Christine Van Broeckhoven
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Biology
Christine Van Broeckhoven's Degrees
- PhD Biomedical Sciences University of Antwerp
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(Suggest an Edit or Addition)Christine Van Broeckhoven's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease (2014) (1230)
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. (2003) (592)
- Genetic association of apolipoprotein E with age-related macular degeneration. (1998) (478)
- Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. (1998) (437)
- Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. (1998) (399)
- The role of tau (MAPT) in frontotemporal dementia and related tauopathies (2004) (319)
- Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. (1997) (314)
- Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology (2013) (308)
- A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN (2015) (246)
- Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites (2011) (191)
- Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease (2008) (149)
- A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. (2007) (148)
- Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. (2000) (136)
- Granulin mutations associated with frontotemporal lobar degeneration and related disorders: An update (2008) (135)
- The apolipoprotein E ε2 allele is associated with an increased risk of early‐onset alzheimer's disease and a reduced survival (1995) (130)
- Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects (2003) (123)
- Estrogen use and early onset Alzheimer's disease: a population-based study (1999) (114)
- Apolipoprotein E genotype in patients with alzheimer's disease: Implications for the risk of dementia among relatives (1995) (107)
- PRNP Val129 homozygosity increases risk for early‐onset Alzheimer's disease (2003) (106)
- Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease (2012) (106)
- Power of Selective Genotyping in Genetic Association Analyses of Quantitative Traits (2000) (99)
- APOE and the risk of PD with or without dementia in a population-based study (2000) (98)
- Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease (1995) (94)
- Progranulin locus deletion in frontotemporal dementia (2008) (93)
- Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansion. (1998) (91)
- Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His (2009) (88)
- Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression. (2000) (86)
- Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion. (1999) (86)
- Apolipoprotein E and Carotid Artery Atherosclerosis: The Rotterdam Study (2001) (84)
- Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder. (1997) (82)
- Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. (1996) (79)
- Non‐replication of the brain‐derived neurotrophic factor (BDNF) association in bipolar affective disorder: A Belgian patient‐control study (2004) (78)
- Apolipoprotein E gene and sporadic frontal lobe dementia (1997) (77)
- Alzheimer dementia caused by a novel mutation located in the APP C‐terminal intracytosolic fragment (2006) (77)
- Cerebral amyloid angiopathy is a pathogenic lesion in Alzheimer's disease due to a novel presenilin 1 mutation. (2001) (76)
- Familial clustering and genetic risk for dementia in a genetically isolated Dutch population. (2004) (72)
- Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe (2003) (71)
- Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11. (1994) (68)
- 5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait. (2000) (68)
- Assignment of X-linked hydrocephalus to Xq28 by linkage analysis. (1990) (66)
- The impact of APOE on myocardial infarction, stroke, and dementia (2004) (64)
- Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population. (2005) (63)
- Comparative study of microsatellite and cytogenetic markers for detecting the origin of the nondisjoined chromosome 21 in Down syndrome. (1992) (61)
- Octapeptide repeat insertions in the prion protein gene and early onset dementia (2004) (61)
- Genetics of personality: are we making progress? (2003) (60)
- Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam Study. (1998) (59)
- Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders. (2002) (58)
- Primary and secondary structure of the 18S ribosomal RNA of the bird spider Eurypelma californica and evolutionary relationships among eukaryotic phyla. (1988) (58)
- Apolipoprotein E genotype and progression of Alzheimer’s disease: the Rotterdam Study (1999) (58)
- Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor protein gene (APP692). (2000) (56)
- Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia. (2001) (56)
- Shared genetic contribution to ischemic stroke and Alzheimer's disease (2016) (55)
- CAG repeat expansions in bipolar and unipolar disorders. (1997) (55)
- The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease. (1999) (55)
- The α2-macroglobulin gene in AD (2000) (55)
- Identification and localization of ataxin-7 in brain and retina of a patient with cerebellar ataxia type II using anti-peptide antibody. (1999) (55)
- Further localization of X-linked hydrocephalus in the chromosomal region Xq28. (1992) (55)
- Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4. (1996) (54)
- Absence of linkage between chromosome 11p15 markers and manic-depressive illness in a Belgian pedigree. (1991) (53)
- Report of the chromosome 18 workshop. (1999) (49)
- A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder. (2000) (47)
- Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients. (1997) (46)
- Early cognitive decline is associated with prion protein codon 129 polymorphism (2003) (43)
- Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies (2006) (42)
- The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. (1995) (41)
- Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. (2002) (40)
- A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21. (1994) (40)
- The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study. (1999) (40)
- Positive association between the GABRA5 gene and unipolar recurrent major depression. (1997) (40)
- The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality (2003) (39)
- Update on chromosomal locations for psychiatric disorders: report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, California, October 14-18, 1999. (2000) (39)
- Primary and secondary structure of the 18 S ribosomal RNA of the insect species Tenebrio molitor (1988) (38)
- A study of the SORL1 gene in Alzheimer's disease and cognitive function. (2009) (38)
- APOE epsilon4 and Alzheimer's disease: positive association in a Colombian clinical series and review of the Latin-American studies. (2001) (33)
- Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation. (2000) (32)
- Large meta-analysis of genome-wide association studies expands knowledge of the genetic etiology of Alzheimer disease and highlights potential translational opportunities (2020) (32)
- Linkage of mood disorders with D2, D3 and TH genes: a multicenter study. (2000) (32)
- Genetic and physical characterization of the early-onset Alzheimer's disease AD3 locus on chromosome 14q24.3. (1995) (31)
- A linkage study between bipolar disorder and genes involved in dopaminergic and GABAergic neurotransmission (1996) (30)
- Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS (2017) (29)
- Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease. (2001) (29)
- Patient-control association study of substance P-related genes in unipolar and bipolar affective disorders. (2005) (27)
- Association study between bipolar disorder and candidate genes involved in dopamine-serotonin metabolism and GABAergic neurotransmission: a preliminary report. (1996) (27)
- The cystatin C polymorphism is not associated with early onset Alzheimer’s disease (2001) (27)
- Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in Down syndrome. (1998) (27)
- Apolipoprotein E4 in the temporal variant of frontotemporal dementia (2002) (26)
- Evidence for Allelic Heterogeneity in Familial Early-Onset Alzheimer's Disease (1991) (25)
- Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study. (2002) (25)
- Two sequence-ready contigs spanning the two copies of a 200-kb duplication on human 21q: partial sequence and polymorphisms. (1998) (24)
- A yeast artificial chromosome contig from human chromosome 14q24 spanning the Alzheimer's disease locus AD3. (1995) (24)
- A high-resolution physical map of human chromosome 21p using yeast artificial chromosomes. (1999) (23)
- Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease (2012) (22)
- Chromosome 18 workshop. (1998) (22)
- Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3. (1999) (21)
- APOLIPOPROTEIN E AND LONGEVITY: THE ROTTERDAM STUDY (2001) (21)
- Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case–control study (2003) (21)
- Linkage analysis of bipolar illness with X-chromosome DNA markers: a susceptibility gene in Xq27-q28 cannot be excluded. (1994) (21)
- Localization of a gene responsible for nonspecific mental retardation (MRX9) to the pericentromeric region of the X chromosome. (1993) (20)
- Genomic organisation of the spinocerebellar ataxia type 7 (SCA7) gene responsible for autosomal dominant cerebellar ataxia with retinal degeneration (1999) (20)
- D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21. (1992) (19)
- The alpha2-macroglobulin gene in AD: a population-based study and meta-analysis. (2000) (19)
- Cloning and characterization of a 135- to 500-kb region of homology on the long arm of human chromosome 21. (1994) (18)
- Genetic testing should not be advocated as a diagnostic tool in familial forms of dementia. (2000) (15)
- Arginine vasopressin receptor gene-based single-nucleotide polymorphism analysis in attention deficit hyperactivity disorder (2009) (15)
- High-resolution physical mapping of a 6.7-Mb YAC contig spanning a region critical for the monosomy 21 phenotype in 21q21.3-q22.1. (1997) (14)
- Mapping of the gene for X-linked liver glycogenosis due to phosphorylase kinase deficiency to human chromosome region Xp22. (1991) (14)
- Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population (2004) (14)
- Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease (2001) (14)
- Report and abstracts of the Sixth International Workshop on Human Chromosome 21 Mapping 1996. Cold Spring Harbor, New York, USA. May 6-8,1996. (1997) (13)
- Identification of a 4 bp deletion (1560de14) in Po gene in a family with severe charcot‐Marie‐Tooth disease (1996) (13)
- A contiguous physical map of the pericentromeric region of chromosome 21q between D21Z1 and D21S13E. (1993) (12)
- Lack of association between GABRA3 and unipolar affective disorder: a multicentre study. (2001) (12)
- Manic-depressive illness and linkage reanalysis in the Xq27-Xq28 region of chromosome X. (1995) (12)
- Unique sequence homology in the pericentromeric regions of the long arms of chromosomes 13 and 21. (1992) (12)
- Linkage of DNA markers at Xq28 to adrenoleukodystrophy and adrenomyeloneuropathy present within the same family. (1990) (11)
- A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder. (1997) (9)
- PCR detection of two RFLP's at the D21S13 locus. (1990) (9)
- The pericentromeric 21 DNA marker pGSM21 (D21S13) contains an expressed HTF island. (1990) (7)
- DNA fingerprints revealing common and divergent human DNA methylation patterns (1989) (7)
- A new (CA)n repeat polymorphism at the D21S13E locus. (1991) (6)
- YAC fragmentation with repetitive and single-copy sequences: detailed physical mapping of the presenilin 1 gene on chromosome 14. (1999) (6)
- A polymorphic locus [D21S144] is detected by probe pVC12 on chromosome 21. (1989) (6)
- Dinucleotide repeat polymorphism at the D21S258 locus. (1992) (6)
- The TNFRSF6 gene is not implicated in familial early-onset Alzheimer's disease. (2001) (5)
- Study of the origin of nondisjunction in a family with two cases of Down syndrome using cytogenetic and molecular polymorphisms. (2005) (4)
- PCR detection of the frequent TaqI RFLP at locus D21S13E. (1991) (4)
- Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case–control study (2006) (4)
- Expanded RED products and loci containing CAG/CTG repeats on chromosome 17 (ERDA1) and chromosome 18 (CTG18.1) in trans‐generational pairs with bipolar affective disorder (2004) (4)
- Comment - Genes and temperament, a shortcut for unravelling the genetics of psychopathology? (1998) (3)
- TheTNFRSF6 gene is not implicated in familial early-onset Alzheimer's disease (2001) (2)
- A high frequency EcoRI RFLP detected at the D21S13 locus. (1990) (2)
- Dinucleotide repeat polymorphism at the D21S145 locus. (1992) (2)
- Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder (2007) (2)
- Correction: Clinical, neuropathological, and genetic characterization of STUB1 variants in cerebellar ataxias: a frequent cause of predominant cognitive impairment (2020) (2)
- The reactions of mercurated pyrimidine nucleotides with thiols and with hydrogen sulfide. (1978) (2)
- Author Correction: Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS (2018) (2)
- Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-negative dementia family (2004) (2)
- Two polymorphic loci are detected simultaneously by probe CARLP II8.2 [D10S21] on chromosome 10. (1988) (2)
- Dinucleotide repeat polymorphism at the D21S16 [correction of D1S16] locus. (1992) (1)
- A highly polymorphic locus is detected by probe CARLP II6.3 [D5S88]. (1988) (1)
- [A Pair of Siblings with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and a Novel Thr462Lysfs Mutation in the TBK1 Gene]. (2016) (1)
- Separation of oligoribonucleotides by high performance liquid chromatography [proceedings]. (1979) (0)
- Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity (2020) (0)
- Association between major depressive disorder and a specific haplotype of the CRH binding protein gene (2002) (0)
- Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects (2003) (0)
- LINKAGE STUDIES IN MANIC DEPRESSIVE ILLNESS. (1992) (0)
- HPA axis dysfunction in psychiatry: Genetic background (2007) (0)
- Synthesis and properties of 5-thiomercuri derivatives of pyrimidine nucleotides [proceedings]. (1977) (0)
- A polymorphic locus [D1S88] is detected by probe LA01.41 on chromosome 1p. (1989) (0)
- The &agr;2-macroglobulin gene in AD: A population-based study and meta-analysis (2000) (0)
- [Genetic coupling study using DNA markers in the familial form of Alzheimer's disease]. (1989) (0)
- [Genetic findings in degenerative dementia]. (1989) (0)
- Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease (2018) (0)
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