Carl Cotman
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Most Influential Person Now
American neuroscientist
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Carl Cotmanbiology Degrees
Biology
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#1881
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#573
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Neuroscience
#69
World Rank
#73
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#30
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Biology
Carl Cotman's Degrees
- PhD Neurobiology University of California, Irvine
- Bachelors Biology University of California, Irvine
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Why Is Carl Cotman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Carl Wayne Cotman is an American neuroscientist. He is a professor of neurology at the University of California, Irvine School of Medicine, where he is also the founding director of the Institute for Brain Aging and Dementia and the Institute for Memory Impairments and Neurological Disorders . He is known for researching the neurochemistry of Alzheimer's disease and other forms of dementia. His research has shown, for example, that physical exercise increases production of brain-derived neurotropic factor, which protects neurons from aging-related damage and promotes the growth of new ones.
Carl Cotman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis (2003) (3868)
- Exercise: a behavioral intervention to enhance brain health and plasticity (2002) (2535)
- A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. (1997) (2355)
- The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. (1989) (2181)
- Exercise builds brain health: key roles of growth factor cascades and inflammation (2007) (1908)
- Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease (2011) (1656)
- Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state (1993) (1436)
- Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain (1985) (1277)
- Exercise and brain neurotrophins (1995) (1066)
- Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. (1993) (1050)
- Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain (1996) (1029)
- A microfluidic culture platform for CNS axonal injury, regeneration and transport (2005) (1011)
- Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. (1992) (977)
- Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease: A Randomized Controlled Trial (2000) (905)
- Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors (1984) (878)
- The neurobiology of learning and memory (1989) (828)
- In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity (1991) (812)
- Anatomical organization of excitatory amino acid receptors and their pathways (1987) (795)
- Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease (2005) (773)
- Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells (1978) (717)
- Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers (2007) (709)
- Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity (1995) (646)
- β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage (1990) (642)
- Immunohistochemical evidence for apoptosis in Alzheimer's disease. (1994) (611)
- Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization. (1971) (597)
- Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo (1988) (591)
- Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid (2002) (548)
- Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists (1986) (547)
- High, usual and impaired functioning in community-dwelling older men and women: findings from the MacArthur Foundation Research Network on Successful Aging. (1993) (525)
- Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites (1983) (514)
- Excitatory amino acids in the brain - focus on NMDA receptors (1987) (499)
- Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. (2004) (498)
- Gene expression changes in the course of normal brain aging are sexually dimorphic (2008) (486)
- The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography (1982) (484)
- Synapse replacement in the nervous system of adult vertebrates. (1981) (482)
- Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site. (1982) (479)
- Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions (2010) (475)
- Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. (1988) (472)
- Plasticity of hippocampal circuitry in Alzheimer's disease. (1985) (471)
- An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration (1976) (461)
- Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions. (1972) (459)
- Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus (2005) (452)
- Neurobiology of exercise (2006) (450)
- Amyloid beta protein enhances the survival of hippocampal neurons in vitro. (1989) (448)
- Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease (1991) (448)
- Neurobiology of Exercise (2006) (421)
- DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delay (1996) (419)
- Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate (1979) (417)
- Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression (1999) (403)
- Exercise Enhances and Protects Brain Function (2002) (394)
- Clinical and pathological evidence for a frontal variant of Alzheimer disease. (1999) (390)
- Evolution in the Conceptualization of Dementia and Alzheimer’s Disease: Greco-Roman Period to the 1960s (1998) (385)
- Emergence of artistic talent in frontotemporal dementia (1998) (382)
- Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. (1998) (380)
- Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid (1980) (379)
- Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity (1983) (379)
- Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor (1989) (378)
- Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study (2012) (378)
- Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen (1989) (370)
- Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection (1992) (369)
- Exercise and time-dependent benefits to learning and memory (2010) (369)
- The distribution of septal projections to the hippocampus of the rat (1973) (367)
- Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus (2000) (367)
- Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine. (1988) (365)
- An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts (1976) (359)
- Estrogen and exercise interact to regulate brain‐derived neurotrophic factor mRNA and protein expression in the hippocampus (2001) (339)
- A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat. (1973) (334)
- Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. (2012) (328)
- beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. (1994) (327)
- Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons (2009) (327)
- Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord (1983) (324)
- Effects of Exercise on Gene-Expression Profile in the Rat Hippocampus (2001) (324)
- Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor. (1989) (323)
- Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. (2000) (320)
- Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. (1991) (316)
- Achieving and maintaining cognitive vitality with aging. (2002) (306)
- Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex (1981) (302)
- Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities (1997) (302)
- Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents (1976) (299)
- β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease (1996) (299)
- Isolation of synaptosomal and synaptic plasma membrane fractions. (1974) (291)
- Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. (1991) (291)
- β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease (1992) (286)
- Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression (2004) (284)
- Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro(*) (1995) (279)
- Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease (2011) (274)
- Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults (1995) (273)
- Patterned cell culture inside microfluidic devices. (2005) (272)
- Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. (2003) (270)
- Mechanisms of Neuronal Death in Alzheimer's Disease (1996) (269)
- Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity (1995) (267)
- The canine as an animal model of human aging and dementia (1996) (267)
- Exercise counteracts declining hippocampal function in aging and Alzheimer's disease (2013) (264)
- The exercise-induced expression of BDNF within the hippocampus varies across life-span (2005) (263)
- Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance? (1998) (262)
- Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid (1980) (259)
- ISOLATION AND STRUCTURAL STUDIES ON SYNAPTIC COMPLEXES FROM RAT BRAIN (1972) (257)
- Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain (2002) (251)
- Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. (1995) (247)
- Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiography (1984) (245)
- Bax Protein Expression Is Increased in Alzheimer's Brain: Correlations with DNA Damage, Bcl‐2 Expression, and Brain Pathology (1997) (244)
- Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide (1978) (242)
- Evaluation of glutamate as a neurotransmitter of cerebellar parallel fibers (1978) (241)
- Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors (1993) (239)
- Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies (1993) (236)
- Lipid composition of synaptic plasma membranes isolated from rat brain by zonal centrifugation. (1969) (236)
- Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. (2013) (232)
- In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. (1991) (229)
- Glutamate as transmitter of hippocampal perforant path (1977) (224)
- Cell biology of synaptic plasticity. (1984) (222)
- Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology (2001) (221)
- β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised* (2001) (219)
- ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT BRAIN (1974) (219)
- Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid (2008) (217)
- Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons (1994) (216)
- Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. (1992) (213)
- Developmental differences in post-lesion axonal growth in the hippocampus. (1973) (212)
- Localization and Cell Association of C1q in Alzheimer's Disease Brain (1996) (211)
- β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine (1996) (210)
- Caspase-3 activation as a bifurcation point between plasticity and cell death (2012) (209)
- The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise (2004) (209)
- Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation (1986) (208)
- Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. (2012) (208)
- Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition (2008) (207)
- Moderate to high-intensity physical exercise in patients with Alzheimer’s disease (2015) (204)
- NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons (1989) (202)
- Microfluidic Multicompartment Device for Neuroscience Research. (2003) (201)
- Rapid Communication: Ca2+ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture (1994) (200)
- Neuronotrophic activity in brain wounds of the developing rat. Correlation with implant survival in the wound cavity (1983) (199)
- Inflammatory changes parallel the early stages of Alzheimer disease (2007) (199)
- Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease (2013) (199)
- Synaptic localization of kainic acid binding sites (1981) (197)
- β-Amyloid protein promotes neuritic branching in hippocampal cultures (1990) (196)
- Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity. (1974) (196)
- Spine Loss and Regrowth in Hippocampus following Deafferentation (1974) (196)
- Synaptic rearrangement in the dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats. (1973) (195)
- Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease (2008) (194)
- An overview of glutamate as a neurotransmitter. (1981) (192)
- Early association of reactive astrocytes with senile plaques in Alzheimer's disease (1995) (191)
- Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease (2010) (190)
- Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal (1980) (190)
- Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease (1986) (189)
- Oxidative damage increases with age in a canine model of human brain aging (2002) (188)
- Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors (1992) (187)
- Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction (2008) (187)
- Measurement of free electrophoretic mobility and retardation coefficient of protein-sodium dodecyl sulfate complexes by gel electrophoresis. A method to validate molecular weight estimates. (1972) (186)
- Changes in the distribution of the dentate gyrus associational system following unilateral or bilateral entorhinal lesions in the adult rat (1976) (185)
- Neuronal Apoptosis Induced by β-Amyloid Is Mediated by Caspase-8 (1999) (183)
- Exercise improves cognition and hippocampal plasticity in APOE ε4 mice (2009) (182)
- β-Amyloid impairs axonal BDNF retrograde trafficking (2011) (182)
- The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology (2005) (181)
- Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. (2003) (181)
- Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain (1997) (181)
- The survival of brain transplants is enhanced by extracts from injured brain. (1984) (179)
- β-Amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease (1993) (179)
- Hypertrophy and redistribution of astrocytes in the deafferented dentate gyrus (1976) (178)
- β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons (2004) (178)
- Increased Immunoreactivity for Jun- and Fos-Related Proteins in Alzheimer's Disease: Association with Pathology (1994) (178)
- Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and gamma‐aminobutyric acid release. (1976) (177)
- Senile plaques as aberrant sprout-stimulating structures (1986) (176)
- β-Amyloid Induces Local Neurite Degeneration in Cultured Hippocampal Neurons: Evidence for Neuritic Apoptosis (1998) (176)
- Activation of Caspase-8 in the Alzheimer's Disease Brain (2001) (174)
- Voluntary wheel running improves recovery from a moderate spinal cord injury. (2005) (173)
- l-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis (1985) (173)
- Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. (2001) (172)
- Baclofen selectively inhibits excitatory synaptic transmission in the hippocampus (1981) (171)
- Induction of a neurite-promoting factor in rat brain following injury or deafferentation (1986) (171)
- The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. (2008) (170)
- Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. (2006) (170)
- Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus. (1986) (169)
- Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures. (1991) (168)
- Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons (1998) (168)
- Lesion‐induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and reacquisition of normal synaptic density (1982) (166)
- Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse (2007) (166)
- Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase (2012) (164)
- Physical activity and the maintenance of cognition: Learning from animal models (2007) (164)
- Loss and reacquisition of hippocampal synapses after selective destruction of CA3–CA4 afferents with kainic acid (1980) (162)
- Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction (2002) (159)
- Visual-discrimination learning ability and β-amyloid accumulation in the dog (1998) (157)
- Biochemical correlates of respiratory deficiency. VII. Glucose repression. (1966) (156)
- Amyloid β‐Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells (1995) (156)
- Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities. (1974) (155)
- Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. (2002) (155)
- Glutamate as a CNS transmitter. II. Regulation of synthesis in the releasable pool (1979) (155)
- The Hippocampus as a Model for Studying Anatomical Plasticity in the Adult Brain (1975) (154)
- Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease (1992) (154)
- Elevated corticosterone levels. A possible cause of reduced axon sprouting in aged animals. (1984) (152)
- Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. (1992) (152)
- Age-related changes in excitatory amino acid receptors in two mouse strains (1993) (152)
- Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea‐pig hippocampus. (1986) (151)
- A quantitative autoradiographic and electrophysiological study of the reinnervation of the dentate gyrus by the contralateral entorhinal cortex following ipsilateral entorhinal lesions (1976) (150)
- Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. (2007) (149)
- The Cell surface and neuronal function (1980) (148)
- A potential role for apoptosis in neurodegeneration and Alzheimer's disease (1995) (148)
- beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. (1992) (147)
- Perforated postsynaptic densities: probable intermediates in synapse turnover. (1982) (146)
- β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease (1994) (146)
- The control of glial populations in brain: Changes in astrocyte mitogenic and morphogenic factors in response to injury (1985) (145)
- Spatial learning and memory as a function of age in the dog. (1995) (145)
- Exercise and Sodium Butyrate Transform a Subthreshold Learning Event into Long-Term Memory via a Brain-Derived Neurotrophic factor-Dependent Mechanism (2013) (144)
- Neuronotrophic factors for mammalian brain neurons: injury induction in neonatal, adult and aged rat brain. (1985) (144)
- Olfactory classical conditioning in neonates. (1991) (143)
- Postlesion Axonal Growth Produces Permanent Functional Connections (1973) (142)
- Identification of glycoproteins and proteins at synapses in the central nervous system. (1977) (142)
- EFFECTS OF ELEVATED [K+]0 ON THE RELEASE OF NEUROTRANSMITTERS FROM CORTICAL SYNAPTOSOMES: EFFLUX OR SECRETION? (1978) (141)
- β‐Amyloid Neurotoxicity In Vitro: Evidence of Oxidative Stress but Not Protection by Antioxidants (1997) (141)
- Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease (1998) (141)
- Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions: I. Time course after complete unilateral entorhinal lesion at various ages (1977) (140)
- Dietary enrichment counteracts age-associated cognitive dysfunction in canines (2002) (140)
- Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. (2010) (138)
- Differential Induction of Immediate Early Gene Proteins in Cultured Neurons by β‐Amyloid (Aβ): Association of c‐Jun with Aβ‐Induced Apoptosis (1995) (138)
- Region-specific age at onset of β-amyloid in dogs☆ (2000) (137)
- Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells (1996) (137)
- Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. (1989) (137)
- Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes (1995) (135)
- Hippocampal brain‐derived neurotrophic factor gene regulation by exercise and the medial septum (2002) (134)
- Lesions of the rat postsubiculum impair performance on spatial tasks. (1992) (133)
- Brain function, synapse renewal, and plasticity. (1982) (133)
- Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes. (1986) (133)
- Alzheimer's Presenilin-1 Mutation Potentiates Inositol 1,4,5-Trisphosphate-Mediated Calcium Signaling in Xenopus (1999) (132)
- Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy (2002) (132)
- Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons (1994) (130)
- Anatomical evidence for a projection from the entorhinal cortex to the contralateral dentate gyrus of the rat (1975) (130)
- Compensatory synapse growth in aged animals after neuronal death (1979) (129)
- Diffuse plaques contain C-terminal Aβ 42 and not Aβ 40: Evidence from cats and dogs (1996) (127)
- Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus (2001) (126)
- The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity (2003) (126)
- Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function (2007) (125)
- Olfactory tests as possible probes for detecting and monitoring Alzheimer's disease (1988) (124)
- Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs (2004) (124)
- Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment. (2012) (124)
- Frontal Lobe Volume, Function, and β-Amyloid Pathology in a Canine Model of Aging (2004) (124)
- Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity (1995) (123)
- Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo (1995) (123)
- Selective Loss of N‐Methyl‐d‐Aspartate‐Sensitive l‐[3H]Glutamate Binding Sites in Rat Brain Following Portacaval Anastomosis (1990) (122)
- Metabotropic Glutamate Receptor mGluR5 in Astrocytes: Pharmacological Properties and Agonist Regulation (1997) (121)
- Chloride and calcium ions reveal a pharmacologically distinct population of L-glutamate binding sites in synaptic membranes: correspondence between biochemical and electrophysiological data (1982) (121)
- Surface determinants of neuronal survival and growth on self-assembled monolayers in culture (1993) (120)
- Development of afferent lamination in the fascia dentata of the rat (1977) (120)
- Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study (2004) (120)
- TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions (2014) (119)
- LOCALIZATION AND CHARACTERIZATION OF CONCANAVALIN A RECEPTORS IN THE SYNAPTIC CLEFT (1974) (119)
- β-Amyloid neurotoxicity: A discussion of in vitro findings (1992) (119)
- Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation. (1991) (119)
- Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists (1992) (118)
- BIOCHEMICAL CORRELATES OF TRANSMISSION MEDIATED BY GLUTAMATE AND ASPARTATE (1978) (118)
- Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging (1998) (118)
- Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease. (1988) (118)
- Decrease in adrenergic axon sprouting in the senescent rat. (1978) (118)
- Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. (1996) (118)
- Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells (2009) (117)
- Subcellular fractionation of cultured glial cells. (1971) (117)
- Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease (2011) (116)
- 2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus (1984) (115)
- Induction of basic fibroblast growth factor in Alzheimer's disease pathology. (1990) (115)
- Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia (2006) (115)
- Horseradish peroxidase histochemistry: a new method for tracing efferent projections in the central nervous system. (1974) (113)
- Action of 3-((±)-2-car☐ypiperazin-4-yl)-propyl-1-phosphonic aci (CPP): a new and highly potent antagonist of N-methyl-d-aspartate receptors in the hippocampus (1986) (113)
- Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. (2002) (113)
- Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. (1995) (112)
- Physiological studies of the reciprocal connections between the hippocampus and entorhinal cortex (1975) (112)
- Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation. (1988) (111)
- Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture. (1994) (111)
- Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro. (1995) (110)
- GDEE antagonism of iontophoretic amino acid excitations in the intact hippocampus and in the hippocampal slice preparation (1976) (110)
- β-Amyloid converts an acute phase injury response to chronic injury responses (1996) (110)
- PROTEINS OF THE POSTSYNAPTIC DENSITY (1974) (109)
- Development of N-methyl-D-aspartate excitotoxicity in cultured hippocampal neurons. (1989) (109)
- Comparison of the Effects of l‐Carnitine and Acetyl‐l‐Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats (2004) (109)
- Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year. (2013) (109)
- Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease (1992) (108)
- Activation of complement pathways after contusion-induced spinal cord injury. (2004) (107)
- Relocation and hyperdevelopment of the dentate gyrus commissural system after entorhinal lesions in immature rats. (1973) (106)
- Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog (2000) (105)
- DNA Damage and Activated Caspase-3 Expression in Neurons and Astrocytes: Evidence for Apoptosis in Frontotemporal Dementia (2000) (104)
- Experimental tests of hypotheses about neurochemical mechanisms underlying behavioral tolerance to the anticholinesterase, diisopropyl fluorophosphate. (1975) (104)
- NMDA receptor activation and early olfactory learning. (1988) (104)
- Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/Alzheimer's disease patients: an autoradiographic study (1994) (103)
- Distribution and mobility of lectin receptors on synaptic membranes of identified neurons in the central nervous system (1976) (102)
- The Induction of the TNFα Death Domain Signaling Pathway in Alzheimer's Disease Brain (2003) (102)
- Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease (2020) (101)
- N-Methyl-d-aspartate promotes the survival of cerebellar granule cells: Pharmacological characterization (1989) (101)
- Ultrastructural changes in synapses in the dentate gyrus of the rat during development (1973) (101)
- Reactive Synaptogenesis in the Adult Nervous System (1976) (101)
- Transneuronal Degeneration in the Spread of Alzheimer's Disease Pathology: Immunohistochemical Evidence for the Transmission of Tau Hyperphosphorylation (1997) (101)
- Calcium, membranes, aging, and Alzheimer's disease (1989) (101)
- A Monoclonal Antibody to Amyloid Precursor Protein Induces Neuronal Apoptosis (2000) (101)
- Response of Schaffer collateral-CA1 pyramidal cell synapses of the hippocampus to analogues of acidic amino acids (1982) (100)
- Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations? (1998) (100)
- CHARACTERIZATION OF PUTATIVE AMINO ACID TRANSMITTER RELEASE FROM SLICES OF RAT DENTATE GYRUS (1977) (100)
- Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites. (1994) (100)
- Stimulus-Coupled Secretion of γ-Aminobutyric Acid from Rat Brain Synaptosomes (1973) (100)
- β-Amyloid deposition and tau phosphorylation in clinically characterized aged cats (2005) (99)
- Bcl-2 Facilitates Recovery from DNA Damage after Oxidative Stress (1999) (99)
- Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury (1989) (98)
- Region specific neuron loss in the aged canine hippocampus is reduced by enrichment (2008) (98)
- Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker (1990) (98)
- Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury (1988) (97)
- Lesion‐induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response (1982) (97)
- Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD‐Like Pathology in Aged Transgenic Mice (2002) (97)
- Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease (2014) (97)
- [3H]CPP, a new competitive ligand for NMDA receptors. (1986) (96)
- 15-Deoxy-Δ12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-γ, induces neuronal apoptosis (2001) (95)
- Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. (2013) (95)
- Multiple Pathways of Apoptosis in PC12 Cells (1999) (95)
- Up‐regulation of Bcl‐2 is associated with neuronal DNA damage in Alzheimer's disease (1996) (95)
- Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease (2003) (95)
- Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain (1986) (94)
- Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in alzheimer hippocampus: A quantitative autoradiographic study (1993) (94)
- A neurophysiological analysis of commissural projections to dentate gyrus of the rat. (1975) (94)
- R-α-Lipoic acid and acetyl-l-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes (2007) (94)
- Transient lesion-induced increase of basic fibroblast growth factor and its receptor in layer VIb (subplate cells) of the adult rat cerebral cortex (1992) (94)
- β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1* (2013) (94)
- Complement Association with Neurons and β-Amyloid Deposition in the Brains of Aged Individuals with Down Syndrome (2001) (94)
- BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog (2010) (93)
- The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro (1979) (92)
- Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth (2007) (92)
- Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy (1990) (92)
- In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: relationship to performance on the Morris water maze. (1992) (92)
- Thrombin Attenuates Neuronal Cell Death and Modulates Astrocyte Reactivity Induced by β‐Amyloid In Vitro (1996) (92)
- Rational pattern design for in vitro cellular networks using surface photochemistry (1994) (91)
- Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-l-carnitine (2009) (91)
- Ultrastructural characterization of identified cholinergic neurons transplanted to the hippocampal formation of the rat (1986) (91)
- Adrenergic Receptors in Alzheimer’s Disease Brain: Selective Increases in the Cerebella of Aggressive Patients (1997) (90)
- Landmark discrimination learning in the dog. (1999) (89)
- CALCIUM‐DEPENDENT RELEASE OF EXOGENOUSLY LOADED γ‐AMINO‐[U‐14C]BUTYRATE FROM SYNAPTOSOMES: TIME COURSE OF STIMULATION BY POTASSIUM, VERATRIDINE, AND THE CALCIUM IONOPHORE, A23187 (1976) (89)
- Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate‐induced epileptic seizures (2000) (89)
- An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease (2012) (88)
- Plaque biogenesis in brain aging and Alzheimer's disease I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments (1996) (88)
- Dynamic changes of excitatory amino acid receptors in the rat hippocampus following transient cerebral ischemia (1989) (88)
- Olfactory memory in unmedicated schizophrenics (1993) (88)
- Distribution of basic fibroblast growth factor in the developing rat brain (1994) (88)
- Hydrocortisone administration retards axon sprouting in the rat dentate gyrus (1980) (87)
- Resolution of insoluble proteins in rat brain subcellular fractions. (1967) (87)
- β-Amyloid peptides induce degeneration of cultured rat microglia (1993) (87)
- Pentobarbital depression of stimulus-secretion coupling in brain--selective inhibition of depolarization-induced calcium-dependent release. (1977) (86)
- Temporal parameters of axon “sprouting” in the brain of the adult rat (1977) (86)
- Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid (1993) (86)
- Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus (2015) (85)
- Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death (2003) (85)
- Excitatory amino acid receptors in schizophrenia. (1993) (85)
- N-Acetylaspartylglutamate identified in the rat retinal ganglion cells and their projections in the brain (1987) (85)
- H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus (2016) (85)
- Replacement of damaged cortical projections by homotypic transplants of entorhinal cortex (1985) (85)
- Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata (1979) (84)
- Changes in excitatory amino acid modulation of phosphoinositide metabolism during development. (1990) (84)
- Evaluation of glutamate as a hippocampal neurotransmitter: Glutamate uptake and release from synaptosomes (1978) (84)
- Electroshock Effects on Brain Protein Synthesis: Relation to Brain Seizures and Retrograde Amnesia (1971) (84)
- Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord (2007) (83)
- Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide. (2000) (82)
- Voltage‐gated currents expressed by rat microglia in culture (1992) (82)
- Recovery of spontaneous alternation following lesions of the entorhinal cortex in adult rats: possible correlation to axon sprouting. (1977) (82)
- [3H]TCP binding sites in Alzheimer's disease (1987) (82)
- Anatomical organization of excitatory amino acid receptors and their properties. (1986) (82)
- Neuronotrophic activity for ciliary ganglion neurons. Induction following injury to the brain of neonatal, adult, and aged rats. (1985) (81)
- Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy* (2014) (80)
- The progression of β-amyloid deposition in the frontal cortex of the aged canine (1997) (80)
- Characteristics of different amino acids as protein precursors in mouse brain: advantages of certain carboxyl-labeled amino acids. (1971) (80)
- A new type of lesion-induced synaptogenesis: I. Synaptic turnover in non-denervated zones of the dentate gyrus in young adult rats (1981) (80)
- Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione. (1991) (80)
- Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. (1999) (79)
- Chloride ions enhance L-glutamate binding to rat brain synaptic membranes (1982) (79)
- Neuritic Involvement within bFGf Immunopositive Plaques of Alzheimer's Disease (1993) (79)
- Carbachol depresses synaptic responses in the medial but not the lateral perforant path (1989) (79)
- Time-dependent changes in commissural field potentials in the dentate gyrus following lesions of the entorhinal cortex in adult rats (1975) (79)
- Effects of Conditioning Lesions on Transplant Survival, Connectivity, and Function (1987) (78)
- All-D-Enantiomers of β-Amyloid Exhibit Similar Biological Properties to All-L-β-Amyloids* (1997) (77)
- Immunocytochemical localization of glutaminase-like and aspartate aminotransferase-like immunoreactivities in the rat and guinea pig hippocampus (1985) (77)
- Autoradiography of d-2-[3H]amino-5-phosphonopentanoate binding sites in rat brain (1984) (77)
- A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity (2019) (77)
- Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I (1987) (77)
- Apolipoprotein‐E Genotyping of Diabetic Dementia Patients: Is Diabetes Rare in Alzheimer's Disease? (1996) (76)
- Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease (1994) (76)
- Strain-dependent decrease in glutamate binding to the N-methyl-d-aspartic acid receptor during aging (1989) (76)
- Glutamate and aspartate binding sites are enriched in synaptic junctions isolated from rat brain (1981) (75)
- Synthesis of [3H]2-Amino-4-phosphonobutyric acid and characterization of its binding to rat brain membranes: a selective ligand for the chloride/calcium-dependent class ofl-glutamate binding sites (1983) (75)
- Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. (1999) (75)
- Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury (2004) (75)
- Evidence for selective post-lesion axonal growth in the dentate gyrus of the rat. (1974) (74)
- Age-Specific Effects of Voluntary Exercise on Memory and the Older Brain (2013) (73)
- Developmental changes in morphology and molecular composition of isolated synaptic junctional structures (1981) (73)
- Excitatory amino acid receptors and ischemic brain damage in the rat (1987) (73)
- Development of Behavior (1980) (73)
- Emerging roles of oxidative stress in brain aging and Alzheimer's disease (2021) (73)
- Temporal and hippocampal metabolic rate during an olfactory memory task assessed by positron emission tomography in patients with dementia of the Alzheimer type and controls. Preliminary studies. (1991) (73)
- Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging (2009) (73)
- Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease (2016) (72)
- Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate β-amyloid(25–35) induced neurodegeneration in cultured hippocampal neurons (1995) (72)
- Stimulus evoked increase in the biosynthesis of the putative neurotransmitters glutamate in the hippocampus (1978) (71)
- Intracellular responses from granule cell layer in slices of rat hippocampus: perforant path synapse. (1976) (71)
- Factors affecting innervation in the CNS: comparison of three cholinergic cell types transplanted to the hippocampus of adult rats (1986) (71)
- Structure-function studies on N-oxalyl-diamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP is a selective non-NMDA agonist (1989) (71)
- Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain (2002) (71)
- Chloride and calcium ions separate L-glutamate receptor populations in synaptic membranes. (1983) (70)
- Astrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusion (2001) (70)
- Identification and distribution of axonal dystrophic neurites in Alzheimer's disease (1993) (70)
- N-methyl-d-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease (1992) (70)
- Low‐Dose Propranolol Reduces Aggression and Agitation Resembling That Associated with Orbitofrontal Dysfunction in Elderly Demented Patients (1995) (69)
- Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. (1993) (69)
- Visual-discrimination learning ability and beta-amyloid accumulation in the dog. (1998) (68)
- Neural-network-based classification of cognitively normal, demented, Alzheimer disease and vascular dementia from single photon emission with computed tomography image data from brain. (1995) (68)
- Possible Role of Apoptosis in Alzheimer's Disease (1994) (68)
- Protein and glycoprotein composition of synaptic junctions prepared from discrete synaptic regions and different species (1979) (68)
- Plaque biogenesis in brain aging and Alzheimer’s disease. II. Progressive transformation and developmental sequence of dystrophic neurites (1998) (67)
- Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to Alzheimer’ β amyloid peptide (2000) (67)
- Roles of Metabotropic Glutamate Receptors in Brain Plasticity and Pathology (1995) (67)
- Neurotransmitter characteristics of brain grafts: Striatal and septal tissues form the same laminated input to the hippocampus (1983) (66)
- Locomotor activity rhythms in dogs vary with age and cognitive status. (2003) (66)
- NGF receptor immunoreactivity in rat brain: Topographic distribution and response to entorhinal ablation (1987) (66)
- Effects of aging on NMDA and MK801 binding sites in mice (1993) (66)
- The Variability of Practice Hypothesis in Motor Learning: Does It Apply to Alzheimer's Disease? (2000) (65)
- High ciliary neuronotrophic specific activity in rat peripheral nerve (1984) (65)
- Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment (1999) (65)
- Tracing the dentate gyrus mossy fiber system with horseradish peroxidase histochemistry. (1973) (65)
- Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion (2003) (65)
- Cytokines and cytokine networks target neurons to modulate long-term potentiation. (2017) (65)
- Region-specific age at onset of beta-amyloid in dogs. (2000) (65)
- Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation (1991) (65)
- Effects of synaptic antagonists on perforant path paired-pulse plasticity: differentiation of pre- and postsynaptic antagonism (1985) (65)
- Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease (2007) (65)
- NGF receptor immunoreactivity in aged rat brain (1989) (64)
- Biochemical plasticity of short-axon interneurons: increased glutamate decarboxylase activity in the denervated area of rat dentate gyrus following entorhinal lesion. (1974) (63)
- Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in Xenopus (1999) (63)
- Carbachol increases intracellular free calcium in cultured rat microglia (1993) (63)
- Progress in Facilitating the Recovery of Function after Central Nervous System Trauma (1985) (63)
- Cooperation between nerve growth factor and laminin or fibronectin in promoting sensory neuron survival and neurite outgrowth. (1988) (63)
- Transplantation of fetal cholinergic neurons into the hippocampus attenuates the cognitive and neurochemical deficits induced by AF64A (1992) (62)
- Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain (1994) (62)
- Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress (2007) (62)
- Autoradiographic characterization of putative excitatory amino acid transport sites (1990) (62)
- Cyclic AMP-stimulated protein kinases at brain synaptic junctions. (1979) (61)
- Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease (1990) (61)
- Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia (2003) (61)
- Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome (2001) (61)
- The Role of Neurotrophins in Brain Aging: A Perspective in Honor of Regino Perez-Polo (2005) (61)
- Axonal sprouting at the neuromuscular junction of adult and aged rats (1981) (60)
- Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons (1987) (60)
- Acquisition and Long-Term Retention of a Fine Motor Skill in Alzheimers-Disease (1995) (60)
- Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration (1998) (60)
- Changes in protein levels in perfusates of freely moving cats: relation to behavioral state. (1975) (60)
- The Neuro-Immune Endocrine Connection (1987) (59)
- The specificity of reactive synaptogenesis: A comparative study in the adult rat hippocampal formation (1979) (59)
- An ultrastructural and chemical analysis of the effect of triton X-100 on synaptic plasma membranes. (1971) (59)
- Ultrastructural evidence of fibrillar β-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains (2000) (59)
- Molecular Dating of Senile Plaques in the Brains of Individuals with Down Syndrome and in Aged Dogs (2000) (58)
- Principles of Neuroanatomy (1981) (58)
- Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions: II. Effects of partial entorhinal and simultaneous multiple lesions (1977) (58)
- Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. (1992) (57)
- Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. (1993) (57)
- Progressive brain damage accelerates axon sprouting in the adult rat. (1977) (57)
- Culture and regeneration of human neurons after brain surgery (2001) (57)
- An analytical micro-method for electron microscopic study of the composition and sedimentation properties of subcellular fractions. (1970) (57)
- Calretinin-immunoreactive neurons are resistant to β-amyloid toxicity in vitro (1995) (57)
- Metallothionein-I and -III expression in animal models of Alzheimer disease (2006) (57)
- R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. (2008) (57)
- Pathologic concentrations of ammonium ions block l-glutamate uptake (1985) (56)
- Isolation of a membrane fraction enriched in nerve-end membranes from rat brain by zonal cetrifugation. (1968) (56)
- GADD45Is Induced in Alzheimer's Disease, and Protects against Apoptosisin Vitro (1998) (56)
- Development of a protocol for studying object recognition memory in the dog (2000) (56)
- Elevated NMDA receptors in parkinsonian striatum. (1992) (56)
- The Presence of Isoaspartic Acid in β-Amyloid Plaques Indicates Plaque Age (1999) (56)
- Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and α-synuclein pathology (2005) (56)
- Effect of serial lesions on sprouting in the dentate gyrus: Onset and decline of the catalytic effect (1978) (55)
- Regulation of muscarinic receptors in hippocampus following cholinergic denervation and reinnervation by septal and striatal transplants (1989) (55)
- Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat (1995) (55)
- Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. (1995) (54)
- Chronic glucocorticoid therapy alters axon sprouting in the hippocampal dentate gyrus (1982) (54)
- Glutamate as a CNS Neurotransmitter: Properties of Release, Inactivation and Biosynthesis (1978) (54)
- Enhancement of spatial-temporal reasoning after a Mozart listening condition in Alzheimer's disease: a case study. (1998) (54)
- Cultured Rat Microglia Express C1q and Receptor for C1q: Implications for Amyloid Effects on Microglia (1995) (54)
- Open Field Activity and Human Interaction as a Function of Age and Breed in Dogs (1997) (53)
- Decreases in protease nexins in Alzheimer's disease brain (1995) (53)
- Synaptic replacement in the dentate gyrus after unilateral entorhinal lesion: electron microscopic analysis of the extent of replacement of synapses by the remaining entorhinal cortex (1977) (53)
- Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state (1994) (52)
- Dopaminergic denervation of striatum results in elevated expression of NR2A subunit. (1996) (52)
- Acquisition and long-term retention of a gross motor skill in Alzheimer's disease patients under constant and varied practice conditions. (1996) (52)
- PL6.1 Keynote lecture: Exercise builds brain health: key roles of growth factor cascades and inflammation (2008) (52)
- Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms? (1990) (52)
- The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. (2003) (52)
- Selective alterations of RNA in rat hippocampus after entorhinal cortex lesioning. (1990) (52)
- Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. (1989) (52)
- Exercise enhances memory consolidation in the aging brain (2014) (52)
- The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2. (1991) (52)
- Isolation and characterization of insoluble proteins of the synaptic plasma membrane. (1968) (51)
- bFGF promotes the survival of entorhinal layer II neurons after perforant path axotomy (1992) (51)
- Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes (2012) (51)
- Synergistic Effects of Long-Term Antioxidant Diet and Behavioral Enrichment on β-Amyloid Load and Non-Amyloidogenic Processing in Aged Canines (2010) (51)
- Pathogenic amyloid β-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells (1999) (50)
- Life-Long Dietary Restriction Attenuates Age-Related Increases in Hippocampal Glial Fibrillary Acidic Protein mRNA (1997) (50)
- Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion. (1973) (50)
- Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease (2018) (50)
- Excitatory amino acid antagonists depress transmission in hippocampal projections to the lateral septum (1986) (50)
- Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. I. Positional and temporal factors (1980) (50)
- Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. (1996) (49)
- Molecular weights of the polypeptide chains of synaptic plasma membranes. (1972) (49)
- Decreased expression of N-methyl-d-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain (1997) (49)
- Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. (2002) (48)
- Gliotoxic actions of excitatory amino acids (1992) (48)
- Differential effects of interleukin-1β and interleukin-2 on glia and hippocampal neurons in culture (1995) (48)
- Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production (2014) (48)
- Neurobiological Models of Aging in the Dog and Other Vertebrate Species (2001) (48)
- A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture (1991) (47)
- Identification of a protein related to tubulin in the postsynaptic density. (1977) (47)
- Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease (1986) (47)
- Estrogen regulates bcl-x expression in rat hippocampus (2001) (47)
- Freezing eliminates a specific population of l-glutamate receptors in synaptic membranes (1983) (47)
- Re-establishment of electrophysiologically functional entorhinal cortical input to the dentate gyrus deafferented by ipsilateral entorhinal lesions: Innervation by the contralaeral entorhinal cortex (1973) (47)
- Plastic response of hippocampal excitatory amino acid receptors to deafferentation and reinnervation (1990) (47)
- Attenuation of β‐Amyloid Neurotoxicity In Vitro by Potassium‐Induced Depolarization (1996) (47)
- Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered. (1998) (47)
- A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: l-anti-endo-3,4-methanopyrrolidine dicarboxylate (1994) (46)
- Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX Trial): Rationale and Design (2013) (46)
- Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: Non-N-methyl-d-aspartate receptors (1992) (46)
- A microperfusion chamber for brain slice pharmacology (1983) (46)
- Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. (2008) (46)
- Carbohydrate composition of central nervous system synapses. Analysis of isolated synaptic junctional complexes and postsynaptic densities. (1976) (46)
- Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid (1981) (46)
- Possible Coordinated Gene Expressions for FGF Receptor, FGF-5, and FGF-2 Following Seizures (1995) (45)
- Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease. (1993) (45)
- A Novel Chloride‐Dependent L‐[3H]Glutamate Binding Site in Astrocyte Membranes (1987) (45)
- Effects of melatonin and age on gene expression in mouse CNS using microarray analysis (2007) (44)
- Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses (2017) (44)
- TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse (2018) (43)
- Transmitter phenotype is a major determinant in the specificity of synapses formed by cholinergic neurons transplanted to the hippocampus (1988) (43)
- Hydrocortisone administration alters glial reaction to entorhinal lesion in the rat dentate gyrus (1987) (43)
- Specificity of synaptic growth in brain: remodeling induced by kainic acid lesions. (1979) (43)
- Autoradiographic analysis of protein synthesis in synaptosomal fractions. (1971) (43)
- Growth of a new fiber projection in the brain of adult rats: Re-innervation of the dentate gyrus by the contralateral entorhinal cortex following ipsilateral entorhinal lesions (1974) (43)
- Differential regulation by beta-amyloid peptides of intracellular free Ca2+ concentration in cultured rat microglia. (1995) (42)
- Adult and embryonic frontal cortex transplants after frontal cortex ablation enhance recovery on a reinforced alternation task (1986) (42)
- A perfusion chamber for the study of CNS physiology and pharmacology in vitro (1978) (42)
- Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site (1987) (42)
- Amyloid βprotein precursor in cultured leptomeningeal smooth muscle cells (1994) (42)
- A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy. (2015) (41)
- A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog (2005) (41)
- Calcium-dependent γ-aminobutyrate release by interneurons of rat hippocampal regions: Lesion-induced plasticity (1977) (41)
- Exposure of Astrocytes to Thrombin Reduces Levels of the Metabotropic Glutamate Receptor mGluR5 (1996) (41)
- Do neurotrophic interactions control synapse formation in the adult rat brain? (1980) (40)
- Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors (1991) (40)
- Kainate receptors in the rat hippocampus: a distribution and time course of changes in response to unilateral lesions of the entorhinal cortex (1990) (40)
- Potentiation of the excitatory synaptic action of commissural, associational and entorhinal afferents to dentate granule cells (1977) (40)
- The identification of membrane glycocomponents in polyacrylamide gels: a rapid method using 125I-labeled lectins. (1977) (39)
- Distribution of fibroblast growth factor 5 mRNA in the rat brain: an in situ hybridization study (1993) (39)
- Parallel antagonism of synaptic transmission and kainate/quisqualate responses in the hippocampus by piperazine-2,3-dicarboxylic acid analogs (1986) (39)
- Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex (1996) (39)
- Initiation and propagation stages of β-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles (1998) (39)
- Intermolecular disulfide bonds at central nervous system synaptic junctions. (1976) (39)
- Effects of polyvalent cations on stimulus-coupled secretion of (14C)-gamma-aminobutyric acid from isolated brain synaptosomes. (1974) (39)
- A comparison of 2-amino-4-phosphonobutyric acid (AP4) receptors and [3H]AP4 binding sites in the rat brain (1986) (38)
- Analytical differential centrifugation: an analysis of the sedimentation properties of synaptosomes, mitochondria and lysosomes from rat brain homogenates. (1970) (38)
- Differentiation of serum‐free mouse embryo cells into astrocytes is accompanied by induction of glutamine synthetase activity (1995) (38)
- N-methyl-D-aspartate receptors and Alzheimer's disease (1989) (38)
- Cross-linking of Concanavalin A receptors on cortical neurons induces programmed cell death (1996) (38)
- Mild stress facilitates learning and exercise improves retention in aged mice (2011) (37)
- Long lasting changes in the spontaneous activity of hippocampal neurons following stimulation of the entorhinal cortex (1976) (37)
- Identification of Synapse Specific Components: Synaptic Glycoproteins, Proteins, and Transmitter Binding Sites (1981) (37)
- 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. (2001) (37)
- Laminin supports short‐term survival of rat septal neurons in low‐density, serum‐free cultures (1986) (37)
- Postsynaptic density antigens: preparation and characterization of an antiserum against postsynaptic densities (1981) (37)
- Inhibition of [3H]α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin β-N-oxaly-L-α,β-diaminopropionic acid (1988) (37)
- Subsynaptosomal distribution of enzymes involved in the metabolism of lipids. (1971) (37)
- Preferential adhesion of brain astrocytes to laminin and central neurites to astrocytes (1987) (36)
- Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs (2005) (36)
- Analysis of acetylcholinesterase synthesis and transport in the rat hippocampus: recovery of acetylcholinesterase activity in the septum and hippocampus after administration of diisopropylfluorophosphate. (1974) (36)
- Regulation of glutamate receptors: possible role of phosphatidylserine (1982) (36)
- Voluntary running attenuates age-related deficits following SCI (2008) (36)
- Injury induces presenilin-1 gene expression in mouse brain. (1996) (35)
- Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging (2005) (35)
- Mechanisms of septal lamination in the developing hippocampus analyzed by outgrowth of fibers from septal implants. II. Absence of guidance by degenerative debris (1982) (35)
- Regeneration of rat hippocampal fimbria fibers after fimbria transection and peripheral nerve or fetal hippocampal implantation (1983) (35)
- Exercise-induced gene expression changes in the rat spinal cord. (2005) (35)
- Perineuronal satellitosis in the human hippocampal formation (1993) (35)
- Isolated Executive Impairment and Associated Frontal Neuropathology (2004) (35)
- Identification of myosin in isolated synaptic junctions (1981) (35)
- Intracellular responses of rat dentate granule cellsin vitro: posttetanic potentiation to perforant path stimulation (1975) (34)
- A new type of lesion-induced synaptogenesis: II. The effect of aging on synaptic turnover in non-denervated zones (1981) (34)
- Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. (1994) (34)
- Differential regulation of inhibitors of apoptosis proteins in Alzheimer’s disease brains (2007) (34)
- Ultrastructural analyses of β-amyloid in the aged dog brain: Neuronal β-amyloid is localized to the plasma membrane (2000) (34)
- Immunocytochemical localization of serotonin in the rat dentate gyrus following raphe transplants (1986) (33)
- Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. (2001) (33)
- Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection (1990) (33)
- The progression of beta-amyloid deposition in the frontal cortex of the aged canine. (1997) (33)
- Increased density of excitatory amino acid transport sites in the hippocampal formation following an entorhinal lesion (1991) (33)
- Acidic amino acid antagonists of lateral perforant path synaptic transmission: agonist—antagonist interactions in the dentate gyrus (1982) (33)
- BioVision: An application for the automated image analysis of histological sections (2006) (32)
- Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study (1996) (32)
- Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease. (1994) (32)
- Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks (2004) (32)
- Lysosomal enzyme changes in young and aged control and entorhinal-lesioned rats (1983) (32)
- Identification of cell types in rat hippocampal slices maintained in organotypic cultures. (1982) (31)
- External force-assisted cell positioning inside microfluidic devices (2007) (31)
- The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer's Disease Pathology (1991) (31)
- Parallel Compensatory and Pathological Events Associated with Tau Pathology in Middle Aged Individuals with Down Syndrome (2003) (31)
- Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons. (2012) (31)
- Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates (1993) (30)
- Factors affecting survival and outgrowth from transplants of entorhinal cortex (1987) (30)
- Serologic specificities of brain subcellular organelles. I. Antisera to synaptosomal fractions. (1972) (30)
- Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells. (1999) (30)
- Healthy brain aging: A meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging (2008) (29)
- IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking (2017) (29)
- Factors specifying the development of synapse number in the rat dentate gyrus: effects of partial target loss (1980) (29)
- Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes. (1994) (29)
- Anatomical Organization of NMDA, Kainate and Quisqualate Receptors (1986) (29)
- Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes. (1994) (29)
- Adrenal hormone effects on hippocampal excitatory amino acid binding (1992) (29)
- Multiple Excitatory Amino Acid Receptor Regulation of Intracellular Ca2+ Implications for Aging and Alzheimer's Disease (1989) (28)
- Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus. (1974) (28)
- miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease (2020) (28)
- Enhanced stimulus-secretion coupling from brains of aged mice (1977) (28)
- Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise (2016) (27)
- Molecular markers of reactive plasticity. (1990) (27)
- Stimulation-dependent depression of readily releasable neurotransmitter pools in brain (1976) (27)
- Metabotropic Glutamate Receptor Agonists Potentiate Cyclic AMP Formation Induced by Forskolin or β‐Adrenergic Receptor Activation in Cerebral Cortical Astrocytes in Culture (1998) (27)
- Isolation, morphology, and protein and glycoprotein composition of synaptic junctional fractions from the brain of lower vertebrates: antigen PSD-95 as a junctional marker (1982) (27)
- Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. III. Competitive interactions (1982) (26)
- Axonal transport and axon sprouting in the adult rat dentate gyrus: An autoradiographic study (1980) (26)
- Excitatory Amino Acid Transmission in Health and Disease (2005) (26)
- A l-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes (1987) (25)
- Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs (2011) (25)
- Ultrastructural evidence for bouton proliferation in the partially deafferented dentate gyrus of the adult rat (1977) (25)
- Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device. (2007) (25)
- Nutritional management of brain aging in dogs. (2005) (24)
- Neonatal septal implants: Development of afferent lamination in the rat dentate gyrus (1980) (24)
- Color image analysis in neuroanatomical research: Application to senile plaque subtype quantification in Alzheimer's disease (1995) (24)
- L-glutamate and l-aspartate bind to separate sites in rat brain synaptic membranes (1981) (24)
- Invertebrate Learning and Memory (1999) (24)
- Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion (1980) (24)
- Short-term supplementation with acetyl-l-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles (2009) (24)
- Cations differentially affect subpopulations ofl-glutamate receptors in rat synaptic plasma membranes (1985) (24)
- N-methyl-d-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis andPapio papio) (1989) (24)
- Initiation and propagation of molecular cascades in human brain aging: Insight from the canine model to promote successful aging (2000) (24)
- Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease (2013) (24)
- Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. (1995) (24)
- Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines (2012) (24)
- Life span changes in the verbal categorization of odors. (1993) (24)
- Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging - eScholarship (2004) (23)
- Analysis of short-term plasticity at the perforant path-granule cell synapse (1979) (23)
- Long-term potentiation of excitatory and slow inhibitory synaptic potentials in the hippocampal-septal projection of the rat (1991) (23)
- Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta (2010) (23)
- Interleukin-1β interferes with signal transduction induced by neurotrophin-3 in cortical neurons (2008) (23)
- Postnatal development of the serotonin innervation of the hippocampus and dentate gyrus following raphe implants (1984) (23)
- Basic Fibroblast Growth Factor in the Mature Brain and Its Possible Role in Alzheimer's Disease (1991) (22)
- An experimental test of diaschisis. (1976) (22)
- 1‐Aminocyclopentane‐trans‐1,3‐Dicarboxylic Acid Induces Glutamine Synthetase Activity in Cultured Astrocytes (1992) (22)
- Stimulation of phosphoinositide hydrolysis by trans-(±)-ACPD is greatly enhanced when astrocytes are cultured in a serum-free defined medium (1993) (22)
- Alterations in [3H]kainate and N-methyl-d-aspartate-sensitive l-[3H]-glutamate binding in the rat hippocampal formation following fimbria-fornix lesions (1992) (22)
- Ionic regulation of glutamate binding sites. (1984) (22)
- β-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome (2002) (22)
- Regional distribution and ionic requirement of Cl−/Ca2+-activated and Cl−/Ca2+-independent glutamate receptors in rat brain (1983) (22)
- Learning deficits in rats with early neurotoxic lesions to the globus pallidus, substantia nigra, median raphe or pontine reticular formation (1986) (22)
- Analysis of brain injury following intrahippocampal administration of β-amyloid in streptozotocin-treated rats (1994) (22)
- Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices (1986) (22)
- Insoluble Proteins of the Synaptic Plasma Membrane (1970) (22)
- Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline (2019) (22)
- The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. (1999) (22)
- Regional distribution of [3H]kainic acid after intraventricular injection. (1980) (21)
- Turnover of brain postsynaptic densities after selective deafferentation: detection by means of an antibody to antigen PSD-95 (1982) (21)
- The Brain's Microenvironment, Early Functional Loss, and the Conversion to Alzheimer's Disease (2000) (21)
- Apoptosis in Alzheimer’s Disease (1998) (20)
- The β‐Amyloid Peptide, Peptide Self‐Assembly, and the Emergence of Biological Activities (1997) (20)
- Regional Distribution of α‐[3H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid Binding Sites in Rat Brain: Effect of Chemical Modification of SH– Groups in Tissue Sections (1990) (20)
- Excitatory Amino Acids and Hepatic Encephalopathy (1989) (20)
- L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices. (1993) (20)
- Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain (2012) (20)
- Plasticity in Alzheimer's disease: Too much or not enough? (1991) (20)
- Identification of neuronal plasma membrane microdomains that colocalize β-amyloid and presenilin: implications for β-amyloid precursor protein processing (2003) (20)
- Immunization with fibrillar Aβ1–42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Aβ (2006) (20)
- Effects of acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path (2004) (20)
- Stimulus secretion coupling in vitro: a rapid perfusion apparatus for monitoring efflux of transmitter substances from tissue samples. (1975) (20)
- Spatial patterns of mammalian brain aging: Distribution of cathepsin D–immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease (2003) (19)
- Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers (2012) (19)
- Electrophysiological analysis of the projection from the contralateral entorhinal cortex to the dentate gyrus in normal rats (1976) (19)
- Neurotrophic activity in the central and peripheral nervous systems of the cat. Effects of injury (1986) (19)
- Structure-activity relationships of l-glutamate receptor ligands: Role of the ω-acidic terminal (1982) (19)
- Preserved cerebellar tyrosine hydroxylase-immunoreactive neuronal fibers in a behaviorally aggressive subgroup of Alzheimer's disease patients (1998) (19)
- Membrane linked proteins at CNS synapses (1977) (19)
- β-Amyloid Increases Enzyme Activity and Protein Levels of Glutamine Synthetase in Cultured Astrocytes (1996) (19)
- Cross-linking of NCAM receptors on neurons induces programmed cell death (1998) (18)
- Synapse repair in the hippocampus: the effects of aging. (1983) (18)
- Short-Term Improvement on a Visual-Spatial Task After Music Listening in Alzheimer's Disease (2002) (18)
- Transplantation of septal neurons maintained in long-term culture (1986) (18)
- Calcium-dependent release of (14C)GABA from vinblastine and colchicine treated synaptosomes. (1974) (17)
- Enhanced vulnerability to apoptotic cell death in sporadic Alzheimer's disease (1998) (17)
- IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation (2018) (17)
- The influence of the carboxyl terminus of the Alzheimer Aβ peptide on its conformation, aggregation, and neurotoxic properties (2002) (17)
- Synaptic cleft glycoproteins contain homologous amino acid sequences. (1982) (16)
- Gene expression of Alzheimer‐associated presenilin‐2 in the frontal cortex of Alzheimer and aged control brain (1996) (16)
- Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models (2019) (16)
- Oligodendrocyte degeneration in AD (2004) (16)
- Entorhinal transplants and spatial memory abilities in rats (1987) (16)
- Bcl-2 family protein behavior in frontotemporal dementia implies vascular involvement (2001) (16)
- A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap (2013) (16)
- Enhancing the self-repairing potential of the CNS after injury. (1984) (15)
- The role of trophic factors in behavioral recovery and integration of transplants. (1988) (15)
- Melatonin treatment in old mice enables a more youthful response to LPS in the brain (2007) (15)
- Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons. (2007) (15)
- Increased spectrin proteolysis in the brindled mouse brain (1990) (15)
- Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic devices. (2007) (15)
- The Critical Afferent Theory: A Mechanism to Account for Septohippocampal Development and Plasticity (1981) (15)
- Learning and Memory (1999) (15)
- L-glutamate receptor populations in synaptic membranes: effects of ions and pharmacological characteristics. (1983) (14)
- Hippocampal but not astrocyte transplants enhance recovery on a forced choice alternation task after kainate lesions (1988) (14)
- Interactions between afferents to the dentate gyrus after entorhinal lesion during development: long-term regulation of choline acetyl-transferase activity (1978) (14)
- Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane. (2000) (14)
- Plasticity, pathology, and Alzheimer's disease (1989) (14)
- ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN (1976) (14)
- Regulatory Mechanisms of Synaptic Transmission (1981) (14)
- Synapse Formation and Plasticity in the Developing Dentate Gyrus (1978) (14)
- Principles for the Optimization of Centrifugation Conditions for Fractionation of Brain Tissue (1972) (14)
- Potentiation of excitatory synaptic transmission in the normal and in the reinnervated dentate gyrus of the rat (1976) (14)
- Subpopulations of dystrophic neuritis in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics (1994) (13)
- Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing. (2003) (13)
- Magnetic resonance imaging relaxation times and gadolinium-DTPA relaxivity values in human cerebrospinal fluid. (1998) (13)
- Adjuvant-dependent modulation of T h 1 and T h 2 responses to immunization with b-amyloid (2003) (13)
- Stimulus-secretion coupling processes in brain: Dependence upon extracellular calcium concentration (1979) (13)
- Lack of correlation between cortical levels of choline acetyltransferase and learning scores in rats with globus pallidus lesions (1986) (13)
- The beta-amyloid peptide, peptide self-assembly, and the emergence of biological activities. A new principle in peptide function and the induction of neuropathology. (1997) (13)
- Plasticity and growth factors in injury response (1998) (13)
- Stimulation-dependent depression of neurotransmitter release in brain: [Ca2+]0 dependence (1978) (12)
- Dietary and Behavioral Interventions Protect against Age Related Activation of Caspase Cascades in the Canine Brain (2011) (12)
- The effect of entorhinal cortical ablation on the distribution of muscarinic cholinergic receptors in the rat hippocampus (1982) (12)
- Canine cognition, aging and neuropathology (2000) (12)
- Specificity of Termination Fields Formed in the Developing Hippocampus by Fibers from Transplants (1984) (12)
- Adenosine, l-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: interstimulus interval-dependent pharmacology (2004) (12)
- Twelve – Synaptic Plasticity, Neurotrophic Factors, and Transplantation in the Aged Brain (1990) (12)
- Increased sensitivity to adenosine in the rat dentate gyrus molecular layer two weeks after partial entorhinal lesions (1993) (12)
- Histochemical detection of orthograde degeneration in the central nervous system of the rat. (1973) (11)
- Agonists selective for phosphoinositide-coupled receptors sensitize neurons to depolarization by l-2-amino-4-phosphonobutanoic acid (l-AP4) (1991) (11)
- Lesion-induced plasticity of high affinity choline uptake in the developing rat fascia dentata (1979) (11)
- Musashi1 antigen expression in human fetal germinal matrix development (2006) (11)
- Adaptive versus pathological plasticity. Possible contributions to age-related dementia. (1993) (11)
- Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus (2019) (11)
- A dual marking technique for microelectrode tracks and localization recording sites. (1975) (11)
- Survival at low and growth of hippocampal neurons in defined medium density : advantages of a sandwich culture technique or low oxygen (2002) (11)
- Amyloid deposition in cerebrovascular angiopathy. (1997) (10)
- Excitotoxic amino acid receptors in human complex partial epilepsy. (1990) (10)
- The coulometric titration of weak acids in non-aqueous media (1965) (10)
- The binding of diphenylhydantoin to brain and subcellular fractions. (1971) (10)
- Chronic immobilization stress differentially affects the expression of BDNF mRNA and protein in the mouse hippocampus (2004) (10)
- Normal and Pathological Aging: From Animals to Humans (2009) (10)
- Specific binding of kainic acid to purified subcellular fractions from rat brain (1980) (10)
- Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine (2016) (10)
- Response latency in Canis familiaris: mental ability or mental strategy? (2003) (10)
- A simple, objective method to measure the activity of factors that promote neuronal survival (1985) (9)
- Report of Alzheimer's disease working group A (1994) (9)
- Lesion-induced vascular changes in the dentate gyrus following removal of the entorhinal cortex in adult rats (1978) (9)
- Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. (2006) (9)
- Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity (2019) (9)
- Glutamate secretion and NAD(P)H levels during calcium-dependent depolarization of slices of the dentate gyrus (1978) (9)
- Induction of extensive fimbrial branching in the adult rat brain (1978) (9)
- Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease. (1990) (9)
- The distribution of [3H]kainate binding sites in primate hippocampus is similar to the distribution of both Ca2+-sensitive and Ca2+-insensitive [3H]kainate binding sites in rat hippocampus (1986) (8)
- Deposition of phosphorylated amyloid‐β in brains of aged nonhuman primates and canines (2018) (8)
- N‐methyl‐D‐aspartate receptors, synaptic plasticity, and Alzheimer's disease (1989) (8)
- Hydrocortison administration retards axon sprouting in the rat dentate gyrus. (1980) (7)
- Brainstem and cortical Lewy bodies in patients presenting clinically with Alzheimer's disease. (2002) (7)
- Lesion-induced synaptogenesis in brain: a study of dynamic changes in neuronal membrane specializations. (1976) (7)
- What are the earlier life contributions to reserve and resilience? (2019) (7)
- N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio). (1989) (7)
- Analysis of myelin-synaptosomal interactions in sucrose and Ficoll-sucrose gradients. (1972) (6)
- Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex (1991) (6)
- Axon Sprouting and Regeneration (1999) (6)
- Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro. (1995) (6)
- Regulation of acetylcholine muscarinic receptors by embryonic septal grafts showing cholinergic innervation of host hippocampus. (1988) (6)
- Receptor‐coupled phospholipase C and adenylyl cyclase function with different calcium pools in astrocytes (1998) (5)
- NEUROTRANSMISSIO N: NMDA Receptors and Hebb- Type (1988) (5)
- Cell death and survival (2004) (5)
- Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders (2019) (5)
- Long-term survival of neural transplants to senescence in rats (1990) (5)
- Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS‐Cog‐Exec (2020) (5)
- Relative potency of analogues of excitatory amino acids on hippocampal CA1 neurons (1983) (5)
- Lesion-induced alterations of lectin binding sites in the rat dentate gyrus (1981) (5)
- Semantic biological image management and analysis (2003) (5)
- Pattern separation and goal-directed behavior in the aged canine (2017) (5)
- Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors (1990) (5)
- Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines (2008) (4)
- Optimal concentration of iodonitrotetrazolium for the isolation of junctional fractions from rat brain (1981) (4)
- Cellular Signaling Pathways in Neuronal Apoptosis (2000) (4)
- BDNF-dependent synaptic plasticity is suppressed by IL-1 β via p38 MAPK (2013) (4)
- The β-Amyloid Model of Alzheimer’s Disease (1997) (4)
- Synaptic Reorganization in the Hippocampus: An Electrophysiological Analysis (1993) (4)
- Caspase-3 activation as a bifurcation point between plasticity and cell death (2012) (4)
- Subpopulations of dystrophic neurites [correction of neuritis] in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics. (1994) (4)
- REACTIVE SYNAPTOGENESIS IN THE ADULT CNS (1983) (4)
- Corrigendum: Exercise builds brain health: key roles of growth factor cascades and inflammation Trends in Neurosciences 30 (2007) 9, 464–472 (2007) (4)
- EXERT: A PHASE 3 MULTI-SITE RANDOMIZED CONTROLLED TRIAL OF AEROBIC EXERCISE IN MCI — STUDY DESIGN AND METHODS (2017) (4)
- Gradient design to optimize rate zonal separations. (1973) (4)
- Clinical trials: new opportunities. (2012) (4)
- The nature of increased histochemical deposition of INT formazan in fields of degenerating synaptic terminals. (1973) (4)
- An object relational approach to biomedical database (2000) (4)
- The β-Amyloid Model of Alzheimer's Disease:Conformation Change, Receptor Cross-Linking, the Initiation of Apoptosis (1996) (4)
- Role of Excitatory Amino Acids in the Development of Cerebellar Granule Neurones (1988) (4)
- Metabotropic glutamate receptors in cerebral cortical astrocytes: pharmacological properties of mGluR5 and interaction between PLC-and adenylate cyclase (AC)-coupled transduction systems (1996) (4)
- "Estrogen replacement therapy for treatment of mild to moderate disease: A randomized controlled trial": Errata. (2000) (4)
- Differences in alkaline earth stimulation of neurotransmitter release from isolated brain synaptosomes (2004) (4)
- Effects of entorhinal lesions on trophic activities present in rat entorhinal cortex and hippocampus as studied using primary cultures of entorhinal and septal tissues (1987) (4)
- A machine vision system for the automated classification and counting of neurons in 3-D brain tissue samples (1996) (3)
- On the road towards the global analysis of human synapses (2017) (3)
- Behavioral Neuroscience: An Introduction (2014) (3)
- Sleep and Activity Rhythms (1980) (3)
- PET studies of hippocampal metabolism in patients with Alzheimer's disease during an olfactory memory task (1989) (3)
- 3rd International Congress on Neurology and Epidemiology. Abu Dhabi, UAE, November 21–23, 2013: Abstracts (2013) (3)
- Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites. (2019) (3)
- Recruitment for a multi‐site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial (2020) (3)
- Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer's Disease (2000) (3)
- Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. (1988) (3)
- Stimulus-coupled secretion of gamma-aminobutyric acid from rat brain synaptosomes. (1973) (3)
- Synaptic Plasticity as a Model for Learning and Memory Research (1999) (3)
- Canine cognition, aging and neuropathology. Introduction. (2000) (3)
- Arrangement of the Acetylcholine Receptor Subunits in the Resting and Desensitized States , Determined by Cryoelectron Microscopy of Crystallized Torpedo Postsynaptic Membranes (2002) (3)
- Exercise and Cognitive Function: Neurobiological Mechanisms (2013) (3)
- Recruitment of a multi‐site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial (2021) (3)
- Brain tissue transplantation research. (1984) (2)
- Axon Sprouting and Reactive Synaptogenesis (1999) (2)
- Apoptosis and Alzheimer’s Disease: A Self-Assembly and the Initiation of Apoptosis by Plasma Membrane Receptor Cross-Linking (1997) (2)
- Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner (2021) (2)
- Hippocampal Plasticity and Excitatory Neurotransmitters (1982) (2)
- Synaptic Plasticity and Aging (1990) (2)
- Long-term support by injured brain extract of a subpopulation of ciliary ganglion neurons purified by differential adhesion (1987) (2)
- Acidic Amino Acids as Excitatory Transmitters (1981) (2)
- Parallel/distributed simulation with the COMPOSE object-relational database (1998) (2)
- The Living Brain and Alzheimer’s Disease (2004) (2)
- Synaptic Plasticity vs Pathology in Alzheimer’s Disease: Implications for Transplantation (1989) (2)
- B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation (1991) (2)
- Metabotropic Glutamate Receptors (2005) (2)
- Analytical zonal centrifugation of synaptosomes and mitochondria from rat brain homogenates. (1973) (2)
- Human brain tumor cyst fluid is mitogenic for primary astrocytes in culture. (1993) (2)
- Connections, Cognition and Alzheimer’s Disease (1997) (1)
- Early bioenergetic and autophagy impairments at the Parkinson's disease synapse. (2022) (1)
- Technique and instrumentation in physiological psychology. (1969) (1)
- AMultiancestral Genome-Wide Exome Array Study of Alzheimer Disease , Frontotemporal Dementia , and Progressive Supranuclear Palsy (2015) (1)
- Hearing, Tasting and Smelling, and Feeling (1980) (1)
- Structure--activity relationships of L-glutamate receptor ligands: role of the omega-acidic terminal. (1982) (1)
- Studies of Learning and Memory in Vertebrates (1999) (1)
- Glial uptake of glutamate an immunohistochemical study in the hippocampal slice (1987) (1)
- Serologic Specificities of Brain Subcellular Organelles (1972) (1)
- Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study (2012) (1)
- MRI QUANTIFICATION. REPLY (1991) (1)
- Subject Index Vol. 17, 2004 (2004) (1)
- A DECREASE IN THE NUMBER OF GABAERGIC SOMATA OCCURS IN PRESEIZING MONKEYS WITH ALUMINA GEL GRANULOMA - A CAUSAL ROLE OF GABA IN FOCAL EPILEPSY (1987) (1)
- The reduction of neurotrophin-3 induced signal transduction by interleukin-1β in cultured cortical neurons: A model of Alzheimer's disease (2010) (1)
- A novel use of color computer vision methods for the quantification of neurons in 3-D brain tissue samples (1998) (1)
- Molecular Organization of Glutamate Receptors in the Postsynaptic Density (2005) (1)
- 423 β-Amyloid neurotoxicity in vitro: Examination of potential contributions by oxidative pathways (1996) (1)
- β‐Amyloid Toxicity: Diverse Biological Activities Drive Multiple Cellular Mechanisms (2002) (1)
- Maintenance and Regulation in Brain of Neurotransmission, Trophic Factors, and Immune Responses (2011) (1)
- Use of Voxel-based Morphometry Techniques to Assess the Benefits of an Antioxidant Diet in Preventing Cortical Atrophy in a Dog Model of Brain Aging (2005) (1)
- Topline Results of EXERT: Can Exercise Slow Cognitive Decline in MCI? (2022) (1)
- Remaining Questions and Future Directions (1999) (1)
- Glutamate and Glutamate Receptors in Neurological Diseases (2005) (1)
- Exercise and prevention of dementia (2010) (1)
- C1Q and inflammation in Down syndrome pathogenesis (2000) (1)
- APOPTOSIS IN ALZHEIMER'S DISEASE Inductive Agents and Antioxidant Protective Factors (1998) (1)
- Exercise in Neurodegenerative Disease and Stroke (2009) (1)
- Apolipoprotein E and Alzheimer’s Disease (1996) (0)
- Evaluation of the Strength of Evidence for Supplementation Use for Healthy Cognitive Function (2003) (0)
- Adaptive and failed CNS neuroplasticity: A tribute to Carl Cotman. (2003) (0)
- Excitatory Amino Acid Synapses: Studies of Normal and Reorganized Pathways (1988) (0)
- Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs (2011) (0)
- Neural stem cells rescue deficits in Alzheimer's transgenic mice (2011) (0)
- Omega-3 fatty acid deficit in Alzheimer's disease (2009) (0)
- JAMA Neurology Peer Reviewers in 2017. (2018) (0)
- Retention of Function in the Aged Brain:The Pivotal Role of β-Amyloid (1995) (0)
- EXERT: Impact of COVID‐19 on retention and intervention delivery of a large multisite exercise trial in adults with MCI (2021) (0)
- In Memoriam: Henry R. Mahler 1921‐1983 (1984) (0)
- P3-135 Interleukin-1β impairs activity-dependent camp-response element binding protein signaling of neurotrophin-3 in cerebral cortical neurons (2004) (0)
- S1-01-04: What goes wrong with the brain during aging (2007) (0)
- Studies of Physical Activity Intervention in Transgenic Models of Alzheimer's: 464 (2008) (0)
- Letter from Carl W. Cotman and Earl Usdin to Marshall W. Nirenberg (1983) (0)
- Trafficking of Glutamate Receptors (2005) (0)
- 5 – Synaptic Transmission (1980) (0)
- P1-054 AN EXPLORATION OFA FUNCTIONAL UNIT OF DNA METHYLATION IN THE AGING BRAIN (2013) (0)
- Multiple excitatory and amino acid receptor regulation of intracellular calcium implications for aging and alzheimers disease (1989) (0)
- an NMDA receivers (1987) (0)
- The international neuropeptide society (1994) (0)
- An object relational database for brain aging research (1998) (0)
- Author's response to commentaries (1996) (0)
- TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse (2018) (0)
- IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking (2017) (0)
- Contents Vol. 17, 2004 (2004) (0)
- UC Irvine UC Irvine Previously Published Works Title An experimental test of diaschisis (2004) (0)
- BDNF and Alzheimer's Disease—What's the Connection? (2003) (0)
- Thirst and Hunger (1980) (0)
- Behavioral neuroscience : an instructor's guide (1979) (0)
- Brain and Spinal Cord Transplants (1999) (0)
- FKBP51 Accelerates Alzheimer's Disease Pathogenesis (2013) (0)
- 15-Deoxy-Ä-prostaglandin J2, a speci®c ligand for peroxisome proliferator-activated receptor-ã, induces neuronal apoptosis (0)
- Complex Learning and Memory (1980) (0)
- Aerobic exercise effects on the peripheral plasma lipidome in mild cognitive impairment: The influence of prediabetes (2020) (0)
- JAMA Neurology Peer Reviewers in 2017. (2018) (0)
- Editors List From 1976 To 2009 (2009) (0)
- Signal Transduction, Kinase and Phosphatases (2003) (0)
- Erratum to “Spatial learning is delayed and brain-derived neurotrophic factor mRNA expression inhibited by administration of MK-801 in rats” [Neurosci. Lett. 353 (2003) 95–98] (2004) (0)
- Excitatory Amino Acid Transmission and Synaptic Plasticity (2005) (0)
- Aβ OLIGOMERS IMPAIR PLASTICITY BY DYSREGULATING MIR-181A IN PRIMARY HIPPOCAMPAL CULTURES (2018) (0)
- Elementary Learning and Behavioral Plasticity (1980) (0)
- Cell therapy plus voluntary running rescues memory dysfunction in a rodent model of brain ageing (2011) (0)
- MRI quantification [7] (1991) (0)
- Contents Vol. 41, 2013 (2013) (0)
- 9 – Synaptic Growth as a Plasticity Mechanism in the Brain (1980) (0)
- O1-01-04 Inflammatory cell infiltrates are commonly associated with brain vasculature and cerebral amyloid angiopathy in Alzheimer’s disease (2006) (0)
- In Reply (1997) (0)
- Presenilins and Alzheimer’s Disease (1998) (0)
- What Does the Nervous System Do (1980) (0)
- 722 Multiple neuropathological variables are correlated with the level of cognitive impairment in Alzheimer's disease (1996) (0)
- Chapter 21 - Trophic Factors and Cell Adhesion Molecules Can Drive Dysfunctional Plasticity and Senile Plaque Formation in Alzheimer's Disease through a Breakdown in Spatial and Temporal Regulation (1999) (0)
- Overview and Perspective (2005) (0)
- Research report Heparan sulfate and chondroitin sulfate glycosaminoglycan /3-amyloid(25-35) neurodegeneration in cultured hippocampal neurons (1995) (0)
- Internal States of the Body: Autonomic, Neuroendocrine and Pain Functions (1980) (0)
- Molecular Composition of Synaptic Junctions and Post-Synaptic Densities: A Functional Perspective (1982) (0)
- Short communication E increases the vulnerability of rat hippocampal neurons to kainate lesion (2003) (0)
- 5. Molecular dating of senile plaques in the brains of individuals with Down syndrome. (2000) (0)
- Effects of acetyl-L-carnitine and Lipoic Acid supplementation on cognition in aged beagles (2010) (0)
- Overexpression of Bcl-2 in APP transgenic mice reduces amyloid pathology (2010) (0)
- Characteristics of Receptors for Excitatory Neurotransmitters (1984) (0)
- Pilot trial of buddy-assisted exercise in people with mild cognitive impairment (2013) (0)
- Volume contents and author index (1984) (0)
- Apoptosis is induced by fB-amyloid in cultured central nervous system neurons ( Alzheiner / prgrammed cell death / neurodegeneration ) (2005) (0)
- Decreased hippocampal metabolic rate in patients with SDAT assessed by positron emission tomography during olfactory memory task (1990) (0)
- Effect of an Antioxidant-Diet and Cognitive Enrichment on Age-Dependent Cognitive Dysfunction in Dogs (2005) (0)
- Application of color machine vision methodologies to the quantification of cell populations in 3-D brain tissue samples (1998) (0)
- Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress (2022) (0)
- In Reply: Non-Insulin-Dependent Diabetes Mellitus and Alzheimer's Disease (1997) (0)
- Subject Index Vol. 54+55, 1990 (1990) (0)
- Integration: Putting It All Together (1980) (0)
- Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity (2020) (0)
- Active rule processing in the BioCompose database (1998) (0)
- Title An amyloid β 42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer ' s disease Permalink (2012) (0)
- Acknowledgements to referees (2010) (0)
- Title: Frontal Lobe Volume, Function, and A (cid:1) Pathology in a Canine Model of Aging Abbreviated Title: Frontal Lobe Volume and Aging in the Beagle (2005) (0)
- INHIBITION OF ACTIVITY-DEPENDENT PROTEIN SYNTHESIS BY IL-1β IN HIPPOCAMPAL DENDRITES (2019) (0)
- P3-066 Changes in frontal lobe volume, executive function, and amyloid load in a canine model of aging (2004) (0)
- Despite degeneration of astrocytes, the blood-brain barrier is minimally compromised in frontotemporal dementia (1999) (0)
- Signaling Mechanisms that Mediate Aβ Induced Neuronal Dysfunction (2007) (0)
- Neutrophin-trafficking deficits are mediated by impaired ubiquitin recycling in Alzheimer's disease (2012) (0)
- Nutritional Antioxidant Enrichment and Improved Cognitive Function in Canines (2005) (0)
- Apoptotic Insults Suppress Markers of Neuronal Plasticity (2000) (0)
- Acknowledgement to reviewers (2004) (0)
- Exercise Alters Immune Response in Hippocampus of Transgenic Alzheimer Mouse Model and Improves Reference Memory: 1872 (2006) (0)
- Use of Neuroimaging to Examine Genotype and Exercise Interactions on Cognitive Function: 463 (2008) (0)
- 17 – Behavioral Disorders (1980) (0)
- Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease (2023) (0)
- Title BDNF-dependent synaptic plasticity is suppressed by IL-1 β via p 38 MAPK Permalink (2013) (0)
- Delta Glutamate Receptors (2005) (0)
- Multidisciplinary Studies on Excitatory Amino Acids as Transmitters in the Brain. (1985) (0)
- The Hsp90 co-chaperone FKBP51 produces neurotoxic tau oligomers: Implication for aging and Alzheimer's disease (2013) (0)
- Effect of antibrain synaptosomal fraction serum and complement on evoked potentials and impedance (1972) (0)
- Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes (2012) (0)
- In vivo cytoprotective acting neurotropic alcohols. (1989) (0)
- Editorial and Overview (1984) (0)
- Alzheimer research forum live discussion: Brain derived neurotrophic factor and Alzheimer's disease - What is the connection? (2005) (0)
- Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise (2016) (0)
- Decreased levels of soluble amyloid a 8-protein precursor in cerebrospinal fluid of live Alzheimer disease patients ( enzyme-linked immunosorbent assay / clinical dlagnoss / protease nexin 2 ) (0)
- Developing Topics e65 P4-440 DECLINE IN TAU LEVELS FROM ANTISENSE OLIGO TREATMENT: A POTENTIAL CURATIVE MECHANISM FOR ALZHEIMER’S DISEASE (2011) (0)
- Basic Principles of Neuronal Signaling (1980) (0)
- 732 Ref-1 immunoreactivity in Alzheimer's disease (1996) (0)
- The Development, Remodeling and Aging of Neuronal Circuitry (1980) (0)
- Ionotropic Glutamate Receptors: General Characteristics (2005) (0)
- Studies of Learning and Memory in Humans (1999) (0)
- An Object Relational Approach to Biomedical Databases. (2000) (0)
- Keynote - Exercise Regulates Synaptic Plasticity and Delays Age-Related Brain Pathology and Dysfunction: 461 (2008) (0)
- Rationale, design and preliminary baseline data of the ADEX study: The effect of physical exercise in Alzheimer's disease (2013) (0)
- Learning differentially increases the synaptic levels of AMPA receptor subunits (GluA1‐GluA4) in the rodent hippocampus: a single‐synapse approach (2022) (0)
- MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS (2019) (0)
- P3-312 Expression of certain activity-dependent genes, implicated in neuronal plasticity, is impaired in the hippocampus of amyloid precursor protein transgenic mice (2004) (0)
- An overview and perspective on the potential relevance of neuronal growth to the development of epilepsy and epilepsy-related disturbances. (1992) (0)
- β-amyloid: An inert deposit comes alive (2000) (0)
- An electromechanical pH stat providing bidirectional control (1964) (0)
- Imaging Techniques - A Vision into the Future?: 2140 9:05 AM - 9:35 AM (2005) (0)
- Dispositif microfluidique a compartiments multiples pour recherche neuroscientifique (2003) (0)
- DENSITIES: A FUNCTIONAL PERSPECTIVE (1982) (0)
- Synapses and Epigenetics in the Alzheimer ’ s Brain (2013) (0)
- RELATIONSHIPS BETWEEN INSOLUBLE PROTEINS IN MEMBRANE SUBCELLULAR FRACTIONS FROM RAT BRAIN (1969) (0)
- Why Am I What I Am (1980) (0)
- Organizing Principles of the Nervous System (1980) (0)
- Corrigendum to ‘Mild stress facilitates learning and exercise improves retention in aged mice’ [Experimental Gerontology 46/1 (2011) page 53–59] (2011) (0)
- IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation (2018) (0)
- Original Contribution Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction (2008) (0)
- Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with The (2020) (0)
- Impairment of Neurotrophin-3-Induced Phosphorylation of cAMP Response Element-Binding Protein Caused by Interleukin-1β in Cultured Cortical Neurons (2006) (0)
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