Carl-Henrik Heldin
#41,872
Most Influential Person Now
Swedish biologist
Carl-Henrik Heldin's AcademicInfluence.com Rankings
Carl-Henrik Heldinbiology Degrees
Biology
#1358
World Rank
#2292
Historical Rank
Cell Biology
#28
World Rank
#32
Historical Rank
Molecular Biology
#100
World Rank
#103
Historical Rank
Neuroscience
#160
World Rank
#169
Historical Rank
Download Badge
Biology
Carl-Henrik Heldin's Degrees
- PhD Medical and Physiological Chemistry Uppsala University
Why Is Carl-Henrik Heldin Influential?
(Suggest an Edit or Addition)According to Wikipedia, Carl-Henrik Heldin is Chairman of the Board for the Nobel Foundation, and a molecular biologist and medical researcher. He has been director of the Uppsala branch of Ludwig Cancer Research since 1986 and professor in molecular cell biology at the medical faculty of Uppsala University since 1992. He is vice-president of the European Research Council since 2011 and was appointed chairman of the Nobel Foundation in 2013.
Carl-Henrik Heldin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- TGF-β signalling from cell membrane to nucleus through SMAD proteins (1997) (2786)
- Mechanism of action and in vivo role of platelet-derived growth factor. (1999) (2365)
- High interstitial fluid pressure — an obstacle in cancer therapy (2004) (1849)
- Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. (1994) (1734)
- Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling (1997) (1661)
- Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus (1983) (1466)
- TGF-beta signalling from cell membrane to nucleus through SMAD proteins. (1997) (1323)
- TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4 (1997) (1056)
- Non-Smad TGF-β signals (2005) (954)
- Smad regulation in TGF-beta signal transduction. (2001) (926)
- Signal transduction via platelet-derived growth factor receptors. (1998) (810)
- Specificity, diversity, and regulation in TGF‐β superfamily signaling (1999) (808)
- Growth factors: Mechanism of action and relation to oncogenes (1984) (795)
- Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression (2007) (793)
- Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. (1994) (749)
- Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. (1992) (733)
- Improvement of an "In-Gel" digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing. (1995) (730)
- Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor (1989) (719)
- cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines (1986) (715)
- Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. (1997) (709)
- Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor (1993) (696)
- Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. (1988) (655)
- The regulation of TGFβ signal transduction (2009) (621)
- Co‐localization of NG2 proteoglycan and PDGF α‐receptor on O2A progenitor cells in the developing rat brain (1996) (621)
- Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. (2009) (619)
- Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer* (1998) (609)
- TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. (2005) (593)
- Cloning and characterization of a human type II receptor for bone morphogenetic proteins. (1995) (569)
- Characterization of type I receptors for transforming growth factor-beta and activin. (1994) (564)
- The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner (2008) (543)
- Non-Smad TGF-beta signals. (2005) (541)
- Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects (1995) (536)
- Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. (2002) (530)
- Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor (1982) (508)
- Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. (2001) (477)
- A role of the latent TGF‐beta 1‐binding protein in the assembly and secretion of TGF‐beta 1. (1991) (476)
- Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. (2002) (469)
- Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein (1994) (466)
- PDGF receptors as cancer drug targets. (2003) (462)
- Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. (1988) (453)
- TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. (1999) (441)
- Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition (2006) (437)
- The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation (1998) (429)
- TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences (1990) (427)
- Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. (2002) (414)
- PDGF-C is a new protease-activated ligand for the PDGF α-receptor (2000) (411)
- Platelet-derived growth factor: mechanism of action and possible in vivo function. (1990) (410)
- Targeting the PDGF signaling pathway in tumor treatment (2013) (409)
- Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling* (1997) (408)
- Regulation of EMT by TGFβ in cancer (2012) (408)
- Signaling Receptors for TGF-β Family Members. (2016) (384)
- Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia. (1981) (382)
- Inhibitory DNA ligands to platelet-derived growth factor B-chain. (1996) (377)
- Platelet-derived growth factor: purification and partial characterization. (1979) (369)
- A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains (1986) (368)
- Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members. (1998) (367)
- PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor (2001) (363)
- Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. (1993) (362)
- Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. (1988) (357)
- Signaling inputs converge on nuclear effectors in TGF-β signaling (2000) (352)
- Control of Smad7 stability by competition between acetylation and ubiquitination. (2002) (351)
- PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. (2000) (350)
- cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. (1989) (348)
- HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition* (2008) (348)
- Identification of two juxtamembrane autophosphorylation sites in the PDGF beta‐receptor; involvement in the interaction with Src family tyrosine kinases. (1993) (343)
- Id2 and Id3 Define the Potency of Cell Proliferation and Differentiation Responses to Transforming Growth Factor β and Bone Morphogenetic Protein (2004) (338)
- Activation of the human c‐kit product by ligand‐induced dimerization mediates circular actin reorganization and chemotaxis. (1991) (329)
- Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta. (1994) (325)
- PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. (2001) (314)
- Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase. (1994) (313)
- Purification and properties of an endothelial cell growth factor from human platelets. (1987) (305)
- The c‐sis gene encodes a precursor of the B chain of platelet‐derived growth factor. (1984) (303)
- Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. (1998) (302)
- Specificity, diversity, and regulation in TGF-beta superfamily signaling. (1999) (301)
- Platelet-derived growth factor is angiogenic in vivo. (1992) (299)
- cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules (1988) (292)
- Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth (1985) (292)
- Role of Smads in TGFβ signaling (2011) (290)
- The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. (1999) (283)
- Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. (2001) (283)
- A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse (2008) (282)
- Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. (1988) (281)
- Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. (1989) (280)
- Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. (1994) (279)
- Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes. (1990) (267)
- Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7* (1998) (259)
- PDZ domains bind carboxy-terminal sequences of target proteins. (1996) (258)
- INDUCTION OF B-TYPE RECEPTORS FOR PLATELET-DERIVED GROWTH FACTOR IN VASCULAR INFLAMMATION: POSSIBLE IMPLICATIONS FOR DEVELOPMENT OF VASCULAR PROLIFERATIVE LESIONS (1988) (257)
- Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. (1996) (257)
- Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. (1986) (254)
- Transforming growth factor-beta: latent forms, binding proteins and receptors. (1993) (251)
- PDGF and vessel maturation. (2010) (250)
- A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain. (1988) (250)
- Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells (1993) (242)
- Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. (1993) (242)
- Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas. (1996) (241)
- Interaction between NG2 proteoglycan and PDGF α‐receptor on O2A progenitor cells is required for optimal response to PDGF (1996) (241)
- New members of the platelet-derived growth factor family of mitogens. (2002) (238)
- PDGF A chain homodimers drive proliferation of bipotential (O‐2A) glial progenitor cells in the developing rat optic nerve. (1989) (234)
- Platelet-derived growth factor: identification of constituent polypeptide chains. (1982) (232)
- PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage. (1989) (231)
- Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses* (2003) (230)
- Role for carbohydrate structures inTGF-β1 latency (1989) (229)
- Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation (1984) (227)
- Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. (2009) (227)
- Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein. (1985) (224)
- Smad regulation in TGF-β signal transduction (223)
- A glioma-derived PDGF a chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets (1988) (220)
- Involvement of platelet-derived growth factor in disease: development of specific antagonists. (2001) (217)
- PDGF receptors as targets in tumor treatment. (2007) (212)
- Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3 (2003) (211)
- Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF. (1991) (211)
- Possible positive autocrine feedback in the prereplicative phase of human fibroblasts (1987) (207)
- Platelet‐derived growth factor in human glioma (1995) (207)
- Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras (1994) (201)
- Degradation of the Tumor Suppressor Smad4 by WW and HECT Domain Ubiquitin Ligases* (2005) (200)
- Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads (2001) (200)
- Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling. (1999) (199)
- ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif (2011) (198)
- Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate. (2004) (197)
- Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner (1988) (196)
- Regulation of Smad signaling by protein kinase C (2001) (192)
- Identification of two C‐terminal autophosphorylation sites in the PDGF beta‐receptor: involvement in the interaction with phospholipase C‐gamma. (1992) (190)
- Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. (1992) (190)
- Nomenclature: Vertebrate Mediators of TGFβ Family Signals (1996) (189)
- Platelet-derived growth factor. Isolation by a large-scale procedure and analysis of subunit composition. (1981) (183)
- Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway* (1997) (182)
- VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. (2008) (182)
- Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis (2010) (181)
- TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer (2011) (180)
- Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor. (1982) (180)
- Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition (2016) (180)
- Interaction of platelet-derived growth factor with its fibroblast receptor. Demonstration of ligand degradation and receptor modulation. (1982) (178)
- Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus (1985) (177)
- Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner. (2001) (175)
- Transforming Growth Factor-β Signaling (2013) (174)
- Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. (1991) (174)
- Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. (1994) (173)
- Receptors for transforming growth factor-beta. (1994) (171)
- Platelet-derived growth factor: three isoforms and two receptor types. (1989) (171)
- Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. (1988) (168)
- Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease. (1993) (165)
- The Balance between Acetylation and Deacetylation Controls Smad7 Stability* (2005) (165)
- Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes. (1992) (164)
- Chemical and biological properties of a growth factor from human‐cultured osteosarcoma cells: Resemblance with platelet‐derived growth factor (1980) (162)
- Efficient TGF-β Induction of the Smad7 Gene Requires Cooperation between AP-1, Sp1, and Smad Proteins on the Mouse Smad7 Promoter* (2000) (162)
- Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor (1991) (161)
- Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. (2005) (160)
- Isoform‐specific induction of actin reorganization by platelet‐derived growth factor suggests that the functionally active receptor is a dimer. (1989) (159)
- Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor. (1988) (158)
- STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake. (2003) (157)
- Direct interaction between Shc and the platelet-derived growth factor beta-receptor. (1994) (157)
- Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines. (1987) (156)
- Mechanisms of platelet‐derived growth factor–induced chemotaxis (2001) (156)
- Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes* (2000) (155)
- Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor. (1992) (154)
- B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase. (1990) (153)
- Induction of epithelial-mesenchymal transition by transforming growth factor β. (2012) (153)
- Rat brain capillary endothelial cells express functional PDGF B-type receptors. (1989) (151)
- Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. (1993) (151)
- Nuclear Factor YY1 Inhibits Transforming Growth Factor β- and Bone Morphogenetic Protein-Induced Cell Differentiation (2003) (150)
- Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor. (1986) (150)
- Platelet-derived growth factor (1985) (150)
- Physical and Functional Interaction of Murine andXenopus Smad7 with Bone Morphogenetic Protein Receptors and Transforming Growth Factor-β Receptors* (1998) (146)
- Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom (2009) (145)
- Smad7 mediates apoptosis induced by transforming growth factor β in prostatic carcinoma cells (2000) (144)
- Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases (2004) (142)
- Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 alpha and transforming growth factor-beta 1. (1992) (142)
- Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein. (1986) (140)
- TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α (2017) (138)
- Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C. (1995) (137)
- Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation. (1989) (137)
- Identification and structural analysis of the A type receptor for platelet-derived growth factor. Similarities with the B type receptor. (1989) (135)
- Interactions of recombinant and platelet transforming growth factor-beta 1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor. (1989) (135)
- Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. (1997) (135)
- Mutation of a Src phosphorylation site in the PDGF beta‐receptor leads to increased PDGF‐stimulated chemotaxis but decreased mitogenesis. (1996) (134)
- A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity. (1984) (134)
- Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation. (2001) (133)
- Enhanced expression of transforming growth factor‐β and its type‐I and type‐II receptors in human glioblastoma (1995) (132)
- Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope. (1998) (132)
- Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain. (1991) (130)
- Suppressors of T-cell Receptor Signaling Sts-1 and Sts-2 Bind to Cbl and Inhibit Endocytosis of Receptor Tyrosine Kinases* (2004) (129)
- PARP-1 attenuates Smad-mediated transcription. (2010) (128)
- Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. (2002) (127)
- Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing (1988) (127)
- Effect of epidermal growth factor on membrane motility and cell locomotion in cultures of human clonal glioma cells (1982) (127)
- Expression of Smad proteins in human colorectal cancer (1999) (126)
- A Novel GTPase-activating Protein for Rho Interacts with a PDZ Domain of the Protein-tyrosine Phosphatase PTPL1* (1997) (125)
- Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. (2007) (125)
- Involvement of phosphatidylinositide 3'-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. (1997) (124)
- Signaling inputs converge on nuclear effectors in TGF-beta signaling. (2000) (124)
- Platelet-derived Growth Factor Stimulates Membrane Lipid Synthesis Through Activation of Phosphatidylinositol 3-Kinase and Sterol Regulatory Element-binding Proteins* (2004) (124)
- Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation (1994) (121)
- Expression of platelet-derived growth factor and its receptors in neuroendocrine tumors of the digestive system. (1992) (120)
- Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis (1995) (120)
- Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration. (1999) (119)
- Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells. (1977) (119)
- Smad pathway‐specific transcriptional regulation of the cell cycle inhibitor p21WAF1/Cip1 (2005) (119)
- TGF-beta signaling from receptors to Smads (2008) (118)
- Growth factors as transforming proteins. (1989) (117)
- Structural and functional properties of platelet-derived growth factor and stem cell factor receptors. (2013) (117)
- Cultured human endothelial cells express platelet-derived growth factor A chain. (1987) (116)
- The DNA Binding Activities of Smad2 and Smad3 Are Regulated by Coactivator-mediated Acetylation* (2006) (115)
- Notch signaling is necessary for epithelial growth arrest by TGF-β (2007) (114)
- TGF-beta signaling by Smad proteins. (2000) (112)
- The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination* (2010) (111)
- Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C. (1993) (110)
- Dynamic control of TGF‐β signaling and its links to the cytoskeleton (2008) (110)
- Role of Platelet-Derived Growth Factor in Vivo (1988) (109)
- Regulation of Transcription Factor Twist Expression by the DNA Architectural Protein High Mobility Group A2 during Epithelial-to-Mesenchymal Transition* (2012) (108)
- Interaction between Smad7 and β-Catenin: Importance for Transforming Growth Factor β-Induced Apoptosis (2005) (108)
- Functional proteomics of transforming growth factor‐β1‐stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFβ1‐dependent regulation of DNA repair (2002) (108)
- Differential Ubiquitination Defines the Functional Status of the Tumor Suppressor Smad4* (2003) (107)
- The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling (2000) (107)
- Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C. (1994) (106)
- Site-Selective Regulation of Platelet-Derived Growth Factor β Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase (2004) (106)
- Phosphorylation of Ser165 in TGF‐beta type I receptor modulates TGF‐beta1‐induced cellular responses. (1996) (104)
- Activated platelet‐derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line (1994) (103)
- Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities. (1989) (103)
- Use of an antiserum against phosphotyrosine for the identification of phosphorylated components in human fibroblasts stimulated by platelet-derived growth factor. (1984) (103)
- Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin. (1992) (103)
- The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran (2006) (102)
- Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer (2010) (102)
- Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. (1994) (101)
- Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis. (2000) (100)
- Synthesis of a PDGF-like growth factor in human glioma and sarcoma cells suggests the expression of the cellular homologue to the transforming protein of simian sarcoma virus. (1983) (99)
- Identification of the Major Phosphorylation Sites for Protein Kinase C in Kit/Stem Cell Factor Receptor in Vitro and in Intact Cells (*) (1995) (99)
- Clonal variation in the production of a platelet-derived growth factor-like protein and expression of corresponding receptors in a human malignant glioma. (1986) (98)
- Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. (2003) (98)
- TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. (1990) (98)
- Characterization of an imatinib-sensitive subset of high-grade human glioma cultures (2006) (97)
- Platelet-derived growth factor in autocrine transformation. (1991) (96)
- Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling. (1993) (96)
- Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human culturei endothelial and glial cells. (1977) (96)
- Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form. (1992) (96)
- Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase. (1983) (96)
- Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor- Binding Protein with the Extracellular Matrix (*) (1995) (96)
- Expression of Platelet‐Derived Growth Factor Receptors is Induced on Connective Tissue Cells During Chronic Synovial Inflammation (1988) (95)
- Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF β-receptor juxtamembrane and kinase insert domains (1998) (95)
- Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion (2013) (95)
- Ligand-induced dimerization of growth factor receptors: variations on the theme. (1996) (94)
- Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4 (2000) (93)
- Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis. (1994) (93)
- Expression of Platelet-Derived Growth Factor (PDGF) and PDGF α- and β-Receptors in the Peripheral Nervous System: An Analysis of Sciatic Nerve and Dorsal Root Ganglia (1993) (93)
- Induction of transforming growth factor-beta during cardiac allograft rejection. (1993) (93)
- Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. (1994) (93)
- Intimal Hyperplasia Recurs After Removal of PDGF-AB and -BB Inhibition in the Rat Carotid Artery Injury Model (2000) (91)
- From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction. (2002) (91)
- Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer. (1988) (90)
- TGFβ induces SIK to negatively regulate type I receptor kinase signaling (2008) (90)
- SHP-2 binds to Tyr763 and Tyr1009 in the PDGF β-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis (1999) (90)
- Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses (2006) (89)
- Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line. (1988) (88)
- Simultaneous induction of stimulatory and inhibitory signals by PDGF (1997) (87)
- Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth. (1993) (87)
- Signals and Receptors. (2016) (86)
- Characterization of a platelet endoglycosidase degrading heparin-like polysaccharides. (1980) (86)
- Serine/threonine kinase receptors. (1994) (85)
- Subversion of growth regulatory pathways in malignant transformation. (1987) (85)
- Signal transduction by the receptors for platelet-derived growth factor. (1990) (84)
- Intracellular signaling of osteogenic protein‐1 through Smad5 activation (1998) (84)
- TGF-β type I receptor / ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells (1999) (83)
- PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly (1992) (83)
- A Human Keratinocyte Cell Line Produces Two Autocrine Growth Inhibitors, Transforming Growth Factor-β and Insulin-like Growth Factor Binding Protein-6, in a Calcium- and Cell Density-dependent Manner (*) (1995) (83)
- Latent forms of TGF-beta: molecular structure and mechanisms of activation. (1991) (82)
- Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines (1987) (81)
- Demonstration of an antibody against platelet-derived growth factor. (1981) (80)
- Expression of platelet-derived growth factor beta-receptors on stromal tissue cells in human carcinoid tumors. (1990) (80)
- Grb7 is a Downstream Signaling Component of Platelet-derived Growth Factor α- and β-Receptors* (1996) (80)
- 2R and remodeling of vertebrate signal transduction engine (2010) (78)
- Protein tyrosine kinase receptors. (1996) (78)
- Similar action of platelet‐derived growth factor and epidermal growth factor in the prereplicative phase of human fibroblasts suggests a common intracellular pathway (1985) (77)
- The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling. (2000) (77)
- A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet-derived growth factor. (1988) (76)
- Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation* (2009) (76)
- Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. (2005) (76)
- Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44* (2006) (75)
- Developmental regulation of mammary-derived growth inhibitor expression in bovine mammary tissue (1990) (75)
- Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways. (2000) (75)
- PDGF induces reorganization of vimentin filaments. (1998) (74)
- Expression of transforming growth factors beta 1, beta 2, beta 3 in neuroendocrine tumors of the digestive system. (1994) (73)
- Nomenclature: vertebrate mediators of TGFbeta family signals. (1996) (73)
- Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification (2015) (73)
- Surface binding and internalization of platelet-derived growth factor in human fibroblasts. (1983) (72)
- Expression of transforming‐growth‐factor (TGF)‐β receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF‐β1 (1999) (72)
- Characterization of platelet-derived growth factor beta-receptor expressing cells in the vasculature of human rheumatoid synovium. (1991) (72)
- Recombinant Latent Transforming Growth Factor β-binding Protein 2 Assembles to Fibroblast Extracellular Matrix and Is Susceptible to Proteolytic Processing and Release* (1998) (71)
- Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line (1998) (71)
- Induction of platelet‐derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines. (1987) (70)
- Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling (2007) (69)
- Different Effects of High and Low Shear Stress on Platelet-Derived Growth Factor Isoform Release by Endothelial Cells: Consequences for Smooth Muscle Cell Migration (2002) (69)
- Demonstration of stimulatory effects of platelet-derived growth factor on cultivated rat arterial smooth muscle cells. Differences between cells from young and adult animals. (1983) (68)
- Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis (2018) (68)
- TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1 (2014) (68)
- Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors. (1998) (66)
- Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes. (1991) (66)
- Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells (2006) (66)
- JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion (2017) (66)
- Autocrine PDGF stimulation in malignancies (2012) (65)
- Snail depletes the tumorigenic potential of glioblastoma (2013) (65)
- Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction. (1994) (64)
- Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c‐myc messenger RNA and inhibition of 3H‐thymidine incorporation in human fibroblasts (1989) (64)
- Tamoxifen Inhibits TGF‐β‐Mediated Activation of Myofibroblasts by Blocking Non‐Smad Signaling Through ERK1/2 (2015) (63)
- Effects of homodimeric isoforms of platelet-derived growth factor (PDGF-AA and PDGF-BB) on wound healing in rat. (1992) (63)
- Effect of transforming growth factor‐β and platelet‐derived growth factor‐BB on articular cartilage in rats (1996) (63)
- Expression of multiple growth factors in a human lung cancer cell line (1987) (62)
- Immunoglobulin-like Domain 4-mediated Receptor-Receptor Interactions Contribute to Platelet-derived Growth Factor-induced Receptor Dimerization* (1997) (62)
- Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects (1988) (62)
- Growth of normal human glial cells in a defined medium containing platelet-derived growth factor. (1980) (61)
- p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity* (2000) (61)
- A PLATELET‐DERIVED GROWTH FACTOR ANALOG PRODUCED BY A HUMAN CLONAL GLIOMA CELL LINE * (1982) (61)
- Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts. (1986) (61)
- Structural Determinants in the Platelet-derived Growth Factor -Receptor Implicated in Modulation of Chemotaxis (*) (1996) (60)
- Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene (1991) (60)
- TGFβ1-Induced Activation of ATM and p53 Mediates Apoptosis in a Smad7-Dependent Manner (2006) (59)
- In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma. (2007) (59)
- Characterization of the retention motif in the C-terminal part of the long splice form of platelet-derived growth factor A-chain. (1994) (59)
- Expression of PDGF A-chain and beta-receptor genes during rat myoblast differentiation (1990) (59)
- Role for carbohydrate structures in TGF-beta 1 latency. (1989) (59)
- Production of platelet-derived endothelial cell growth factor by normal and transformed human cells in culture. (1989) (58)
- Autoinhibition of the Platelet-derived Growth Factor β-Receptor Tyrosine Kinase by Its C-terminal Tail* (2004) (58)
- Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor. (1988) (57)
- Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1* (2010) (57)
- The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition (2014) (57)
- TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1 (2014) (57)
- Phosphorylation of Smad7 at Ser-249 Does Not Interfere with Its Inhibitory Role in Transforming Growth Factor-β-dependent Signaling but Affects Smad7-dependent Transcriptional Activation* (2001) (57)
- BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors (2016) (57)
- Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling. (2009) (57)
- Demonstration of Functionally Different Interactions between Phospholipase C-γ and the Two Types of Platelet-derived Growth Factor Receptors (*) (1995) (57)
- Platelet-derived Growth Factor β-Receptor, Transforming Growth Factor β Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability* (2014) (56)
- Phosphorylation of Ser165 in TGF‐β type I receptor modulates TGF‐β1‐induced cellular responses (1996) (55)
- Density-dependent inhibition of cell growth by transforming growth factor-beta 1 in normal human fibroblasts. (1988) (54)
- Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli* (2011) (54)
- Identification of Tyr-762 in the platelet-derived growth factor α-receptor as the binding site for Crk proteins (1998) (54)
- Differential expression of platelet-derived growth factor α- and β-receptors on fat-storing cells and endothelial cells of rat liver (1991) (54)
- Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product. (1985) (54)
- Oral Imatinib Mesylate (STI571/Gleevec) Improves the Efficacy of Local Intravascular Vascular Endothelial Growth Factor-C Gene Transfer in Reducing Neointimal Growth in Hypercholesterolemic Rabbits (2004) (54)
- Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase. (2002) (54)
- Effects of platelet-derived growth factor and somatomedin-C/insulin-like growth factor I on the deoxyribonucleic acid replication of fetal rat islets of Langerhans in tissue culture. (1988) (53)
- Alix Facilitates the Interaction between c-Cbl and Platelet-derived Growth Factor β-Receptor and Thereby Modulates Receptor Down-regulation* (2006) (52)
- Growth factors induce early pre‐replicative changes in senescent human fibroblasts. (1986) (52)
- A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex. (1994) (52)
- Signal transduction via serine/threonine kinase receptors. (1994) (51)
- Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A- or B-chain cDNA: retention of PDGF-BB in the endoplasmic reticulum and Golgi complex. (1990) (51)
- Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases (2014) (51)
- Purification of the receptor for platelet-derived growth factor from porcine uterus. (1987) (51)
- Growth factors and oncogenes in human malignant glioma. (1985) (51)
- Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases. (2000) (50)
- Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42 (2004) (50)
- The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB (2017) (50)
- SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor (2002) (50)
- Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V (2012) (50)
- Characterization of the Interactions between PDZ Domains of the Protein-tyrosine Phosphatase PTPL1 and the Carboxyl-terminal Tail of Fas* (1997) (50)
- PDGF‐like growth factors in autocrine stimulation of growth (1987) (50)
- Cultured Kaposi's sarcoma-derived cells express functional PDGF A-type and B-type receptors. (1990) (49)
- Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma (2009) (49)
- Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant (1993) (49)
- Expression of PDGF alpha- and beta-receptors in rat arterial smooth muscle cells is phenotype and growth state dependent. (1990) (49)
- The effect of platelet-derived growth factor on morphology and motility of human glial cells (1983) (48)
- Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release. (1997) (48)
- Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth (2018) (48)
- Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. (2003) (48)
- Expression of TGF-beta related Smad proteins in human epithelial skin tumors. (1999) (48)
- The GS domain of the transforming growth factor-beta type I receptor is important in signal transduction. (1995) (48)
- High-yield purification of platelet-derived endothelial cell growth factor: structural characterization and establishment of a specific antiserum. (1989) (48)
- SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55γ Published, JLR Papers in Press, April 23, 2007. (2007) (48)
- Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB. (1991) (48)
- Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription. (2005) (48)
- Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. (1992) (47)
- Platelet-derived growth factors: A family of isoforms that bind to two disticnt receptors (1989) (47)
- A decisive function of transforming growth factor-β/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes (2011) (47)
- Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis. (2010) (47)
- Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor (1985) (46)
- Loss of T-Cell Protein Tyrosine Phosphatase Induces Recycling of the Platelet-derived Growth Factor (PDGF) β-Receptor but Not the PDGF α-Receptor (2006) (46)
- Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro. (2010) (45)
- Regulation of chemotaxis by the cytoplasmic domain of tissue factor (2004) (45)
- The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling. (2000) (45)
- Functional antagonism between activin and osteogenic protein‐1 in human embryonal carcinoma cells (1999) (45)
- Identification of a peptide antagonist for platelet-derived growth factor. (1992) (45)
- Latent Forms of TGF‐β: Structure and Biology (1990) (45)
- Overactivation of Phospholipase C-γ1 Renders Platelet-derived Growth Factor β-Receptor-expressing Cells Independent of the Phosphatidylinositol 3-Kinase Pathway for Chemotaxis* (1999) (44)
- Growth factors and their receptors. (1989) (44)
- Pool of ligand‐bound platelet‐derived growth factor β‐receptors remain activated and tyrosine phosphorylated after internalization (1993) (44)
- A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis. (1994) (44)
- TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage. (2005) (44)
- Increased mitogenicity of an αβ heterodimeric PDGF receptor complex correlates with lack of RasGAP binding (1999) (43)
- Structure of platelet-derived growth factor: implications for functional properties. (1993) (43)
- Involvement of PDGF ligands and receptors in tumorigenesis (2017) (43)
- Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor. (1981) (43)
- p53 regulates epithelial–mesenchymal transition induced by transforming growth factor β (2013) (43)
- Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction (1990) (42)
- Characterization of the chronic myelomonocytic leukemia associated TEL-PDGFβR fusion protein (1999) (42)
- Signal Transduction: Multiple Pathways, Multiple Options for Therapy (2001) (42)
- Structural and functional aspects of the receptors for platelet-derived growth factor. (1989) (42)
- Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types. (1992) (42)
- Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours. (1996) (42)
- Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis. (1990) (41)
- PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells. (1998) (41)
- Ecsit-ement on the crossroads of Toll and BMP signal transduction. (2003) (41)
- Filamin a mediates HGF/c‐MET signaling in tumor cell migration (2011) (40)
- SH2 domains: elements that control protein interactions during signal transduction. (1991) (40)
- The phenotypic characteristics of simian sarcoma virus‐transformed human fibroblasts suggest that the v‐sis gene product acts solely as a PDGF receptor agonist in cell transformation. (1986) (40)
- Gab1 Contributes to Cytoskeletal Reorganization and Chemotaxis in Response to Platelet-derived Growth Factor* (2004) (40)
- TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness (2020) (39)
- Functional role of Meox2 during the epithelial cytostatic response to TGF‐β (2007) (39)
- Smad Signal Transduction (2006) (39)
- Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D (2013) (38)
- Identification of three amino acids in the platelet-derived growth factor (PDGF) B-chain that are important for binding to the PDGF beta-receptor. (1991) (38)
- Compartmentalization of Autocrine Signal Transduction Pathways in Sis-transformed NIH 3T3 Cells (*) (1995) (38)
- Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases. (2001) (38)
- Intracellular trafficking of transforming growth factor &bgr; receptors (2018) (38)
- Nck Adapters Are Involved in the Formation of Dorsal Ruffles, Cell Migration, and Rho Signaling Downstream of the Platelet-derived Growth Factor β Receptor* (2008) (38)
- c-Jun N-terminal Kinase Is Necessary for Platelet-derived Growth Factor-mediated Chemotaxis in Primary Fibroblasts* (2006) (37)
- Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts. (1989) (36)
- Dynamin Inhibitors Impair Endocytosis and Mitogenic Signaling of PDGF (2013) (36)
- Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells (2018) (36)
- Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization. (2000) (35)
- Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells (1992) (35)
- Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors. (2020) (35)
- Transcriptional Induction of Salt-inducible Kinase 1 by Transforming Growth Factor β Leads to Negative Regulation of Type I Receptor Signaling in Cooperation with the Smurf2 Ubiquitin Ligase* (2012) (35)
- TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor (2015) (35)
- Density‐dependent inhibitory effect of transforming growth factor‐β on human fibroblasts involves the down‐regulation of platelet‐derived growth factor α‐receptors (1993) (34)
- Intercellular Variation in Signaling through the TGF-β Pathway and Its Relation to Cell Density and Cell Cycle Phase* (2012) (34)
- Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis. (1991) (34)
- Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer. (2019) (34)
- Localization of platelet-derived endothelial cell growth factor in human placenta and purification of an alternatively processed form. (1990) (34)
- RIPping Tyrosine Kinase Receptors Apart (2001) (34)
- TGFβ1/Smad3 counteracts BRCA1-dependent repair of DNA damage (2005) (33)
- APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration (2012) (33)
- Platelet-derived endothelial cell growth factor. (1990) (33)
- Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160. (1997) (32)
- Desensitisation of cultured glial cells to epidermal growth factor by receptor down-regulation (1979) (32)
- Platelet-derived growth factor and autocrine mechanisms of oncogenic processes. (1991) (32)
- Characterization of a 60‐kDa cell surface‐associated transforming growth factor‐β binding protein that can interfere with transforming growth factor‐β receptor binding (1997) (32)
- Effects of epidermal growth factor and platelet-derived growth factor on c-fos and c-myc mRNA levels in normal human fibroblasts. (1987) (32)
- BRCA2 and Smad3 synergize in regulation of gene transcription (2002) (32)
- TGF-beta signaling from a three-dimensional perspective: insight into selection of partners. (2002) (32)
- Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor. (2006) (32)
- Activation of growth factor receptors in esophageal cancer--implications for therapy. (2007) (31)
- Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes. (1992) (31)
- Platelet-derived growth factor--an introduction. (2004) (31)
- Platelet-derived growth factor (PDGF)-induced actin rearrangement is deregulated in cells expressing a mutant Y778F PDGF beta-receptor. (1998) (30)
- Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program (2016) (30)
- Expression of platelet-derived growth factor (PDGF) and PDGF alpha- and beta-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia. (1993) (30)
- Platelet‐derived endothelial cell growth factor (1991) (30)
- Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cells (2018) (30)
- Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42. (2004) (30)
- Transforming Growth Factor (TGF-β)-specific Signaling by Chimeric TGF-β Type II Receptor with Intracellular Domain of Activin Type IIB Receptor* (1997) (29)
- Development and possible clinical use of antagonists for PDGF and TGF-β (2004) (29)
- Differential expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human lung carcinoma cell lines. (1993) (29)
- Transforming Growth Factor β Promotes Complexes between Smad Proteins and the CCCTC-binding Factor on the H19 Imprinting Control Region Chromatin* (2010) (29)
- The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo* (2013) (29)
- TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling (2018) (29)
- Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors. (1989) (29)
- Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors. (1989) (28)
- Expression of transforming-growth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-beta1. (1999) (28)
- Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression (2020) (28)
- Biosynthesis and intracellular transport of the receptor for platelet-derived growth factor. (1987) (28)
- Expression of messenger RNAs for platelet‐derived growth factor and its receptors in human sarcoma cell lines (1990) (28)
- A Gain of Function Mutation in the Activation Loop of Plateletderived Growth Factor β-Receptor Deregulates Its Kinase Activity* (2004) (28)
- Involvement of loop 2 of platelet-derived growth factor-AA and -BB in receptor binding. (1995) (27)
- Expression of platelet-derived growth factor-beta receptors on human fibroblasts. Regulation by recombinant platelet-derived growth factor-BB, IL-1, and tumor necrosis factor-alpha. (1992) (27)
- Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma (2017) (27)
- Involvement of hyaluronan and CD44 in cancer and viral infections. (2019) (27)
- Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding. (1999) (27)
- The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling* (2016) (27)
- LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation (2019) (27)
- TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells. (2009) (27)
- Covalent linkage between nucleotides and platelet-derived endothelial cell growth factor. (1991) (26)
- The Expression of PDGF α- and β-Receptors in Subpopulations of PDGF-Producing Cells Implicates Autocrine Stimulatory Loops in the Control of Proliferation in Cytotrophoblasts that Have Invaded the Maternal Endometrium (1992) (26)
- Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis (2020) (26)
- PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation. (1997) (26)
- An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta. (2007) (25)
- Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner (2010) (25)
- Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation. (2015) (25)
- Structural and functional aspects of platelet-derived growth factor. (1988) (25)
- High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity (2019) (24)
- APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain (2015) (24)
- The platelet-derived growth factor receptor (1988) (24)
- A Rat Pituitary Tumor Cell Line (GH) Expresses Type I and Type II Receptors and Other Cell Surface Binding Protein(s) for Transforming Growth Factor- (*) (1995) (23)
- Role of Immunoglobulin-like Domains 2–4 of the Platelet-derived Growth Factor α-Receptor in Ligand-Receptor Complex Assembly* (1998) (23)
- A new twist in Smad signaling. (2006) (23)
- Ca2+ binding of latent transforming growth factor‐β1 binding protein (1993) (23)
- [Functions of the transforming growth factor-beta superfamily in eyes]. (1997) (22)
- Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor. (1983) (22)
- Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells (2018) (22)
- COULD PLATELET-DERIVED GROWTH FACTOR HAVE A ROLE IN THE PATHOGENESIS OF LUPUS NEPHRITIS? (1988) (22)
- Bone morphogenetic protein-7 (OP1) and transforming growth factor-beta1 modulate 1,25(OH)2-vitamin D3-induced differentiation of human osteoblasts. (2002) (22)
- Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation. (2011) (21)
- Platelet-derived growth factor receptor-β, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma (2007) (21)
- Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling (2014) (21)
- Platelet-derived growth factor (PDGF) in neoplastic and non-neoplastic cystic lesions of the central nervous system and in the cerebrospinal fluid. (1994) (21)
- The gene expression profile of PDGF-treated neural stem cells corresponds to partially differentiated neurons and glia (2006) (21)
- Differential expression of platelet-derived growth factor alpha- and beta- receptors on fat-storing cells and endothelial cells of rat liver. (1991) (20)
- Characterization of in vivo phosphorylation of activin type II receptor. (1993) (20)
- Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes. (1999) (20)
- Identification of a 190-kDa Vascular Endothelial Growth Factor 165 Cell Surface Binding Protein on a Human Glioma Cell Line* (1997) (19)
- Structure, Function and Possible Clinical Application of Transforming Growth Factor‐β (1992) (19)
- The PI 3-kinase isoforms p 110 α and p 110 β have differential roles in PDGF-and insulin-mediated signaling (2000) (18)
- CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface (2015) (18)
- Specific cleavage of the fibroblast receptor for platelet-derived growth factor by an endogenous Ca2+-dependent thiol protease. (1986) (18)
- PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element–modifying factor 1 (2018) (17)
- Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration. (2010) (17)
- The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity (2019) (17)
- The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension (2019) (17)
- Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13. (1992) (17)
- A gain-of-function mutation in the PDGFR-β alters the kinetics of injury response in liver and skin (2008) (17)
- Tissue distribution of macrophages, class II transplantation antigens, and receptors for platelet-derived growth factor in normal and rejected human kidneys. (1987) (17)
- Transforming growth factor-beta and organ transplantation. (1993) (17)
- Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in cancer (2017) (16)
- NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar (2014) (16)
- Smad signal transduction : Smads in proliferation, differentiation and disease (2006) (16)
- Platelet‐derived endothelial cell growth factor Pharmacokinetics, organ distribution and degradation after intravenous administration in rats (1992) (16)
- Assignment of intrachain disulfide bonds in platelet-derived growth factor B-chain. (1993) (15)
- Regulation of fibroblast-mediated collagen gel contraction by platelet- derived growth factor, interleukin-1 a and transforming growth factor-/^ (2005) (15)
- Differences in binding to the solid substratum and extracellular matrix may explain isoform-specific paracrine effects of platelet-derived growth factor. (1994) (15)
- Highly Active Antiretroviral Therapy Attenuates Re-Endothelialization and Alters Neointima Formation in the Rat Carotid Artery After Balloon Injury (2006) (15)
- The expression of PDGF alpha- and beta-receptors in subpopulations of PDGF-producing cells implicates autocrine stimulatory loops in the control of proliferation in cytotrophoblasts that have invaded the maternal endometrium. (1992) (14)
- EBV‐inducing factor from platelets exhibits growth‐promoting activity for NIH 3T3 cells. (1985) (14)
- Differential effects of PDGF isoforms on proliferation of normal rat kidney cells. (1993) (14)
- Transduction of circular membrane ruffling by the platelet-derived growth factor beta-receptor is dependent on its kinase insert. (1992) (14)
- Ligand Stimulation Reduces Platelet-derived Growth Factor β-Receptor Susceptibility to Tyrosine Dephosphorylation* (2001) (14)
- The dephosphorylation characteristics of the receptors for epidermal growth factor and platelet‐derived growth factor in Swiss 3T3 cell membranes suggest differential regulation of receptor signalling by endogenous protein‐tyrosine phosphatases (1993) (14)
- Structural and functional aspects of platelet-derived growth factor and its role in the pathogenesis of glioblastoma. (1989) (14)
- Structural and functional aspects of platelet-derived growth factor and its receptors. (1990) (14)
- Latent forms of TGF-beta: structure and biology. (1990) (14)
- The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity. (2011) (14)
- SMAD destruction turns off signalling (1999) (13)
- Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling. (2016) (13)
- TGF-b promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85a (2017) (13)
- Signal transduction: An anchor for activation (1999) (13)
- Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells. (1994) (13)
- Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output (2019) (12)
- Ligand-induced homo- and hetero-dimerization of platelet-derived growth factor alpha- and beta-receptors in intact cells. (1992) (12)
- BMP signaling is a therapeutic target in ovarian cancer (2020) (11)
- Platelet-derived growth factor (PDGF)-induced actin rearrangement is deregulated in cells expressing a mutant Y778F PDGF β-receptor (1998) (11)
- The nuts and bolts of IRF structure (2003) (11)
- Commercially Available Preparations of Recombinant Wnt3a Contain Non‐Wnt Related Activities Which May Activate TGF‐β Signaling (2016) (11)
- The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling (2015) (11)
- Effect of transforming growth factor-β on calcium homeostasis in prostate carcinoma cells (2003) (11)
- Expression of Platelet-Derived Growth Factor in and around Intrastriatal Embryonic Mesencephalic Grafts (1993) (11)
- Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells (2020) (11)
- The protein kinase SIK downregulates the polarity protein Par3 (2015) (11)
- Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation (2016) (10)
- Transforming growth factor-β employs HMGA 2 to elicit epithelial – mesenchymal transition (2006) (10)
- A B-type PDGF receptor lacking most of the intracellular domain escapes degradation after ligand binding. (1989) (10)
- The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response. (1989) (10)
- MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis. (2012) (10)
- Coordination of TGF-β signaling by ubiquitylation. (2013) (10)
- Combination therapy using imatinib and vatalanib improves the therapeutic efficiency of paclitaxel towards a mouse melanoma tumor (2011) (10)
- Hydrocortisone-induced increase of PDGF beta-receptor expression in a human malignant mesothelioma cell line. (1992) (10)
- Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells. (2003) (9)
- Tumor Promoting Effect of BMP Signaling in Endometrial Cancer (2021) (9)
- JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses (2019) (9)
- Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma (2017) (9)
- Platelet-derived growth factor as a mediator of normal and neoplastic cell proliferation (1986) (9)
- Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer (2022) (9)
- Phosphorylation of a 72‐kDa protein in PDGF‐stimulated cells which forms complex with c‐Crk, c‐Fyn and Eps15 (1997) (8)
- Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency. (2000) (8)
- Bone Morphogenetic Proteins and their Receptors (2006) (8)
- Deletion of Exon I of SMAD 7 in Mice Results in Altered B Cell Responses (2006) (8)
- Density-dependent inhibitory effect of transforming growth factor-beta 1 on human fibroblasts involves the down-regulation of platelet-derived growth factor alpha-receptors. (1993) (8)
- Expression of the c-sis gene and secretion of a platelet-derived growth factor-like protein by simian virus 40-transformed BHK cells. (1985) (8)
- Bone morphogenetic protein receptors. (1996) (8)
- Purification, cloning, and expression of platelet-derived endothelial cell growth factor. (1991) (7)
- Structure, function and possible clinical application of transforming growth factor-beta. (1992) (7)
- Growth factor receptors in cell transformation (1997) (7)
- Gab 1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor (2004) (7)
- The Smad family (2006) (7)
- MEK is a negative regulator of Stat5b in PDGF‐stimulated cells (1999) (7)
- Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor. (1997) (7)
- Stimulation of tyrosine phosphorylation by platelet-derived growth factor. (1984) (6)
- Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice. (2004) (6)
- Nucleosome regulatory dynamics in response to TGFβ (2014) (6)
- Structure and function of platelet-derived growth factor. (2009) (6)
- Association of coatomer proteins with the beta-receptor for platelet-derived growth factor. (1997) (6)
- Smad2 Phosphorylation by Type I Receptor (2004) (6)
- Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation* (2016) (6)
- Transforming growth factor-β and organ transplantation (1993) (6)
- Role of PDGF-Like Growth Factors in Autocrine Stimulation of Growth of Normal and Transformed Cells (1986) (6)
- Feedback Control: The role of negative feedback in signal transduction control (2008) (5)
- Identification of three amino acid residues in the B-chain of platelet-derived growth factor with different importance for binding to PDGF alpha- and beta-receptors. (1996) (5)
- Upsala Journal of Medical Sciences (2015) (5)
- The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling (2021) (5)
- The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma (2021) (5)
- Eccrine sweat glands: expression of transforming growth factor-beta and bone morphogenetic protein type I receptors and their intracellular signalling Smad proteins. (1999) (5)
- Protein Tyrosine Kinase Receptor Signaling Overview (2010) (5)
- TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation (2021) (5)
- Identification of three amino acid residues in the B‐chain of platelet‐derived growth factor with different importance for binding to PDGF α‐ and β‐receptors (1996) (5)
- BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells. (2021) (5)
- Platelet-derived growth factor ( PDGF )-induced activation of signal transducer and activator of transcription ( Stat ) 5 is mediated by PDGF β-receptor and is not dependent on cSrc , Fyn , Jak 1 or Jak 2 kinases (5)
- 9 TGF-β Signaling from Receptors to Smads (2008) (5)
- Biological Properties of Simian Sarcoma Virus and Its Oncogene Product (1987) (5)
- Autocrine Stimulation of Growth of Normal and Transformed Cells (1990) (5)
- The PDGFR Receptor Family (2015) (5)
- Possible in vivo effect and clinical utility of platelet-derived growth factor and PDGF antagonists. (1993) (4)
- Tumors and an Associated Increase in Tumor Growth Rate Melanoma Cells Leads to Increased Pericyte Abundance in Platelet-Derived Growth Factor Production by B 16 Updated (2004) (4)
- The European Research Council — a new opportunity for European science (2008) (4)
- Retention of PDGFR- (cid:1) function in mice in the absence of phosphatidylinositol 3 (cid:1) -kinase and phospholipase C (cid:2) signaling pathways (2000) (4)
- The mechanism of action of transforming growth factor-β (1993) (4)
- [Transforming growth factor-beta. An interesting candidate for clinical use]. (1995) (4)
- Foreword : Transforming Growth Factor-beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (2008) (4)
- Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B. (2019) (4)
- Cloning and expression of human platelet-derived growth factor α and β receptors (1991) (4)
- Mini-Review Transforming Growth Factor-P: Latent Forms, Binding Proteins and Receptors (1993) (4)
- TRAF6 promotes TGFb-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFb type I receptor (2015) (4)
- TGF- (cid:1) and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition □ D (2005) (4)
- Signal transduction mechanisms for members of the TGF-β family (2001) (3)
- [30] Purification of platelet-derived growth factor β receptor from porcine uterus (1991) (3)
- Ca2+ binding of latent transforming growth factor-beta 1 binding protein. (1993) (3)
- Induction of Platelet-derived Growth Factor a- and &Receptor mRNA and Protein by Platelet-derived Growth Factor BB* (2001) (3)
- Interaction of Platelet-derived Growth Factor with Its Fibroblast Receptor OF LIGAND DEGRADATION AND RECEPTOR MODULATION* (2011) (3)
- PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A (2021) (3)
- Stimulation of endothelial cell proliferation by a factor released from human platelets. (1977) (3)
- TGFβ selects for pro‐stemness over pro‐invasive phenotypes during cancer cell epithelial–mesenchymal transition (2022) (2)
- EFFECT OF A PLAFEXET ENDOGLYCOSIDASE @'J CELL SURFACE ASSOCIATEDHEPARAN SULFHAT'F OFHUMAN CULTUREDENWTHELI~ AND GLIAL CELLS (1977) (2)
- Characterization of the fibroblast receptor for platelet-derived growth factor (1983) (2)
- Combination of VEGF-C gene transfer and treatment with the PDGF receptor kinase inhibitor STI571 leads to persistent reduction in neointima formation in balloon-denunded rabbit aorta (2002) (2)
- Cloning and expression of human platelet-derived growth factor alpha and beta receptors. (1991) (2)
- Targeting the PDGF signaling pathway in tumor (2013) (2)
- Purification of human platelet-derived growth factor. (1987) (2)
- Signal Transduction: Overview (2002) (2)
- The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in (2000) (2)
- Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner. (2019) (2)
- The TGFβ superfamily in Lisbon: navigating through development and disease (2017) (2)
- Characterization of the platelet-derived growth factor beta-receptor kinase activity by use of synthetic peptides. (1990) (2)
- Transforming Growth Factor-β Receptors and Signal Transduction (1997) (2)
- Growth factors: In vivo function and mechanism of action (1993) (2)
- The high mobility group A 2 protein epigenetically silences the Cdh 1 gene during epithelial-to-mesenchymal transition (2015) (2)
- Platelet-Derived Growth Factor: Structure, Function, and Role in Autocrine Stimulation of Growth (1986) (2)
- [Platelet-derived growth factor in normal and malignant cell growth]. (1984) (2)
- Platelet-derived growth factor (PDGF) B-chain gene expression by activated blood monocytes precedes the expression of the PDGF A-chain gene (1987) (2)
- Structural andfunctional aspects ofplatelet-derived growth factor* (1988) (1)
- Platelet-Derived Growth Factor: : Normal Function, Role in Disease, and Application of PDGF Antagonists (2005) (1)
- Role of PDGF-like growth factors in autocrine stimulation of cell growth (1987) (1)
- Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling (2022) (1)
- CHAPTER 69 – Protein Tyrosine Kinase Receptor Signaling Overview (2003) (1)
- Oncogenes, Growth Factors and the Pathogenesis of Human Glioma: The 1986 Engelhardt Lecture (1987) (1)
- Platelet-derived growth factor ( PDGF )-induced actin rearrangement is deregulated in cells expressing a mutant Y 778 F PDGF β-receptor (1997) (1)
- 8 7 A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse Gerli (2008) (1)
- Growth regulatory proteins from human platelets. (1989) (1)
- Pancreas Cancer Molecular Targets for Therapy (2011) (1)
- Smad7 Enhances TGFβ-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells (2020) (1)
- High Levels of Serum Hyaluronan Predicts Severe Dengue Infection and Perturbs Vascular Integrity (2019) (1)
- From mono- to oligo-Smads: The heart of the matter in TGF- (cid:1) signal transduction (2002) (1)
- The type II TGF-β receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling (2022) (1)
- Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival (2023) (1)
- Targeting the PDGF signaling pathway in tumor treatment (2013) (1)
- Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D (2013) (1)
- Towards improved cancer diagnosis and treatment founded on current developments in the basic sciences: options for intensified European efforts. An EORTC Research Branch Scientific Advisory Board Consensus Paper. (1991) (1)
- Role of PDGF in Tumor-Stroma Interactions (2011) (1)
- The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma (2021) (1)
- PtdIns 3-kinase (2011) (1)
- Autoinhibition of the PDGF β -receptor tyrosine kinase by its C-terminal tail (1)
- Review Growth factors as transforming proteins (1989) (1)
- Identification of receptors and Smad proteins involved in activin signals in human epidermal keratinocytes (1998) (1)
- PARP-2 activation and association with Smads during regulation of TGFβ signaling (2012) (0)
- Epithelial-to-Mesenchymal Transition Expression during Induction of HMGA 2 and Smads Co-regulate SNAIL 1 Developmental (2008) (0)
- Pro-invasive Snail1 targets TGFbeta receptor I to promote epithelial to mesenchymal transition in prostate cancer (2015) (0)
- LXRα limits the pro-fibrotic action of TGFβ in liver cancer-associated fibroblasts (2017) (0)
- SIK and Smurf2 cooperate to downregulate the TGF-β type I receptor (2010) (0)
- Mechanism of platelet-derived growth factor (PDGF) Erk5 MAP-kinase activation is cell type-dependent and can be independent of PDGF receptor kinase activity (2015) (0)
- CTCF and Smad Proteins of the TGF-β Pathway interact during regulation of gene expression from the H19 imprinted control region (2008) (0)
- SIGNAL TRANSDUCTION VIA RECEPTORS FOR PDGF AND TGF‐β‐POSSIBLE TARGETS IN TUMOR THERAPY (2007) (0)
- Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells (2022) (0)
- satisfying for someone who has followed the field since its start, to witness the remarkable progress that has been made. (2004) (0)
- Identification of Lys178 as the acceptor lysine of TGF-beta type I receptor poly-ubiquitination. (2014) (0)
- Binding ofdifferent dimeric formsofPDGFtohuman fibroblasts: evidence fortwo separatereceptor types (1988) (0)
- Different Dimeric Forms of PDGF have Different Functional Activities (1988) (0)
- Activin receptor-like kinases, proteins having serine / threonine kinase domains and their applications (1993) (0)
- Patent Number : 5 , 756 , 686 45 ) Date of Patent : May 26 , 1998 (2017) (0)
- The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial‐mesenchymal transition (2023) (0)
- Inhibition of TGF-β/Smad signaling pathway during epithelial to mesenchymal transition by vanadium. (2015) (0)
- Table of Contents (1984) (0)
- Depletion of DUSP4 results in enhanced PDGFRβ cell surface clearance and suppression of PDGF-BB-induced activation of Erk5, Stat3, Src and PKC (2016) (0)
- DNA encoding platelet derived endothelial cell growth factor (PD-ECGF) (1994) (0)
- Structural and Functional Aspects of Plateletderived Growth Factor and its Receptors (1990) (0)
- IBiosynthesis and intracellular transport of the receptor for platelet-derived growth factor (2003) (0)
- The ubiquitin-specific protease 4 de-ubiquitinates and stabilizes PDGF receptor β (2019) (0)
- CD44 and Hyal2 affect capillary endothelial cell differentiation and breast cancer transmigration (2013) (0)
- Antagonist STI 571 through Induction of Apoptosis Tumors by the Platelet-derived Growth Factor Receptor Growth Inhibition of Dermatofibrosarcoma Protuberans (2001) (0)
- Direct Interaction between Shc and the Platelet-derived Growth Factor PReceptor " (2001) (0)
- Role of Smads in TGFβ signaling (2011) (0)
- Primary Cancer Site (2011) (0)
- Examination of the structure and biosynthesis of the human PDGF receptor (1987) (0)
- Tyr-716 inthePlatelet-Derived GrowthFactor3-Receptor Kinase Insert IsInvolved inGRB2Binding andRasActivation (1994) (0)
- Stromal effects of PDGFR inhibition by STI571 in experimental carcinoma: Altered collagen fibrils and reduction of a specific stromal cell population (2010) (0)
- Abstract 1982: TGF-beta induced SIK cooperates with Smurf2 to negatively regulate type I receptor kinase signaling (2011) (0)
- The use of phosphotyrosine-peptides for the determination of the specificity of SHC-protein binding to PDGF β-receptor (1995) (0)
- Par3 promotes glioblastoma stem cell self-renewal while inhibiting cell invasion (2017) (0)
- The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ (2023) (0)
- Dissociation ofMitogen-activate d (1996) (0)
- Table of Contents (1993) (0)
- Role of Dicer in Breast Cancer Stem Cells (2014) (0)
- TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses (2018) (0)
- Platelet-derived growth factor — Structural and functional aspects of the A-chain gene (1989) (0)
- Substantially pure receptor-like, TGF-beta-1-binding molecules and their uses (1992) (0)
- Development and applications of PDGF antagonists (1998) (0)
- Luteal failure in transgenic mice carrying a PDGF dominant-negative mutant/GH hybrid transgene (1995) (0)
- Mechanisms for induction of hyaluronan synthesis and CD44 expression in human skin fibroblasts by PDGF-BB (2005) (0)
- TGFβ promotes prostate cancer cell migration via TRAF6-mediated ubiquitination of p85α causing activation of the PI3K/AKT pathway. (2016) (0)
- The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells (2022) (0)
- Rox, a novel bHLHZip protein expressed in Reconstitution of the protein insertion machinery of the mitochondrial inner quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a membrane transcriptional repressor (2013) (0)
- Purification of platelet-derived growth factor beta receptor from porcine uterus. (1991) (0)
- 21 Meet the ERC (2012) (0)
- Analysis of gene expression in neural stem cells during proliferation and differentiation (2004) (0)
- Issue Information (2022) (0)
- Tokuda Akihiro Tomida Shinya Toyokuni Hitoshi Tsuda Shoichiro Tsugane Tatsuhiko Tsunoda Heiichiro Udono Koji Ueda Yoshimasa Uehara Hiroo Ueno Kazuo Umezawa Toshikazu Ushijima Toshihiko Wakabayashi Kenji Wakai Tetsuro Watabe (2016) (0)
- Loss of T-Cell Protein Tyrosine Phosphatase Induces Recycling of the Platelet-derived Growth Factor (PDGF) (cid:1) -Receptor but Not the PDGF (cid:2) -Receptor □ D (2006) (0)
- Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases (2013) (0)
- VEFG-B Inhibits Oxidative Stress, Serum Deprivation, and Bmf Induced Apoptosis in Cultured Cells (2008) (0)
- Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells (2022) (0)
- Ligand-Induced Horno- and Hetero-Dirnerization of Platelet-Derived Growth Factor a- and PReceptors in (1992) (0)
- Advisory Board and Contents (2020) (0)
- Studies on growth factors for human cultured cells (1980) (0)
- TGFβ promotes cancer cell migration via TRAF6-specific ubiquitination of p85α causing activation of the PI3K/AKT pathway (2015) (0)
- Pure Platelet-Derived Growth Factor Stimulates Human Fibroblasts to Proliferate in Plasma-Free Culture (1983) (0)
- Expression of the csis oncogene in early human placenta : implications for possible autocrine or paracrine control of cytotrophoblast proliferation (2008) (0)
- Large, complex latent TGF-beta2 and TGF-beta3 (1993) (0)
- Isolation byalarge-scale procedure andanalysis ofsubunit composition (1981) (0)
- TGFβ-mediated transcription is regulated by PARP-1/PARG-balanced ADP-ribosylation (2010) (0)
- The non-coding MIR100HG RNA mediates cytostatic responses of epithelial cells to transforming growth factor β (2018) (0)
- PDGF: Isoform-specific signalling via receptor dimers (1990) (0)
- Late abstracts PL . 2 COMT Val 108 / 158 Met polymorphism and its association with overweight and obesity in Polish population (2011) (0)
- Abstract P5 October 2: Signal transduction and gene regulationActivation of P13-kinase is required for platelet derived growth factor-mediated chemotaxis (1994) (0)
- BMP signaling is a therapeutic target in ovarian cancer (2020) (0)
- I-SMAD recruits type I receptor phosphatase and ubiquitin ligases to mediate receptor downregulation (2006) (0)
- Role of Platelet-Derived Growth Factor in Autocrine and Paracrine Stimulation of Normal and Malignant Cells (2019) (0)
- SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition (2011) (0)
- Regulation of novel gene targets of TGFβ signaling by PARP-1 (2012) (0)
- Specific targeting of PDGFRβ inhibits growth and angiogenesis in tumors with high PDGF-BB expression (2019) (0)
- Cloning,. andcharacterization ofahumantypeIIreceptor forbone morphogenetic proteins (1995) (0)
- Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression: Erratum (2020) (0)
- Cell regulation: Cellular signaling (2007) (0)
- Platelet-Derived Growth Factor : Structural and Functional Aspects (1983) (0)
- Platelet-derived growthfactor: Purification andpartial characterization (sodium dodecyl sulfate gelelectrophoresis/hydrophobic (1979) (0)
- Uses of platelet-derived growth factor-d, encoding it and their dns (1999) (0)
- Platelet-derived growth factor B type receptor (1990) (0)
- Tony Pawson 1952–2013 (2013) (0)
- TGFb type I receptor and endosomal APPL regulate AURKB during mitosis and cytokinesis (2016) (0)
- 89 Gene expression profiling of cancer associated fibroblasts (2004) (0)
- D growth factor, platelet derived DNA encoding the same and their uses. (1999) (0)
- Recombinant Production of A-chain polypeptides of PDGF (1988) (0)
- Signal transduction mechanisms for members of the TGF-beta superfamily (2001) (0)
- Thematic issue on platelet-derived growth factor (2004) (0)
- Smad7 and APC are required for EGF-induced cell migration in human prostate epithelial cells (2011) (0)
- TGFβ engages TRAF6 and p38 to regulate c-Jun activity and invasion of prostate cancer cells. (2014) (0)
- Parg, proteine d'activation de gtpase exerçant une interaction avec ptpl1 (1998) (0)
- Population Candidate Gene Association Study (2011) (0)
- Platelet-derived growth factor : Purification and partial characterization ( sodium dodecyl sulfate gel electrophoresis / hydrophobic chromatography / radioiodination / cultured cells ) (0)
- Erk5 promotes prolonged PDGFRβ activation by limiting ligand-induced receptor internalization and degradation (2016) (0)
- Neuroprotection of Vegf-b by Inhibition of Apoptosis (2008) (0)
- Platelet-derived growth factor: comments on the structural and functional relationship with the transforming protein of simian sarcoma virus (1985) (0)
- Iodine-labelled growth factors in biochemical research-PDGF and its receptor (1988) (0)
- Platelet-derived Growth Factor and its Role in Mitogenesis and Transformation (1989) (0)
- Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma (2017) (0)
- Advisory Board and Contents (2021) (0)
- Expression ofPlatelet-derived Growth Factor andItsReceptors inProliferative Disorders ofFibroblastic Origin (1992) (0)
- Tyrosine kinases, receptor-linked - platelet-derived growth factor receptors (2006) (0)
- Ratskeletal myoblasts andarterial smooth muscle cells express the genefortheAchain butnotthegenefortheB chain (c-sis) of platelet-derived growth factor (PDGF)andproduce a PDGF-like protein (autocrine stimuladon/cell growth/differentiation/protooncogenes) (1986) (0)
- HD-PTP is important for platelet-derived growth factor beta-receptor downregulation and mitogenicity (2010) (0)
- Growthofnormalhumanglial cells inadefined mediumcontaining platelet-derived growth factor (cell multiplication/serum-free conditions/MCDB 105medium/miniclones) (1980) (0)
- Molecular Oncology: Platelet-derived growth factor (2013) (0)
- Growth factor regulation of kinases. (2001) (0)
- Receptor Serine/Threonine Kinases (2006) (0)
- Different forms of PDGF-like molecules: Possible role in autocrine growth stimulation (1987) (0)
- Abstract B64: The role of deubiquitinating enzyme USP17, hyaluronan synthase 2, and hyaluronan in non-small-cell lung cancer oncogenic transformation (2018) (0)
- 363 Targeting of PDGF receptors; combination effects in various solid tumors and identification of a PDGF dependent brain tumor subset (2004) (0)
- CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence (2022) (0)
- The Fer tyrosine kinase is necessary for platelet-derived growth factor-BB-induced Stat3 phosphorylation and colony formation in soft agar (2010) (0)
- VEGF-B Inhibits the Expression of Apoptotic/Cell Death-Related Genes in Multiple Types of Cells (2008) (0)
- Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product ( simian sarcoma virus-transformed cells / receptor competition assay / tyrosine phosphorylation / autocrine stimulation ) (0)
- The protein kinase LKB1 takes oncogenic actions in glioblastoma promoting self-renewal and invasiveness (2017) (0)
- Ligand-stimulation reduces PDGF β-receptor susceptibility to tyrosine dephosphorylation (2001) (0)
- Endothelial cell growth factor, as well as process for the purification thereof (1989) (0)
- Mutation ofProline-1003 toGlycine intheEpidermal GrowthFactor (EGF) Receptor Enhances Responsiveness toEGF (1994) (0)
- Expression of platelet-derived growth factor in and around intrastriatal embryonic mesencephalic grafts. (1993) (0)
- Other Publications by the Author Activation and Asso- Ciation with Smads during Regulation of Tgf Tgf-β Signaling. Man- Uscript (0)
- The receptors for transforming growth factor β (TGFβ) and platelet derived growth factor-BB (PDGF-BB) interact physically and functionally with CD44 (2013) (0)
- Transfonning Growth Factor-fi Receptors and Signal Transduction (1997) (0)
- [Growth factors--clarification of their mechanism]. (1995) (0)
- [A new series: growth factors]. (1995) (0)
- Platelet-derived growth factor (PDGF) (2003) (0)
- TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling (2018) (0)
- Organization andChromosomal Localization oftheHumanPlatelet- Derived Endothelial CellGrowthFactor Gene (1991) (0)
This paper list is powered by the following services:
Other Resources About Carl-Henrik Heldin
What Schools Are Affiliated With Carl-Henrik Heldin?
Carl-Henrik Heldin is affiliated with the following schools:
