Carla Ghelardini

Carla Ghelardini's AcademicInfluence.com Rankings

Carla Ghelardini

Chemistry

#4024

World Rank

#5080

Historical Rank

Organic Chemistry

#644

World Rank

#738

Historical Rank

chemistry Degrees

Download Badge

Chemistry

Why Is Carla Ghelardini Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Carla Ghelardini's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Menthol: a natural analgesic compound (2002) (343)
Local anaesthetic activity of β-caryophyllene ☆ (2001) (245)
Local anaesthetic activity of the essential oil of Lavandula angustifolia. (1999) (200)
A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages. (2014) (159)
Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. (2007) (156)
Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. (2012) (154)
Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain. (2013) (153)
Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. (2000) (137)
Glial role in oxaliplatin-induced neuropathic pain (2014) (127)
Role of muscarinic receptor subtypes in central antinociception (1992) (122)
Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain (2017) (120)
Role of histamine in rodent antinociception (1994) (117)
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects. (2015) (116)
Analgesic effects of myrrh (1996) (116)
[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents. (2003) (108)
Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism (2013) (108)
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. (2002) (100)
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis. (2017) (98)
Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors (2016) (96)
Local anaesthetic activity of beta-caryophyllene. (2001) (95)
New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics. (2010) (90)
α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement (2014) (90)
The pharmacological basis of opioids. (2015) (89)
Oxaliplatin-induced oxidative stress in nervous system-derived cellular models: could it correlate with in vivo neuropathy? (2013) (86)
6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells. (2015) (81)
Local anaesthetic activity of monoterpenes and phenylpropanes of essential oils. (2001) (80)
Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients (2019) (79)
Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. (2016) (79)
Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels (2017) (78)
Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity (2015) (77)
Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes (2009) (77)
Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: Effects of selective activation (2014) (76)
Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat. (1997) (75)
Role of 5-HT4 receptors in the mouse passive avoidance test. (1998) (75)
CGP 35348, a new GABAB antagonist, prevents antinociception and muscle‐relaxant effect induced by baclofen (1991) (74)
Signaling pathway of morphine induced acute thermal hyperalgesia in mice (2006) (72)
Development and characterization of niosomal formulations of doxorubicin aimed at brain targeting. (2012) (71)
Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy? (2017) (70)
Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors. (2000) (69)
Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy (2018) (69)
Antinociception induced by systemic administration of local anaesthetics depends on a central cholinergic mechanism (1987) (67)
Oxaliplatin Neurotoxicity Involves Peroxisome Alterations. PPARγ Agonism as Preventive Pharmacological Approach (2014) (62)
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. (2007) (62)
The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress. (2016) (61)
Protective effect of acetyl‐l‐carnitine on the apoptotic pathway of peripheral neuropathy (2007) (61)
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity. (2013) (61)
Development and characterization of functionalized niosomes for brain targeting of dynorphin-B. (2014) (61)
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain (2013) (61)
Investigation into atropine‐induced antinociception (1990) (61)
Involvement of potassium channels in amitriptyline and clomipramine analgesia (2001) (59)
Local anaesthetic activity of (+)- and (-)-menthol. (2001) (59)
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes. (2008) (59)
Loss of muscarinic antinociception by antisense inhibition of M1 receptors (2000) (58)
Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation. (2012) (58)
Effect of potassium channel modulators in mouse forced swimming test (1999) (58)
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. (2016) (58)
Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats (2010) (57)
Caffeine induces central cholinergic analgesia (1997) (56)
Analgesic and Antineuropathic Drugs Acting Through Central Cholinergic Mechanisms (2011) (54)
The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment (2016) (54)
Therapeutic Effects of the Superoxide Dismutase Mimetic Compound MnIIMe2DO2A on Experimental Articular Pain in Rats (2013) (53)
Effect of glucoraphanin and sulforaphane against chemotherapy‐induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo (2018) (53)
Activation of JNK pathway in spinal astrocytes contributes to acute ultra–low-dose morphine thermal hyperalgesia (2015) (52)
Protective effect of alpha7 nAChR: Behavioural and morphological features on neuropathy (2010) (52)
Selenium and zinc: Two key players against cadmium-induced neuronal toxicity. (2018) (52)
St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. (2010) (52)
Influence of potassium channel modulators on cognitive processes in mice (1998) (51)
Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat (2009) (51)
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. (2017) (51)
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. (2007) (51)
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. (2017) (50)
Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling. (1998) (50)
Low dose native type II collagen prevents pain in a rat osteoarthritis model (2013) (49)
Neuroprotective effects of acetyl‐L‐carnitine on neuropathic pain and apoptosis: A role for the nicotinic receptor (2009) (49)
The Phospholipase C-IP3 Pathway is Involved in Muscarinic Antinociception (2003) (48)
Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1 (2015) (48)
Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test (2006) (47)
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy (2018) (46)
Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. (1996) (46)
Anticancer properties of erucin, an H2S‐releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC‐1) (2019) (46)
Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation (2015) (46)
Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anesthetic efficacy (2010) (45)
Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity. (2008) (45)
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles. (2018) (45)
Pleiotropic effect of histamine H4 receptor modulation in the central nervous system (2013) (45)
Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats (2002) (44)
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype (2004) (44)
Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier (2019) (44)
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. (2006) (44)
Investigation into the role of histamine receptors in rodent antinociception (1996) (43)
Salvianolic acid B and its liposomal formulations: anti-hyperalgesic activity in the treatment of neuropathic pain. (2011) (43)
The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1 (2020) (42)
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models (2010) (42)
Oxaliplatin-induced blood brain barrier loosening: a new point of view on chemotherapy-induced neurotoxicity (2018) (42)
Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions (2017) (42)
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation. (2010) (42)
A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury. (2009) (42)
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis. (2018) (41)
α2‐Agonists as analgesic agents (2009) (41)
Serotonergic modulation in neuropathy induced by oxaliplatin: effect on the 5HT2C receptor. (2014) (41)
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII. (2018) (41)
Erucin exhibits vasorelaxing effects and antihypertensive activity by H2S‐releasing properties (2019) (40)
Antihyperalgesic activity of verbascoside in two models of neuropathic pain (2011) (40)
Development and in vivo evaluation of an innovative "Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles" formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics. (2017) (40)
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds. (2011) (39)
Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo) (2016) (39)
Acetyl-l-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy (2010) (39)
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors. (2013) (38)
Central Cholinergic Challenging of Migraine by Testing Second‐Generation Anticholinesterase Drugs (2002) (38)
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties. (2011) (38)
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. (2018) (37)
M1 receptor activation is a requirement for arecoline analgesia. (2001) (37)
α2 Adrenoceptor: a Target for Neuropathic Pain Treatment. (2016) (36)
Supraspinal Gβγ‐dependent stimulation of PLCβ3 originating from G inhibitory protein‐μ opioid receptor‐coupling is necessary for morphine induced acute hyperalgesia (2009) (36)
Hypofunctionality of Gi Proteins as Aetiopathogenic Mechanism for Migraine and Cluster Headache (2001) (36)
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects. (2018) (35)
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway (2004) (35)
A gene‐specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant‐like effect in mice (2008) (35)
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. (2006) (35)
Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy. (2016) (35)
Role of potassium channels in the antinociception induced by agonists of α2‐adrenoceptors (1999) (35)
Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus. (2017) (35)
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. (2018) (34)
Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP). (2001) (33)
Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy. (2018) (33)
The neuropathy-protective agent acetyl-l-carnitine activates protein kinase C-γ and MAPKs in a rat model of neuropathic pain (2010) (32)
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy (2019) (32)
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity. (2000) (32)
Liposomal Formulation to Increase Stability and Prolong Antineuropathic Activity of Verbascoside (2016) (32)
Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: A step toward improving opioid pain therapy (2014) (32)
Delay of Morphine Tolerance by Palmitoylethanolamide (2015) (31)
Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. (2019) (31)
Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain. (2004) (31)
Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist (2020) (30)
Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia (2004) (30)
Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain (2018) (30)
Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities. (2002) (30)
Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception. (1996) (30)
Acute effect of Capparis spinosa root extracts on rat articular pain. (2016) (29)
The central cholinergic system has a role in the antinociception induced in rodents and guinea pigs by the antimigraine drug sumatriptan. (1996) (29)
PKC-mediated HuD-GAP43 pathway activation in a mouse model of antiretroviral painful neuropathy. (2014) (29)
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters. (1994) (29)
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies. (2012) (29)
5-HT1A Agonists Induce Central Cholinergic Antinociception (1997) (29)
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent. (2008) (29)
Endogenous morphine modulates acute thermonociception in mice (2002) (29)
In Vitro Evidence for the Use of Astragali Radix Extracts as Adjuvant against Oxaliplatin-Induced Neurotoxicity (2015) (29)
Pharmacological identification of SM-21, the novel σ2 antagonist (2000) (28)
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines. (2018) (28)
Desensitization of GABAB receptors and antagonism by CGP 35348, prevent bicuculline- and picrotoxin-induced antinociception (1992) (28)
Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. (2019) (28)
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. (2002) (27)
Effects of endogenous morphine deprivation on memory retention of passive avoidance learning in mice. (2004) (27)
Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the acetylcholine releaser PG-9. (1998) (27)
DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer (2002) (27)
Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation (2018) (27)
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents. (2000) (27)
Blockade of clomipramine and amitriptyline analgesia by an antisense oligonucleotide to mKv1.1, a mouse Shaker-like K+ channel. (1997) (27)
Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo (2008) (27)
An antisense oligonucleotide on the mouse Shaker-like potassium channel Kv1.1 gene prevents antinociception induced by morphine and baclofen. (1997) (26)
Methylamine and benzylamine induced hypophagia in mice: Modulation by semicarbazide‐sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels (2001) (26)
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity. (2003) (26)
Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis (2017) (26)
Oxidative, Metabolic, and Apoptotic Responses of Schwann Cells to High Glucose Levels (2015) (26)
Pain relieving and protective effects of Astragalus hydroalcoholic extract in rat arthritis models (2017) (26)
Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation. (2016) (26)
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation. (2013) (26)
Neurotransmitter role of endogenous morphine in CNS. (2005) (25)
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of St. John's Wort in mice (2010) (25)
Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors (2016) (25)
Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models. (2013) (25)
α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity (2015) (25)
Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin (2019) (25)
Antisense ‘knockdowns’ of M1 receptors induces transient anterograde amnesia in mice (1999) (25)
Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium (2019) (24)
Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor. (2013) (24)
Histamine H4 receptor agonist‐induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress (2017) (24)
Aminopyrrolic synthetic receptors for monosaccharides: a class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts. (2012) (24)
Acetyl-l-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception (2004) (24)
Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. (2018) (24)
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. (2004) (24)
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies. (2008) (24)
The RNA-binding protein HuD promotes spinal GAP43 overexpression in antiretroviral-induced neuropathy (2014) (24)
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-l-carnitine activity on depression (2011) (24)
Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10. (2021) (24)
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels. (2012) (23)
Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception (1997) (23)
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity. (2016) (23)
HuD-mediated distinct BDNF regulatory pathways promote regeneration after nerve injury (2017) (22)
Neuroprotective Activity of Thioctic Acid in Central Nervous System Lesions Consequent to Peripheral Nerve Injury (2013) (22)
Should Patients Receiving ACE Inhibitors or Angiotensin Receptor Blockers be Switched to Other Antihypertensive Drugs to Prevent or Improve Prognosis of Novel Coronavirus Disease 2019 (COVID-19)? (2020) (22)
Synthesis, characterization and pharmacological profile of tropicamide enantiomers. (1996) (22)
An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown (2008) (22)
The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction. (2013) (22)
New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular modeling investigation. (2010) (22)
Antidepressant phenotype by inhibiting the phospholipase Cβ1 – Protein kinase Cγ pathway in the forced swim test (2011) (22)
4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action. (2007) (22)
St. John's wort reversal of meningeal nociception: a natural therapeutic perspective for migraine pain. (2013) (21)
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. (2019) (21)
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief. (2011) (21)
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat (2014) (21)
Stereoselective Increase in Cholinergic Transmission by R-(+)-hyoscyamine (1997) (21)
Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism. (2009) (21)
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. (2003) (21)
Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. (2011) (21)
A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin (2017) (21)
St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes. (2014) (21)
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. (2017) (21)
Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine‐induced acute thermal nociception (2008) (21)
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. (2014) (21)
Hybridized and isosteric analogues of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action. (1999) (21)
Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline (2012) (20)
Antinociceptive profile of the new nicotinic agonist DBO‐83 (1997) (20)
Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain (2016) (20)
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice. (2010) (20)
Presynaptic auto- and hetero-receptors in the cholinergic regulation of pain (1992) (20)
Methylamine‐dependent release of nitric oxide and dopamine in the CNS modulates food intake in fasting rats (2007) (20)
Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine. (2004) (19)
Role of Gi Proteins in the Antidepressant-like Effect of Amitriptyline and Clomipramine (2002) (19)
A reduced functionality of Gi proteins as a possible cause of fibromyalgia. (2001) (19)
Development of a chitosan-derivative micellar formulation to improve celecoxib solubility and bioavailability (2014) (19)
Role of 5-HT1A receptors in a mouse passive avoidance paradigm. (2000) (19)
Environmental training is beneficial to clinical symptoms and cortical presynaptic defects in mice suffering from experimental autoimmune encephalomyelitis (2018) (19)
Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors. (2015) (19)
Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy (2015) (19)
Prochlorperazine induces central antinociception mediated by the muscarinic system. (2004) (19)
Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity. (2019) (19)
Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship (2020) (19)
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology. (2018) (19)
Reversal of NO-induced nociceptive hypersensitivity by St. John’s wort and hypericin: NF-κB, CREB and STAT1 as molecular targets (2013) (19)
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity. (2015) (19)
Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. (2015) (19)
Role of intracellular calcium in acute thermal pain perception (2004) (18)
PPAR-γ Impairment Alters Peroxisome Functionality in Primary Astrocyte Cell Cultures (2014) (18)
Nanostructured lipid carriers for oral delivery of silymarin: improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model. (2019) (18)
The role of potassium channels in antihistamine analgesia (1999) (18)
St. John's wort relieves pain in an animal model of migraine (2013) (18)
Pharmacological identification of SM-21, the novel sigma(2) antagonist. (2000) (18)
Inhibition of spinal ERK1/2-c-JUN signaling pathway counteracts the development of low doses morphine-induced hyperalgesia. (2015) (18)
Protective Effects Induced by Two Polyphenolic Liquid Complexes from Olive (Olea europaea, mainly Cultivar Coratina) Pressing Juice in Rat Isolated Tissues Challenged with LPS (2019) (18)
Improving the therapeutic efficacy of prilocaine by PLGA microparticles: Preparation, characterization and in vivo evaluation (2018) (18)
Effect of K+ channel modulation on mouse feeding behaviour. (1997) (18)
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram) (2003) (18)
Amitriptyline and clomipramine activate Gi-protein signaling pathway in the induction of analgesia (2001) (18)
Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin (2019) (17)
Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers. (2006) (17)
S-(-)-ET 126: a potent and selective M1 antagonist in vitro and in vivo. (1995) (17)
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain. (2008) (17)
Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence (2018) (17)
Activity and expression of semicarbazide-sensitive benzylamine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-aminoguanidine. (2006) (17)
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold. (2019) (16)
Antihistamine antinociception is mediated by Gi-protein activation (2002) (16)
Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABAA) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity. (2017) (16)
Synergic stimulation of serotonin 5‐HT1A receptor and &agr;2‐adrenoceptors for neuropathic pain relief: Preclinical effects of 2‐substituted imidazoline derivatives☆ (2017) (16)
Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels. (2020) (16)
Widespread pain reliever profile of a flower extract of Tanacetum parthenium. (2015) (16)
Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry (2018) (16)
Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG-9. (1998) (16)
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. (2008) (16)
Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice (2019) (16)
Pomegranate Mesocarp against Colitis-Induced Visceral Pain in Rats: Effects of a Decoction and Its Fractions (2020) (16)
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage. (2007) (16)
Involvement of central cholinergic system in antinociception induced by sumatriptan in mouse. (1997) (15)
PKC-mediated potentiation of morphine analgesia by St. John's Wort in rodents and humans. (2014) (15)
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain (2018) (15)
Different Apoptotic Pathways Activated by Oxaliplatin in Primary Astrocytes vs. Colo-Rectal Cancer Cells (2015) (15)
N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties. (2019) (15)
Diphenhydramine-induced amnesia is mediated by Gi-protein activation (2003) (15)
The H2S-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells (2021) (15)
Combined Approach of Cyclodextrin Complexationand Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide (2018) (15)
Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi‐protein α subunits (2001) (15)
Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain. (2015) (15)
Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release. (2013) (14)
Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat (2017) (14)
Inhibition of the PKCγ-ε Pathway Relieves from Meningeal Nociception in an Animal Model: An Innovative Perspective for Migraine Therapy? (2013) (14)
Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1 (2019) (14)
Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis. (2014) (14)
Bioisosteric Development of Multi-target Nonsteroidal Anti-inflammatory Drug - Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. (2020) (14)
Modifications on the amino-3,5-dicyanopyridine core to obtain multifaceted adenosine receptor ligands with antineuropathic activity. (2019) (14)
Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide (2018) (14)
Pharmacological in vivo test to evaluate the bioavailability of some St John's Wort innovative oral preparations (2009) (14)
No development of tolerance to analgesia by repeated administration of H1 antagonists. (1998) (13)
Antisense Knockdown of the Shaker-like Kv1.1 Gene Abolishes the Central Stimulatory Effects of Amphetamines in Mice and Rats (2003) (13)
BDNF and ARTEMIN are increased in drug-naïve non-depressed GAD patients: Preliminary data (2014) (13)
Anti-mu opioid antiserum against the third external loop of the cloned mu-opioid receptor acts as a mu receptor neutral antagonist. (2003) (13)
Novel formyl peptide receptors (FPRs) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis. (2020) (13)
Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands. (2017) (13)
(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. (2020) (13)
Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: An antisense study (2008) (13)
Adenosine A 3 receptor activation inhibits pronociceptive N-type Ca 2+ currents and cell excitability in dorsal root ganglion neurons (2019) (13)
Involvement of PLC-β3 in the effect of morphine on memory retrieval in passive avoidance task (2010) (13)
Bacopa monnieri as augmentation therapy in the treatment of anhedonia, preclinical and clinical evaluation (2020) (13)
Antinociceptive property of the nicotinic agonist AG‐4 in rodents (1997) (13)
Efficacy of isothiocyanate-based compounds on different forms of persistent pain (2018) (13)
Ultramicronized N-Palmitoylethanolamine Supplementation for Long-Lasting, Low-Dosed Morphine Antinociception (2018) (13)
Chiral Aryloxyalkylamines: Selective 5‐HT1B/1D Activation and Analgesic Activity (2010) (12)
Altered Expression of Cytoskeletal and Axonal Proteins in Oxaliplatin-Induced Neuropathy (2016) (12)
Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats (2017) (12)
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme. (2012) (12)
Intra-Articular Route for the System of Molecules 14G1862 from Centella asiatica: Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis (2020) (12)
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists. (2015) (12)
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. (2016) (12)
Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype (2021) (12)
Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side Effect (2021) (12)
Adenosine A3 receptor activation inhibits pro-nociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. (2019) (12)
Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence (2021) (12)
Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. (2011) (12)
Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype (2004) (11)
Antioxidant-conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain. (2019) (11)
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235. (2015) (11)
Involvement of the serotoninergic system in the analgesic effect of tricyclic antidepressants: 4.4 (1995) (11)
Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations (2017) (11)
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). (2017) (11)
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers. (2008) (11)
Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activity. (2019) (11)
Synthesis and biological evaluation of chiral alpha-aminoanilides with central antinociceptive activity. (2007) (11)
Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis. (2016) (11)
Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors (2020) (11)
VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody (2021) (11)
St. John’s Wort Potentiates anti-Nociceptive Effects of Morphine in Mice Models of Neuropathic Pain (2016) (11)
In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP‐505 (2018) (11)
Kv1.1 channel antisense attenuates learning and modulation of dentate polysialylated NCAM (1998) (11)
Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia (1998) (11)
Eruca sativa Mill. seed extract promotes anti‐obesity and hypoglycemic effects in mice fed with a high‐fat diet (2020) (11)
Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression (2017) (11)
Stereoselectivity in central analgesic action of tocainide and its analogs. (1993) (11)
Intra‐articular mucilages: behavioural and histological evaluations for a new model of articular pain (2019) (10)
Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells. (2019) (10)
A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam. (2015) (10)
Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain (2014) (10)
The Versatile 2‐Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5‐HT1A Receptor (2016) (10)
Methylamine: a new endogenous modulator of neuron firing? (2005) (10)
Antinociceptive Profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): A Novel Analgesic with a Presynaptic Cholinergic Mechanism of Action (1997) (10)
α-2 agonists induce amnesia through activation of the Gi-protein signalling pathway (2004) (10)
Nociceptin/orphanin FQ receptor and pain: Feasibility of the fourth opioid family member. (2015) (10)
Selective inhibition of amine oxidases differently potentiate the hypophagic effect of benzylamine in mice. (2001) (10)
Synthesis and enantioselectivity of the enantiomers of PG9 and SM21, new potent analgesic and cognition-enhancing drugs. (1996) (10)
Injectable liposomal formulations of opiorphin as a new therapeutic strategy in pain management (2015) (10)
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors. (2016) (10)
Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis (2019) (10)
Acetyl-L-Carnitine in the Management of Pain During Methadone Withdrawal Syndrome (2008) (10)
Treatment with acetyl-L-carnitine exerts a neuroprotective effect in the sciatic nerve following loose ligation: a functional and microanatomical study (2018) (9)
β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity (2020) (9)
Increase of neurofilament-H protein in sensory neurons in antiretroviral neuropathy: Evidence for a neuroprotective response mediated by the RNA-binding protein HuD. (2016) (9)
Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells (2021) (9)
Development and characterization of fast dissolving tablets of oxaprozin based on hybrid systems of the drug with cyclodextrins and nanoclays. (2017) (9)
Benzylamine-related compounds stimulate rat vas deferens neurotransmission and potentiate memory in the mouse acting as potassium channel blockers. (2000) (9)
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action. (2021) (9)
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII (2022) (9)
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent. (2005) (9)
Neuropathy‐induced apoptosis: Protective effect of physostigmine (2009) (9)
The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model (2009) (9)
The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis. (2020) (9)
Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators. (2017) (9)
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. (2008) (9)
Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels (2020) (9)
Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity (1997) (9)
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties. (2007) (9)
The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis (2020) (9)
Dual effect of morphine in long‐term social memory in rat (2013) (9)
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. (2009) (9)
Spinal astrocytic c‐Jun N‐terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies (2017) (8)
Apoptotic Process Induced by Oxaliplatin in Rat Hippocampus Causes Memory Impairment (2017) (8)
Ryanodine receptors are involved in muscarinic antinociception in mice (2005) (8)
Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test. (1997) (8)
Design, Synthesis, and Biological Activity of Methoctramine-Related Polyamines as Putative Gi Protein Activators (2001) (8)
Influence of oestrogens on muscarinic receptor density and contractile response in the guinea-pig uterus. (1996) (8)
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy (2020) (8)
The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats (2002) (8)
Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents. (2015) (8)
Involvement of the N/OFQ‐NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad? (2018) (8)
Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. (2011) (8)
The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity (2020) (8)
Differentiation state affects morphine induced cell regulation in neuroblastoma cultured cells (2013) (8)
Analgesic, antimuscarinic activity and enantioselectivity of the four isomers of 3-quinuclidinyl tropate as compared with the enantiomers of hyoscyamine. (1995) (8)
Involvement of central cholinergic neurotransmission in metoclopramide analgesia. (1992) (8)
2-pyrrolidinone moiety is not critical for the cognition-enhancing activity of piracetam-like drugs. (2003) (8)
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents. (2017) (8)
Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice (2021) (8)
Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins. (2005) (8)
Gi/o proteins: expression for direct activation enquiry. (2006) (7)
α2-Agonists as Analgesic Agents (2009) (7)
Antinociceptive profile of 3-alpha-tropanyl 2-(4-Cl-phenoxy)butyrate (SM-21) [corrected]: a novel analgesic with a presynaptic cholinergic mechanism of action. (1997) (7)
Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands. (2007) (7)
Contribution of G inhibitory protein alpha subunits in paradoxical hyperalgesia elicited by exceedingly low doses of morphine in mice. (2011) (7)
Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models (2021) (7)
The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms. (2020) (7)
Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis (2022) (7)
Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy (2021) (7)
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. (2012) (7)
3-α-tropanyl 2-(4-Cl-phenoxy)butyrate (SM 21): A Review of the Pharmacological Profile of a Novel Enhancer of Cholinergic Transmission (1997) (7)
Role of Carbonic Anhydrase in Cerebral Ischemia and Carbonic Anhydrase Inhibitors as Putative Protective Agents (2021) (7)
The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4+ T Cells (2021) (6)
Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity. (2021) (6)
New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease (2021) (6)
Piracetam and aniracetam antagonism of centrally active drug-induced antinociception (1996) (6)
Synthesis and Pharmacological Evaluation of Novel GABAA Subtype Receptor Ligands with Potential Anxiolytic-like and Anti-hyperalgesic Effect (2017) (6)
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands. (2022) (6)
Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: Potential role of hydrogen sulfide (2022) (6)
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain. (2021) (6)
1H-NMR and HPLC-DAD-MS for the characterization of ellagitannins and triterpenoids of less investigated Anogeissus leiocarpus DC (Combretaceae) stem bark (2021) (6)
Improvement of Butamben Anesthetic Efficacy by the Development of Deformable Liposomes Bearing the Drug as Cyclodextrin Complex (2021) (6)
N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance (2021) (6)
Pharmacological Characterization of the Novel ACh Releaser α‐tropanyl 2‐(4‐bromophenyl)propionate (PG‐9) (2006) (6)
Effects of the Combination of β-Hydroxy-β-Methyl Butyrate and R(+) Lipoic Acid in a Cellular Model of Sarcopenia (2020) (5)
Toxicological Profile of the Pain-Relieving Antioxidant Compound Thioctic Acid in Its Racemic and Enantiomeric Forms (2020) (5)
A Series of COX‐2 Inhibitors Endowed with NO‐Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis (2016) (5)
Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis (2022) (5)
Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats (2015) (5)
Role of Enteric Glia as Bridging Element between Gut Inflammation and Visceral Pain Consolidation during Acute Colitis in Rats (2021) (5)
Studies on the analgesic mechanism of some antiarrhythmic drugs (1988) (5)
Extra virgin olive oil and related by-products (Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats. (2020) (5)
The Anti-Arthritic Efficacy of Khellin Loaded in Ascorbyl Decanoate Nanovesicles after an Intra-Articular Administration (2021) (5)
Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice (2022) (5)
Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of cyclodextrins and hydrophilic polymers. (2020) (5)
Mesenchymal stem cells, implications for pain therapy (2019) (5)
The reduction of food intake induced in mice by benzylamine and its derivatives (2004) (5)
Lipid Cubic Mesophases Combined with Superparamagnetic Iron Oxide Nanoparticles: A Hybrid Multifunctional Platform with Tunable Magnetic Properties for Nanomedical Applications (2021) (5)
Antinociceptive effect of R-(+)-hyoscyamine on the conjunctival reflex test in rabbits. (1999) (5)
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. (1996) (5)
Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources (2021) (5)
Comparative Assessment of the Activity of Racemic and Dextrorotatory Forms of Thioctic (Alpha-Lipoic) Acid in Low Back Pain: Preclinical Results and Clinical Evidences From an Open Randomized Trial (2021) (4)
Abstracts of poster presentationsR-(+)-hyoscyamine: The first selective antagonist for guinea-pig uterus muscarinic receptor subtype (1993) (4)
Peroxisome determination in optical microscopy: a useful tool derived by a simplification of an old ultrastructural technique. (2014) (4)
Design, synthesis and binding affinity of new nicotinic ligands (2006) (4)
Faecal microbiota transplant from aged donor mice into young recipients affects spatial learning and memory (2019) (4)
Reduced Flexibility Analogs of Analgesic and Cognition Enhancing α‐Tropanyl Esters (1996) (4)
Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis. (2020) (4)
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors. (2019) (4)
Precision Medicine in Alzheimer’s Disease: Investigating Comorbid Common Biological Substrates in the Rat Model of Amyloid Beta-Induced Toxicity (2022) (4)
Synthesis and biological activity of a series of aryl tropanyl esters and amides chemically related to 1H-indole-3-carboxylic acid endo 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester. Development of a 5-HT4 agonist endowed with potent antinociceptive activity. (1993) (4)
Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis (2021) (4)
Antinociceptive profile of the natural cholinesterase inhibitor huperzine A (2001) (4)
SAR Studies on the Potent and Selective Muscarinic Antagonist 2‐Ethylthio‐2,2‐diphenylacetic Acid N,N‐Diethylaminoethyl Ester (1997) (4)
Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study (2020) (4)
Central muscarinic antinociception induced by ET‐142 and SS‐20 in rodents (1997) (4)
Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain (2022) (4)
In vitro characterization of a novel, potent and selective M3 antagonist. (1997) (3)
The stimulating action of very low doses of antagonist drugs, or the otherwise generally higher sensitivity of presynaptic autoreceptors (1988) (3)
The antimigraine drug ergotamine is endowed with antihyperalgesic activity (1998) (3)
Oxaliplatin-induced neuropathy: glial activation in spinal cord and brain (2010) (3)
Antinociception induced by SM 32 depends on a central cholinergic mechanism. (1997) (3)
Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice (2007) (3)
4‐methyl benzylamine stimulates food consumption and counteracts the hypophagic effects of amphetamine acting on brain Shaker‐like Kv1.1 channels (2006) (3)
P.1.f.003 An immunologic profile study in drug-näive generalized anxiety non depressed patients: a pilot study (2015) (3)
P060 Post-inflammatory visceral pain induced by DNBS: Preclinical features for novel therapeutics (2018) (3)
Antihyperalgesic Effect of Eschscholzia Californica in Rat Models of Neuropathic Pain (2008) (3)
The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model (2022) (3)
Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis (2021) (3)
Beneficial Effects of Eruca sativa Defatted Seed Meal on Visceral Pain and Intestinal Damage Resulting from Colitis in Rats (2022) (3)
Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents. (2020) (3)
Methoctramine increases cholinergic neurotransmission by acting presynaptically (1990) (3)
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats (2021) (2)
New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies (2022) (2)
Interaction of Half Oxa-/Half cis-Platin Complex with Human Superoxide Dismutase and Induced Reduction of Neurotoxicity. (2018) (2)
Antihistaminic antinociception: Research about mechanism of action (1988) (2)
A recombinant transductor-effector system: in vitro study of G inhibitory protein (G-alpha-i1) direct activators. (2006) (2)
Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism (2022) (2)
Antiamnesic activity of the nicotinic agonist DBO‐83 in mice (1998) (2)
PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior (2013) (2)
Improvement of cognitive functions by the acetylcholine releaser SM 21 (1999) (2)
Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits (2022) (2)
Escinosomes: Safe and Successful Nanovesicles to Deliver Andrographolide by a Subcutaneous Route in a Mice Model of Oxaliplatin-Induced Neuropathy (2022) (2)
Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation (2020) (2)
Further structure-activity relationships in the series of tropanyl esters endowed with potent antinociceptive activity. (1998) (2)
Restorative and pain-relieving effects of fibroin in preclinical models of tendinopathy. (2022) (2)
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties. (2022) (2)
In vitro and in vivo characterisation of the bifunctional MOP / DOP ligand UFP-505 (2018) (2)
Anti-Inflammatory Effect of the Natural H2S-Donor Erucin in Vascular Endothelium (2022) (2)
Morpho-functional evaluation of the activity of stereoisomers of the antioxidant alpha-lipoic (tioctic) acid in a model of compressive neuropathy (2010) (2)
The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief (2022) (2)
Design and synthesis of the first indole-based blockers of Panx-1 channel. (2021) (2)
Beneficial Effect of H2S-Releasing Molecules in an In Vitro Model of Sarcopenia: Relevance of Glucoraphanin (2022) (2)
Effects of Ultramicronized N-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention (2022) (2)
Receptor-independent modulation of reconstituted Galpha(i) protein mediated by liposomes. (2009) (2)
Antiamnesic effect of the two novel κ‐opioid agonists, VA‐100 and VA‐101, in the mouse passive avoidance test (2001) (2)
Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour (2022) (2)
Therapeutic option by synergistic administration of the β-hydroxy-β-methyl butyrate and R(+) Lipoic Acid in a cellular model of dexamethasone-dependent sarcopenia (2015) (1)
Memory facilitation with atropine: a paradoxical effect (1998) (1)
Amitriptyline Activity is Associated with Synaptic Marker Changes in the Hippocampus of Mice Exposed to Experimental Models of Depression (2015) (1)
Protective action by the new cholinergic amplifier sm 21 on hypoxia-induced amnesia (1994) (1)
(421) A novel, non-opioid, conesnail peptide-based analgesic as a therapeutic alternative for the treatment of chronic pain. (2016) (1)
Thioctic acid enantiomers prevent central nervous system changes occurring in a model of compressive neuropathy (2011) (1)
Ultramicronized N-palmitoylethanolamine contributes to morphine efficacy against neuropathic pain: implication of mast cells and glia. (2022) (1)
ATOMOXETINE FOR HOARDING DISORDER: A PRECLINICAL AND CLINICAL INVESTIGATION (2017) (1)
Central antinociceptive effect of minaprine (1990) (1)
Effects of thioperamide and (R)-α-methylhistamine in antinociception (1992) (1)
Anabasine is a nicotinic analgesic (1995) (1)
Mechanism of the antinociceptive effect of bicuculline and picrotoxin (1990) (1)
Investigation into analgesia induced by haloperidol (1990) (1)
The enkephalinase inhibitor thiorphan greatly potentiates antinociception induced by very low doses of naloxone (1989) (1)
Hypericum perforatum L. as adjuvant to opioid analgesia in an animal model of migraine. (2014) (1)
IL-1 alpha and modulation of spinal glutamate release: protection against oxaliplatin-induced neuropathic pain (2017) (1)
Interferon-gamma and neuropathy: balance between pain and neuroprotection (2022) (1)
Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (Olea europaea, Mainly Cultivar coratina): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis (2022) (1)
Development of Eudragit® Nanoparticles for Intranasal Drug Delivery: Preliminary Technological and Toxicological Evaluation (2022) (1)
Involvement of Alpha7 nAC hR downregulation in rat oxaliplatin-induced neuropathy (2012) (1)
Efficacy Evaluation of Plant Products in the Treatment of Erectile Dysfunction Related to Diabetes (2021) (1)
Cross-tolerance between baclofen and bicuculline antinociception. (1990) (1)
α-Tropanyl esters that increase central ach release: Enantioselectivity studies support a double mechanism of action☆ (1995) (1)
Design, Synthesis, and Preliminary Pharmacological Evaluation of 1,4-Diazabicyclo[4.3.0]nonan-9-ones as a New Class of Highly Potent Nootropic Agents. (2010) (1)
Presynaptic cholinergic mechanism of R-(+) hyoscyamine activity: In vitro studies (1992) (1)
Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels (2022) (1)
Procaine dramatically increases evoked tritium efflux from guinea-pig ileum preloaded with [3H]-choline (1988) (0)
Inactivation of Gi proteins induces an antidepressant-like effect in the mouse forced-swimming test (2002) (0)
ICS-205930 and MDL-72222 protection of amnesia induced by scopolamine and hypoxia in mice (1995) (0)
Molecular simplification of DM232 and DM235, two new potent cognition enhancers (2002) (0)
Escinosome thermosensitive gel optimizes efficacy of CAI-CORM in a rat model of rheumatoid arthritis. (2023) (0)
VEGF-A/VEGFR-1: a painful astrocyte-mediated signaling blocked by the anti-VEGFR-1 mAb D16F7 (2021) (0)
Buspirone and gepirone: two anxiolytic drugs endowed with antinociception mediated by the cholinergic system (1995) (0)
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 (2015) (0)
Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology (2018) (0)
Glia inhibition suppresses chemotherapy-induced neuropathic pain in the rat (2013) (0)
Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression (2021) (0)
Neurorestoration from medicinal plants: an opportunity to treat painful neuropathies (2017) (0)
Role of the shaker-like Kv1.1 potassium channel in mouse cognitive processes (1998) (0)
Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related Disorders (2022) (0)
Using extracts of Hypericum perforatum in the treatment of neuropathic pain (2009) (0)
Reduced flexibility analogs of analgesic and cognition enhancing alpha-tropanyl esters. (1996) (0)
Furanoeudesma-1,3-diene, A sesqiterpene from MYRRH, is a specific agonist of opiod delta receptors (1995) (0)
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy (2023) (0)
receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress Running head : neuronal H 4 R in neuropathic pain (2016) (0)
An in vivo study on oxaliplatin-induced neuropathicpain : the protective effects of antioxidant compounds. (2011) (0)
CARDIOVASCULAR EFFECTS OF A NEW NO-RELEASING COXIB DERIVATIVE (2011) (0)
Spinal cord changes consequent to peripheral nerve injury: neuroprotective role of thioctic acid enantiomers (2013) (0)
Inhibition of the PKCγ-ε Pathway Relieves from Meningeal Nociception in an Animal Model: An Innovative Perspective for Migraine Therapy? (2012) (0)
Effect of novel polyphenol compound from yeast-like fungi Nadsoniella nigra sp. X1 (Antarctica) Melanin on serum cytokine profile in patients with advanced urological cancer in the adjuvant setting (2017) (0)
Allosteric modulation of α7 nicotinic acetylcholine receptors downregulates inflammatory mediators in glial cells and inhibits chemotherapy-induced neuropathic pain in mice (2021) (0)
Evaluation of single and associated botanicals on glucose tolerance in glucose induced hyperglycemic mice (2022) (0)
Abdominal pain models: mechanisms and therapies and experimental models (2020) (0)
Supplementary Material for: Altered Expression of Cytoskeletal and Axonal Proteins in Oxaliplatin-Induced Neuropathy (2016) (0)
ACTIVITY OF THIOCTIC ACID ENANTIOMERS ONSPINAL CORD CHANGES CONSEQUENT TOPERIPHERAL NERVE INJURY (2013) (0)
Differential contribution of Gαi/o subunits in the response to food deprivation. (2015) (0)
New 1,5-diphenyl pyrrole derivatives as anti-inflammatory COX-2 selective compounds and their use as potential antitumoral agents. (2012) (0)
Lack of antidepressant-like effect of oleoylethanolamide in histamine-deficient mice parallels reduced hippocampal and cortical CREB phosphorylation (2016) (0)
Pharmacological in vivo test to evaluate the bioavailability of some St. John's wort innovative oral preparations (2006) (0)
Binding Profiles of a Series of 2-Arylpropionic Acid Esters on Cloned Human Muscarinic Receptor Subtypes (m1-m5) and Their Relationship to Nootropic Activity (1999) (0)
PAM-2 decreases neuropathic pain in mice and modulates chemokine/cytokine production in human microglial cells (2020) (0)
Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. (2018) (0)
VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody (2021) (0)
Synthesis and evaluation of new chiral molecules with central antinociceptive activity (2006) (0)
Pro-cognitive activity induced in the rat by low doses of R-(+)-hyoscyamine. (2000) (0)
Antinociceptive effect of atropine-like compound SM 32 in mice and rats (1993) (0)
New Pyrrole-based selective COX-2 inhibiting nitric oxide donors: synthesis, in vitro and in vivo evaluation (2011) (0)
P16-11 In search of sensitive safety biomarkers of peripheral neurotoxicity in the rat: a collaborative effort across industry and academia (IMI NeuroDeRisk project) (2022) (0)
DIFFERENT METABOLIC ROUTES EXHIBITED BY THE NITROOXY-ALKYL CHAIN OF NO-NAPROXENE AND A NEW NO-RELEASING COXIB DERIVATIVE (2011) (0)
Role of 5HT4 receptor subtype in central antinociception (1992) (0)
Effect of GM1 ganglioside on amnesia, convulsions and death caused by hypoxia in mice (1990) (0)
Effect of procaine on learning and hypoxia-induced amnesia (1988) (0)
Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients (2020) (0)
USE OF Hypericum perforatum-EXTRACTS IN THE TREATMENT OF PAIN NEUROPATHIC (2009) (0)
Role of the Shaker-like Kv1.1 potassium channel in mouse cognitive processes (1999) (0)
Affinity profile of S(-)-hyoscyamine for muscarinic receptor subtypes☆ (1993) (0)
379 ALTERATIONS IN NEURON AND GLIA GENE EXPRESSION PROFILE AS ACTORS INVOLVED IN THE MECHANISM OF OXALIPLATIN‐DEPENDENT NEUROPATHY (2010) (0)
The Role of TRPA1 and TRPV1 Channels in Orofacial Pain (2015) (0)
Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence (2018) (0)
P1.g.023 Atomoxetine for hoarding disorder: a preclinical and clinical investigation (2015) (0)
Improving the solubility and the biological profile of a novel class of derivatives as selective COX-2 inhibiting nitric oxide donors (2013) (0)
Glutamatergic system modulators as agents in prevention and management of chemotherapy-induced polyneuropathy (2015) (0)
M 1 receptor activation is a requirement for arecoline analgesia (cid:1) (2001) (0)
Effects of the calcium-channel blockers darodipine and nimodipine on amnesia induced by three different hypoxic methods (1994) (0)
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. (2015) (0)
Alpha7 nAChR: pathogenesis and treatment of chemotherapy-induced neuropathy (2012) (0)
DRUG RESEARCH AND INNOVATIVE TREATMENTS (2022) (0)
Ellagitannins and triterpenoids extracts of Anogeissus leiocarpus stem bark extracts: Protective effects against osteoarthritis. (2023) (0)
NiK-13317, a novel dimiracetam derivative for the treatment of neurophatic pain (2004) (0)
ANTIDEPRESSANT-LIKE ACTIVITY OF NOVEL IMIDAZOLINE LIGANDS DIRECTED TO THE SEROTONIN 5-HT1A RECEPTOR (2016) (0)
Procaine antidepressant effect (1988) (0)
Are the contractions of rabbit peripheral lung, guinea-pig gall-bladder and guinea-pig uterus mediated by identical receptor subtype? (1995) (0)
Pain Relieving Eect of-NSAIDs-CAIs HybridMolecules: Systemic and Intra-Articular Treatmentsagainst Rheumatoid Arthritis (2019) (0)
Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits (2022) (0)
Effects of Dimiracetam on oxaliplatin-induced hyperalgesia and allodynia in the rat. (2015) (0)
Morphine tolerance is inhibited by chronic treatment with GM1 ganglioside (1990) (0)
Cadmium-induced neurotoxicity: impairment of the blood brain barrier (2016) (0)
New Pyrrole Derivatives as Anti-inflammatory and Analgesic Agents: Design, Synthesis and Biological Evaluation (2012) (0)
Errata corrigeProcaine dramatically increases evoked tritium efflux from guinea-pig ileum preloaded with [3H]choline (1989) (0)
Astragalus membranaceus and oxaliplatin-induced neuropathy: pain relief and prevention of nervous tissue modifications (2014) (0)
Eect of potassium channel modulators in mouse forced swimming test (1999) (0)
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators. (2001) (0)
Modulation of visceral sensitivity by faecal microbiota transplantation (FMT): the active role of gut microbiota in the persistence of abdominal pain (2020) (0)
Efficacy of a vegetal mixture composed of Zingiber officinale, Echinacea purpurea, and Centella asiatica in a mouse model of neuroinflammation: In vivo and ex vivo analysis (2022) (0)
Histamin H1-antagonists antinociception in mice and inhibition of histamine-N-methyltransferase (1995) (0)
Antihyperalgesic activity of salvianolic acid B and its formulations in the chronic constriction injury of the sciatic nerve (CCI) model of neuropatic pain (2010) (0)
Novel Insights on CAI-CORM Hybrids: Evaluation of the CO Releasing Properties and Pain-Relieving Activity of Differently Substituted Coumarins for the Treatment of Rheumatoid Arthritis. (2023) (0)
K+-channel openers: A mouse experimental model of alzheimer disease (1995) (0)
Reversal of NO-induced nociceptive hypersensitivity by St. John’s wort and hypericin: NF-κB, CREB and STAT1 as molecular targets (2012) (0)
Amplification of cholinergic neurotransmission induced by the selective muscarinic M2 antagonist AFDX-116 (1990) (0)
SARDINIAN ALCOHOL PREFERRING RATS: WHAT CAN WE LEARN FROM THEM? (1996) (0)
Title Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain Permalink (2016) (0)
Influence of metal doping on the magnetic and hyperthermic properties of ferrite nanoparticles (2017) (0)
Pyrroloimidazolderivate, verfahern for their manufacture, compositions containing them and their use as nootropics (2004) (0)
The Antinociceptive Activity of (E)-3-(thiophen-2-yl)-N-(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)-N-methyl-N-(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor. (2023) (0)
Echinacea purpurea against neuropathic pain: Alkamides versus polyphenols efficacy. (2022) (0)
Delay of Morphine Tolerance by Palmitoylethanolamide Lorenzo Di (2015) (0)
Design, synthesis and preliminary pharmacological evaluation of alkylderivatives of 4-aminopiperidine as N-type calcium channels blockers (2003) (0)
Curcumin-in-Cyclodextrins-in-Liposomes: An Alternative for Osteoarthritis Treatment (2020) (0)
MU OPIOID RECEPTOR: ROLE FOR THE THIRD EXTERNAL LOOP AS A DETERMINANT OF LIGAND BINDING AFFINITY (2003) (0)
Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis (2019) (0)
Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance (2023) (0)
P-2-26 Involvement of serotoninergic system in the analgesic effect of tricyclic antidepressants (1995) (0)
Therapeutic Potential of Highly Selective A3 Adenosine Receptor Ligands in the Central and Peripheral Nervous System (2022) (0)
Involvement of central cholinergic system in analgesia induced by the 5HT4 agonists (1992) (0)
Aminopyridine-3,5-dicarbonitriles as non-nucleoside adenosine A1 receptor agonists. (2015) (0)
Antihyperalgesic activity of verbascoside in the chronic constriction injury of the sciatic nerve (CCI) and intra-articular injection of sodium monoiodoacetate (MIA) models of neuropatic pain (2009) (0)
Sa1311 – Anti-Inflammatory and Visceral Pain Relieving Effects of Ar170, a Potent and Selective A3 Receptor Agonist, in a rat Model of Colitis (2019) (0)
Nicotine psychopharmacology in animals (1994) (0)
PAIN RELIEVER EFFECT OF 2-SUBSTITUTED IMIDAZOLINE DERIVATIVES IN A RAT MODEL OF PERIPHERAL NEUROPATHY (2016) (0)
AG‐4: a nicotinic agonist endowed with antiamnesic properties (2000) (0)
[35S]GTP gamma S binding studies of amphiphilic drugs-activated Gi proteins: a caveat. (2009) (0)
Pharmacological Profile of MP-101, a Novel Non-racemic Mixture of R- and S-dimiracetam with Increased Potency in Rat Models of Cognition, Depression and Neuropathic Pain (2022) (0)
Erratum to (421) a novel, non-opioid, conesnail peptide-based analgesic as a therapeutic alternative for the treatment of chronic pain. J Pain 17:S79-S80, 2016. (2017) (0)
Effect of 5-HT4 agonists metoclopramide and compound 1 on learning and memory (1993) (0)
Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects (2018) (0)
Pyrroloä1,2-aüimidazoldion for treatment of peripheral neuro-toxicity of chemotherapeutic agents (2007) (0)
Functional investigation of muscarinic receptor subtype mediating ACh-induced contractions in guinea-pig gallbladder (1994) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Carla Ghelardini?

Carla Ghelardini is affiliated with the following schools:

University of Florida
University of Siena
University of Florence

Carla Ghelardini's Academic­Influence.com Rankings

Why Is Carla Ghelardini Influential?

Carla Ghelardini's Published Works

Published Works

What Schools Are Affiliated With Carla Ghelardini?

Carla Ghelardini's AcademicInfluence.com Rankings