Carla Koehler
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American biochemist
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Carla Koehlerbiology Degrees
Biology
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Biochemistry
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#2705
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Biology
Carla Koehler's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Biochemistry University of California, Davis
Why Is Carla Koehler Influential?
(Suggest an Edit or Addition)According to Wikipedia, Carla M. Koehler is an American biochemist who is a professor at the University of California, Los Angeles. Her research considers mitochondria and the processes which import proteins to their appropriate locations in the organelles. She was elected Fellow of the American Association for the Advancement of Science in 2018.
Carla Koehler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Importing Mitochondrial Proteins: Machineries and Mechanisms (2009) (1240)
- UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells (2011) (469)
- Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. (2012) (402)
- Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. (2009) (331)
- Human deafness dystonia syndrome is a mitochondrial disease. (1999) (330)
- Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. (1998) (309)
- New developments in mitochondrial assembly. (2004) (306)
- PNPASE Regulates RNA Import into Mitochondria (2010) (302)
- The complexity of cardiolipin in health and disease. (2012) (300)
- Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane (2008) (290)
- Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells (2012) (245)
- The Tim9p–Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier (2002) (212)
- Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins (1998) (205)
- Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. (2002) (191)
- Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the ‘acid chain’ hypothesis (1998) (180)
- Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition (2000) (173)
- A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1 (2007) (169)
- Replacement of bovine mitochondrial DNA by a sequence variant within one generation. (1991) (168)
- MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria (2010) (163)
- How membrane proteins travel across the mitochondrial intermembrane space. (1999) (152)
- Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins (2006) (139)
- The small Tim proteins and the twin Cx3C motif. (2004) (137)
- A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. (2007) (137)
- The role of the Tim8p–Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins (2002) (135)
- Mammalian Polynucleotide Phosphorylase Is an Intermembrane Space RNase That Maintains Mitochondrial Homeostasis (2006) (134)
- Different import pathways through the mitochondrial intermembrane space for inner membrane proteins (1999) (132)
- Protein translocation pathways of the mitochondrion (2000) (123)
- Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A (1993) (122)
- In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer (2019) (115)
- Presence of a Member of the Mitochondrial Carrier Family in Hydrogenosomes: Conservation of Membrane-Targeting Pathways between Hydrogenosomes and Mitochondria (2000) (113)
- Correcting human mitochondrial mutations with targeted RNA import (2012) (111)
- Tim18p, a New Subunit of the TIM22 Complex That Mediates Insertion of Imported Proteins into the Yeast Mitochondrial Inner Membrane (2000) (111)
- Correction for The Cardiolipin Transacylase, Tafazzin, Associates with Two Distinct Respiratory Components Providing Insight into Barth Syndrome (2008) (110)
- A New Function in Translocation for the Mitochondrial i-AAA Protease Yme1: Import of Polynucleotide Phosphorylase into the Intermembrane Space (2006) (108)
- Redox pathways of the mitochondrion. (2006) (90)
- The Role of Hot13p and Redox Chemistry in the Mitochondrial TIM22 Import Pathway* (2004) (84)
- A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss. (2012) (82)
- The effect of mitochondrial DNA on milk production and health of dairy cattle (1994) (77)
- A small molecule inhibitor of redox-regulated protein translocation into mitochondria. (2013) (74)
- PNPASE and RNA trafficking into mitochondria. (2012) (72)
- Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS) (2017) (71)
- Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase (2008) (70)
- Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. (2016) (70)
- Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins. (2009) (69)
- The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex. (2004) (69)
- Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia. (2016) (67)
- The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23. (2008) (64)
- Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway (2017) (64)
- Redox regulation of protein folding in the mitochondrial intermembrane space. (2009) (64)
- Barth syndrome mutations that cause tafazzin complex lability (2011) (62)
- Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria (2017) (62)
- Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (2005) (57)
- Defining functional classes of Barth syndrome mutation in humans. (2016) (55)
- Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1 (2014) (54)
- Molecular analysis of cytoplasmic genetic variation in Holstein cows. (1989) (54)
- Defining the Role of Oxygen Tension in Human Neural Progenitor Fate (2014) (53)
- TMEM14C is required for erythroid mitochondrial heme metabolism. (2014) (53)
- Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion (2007) (53)
- Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. (2013) (51)
- UCP 2 regulates energy metabolism and differentiation potential of human pluripotent stem cells (2011) (49)
- Human polynucleotide phosphorylase: location matters. (2007) (46)
- Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation (2010) (40)
- The Essential Function of the Small Tim Proteins in the TIM22 Import Pathway Does Not Depend on Formation of the Soluble 70-Kilodalton Complex (2001) (40)
- Trichomonas vaginalis Hmp35, a Putative Pore-forming Hydrogenosomal Membrane Protein, Can Form a Complex in Yeast Mitochondria* (2003) (38)
- A mitochondrial rhomboid protease. (2003) (38)
- Contiguous X-chromosome Deletion Syndrome Encompassing the BTK, TIMM8A, TAF7L, and DRP2 Genes (2007) (37)
- ER–mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release (2018) (36)
- The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model (2010) (31)
- Serine‐threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae (1997) (30)
- Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation. (2009) (27)
- FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity (2018) (26)
- Defective Mitochondrial Protein Translocation Precludes Normal Caenorhabditis elegans Development* (2004) (25)
- The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. (2007) (25)
- P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. (2016) (25)
- Meiosis I Arrest Abnormalities Lead to Severe Oligozoospermia in Meiosis 1 Arresting Protein (M1ap)-Deficient Mice1 (2013) (25)
- Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space (2017) (24)
- The Role of Tim9p in the Assembly of the TIM22 Import Complexes (2003) (23)
- Role of Twin Cys-Xaa9-Cys Motif Cysteines in Mitochondrial Import of the Cytochrome c Oxidase Biogenesis Factor Cmc1* (2012) (21)
- Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. (2017) (20)
- Molecular machines involved in protein transport across cellular membranes (2007) (19)
- Mitochondrial import of the long and short isoforms of human uncoupling protein 3 (2000) (17)
- Mitochondrial Function and Biogenesis (2004) (16)
- Tim 18 p , a New Subunit of the TIM 22 Complex That Mediates Insertion of Imported Proteins into the Yeast Mitochondrial Inner Membrane (2000) (15)
- New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish. (2013) (15)
- Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44* (2017) (14)
- Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway* (2015) (14)
- PNPase knockout results in mtDNA loss and an altered metabolic gene expression program (2018) (13)
- In Vitro Analysis of Yeast Mitochondrial Protein Import (2007) (13)
- The Taz1p Transacylase Is Imported and Sorted into the Outer Mitochondrial Membrane via a Membrane Anchor Domain (2013) (12)
- UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells (2016) (11)
- Mitochondria-targeted RNA import. (2015) (11)
- Erratum: UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells (EMBO Journal (2011) 30 (4860-4873) DOI:10.1038/emboj.2011.401) (2016) (11)
- Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia (2020) (9)
- Cardiolipin defi nes the interactome of the major ADP / ATP carrier protein of the mitochondrial inner membrane (2008) (7)
- A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B). (2018) (7)
- Recovery of mitochondrial DNA from blood leukocytes using detergent lysis (1992) (6)
- Hereditary Spastic Paraplegia: Respiratory Choke or Unactivated Substrate? (2005) (6)
- Characteristics of mammary mitochondria in lines of mice genetically divergent for milk production. (1989) (6)
- The great escape: Mgr2 of the mitochondrial TIM23 translocon is a gatekeeper Tasked with releasing membrane proteins. (2014) (4)
- Aim32, a dual‐localized 2Fe‐2S mitochondrial protein that functions in redox quality control (2021) (2)
- Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control (2021) (2)
- Tim8-Tim13 complex (2008) (2)
- Dynamin-2 facilitates Atg9 recycling from nascent autophagosomes (2018) (2)
- Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition (2020) (2)
- Mitochondrial biogenesis. Protein import into and across the inner membrane (2004) (2)
- Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer (2020) (2)
- Protein Translocation Across Membranes (2006) (1)
- Human deafness dystonia syndro (2016) (1)
- Tmem14c Plays An Essential Role In Mitochondrial Heme Metabolism (2013) (1)
- Spatial mapping of mitochondrial networks and bioenergetics in lung cancer (2023) (1)
- Reply to: In vivo quantification of mitochondrial membrane potential (2020) (1)
- IA11 Role of the Tumor Microenvironment in Sensitivity and Resistance to Immunostimulatory Therapies in NSCLC (2020) (0)
- Reply to: In vivo quantification of mitochondrial membrane potential (2020) (0)
- Hot13p mediates import and assembly of the small Tim proteins (2006) (0)
- The role of hPNPase, an IFN‐inducible gene, in the hepatocellular innate immune response to HCV infection (2010) (0)
- IA08 Mapping Mitochondrial Heterogeneity in Lung Cancer (2020) (0)
- 2Chemical inhibition of the Erv1 mitochondrial oxidative folding pathway by a small molecule inhibitor (2011) (0)
- 14 – The Function of TIM22 in the Insertion of Inner Membrane Proteins in Mitochondria (2007) (0)
- A New Role for the Mitochondrial Processing Peptidase in Protein Translocation into Mitochondria (2022) (0)
- 769 – Identifying Small Molecules to Correct Abnormal Protein Trafficking of Alanine-Glyoxylate Aminotransferase (AGT) in a Human Cell Model of Primary Hyperoxaluria Type I to Avoid Need for Liver Transplantation (2019) (0)
- Mitochondrial Transfer by Photothermal Nanoblade Restores Respiration in Mammalian Cells with Dysfunctional Mitochondria (2016) (0)
- In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer (2019) (0)
- Abstract 1197: The yeast [2Fe-2S] mitochondrial protein Aim32 supports the formation of cytochrome c oxidase complex (2023) (0)
- Abstract 2818: In vivo imaging of mitochondrial bioenergetics in lung cancer (2021) (0)
- Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane (2012) (0)
- Abstract 1755: A Role for SLC25A46 in Mediating Mitochondrial Dynamics (2023) (0)
- Altered Membrane Association and Complex Formation of Tafazzin in the Absence of Cardiolipin (2006) (0)
- A new assembly pathway in the mitochondrial intermembrane space for mammalian polynucleotide phosphorylase (2006) (0)
- An Innovative Low-Cost Program for Neutral Density and Wind Research With Small Satellites (2007) (0)
- A small molecule probe elucidates the role of mitochondrial translocase TIMM44 in PINK1/Parkin regulated mitophagy (2022) (0)
- Dynamin-2 controls phagophore maturation (2019) (0)
- Modulateurs d'importation de protéine mitochondriale (2012) (0)
- Megaloblastic Anemia and Mitochondriopathy Caused by a Homozygous Mutation in Sideroflexin-4. (2012) (0)
- Aim32p is a Novel Member of the Erv1 Translocation Pathway within the Mitochondrial Intermembrane Space of Saccharomyces cerevisiae (2016) (0)
- Abstract 4360: Distinct energy metabolism in human pluripotent stem cells and differentiated cells regulated by UCP2 (2011) (0)
- Tim54p mediates the assembly of the AAA protease Yme1p (2006) (0)
- Biogenesis of the mitochondrial inner membrane (2000) (0)
- Gazing at Translocation in the Mitochondrion (2008) (0)
- Sideroflexin-4 Defects Cause A New Infantile Mitochondrial Disorder Affecting Hematopoietic And Central Nervous Systems. (P7.328) (2014) (0)
- Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60 (2015) (0)
- Import of membrane‐multispanning proteins into the yeast mitochondrial inner membrane (1998) (0)
- IA09 Identification of New Therapeutic Targets in Non-Small Cell Lung Cancer (2020) (0)
- Topological differences but dysfunctional conservation of cardiolipin remodeling in mammals and yeast (2015) (0)
- Small molecule modulators for mitochondrial protein import (2015) (0)
- Elm1p, a protein kinase that regulates cell morphology in Saccharomyces cerevisiae (1995) (0)
- IA10 Novel Metabolic Functions for Redox Regulators in Non-Small Cell Lung Cancer (2020) (0)
- A Novel Mitochondrial Matrix Serine/Threonine Protein Phosphatase Is Essential to Cardiomyocyte Survival and Cardiac Function by Regulating Mitochondrial Permeability Transition (2006) (0)
- Target of Erythropoietin, Fam210b, Regulates Erythroid Heme Synthesis By Control of Mitochondrial Iron Import and Regulation of Fech Activity (2018) (0)
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