Carolyn Cohen
Biologist
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Biology
Carolyn Cohen's Degrees
- Bachelors Biology University of California, Berkeley
- Masters Ecology Stanford University
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(Suggest an Edit or Addition)According to Wikipedia, Carolyn Cohen was an American biologist and biophysicist. She was a Fellow of the American Academy of Arts and Sciences. Early life and education Carolyn Cohen was born June 18th, 1929 to parents Anna and Philip Cohen. After Cohen's father died in 1939, she credited his lawyer Samuel Sumner Goldberg for mentoring her and nurturing her curiosity. Cohen attended Joan of Arc Junior High School, then the selective Hunter College High School. After rejections from McGill University and Barnard College, Cohen's French teacher urged her to apply to Bryn Mawr College, where she was accepted with a full-tuition scholarship. In the summer of 1949, Cohen took a job in the kitchen of the Marine Biological Laboratory at Woods Hole, MA. There she met Shinya Inoué, worked for Otto Schmitt, and attended a lecture by Dorothy Wrinch that she later credited with stimulating her career interest in protein structures. Cohen completed her Bachelor of Arts in Biology and Physics from Bryn Mawr in 1950, graduating summa cum laude. She then moved to Massachusetts Institute of Technology, for a PhD under the supervision of Richard S. Bear. There she worked on the structure of collagen and other helically structured proteins, completing her degree in 1954.
Carolyn Cohen's Published Works
Published Works
- Crystal Structure of a Vertebrate Smooth Muscle Myosin Motor Domain and Its Complex with the Essential Light Chain Visualization of the Pre–Power Stroke State (1998) (632)
- α‐Helical coiled coils and bundles: How to design an α‐helical protein (1990) (584)
- α-Helical coiled coils — a widespread motif in proteins (1986) (340)
- Atomic Structure of Scallop Myosin Subfragment S1 Complexed with MgADP A Novel Conformation of the Myosin Head (1999) (321)
- Three conformational states of scallop myosin S1. (2000) (308)
- Streptococcal M protein: alpha-helical coiled-coil structure and arrangement on the cell surface. (1981) (308)
- Studies on the structure of myosin. (1962) (305)
- Tropomyosin crystal structure and muscle regulation. (1986) (297)
- Paramyosin and the filaments of molluscan "catch" muscles. II. Native filaments: isolation and characterization. (1971) (275)
- Structure of the regulatory domain of scallop myosin at 2.8 Ä resolution (1994) (267)
- Tropomyosin: crystal structure, polymorphism and molecular interactions. (1969) (256)
- Heptad breaks in α‐helical coiled coils: Stutters and stammers (1996) (239)
- Deciphering the design of the tropomyosin molecule (2001) (234)
- A model for fibrinogen: domains and sequence. (1985) (232)
- Muscle Contraction (1962) (229)
- Structure of co-crystals of tropomyosin and troponin (1987) (216)
- Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation. (1996) (201)
- OPTICAL ROTATION AND HELICAL POLYPEPTIDE CHAIN CONFIGURATION IN α-PROTEINS (1957) (191)
- Paramyosin and the filaments of molluscan "catch" muscles. I. Paramyosin: structure and assembly. (1971) (190)
- A tropomyosin-like protein from human platelets. (1972) (185)
- The crystal structure of modified bovine fibrinogen. (2000) (181)
- X-ray diffraction evidence for α-helical coiled-coils in native muscle (1963) (168)
- Troponin and its interactions with tropomyosin. An electron microscope study. (1982) (164)
- A Conformation-dependent Cotton Effect in α-Helical Polypeptides and Proteins1,2 (1961) (158)
- Alpha-helical coiled coils: more facts and better predictions. (1994) (154)
- Electron microscopy of thin filaments decorated with a Ca2+-regulated myosin. (1980) (151)
- Structure of the mid-region of tropomyosin: bending and binding sites for actin. (2005) (151)
- A 29 residue region of the sarcomeric myosin rod is necessary for filament formation. (1997) (146)
- Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily. (1997) (141)
- Crystal structure and molecular interactions of tropomyosin (1979) (134)
- Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features (2006) (134)
- Alpha-helical coiled coils and bundles: how to design an alpha-helical protein. (1990) (132)
- Light meromyosin fraction I: A helical molecule from myosin (1960) (120)
- Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. (2007) (113)
- Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function. (2005) (111)
- Role of proline in polypeptide chain configuration of proteins. (1957) (107)
- Tropomyosin Paracrystals Formed by Divalent Cations (1966) (107)
- Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin. (1995) (104)
- Crystallographic findings on the internally uncoupled and near-rigor states of myosin: Further insights into the mechanics of the motor (2002) (101)
- A model of Ca(2+)-free calmodulin binding to unconventional myosins reveals how calmodulin acts as a regulatory switch. (1996) (101)
- Axial Period of Fibrinogen and Fibrin (1963) (99)
- Heptad breaks in alpha-helical coiled coils: stutters and stammers. (1996) (96)
- A model from electron microscopy for the molecular structure of fibrinogen and fibrin (1981) (93)
- The crystal structure of the C-terminal fragment of striated-muscle α-tropomyosin reveals a key troponin T recognition site (2002) (93)
- Proteolytic degradation of myosin and the meromyosins by a water-insoluble polyanionic derivative of trypsin: properties of a helical subunit isolated from heavy meromyosin. (1967) (90)
- Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head. (2003) (86)
- Visualization of an unstable coiled coil from the scallop myosin rod (2003) (80)
- Analysis of the three-alpha-helix motif in the spectrin superfamily of proteins. (1992) (79)
- Myosin rod phosphorylation and the catch state of molluscan muscles. (1987) (76)
- The protein switch of muscle contraction. (1975) (75)
- Motions of tropomyosin. Crystal as metaphor. (1980) (75)
- Diversity of cross-bridge configurations in invertebrate muscles (1975) (74)
- Bepridil opens the regulatory N-terminal lobe of cardiac troponin C. (2000) (71)
- Assembly of myosin. (1971) (70)
- Microtubule structure at 18 A resolution. (1987) (69)
- Microtubule structure at low resolution by x-ray diffraction. (1977) (69)
- Troponin subunit interactions (1973) (68)
- Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-Å resolution (2001) (67)
- Actin filaments in muscle: pattern of myosin and tropomyosin/troponin attachments. (1978) (64)
- Schistosome surface spines are "crystals" of actin (1982) (63)
- VITROSIN: A MEMBER OF THE COLLAGEN CLASS (1955) (62)
- Isolation and characterization of a lysine-specific protease from Pseudomonas aeruginosa. (1986) (62)
- A conserved C-terminal assembly region in paramyosin and myosin rods. (1998) (61)
- Tropomyosin-Troponin Assembly (1973) (60)
- Tropomyosin crystal dynamics. (1972) (60)
- Structure of tropomyosin at 9 angstroms resolution. (1992) (57)
- Pitch diversity in α‐helical coiled coils (1993) (57)
- A new myosin fragment: visualization of the regulatory domain (1984) (56)
- X-ray diffraction from microtubules. (1971) (55)
- Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding (2004) (54)
- OPTICAL ROTATION AND HELICAL POLYPEPTIDE CHAIN CONFIGURATION IN COLLAGEN AND GELATIN (1955) (52)
- Matching molecules in the catch mechanism. (1982) (50)
- Segments from myosin rods. (1970) (49)
- Fibrinogen structure in projection at 18 A resolution. Electron density by co-ordinated cryo-electron microscopy and X-ray crystallography. (1991) (48)
- Cross-bridge arrangements in Limulus muscle. (1974) (48)
- Rod phosphorylation favors folding in a catch muscle myosin. (1987) (47)
- Polymorphism in fibrinogen aggregates. (1966) (47)
- α-Helical coiled-coil structures of Trypanosoma brucei variable surface glycoproteins (1984) (46)
- Amino acid sequence and structural repeats in schistosome paramyosin match those of myosin (1987) (46)
- Microcrystals of a Modified Fibrinogen (1972) (46)
- Segments from vertebrate smooth muscle myosin rods. (1971) (45)
- Optical Rotation and Polypeptide Chain Configuration in Proteins (1955) (44)
- HELICAL POLYPEPTIDE CHAIN CONFIGURATION IN COLLAGEN1 (1953) (42)
- X‐RAY PATTERNS FROM MICROTUBULES * (1975) (40)
- Crystalline states of a modified fibrinogen. (1977) (40)
- Molecular polarity in tropomyosin-troponin T co-crystals. (1997) (39)
- An X-ray diffraction study of F-actin. (1956) (39)
- Crystals of modified fibrinogen: size, shape and packing of molecules. (1978) (37)
- THE STRUCTURE OF FIBRINOGEN AND FIBRIN: II. ARCHITECTURE OF THE FIBRIN CLOT * (1983) (36)
- Structure of myosin/paramyosin filaments from a molluscan smooth muscle. (1983) (36)
- A calcineurin‐like phosphatase is required for catch contraction (1992) (34)
- Paramyosin: Molecular Length and Assembly (1969) (31)
- The on-off switch in regulated myosins: different triggers but related mechanisms. (2009) (31)
- THE STRUCTURE OF FIBRINOGEN AND FIBRIN: I. ELECTRON MICROSCOPY AND X‐RAY CRYSTALLOGRAPHY OF FIBRINOGEN * (1983) (30)
- Paracrystalline Forms of Fibrinogen (1963) (28)
- Structure of the regulatory domain of scallop myosin at 2.8 Å resolution (1993) (25)
- Why fibrous proteins are romantic. (1998) (24)
- Occurrence of three red blood cell antigens in rabbit as the result of interaction of two genes. (1956) (24)
- Crystallisation of a modified fibrinogen (1974) (23)
- Visualizing key hinges and a potential major source of compliance in the lever arm of myosin (2010) (23)
- Electron microscopy of cross-linked scallop myosin. (1985) (21)
- Domains, motions and regulation in the myosin head (1988) (21)
- X-ray diffraction evidence for alpha-helical coiled-coils in native muscle. (1963) (21)
- Spikes and fimbriae: alpha-helical proteins form surface projections on microorganisms. (1981) (20)
- Multisite association by recombinant proteins can enhance binding selectivity. Preferential removal of immune complexes from serum by immobilized truncated FB analogues of the B domain from staphylococcal protein A. (1992) (17)
- Cell architecture and morphogenesis I. The cytoskeletal proteins (1979) (16)
- Protein assemblies and cell form (1977) (14)
- Structural models for the regulatory switch of Myosin. (1986) (14)
- Changes in crossbridge attachment in a myosin-regulated muscle (1978) (14)
- Pitch diversity in alpha-helical coiled coils. (1993) (13)
- An unstable head-rod junction may promote folding into the compact off-state conformation of regulated myosins. (2008) (12)
- Phosphorylatable serine residues are located in a non-helical tailpiece of a catch muscle myosin (1988) (12)
- Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy. (1987) (11)
- Structural studies of tropomyosin by cryoelectron microscopy and x-ray diffraction. (1991) (11)
- Coiled-coil packing in spermine-induced tropomyosin crystals. A comparative study of three forms. (1994) (10)
- Two-stranded alpha-helical coiled-coils of fibrous proteins: theoretical analysis of supercoil formation. (1986) (10)
- A new crystal form of tropomyosin. Preliminary X-ray diffraction analysis. (1987) (9)
- Segments from modified human fibrinogen. (1980) (9)
- Myosin binding to actin. Structural analysis using myosin fragments. (1987) (9)
- Structural studies on uterine myosin. (1961) (9)
- X-Ray Solution Scattering of Squid Heavy Meromyosin: Strengthening the Evidence for an Ancient Compact off State (2013) (8)
- SCALLOP MYOSIN REGULATORY DOMAIN (1996) (8)
- New perspectives on catch. (1988) (7)
- Purification, crystallization and preliminary X-ray crystallographic analysis of squid heavy meromyosin. (2013) (7)
- Crystal structure of a phosphorylated light chain domain of scallop smooth-muscle myosin. (2011) (5)
- Protein switches in muscle contraction. (1980) (4)
- Cell architecture and morphogenesis II. Examples in embryology (1979) (4)
- The Molecular Structure Of Fibrinogen And The Architecture Of The Fibrin Clot: A Model From Electron Microscopy (1981) (3)
- The Lotmar-Picken Substance: Taurine (1958) (2)
- Microtubule structure at 18 angstrom resolution by x ray diffraction (1985) (2)
- Erratum: Bepridil opens the regulatory N-terminal lobe of cardiac troponin C (Proceedings of the National Academy of Sciences of the United States of America (May 9, 2000) 97:10 (5140-5145)) (2000) (2)
- Good times with don caspar. (1998) (1)
- Phosphorylated peptides occur in a non-helical portion of the tail of a catch muscle myosin (1987) (1)
- The helical configuration of the polypeptide chains in collagen (1954) (1)
- THE CRYSTAL STRUCTURE OF MODIFIED BOVINE FIBRINOGEN (AT ~4 ANGSTROM RESOLUTION) (2000) (1)
- Structure of tropomyosin's mid-region: bending and binding sites for actin (2006) (1)
- MYOSIN-PARAMYOSIN PHOSPHORYLATION IN MOLLUSCAN MUSCLES (1988) (1)
- Design and Function of Fibrous Proteins (2008) (1)
- TROPOMYOSIN CRYSTAL STRUCTURE AND MUSCLE REGULATION. APPENDIX. CONSTRUCTION OF AN ATOMIC MODEL FOR TROPOMYOSIN AND IMPLICATIONS FOR INTERACTIONS WITH ACTIN (1987) (1)
- Seeing and Knowing in Structural Biology (2007) (1)
- Book Review:Progress in Microscopy. International Series of Monographs on Pure and Applied Biology. Volume 9. M. Francon (1963) (0)
- VISUALIZING AN UNSTABLE COILED COIL: THE CRYSTAL STRUCTURE OF AN N-TERMINAL SEGMENT OF THE SCALLOP MYOSIN ROD (2003) (0)
- APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL (1997) (0)
- What can Crystallographic Analysis tell us About Fibrinogen? (1979) (0)
- The crystal structure of rigor like squid myosin S1 in the absence of nucleotide (2008) (0)
- Mrs. Professor (2011) (0)
- SCALLOP MYOSIN S1-ADP-p-PDM IN THE ACTIN-DETACHED CONFORMATION (2002) (0)
- The Application of X-Ray Diffraction for Glass Batch Homogeneity Determination (1981) (0)
- The crystal structure of squid myosin S1 in the presence of SO4 2 (2008) (0)
- Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution (2002) (0)
- SMOOTH MUSCLE MYOSIN MOTOR DOMAIN COMPLEXED WITH MGADP.ALF4 (1998) (0)
- What can the regulatory domain of myosin tell us about regulation (1996) (0)
- Calcium-bound Scallop Myosin Regulatory Domain (Lever Arm) with Reconstituted Complete Light Chains (2009) (0)
- Phosphorylated Light Chain Domain of Scallop smooth Muscle Myosin (2011) (0)
- Crystal structure of Squid Mg.ADP myosin S1 (2007) (0)
- Structure of the spectrin superfamily: A three‐α‐helix motif (2008) (0)
- SCALLOP MYOSIN S1-ATPgammaS-p-PDM IN THE ACTIN-DETACHED CONFORMATION (2002) (0)
- SCALLOP MYOSIN IN THE NEAR RIGOR CONFORMATION (2002) (0)
- SMOOTH MUSCLE MYOSIN MOTOR DOMAIN-ESSENTIAL LIGHT CHAIN COMPLEX WITH MGADP.ALF4 BOUND AT THE ACTIVE SITE (1998) (0)
- Crystal structure of the N-terminal region of the scallop myosin rod, monoclinic (P21) form (2008) (0)
- Crystal structure of Rigor-like Squid Myosin S1 (2007) (0)
- Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin (2011) (0)
- CRYSTAL STRUCTURE OF CALCIUM-SATURATED (3CA2+) CARDIAC TROPONIN C COMPLEXED WITH THE CALCIUM SENSITIZER BEPRIDIL AT 2.15 A RESOLUTION (2000) (0)
- NUCLEOTIDE-FREE SCALLOP MYOSIN S1-NEAR RIGOR STATE (2000) (0)
- Structure of apo-calmodulin bound to unconventional myosin V (2006) (0)
- MYOSIN DIGESTED BY PAPAIN (1999) (0)
- Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation (2009) (0)
- FOUR CALCIUM TNC (1998) (0)
- α-Helices in proteins: Strategies for detecting and analysing coiled-coil motifs (1991) (0)
- Letter: Troponin subunit interactions. (1973) (0)
- Structure of Scallop myosin S1 reveals a novel nucleotide conformation (2004) (0)
- Matching molecules in the catch mechanism ( muscle / moliusc / paramyosin / myosin / phosphorylation ) (0)
- SCALLOP MYOSIN S1 COMPLEXED WITH MGADP:VANADATE-TRANSITION STATE (2000) (0)
- [Relaxation system in platelets]. (1972) (0)
- Structure of nucleotide-free scallop myosin S1 (2004) (0)
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