Carla V. Rothlin
Argentinian Immunologist
Carla V. Rothlin's AcademicInfluence.com Rankings
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Biology
Carla V. Rothlin's Degrees
- Bachelors Biology University of Buenos Aires
- PhD Immunology University of Buenos Aires
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Why Is Carla V. Rothlin Influential?
(Suggest an Edit or Addition)According to Wikipedia, Carla V. Rothlin is an Argentinian immunologist and Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology at Yale University in New Haven, Connecticut. Rothlin is also the co-leader of the Cancer Immunology Program at Yale Cancer Center as well as an Howard Hughes Medical Investigator faculty scholar. Rothlin studies the mechanisms that regulate immune homeostasis and wound repair, with specific interests in cell death recognition, immune checkpoints, and cellular crosstalk in the context of injury and cell turnover. She has made fundamental discoveries about the roles of TAM receptors tyrosine kinase and their ligands in the regulation of inflammation. Rothlin is also a co-founder of the Global Immunotalks, a weekly series of virtual Zoom lectures started in 2020 that brings together scientists from around the world to listen to cutting-edge immunology research from leaders in the field.
Carla V. Rothlin's Published Works
Published Works
- TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response (2007) (904)
- Immunobiology of the TAM receptors (2008) (718)
- α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells (2001) (681)
- TAM receptors regulate multiple features of microglial physiology (2016) (373)
- Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells (2017) (351)
- TAM receptor signaling in immune homeostasis. (2015) (314)
- A conserved dendritic-cell regulatory program limits antitumour immunity (2020) (287)
- Twist mediates suppression of inflammation by type I IFNs and Axl (2006) (249)
- TAM receptor function in the retinal pigment epithelium (2006) (237)
- A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart (2020) (221)
- Phagocytosis imprints heterogeneity in tissue-resident macrophages (2017) (194)
- Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. (2013) (181)
- TAM receptor signaling and autoimmune disease. (2010) (179)
- Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor (2000) (148)
- T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. (2013) (146)
- Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. (2006) (122)
- IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge. (2017) (122)
- Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo (2020) (121)
- TAM Receptors Are Not Required for Zika Virus Infection in Mice. (2017) (115)
- Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer (2013) (114)
- TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy (2017) (112)
- MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury (2017) (105)
- Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. (2019) (104)
- High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptor (2000) (102)
- The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation. (2016) (101)
- Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation. (2015) (95)
- The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors (1999) (93)
- Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage (2017) (93)
- MERTK as negative regulator of human T cell activation (2015) (78)
- The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity (2016) (70)
- Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor. (2000) (66)
- Direct Interaction of Serotonin Type 3 Receptor Ligands with Recombinant and Native α9α10-Containing Nicotinic Cholinergic Receptors (2003) (54)
- Heterogeneity in the initiation, development and function of type 2 immunity (2020) (52)
- Effects of Quinine, Quinidine, and Chloroquine on α9α10 Nicotinic Cholinergic Receptors (2005) (50)
- AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity (2016) (47)
- Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma (2014) (45)
- Stromal-cell regulation of natural killer cell differentiation (2007) (43)
- The alpha9 nicotinic acetylcholine receptor shares pharmacological properties with type A gamma-aminobutyric acid, glycine, and type 3 serotonin receptors. (1999) (40)
- Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation (2017) (38)
- Lifting the innate immune barriers to antitumor immunity (2020) (37)
- The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer (2017) (31)
- Tyro3, Axl, and Mertk Receptor Signaling in Inflammatory Bowel Disease and Colitis-associated Cancer (2014) (30)
- Direct interaction of serotonin type 3 receptor ligands with recombinant and native alpha 9 alpha 10-containing nicotinic cholinergic receptors. (2003) (30)
- Antiphospholipid Antibodies Inhibit Trophoblast Toll‐Like Receptor and Inflammasome Negative Regulators (2018) (30)
- Block of the α9 nicotinic receptor by ototoxic aminoglycosides (2000) (29)
- PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization (2018) (27)
- Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. (2021) (24)
- Determining the effector response to cell death (2020) (23)
- Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels (2021) (22)
- Death begets a new beginning (2017) (21)
- Negative Regulation of Type 2 Immunity. (2017) (20)
- Reinvigorating NIH Grant Peer Review. (2020) (15)
- Essential role of tuberous sclerosis genes TSC 1 and TSC 2 in NFk B activation and cell survival (12)
- Block of the alpha9 nicotinic receptor by ototoxic aminoglycosides. (2000) (10)
- Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors. (2005) (10)
- AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia (2021) (9)
- Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice (2021) (9)
- aPKC in neuronal differentiation, maturation and function (2019) (8)
- Nicotinic Cholinergic Receptors (2005) (8)
- The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver (2022) (6)
- Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages (2021) (5)
- Universal Principled Review: A Community-Driven Method to Improve Peer Review (2019) (5)
- Decoding Cell Death: From a Veritable Library of Babel to Vade Mecum? (2021) (5)
- Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity (2020) (5)
- GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection (2020) (5)
- Funerals and Feasts: The Immunological Rites of Cell Death (2019) (5)
- Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal (2017) (4)
- Management of cell death in parasitic infections (2021) (4)
- Induction of sterile type 2 inflammation (2019) (4)
- Tissue-specific modifier alleles determine Mertk loss-of-function traits (2022) (4)
- Axon Regeneration: Antagonistic Signaling Pairs in Neuronal Polarization. (2018) (3)
- Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. (2022) (3)
- Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa (2022) (2)
- Cell death in development, maintenance, and diseases of the nervous system (2022) (2)
- Coagulopathies and inflammatory diseases: '…glimpse of a Snark'. (2018) (2)
- Cracking the Cell Death Code. (2019) (2)
- Regulation of bone homeostasis by MERTK and TYRO3 (2022) (2)
- Regulation of chronic lung inflammation to house dust mite allergen by Wnt antagonist (CAM1P.144) (2015) (2)
- Efferocytosis fuels malignant pleural effusion through TIMP1 (2021) (1)
- Editorial overview: Innate immunity, from host defense and beyond. (2021) (1)
- IL-4-induced hysteresis in naïve T cell activation (2020) (1)
- Inhibition of renalase drives tumour rejection by promoting T cell activation. (2022) (1)
- Cenabis Bene: Treg Cells Invite Macrophages to Dine. (2018) (1)
- Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
- TLR9 dependent regulation of AXL expression impacts migration of autoreactive B cells (2020) (0)
- Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens. (2023) (0)
- Decision letter: CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation (2020) (0)
- 03.06 Mer-mediated efferocytosis tempers arthritis by preventing neutrophil littering in the joint (2017) (0)
- Serous macrophages pack Bhlhe40 for a randonnée (2019) (0)
- Abstract A092: TAM receptors targeting unleashes antileukemic immunity and enables checkpoint blockade leading to eradication of leukemic cells (2019) (0)
- Decision letter: CRISPR-based functional genomics in human dendritic cells (2021) (0)
- Decision letter: IFN-γ mediates Paneth cell death via suppression of mTOR (2020) (0)
- Decreased Levels of Circulatig Protein S in Patients with Active Crohn’s Disease (2017) (0)
- Author response: AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity (2016) (0)
- Abstract 1991: Axl overexpression drives migration and invasion in colon cancer (2014) (0)
- Prothrombotic Phenotype of a Protein S Mutant Lacking Anticoagulant Activity (2021) (0)
- P074 Decreased levels of circulating protein S (PROS1) in patients with active Crohn's disease. (2017) (0)
- TAMing Colitis and Colitis-Associated Colon Cancer: P-230 YI (2012) (0)
- DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain specific PKMζ. (2023) (0)
- Heterogeneity in the initiation, development and function of type 2 immunity (2020) (0)
- Abstract TP351: Axl/Mer Receptor Tyrosine Kinase Mediates Erythrophagocytosis-Induced Macrophage Reparative Phenotype and Brain Recovery in Experimental Intracerebral Hemorrhage (2017) (0)
- When aging gets on the way of disposal: Senescent cell suppression of efferocytosis. (2023) (0)
- Editor's evaluation: Functional visualization of NK cell-mediated killing of metastatic single tumor cells (2022) (0)
- Bringing on the itch (2019) (0)
- Decision letter: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis (2019) (0)
- P343 Levels of the anticoagulant and anti-inflammatory protein S (PROS1) in patients with inflammatory bowel disease (IBD) relationship with disease activity, IBD disease patterns, and C4-binding protein (C4BP) (2018) (0)
- A conserved dendritic-cell regulatory program limits antitumour immunity (2020) (0)
- Decision letter: Pioneer neutrophils release chromatin within in vivo swarms (2021) (0)
- P611 GAS6/AXL AXIS AS PROGNOSTIC AND THERAPEUTIC TARGET IN LIVER DISEASE (2014) (0)
- TAMing Colitis and Colitis‐Associated Colon Cancer: P‐230 YI (2012) (0)
- Role of the TAM receptor Axl in differentiation and activation of B cells (P4058) (2013) (0)
- Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity (2020) (0)
- Tu1815 - Levels of the Circulating Anticoagulant and Anti-inflammatory Protein S (PROS1) in Patients with Inflammatory Bowel Disease (IBD)-Relationship with Disease Activity, IBD Patterns and C4-Binding Protein (C4Bp) (2018) (0)
- Serous macrophages pack Bhlhe40 for a randonnée (2019) (0)
- T cell derived Protein S inhibits the activation of Dendritic cells through the TAM receptors Axl and Mer: O-26. (2011) (0)
- PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization (2018) (0)
- Science Signaling Podcast: 19 August 2014 (2014) (0)
- Abstract 1189: MERTK is a target in the microenviroenment of osteolytic bone metastasis (2023) (0)
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