Caroline Austin
#58,441
Most Influential Person Now
British molecular biologist
Caroline Austin's AcademicInfluence.com Rankings
Caroline Austinbiology Degrees
Biology
#3431
World Rank
#5248
Historical Rank
Cell Biology
#786
World Rank
#803
Historical Rank
Genetics
#1443
World Rank
#1545
Historical Rank
Molecular Biology
#2316
World Rank
#2351
Historical Rank
Download Badge
Biology
Caroline Austin's Degrees
- Bachelors Biology University of Oxford
Similar Degrees You Can Earn
Why Is Caroline Austin Influential?
(Suggest an Edit or Addition)According to Wikipedia, Caroline Ann Austin is a British molecular biologist known for her work on human DNA topoisomerase enzymes. She is a Professor of Molecular Biology at the Institute for Cell and Molecular Biosciences at Newcastle University Medical School.
Caroline Austin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. (2004) (262)
- Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development. (1992) (230)
- γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation (2007) (228)
- Eukaryotic DNA topoisomerase IIβ (1998) (222)
- The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. (2012) (181)
- Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives. (1992) (169)
- Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. (2005) (164)
- Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity (2012) (144)
- Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases. (1993) (141)
- Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique. (1998) (137)
- H2AX phosphorylation as a genotoxicity endpoint. (2009) (133)
- Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast. (1993) (128)
- The Novel Poly(ADP-Ribose) Polymerase Inhibitor, AG14361, Sensitizes Cells to Topoisomerase I Poisons by Increasing the Persistence of DNA Strand Breaks (2005) (111)
- Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents (2012) (103)
- Expression, Domain Structure, and Enzymatic Properties of an Active Recombinant Human DNA Topoisomerase IIβ (*) (1995) (96)
- The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells. (2010) (94)
- Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation. (1999) (93)
- NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform* (2008) (92)
- Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development (2000) (90)
- DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia (2008) (89)
- Deacetylase Activity Associates with Topoisomerase II and Is Necessary for Etoposide-induced Apoptosis* (2001) (87)
- The Role of Topoisomerase II in the Excision of DNA Loop Domains during Apoptosis* (2002) (77)
- Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIalpha (p170) and IIbeta (p180). (1996) (75)
- Eukaryotic DNA topoisomerase II beta. (1998) (72)
- The effect of terpenoid compounds on cytochrome P-450 levels in rat liver. (1988) (69)
- Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. (2007) (68)
- The coffee constituent chlorogenic acid induces cellular DNA damage and formation of topoisomerase I- and II-DNA complexes in cells. (2012) (65)
- TOP2B: The First Thirty Years (2018) (64)
- MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA (2012) (64)
- Cells lacking DNA topoisomerase IIβ are resistant to genistein (2007) (60)
- Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide. (2011) (59)
- Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2β construct allows the study of topoisomerase IIβ inhibitors in yeast. (1997) (57)
- Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53. (2000) (57)
- Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells (1990) (55)
- Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA (2019) (50)
- Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation. (1996) (47)
- Human topoisomerases and their roles in genome stability and organization (2022) (46)
- Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons (2014) (46)
- Poly(ADP-Ribose) Polymerases PARP1 and PARP2 Modulate Topoisomerase II Beta (TOP2B) Function During Chromatin Condensation in Mouse Spermiogenesis1 (2011) (44)
- Self-association of chromo domain peptides. (1997) (44)
- Threonine 1342 in Human Topoisomerase IIα Is Phosphorylated Throughout the Cell Cycle* (1996) (44)
- Nuclear distribution of human DNA topoisomerase IIbeta: a nuclear targeting signal resides in the 116-residue C-terminal tail. (1998) (39)
- Human DNA topoisomerase IIbeta binds and cleaves four-way junction DNA in vitro. (1999) (39)
- Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents (2003) (39)
- Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage. (2000) (37)
- Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells. (2002) (36)
- Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells (2015) (36)
- Differences in the longevity of topo IIα and topo IIβ drug-stabilized cleavable complexes and the relationship to drug sensitivity (2004) (34)
- Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II (2016) (34)
- Mutations in topoisomerase IIβ result in a B cell immunodeficiency (2019) (33)
- Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon (2015) (32)
- Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity. (1996) (31)
- Cells lacking DNA topoisomerase II beta are resistant to genistein. (2007) (31)
- Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms α and β (1996) (30)
- The Impact of the C-Terminal Domain on the Interaction of Human DNA Topoisomerase II α and β with DNA (2011) (29)
- An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay. (2011) (28)
- An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. (2000) (27)
- Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication. (1999) (27)
- Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha. (2000) (26)
- Poly(ADP-ribose) Metabolism Is Essential for Proper Nucleoprotein Exchange During Mouse Spermiogenesis1 (2011) (25)
- The Impact of the Human DNA Topoisomerase II C-Terminal Domain on Activity (2008) (25)
- Human DNA topoisomerase IIalpha-dependent DNA cleavage and yeast cell killing by anthracycline analogues. (1998) (25)
- Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy (2017) (25)
- Salicylate, a Catalytic Inhibitor of Topoisomerase II, Inhibits DNA Cleavage and Is Selective for the α Isoform (2014) (24)
- Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death. (2013) (24)
- DNA binding and intercalation by novel porphyrins: role of charge and substituents probed by DNase I footprinting and topoisomerase I unwinding (1990) (24)
- Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. (2011) (23)
- Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining). (2000) (23)
- Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations (2019) (22)
- Quantitation of DNA topoisomerase IIα and β in human leukaemia cells by immunoblotting (2000) (21)
- Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity. (2004) (20)
- Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer. (2003) (20)
- Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules. (2015) (19)
- Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide (2010) (19)
- Mutation P732L in Human DNA Topoisomerase IIβ Abolishes DNA Cleavage in the Presence of Calcium and Confers Drug Resistance (2006) (19)
- A high-throughput fluorescence anisotropy-based assay for human topoisomerase II β-catalyzed ATP-dependent supercoiled DNA relaxation. (2014) (18)
- Plant and Human MORC Proteins Have DNA-Modifying Activities Similar to Type II Topoisomerases, but Require One or More Additional Factors for Full Activity. (2017) (18)
- DNA topoisomerases: enzymes that change the shape of DNA. (1990) (18)
- cDNA library protocols (1996) (17)
- Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia? (2012) (17)
- Poly(ADP-ribose) Metabolism Is Essential for Proper Nucleoprotein Exchange During Mouse Spermiogenesis 1 (2011) (16)
- The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1 (2014) (15)
- Selenite induces topoisomerase I and II‐DNA complexes in K562 leukemia cells (2008) (15)
- Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes (2018) (15)
- Brief Reports: Controlling the Survival of Human Pluripotent Stem Cells by Small Molecule‐Based Targeting of Topoisomerase II Alpha (2015) (15)
- Mutation E522K in human DNA topoisomerase IIbeta confers resistance to methyl N-(4'-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4'-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide. (2004) (15)
- mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity (2006) (14)
- Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells. (2006) (14)
- Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases (2009) (14)
- Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta. (1996) (13)
- Kinetic analysis of human topoisomerase IIα and β DNA binding by surface plasmon resonance (2003) (13)
- Carbamate analogues of amsacrine active against non-cycling cells: relative activity against topoisomerases IIα and β (1999) (13)
- DNA supercoiling and relaxation by ATP-dependent DNA topoisomerases. (1992) (12)
- Quantitation of DNA topoisomerase IIalpha and beta in human leukaemia cells by immunoblotting. (2000) (11)
- Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability. (2002) (11)
- Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death. (2012) (10)
- Development and properties of an etoposide-resistant human leukaemic CCRF-CEM cell line. (1990) (10)
- Nick-forming sequences may be involved in the organization of eukaryotic chromatin into ∼50 kbp loops (2005) (10)
- Histone deacetylase inhibition redistributes topoisomerase IIb from heterochromatin to euchromatin (2011) (9)
- Does oxidative damage contribute to the generation of leukemia? (2009) (8)
- Differential Selection of Acridine Resistance Mutations in Human DNA Topoisomerase IIβ Is Dependent on the Acridine Structure (2007) (8)
- Nick-forming sequences may be involved in the organization of eukaryotic chromatin into approximately 50 kbp loops. (2006) (8)
- Structure and partial amino acid sequence of calf thymus DNA topoisomerase II: comparison with other type II enzymes. (1990) (7)
- Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes (2020) (7)
- Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin (2002) (6)
- Characterisation of the roles of Topoisomerase I and II in the mechanism of action of novel anti-tumour agents XR11576 (MLN576) and XR5944 (MLN944) (2002) (6)
- A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents (2019) (6)
- Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance. (2003) (5)
- The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison (2019) (5)
- Structure and expression of genes coding for components of the cytochrome P-450-mediated mono-oxygenase. (1987) (5)
- Visualization and Quantification of Topoisomerase-DNA Covalent Complexes Using the Trapped in Agarose Immunostaining (TARDIS) Assay. (2018) (5)
- Biochemical and immunological characterization of mammalian DNA topoisomerase II (1989) (5)
- A Role for VCP/p97 in the Processing of Drug-Stabilized TOP2-DNA Covalent Complexes (2021) (4)
- Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions. (2021) (4)
- Inhibition of DNA Gyrase: Bacterial Sensitivity and Clinical Resistance to 4-Quinolones (1989) (3)
- Carbamate analogues of amsacrine active against non-cycling cells: relative activity against topoisomerases IIalpha and beta. (1999) (3)
- TOP2B's contributions to transcription. (2021) (3)
- Two type I topoisomerases maintain DNA topology in human mitochondria (2022) (2)
- TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells (2022) (2)
- A Survey of Final-year Undergraduate Laboratory Projects in Biochemistry and Related Degrees in Great Britain. (1997) (2)
- 103 Site-directed mutagenesis of human DNA topoisomerase IIβ (1997) (1)
- In vitro micronucleus assay –increase in binucleated cells in mononucleate assay (2010) (1)
- Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes (2021) (1)
- A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193 (2022) (1)
- Index to Titles and Authors/Editors of Books Reviewed (1998) (1)
- Screening cDNA libraries by hybridization with double-stranded DNA probes and oligonucleotides. (1997) (1)
- Site-directed mutagenesis of human DNA topoisomerase II beta. (1997) (0)
- Phillips Structure and expression of genes coding for components of the cytochrome P-450-mediated mono-ox ygenase (2009) (0)
- Bioinformatic analysis of topoisomerase II binding sites (2007) (0)
- The effect of quinolones on human type II topoisomerases using the Trapped in AgaRose DNA ImmunoStaining (TARDIS) assay (2010) (0)
- Model for generation of chromosomal translocations in leukaemia (2009) (0)
- Topoisomerase II Chromatin Immunoprecipitation. (2018) (0)
- 26. Precommitment gene expression changes during mouse erythroleukemia cell differentiation and their relationship to c-myc (1992) (0)
- Evaluating the gamma H2AX focus assay to assess genotoxicity (2009) (0)
- Topoisomerase II alpha sites of occupancy on human chromosome 22 (2012) (0)
- Cell cycle-dependent expression and subcellular localization of human barren-1 (HCAP-H). (1999) (0)
- Isoform α Specifically Targets the NK 314 , a Topoisomerase II Inhibitor That and Chromosome Dynamics : DNA : Replication , Repair (2008) (0)
- in Yeast α Human DNA Topoisomerase II Topoisomerases : Expression of a Functional Recombinant Use of Yeast in the Study of Anticancer Drugs Targeting DNA Updated (2006) (0)
- Abstracts of the 33 rd Annual Meeting of the United Kingdom Environmental Mutagen Society, 12 th - 14 th July 2010 at the University of Derby, UK. Photo geno toxicity – science without application? (2010) (0)
- Investigations into kinase associated genotoxicity (2009) (0)
- SHORT REPORT Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells (2008) (0)
- Kinases as therapeutic agents: a new potential genetic toxicology liability (2009) (0)
- Identifying drug-resistant mutations in human topoisomerase II beta using a forced molecular evolution approach (2004) (0)
- Human topoisomerase II alpha bound to DNA (2012) (0)
- Use of genotoxicity endpoints to determine the genotoxic potential of PI3-kinase inhibitors (2010) (0)
- CONTENTS (2006) (0)
- DNA fragility at the KMT2A/MLL locus: insights from old and new technologies (2023) (0)
- Brief communication Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells (2006) (0)
This paper list is powered by the following services:
Other Resources About Caroline Austin
What Schools Are Affiliated With Caroline Austin?
Caroline Austin is affiliated with the following schools:
