Carol Prives

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Carol Prives is affiliated with the following schools: McGill University, Weizmann Institute of Science, Albert Einstein College of Medicine, Columbia University

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Carol Prives

Biology

#4280

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Biochemistry

#593

World Rank

#684

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Biology

Why Is Carol Prives Influential?

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According to Wikipedia, Professor Carol L. Prives FRS is the Da Costa Professor of Biological Sciences at Columbia University. She is known for her work in the characterisation of p53, an important tumor suppressor protein frequently mutated in cancer.

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Carol Prives's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Blinded by the Light: The Growing Complexity of p53 (2009) (2841)
p53: puzzle and paradigm. (1996) (2530)
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 (1997) (2184)
The p53 pathway (1999) (1429)
Enhanced phosphorylation of p53 by ATM in response to DNA damage. (1998) (1396)
A role for ATR in the DNA damage-induced phosphorylation of p53. (1999) (1136)
Identification of p53 as a sequence-specific DNA-binding protein (1991) (1055)
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. (2000) (1051)
Mutant p53: one name, many proteins. (2012) (1024)
Regulation of p53 activity through lysine methylation (2004) (784)
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. (1996) (780)
Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication (1998) (757)
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway (2012) (728)
Signaling to p53 Breaking the MDM2–p53 Circuit (1998) (685)
E1A signaling to p53 involves the p19(ARF) tumor suppressor. (1998) (685)
Wild-type p53 activates transcription in vitro (1992) (600)
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species (2010) (563)
PML is induced by oncogenic ras and promotes premature senescence. (2000) (550)
Transcriptional regulation by p53: one protein, many possibilities (2006) (508)
A Subset of Tumor-Derived Mutant Forms of p53 Down-Regulate p63 and p73 through a Direct Interaction with the p53 Core Domain (2001) (496)
Identification of redox/repair protein Ref-1 as a potent activator of p53. (1997) (494)
Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53 (2000) (425)
p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells (1999) (424)
Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling (2014) (399)
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus (1995) (383)
Transcriptional regulation by p53. (2010) (381)
Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases (1995) (355)
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication (1991) (346)
A role for p53 in base excision repair (2001) (342)
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. (1990) (325)
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. (1992) (323)
DNA damage‐inducible phosphorylation of p53 at N‐terminal sites including a novel site, Ser20, requires tetramerization (1999) (322)
High mobility group protein-1 (HMG-1) is a unique activator of p53. (1998) (319)
P53 and Prognosis New Insights and Further Complexity (2005) (289)
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis (1996) (286)
The p53 protein is an unusually shaped tetramer that binds directly to DNA. (1993) (281)
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. (1993) (278)
The Chk2 protein kinase. (2004) (260)
Ref‐1 regulates the transactivation and pro‐apoptotic functions of p53 in vivo (1999) (251)
Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. (1992) (251)
TAp63 prevents premature aging by promoting adult stem cell maintenance. (2009) (250)
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. (2004) (245)
Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation (1995) (238)
Why Is p53 Acetylated? (2001) (220)
Cyclin G recruits PP2A to dephosphorylate Mdm2. (2002) (219)
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression (2019) (207)
Ribosomal protein S7 is both a regulator and a substrate of MDM2. (2009) (205)
The Mdm2 RING domain C‐terminus is required for supramolecular assembly and ubiquitin ligase activity (2007) (204)
p53 linear diffusion along DNA requires its C terminus. (2004) (200)
Erratum: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication (Molecular and Cellular Biology 18:1 (629)) (1998) (197)
The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen (1989) (194)
The Roles of MDM2 and MDMX in Cancer. (2016) (192)
p53 accumulates but is functionally impaired when DNA synthesis is blocked. (2001) (181)
p53-dependent Induction of PVT1 and miR-1204* (2011) (178)
The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (1998) (178)
Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function? (2007) (178)
p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein (2001) (177)
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner (1997) (175)
hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes (2007) (174)
p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. (1995) (171)
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress (2012) (171)
Cell-cycle related regulation of poly(A) polymerase by phosphorylation (1996) (170)
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 (2011) (166)
Mutant p53 proteins bind DNA abnormally in vitro. (1991) (153)
The replication functions of SV40 T antigen are regulated by phosphorylation (1990) (151)
Pro-proliferative FoxM1 is a target of p53-mediated repression (2009) (151)
Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein (2002) (147)
The C-terminus of p53 binds the N-terminal domain of MDM2 (2010) (147)
At the Crossroads of Inflammation and Tumorigenesis (1999) (146)
Covalent and noncovalent modifiers of the p53 protein (1999) (144)
The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells (2002) (141)
The C-terminus of p53: the more you learn the less you know (2001) (139)
Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network (2013) (138)
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation. (1993) (135)
Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen. (1977) (133)
Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo (1996) (132)
DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation (2005) (130)
The transforming activity of simian virus 40 large tumor antigen. (1994) (128)
Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. (2011) (124)
p53 tumor suppressor protein regulates the levels of huntingtin gene expression (2006) (120)
MOZ increases p53 acetylation and premature senescence through its complex formation with PML (2013) (118)
The p53 tumor suppressor protein: meeting review. (1993) (117)
How loops, β sheets, and α helices help us to understand p53 (1994) (114)
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells (2015) (114)
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling (2020) (111)
p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A (1996) (111)
A role of cyclin G in the process of apoptosis (1999) (109)
Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response* (2003) (108)
Unleashing the power of p53: lessons from mice and men. (2006) (108)
Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non‐consensus sites (1998) (107)
P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation (2006) (107)
Regulation of Mutant p53 Temperature-sensitive DNA Binding* (1996) (100)
p53 tumour suppressor (1998) (100)
Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen. (1990) (97)
A signaling to p 53 involves the p 19 ARF tumor suppressor (1998) (96)
p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation (2008) (96)
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain. (2015) (92)
Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay (1998) (91)
Checkpoint Kinase 2 (Chk2) Monomers or Dimers Phosphorylate Cdc25C after DNA Damage Regardless of Threonine 68 Phosphorylation* (2002) (89)
Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes. (2017) (84)
Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53. (2017) (84)
p53 responsive elements in human retrotransposons (2009) (81)
Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. (2011) (81)
Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block* (2004) (80)
Species-specific in vitro synthesis of DNA containing the polyoma virus origin of replication. (1986) (80)
p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation (2011) (79)
Cyclin A-CDK Phosphorylation Regulates MDM2 Protein Interactions* (2001) (79)
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis (2008) (78)
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein. (1996) (77)
p53 represses Sp1 DNA binding and HIV-LTR directed transcription. (1997) (77)
The S phase checkpoint: when the crowd meets at the fork. (2005) (76)
p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer. (2003) (76)
The p21 and PCNA partnership: A new twist for an old plot (2008) (75)
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. (2003) (73)
p73α Regulation by Chk1 in Response to DNA Damage (2003) (71)
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. (2009) (70)
Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs (1984) (69)
Relevance of the p53–MDM2 axis to aging (2017) (67)
U2 snRNA sequences that bind U2-specific proteins are dispensable for the function of U2 snRNP in splicing. (1989) (67)
Cyclin-dependent Kinases Phosphorylate p73 at Threonine 86 in a Cell Cycle-dependent Manner and Negatively Regulate p73* (2003) (66)
A small subclass of SV40 T antigen binds to the viral origin of replication (1982) (65)
P53 and PML: new partners in tumor suppression. (2001) (65)
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. (2012) (65)
Accurate and sensitive quantification of protein-DNA binding affinity (2018) (65)
Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites (1987) (64)
Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner (2008) (64)
Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression. (1982) (63)
The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein. (2016) (59)
Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA (1982) (59)
Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response*♦ (2009) (59)
p53-Dependent p21 mRNA Elongation Is Impaired when DNA Replication Is Stalled (2006) (59)
Alternative splicing of SV40 early pre-mRNA is determined by branch site selection. (1988) (58)
Excess HDM2 Impacts Cell Cycle and Apoptosis and Has a Selective Effect on p53-dependent Transcription* (2006) (58)
Discrete regions of simian virus 40 large T antigen are required for nonspecific and viral origin-specific DNA binding (1982) (57)
p53 in the Cytoplasm A Question of Overkill? (2004) (55)
APC/CCdc20 targets E2F1 for degradation in prometaphase (2010) (55)
Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA (1997) (55)
Getting p53 Out of the Nucleus (2001) (55)
The N Terminus of p53 Regulates Its Dissociation from DNA* (2000) (55)
Inhibition of viral protein synthesis in monkey cells treated with interferon late in simian virus 40 lytic cycle (1977) (54)
Relevance of the p53-MDM2 axis to aging. (2018) (53)
How loops, beta sheets, and alpha helices help us to understand p53. (1994) (53)
DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication (1983) (53)
Deconstruction of p53 functions and regulation (2002) (52)
p53 and p73 display common and distinct requirements for sequence specific binding to DNA (2006) (52)
Assembly of functional U1 and U2 human-amphibian hybrid snRNPs in Xenopus laevis oocytes. (1988) (52)
DECOD: fast and accurate discriminative DNA motif finding (2011) (50)
Mutational Analysis of the p53 Core Domain L1 Loop* (2006) (50)
DNA sequence requirements for replication of polyomavirus DNA in vivo and in vitro (1987) (49)
Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells (2016) (48)
Gain-of-function mutant p53: history and speculation (2019) (48)
p53: more research and more questions (2006) (48)
Dysfunction of the MDM2/p53 axis is linked to premature aging. (2017) (47)
Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication (1998) (47)
P53 and aging: A fresh look at an old paradigm (2010) (45)
p53 leans on its siblings. (2002) (45)
Stxbp4 Regulates ΔNp63 Stability by Suppression of RACK1-Dependent Degradation (2009) (45)
Cellular and cell-free synthesis of simian virus 40 T-antigens in permissive and transformed cells (1978) (45)
Cancer: DNA damage enables p73 (1999) (44)
p73alpha regulation by Chk1 in response to DNA damage. (2003) (43)
UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability (2013) (43)
Cyclin G Recruits PP 2 A to Dephosphorylate Mdm 2 (2002) (42)
p53: upstream, downstream and off stream. Review of the 8th p53 workshop (Dundee, July 5-9, 1996). (1996) (42)
Mdm2 and MdmX as Regulators of Gene Expression. (2012) (41)
The DNA-binding properties of polyomavirus large T antigen are altered by ATP and other nucleotides (1991) (41)
Binding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigen (1990) (40)
Cell-free translation of messenger RNA of simian virus 40: synthesis of the major capsid protein. (1974) (40)
Stability of Checkpoint Kinase 2 Is Regulated via Phosphorylation at Serine 456* (2007) (39)
p53 inhibits DNA replication in vitro in a DNA-binding-dependent manner (1995) (39)
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry (2013) (38)
Differential affinities of simian virus 40 large tumor antigen for DNA. (1980) (38)
A comparison of the translation of Mengo virus RNA and globin mRNA in krebs ascites cell‐free extracts (1972) (38)
Inhibition of TFII-I-Dependent Cell Cycle Regulation by p53 (2005) (37)
Doing the right thing: feedback control and p53. (1993) (36)
p53: master of life, death, and the epigenome (2017) (36)
Erratum: Cooperative DNA binding of p53 with TFIID (TBP): A possible mechanism for transcriptional activation (Genes and Development 7 (1837- 1849)) (1993) (36)
Association of simian virus 40 T antigen with the nuclear matrix of infected and transformed monkey cells (1984) (35)
p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner (2008) (35)
Simian virus 40 and polyomavirus large tumor antigens have different requirements for high-affinity sequence-specific DNA binding (1985) (35)
Poly(A) Polymerase Phosphorylation Is Dependent on Novel Interactions with Cyclins (2000) (34)
Transcriptional Regulation by p 53 (2010) (34)
In vitro splicing of simian virus 40 early pre mRNA. (1986) (32)
Does control of mutant p53 by Mdm2 complicate cancer therapy? (2008) (32)
Baculovirus p33 Binds Human p53 and Enhances p53-Mediated Apoptosis (1999) (32)
Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus (2007) (31)
DNA binding properties of simian virus 40 T-antigens synthesized in vivo and in vitro (1980) (30)
Functional dissection of p53 tumor suppressor protein. (1997) (30)
The cell-free translation of SV40 messenger RNA. (1975) (30)
Mutant p53 gain of function: the NF-Y connection. (2006) (30)
DNA helicase and duplex DNA fragment unwinding activities of polyoma and simian virus 40 large T antigen display similarities and differences. (1991) (29)
The roles and regulation of MDM2 and MDMX: it is not just about p53 (2021) (29)
ATP induces the assembly of polyoma large tumor antigen into hexamers. (1991) (28)
Characterization of Measles Virus-Specific Proteins Synthesized In Vivo and In Vitro from Acutely and Persistently Infected Cells (1979) (28)
Expression of polyomavirus large T antigen by using a baculovirus vector (1987) (28)
The continuing saga of p53--more sleepless nights ahead. (2005) (27)
Study of the Functional Activities Concomitantly Retained by the 115,000 Mr Super T Antigen, an Evolutionary Variant of Simian Virus 40 Large T Antigen Expressed in Transformed Rat Cells (1983) (27)
Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities (2009) (26)
Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein (2009) (26)
The replication functions of polyomavirus large tumor antigen are regulated by phosphorylation (1993) (26)
MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress (2012) (26)
p 53 Mutants in Mammalian Cells p 73 Function Is Inhibited by Tumor-Derived (1999) (26)
DNA binding and sedimentation properties of SV40 T antigens synthesized in vivo and in vitro. (1980) (25)
Cancer: Mutant p53 and chromatin regulation (2015) (25)
Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences (1988) (25)
STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis (2018) (25)
Helicase, DNA-binding, and immunological properties of replication-defective simian virus 40 mutant T antigens (1989) (24)
Transcriptional regulation by p53 and p73. (2005) (24)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018) (24)
Xenopus laevis p53 protein: sequence-specific DNA binding, transcriptional regulation and oligomerization are evolutionarily conserved. (1995) (23)
The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling (2018) (23)
Targeting mutant p53 through the mevalonate pathway (2016) (22)
Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation. (1993) (22)
p21 can be a barrier to ferroptosis independent of p53 (2020) (22)
Effect of cerebral stimulation on biosynthesis of nucleotides and RNA in brain slices in vitro. (1969) (22)
A unique subpopulation of murine DNA polymerase alpha/primase specifically interacts with polyomavirus T antigen and stimulates DNA replication (1994) (21)
Molecular biology. Getting p53 out of the nucleus. (2001) (21)
Use of oligonucleotides for antisense experiments in Xenopus laevis oocytes. (1991) (21)
Lysine-Independent Turnover of Cyclin G1 Can Be Stabilized by B′α Subunits of Protein Phosphatase 2A (2008) (21)
Regulation of p53 after different forms of stress and at different cell cycle stages. (2000) (21)
Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers (2018) (20)
p53 and Metabolism: The GAMT Connection. (2009) (20)
DNA-binding properties of the p53 tumor suppressor protein. (1994) (20)
Unleashing the power of p 53 : lessons from mice and men (2006) (20)
Purification of SV-40 messenger RNA by hybridization to SV-40 DNA covalently bound to Sepharose. (1975) (19)
Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro (1990) (18)
Mutant p 53 cooperates with the SWI / SNF chromatin remodeling complex to regulate VEGFR 2 in breast cancer cells (2015) (18)
Noncoding RNAs: The Missing “Linc” in p53-Mediated Repression (2010) (18)
Effects of Cerebral Stimulation on the Biosynthesis in vitro of Nucleotides and RNA in Brain (1969) (18)
Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA (1995) (17)
E1A signaling to p53 involves the p19 tumor suppressor (1998) (17)
The linchpin? Pin1 meets p73. (2004) (17)
Down-Regulates CHK 1 through p 21 and the Retinoblastoma Protein (2001) (16)
Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs. (1989) (16)
Replication of damaged DNA in vitro is blocked by p53. (2003) (15)
Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen (1997) (15)
Developmental expression and co-localization of cyclin G1 and the B' subunits of protein phosphatase 2a in neurons. (1999) (15)
The C terminus of p 53 binds the N-terminal domain of MDM 2 (2010) (14)
STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma (2017) (14)
An excised SV40 intron accumulates and is stable in Xenopus laevis oocytes. (1988) (13)
Lysines in the tetramerization domain of p53 selectively modulate G1 arrest (2016) (13)
Cell-free translation of simian virus 40 16S and 19S L-strand-specific mRNA classes to simian virus 40 major VP-1 and minor VP-2 and VP-3 capsid proteins (1979) (13)
pBR322 DNA inhibits simian virus 40 gene expression in Xenopus laevis oocytes. (1987) (13)
Deconstructing nucleotide binding activity of the Mdm2 RING domain (2010) (12)
Replication of RNA viruses: structure of a 6 s RNA synthesized by the Q RNA polymerase. (1972) (12)
p 53 response element-directed transactivation . protein with p 53 leads to inhibition by HBx of Direct interaction of the hepatitis B virus HBx (1995) (11)
Functional consequences of the interactions of the p53 tumor suppressor protein and SV40 large tumor antigen. (1991) (11)
The Retinoblastoma Protein Alters the Phosphorylation State of Polyomavirus Large T Antigen in Murine Cell Extracts and Inhibits Polyomavirus Origin DNA Replication (1999) (11)
Regulation of simian virus 40 gene expression in Xenopus laevis oocytes (1985) (9)
DNA-Binding Properties ofSimian Virus 40T-Antigen Mutants Defective inViral DNA Replication (1983) (9)
GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma. (2022) (9)
Ribosomal protein L37 and the p53 network (2010) (8)
Regulation of p53 DNA Binding (2007) (8)
Expression in Human Normal and Tumor Tissues : Loss of p 73 Expression Is Associated with Tumor Progression in Bladder Cancer (2003) (8)
MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53 (2021) (7)
apoptosis . p 53-responsive genes cannot induce A mutant p 53 that discriminates between (1996) (7)
Mutational Analysis of the p 53 Core Domain L 1 Loop * (2006) (6)
Primary rat cells expressing a hybrid polyomavirus-simian virus 40 large T antigen have altered growth properties (1993) (6)
Unusual properties of a replication-defective mutant SV40 large T antigen. (1993) (6)
Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation (1992) (6)
Ribosomal protein L 37 and the p 53 network (2011) (6)
Dissimilar DNA binding by p53 in normal and tumor-derived cells (2011) (5)
The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation (2021) (5)
Mutant p53 succumbs to starvation (2013) (5)
p53, DNA damage, and NAD+ homeostasis (2014) (4)
Chromatin dysregulation by mutant p53 (2016) (4)
The p53-HAT connection (2012) (4)
The p 53 C Terminus Contr ols Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain Graphical Abstract Highlights (2015) (3)
Degradation Targeting MdmX for Mdm 2-Dependent MdmX at Serine 367 Activates p 53 by DNA Damage-Induced Phosphorylation of (2005) (3)
Baculovirus p 33 Binds Human p 53 and Enhances p 53-Mediated Apoptosis (1998) (3)
SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes. (1991) (3)
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity (2021) (3)
p53 Frameshift Mutations Couple Loss-of-Function with Unique Neomorphic Activities (2021) (2)
Abstract PL01-02: The two faces of p53: Tumor suppressor and oncogene (2014) (2)
Unfolding the roles of resveratrol in p53 regulation (2018) (2)
O-GlcNAc transferase regulates p21 protein levels and cell proliferation through the FoxM1–Skp2 axis in a p53-independent manner (2022) (2)
A subclass of polyomavirus middle tumor antigen binds to DNA cellulose (1986) (2)
Murine p53 inhibits the function but not the formation of SV40 T antigen hexamers and stimulates T antigen RNA helicase activity (2006) (2)
STXBP 4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma (2017) (2)
Characterization of an Immunologically Distinct Population of Simian Virus 40 Large Tumor Antigen (1987) (2)
An excised SV 40 intron accumulates and is stable in Xenopus laevis oocytes (2007) (1)
Advances in Brief p 53 , through p 21 ( WAF 1 / CIP 1 ) , Induces Cyclin Dl Synthesis 1 (2006) (1)
Cell-free translation of simian virus 40 early messenger RNA coding for viral (1)
Li-Fraumeni Syndrome-Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death. (2023) (1)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018) (1)
The Cell Free Translation of Purified Simian Virus 40 Messenger RNA (1975) (1)
Abstract 1289: The role of mutant p53-mediated mechanisms in modulating the tumor microenvironment and promoting lung metastasis (2023) (0)
Proceedings: Purification and translation of mRNA coding for SV40 proteins. (1975) (0)
Simian Virus40(SV40) T Antigen BindsSpecifically to Double-Stranded DNA butNottoSingle-Stranded DNA or DNA/RNAHybrids Containing theSV40Regulatory Sequences (1988) (0)
Transcriptional Regulation in Cancers and Metabolic Diseases (2015) (0)
TwoConditional tsAMutantSimian Virus40T Antigens Display MarkedDifferences inThermal Inactivation (1992) (0)
How Terri Grodzicker transformed Genes & Development (2023) (0)
Poster Viewing AbstractTP53 Status Predicts DNA Damage Response Pathways in Breast Cancer (2015) (0)
Discovering Transcription Factor Noncoding RNA Targets Using ChIP-Seq Analysis. (2020) (0)
Book Review:Advances in Viral Oncology. Volume 2: The Transformation-Associated Cellular p53 Protein. George Klein (1984) (0)
Replication Inhibits Polyomavirus Origin DNA Large T Antigen in Murine Cell Extracts and Phosphorylation State of Polyomavirus The Retinoblastoma Protein Alters the (2013) (0)
Pharmacological Targeting Of Mutant p53 Gain-of-Function Represses Mevalonate Pathway Of Cholesterol Biosynthesis And Sensitizes Tumor Cells To Radiation (2020) (0)
CATIONIC STIMULATION OF RNA SYNTHESIS IN RAT BRAIN CORTEX SLICES (1969) (0)
DNA-Binding Properties of Simian Virus 40 T-Antigen (2003) (0)
A non-canonical Hippo pathway represses the expression of ΔNp63 (2023) (0)
Abstract 2070: Stxbp4 suppresses APC/C mediated turnover of p63 and increases tumorigenicity and malignancy (2015) (0)
p53: Guardian of the Metabolome (2013) (0)
The C terminus of p53 binds the N-terminal domain of MDM2 (2011) (0)
232 INVITED Transcriptional regulation of apoptosis by the p53 tumor suppressor protein (2006) (0)
Correction: Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus (2018) (0)
TheReplication Functions ofPolyomavirus LargeTumor Antigen AreRegulated byPhosphorylation (1993) (0)
Abstract LB160: Mdm2 regulates metastasis and associated cellular processes through modulation of Sprouty4 in a p53-independent manner (2023) (0)
Abstract B014: Mutant p53-mediated CSF1/CSF1R signaling promotes tumor invasion and lung metastasis in esophageal squamous cell carcinoma (2023) (0)
Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH (2004) (0)
A nuclear pore component regulates select p53 target genes (2012) (0)
Signalling to the C-terminus of p53 (1997) (0)
p53 with a Human Touch Sue Armstrong p53: The Gene that Cracked the Cancer Code 2014 Bloomsbury Sigma New York, NY, USA 277 pp. $19.89 (2015) (0)
Replication of RNA viruses: Structure of a 6 s RNA synthesized by the Q? RNA polymerase*1 (1972) (0)
The Role of Mutant p53 Protein in Breast Cancer (1996) (0)
7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER (2006) (0)
TheDNA-Binding Properties ofPolyomavirus LargeT Antigen Are Altered byATP andOtherNucleotides (1991) (0)
Abstract 2421: Elucidation of CSF1 autocrine signaling mediated by mutant p53 in metastatic esophageal carcinoma (2022) (0)
636 Mechanisms by which the p53 tumour suppressor protein selects its target genes (2010) (0)
Retraction for Gonzalez et al., “p73α Regulation by Chk1 in Response to DNA Damage” (2017) (0)
Cell-Free Translation of Messenger RNA of Simian Virus 40: Synthesis of the Major Capsid. Protein (wheat-germ extracts/oligo(dT)-cellulose/gel electrophoresis/peptide analysis/ RNA DNA selective hybridization) (0)
Expression ofPolyomavirus LargeTAntigen byUsinga Baculovirus Vector (1987) (0)
A Subclass ofPolyomavirus Middle TumorAntigen Bindsto DNA Cellulose (1986) (0)
Molecular Cell Previews p 53 and Metabolism : The GAMT Connection (2009) (0)
Anything but simple: a phosphorylation-driven toggle within Brd4 triggers gene-specific transcriptional activation. (2013) (0)
Abstract 3429: Targeting gain-of-function of mutant p53 C-terminal and oligomerization domains to disrupt activated DNA replication in breast cancer (2020) (0)
Design and Testing of Bi-Functional, P-Loop-Targeted MDM2 Inhibitors (2006) (0)

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