activation in the presence of factor V. (1974) (105)
Targeting factor Xa and thrombin: impact on coagulation and beyond (2013) (105)
Protein S Alters the Active Site Location of Activated Protein C above the Membrane Surface (1997) (104)
A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation (2003) (104)
Involvement of Thrombin Anion-binding Exosites 1 and 2 in the Activation of Factor V and Factor VIII* (1996) (103)
A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site. (1988) (102)
Structure and functions of the endothelial cell protein C receptor. (2004) (101)
Regulation and functions of the protein C anticoagulant pathway. (1999) (101)
Protein C activation. (1984) (99)
Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa. (1989) (97)
The link between vascular features and thrombosis. (2011) (97)
The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity. (1992) (96)
Valves of the deep venous system: an overlooked risk factor. (2007) (94)
Inflammatory and Procoagulant Mediator Interactions in an Experimental Baboon Model of Venous Thrombosis (1993) (93)
Antiphospholipid antibodies and the protein C pathway. (2000) (93)
A plausible mechanism for prothrombin activation by factor Xa, factor Va, phospholipid, and calcium ions. (1974) (93)
The Ser219–>Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype (2006) (92)
A polypeptide region of bovine prothrombin specific for binding to phospholipids. (1973) (92)
Does Inflammation Contribute to Thrombotic Events? (2000) (92)
Reconstitution of the Human Endothelial Cell Protein C Receptor with Thrombomodulin in Phosphatidylcholine Vesicles Enhances Protein C Activation* (1999) (92)
Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. (2011) (91)
The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors* (2010) (91)
Venous thrombosis in the elderly: more questions than answers. (2007) (88)
Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid. (1983) (87)
Expression and purification of a soluble tissue factor fusion protein with an epitope for an unusual calcium-dependent antibody. (1992) (87)
The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway. (2000) (86)
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. (2009) (85)
The thrombin E192Q–BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin (1997) (85)
The Interaction between the Endothelial Cell Protein C Receptor and Protein C Is Dictated by the γ-Carboxyglutamic Acid Domain of Protein C* (1997) (84)
Activated protein C inhibits platelet prothrombin-converting activity. (1979) (83)
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101. (1994) (82)
Early Loss of Thrombomodulin Expression Impairs Vein Graft Thromboresistance: Implications for Vein Graft Failure (2002) (81)
Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C Receptor (2001) (80)
The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form. (2003) (78)
Molecular circuits in thrombosis and inflammation (2013) (78)
Proteolytic formation and properties of functional domains of thrombomodulin. (1987) (77)
Thrombin Glu-39 restricts the P'3 specificity to nonacidic residues. (1991) (77)
Activated protein C protects against myocardial ischemia/ reperfusion injury via inhibition of apoptosis and inflammation. (2009) (76)
On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity. (1986) (75)
Role of free protein S and C4b binding protein in regulating the coagulant response to Escherichia coli. (1995) (74)
Inhibition of activated protein C anticoagulant activity by prothrombin. (1999) (74)
The conversion of prothrombin to thrombin. II. Differentiation between thrombin- and factor Xa-catalyzed proteolyses. (1974) (74)
Distribution of the thrombomodulin antigen in the rabbit vasculature. (1986) (72)
The discovery of thrombomodulin (2004) (72)
Protein C pathway in sepsis (2002) (72)
The complete cDNA sequence of bovine coagulation factor V. (1992) (71)
Reprint of Crosstalk between inflammation and thrombosis (2008) (70)
Role of activated protein C and its receptor in inhibition of tumor metastasis. (2009) (70)
Vitamin K-dependent carboxylase. Solubilization and properties. (1976) (70)
Crosstalk between inflammation and thrombosis. (2008) (70)
The action of thrombin on blood clotting factor V: conversion of factor V to a prothrombin-binding protein. (1973) (70)
The endothelial protein C receptor (2006) (70)
Microthrombomodulin. Residues 310-486 from the epidermal growth factor precursor homology domain of thrombomodulin will accelerate protein C activation. (1989) (70)
Venous and arterial thrombosis – pathogenesis and the rationale for anticoagulation (2011) (70)
Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction: analysis by analytical ultracentrifugation. (1989) (69)
Molecular Cloning and Expression of Murine and Bovine Endothelial Cell Protein C/Activated Protein C Receptor (EPCR) (1995) (68)
A comparative study of the protein C pathway in septic and nonseptic patients with organ failure. (2007) (68)
Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C (2012) (67)
Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence. (2005) (67)
Protein C Activation Following Coronary Artery Occlusion in the In Situ Porcine Heart (1991) (67)
Reconstitution of rabbit thrombomodulin into phospholipid vesicles. (1987) (67)
The postimplantation embryo differentially regulates endometrial gene expression and decidualization. (2007) (66)
Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. (1998) (65)
A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function (2001) (65)
The conversion of prothrombin to thrombin. III. The factor Xa-catalyzed activation of prothrombin. (1974) (65)
The effect of membrane composition on the hemostatic balance. (1999) (64)
The Role of Extracellular Histones in Influenza Virus Pathogenesis. (2018) (64)
Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells (2014) (64)
The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness (2001) (64)
Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination. (2015) (62)
Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid. (1984) (61)
New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. (1997) (61)
Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development (2013) (60)
The Endothelial Cell Protein C Receptor (1996) (59)
The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors. (1993) (59)
Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-Å structure of the heparin-bridged complex (2008) (58)
Do-all receptor takes on coagulation, inflammation (2005) (57)
Protein C replacement in severe meningococcemia: rationale and clinical experience. (2001) (56)
Distribution of Endothelial Cell Protein C/Activated Protein C Receptor (EPCR) During Mouse Embryo Development (2002) (56)
Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin. (1992) (56)
Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. (2010) (56)
Protein C and acute inflammation: a clinical and biological perspective. (2013) (55)
Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. (2008) (55)
Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma. (2008) (55)
Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. (2012) (55)
Analysis of the functions of the first epidermal growth factor-like domain of factor X. (1993) (55)
Mutation of Glu-80-->Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex. (1994) (55)
Purification of an apparent rat liver prothrombin precursor: characterization and comparison to normal rat prothrombin. (1975) (54)
Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride‐induced septic shock (2009) (53)
Cellular regulation of the protein C pathway. (1995) (53)
Coagulation inhibitors in inflammation. (2005) (53)
The conversion of prothrombin to thrombin. V. The activation of prothrombin by factor Xa in the presence of phospholipid. (1974) (53)
A Chimeric Protein C Containing the Prothrombin Gla Domain Exhibits Increased Anticoagulant Activity and Altered Phospholipid Specificity* (1998) (52)
The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin. (1993) (51)
Structure of bovine blood coagulation factor Va. Determination of the subunit associations, molecular weights, and asymmetries by analytical ultracentrifugation. (1984) (51)
Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom). (1980) (50)
Relocating the Active Site of Activated Protein C Eliminates the Need for Its Protein S Cofactor (1999) (50)
Non‐hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia (2007) (50)
7E3 F(ab')2, a monoclonal antibody to the platelet GPIIb/IIIa receptor, protects against microangiopathic hemolytic anemia and microvascular thrombotic renal failure in baboons treated with C4b binding protein and a sublethal infusion of Escherichia coli. (1997) (49)
Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S. (2011) (49)
The effects of phospholipid and factor Va on the inhibition of factor Xa by antithrombin III. (1979) (49)
Formation of a calcium-binding site on bovine activated factor V following recombination of the isolated subunits. (1982) (48)
Roles of Inflammation and the Activated Protein C Pathway in the Brain Edema Associated With Cerebral Venous Sinus Thrombosis (2010) (47)
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. (2019) (46)
Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. (1993) (46)
Lipid presentation by the protein C receptor links coagulation with autoimmunity (2021) (45)
Activated protein C protects against ventilator-induced pulmonary capillary leak. (2009) (44)
"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. (1992) (44)
Thrombogenic Mechanisms of Antiphospholipid Antibodies (1997) (43)
Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy. (1994) (43)
Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor (2015) (42)
Anticoagulation proteins C and S. (1987) (42)
Asp-70-->Lys mutant of factor X lacks high affinity Ca2+ binding site yet retains function. (1994) (42)
Comparison of coagulation factor Xa and des-(1-44)factor Xa in the assembly of prothrombinase. (1984) (41)
Endothelial Cells and Extracellular Calmodulin Inhibit Monocyte Tumor Necrosis Factor Release and Augment Neutrophil Elastase Release* (1997) (41)
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions (2015) (41)
Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity. (1997) (40)
Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor (2013) (40)
The active site of membrane-bound meizothrombin. A fluorescence determination of its distance from the phospholipid surface and its conformational sensitivity to calcium and factor Va. (1990) (40)
The active site of the thrombin-thrombomodulin complex. A fluorescence energy transfer measurement of its distance above the membrane surface. (1989) (40)
Inhibition of APC anticoagulant activity on oxidized phospholipid by anti-{beta}2-glycoprotein I monoclonal antibodies. (2005) (39)
Occupancy of anion binding exosite 2 on thrombin determines Ca2+ dependence of protein C activation. (1994) (39)
Roles of Coagulation and Fibrinolysis in Angiotensin II‐Enhanced Microvascular Thrombosis (2014) (39)
Switching serine protease specificity (1998) (36)
Is APC activation of endothelial cell PAR1 important in severe sepsis?: No (2005) (36)
Localization of Phosphatidylserine Binding Sites to Structural Domains of Factor Xa * (2002) (35)
Infusion of Phospholipid Vesicles Amplifies the Local Thrombotic Response to TNF and Anti-Protein C into a Consumptive Response (1996) (35)
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. (2011) (34)
Modeling zymogen protein C. (2000) (34)
Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo (2014) (34)
Proteolytic formation of either of the two prothrombin activation intermediates results in formation of a hirugen-binding site. (1991) (33)
Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis. (1999) (33)
Evidence for multiple conformational changes in the active center of thrombin induced by complex formation with thrombomodulin: an analysis employing nitroxide spin-labels. (1988) (33)
Protein S and protein C Biochemistry, physiology, and clinical manifestation of deficiencies. (1992) (32)
Localization of thrombomodulin antigen in rabbit endothelial cells in culture. An immunofluorescence and immunoelectron microscope study. (1986) (32)
Thrombomodulin increases the rate of thrombin inhibition by BPTI. (1998) (32)
Lipid Oxidation Enhances the Function of Activated Protein C* (2001) (32)
Effects of thrombomodulin and coagulation Factor Va-light chain on protein C activation in vitro. (1984) (32)
Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor. (1994) (32)
Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa (2012) (31)
Interactions between heparin and factor Xa. Inhibition of prothrombin activation. (1979) (31)
Inhibition of Endogenous Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis by Inducing Myeloid-Derived Suppressor Cells (2013) (30)
An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation (2017) (29)
Protein C and the endothelium. (1988) (29)
Contribution of Residue 192 in Factor Xa to Enzyme Specificity and Function (*) (1995) (29)
Protein C activation. (1993) (29)
Antibodies to thrombomodulin are found in patients with lupus anticoagulant and unexplained thrombosis. (2000) (28)
Molecular basis of residue 192 participation in determination of coagulation protease specificity. (1996) (28)
Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1. (2018) (28)
The role of calcium ions in factor X activation by thrombin E192Q. (1992) (28)
Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease. (2014) (28)
Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. (2007) (27)
The effect of prothrombin fragment 2 on the inhibition of thrombin by antithrombin III. (1979) (27)
Evidence for the important role of inflammation in xenotransplantation (2019) (27)
Characterization and Regulation of the 5′-Flanking Region of the Murine Endothelial Protein C Receptor Gene* (2000) (27)
sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. (2012) (27)
Structural and functional studies of γ-carboxyglutamic acid domains of factor VIIa and activated Protein C: role of magnesium at physiological calcium. (2013) (27)
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. (2017) (26)
Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems (2012) (26)
Tryptophans 231 and 234 in protein C report the Ca(2+)-dependent conformational change required for activation by the thrombin-thrombomodulin complex. (1995) (26)
A domain of membrane-bound blood coagulation factor Va is located far from the phospholipid surface. A fluorescence energy transfer measurement. (1986) (26)
The high affinity calcium-binding site involved in protein C activation is outside the first epidermal growth factor homology domain. (1992) (25)
Concordant expression of tissue factor and class II MHC antigens in human placental endothelium. (1990) (25)
Interaction of blood coagulation factor Va with phospholipid vesicles examined by using lipophilic photoreagents. (1987) (25)
The factor V activating enzyme of Russell's viper venom (1973) (25)
ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. (2017) (25)
Ca2+ dependence of the interactions between protein C, thrombin, and the elastase fragment of thrombomodulin. Analysis by ultracentrifugation. (1992) (24)
Initiation of the Protein C Pathway (1991) (24)
Role of the protein C pathway in the extraintestinal thrombosis associated with murine colitis. (2008) (24)
Regulation of long‐term repopulating hematopoietic stem cells by EPCR/PAR1 signaling (2016) (24)
Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect (2015) (23)
Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes (2018) (23)
Phosphatidylethanolamine at the endothelial surface of aortic flow dividers (2009) (23)
Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis. (2015) (22)
Expression of endothelial protein C receptor in cortical peritubular capillaries associates with a poor clinical response in lupus nephritis. (2008) (22)
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis. (2020) (22)
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury (2008) (22)
Lupus anticoagulants and thrombosis: the role of phospholipids. (1997) (22)
Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa (2013) (21)
Protein S enhances C4b binding protein interaction with neutrophils. (1993) (20)
Role of Coagulation Factors in Cerebral Venous Sinus and Cerebral Microvascular Thrombosis (2010) (20)
Fondaparinux pentasaccharide reduces sepsis coagulopathy and promotes survival in the baboon model of Escherichia coli sepsis (2020) (20)
Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. (2001) (20)
Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia‐reperfusion injury (2017) (20)
Endogenous protein C has a protective role during Gram‐negative pneumosepsis (melioidosis) (2013) (20)
The natural anticoagulant protein S is decreased in male smokers. (1991) (19)
The Interaction of a Ca 2 +-dependent Monoclonal Antibody with the Protein C Activation Peptide Region (2001) (19)
Interaction of Thrombin with Thrombomodulin (1986) (19)
Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation. (2011) (19)
Extracellular histones zap platelets. (2011) (19)
Design of constructs for the expression of biologically active recombinant human factors X and Xa. Kinetic analysis of the expressed proteins. (1991) (18)
Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis) (2013) (18)
Thrombosis in Pediatric Cardiology and Congenital Heart Disease Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on Challenges and Priorities for Research: A Report From the National Heart, Lung, and (2014) (17)
The effect of aggregation and release on platelet prothrombin-converting activity. (1979) (17)
Clinical expert round table discussion (session 3) at the Margaux Conference on Critical Illness: the role of activated protein C in severe sepsis. (2001) (17)
New Potential Therapeutic Modalities: aPC (1999) (16)
Factor VIIa interaction with EPCR modulates the hemostatic effect of rFVIIa in hemophilia therapy: Mode of its action. (2017) (16)
Treatment with Activated Protein C (aPC) Is Protective during the Development of Myocardial Fibrosis: An Angiotensin II Infusion Model in Mice (2012) (16)
Proline at the P2 position in protein C is important for calcium-mediated regulation of protein C activation and secretion. (1994) (15)
Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C. (1999) (15)
Isolation of an abnormal protein C molecule from the plasma of a patient with thrombotic diathesis. (1988) (15)
PAR 1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells (2016) (15)
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently. (2020) (15)
Inflammation and thrombosis: the impact of inflammation on the protein C anticoagulant pathway. (1995) (15)
Platelet Endothelial Cell Adhesion Molecule Targeted Oxidant-Resistant Mutant Thrombomodulin Fusion Protein with Enhanced Potency In Vitro and In Vivo (2013) (15)
Impact of endogenous protein C on pulmonary coagulation and injury during lethal H1N1 influenza in mice. (2011) (15)
The C-terminal fragment of axon guidance molecule Slit3 binds heparin and neutralizes heparin's anticoagulant activity. (2012) (14)
Lupus anticoagulants, thrombosis and the protein C system. (1999) (14)
The molecular mechanisms of heparin action III. The anticoagulant properties of polyanetholesulfonate. (1978) (14)
The discovery of the endothelial cell protein C receptor (2010) (14)
Inflammation: They're not just for clots anymore (1995) (13)
Ca2+-dependent structural changes in bovine blood coagulation factor Va and its subunits. (1989) (13)
The APCs of neuroprotection. (2009) (13)
Inflammation: the protein C pathway (1997) (12)
Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: translation from in vitro to in vivo. (2012) (12)
Endogenous protein C inhibits activation of coagulation and transiently lowers bacterial outgrowth in murine Escherichia coli peritonitis (2011) (12)
Activation of Protein C by a Complex between Thrombin and Endothelial Cell Surface Protein (1982) (12)
The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis. (2015) (12)
The molecular mechanisms of heparin action: II. Separation of functionally different heparins by affinity chromatography. (1979) (12)
Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis. (1994) (11)
What did we learn from new oral anticoagulant treatment? (2012) (11)
Molecular mechanisms of thrombosis in meningococcal septicaemia: the role of the protein C pathway in vivo (2001) (11)
Factor Xa-factor Va complex assembles in two dimensions with unexpectedly high affinity: an experimental and theoretical approach. (1995) (11)
Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. (2016) (11)
Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties (2016) (10)
Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. (2011) (10)
Far from the Heart: Counteracting coagulation (2010) (10)
Targeted Inhibition of Activated Protein C Anticoagulant Activity By Monoclonal Antibody HAPC1573 for Treatment of Hemophilia (2016) (10)
Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy. (2020) (10)
Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment. (2014) (10)
The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis (2013) (9)
Inhibition of a thrombin anion-binding exosite-2 mutant by the glycosaminoglycan-dependent serpins protein C inhibitor and heparin cofactor II. (2002) (9)
Limited Ability to Activate Protein C Confers Left Atrial Endocardium A Thrombogenic Phenotype: A Role in Cardioembolic Stroke? (2011) (9)
Postribosomal function of vitamin K in prothrombin synthesis. (1974) (9)
The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis (2014) (9)
Protein C, isolation and potential use in prevention of thrombosis. (1987) (9)
EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice. (2020) (9)
Neutrophil Extracellular Traps Drive Bleomycin‐Induced Lung Fibrosis by Regulating TGFβ1‐Dependent Interactions of Platelets and Macrophages (2016) (8)
Factor VIIa induces extracellular vesicles from the endothelium: A potential mechanism for its hemostatic effect. (2021) (8)
Group V secretory phospholipase A2 impairs endothelial protein C receptor‐dependent protein C activation and accelerates thrombosis in vivo (2014) (7)
Defects in natural anticoagulant pathways as potential risk factors for myocardial infarction. (1997) (7)
Epitope-dependent selective targeting of thrombomodulin monoclonal antibodies to either surface or intracellular compartment of endothelial cells. (1998) (7)
Calcium inhibition of the activation of protein C by thrombin. Role of the P3 and P3' residues. (1994) (7)
Point Mutations in the Endothelial Protein C Receptor (EPCR) Promoter (2002) (7)
Dysregulation of the Microvasculature in Nonlesional Non-Sun-exposed Skin of Patients with Lupus Nephritis (2012) (6)
Analysis of protein C and protein S in disease states. (1987) (6)
Sepsis. A myriad of responses. (2001) (6)
The Conversion of Prothrombin to Thrombin: The Function of the Propiece of Prothrombin (1975) (6)
Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells (2016) (6)
A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis (2020) (6)
Proteinase-3 and CD 11 b / CD 18 Binds to Activated Neutrophils : Involvement The Soluble Endothelial Protein C Receptor (2000) (6)
An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice (2021) (5)
The relationship between thrombomodulin expression and cell cycle stages in cultured rabbit endothelial cells. (1984) (5)
Activated Protein C has a Regulatory Role in Factor VIII Function. (2021) (5)
Influence of endothelial cell protein C receptor on plasma clearance of factor VIIa (2012) (5)
Natural Anticoagulants and Their Pathways (1999) (5)
Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ (2012) (4)
Inflammation and coagulation (2005) (4)
Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging (2021) (4)
potential functional implications Endothelial cell protein C receptor cellular localization and trafficking (2014) (4)
Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet‐dependent and ‐independent mechanisms (2020) (4)
Thrombin spatial distribution determines Protein C activation during hemostasis and thrombosis. (2021) (4)
Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus Pneumoniae-induced Pleural Fibrosis. (2021) (4)
damage initiated by Escherichia coli without preventing shock or organ DEGR-factor Xa blocks disseminated intravascular coagulation (2011) (4)
Regulation of Complement Activation by Thrombomodulin. (2009) (4)
The molecular weight and oligomerization of rabbit thrombomodulin as assessed by sedimentation equilibrium. (1989) (4)
A myriad of responses (2001) (4)
Complex Interaction between Factor Va‐Light Chain and Thrombomodulin in the Regulation of Protein C Activation a (1986) (4)
Initiation of clot lysis in plasma by activated protein C (1978) (3)
Crosstalk Between Inflammation and Thrombosis: The Surprising Role of Extracellular Histones (2010) (3)
Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy. (2022) (3)
Assembly and Function of the Protein C Anticoagulant Pathway on Endothelium (1988) (3)
Associated with Recurrent Thrombosis (1984) (3)
Adherent Mononuclear Cells And Activated Protein C (APC) (1981) (3)
Biochemical and physiological aspects of protein C (1984) (3)
In Vitro Prothrombin Synthesis - The Vitamin K-Dependent Carboxylation of a Prothrombin Precursor (1975) (3)
Dimorphisms in the membrane-spanning domain of EPCR impact systemic coagulation. (2009) (2)
Effect of Human Plasma-Derived Protein C and Murine Recombinant Protein C on Severe Neonatal Sepsis in Mice. (2004) (2)
Introduction: Cellular regulation of blood coagulation (1995) (2)
Modulation of the Protein C Pathway as a Therapy for Thrombosis (2002) (2)
Role of sequestration-induced loss of protein C receptors in coagulation and inflammation in cerebral malaria (2014) (2)
EPCR/PAR1 Signaling Navigates Long-Term Repopulating Hematopoietic Stem Cell Bone Marrow Homing to Thrombomodulin-Enriched Blood Vessels (2015) (2)
Insights Into the Mechanism of Zymogen Protein C Protection Against Cancer Progression (2012) (1)
2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex (2004) (1)
The Endothelial Protein C Receptor Supports TF-VIIa-Xa Ternary Complex Signaling through Protease-Activated Receptors. (2010) (1)
Plasma glycolipids levels: new factors regulating the protein C anticoagulant pathway and determining thrombotic risk. (2001) (1)
Dysregulation of the Microvasculature in Nonlesional Non-Sun-exposed Skin of Patients with Lupus Nephritis (2012) (1)
Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway (2013) (1)
DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis (2016) (1)
Inverse PAR1 Activity of Hematopoietic Stem Cells and BM Stromal Cells Mediates G-CSF-Induced Mobilization By Regulation of Nitric Oxide Generation (2016) (1)
Coagulation and Innate Immunity (2004) (1)
Loss of protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria [abstract] (2013) (1)
Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice (2012) (1)
In Vivo hemostatic Significance of Activated Protein C in Factor VIIIa Regulation (2019) (1)
154. Inflammation — the protein C pathway (1996) (1)
EPCR Guides Hematopoietic Stem Cells Homing to the Bone Marrow Independently of Niche Clearance (2016) (1)
Platelets are anticoagulants (2003) (1)
EPCR Limits Nitric Oxide Levels, Mediating Human and Murine Stem Cell Adhesion and Retention In The Bone Marrow, By Conjugating PAR1 and CXCR4 Signaling (2013) (1)
Fatal Liver Injury Death through TLR2 and TLR4 in Mouse Extracellular Histones Are Mediators of (2011) (0)
PAR-3 Activation by Activated Protein C: a Novel Podocyte Protective Signalling Pathway (2010) (0)
Introduction to the Fifth Margaux Conference on Critical Illness: Protein C pathways: Bedside to bench (2004) (0)
ENDOGENOUS PROTEIN C INHIBITS PULMONARY COAGULATION BUT FACILITATES BACTERIAL DISSEMINATION IN THE EARLY PHASE OF PNEUMOCOCCAL PNEUMONIA IN MICE (2007) (0)
ANTI-EPCR ANTIBODY EXACERBATES THE HEMOSTATIC AND INFLAMMATORY RESPONSES AND ENDOTHELIAL INJURY RESPONSE TO SUBLETHAL E. COLI (1999) (0)
EPCR Deficiency Prevents Development of Hemophilic Arthropathy (2019) (0)
Kinetic Analysis Of Prothrombin Activation By Des (l-44) Factor Xa (1981) (0)
CD73-generated Adenosine Regulates Thrombomodulin Expression (94.29) (2009) (0)
Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex (2002) (0)
barrier enhancement mediated vascular endothelial - sphingosine-1-phosphate receptor 1 Endogenous activated protein C limits cancer cell extravasation through (2013) (0)
Table of Contents (1990) (0)
Plasma sEPCR levels of patients with culture proven melioidosis. (2013) (0)
Corrections - Purification of an Apparent Rat Liver Prothrombin Precursor: Charcterization and Comparison to Normal Rat Prothrombin. (1975) (0)
Molecular basis of anticoagulation with oral anticoagulants (2009) (0)
Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule (2002) (0)
Modulators of the Protein C Pathway (2016) (0)
Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes (2018) (0)
Protease inhibitors of human plasma. Protein-C. (1985) (0)
Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C. (2002) (0)
THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN (1998) (0)
Rare but Relevant Kidney Disorders (2009) (0)
10th International Winter Meeting on Coagulation. Basic, Laboratory and Clinical Aspects of Venous and Arterial Thromboembolic Diseases. Bormio, Italy, April 10-16, 2011 (2012) (0)
CHARACTERIZATION OF THE RESPONSE TO E. COLI IN THE BABOON. (ROLES OF TNF, TF,AND PROTEIN C) (1988) (0)
IN VIVO BEHAVIOR OF DETERGENT SOLUBILIZED PURIFIED RABBIT THROMBOMODULIN INJECTED INTO RABBITS (1987) (0)
Table of Contents (1996) (0)
ENDOTHELIAL PROTEIN C RECEPTOR EXPRESSION IN BREAST CANCER (2007) (0)
Altered Phospholipid Specificity Increased Anticoagulant Activity and Prothrombin Gla Domain Exhibits A Chimeric Protein C Containing the STRUCTURE (2014) (0)
Function of Beta2-GPI in Inhibiting the Oxidized Phospholipids Dependent APC Activity by Antiphospholipid IgG from APS Patients. (2006) (0)
Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C (2022) (0)
"Protective effect of Human-Derived Protein C in Septic Neonatal Mice." (2005) (0)
Therapeutic application of activated Protein C epigenetically constrains the redox-enzyme p66shc in diabetic nephropathy (2013) (0)
Evidence for the important role of inflammation in xenotransplantation (2019) (0)
Cardiovascular and Cerebrovascular Aging — New Mechanisms and Insights Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis (2014) (0)
Inhibiting the growth of tumors by blocking the protein C system (1990) (0)
Open Research Online Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice (2022) (0)
The World of Pacing and Electrophysiology (2004) (0)
The Conversion of Prothrombin to Thrombin II (2002) (0)
2-glycoprotein I monoclonal antibodies β Inhibition of APC anticoagulant activity on oxidized phospholipid by anti- (2013) (0)
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site (2001) (0)
Factor VIIa Interaction with Endothelial Cell Protein C Receptor: Its Role in Hemostatic Effect of rFVIIa in Treating Hemophilia (2016) (0)
EPCR Signaling Controls the Activity of Hematopoietic Stem Cells Independent of Coagulation Regulation (2021) (0)
Abstract (2003) (0)
The structure of endothelial protein C receptor identifies the binding sites for protein C and reveals a bound lipid molicule (2002) (0)
Human activated protein C (1997) (0)
Diagnostic techniques using soluble receptor protein c / activated protein C endothelial cells. (1998) (0)
STUDIES ON A NEW THROMBIN DEPENDENT ANTICOAGULANT PATHWAY1 (1985) (0)
Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of Vitamin K-Dependent clotting and anticlotting Proteins (2011) (0)
9th International Winter Meeting on Coaugulation (2009) (0)
factor VIIa and activated protein C Factor X binding to endothelial cell protein C receptor: comparison with (2013) (0)
coagulant response to Escherichia coli Role of free protein S and C4b binding protein in regulating the (2011) (0)
Protein C in murine neonatal sepsis (2005) (0)
W14-O-001 EPCR genotype 6936A>G (SER219GLY): Reduced apc generation in GLY homozygotes with type 2 diabetes (2005) (0)
Ethanol Inhibits Thrombin-induced Secretion of the Contents of Human Platelet Dense and O-Granules and Lysosomes Thromb (2017) (0)
Protein C anticoagulant system—anti-inflammatory effects (2011) (0)
CD73-generated Adenosine Regulates Thrombomodulin Expression (2009) (0)
Molecular Events in the Activation of Bovine Factor V (1979) (0)
Prothrombin Binding” to Phospholipid Vesicle Surfaces and Phospholipid Acceleration of Prothrombin Activation (1975) (0)
Blocking EPCR decreases tumor growth of human breast cancer cells. (2013) (0)
respiratory pathogens and lipopolysaccharide Activated Protein C have an unaltered pulmonary immune response to Thrombomodulin mutant mice with a strongly reduced capacity to generate (2010) (0)
ENDOTHELIUM AND PROTEIN S: SYNTHESIS, RELEASE AND REGULATION OF ANTICOAGULANT ACTIVITY (1987) (0)
Interactions of plasmin with tissue factor pathway inhibitor (TFPI) in a mouse model of endotoxemia (2009) (0)
Abstract 14215: A Novel Thrombin Interacting Partner Emerges in Heart Failure (2011) (0)
The Centre for Bl oo d Research presents (2012) (0)
The structure of des-F1-meizothrombin: the nature and location of kringle-thrombin and kringle-kringle interactions (1993) (0)
Extracellular histones function as alarmins in hepatic ischemia/reperfusion injury through toll-like receptor 9 (2011) (0)
Extracellular Histones Mediate Hepatic Ischemia-Reperfusion Injury Through A Toll-like Receptor 9-dependent Pathway (2011) (0)
Interaction of Factor VIIa with Endothelial Cell Protein C Receptor: Differences Between the Human and Mouse Systems (2011) (0)
protease-activated receptor-3 in podocytes Cytoprotective signaling by activated protein C requires (2012) (0)
Myeloid-Derived Suppressor Cells Encephalomyelitis by Inducing Attenuates Experimental Autoimmune Inhibition of Endogenous Activated Protein C (2013) (0)
Defects in the protein C pathway (1987) (0)
144B: ACTIVATED PROTEIN C AND OVEREXPRESSION OF ITS RECEPTOR INHIBIT TUMOR METASTASIS (2010) (0)
Glu-192-- GIn substitution in thrombin mimics the catalytic switch induced by thrombomodulin ( serine proteinases / substrate specificity / mutagenesis / protein engineering / structure-activity relationship ) (0)
Analysis of the proc gene in patients with type 2 diabetes and low levels of activated protein c (2012) (0)
Loss of thrombomodulin expression impairs vein graft thromboresistance (2002) (0)
Endothelial Cell Protein C Receptor-Mediated Redistribution and Tissue-Level Accumulation of Pharmacologically Administered Recombinant Human Factor VIIa (2011) (0)
Speakers and Chairmen (1970) (0)
Effect of overexpression of constitutively active Rab4A mutant on intracellular trafficking of FVIIa and EPCR. (2013) (0)
New methods may allow answers to old questions in vascular biology. (1992) (0)
Abstract (2003) (0)
Novel genetic predisposition to coronary heart disease associated with the protein C pathway (2005) (0)

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