Carol Fierke
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American biochemistry researcher and academic administrator
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Carol Fierkebiology Degrees
Biology
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Biochemistry
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Biology
Carol Fierke's Degrees
- Bachelors Chemistry University of California, Berkeley
- PhD Chemistry Stanford University
Why Is Carol Fierke Influential?
(Suggest an Edit or Addition)According to Wikipedia, Carol A. Fierke is an American biochemist who is the Provost and Executive Vice President for Academic Affairs at Brandeis University. Her research considers biological catalysts and understanding biofunction. She is a Fellow of the American Association for the Advancement of Science and the American Academy of Arts and Letters.
Carol Fierke's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Function and mechanism of zinc metalloenzymes. (2000) (822)
- Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. (1987) (415)
- Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design (1996) (339)
- Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli (1999) (228)
- Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor. (2006) (226)
- Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion (2006) (216)
- Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. (2008) (185)
- Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. (1996) (184)
- Biochemical characterization of the Yersinia YopT protease: Cleavage site and recognition elements in Rho GTPases (2003) (176)
- Zinc hydrolases: the mechanisms of zinc-dependent deacetylases. (2005) (163)
- Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA. (1998) (160)
- Protein component of Bacillus subtilis RNase P specifically enhances the affinity for precursor-tRNAAsp. (1998) (158)
- Ribonuclease P protein structure: evolutionary origins in the translational apparatus. (1998) (152)
- Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion. (2006) (139)
- Evidence for a Catalytic Role of Zinc in Protein Farnesyltransferase (1997) (137)
- Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. (2002) (136)
- Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis (2003) (134)
- Catalysis and inhibition of human carbonic anhydrase IV. (1997) (129)
- Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121. (1992) (127)
- The protein component of Bacillus subtilis ribonuclease P increases catalytic efficiency by enhancing interactions with the 5' leader sequence of pre-tRNAAsp. (1998) (127)
- Hydrogen bond network in the metal binding site of carbonic anhydrase enhances zinc affinity and catalytic efficiency (1995) (127)
- Colorimetric and fluorimetric assays to quantitate micromolar concentrations of transition metals. (2000) (122)
- Insights into enzyme function from studies on mutants of dihydrofolate reductase. (1988) (119)
- Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5′ processing (2012) (115)
- A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P. (1994) (115)
- UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme. (1999) (114)
- Contribution of Fluorine to Protein−Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II (2000) (112)
- Functional consequences of engineering the hydrophobic pocket of carbonic anhydrase II. (1991) (109)
- Fluorescent zinc indicators for neurobiology (2002) (106)
- Magnesium ions are required by Bacillus subtilis ribonuclease P RNA for both binding and cleaving precursor tRNAAsp. (1996) (100)
- Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core residues. (1999) (98)
- High-level 2H/13C/15N labeling of proteins for NMR studies (1995) (97)
- Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites. (1994) (96)
- Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives (2015) (94)
- Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. (2002) (91)
- ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc. (2012) (90)
- The affinity of magnesium binding sites in the Bacillus subtilis RNase P x pre-tRNA complex is enhanced by the protein subunit. (2002) (87)
- H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. (1998) (86)
- Real-time determination of picomolar free Cu(II) in seawater using a fluorescence-based fiber optic biosensor. (2003) (85)
- Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. (1996) (84)
- Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. (1997) (84)
- Fluorescence-based biosensing of zinc using carbonic anhydrase (2001) (80)
- Fluorescence microscopy of stimulated Zn(II) release from organotypic cultures of mammalian hippocampus using a carbonic anhydrase-based biosensor system (2000) (79)
- Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations* (2009) (78)
- Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . (2010) (78)
- An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8 (2014) (76)
- Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. (2001) (76)
- Kinetic and spectroscopic characterization of the gamma-carbonic anhydrase from the methanoarchaeon Methanosarcina thermophila. (1999) (76)
- Transient kinetic approaches to enzyme mechanisms. (1995) (75)
- Determination of picomolar concentrations of metal ions using fluorescence anisotropy: biosensing with a "reagentless" enzyme transducer. (1998) (74)
- HDAC8 substrates: Histones and beyond. (2013) (73)
- In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy. (2014) (72)
- Ribonuclease P: a ribonucleoprotein enzyme. (2000) (71)
- Cu+- and Cu2+-sensitive PEBBLE fluorescent nanosensors using DsRed as the recognition element (2006) (69)
- Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II. (1993) (69)
- Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase. (2001) (68)
- DsRed as a highly sensitive, selective, and reversible fluorescence-based biosensor for both Cu(+) and Cu(2+) ions. (2006) (68)
- Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state. (2000) (66)
- Roles of protein subunits in RNA-protein complexes: lessons from ribonuclease P. (2004) (66)
- Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme. (1998) (65)
- A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors ** (2020) (64)
- The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions (2016) (64)
- Probing determinants of the metal ion selectivity in carbonic anhydrase using mutagenesis. (2004) (64)
- Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. (2001) (63)
- Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase. (1999) (63)
- Kinetic and spectroscopic studies of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. (1993) (63)
- Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity (2011) (62)
- Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. (2010) (61)
- Selection of Carbonic Anhydrase Variants Displayed on Phage (1997) (61)
- The BaeSR regulon is involved in defense against zinc toxicity in E. coli. (2013) (61)
- The 5' leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation. (2005) (60)
- Ligand concentration regulates the pathways of coupled protein folding and binding. (2014) (60)
- Conformational mobility of His-64 in the Thr-200----Ser mutant of human carbonic anhydrase II. (1991) (58)
- Structural characterization of the zinc site in protein farnesyltransferase. (2003) (57)
- The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits. (2001) (57)
- Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion (2012) (56)
- Determinants of catalytic activity and stability of carbonic anhydrase II as revealed by random mutagenesis. (1993) (56)
- Genetically encoded ratiometric biosensors to measure intracellular exchangeable zinc in Escherichia coli. (2011) (55)
- General Base-General Acid Catalysis in Human Histone Deacetylase 8. (2016) (55)
- Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate. (2009) (54)
- Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase. (2002) (52)
- Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. (1993) (52)
- UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism* (2005) (52)
- A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei. (1989) (51)
- Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. (2016) (51)
- Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P. (2002) (51)
- Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs. (2018) (51)
- Expanded dynamic range of free zinc ion determination by fluorescence anisotropy. (1998) (50)
- Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. (1995) (48)
- Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. (2003) (48)
- Uniform 13C isotope labeling of proteins with sodium acetate for NMR studies: application to human carbonic anhydrase II. (1991) (48)
- Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. (2010) (47)
- Role of metals in the reaction catalyzed by protein farnesyltransferase. (2000) (47)
- Mechanism of the Class I KDPG aldolase. (2005) (46)
- Understanding protein palmitoylation: Biological significance and enzymology (2011) (46)
- Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase. (2006) (46)
- Fiber optic biosensor for Co(II) and Cu(II) based on fluorescence energy transfer with an enzyme transducer (1996) (46)
- Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant. (1993) (44)
- Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site. (2001) (44)
- Expression, purification and characterization of the recombinant ribonuclease P protein component from Bacillus subtilis (1998) (44)
- Structural basis of inhibitor affinity to variants of human carbonic anhydrase II. (1995) (44)
- Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions. (2012) (44)
- Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II. (1993) (44)
- Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase. (2006) (44)
- Combinatorial modulation of protein prenylation. (2007) (43)
- Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P. (2010) (43)
- Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis. (2007) (42)
- Structure-Based Identification of HDAC8 Non-histone Substrates. (2016) (42)
- Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma. (1992) (42)
- Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity. (2005) (42)
- Context-dependent substrate recognition by protein farnesyltransferase. (2009) (41)
- On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. (2011) (41)
- Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage. (2007) (40)
- Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. (1997) (40)
- Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. (2000) (40)
- Effects of 5' leader and 3' trailer structures on pre-tRNA processing by nuclear RNase P. (2000) (40)
- Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer (1996) (40)
- Active Site Metal Ion in UDP-3-O-((R)-3-Hydroxymyristoyl)-N-acetylglucosamine Deacetylase (LpxC) Switches between Fe(II) and Zn(II) Depending on Cellular Conditions* (2010) (39)
- Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. (2006) (39)
- Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase. (1986) (39)
- Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation. (2018) (38)
- Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer (2019) (38)
- Role of binding energy with coenzyme A in catalysis by 3-oxoacid coenzyme A transferase. (1995) (37)
- Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP. (2015) (37)
- Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase. (2002) (37)
- Mutagenesis Studies of Protein Farnesyltransferase Implicate Aspartate β352 as a Magnesium Ligand* (2003) (36)
- Inhibitor sensitivity of pulmonary vascular carbonic anhydrase. (1993) (35)
- Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity. (2010) (35)
- Selectivity and sensitivity of fluorescence lifetime-based metal ion biosensing using a carbonic anhydrase transducer. (1999) (35)
- REDESIGNING THE ZINC-BINDING SITE OF HUMAN CARBONIC ANHYDRASE-II - STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON. (1993) (35)
- Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. (2009) (34)
- Determination of zinc using carbonic anhydrase-based fluorescence biosensors. (2008) (34)
- A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P (2014) (34)
- Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release (2015) (34)
- Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants. (2001) (33)
- A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc05771k (2019) (33)
- EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). (2003) (32)
- Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding. (1989) (32)
- Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P* (2015) (32)
- Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase. (2006) (31)
- A bacterial selection for the directed evolution of pyruvate aldolases. (2004) (31)
- Fluorescence lifetime imaging of physiological free Cu(II) levels in live cells with a Cu(II)-selective carbonic anhydrase-based biosensor. (2014) (30)
- The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli. (1991) (30)
- Dissecting allosteric effects of activator–coactivator complexes using a covalent small molecule ligand (2014) (30)
- Mutagenesis of the phosphate‐binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates (2007) (30)
- Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes. (2016) (29)
- Implications for enzymic catalysis from free-energy reaction coordinate profiles. (1987) (28)
- Metal-dependent Deacetylases: Cancer and Epigenetic Regulators. (2016) (28)
- Lysine β311 of Protein Geranylgeranyltransferase Type I Partially Replaces Magnesium* (2004) (27)
- Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 . (2011) (27)
- A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P. (2010) (27)
- Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I. (2005) (27)
- Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis. (2006) (26)
- Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase. (2005) (26)
- An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity. (2014) (25)
- Ionic interactions between PRNA and P protein in Bacillus subtilis RNase P characterized using a magnetocapture-based assay. (2004) (25)
- RNase P enzymes (2013) (24)
- The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases* (2016) (24)
- Differential substrate recognition by isozymes of plant protein-only Ribonuclease P (2016) (24)
- A continuous fluorescent assay for protein prenyltransferases measuring diphosphate release. (2005) (24)
- High-level expression of rat farnesyl:protein transferase in Escherichia coli as a translationally coupled heterodimer. (1998) (24)
- Two functional domains of coenzyme A activate catalysis by coenzyme A transferase. Pantetheine and adenosine 3'-phosphate 5'-diphosphate. (1986) (24)
- Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates. (2010) (24)
- Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group. (2004) (24)
- NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P (2010) (23)
- Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface. (2013) (23)
- Transient-state Kinetic Analysis of Transcriptional Activator·DNA Complexes Interacting with a Key Coactivator* (2011) (22)
- Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries. (2007) (21)
- Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP. (2006) (21)
- Characterization and crystal structure of Escherichia coli KDPGal aldolase. (2008) (21)
- Residue ionization in LpxC directly observed by 67Zn NMR spectroscopy. (2008) (20)
- Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate. (2011) (20)
- Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates. (2012) (19)
- Zinc and Health : Current Status and Future Directions Function and Mechanism of Zinc Metalloenzymes 1 (2000) (19)
- Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers. (2019) (18)
- HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides (2017) (18)
- HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking. (2017) (18)
- Expansion of Protein Farnesyltransferase Specificity Using “Tunable” Active Site Interactions (2012) (18)
- Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators (2018) (17)
- Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA. (2020) (17)
- Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing. (2005) (17)
- Mechanisms of metal-dependent hydrolases in metabolism (2010) (17)
- Binding and cleavage of unstructured RNA by nuclear RNase P. (2011) (16)
- Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS. (2012) (16)
- Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. (2012) (16)
- Interplay between substrate recognition, 5′ end tRNA processing and methylation activity of human mitochondrial RNase P (2018) (16)
- Performance enhancement of fluorescence energy transfer-based biosensors by site-directed mutagenesis of the transducer. (1996) (16)
- Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. (2001) (16)
- Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P (2017) (14)
- Fibroblasts from long-lived rodent species exclude cadmium. (2015) (14)
- The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer. (2011) (14)
- On interpreting the inhibition of and catalysis by dihydrofolate reductase (1987) (13)
- Unexpected specificity within dynamic transcriptional protein–protein complexes (2020) (13)
- Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding. (2015) (12)
- Protein engineering of dihydrofolate reductase. pH dependency of Phe-31 mutants (1987) (12)
- Localization of a protein inhibitor of carbonic anhydrase in pig tissues. (2002) (12)
- Getting a handle on protein prenylation. (2009) (12)
- Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. (2000) (11)
- Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. (2016) (11)
- Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer. (1996) (10)
- Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions. (2006) (9)
- Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism. (2017) (9)
- Unexpected Specificity within Dynamic Transcriptional Protein-Protein Complexes (2020) (9)
- The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases (2019) (9)
- Stereospecific reduction of 2,3-epoxybutanoic acid. Synthesis of (R,R)- and (S,S)-3-hydroxybutanoic-2-d acid and S-tert-butyl 3-acetoxythiobutanoate-2-d (1981) (8)
- Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase. (2002) (8)
- Structure of His94-->Asp carbonic anhydrase II in a new crystalline form reveals a partially occupied zinc binding site. (1995) (8)
- Kinetic mechanism of human mitochondrial RNase P (2019) (8)
- In situ measurement of free zinc in an ischemia model and cell culture using a ratiometric fluorescence-based biosensor (2005) (8)
- Long Wavelength Fluorescence Ratiometric Zinc Biosensor (2013) (8)
- The evolution of RNase P (2015) (8)
- SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent. (2018) (7)
- Global Identification of Protein Prenyltransferase Substrates: Defining the Prenylated Proteome (2011) (7)
- Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant. (2019) (7)
- Active-site engineering of carbonic anhydrase and its application to biosensors. (2000) (7)
- Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis. (2008) (7)
- Energy-transfer-based fiber optic metal ion biosensor (1995) (6)
- Mixed inhibition of adenosine deaminase activity by 1,3-dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically-induced energy deprivation syndromes in brain. (2012) (6)
- Cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and antagonist for amylin fibrillation (2018) (6)
- A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors (2020) (5)
- Importance of Measuring Free Zinc in Cells (2006) (5)
- Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs. (2016) (5)
- Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates (2021) (5)
- Determination of multiple analytes using a fiber optic biosensor based on fluorescence energy transfer (1996) (5)
- Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase P (2020) (4)
- Real-time in-situ determination of free Cu(II) at picomolar levels in sea water using a fluorescence lifetime-based fiber optic biosensor (2002) (4)
- Practical Aspects of Fluorescence Analysis of Free Zinc Ion in Biological Systems: pZn for the Biologist (2005) (4)
- Measuring and Imaging Metal Ions With Fluorescence-Based Biosensors: Speciation, Selectivity, Kinetics, and Other Issues. (2017) (4)
- The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. (2016) (4)
- Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P (2020) (4)
- Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II. (2000) (3)
- Issues in enzyme-based metal ion biosensing in complex media (2000) (3)
- In vivo and intracellular sensing and imaging of free zinc ion (2004) (3)
- Fluorescence-based sensing of transition metal ions by a carbonic anhydrase transducer with a tethered fluorophore (1999) (3)
- Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues. (2016) (3)
- Site-specific mutants of carbonic anhydrase for fluorescence energy-transfer-based metal-ion biosensing (1995) (3)
- Kinetic mechanism of bacterial RNase P (2010) (3)
- Erratum to “Concentrations of extracellular free zinc (pZn)e in the central nervous system of man, rat and rabbit during anesthesia, ischemia and reperfusion” [Exp. Neurol. 198 (2006) 285–293] (2006) (3)
- Insights into Enzymic Catalysis from Studies on Dihydrofolate Reductases (1989) (3)
- High-sensitivity determination of Zn(II) and Cu(II) in vitro by fluorescence polarization (1998) (3)
- Noncanonical Secondary Structure Stabilizes Mitochondrial tRNA by Reducing the Entropic Cost of Tertiary Folding (2015) (3)
- Mobile trap algorithm for zinc detection using protein sensors. (2007) (2)
- Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1. (2017) (2)
- Fluorescence-lifetime-based determination of anions using a site-directed mutant enzyme transducer (1997) (2)
- The wide reach of enzymology: from bioorganic chemistry to chemical biology and beyond Mechanisms (2006) (2)
- Trace Metals in Host-Microbe Interactions: The Microbe Perspective (2015) (2)
- Fluorescence-Based Real-Time Activity Assays to Identify RNase P Inhibitors. (2017) (2)
- Determination of metal ions by fluorescence anisotropy exhibits a broad dynamic range (1998) (1)
- Trace Metals and Infectious Diseases: Trace Metals in Host-Microbe Interactions (2015) (1)
- Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein. (1995) (1)
- Measurement of kinetic isotope effects to probe the reaction mechanism catalyzed by mammalian protein farnesyltransferase (2007) (1)
- A method to assay inhibitors of lipopolysaccharide synthesis. (2008) (1)
- A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease (2022) (1)
- Measuring the Stoichiometry of Magnesium Ions Bound to RNA (2008) (1)
- Ratiometric Zinc Biosensor Based on Bioluminescence Resonance Energy Transfer: Trace Metal Ion Determination with Tunable Response (2022) (1)
- The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I (2001) (1)
- Combining Active Carbonic Anhydrase with Nanogels: Enzyme Protection and Zinc Sensing (2021) (1)
- Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs (2018) (1)
- Effects of Cd on the subcellular localization of transition metals in Saccharomyces cerevisiae (2007) (1)
- Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs. (2016) (1)
- CARBONIC ANHYDRASE II (F131V) (2000) (0)
- Crystal Structure Analysis of Human HDAC8 D101A Variant. (2008) (0)
- Investigating the functional basis for specificity in protein farnesyltransferase (2007) (0)
- Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana after 45-minute soak with juglone (2019) (0)
- Real-time quantitation of Cu(II) by a fluorescence-based biosensing approach (2001) (0)
- Insertion of a bulky residue adjacent to the proton shuttle group in CAII significantly decreases the efficiency of proton transfer (1996) (0)
- Regulation of histone deacetylase 8 substrate specificity (768.14) (2014) (0)
- Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically Encoded Nε-Butyryl-L-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent (2023) (0)
- Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form (2008) (0)
- Carbonic Anhydrase-Based Biosensing of Metal Ions: Issues and Future Prospects (2005) (0)
- Molecular recognition of FTase and GGTase‐I in vivo (2010) (0)
- Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana complexed with Mn after 3-hour soak with juglone (2019) (0)
- Molecular Approaches to Optical Biosensors (1998) (0)
- Structure-Based Identifica tion of HDAC 8 Non-histone Substrates Graphical Abstract Highlights (2016) (0)
- Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana with Mn (2012) (0)
- Crystal Structure Analysis of Human HDAC8 complexed with APHA in a new monoclinic crystal form (2008) (0)
- Ratiometric Bioluminescence-Based Zinc Biosensor with Nanomolar Sensitivity (2015) (0)
- Crystal structure of Co2+ HDAC8 complexed with M344 (2010) (0)
- Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer (2019) (0)
- Correlation between Bacillus subtilis RNase P Conformational Change and Dynamics of P4 Helix Mimic in RNase P RNA (2015) (0)
- Molecular Recognition of Metal Ions by Bacterial Ribonuclease P (2012) (0)
- Zinc catalyzed alkyl-transfer enzymes (2003) (0)
- Improved response of a fluorescence-based metal ion biosensor using engineered carbonic anhydrase variants (1999) (0)
- Determining histone deacetylase 8 substrates using non‐natural amino acids (2017) (0)
- Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor (2022) (0)
- X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT (2001) (0)
- CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE (2000) (0)
- Crystal structure of Aquifex aeolicus LpxC complexed with imidazole. (2006) (0)
- Toolbox to evaluate biological function of histone deacetylases (2020) (0)
- Catalytic metal ion switching in zinc‐dependent deacetylases (2008) (0)
- Determining histone deacetylase 8 substrates using non‐natural amino acids (2016) (0)
- X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT (2001) (0)
- Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana after 3-hour soak with juglone (2019) (0)
- Optimization of Biosensors by Directed Evolution (2003) (0)
- Apolipoprotein A-I Mimetic 4F Peptide Generates Amyloid Cytotoxins by Forming Hetero-oligomers with β-amyloid (2019) (0)
- Imaging Intracellular and Intra-Mitochondrial Free Zinc Ion Concentrations Following Hypoxia/Hypoglycemia with an Expressible Fluorescence Biosensor (2011) (0)
- Substrate Recognition by Human Mitochondrial RNase P: Moonlighting of a tRNA Methyltransferase (2015) (0)
- Investigating the catalytic mechanism of the yeast palmitoyltransferase Akr1p (2010) (0)
- Crystal structure of Aquifex aeolicus LpxC deacetylase complexed with cacodylate (2005) (0)
- Mode of inhibition of RNase P by gambogic acid and juglone (2022) (0)
- Molecular recognition of pre-tRNA by protein-only Ribonuclease P. (2017) (0)
- Measuring Readily Exchangeable Zinc in Escherichia coli by Carbonic Anhydrase‐based Expressible Ratiometric Zinc Sensor (2010) (0)
- Crystal Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana, SeMet substituted form with Sr (2012) (0)
- Factors Affecting Histone Deacetylase 1 Activity and Selectivity (2020) (0)
- Trace Metals in Host–Microbe Interactions (2015) (0)
- Crystal structure of D101L Co2+ HDAC8 complexed with M344 (2010) (0)
- CB&DD Editorial Advisory Board (tenth in series) (2006) (0)
- UDP‐3‐O‐(R‐3‐hydroxymyristoyl)‐N‐acetylglucosamine deacetylase functions as a Zn(II) or Fe(II)‐dependent enzyme (2007) (0)
- Crystal Structure of nuclear proteinaceous RNase P 2 (PRORP2) from A. thaliana (2015) (0)
- Catalytic activity of HDAC8 and HDAC11 (2010) (0)
- Toolbox to evaluate biological function of histone deacetylases (2021) (0)
- X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT (2001) (0)
- Crystal structure of Aquifex aeolicus LpxC Deacetylase (Zinc-Inhibited Form) (2003) (0)
- The Gowland Hopkins Lecture: The Mechanisms of Action of Folate and Pterin Requiring Enzymes (1986) (0)
- Biosensor Design: Combinatorial and Rational Approaches (1998) (0)
- CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE (2000) (0)
- Gambogic acid and juglone inhibit RNase P through distinct mechanisms (2022) (0)
- The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I 2 (2019) (0)
- CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE (2000) (0)
- Travel Awards for 2007 (2007) (0)
- The Bacillus subtilis RNase P holoenzyme is a tetramer composed of two RNase P RNA and two RNase P protein subunits. (2001) (0)
- A Novel Y-Shaped, S-O-N-O-S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease. (2023) (0)
- Long Wavelength Fluorescence Ratiometric Zinc Biosensor (2013) (0)
- Fluorescent Metal Ion Biosensing: A Tool for Measuring Zn(II) at The Molecular Level (2007) (0)
- X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT (2001) (0)
- Role of protein prenyltransferases in modifying effectors from infectious bacterium (739.7) (2014) (0)
- Flim of Physiological Free CU(II) in Living Cells with a Protein-Based Biosensor (2011) (0)
- Crystal structure of Aquifex aeolicus LpxC complexed with TU-514 (2006) (0)
- Imaging Intracellular and Intramitochondrial Zinc Concentrations Following Hypoxia/Hypoglycemia with an Expressible Fluorescence Biosensor (2011) (0)
- Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana after overnight soak with juglone (2019) (0)
- Determinants of the peptide specificity of protein farnesyltransferase (2003) (0)
- The wide reach of enzymology: from bioorganic chemistry to chemical biology and beyond (2007) (0)
- Protein farnesyltransferase exhibits pH-dependent activity towards H-Ras peptide substrates (2002) (0)
- Crystal Structure Analysis of human HDAC8 H143A variant complexed with substrate. (2008) (0)
- Metal Ion Biosensor for Wastewater Discharge (2003) (0)
- EUKARYOTIC RIBONUCLEASE P: A Plurality of (2002) (0)
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