Carl Pabo
#32,905
Most Influential Person Now
Biologist; professor
Carl Pabo's AcademicInfluence.com Rankings
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Biology
Carl Pabo's Degrees
- PhD Biology Stanford University
- Masters Biology Stanford University
- Bachelors Biology Stanford University
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Why Is Carl Pabo Influential?
(Suggest an Edit or Addition)According to Wikipedia, Carl O. Pabo is a biophysicist. He is the founder and president of Humanity 2050, a nonprofit institute. Education B.S. from Yale, Molecular Biophysics and Biochemistry in 1974Ph.D. from Harvard, Biochemistry and Molecular Biology in 1980.
Carl Pabo's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cellular uptake of the tat protein from human immunodeficiency virus (1988) (2583)
- Transcription factors: structural families and principles of DNA recognition. (1992) (1416)
- Protein-DNA recognition. (1984) (1389)
- An improved zinc-finger nuclease architecture for highly specific genome editing (2007) (1033)
- DNA recognition by Cys2His2 zinc finger proteins. (2000) (959)
- Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions (1990) (891)
- Design and selection of novel Cys2His2 zinc finger proteins. (2001) (673)
- Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. (1993) (647)
- The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. (1993) (518)
- Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules (1994) (485)
- Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins (1999) (483)
- Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation (1994) (451)
- Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions (1991) (438)
- Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. (1994) (422)
- Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions. (1996) (413)
- The operator-binding domain of λ repressor: structure and DNA recognition (1982) (412)
- Tat protein from human immunodeficiency virus forms a metal-linked dimer. (1988) (410)
- A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions. (2000) (379)
- Homology among DNA-binding proteins suggests use of a conserved super-secondary structure (1982) (364)
- Crystal structure of a paired domain-DNA complex at 2.5 å resolution reveals structural basis for pax developmental mutations (1995) (344)
- Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. (1999) (305)
- Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. (1999) (283)
- Gene-Specific Targeting of H3K9 Methylation Is Sufficient for Initiating Repression In Vivo (2002) (272)
- Drug discovery with engineered zinc-finger proteins (2003) (254)
- Geometric analysis and comparison of protein-DNA interfaces: why is there no simple code for recognition? (2000) (240)
- Metal-dependent folding of a single zinc finger from transcription factor IIIA. (1987) (239)
- A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites (1997) (220)
- DNA recognition by β-sheets in the Arc represser–operator crystal structure (1994) (215)
- Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. (1998) (212)
- High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition. (1998) (206)
- DNA recognition by beta-sheets in the Arc repressor-operator crystal structure. (1994) (202)
- The lambda repressor contains two domains. (1979) (191)
- Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code. (1999) (182)
- DNA RECOGNITION BY Cys 2 His 2 ZINC FINGER PROTEINS (2000) (181)
- Molecular technology: Designing proteins and peptides (1983) (166)
- Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection (2003) (162)
- Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity (2003) (153)
- Structural studies of the engrailed homeodomain (1994) (145)
- Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes. (2001) (139)
- Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage. (1996) (139)
- Structure-based design of transcription factors. (1995) (138)
- Comparison of X-ray and NMR structures for the Antennapedia homeodomain–DNA complex (1998) (129)
- An engineered intersubunit disulfide enhances the stability and DNA binding of the N-terminal domain of lambda repressor. (1986) (125)
- Regulatory functions of the λ repressor reside in the amino-terminal domain (1979) (110)
- [76] Bacteriophage λ repressor and cro protein: Interactions with operator DNA (1980) (108)
- Engrailed homeodomain-DNA complex at 2.2 A resolution: a detailed view of the interface and comparison with other engrailed structures. (1998) (104)
- Identification of protein folds: Matching hydrophobicity patterns of sequence sets with solvent accessibility patterns of known structures (1990) (103)
- Distinctive DNA conformation with enlarged major groove is found in Zn-finger-DNA and other protein-DNA complexes. (1994) (102)
- Computer-aided model-building strategies for protein design. (1986) (99)
- Repressor and Cro Protein: Structure, Function, and Role in Lysogenization (1983) (98)
- The N-terminal arms of λ repressor wrap around the operator DNA (1982) (91)
- Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. (1999) (88)
- Dimerization of the tat protein from human immunodeficiency virus: a cysteine-rich peptide mimics the normal metal-linked dimer interface. (1988) (88)
- How the lambda repressor and cro work. (1980) (83)
- Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity. (1997) (83)
- Binding Studies with Mutants of Zif268 (1999) (83)
- Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition. (2001) (77)
- Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors. (2003) (76)
- Structure-based design of a dimeric zinc finger protein. (1998) (64)
- Combining structure-based design with phage display to create new Cys(2)His(2) zinc finger dimers. (2000) (61)
- Engineered Zinc Finger Proteins for Controlling Stem Cell Fate (2003) (59)
- A genetic switch in a bacterial virus. (1982) (57)
- Systematic variation in DNA length yields highly ordered repressor-operator cocrystals. (1985) (57)
- Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression. (1997) (54)
- Lambda repressor: a model system for understanding protein-DNA interactions and protein stability. (1990) (54)
- Dimerization of the operator binding domain of phage lambda repressor. (1987) (54)
- Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities. (1996) (50)
- Fingering too many proteins (1988) (46)
- Structure of a designed dimeric zinc finger protein bound to DNA. (2003) (44)
- Combining thermostable mutations increases the stability of λ repressor (1988) (40)
- Dimerization of zinc fingers mediated by peptides evolved in vitro from random sequences. (1999) (38)
- Constraints for zinc finger linker design as inferred from X-ray crystal structure of tandem Zif268-DNA complexes. (2003) (37)
- Exploring the role of glutamine 50 in the homeodomain-DNA interface: crystal structure of engrailed (Gln50 --> ala) complex at 2.0 A. (2000) (37)
- Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA (2001) (33)
- Bacteriophage lambda repressor and cro protein: interactions with operator DNA. (1980) (32)
- Analysis of homeodomain function by structure-based design of a transcription factor. (1995) (30)
- Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. (2004) (27)
- New generation databases for molecular biology (1987) (22)
- The N-terminal arms of lambda repressor wrap around the operator DNA. (1982) (16)
- Crystallization and preliminary X-ray diffraction studies of the engrailed homeodomain and of an engrailed homeodomain/DNA complex. (1990) (16)
- Cell Lines for Drug Discovery: Elevating Target-Protein Levels Using Engineered Transcription Factors (2004) (15)
- Regulatory functions of the lambda repressor reside in the amino-terminal domain. (1979) (14)
- The X repressor contains two domains ( scanning calorimetry / papain digestion / oligomerization / DNA binding ) (12)
- Systematic analysis of possible hydrogen bonds between amino acid side chains and B-form DNA. (1983) (8)
- Crystallization of the Arc repressor. (1985) (8)
- Crystallization and preliminary X-ray diffraction studies of a MATα2-DNA complex (1991) (8)
- Pharmacological analysis of CCK2 receptors up-regulated using engineered transcription factors (2005) (6)
- Combining thermostable mutations increases the stability of lambda repressor. (1988) (5)
- ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX (1998) (4)
- Specificity by design (2006) (2)
- 714. Structure-Based Engineering of the FokI DNA Cleavage Domain in the Context of a Chimeric Endonuclease: Towards Maximally Efficient |[ldquo]|Gene Editing|[rdquo]| Therapy (2004) (1)
- ENGRAILED HOMEODOMAIN DNA COMPLEX (1998) (1)
- STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (TATAZF;CLONE #6) (2001) (1)
- 325. Identification of Mechanistically Distinct Repression Domains at Endogenous Genes Using Engineered Zinc Finger Proteins (2004) (0)
- How the phage lambda repressor and cro work (1980) (0)
- Crystal Structure of tandem Zif268 molecules complexed to DNA (2003) (0)
- DSNR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GACC SITE) (1998) (0)
- Polyproteins zinc finger they are having improved linkers. (1999) (0)
- ENGRAILED HOMEODOMAIN Q50K VARIANT DNA COMPLEX (1998) (0)
- Methodes et compositions de dosage de piegeage par interaction (2001) (0)
- STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (CLONE #2) (2001) (0)
- A method for delivering molecules to eukaryotic cells (1990) (0)
- FIVE-FINGER GLI/DNA COMPLEX (1993) (0)
- CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT (1999) (0)
- Transcription Factors Glioblastoma Cells Using Engineered Zinc Finger Repression of Vascular Endothelial Growth Factor A in Updated (2003) (0)
- Co-crystallization of repressor and operator fragments from bacteriophage lambda (1981) (0)
- A method for transport of molecules in eukaryotic cells (1990) (0)
- 787. Engineered Fok I Heterodimers for Enhanced Zinc Finger Nuclease Specificity (2006) (0)
- 379. New Zinc Finger Protein Nuclease Architectures for More Efficient Gene Modification Therapies (2005) (0)
- ZIF268 ZINC FINGER-DNA COMPLEX (1997) (0)
- CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS (1999) (0)
- COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA (2001) (0)
- ENGRAILED HOMEODOMAIN Q50A VARIANT DNA COMPLEX (1998) (0)
- Computer-Aided Design of Thermostable Proteins. (1988) (0)
- Crystal Structure of a Zif23-GCN4 Chimera Bound to DNA (2003) (0)
- ZIF268 ZINC FINGER-DNA COMPLEX (GCAC SITE) (1998) (0)
- 51. A Novel Approach to Stem Cell Gene Therapy: Controlling Stem Cell ifferentiation with Engineered Zinc-Finger Protein Transcription Factors (2004) (0)
- Zif268 D20A Mutant Bound to WT DNA Site (2001) (0)
- CRYSTAL STRUCTURE OF HMG1 DOMAIN A BOUND TO A CISPLATIN-MODIFIED DNA DUPLEX (1999) (0)
- Zif268 D20A mutant bound to the GCT DNA site (2001) (0)
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