Carol MacKintosh
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Computer Science
Carol MacKintosh's Degrees
- PhD Computer Science Stanford University
- Masters Artificial Intelligence University of California, Berkeley
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Why Is Carol MacKintosh Influential?
(Suggest an Edit or Addition)According to Wikipedia, Carol MacKintosh FRSB, is a cell and developmental biologist, Professor of Molecular Signalling and Head of Postgraduate Studies, at the School of Life Sciences, University of Dundee. Early career and research Carol MacKintosh received her education at the University of Aberdeen. She went on to do her PhD at the University of Glasgow. The PhD study focused on the branch-point between the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli, and was conducted alongside Professor Hugh Nimmo at the University of Glasgow. From 2003, Carol MacKintosh has worked at the University of Dundee and is working as a Professor of Molecular Signalling and Head of Postgraduate Studies. Her recent research focus is on how insulin regulates the 14-3-3-interacting phosphoproteome, it has provided a significant understanding into the evolution of cell signalling networks, and provided a foundation and a better understanding of how signalling networks are uncontrolled in diseases such as cancer, neurological disorders, and diabetes.
Carol MacKintosh's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants (1990) (1534)
- Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. (1992) (541)
- Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. (2004) (521)
- 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. (2004) (476)
- Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1 (2001) (349)
- Bioinformatic and experimental survey of 14-3-3-binding sites (2010) (300)
- Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins. (1999) (280)
- AMP‐activated protein kinase: a cellular energy sensor that comes in 12 flavours (2016) (263)
- The cyanobacterial toxin microcystin binds covalently to cysteine‐273 on protein phosphatase 1 (1995) (260)
- Inhibitors of protein kinases and phosphatases. (1994) (259)
- PRAS40 Is a Target for Mammalian Target of Rapamycin Complex 1 and Is Required for Signaling Downstream of This Complex* (2007) (251)
- Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin (1996) (249)
- Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. (2008) (213)
- 14‐3‐3s regulate global cleavage of their diverse binding partners in sugar‐starved Arabidopsis cells (2000) (197)
- Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. (2007) (187)
- Tautomycin from the bacterium Streptomyces verticillatus (1990) (171)
- Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. (2009) (166)
- Modulators of 14-3-3 Protein–Protein Interactions (2017) (160)
- Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose. (2006) (159)
- Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking (2011) (154)
- Purification of type 1 protein (serine/threonine) phosphatases by microcystin‐Sepharose affinity chromatography (1994) (142)
- 14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides (2015) (140)
- Identification of a Protein That Inhibits the Phosphorylated Form of Nitrate Reductase from Spinach (Spinacia oleracea) Leaves (1995) (137)
- Metabolic enzymes as targets for 14-3-3 proteins (2002) (132)
- Regulation of spinach-leaf nitrate reductase by reversible phosphorylation. (1992) (132)
- Identification of high levels of type 1 and type 2A protein phosphatases in higher plants. (1989) (130)
- Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues. (1993) (129)
- Three spinach leaf nitrate reductase-3-hydroxy-3-methylglutaryl-CoA reductase kinases that are regulated by reversible phosphorylation and/or Ca2+ ions. (1997) (120)
- Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase. (1991) (115)
- Sucrose‐phosphate synthase is dephosphorylated by protein phosphatase 2A in spinach leaves (1990) (114)
- Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle (2009) (113)
- ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa (2010) (109)
- Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. (2004) (104)
- Protein phosphatase inhibitors activate anti‐fungal defence responses of soybean cotyledons and cell cultures (1994) (104)
- 14‐3‐3s regulate fructose‐2,6‐bisphosphate levels by binding to PKB‐phosphorylated cardiac fructose‐2,6‐bisphosphate kinase/phosphatase (2003) (98)
- Purification of the hepatic glycogen‐associated form of protein phosphatase‐1 by microcystin‐Sepharose affinity chromatography (1995) (87)
- Regulation of plant NR activity by reversible phosphorylation, 14-3-3 proteins and proteolysis (2001) (84)
- Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets* (2009) (82)
- Purification of a nitrate reductase kinase from Spinacea oleracea leaves, and its identification as a calmodulin-domain protein kinase (1998) (81)
- Differential 14-3-3 Affinity Capture Reveals New Downstream Targets of Phosphatidylinositol 3-Kinase Signaling* (2009) (79)
- Identification of a regulatory phosphorylation site in the hinge 1 region of nitrate reductase from spinach (Spinacea oleracea) leaves (1995) (78)
- AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues (2012) (74)
- Visualization and Biochemical Analyses of the Emerging Mammalian 14-3-3-Phosphoproteome* (2011) (68)
- The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin (2011) (64)
- Viral, parasitic and prion diseases of farmed deer and bison. (2002) (64)
- Further evidence that inhibitor‐2 acts like a chaperone to fold PP1 into its native conformation (1996) (60)
- A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin. (1992) (56)
- ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome (2014) (55)
- Illumination increases the phosphorylation state of maize leaf phosphoenolpyruvate carboxylase by causing an increase in the activity of a protein kinase. (1991) (52)
- Regulation of cytosolic enzymes in primary metabolism by reversible protein phosphorylation. (1998) (52)
- Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates (2012) (49)
- Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428. (2005) (49)
- Bacterial diseases of farmed deer and bison. (2002) (47)
- A cDNA encoding rabbit muscle protein phosphatase 1 alpha complements the Aspergillus cell cycle mutation, bimG11. (1991) (45)
- Cytosolic glutamine synthetase and not nitrate reductase from the green alga Chlamydomonas reinhardtii is phosphorylated and binds 14-3-3 proteins (2001) (40)
- Disruption of the AMPK–TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion (2016) (39)
- Phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G in response to adrenalin (1988) (39)
- Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells. (2002) (37)
- Purification and regulatory properties of isocitrate lyase from Escherichia coli ML308. (1988) (37)
- Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes. (2009) (37)
- Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle. (2012) (33)
- GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins. (2014) (33)
- SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain (2019) (33)
- Effect of IRS4 Levels on PI 3-Kinase Signalling (2013) (31)
- Activation of an interleukin‐4 mRNA‐producing population of peripheral blood mononuclear cells after infection with Mycobacterium bovis or vaccination with killed, but not live, BCG (1996) (31)
- Microcystin affinity purification of plant protein phosphatases: PP1C, PP5 and a regulatory A‐subunit of PP2A (1999) (31)
- Molecular cloning and over-expression of the glyoxylate bypass operon from Escherichia coli ML308. (1987) (30)
- A Tbc1d1Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice (2017) (28)
- Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling (2007) (23)
- Regulation of plant nitrate assimilation: from ecophysiology to brain proteins (1998) (22)
- Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays. (2003) (21)
- A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis (2020) (20)
- Protein histidine phosphatase activity in rat liver and spinach leaves (1995) (20)
- 14‐3‐3 Binding to Pim‐phosphorylated Ser166 and Ser186 of human Mdm2 – Potential interplay with the PKB/Akt pathway and p14ARF (2009) (20)
- Identification of a cysteine residue at the active site of Escherichia coli isocitrate lyase. (1989) (20)
- Affinity purification of diverse plant and human 14-3-3-binding partners. (2001) (20)
- ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase (2012) (20)
- The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids (2016) (19)
- Regulation of the enzymes at the branchpoint between the citric acid cycle and the glyoxylate bypass in Escherichia coli. (1987) (18)
- The Inhibition of Protein Phosphatases by Toxins: Implications for Health and an Extremely Sensitive and Rapid Bioassay for Toxin Detection (1994) (18)
- Recent advances in understanding the roles of whole genome duplications in evolution (2017) (15)
- Faculty Opinions recommendation of Evolution of ecological dominance of yeast species in high-sugar environments. (2017) (12)
- Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic Double-stranded RNA Recognition Pathway* (2014) (12)
- Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers (2014) (11)
- Post-Translational Modifications in Plants: Regulation of plant metabolism by reversible protein (serine/threonine) phosphorylation (1993) (11)
- Synthesis and use of the protein phosphatase affinity matrices microcystin-sepharose and microcystin-biotin-sepharose. (2007) (10)
- Identification of the Amino Acids 300–600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573 (2012) (10)
- Development of a colorimetric protein phosphorylation assay for detecting cyanobacterial toxins (1995) (10)
- Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders* (2015) (10)
- Use of a protein phosphatase inhibition test for the detection of cyanobacterial toxins in water (1995) (10)
- Recent advances in understanding the roles of whole genome duplications in evolution. (2017) (9)
- Plant protein phosphatases Subcellular distribution , detection of protein phosphatase 2 C and identification of protein phosphatase 2 (9)
- Disruption of the AMPK-TBC 1 D 1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF 1 secretion (2016) (8)
- CHAPTER 102 – Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases (2003) (7)
- Mechanism of Activation of PKB/Akt by the Protein Phosphatase Inhibitor Calyculin A (2010) (7)
- Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators (2021) (7)
- Affinity methods for phosphorylation-dependent interactions. (2004) (6)
- Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to insulin-like growth factor 1, EGF, PMA and AICAR (2007) (6)
- Characterization of the major phosphofructokinase-dephosphorylating protein phosphatases from Ascaris suum muscle. (1992) (6)
- Phosphodiesterase 3 A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser 428 (2005) (5)
- Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases (2010) (5)
- Do 14-3-3s regulate‘Resource Allocation in Crops’? (2001) (3)
- Signalling pathways that target diverse plant and human 14-3-3-binding partners (2002) (3)
- Molecular cloning and over-expression of the glyoxylate bypass operon from Escherichia coli ML 308 (2005) (3)
- Isolation of 14-3-3 binding proteins from Hydra (2005) (3)
- Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers. (2014) (2)
- Faculty Opinions recommendation of The octopus genome and the evolution of cephalopod neural and morphological novelties. (2017) (2)
- Purification and properties of Escherichia coli isocitrate lyase (1986) (2)
- A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis (2020) (1)
- A novel transcriptional repressor controlled by Erk/p90RSK/14-3-3 signalling impacts on expression of PEA3 Ets transcription factors (2011) (1)
- Faculty Opinions recommendation of Early genome duplications in conifers and other seed plants. (2017) (1)
- University of Dundee AS 160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues (2012) (0)
- Faculty Opinions recommendation of Whole genome duplication in coast redwood (Sequoia sempervirens) and its implications for explaining the rarity of polyploidy in conifers. (2017) (0)
- Viral diseases: DNA viruses (2020) (0)
- Faculty Opinions recommendation of A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. (2018) (0)
- Two is the key to 14-3-3: dimeric mechanical signaling devices (2010) (0)
- Faculty Opinions recommendation of Reconstructing the genome of the most recent common ancestor of flowering plants. (2017) (0)
- Recent advances in understanding the roles of whole genome duplications in evolution [version 1; referees: 2 approved] (2017) (0)
- University of Dundee The E 3 ubiquitin ligase ZNRF 2 is a substrate of mTORC 1 and regulates its activation by amino (2016) (0)
- Identification of a Protein That lnhibits the Phosphorylated Form of Nitrate Reductase from Spinach (Spina (2002) (0)
- Faculty Opinions recommendation of A comprehensive draft genome sequence for lupin (Lupinus angustifolius), an emerging health food: insights into plant-microbe interactions and legume evolution. (2017) (0)
- The enzymes of the glyoxylate bypass operon of Escherichia coli ML308 (1987) (0)
- Faculty Opinions recommendation of The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4. (2019) (0)
- 14-3-3 Phosphoproteomics for linking signalling pathways to cellular processes (2005) (0)
- Faculty Opinions recommendation of Deeply conserved synteny resolves early events in vertebrate evolution. (2021) (0)
- REGULATION OF PHOSPHODIESTERASE 3A IN HUMAN PLATELETS IS MEDIATED BY PROTEIN KINASE C (2007) (0)
- 14-3-3-Target interactions in sugar-sensing and cell survival in Arabidopsis cells. (2000) (0)
- Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology (2010) (0)
- Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. (2022) (0)
- Faculty of 1000 evaluation for Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity. (2018) (0)
- Faculty Opinions recommendation of Involvement of auxin and brassinosteroid in dwarfism of autotetraploid apple (malus × domestica). (2017) (0)
- 14-3-3 proteins: from plant nitrate reductase to wider roles in plant responses to hormones, stresses, and nutrients (1998) (0)
- Faculty Opinions recommendation of OHNOLOGS v2: a comprehensive resource for the genes retained from whole genome duplication in vertebrates. (2019) (0)
- Faculty of 1000 evaluation for Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. (2018) (0)
- Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells (2022) (0)
- Faculty Opinions recommendation of Magic roundabout is an endothelial-specific ohnolog of ROBO1 which neo-functionalized to an essential new role in angiogenesis. (2019) (0)
- Faculty Opinions recommendation of The abundance of homoeologue transcripts is disrupted by hybridization and is partially restored by genome doubling in synthetic hexaploid wheat. (2017) (0)
- Faculty Opinions recommendation of Quantification of spatiotemporal patterns of Ras isoform expression during development. (2017) (0)
- Faculty Opinions recommendation of Genome analysis of Hibiscus syriacus provides insights of polyploidization and indeterminate flowering in woody plants. (2017) (0)
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