Carol E. Cass
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(Suggest an Edit or Addition)Carol E. Cass's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The equilibrative nucleoside transporter family, SLC29 (2004) (716)
- Gastric Adenocarcinoma: Review and Considerations for Future Directions (2005) (714)
- Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. (1998) (574)
- Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. (2009) (419)
- Cloning of a human nucleoside transporter implicated in the Cellular uptake of adenosine and chemotherapeutic drugs (1997) (413)
- The Absence of Human Equilibrative Nucleoside Transporter 1 Is Associated with Reduced Survival in Patients With Gemcitabine-Treated Pancreas Adenocarcinoma (2004) (395)
- Nucleoside transporters: molecular biology and implications for therapeutic development. (1999) (352)
- Molecular Identification and Characterization of Novel Human and Mouse Concentrative Na+-Nucleoside Cotransporter Proteins (hCNT3 and mCNT3) Broadly Selective for Purine and Pyrimidine Nucleosides (System cib)* (2001) (326)
- Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium (2013) (304)
- Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy† (2003) (300)
- Nucleoside transporters: from scavengers to novel therapeutic targets. (2006) (292)
- Functional Characterization of Novel Human and Mouse Equilibrative Nucleoside Transporters (hENT3 and mENT3) Located in Intracellular Membranes* (2005) (289)
- The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. (2013) (279)
- Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. (1997) (261)
- Transport of nucleoside drugs in animal cells. (1981) (234)
- Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). (1997) (232)
- Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. (1999) (227)
- Molecular Cloning and Functional Characterization of Nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) Equilibrative Nucleoside Transporter Proteins (rENT1 and rENT2) from Rat Tissues* (1997) (227)
- The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs (2007) (226)
- Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma. (2012) (223)
- The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms (2001) (219)
- The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. (2005) (217)
- Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. (1994) (213)
- Human Equilibrative Nucleoside Transporter 1 and Human Concentrative Nucleoside Transporter 3 Predict Survival after Adjuvant Gemcitabine Therapy in Resected Pancreatic Adenocarcinoma (2009) (205)
- Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. (1998) (189)
- Mediated transport of nucleosides in human erythrocytes. Specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane. (1974) (183)
- Distribution and Functional Characterization of Equilibrative Nucleoside Transporter-4, a Novel Cardiac Adenosine Transporter Activated at Acidic pH (2006) (177)
- Molecular biology of nucleoside transporters and their distributions and functions in the brain. (2011) (153)
- Nucleoside transporters of mammalian cells. (1999) (148)
- Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. (2001) (145)
- Nucleoside transport and its significance for anticancer drug resistance. (1998) (143)
- Functional and Molecular Characterization of Nucleobase Transport by Recombinant Human and Rat Equilibrative Nucleoside Transporters 1 and 2 (2002) (140)
- Association of DNA Repair and Steroid Metabolism Gene Polymorphisms with Clinical Late Toxicity in Patients Treated with Conformal Radiotherapy for Prostate Cancer (2006) (140)
- Topology of a Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter (hENT1) Implicated in the Cellular Uptake of Adenosine and Anti-cancer Drugs* (2001) (137)
- Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). (2001) (130)
- Mutation of Residue 33 of Human Equilibrative Nucleoside Transporters 1 and 2 Alters Sensitivity to Inhibition of Transport by Dilazep and Dipyridamole* (2002) (128)
- Mediated transport of nucleosides in human erythrocytes. Accelerative exchange diffusion of uridine and thymidine and specificity toward pyrimidine nucleosides as permeants. (1972) (126)
- Recent advances in the molecular biology of nucleoside transporters of mammalian cells. (1998) (125)
- Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins. (2008) (125)
- A common basis for inhibition of nucleoside transport by dipyridamole and nitrobenzylthioinosine? (1980) (120)
- Chimeric Constructs between Human and Rat Equilibrative Nucleoside Transporters (hENT1 and rENT1) Reveal hENT1 Structural Domains Interacting with Coronary Vasoactive Drugs* (1998) (117)
- Lymphovascular Invasion Is Associated With Poor Survival in Gastric Cancer: An Application of Gene-Expression and Tissue Array Techniques (2006) (114)
- Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system (2001) (114)
- Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy. (2000) (109)
- Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q). (1999) (107)
- Distribution of Equilibrative, Nitrobenzylthioinosine‐Sensitive Nucleoside Transporters (ENT1) in Brain (1999) (102)
- Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins (2008) (101)
- Nucleobase Transport by Human Equilibrative Nucleoside Transporter 1 (hENT1)* (2011) (101)
- Subcellular Distribution and Membrane Topology of the Mammalian Concentrative Na+-Nucleoside Cotransporter rCNT1* (2001) (100)
- A Comparison of the Transportability, and Its Role in Cytotoxicity, of Clofarabine, Cladribine, and Fludarabine by Recombinant Human Nucleoside Transporters Produced in Three Model Expression Systems (2006) (94)
- Electrophysiological characterization of a recombinant human Na+‐coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes (2004) (93)
- Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers. (2002) (90)
- Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. (2001) (89)
- Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. (2008) (89)
- Absence of binding sites for the transport inhibitor nitrobenzylthioinosine on nucleoside transport-deficient mouse lymphoma cells. (1981) (88)
- Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes. (2002) (85)
- Molecular identification of the equilibrative NBMPR-sensitive (es) nucleoside transporter and demonstration of an equilibrative NBMPR-insensitive (ei) transport activity in human erythroleukemia (K562) cells (1997) (83)
- Identification of Amino Acid Residues Responsible for the Pyrimidine and Purine Nucleoside Specificities of Human Concentrative Na+ Nucleoside Cotransporters hCNT1 and hCNT2* (1999) (83)
- Functional expression of Na(+)-dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis. Demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second, novel system N3 having broad specificity for purine and pyrimidine nucleosides. (1993) (80)
- Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations. (2005) (80)
- The Role of Human Nucleoside Transporters in Uptake of 3′-Deoxy-3′-fluorothymidine (2008) (78)
- Nucleoside Transporter Proteins of Saccharomyces cerevisiae (2000) (78)
- The Broadly Selective Human Na+/Nucleoside Cotransporter (hCNT3) Exhibits Novel Cation-coupled Nucleoside Transport Characteristics* (2005) (77)
- Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes. (1996) (76)
- Multidrug transporter p‐glycoprotein 170 as a differentiation antigen on normal human lymphocytes and thymocytes: Modulation with differentiation stage and during aging (1995) (76)
- Recent advances in the molecular biology of nucleoside transporters of mammalian cells (1998) (75)
- Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. (1979) (75)
- Enhancement of 9-beta-d-arabinofuranosyladenine cytotoxicity to mouse leukemia L1210 in vitro by 2'-deoxycoformycin. (1976) (75)
- Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells (2005) (72)
- Differential activity of vincristine and vinblastine against cultured cells. (1984) (69)
- Demonstration of the existence of mRNAs encoding N1/cif and N2/cit sodium/nucleoside cotransporters in rat brain. (1996) (69)
- Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells. (1996) (69)
- Distribution of mRNA encoding a nitrobenzylthioinosine-insensitive nucleoside transporter (ENT2) in rat brain. (1999) (68)
- The role of membrane transporters in cellular resistance to anticancer nucleoside drugs. (2002) (67)
- Gastric Cancer: Establishing Predictors of Biologic Behavior with Use of Population-Based Data (2004) (66)
- Nitric Oxide and Cyclic GMP Increase the Expression of Matrix Metalloproteinase-9 in Vascular Smooth Muscle (2003) (66)
- Transport of the antiviral nucleoside analogs 3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes. (1996) (66)
- Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA. (2004) (65)
- cN-II expression predicts survival in patients receiving gemcitabine for advanced non-small cell lung cancer. (2005) (65)
- Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae. (2003) (65)
- Mediated transport of nucleosides by human erythrocytes. Specificity toward purine nucleosides as permeants. (1973) (64)
- Effect of duration of exposure to verapamil on vincristine activity against multidrug-resistant human leukemic cell lines. (1989) (64)
- Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomes. (1999) (61)
- Identification of a Novel Membrane Transporter Associated with Intracellular Membranes by Phenotypic Complementation in the Yeast Saccharomyces cerevisiae(*) (1996) (60)
- Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma (2010) (60)
- Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1 (2003) (59)
- Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells. (2001) (59)
- Demonstration of Equilibrative Nucleoside Transporters (hENT1 and hENT2) in Nuclear Envelopes of Cultured Human Choriocarcinoma (BeWo) Cells by Functional Reconstitution in Proteoliposomes* (1998) (59)
- Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine. (2008) (59)
- Biodistribution and Uptake of 3′-Deoxy-3′-Fluorothymidine in ENT1-Knockout Mice and in an ENT1-Knockdown Tumor Model (2010) (59)
- Equilibrative nucleoside transporters: mapping regions of interaction for the substrate analogue nitrobenzylthioinosine (NBMPR) using rat chimeric proteins. (2001) (57)
- Differential Transport of Cytosine-Containing Nucleosides by Recombinant Human Concentrative Nucleoside Transporter Protein hCNT1 (2000) (55)
- Localization of broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney. (2007) (54)
- Binding of nitrobenzylthioinosine to high-affinity sites on the nucleoside-transport mechanism of HeLa cells. (1981) (54)
- Assessing SNP-SNP Interactions among DNA Repair, Modification and Metabolism Related Pathway Genes in Breast Cancer Susceptibility (2013) (54)
- Inhibition of Nucleoside Transport (1983) (52)
- TRANSPORT OF NUCLEOSIDES * (1975) (52)
- XRCC1 Stimulates Polynucleotide Kinase by Enhancing Its Damage Discrimination and Displacement from DNA Repair Intermediates* (2007) (52)
- Uridine Recognition Motifs of Human Equilibrative Nucleoside Transporters 1 and 2 Produced in Saccharomyces cerevisiae (2004) (52)
- Initial rate kinetics of the transport of adenosine and 4-amino-7-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (tubercidin) in cultured cells. (1982) (51)
- Inhibitory effects of propentofylline on [3H]adenosine influx. A study of three nucleoside transport systems. (1993) (51)
- Inhibition by nitrobenzylthioinosine of adenosine uptake by asynchronous HeLa cells. (1977) (50)
- Fluctuations in nucleoside uptake and binding of the inhibitor of nucleoside transport, nitrobenzylthioinosine, during the replication cycle of HeLa cells. (1979) (50)
- Renal nucleoside transporters: physiological and clinical implications. (2006) (50)
- Inward fluxes of adenosine in erythrocytes and cultured cells measured by a quenched-flow method. (1984) (49)
- Low specificity of the nucleoside transport mechanism of RPMI 6410 cells. (1979) (48)
- Role of Human Nucleoside Transporters in the Uptake and Cytotoxicity of Azacitidine and Decitabine (2012) (48)
- Expression of high levels of nitrobenzylthioinosine-sensitive nucleoside transport in cultured human choriocarcinoma (BeWo) cells. (1992) (46)
- Regulation of K(+) current in human airway epithelial cells by exogenous and autocrine adenosine. (2001) (46)
- The kinetics of dissociation of the inhibitor of nucleoside transport, nitrobenzylthioinosine, from the high-affinity binding sites of cultured hamster cells. (1983) (46)
- Germline copy number variations are associated with breast cancer risk and prognosis (2017) (45)
- Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae. (2002) (45)
- Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC). (2011) (45)
- Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility (2011) (44)
- Identification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2. (2001) (44)
- Nucleoside transport as a potential target for chemotherapy in malaria. (2007) (42)
- Purine Uptake and Release in Rat C6 Glioma Cells (2000) (41)
- Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer (2010) (41)
- Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. (2004) (40)
- Uridine Binding and Transportability Determinants of Human Concentrative Nucleoside Transporters (2005) (40)
- Nitrobenzylthionionosine binding sites in the erythrocyte membrane. (1976) (40)
- A comparison of the abilities of nitrobenzylthioinosine, dilazep, and dipyridamole to protect human hematopoietic cells from 7-deazaadenosine (tubercidin). (1992) (40)
- Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer. (2007) (39)
- Residues 334 and 338 in Transmembrane Segment 8 of Human Equilibrative Nucleoside Transporter 1 Are Important Determinants of Inhibitor Sensitivity, Protein Folding, and Catalytic Turnover* (2007) (39)
- Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3 (2007) (38)
- Residue 33 of Human Equilibrative Nucleoside Transporter 2 Is a Functionally Important Component of Both the Dipyridamole and Nucleoside Binding Sites (2005) (38)
- Predicting gemcitabine transport and toxicity in human pancreatic cancer cell lines with the positron emission tomography tracer 3'-deoxy-3'-fluorothymidine. (2010) (37)
- Specimen quality evaluation in Canadian biobanks participating in the COEUR repository. (2013) (36)
- Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H+ cotransporter (NupC) produced in Xenopus laevis oocytes (2004) (36)
- Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative. (2001) (35)
- Human Nucleoside Transporters: Biomarkers for Response to Nucleoside Drugs (2009) (35)
- Identification and Mutational Analysis of Amino Acid Residues Involved in Dipyridamole Interactions with Human and Caenorhabditis elegans Equilibrative Nucleoside Transporters* (2005) (34)
- Improved syntheses of 5'-S-(2-aminoethyl)-6-N-(4-nitrobenzyl)-5'-thioadenosine (SAENTA), analogues, and fluorescent probe conjugates: analysis of cell-surface human equilibrative nucleoside transporter 1 (hENT1) levels for prediction of the antitumor efficacy of gemcitabine. (2010) (32)
- Measurement and Inhibition of Membrane Transport of Adenosine (1985) (32)
- Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene (2005) (32)
- The Role of Human Nucleoside Transporters in Cellular Uptake of 4′-Thio-β-d-arabinofuranosylcytosine and β-d-Arabinosylcytosine (2006) (31)
- Erlotinib, Gefitinib, and Vandetanib Inhibit Human Nucleoside Transporters and Protect Cancer Cells from Gemcitabine Cytotoxicity (2013) (31)
- Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells. (2005) (30)
- Studies of nucleoside transporters using novel autofluorescent nucleoside probes. (2006) (30)
- Inhibition of uridine uptake in HeLa cells by nitrobenzylthioinosine and related compounds. (1977) (29)
- Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2. (1997) (29)
- Chapter 9 Molecular mechanisms of nucleoside and nucleoside drug transport (2000) (28)
- Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine. (1987) (28)
- Differential cellular retention of vincristine and vinblastine by cultured human promyelocytic leukemia HL-60/Cl cells: the basis of differential toxicity. (1985) (27)
- Nucleobase transporter-mediated permeation of 2',3'-dideoxyguanosine in human erythrocytes and human T-lymphoblastoid CCRF-CEM cells. (1992) (27)
- Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana. (1989) (27)
- An ancient prevertebrate Na+-nucleoside cotransporter (hfCNT) from the Pacific hagfish (Eptatretus stouti). (2002) (27)
- Functional characterization of a H+/nucleoside co‐transporter (CaCNT) from Candida albicans, a fungal member of the concentrative nucleoside transporter (CNT) family of membrane proteins (2003) (27)
- Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells. (1977) (27)
- Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer (2007) (26)
- External location of sites on pig erythrocyte membranes that bind nitrobenzylthioinosine. (1988) (26)
- Functional and Molecular Characterization of Nucleobase Transport by Recombinant Human and Rat Equilibrative Nucleoside Transporters 1 and 2 CHIMERIC CONSTRUCTS REVEAL A ROLE FOR THE ENT2 HELIX 5–6 REGION IN NUCLEOBASE TRANSLOCATION* (2002) (24)
- Human Concentrative Nucleoside Transporter 3 Transfection with Ultrasound and Microbubbles in Nucleoside Transport Deficient HEK293 Cells Greatly Increases Gemcitabine Uptake (2013) (24)
- Inhibition of thymidine uptake in asynchronous HeLa cells by nitrobenzylthioinosine. (1977) (24)
- Breast cancer prediction using genome wide single nucleotide polymorphism data (2013) (24)
- Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3. (2009) (24)
- Immunocytochemical Demonstration of the Equilibrative Nucleoside Transporter rENT1 in Rat Sinoatrial Node (2002) (24)
- Inhibition by nitrobenzylthioinosine of uptake of adenosine, 2'-deoxyadenosine and 9-beta-D-arabinofuranosyladenine by human and mouse erythrocytes. (1975) (23)
- Cysteine-accessibility analysis of transmembrane domains 11-13 of human concentrative nucleoside transporter 3. (2006) (23)
- Effects of inhibition of N-linked glycosylation by tunicamycin on nucleoside transport polypeptides of L1210 leukemia cells. (1990) (23)
- Germline DNA Copy Number Aberrations Identified as Potential Prognostic Factors for Breast Cancer Recurrence (2013) (23)
- CSF‐1 stimulates nucleoside transport in S1 macrophages (1993) (23)
- Density‐dependent resistance to puromycin in cell cultures (1972) (23)
- The role of human nucleoside transporters in cellular uptake of 4'-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine. (2006) (23)
- Density‐dependent inhibition of expression of syncytiotrophoblastic markers by cultured human choriocarcinoma (BeWo) cells (1986) (22)
- Physical properties of human polynucleotide kinase: hydrodynamic and spectroscopic studies. (2001) (22)
- Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in calu-3 cells (2003) (22)
- Mutation of Trp29 of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity. (2008) (22)
- Differential Expression of Human Equilibrative Nucleoside Transporter 1 (hENT1) Protein in the Reed-Sternberg Cells of Hodgkin's Disease (2002) (21)
- Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1. (2011) (21)
- Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors (2001) (21)
- Adenosine transport in cultured cells and erythrocytes. (1987) (21)
- Multidrug resistance of a continuously differentiating monoclonal B lineage in the blood and bone marrow of patients with multiple myeloma. (1992) (21)
- Interactions of Multitargeted Kinase Inhibitors and Nucleoside Drugs: Achilles Heel of Combination Therapy? (2014) (20)
- Identification of glucose and nucleoside transport proteins in neonatal pig erythrocytes using monoclonal antibodies against band 4.5 polypeptides of adult human and pig erythrocytes. (1988) (20)
- Defective transport of thymidine by cultured cells resistant to 5-bromodeoxyuridine. (1977) (20)
- Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line. (1998) (20)
- Multitargeted kinase inhibitors imatinib, sorafenib and sunitinib perturb energy metabolism and cause cytotoxicity to cultured C2C12 skeletal muscle derived myotubes (2018) (19)
- A new fluorescent probe for the equilibrative inhibitor-sensitive nucleoside transporter. 5'-S-(2-aminoethyl)-N6-(4-nitrobenzyl)-5'-thioadenosine (SAENTA)-chi 2-fluorescein. (1991) (19)
- Inhibition of nucleoside uptake in HeLa cells by nitrobenzylthioinosinate. (1978) (19)
- Nucleoside transporter proteins: emerging targets for drug discovery (2000) (19)
- 5'-S-(2-aminoethyl)-N6-(4-nitrobenzyl)-5'-thioadenosine (SAENTA), a novel ligand with high affinity for polypeptides associated with nucleoside transport. Partial purification of the nitrobenzylthioinosine-binding protein of pig erythrocytes by affinity chromatography. (1990) (19)
- Characterization of the Transport Mechanism and Permeant Binding Profile of the Uridine Permease Fui1p of Saccharomyces cerevisiae* (2006) (18)
- Role of Human Nucleoside Transporters in the Cellular Uptake of Two Inhibitors of IMP Dehydrogenase, Tiazofurin and Benzamide Riboside (2005) (18)
- A Proton-mediated Conformational Shift Identifies a Mobile Pore-lining Cysteine Residue (Cys-561) in Human Concentrative Nucleoside Transporter 3* (2008) (18)
- Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry (2005) (18)
- Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex. (2003) (18)
- Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers. (2003) (17)
- A Conformationally Mobile Cysteine Residue (Cys-561) Modulates Na+ and H+ Activation of Human CNT3* (2008) (17)
- Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling. (2007) (17)
- Conserved Glutamate Residues Are Critically Involved in Na+/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter 1 (hCNT1)* (2007) (17)
- Effects of transformation by v-fps on nucleoside transport in Rat-2 fibroblasts. (1992) (16)
- A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer. (2016) (16)
- Immunohistochemistry for human concentrative nucleoside transporter 3 protein predicts fludarabine sensitivity in chronic lymphocytic leukemia (2008) (16)
- Conserved Glutamate Residues Glu-343 and Glu-519 Provide Mechanistic Insights into Cation/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter hCNT3* (2009) (15)
- Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. (1982) (15)
- L1210/B23.1 cells express equilibrative, inhibitor-sensitive nucleoside transport activity and lack two parental nucleoside transport activities. (1992) (15)
- A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility (2012) (15)
- Correspondence Re: J. R. Mackey et al., Immunohistochemical Variation of Human Equilibrative Nucleoside Transporter 1 Protein in Primary Breast Cancers. Clin. Cancer Res., 8: 110ndash;116, 2002. (2003) (15)
- Use of a small reporter molecule to determine cell-surface proteins by capillary electrophoresis and laser-induced fluorescence: use of 5-SAENTA-x8f for quantitation of the human equilibrative nucleoside transporter 1 protein. (2002) (14)
- Resistance to 9-beta-D-arabinofuranosyladenine in cultured leukemia L 1210 cells. (1983) (14)
- Conjugates of Fluorescein and Saenta (5′-S-(2-Aminoethyl)-N 6-(4-nitrobenzyl)-5′-thioadenosine): Flow Cytometry Probes for the ES Nucleoside Transporter Elements of the Plasma Membrane (1994) (14)
- Selective Inhibition of Human Equilibrative and Concentrative Nucleoside Transporters by BCR-ABL Kinase Inhibitors (2016) (14)
- Comparison of the effects on cultured L1210 leukemia cells of the ribosyl, 2'-deoxyribosyl, and xylosyl homologs of tubercidin and adenosine alone or in combination with 2'-deoxycoformycin. (1982) (13)
- Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm (2013) (13)
- Functional production of mammalian concentrative nucleoside transporters in Saccharomyces cerevisiae (2001) (13)
- Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells (2015) (13)
- Adenosine transport: Recent advances in the molecular biology of nucleoside transporter proteins (1998) (13)
- Human concentrative nucleoside transporter 3 is a determinant of fludarabine transportability and cytotoxicity in human renal proximal tubule cell cultures (2008) (12)
- Characterization of Binding of Folates and Antifolates to Brush-Border Membrane Vesicles Isolated from Human Kidney (2005) (12)
- Breast cancer associated germline structural variants harboring small noncoding RNAs impact post-transcriptional gene regulation (2018) (12)
- Influence of Sugar Ring Conformation on the Transportability of Nucleosides by Human Nucleoside Transporters (2011) (12)
- Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes (2010) (12)
- Combination Therapy of Mouse Leukemia L1210 by 1-β-d-Arabinofuranosylcytosine and 6-[(4-Nitrobenzyl)thio]-9-β-d-ribofuranosylpurine (1975) (12)
- Substituted Cysteine Accessibility Method Analysis of Human Concentrative Nucleoside Transporter hCNT3 Reveals a Novel Discontinuous Region of Functional Importance within the CNT Family Motif (G/A)XKX3NEFVA(Y/M/F)* (2009) (12)
- Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans (2004) (12)
- Antiproliferative effects of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and related compounds in combination with adenosine deaminase inhibitors against mouse leukemia L1210/C2 cells in culture. (1979) (12)
- Proteome profile of human breast cancer tissue generated by LC-ESI-MS/MS combined with sequential protein precipitation and solubilization. (2008) (11)
- Equilibrative Nucleoside Transport Proteins (2003) (11)
- Clinically validated benchmarking of normalisation techniques for two-colour oligonucleotide spotted microarray slides. (2003) (11)
- Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance (2017) (11)
- High expression of nucleoside transporter protein hENT1 in Reed–Sternberg cells is associated with treatment failure in relapsed/refractory Hodgkin lymphoma patients treated with gemcitabine, vinorelbine and liposomal doxorubicin – A CALGB 59804 correlative study (2008) (11)
- Characterization of monoclonal antibodies that recognize band 4.5 polypeptides associated with nucleoside transport in pig erythrocytes. (1987) (10)
- Effect of lithium on the myelosuppressive and chemotherapeutic activities of vinblastine. (1981) (10)
- Synthesis and preclinical characterization of 1-(6'-deoxy-6'-[18F]fluoro-β-d-allofuranosyl)-2-nitroimidazole (β-6'-[18F]FAZAL) as a positron emission tomography radiotracer to assess tumor hypoxia. (2016) (10)
- Functional complementation of a membrane transport deficiency in Saccharomyces cerevisiae by recombinant ND4 fusion protein. (1997) (10)
- Cellular Influx, Efflux, and Anabolism of 3-Carboranyl Thymidine Analogs: Potential Boron Delivery Agents for Neutron Capture Therapy (2013) (10)
- Transport of uridine and 3-deazauridine in cultured human lymphoblastoid cells. (1984) (9)
- A study of reproducibility of guanidination-dimethylation labeling and liquid chromatography matrix-assisted laser desorption ionization mass spectrometry for relative proteome quantification. (2007) (9)
- Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1 (2013) (9)
- Renal conservation of folates role of folate transport proteins. (2008) (8)
- HUMAN ENT1 IS PREDICTIVE OF RESPONSE IN PATIENTS WITH PANCREATIC CANCER TREATED WITH GEMCITABINE: RESULTS FROM THE RTOG 9704 PROSPECTIVE RANDOMIZED TRIAL (2007) (8)
- Cytotoxic activity of gemcitabine in cultured cell lines derived from histologically different types of bladder cancer: role of thymidine kinase 2. (2010) (8)
- The effects of hypoxanthine on methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells. (1986) (8)
- Nucleoside transporter gene expression in wild-type and mENT1 knockout mice. (2011) (7)
- The effect of pH on interaction of nitrobenzylthioinosine and hydroxynitrobenzylthioinosine with the nucleoside transporter of human erythrocyte membranes. (1985) (7)
- Identification of Cys 140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine ( NBMPR )-insensitive nucleoside transporter rENT 2 (7)
- Cytotoxic activities of nucleoside and nucleobase analog drugs in malignant mesothelioma: characterization of a novel nucleobase transport activity. (2008) (7)
- Synthesis of substituted-benzyl and sugar-modified analogues of 6-N-(4-nitrobenzyl) adenosine and their interactions with ES nucleoside transport systems (1994) (7)
- Behavioral effects of elevated expression of human equilibrative nucleoside transporter 1 in mice (2011) (7)
- IMPROVED ANTITUMOR EFFECTS IN 3′-BRANCHED HOMOLOGS OF 2′-DEOXYTHIOGUANINE. SYNTHESIS AND EVALUATION OF THIOGUANINE NUCLEOSIDES OF 2,3-DIDEOXY-3-(HYDROXYMETHYL)-D-ERYTHRO-PENTOFURANOSE (1979) (7)
- Hydrodynamic and Spectroscopic Studies of Substrate Binding to Human Recombinant Deoxycytidine Kinase (2003) (7)
- Density-dependent fluctuations in membrane permeability in logarithmically growing cell cultures. (1972) (6)
- Functional expression of the nitrobenzylthioinosine-sensitive nucleoside transporter of human choriocarcinoma (BeWo) cells in isolated oocytes of Xenopus laevis. (1994) (6)
- Glucose and nucleoside transporters of human erythrocytes: effects of detergents on immunoadsorption of a membrane protein to its monoclonal antibody. (1991) (6)
- Chapter 6 Renal Conservation of Folates (2008) (6)
- HPLC reveals novel features of nucleoside and nucleobase homeostasis, nucleoside metabolism and nucleoside transport. (2020) (6)
- Expression of nucleoside transporters and deoxycytidine kinase proteins in muscle invasive urothelial carcinoma of the bladder: correlation with pathological response to neoadjuvant platinum/gemcitabine combination chemotherapy. (2014) (5)
- Prediction of gemcitabine benefit after curative-intent resection of pancreatic adenocarcinoma using HENT1 and dCK protein expression. (2011) (5)
- Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers. (2013) (5)
- Fluorescence energy transfer studies of human deoxycytidine kinase: role of cysteine 185 in the conformational changes that occur upon substrate binding. (2006) (5)
- The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response (2019) (5)
- Transport function and subcellular distribution of purified human erythrocyte glucose transporter reconstituted into rat adipocytes. (1992) (4)
- Antibodies as Probes of Nitrobenzylthioinosine-Sensitive Nucleoside Transporters (1995) (4)
- Allelic isoforms of the H+/nucleoside co‐transporter (CaCNT) from Candida albicans reveal separate high‐ and low‐affinity transport systems for nucleosides (2004) (4)
- Evidence that the transport-related proteins BAT and 4F2hc are not specific for amino acids: induction of Na+-dependent uridine and pyruvate transport activity by recombinant BAT and 4F2hc expressed in Xenopus oocytes. (1998) (4)
- Inhibition of nucleoside transporters by tyrosine kinase inhibitors and its effects on chemotherapy efficacy (2014) (4)
- Role of cysteine 416 in N-ethylmaleimide sensitivity of human equilibrative nucleoside transporter 1 (hENT1). (2018) (4)
- Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells. (2011) (4)
- Spodoptera frugiperda (Sf9) cells express novel purine- and pyrimidine-selective nucleoside transporters (1994) (4)
- Synthesis, transportability and hypoxiaselective binding of 1-beta-D-(5-Deoxy-5-fluororibofuranosyl)-2-nitroimidazole (beta-5-FAZR), a configurational isomer of the clinical hypoxia marker, FAZA. (2007) (4)
- Protecting academic freedom (2008) (3)
- Inhibition of sodium-independent and sodium-dependent nucleobase transport activities by tyrosine kinase inhibitors (2015) (3)
- 9-β-D-Arabinofuranosyladenine (AraA) (1979) (3)
- AntiproliferativeEffects of 9@/J@D@ArabinofuranosyIadenine 5'- Monophosphateand Related Compoundsin Combinationwith AdenosineDeaminaseInhibitorsagainst Mouse Leukemia LI 21O/C2 Cells in Culture1 (1979) (3)
- Fine‐mapping of a novel premenopausal breast cancer susceptibility locus at Chr4q31.22 in Caucasian women and validation in African and Chinese women (2019) (3)
- 552 CYP3A5*3 (rs776746) is associated with docetaxel-specific toxicities during adjuvant breast cancer chemotherapy (2010) (3)
- Abstract P3-08-04: Germline Copy Number Polymorphisms Associated with Toxicity from Adjuvant Docetaxel (2010) (3)
- Combination therapy of mouse leukemia L1210 by 1-beta-D-arabinofuranosylcytosine and 6-[(4-nitrobenzyl)thio]-9-beta-D-ribofuranosylpurine. (1975) (3)
- Distribution and Functional Characterisation of ENT4, a Novel Cardiac Adenosine Transporter Activated at Acidic pH (2006) (2)
- Fluorescence Studies of Substrate Binding to Human Recombinant Deoxycytidine Kinase (2004) (2)
- Characterization of nucleoside and nucleobase transporters in a human mesothelial cell line: evaluation of nucleoside and nucleobase antimetabolites for application in malignant mesothelioma (2006) (2)
- Membrane Transport of Anticancer Drugs and Drug Resistance (1995) (2)
- Differential activity of vinca alkaloids against cultured cells. Abstr. (1983) (2)
- Abstract 797: Interaction of multitargeted tyrosine kinase inhibitors with human nucleoside transporters (2014) (2)
- Transport of A 1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters : Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT 1 (2013) (2)
- The Role of Human Nucleoside Transporters In Uptake of 5-Azacitidine, 5-Aza-2′-Deoxycytidine and Gemcitabine (2010) (2)
- 2-Nitroimidazole-Furanoside Derivatives for Hypoxia Imaging—Investigation of Nucleoside Transporter Interaction, 18F-Labeling and Preclinical PET Imaging (2019) (2)
- Evidence for copurification of micronuclei in sucrose density gradient-enriched plasma membranes from cell lines. (2010) (2)
- Autofluorescent fused-pyrimidine nucleosides: Synthesis and evaluation as permeants and inhibitors of human nucleoside transporters (2011) (2)
- A prospective pharmacogenetic study of 5FU/LV in high-risk stage II and III colon cancer patients. (2004) (2)
- ENT1, Equilibrative Nucleoside Transporter 1 (2008) (1)
- Breast cancer prediction using genome wide single nucleotide polymorphism data (2013) (1)
- Germline copy number variations are associated with breast cancer risk and prognosis (2017) (1)
- Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2). (2012) (1)
- Predicting node positivity in gastric cancer from gene expression profiles (2009) (1)
- Caenorhabditis elegans as a model organism in the study of nucleoside transporters (2002) (1)
- Comparison of coulter volumes with radiometrically determined intracellular water volumes for cultured cells (1989) (1)
- Sodium Dependent, Concentrative Nucleoside Transporters (2008) (0)
- Localization of human equilibrative nucleoside transporter-1 (HENT1) protein in nomral human gastrointestinal tissues (2003) (0)
- Title : Quantitative Analysis of Nucleoside Transporter and Metabolism Gene Expression in Chronic Lymphocytic Leukemia ( CLL ) – Identification of fludarabine-sensitive and insensitive populations Short title : Nucleoside transporter and metabolism expression in CLL (2004) (0)
- Abstract 5452: Inhibition of sodium-independent and sodium-dependent nucleobase transport activities by tyrosine kinase inhibitors (2015) (0)
- Characterization of a human T cell line with acquired drug resistance to 6-mercaptopurine (2006) (0)
- POLARISED DISTRIBUTION OF NUCLEOSIDE TRANSPORTERS IN PRIMARY CULTURED RAT CHOROID PLEXUS EPITHELIAL CELLS (2004) (0)
- Activities of vinblastine. (1981) (0)
- University of Alberta “OMICs” Conference, June 17, 2013: Conference Program and Abstracts (2013) (0)
- Cancer Therapy : Preclinical Erlotinib , Ge fi tinib , and Vandetanib Inhibit HumanNucleoside Transporters and Protect Cancer Cells from Gemcitabine Cytotoxicity (2013) (0)
- CNT2, Concentrative Nucleoside Transporter 2 (2008) (0)
- Resistance to 9-0-D-Arabinofuranosyladenine in Cultured Leukemia L1210 Ceils1 (2006) (0)
- Sensitivity of mammalian equilibrative nucleoside transporters to NBMPR: Identification of an amino acid residue fundamental in sensitivity (2000) (0)
- 128 A comprehensive genomic approach to the identification of predictive markers using dna and tissue repair gene polymorphisms in radiation induced late toxicity in prostate cancer patients treated with conformal radiotherapy (2006) (0)
- Nucleoside transporter profile of human pancreatic cell lines: New therpeutic targets (2001) (0)
- Characterization of a novel nucleoside/nucleobase transporter from Plasmodium falciparum (2000) (0)
- A ) Importance within the CNT Family Motif Novel Discontinuous Region of Functional Nucleoside Transporter hCNT 3 Reveals a Analysis of Human Concentrative Substituted Cysteine Accessibility Method and Biogenesis : Membrane Transport , Structure , Function (2009) (0)
- CNT1, Concentrative Nucleoside Transporter 1 (2008) (0)
- fludarabine-sensitive and -insensitive populations expression in chronic lymphocytic leukemia (CLL): identification of Quantitative analysis of nucleoside transporter and metabolism gene (2013) (0)
- ENT2, Equilibrative Nucleoside Transporter 2 (2008) (0)
- CNT3, Concentrative Nucleoside Transporter 3 (2008) (0)
- Autofluorescent Fused‐Pyrimidine Nucleosides: Synthesis and Evaluation as Permeants and Inhibitors of Human Nucleoside Transporters. (2012) (0)
- The enhancement of 9-beta-d-arabinofuranosylandenine toxicity to mouse leukemia l1210 by an inhibitor of adenosine deaminase. Abstr. (1976) (0)
- Biological and biochemical studies of the effects of xylotubercidin and related compounds on mouse leukemia l1210 in vitro. Abstr. (1977) (0)
- Leukemia L1210 Cells -d-Arabinofuranosyladenine in Cultured β Resistance to 9- (2013) (0)
- Probing the biological roles of nucleoside transporters using Caenorhabditis elegans as a model organism (2000) (0)
- Crystal structure of the FHA domain of mouse polynucleotide kinase in complex with an XRCC4-derived phosphopeptide. (2005) (0)
- Overexpression of the bacterial transporter NupC - a model for mammalian active nucleoside transporters (2000) (0)
- 45th Annual Meeting of the CSBMCB, Banff,Alberta."Membrane Proteins in Health and Disease" (2002) (0)
- P8.04Comparison of Human Nucleoside Transporter Interactions with BCR-ABL Kinase Inhibitors (2015) (0)
- 3.02 – Considerations on Dealing with Tissues and Cell Samples (Include Tissue Banking) (2012) (0)
- Antiproliferative effects of 9-beta-d-arabinofuranosyladenine 5'-monphosphate and related compounds against mouse leukemia l1210/c2 cells in culture. Abstr. (1979) (0)
- Nucleoside transporters in the mammalian heart (2000) (0)
- Analytical Biochemistry (2020) (0)
- 173 Synergistic toxicity of tyrosine kinase inhibitors with Hsp90 inhibitor 17-AAG in lung cancer cell line (2010) (0)
- Facilitated, Equilibrative Nucleoside Transporters (2008) (0)
- L1210/C2 Cells in Culture Adenosine Deaminase Inhibitors against Mouse Leukemia -Monophosphate and Related Compounds in Combination with ' -d-Arabinofuranosyladenine 5 β Antiproliferative Effects of 9- (2013) (0)
- Differential cytologic distribution of nucleoside transporters in pancreatic adenocarcinoma cells and its relation to gemcitabine sensitivity (2001) (0)
- Abstract 3076: Post-transcriptional regulatory mechanisms contributing to the evolution of paclitaxel resistance in breast cancer model cell line, SKBR3 (2015) (0)
- Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme (2005) (0)
- Modulation of tubercidin uptake in human hematopoietic cells by inhibitors of nucleoside transport (1988) (0)
- Breast cancer associated germline structural variants harboring small noncoding RNAs impact post-transcriptional gene regulation (2018) (0)
- Separation of nitrobenzylthioinosine from high affinity binding sites on human erythrocytes by gel chromatography. (1984) (0)
- Effects of gefitinib and vandetanib on human equilibrative nucleoside transporter 1 and on gemcitabine cytotoxicity. (2013) (0)
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