Carolyn Slayman
American geneticist
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Biology
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(Suggest an Edit or Addition)According to Wikipedia, Carolyn Walch Slayman was an American geneticist. She was on the faculty of the Yale School of Medicine, where she was appointed Sterling Professor in 1991. On March 11, 1937, she was born in Portland, ME and would become the first scientist in her family. In 1958, she graduated from Swarthmore College with highest honors in biology and chemistry and was elected to Phi Beta Kappa. She began graduate school at Johns Hopkins University to study biochemistry but transferred to Rockefeller University in 1959 where she was the only woman in her class. In 1963, she earned her doctorate in biochemical genetics. She was a postdoctoral fellow in membrane biochemistry at Cambridge University. After a short time stint as an assistant professor at Case Western Reserve, she joined the Yale departments of microbiology and physiology in 1967.
Carolyn Slayman's Published Works
Published Works
- The Sequence of the Human Genome (2001) (6572)
- The proton-translocating ATPase of the fungal plasma membrane. (1981) (422)
- Effects of inhibitors on the plasma membrane and mitochondrial adenosine triphosphatases of Neurospora crassa. (1978) (234)
- Depolarization of the plasma membrane of Neurospora during active transport of glucose: evidence for a proton-dependent cotransport system. (1974) (205)
- The effects of vanadate on the plasma membrane ATPase of Neurospora crassa. (1979) (191)
- Maturation of the yeast plasma membrane [H+]ATPase involves phosphorylation during intracellular transport (1991) (187)
- Cyanide-Resistant Respiration in Neurospora crassa (1971) (172)
- POTASSIUM TRANSPORT IN NEUROSPORA. I. INTRACELLULAR SODIUM AND POTASSIUM CONCENTRATIONS, AND CATION REQUIREMENTS FOR GROWTH. (1964) (139)
- Expression of the yeast plasma membrane [H+]ATPase in secretory vesicles. A new strategy for directed mutagenesis. (1991) (139)
- Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H(+)-ATPase. (2000) (134)
- Characterization of plasma membrane adenosine triphosphatase of Neurospora crassa. (1977) (119)
- Tandem Phosphorylation of Ser-911 and Thr-912 at the C Terminus of Yeast Plasma Membrane H+-ATPase Leads to Glucose-dependent Activation* (2007) (117)
- Pharmacologically different Na/H antiporters on the apical and basolateral surfaces of cultured porcine kidney cells (LLC-PK1). (1988) (117)
- Amino acid sequence of the plasma membrane ATPase of Neurospora crassa: deduction from genomic and cDNA sequences. (1986) (115)
- Purification and characterization of the plasma membrane ATPase of Neurospora crassa. (1981) (104)
- Isolation of an ion channel gene from Arabidopsis thaliana using the H5 signature sequence from voltage‐dependent K+ channels (1996) (95)
- Measurement of Membrane Potentials in Neurospora (1962) (88)
- Biogenesis and function of the yeast plasma-membrane H(+)-ATPase. (2000) (86)
- H+/ATP stoichiometry of proton pumps from Neurospora crassa and Escherichia coli. (1986) (82)
- Net Uptake of Potassium in Neurospora Exchange for sodium and hydrogen ions (1968) (82)
- Electrogenic H+ translocation by the plasma membrane ATPase of Neurospora. Studies on plasma membrane vesicles and reconstituted enzyme. (1984) (80)
- The electron transport components of wild type and poky strains of Neurospora crassa. (1972) (75)
- Transcriptional regulation by glucose of the yeast PMA1 gene encoding the plasma membrane H+‐ATPase (1993) (72)
- Oxidative phosphorylation in Neurospora mitochondria. Studies on wild type, poky, and chloramphenicol-induced wild type. (1972) (67)
- The Yeast Pma1 Proton Pump: a Model for Understanding the Biogenesis of Plasma Membrane Proteins* (2001) (66)
- Electron transport in Neurospora mitochondria. Studies on wild type and poky. (1972) (66)
- Deoxyglucose-resistant mutants of Neurospora crassa: isolation, mapping, and biochemical characterization (1989) (63)
- Potassium Transport in Neurospora (1970) (60)
- Conformational changes of yeast plasma membrane H(+)-ATPase during activation by glucose: role of threonine-912 in the carboxy-terminal tail. (2005) (53)
- Stimulation of bumetanide‐sensitive K+ transport in Swiss 3T3 fibroblasts by serum and mitogenic hormones (1985) (52)
- Isolation and characterization of plasma membranes from wild type Neurospora crassa. (1981) (52)
- Phosphate transport in Neurospora. Kinetic characterization of a constitutive, low-affinity transport system. (1974) (51)
- Phosphorylation Region of the Yeast Plasma-membrane H+-ATPase (1998) (48)
- Na+/H+ exchanger activity in the pig kidney epithelial cell line, LLC-PK1: inhibition by amiloride and its derivatives. (1985) (47)
- Potassium transport in neurospora. II. Measurement of steady-state potassium fluxes. (1965) (46)
- Phosphate transport in Neurospora. Derepression of a high-affinity transport system during phosphorus starvation. (1975) (44)
- The amino and carboxyl termini of the Neurospora plasma membrane H+-ATPase are cytoplasmically located. (1989) (44)
- THE ADENOSINE-TRIPHOSPHATASE SYSTEM RESPONSIBLE FOR CATION TRANSPORT IN ELECTRIC ORGAN: EXCLUSION OF PHOSPHOLIPIDS AS INTERMEDIATES. (1965) (44)
- Quality Control in the Yeast Secretory Pathway (2002) (42)
- Alanine-scanning Mutagenesis along Membrane Segment 4 of the Yeast Plasma Membrane H+-ATPase EFFECTS ON STRUCTURE AND FUNCTION* (1996) (42)
- Inhibition of the plasma membrane [H+]-ATPase of Neurospora crassa by N-ethylmaleimide. Protection by nucleotides. (1982) (41)
- cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cells. (1991) (40)
- Kinetics and pH-dependence of glycine-proton symport in Saccharomyces cerevisiae. (1984) (38)
- Potassium transport in Neurospora. 3. Isolation of a transport mutant. (1965) (38)
- Substitutions of Aspartate 378 in the Phosphorylation Domain of the Yeast PMA1 H+-ATPase Disrupt Protein Folding and Biogenesis* (1998) (38)
- Site-directed Mutagenesis of the Yeast PMA1 H+-ATPase STRUCTURAL AND FUNCTIONAL ROLE OF CYSTEINE RESIDUES (*) (1995) (37)
- Molecular properties of the fungal plasma-membrane [H+]-ATPase (1989) (37)
- Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor (2016) (37)
- Modification of the Neurospora crassa plasma membrane [H+]-ATPase with N,N'-dicyclohexylcarbodiimide. (1983) (37)
- Characterization of an essential arginine residue in the plasma membrane H+-ATPase of Neurospora crassa. (1986) (35)
- Evidence for a Salt Bridge between Transmembrane Segments 5 and 6 of the Yeast Plasma-membrane H+-ATPase* (1998) (34)
- Mutagenesis of conserved residues in the phosphorylation domain of the yeast plasma membrane H(+)-ATPase. Effects on structure and function. (1993) (33)
- Effects of Mg2+ ions on the plasma membrane [H+]-ATPase of Neurospora crassa. II. Kinetic studies. (1983) (32)
- [14C]N-ethylmaleimide labeling of the plasma membrane [H+]-ATPase of Neurospora crassa. (1983) (31)
- Increased Na(+)-H+ antiporter activity in apical membrane vesicles from mutant LLC-PK1 cells. (1991) (30)
- Identification of tryptic cleavage sites for two conformational states of the Neurospora plasma membrane H+-ATPase. (1988) (29)
- Vanadate-Resistant Mutants of Neurospora crassa Are Deficient in a High-Affinity Phosphate Transport System (1983) (29)
- Transmembrane Segments of the P‐Type Cation‐Transporting ATPases A Comparative Study a (1989) (29)
- The Genetic Control of Membrane Transport (1974) (28)
- Generation of adenosine triphosphate in cytochrome-deficient mutants of Neurospora. (1975) (28)
- The fluorescein isothiocyanate-binding site of the plasma-membrane H+-ATPase of Neurospora crassa. (1988) (27)
- Isolation of transport-competent secretory vesicles from Saccharomyces cerevisiae. (1997) (25)
- Structure-Function Relationships in Membrane Segment 5 of the Yeast Pma1 H+-ATPase* (1998) (25)
- Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcript. (1991) (25)
- Functional Role of Charged Residues in the Transmembrane Segments of the Yeast Plasma Membrane H+-ATPase* (2000) (22)
- Effect of Pyrrolnitrin on Electron Transport and Oxidative Phosphorylation in Mitochondria Isolated from Neurospora crassa (1972) (21)
- Structure and Function of the Yeast Plasma‐Membrane H+‐ATPase a (1992) (21)
- Genetic alterations in potassium transport in L cells. (1978) (21)
- Location of a dicyclohexylcarbodiimide-reactive glutamate residue in the Neurospora crassa plasma membrane H+-ATPase. (1987) (20)
- Reduction of K+ efflux in cultured mouse fibroblasts, by mutation or by diuretics, permits growth in K+-deficient medium. (1981) (20)
- C-Terminal Truncations of the Saccharomyces cerevisiae PMA1 H+-ATPase Have Major Impacts on Protein Conformation, Trafficking, Quality Control, and Function (2013) (20)
- Identification and purification of a renal amiloride-binding protein with properties of the Na+-H+ exchanger. (1989) (20)
- Plasma-Membrane and Related ATPases (1996) (20)
- Tritium suicide selection of mammalian cell mutants defective in the transport of neutral amino acids. (1977) (20)
- Genetic regulation of phosphate transport system II in Neurospora. (1975) (20)
- Rapid changes in bidirectional K+ fluxes preceding DMSO‐induced granulocytic differentiation of HL‐60 human leukemic cells (1984) (20)
- Reactive Cysteines of the Yeast Plasma-Membrane H+-ATPase (PMA1) (1997) (19)
- Effects of Mg2+ ions on the plasma membrane [H+]-ATPase of Neurospora crassa. I. Inhibition by N-ethylmaleimide and trypsin. (1983) (19)
- The uptake of L-glutamic acid in a normal mouse lymphocyte line and in a transport mutant. (1978) (18)
- Folding and intracellular transport of the yeast plasma-membrane H(+)-ATPase: effects of mutations in KAR2 and SEC65. (1993) (17)
- Mutagenesis of the yeast plasma membrane H(+)-ATPase. A novel expression system. (1992) (17)
- Furosemide‐sensitive potassium efflux in cultured mouse fibroblasts (1984) (17)
- Mitochondrial adenosine triphosphatase of wild-type and poky Neurospora crassa (1978) (17)
- Isolation and characterization of a CHO amino acid transport mutant resistant to melphalan (l-phenylalanine mustard) (1984) (17)
- Mode of action of tyrocidine on Neupospora. (1966) (16)
- N-terminal chimeric constructs improve the expression of sarcoplasmic reticulum Ca(2+)-ATPase in yeast. (1999) (16)
- Isolation of a spontaneous CHO amino acid transport mutant by a combination of tritium suicide and replica plating (1982) (15)
- Net potassium transport in Neurospora: properties of a transport mutant. (1970) (15)
- Stimulation by serum of the Na+/H+ antiporter in quiescent pig kidney epithelial (LLC‐PK1) cells and role of the antiporter in the reinitiation of DNA synthesis (1987) (15)
- Coordination of K+ Transporters in Neurospora: TRK1 Is Scarce and Constitutive, while HAK1 Is Abundant and Highly Regulated (2013) (15)
- Biosynthesis of the plasma membrane H+-ATPase of Neurospora crassa. (1988) (14)
- Stalk Segment 5 of the Yeast Plasma Membrane H+-ATPase (2001) (14)
- Molecular cloning of NHE3 from LLC-PK1 cells and localization in pig kidney. (1999) (14)
- Molecular biology of renal Na(+)-H+ exchangers. (1991) (14)
- Primary structure of the plasma membrane H+-ATPase from the halotolerant alga Dunaliella bioculata (1995) (14)
- Role of transmembrane segment M8 in the biogenesis and function of yeast plasma-membrane H(+)-ATPase. (2007) (13)
- Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies (2018) (13)
- Stalk Segment 4 of the Yeast Plasma Membrane H+-ATPase (2000) (13)
- Effects of C-terminal Truncations on Trafficking of the Yeast Plasma Membrane H+-ATPase* (2006) (13)
- LLC-PK1 mutant with increased Na+-H+ exchange and decreased sensitivity to amiloride. (1988) (12)
- Properties of two mouse lymphocyte cell lines genetically defective in amino acid transport. (1979) (12)
- THE FUNCTION OF AN ALTERNATIVE TERMINAL OXIDASE IN NEUROSPORA (1978) (12)
- Stalk Segment 5 of the Yeast Plasma Membrane H+-ATPase (2002) (11)
- Isolation and characterization of a Na-H antiporter-deficient mutant of LLC-PK1 cells. (1986) (11)
- Cysteine 532 and cysteine 545 are the N-ethylmaleimide-reactive residues of the Neurospora plasma membrane H+-ATPase. (1989) (10)
- Energy Coupling in the Plasma Membrane of Neurospora: ATP-Dependent Proton Transport and Proton-Dependent Sugar Cotransport (1975) (10)
- The plasma membrane H+-ATPase of Neurospora crassa. Properties of two reactive sulfhydryl groups. (1988) (9)
- Whole cells for the study of transport linked to membrane potential: Neurospora crassa. (1979) (8)
- A structural change in the Neurospora plasma membrane [H+]ATPase induced by N-ethylmaleimide. (1990) (7)
- Mechanism and role of furosemide-sensitive K+ transport in L cells: A genetic approach (2005) (7)
- Proposed Changes for NIH's Center for Scientific Review (1999) (6)
- 3 – The Nucleotide-binding Site of the Plasma-membrane H+-ATPase of Neurospora crassa: A Comparison with other P-type ATPases (1989) (6)
- BIOCHEMICAL CHARACTERIZATION OF THE ELECTROGENIC PROTON PUMP OF THE NEUROSPORA PLASMA MEMBRANE1 (1978) (5)
- Heterologous expression of sarcoplasmic reticulum Ca2+-ATPase (1996) (5)
- Isolation and characterization of a glycine transport mutant in an established mammalian cell line, CHO(PEOT/1) (1987) (5)
- Permeability measurements on mitochondria from wild-type and poky strains of Neurospora crassa (1976) (4)
- Effects of Mg 2 + Ions on the Plasma Membrane [ H + ]-ATPase of Neurospora crassa (2001) (4)
- LLC-PK sub 1 mutant with increased Na sup + -H sup + exchange and decreased sensitivity to amiloride (1988) (3)
- Pharmacologically different Na / H antiporters on the apical and basolateral surfaces of cultured porcine kidney cells ( LLC-PK 1 ) ( ethylisopropylamiloride / transport activties / differentiation ) (3)
- Biochemical Characterization of the Fungal Plasma Membrane ATPase, An Electrogenic Proton Pump (1982) (3)
- Functional role of aspartyl and glutamyl residues in the membrane segments of the yeast PMA1 ATPase: Interaction with DCCD (2008) (3)
- Potassium Transport in Neurospora Evidence for a multisite carrier at high pH (2003) (3)
- Coordinated changes in potassium fluxes as early events in the differentiation of the human promyelocyte line HL-60. (1985) (3)
- Genes and Membranes (1978) (2)
- Genetic Determination of Membrane Transport (1978) (2)
- Yeast plasma-membrane H+-ATPase: The role of cysteine residues (2008) (2)
- Structural features of the yeast plasma-membrane H(+)-ATPase. (1994) (2)
- Epitope‐Tagged Constructs of the Yeast Plasma‐Membrane H+‐ATPase (2000) (2)
- Yeast Plasma‐Membrane H+‐ATPase: Model System for Studies of Structure, Function, Biogenesis, and Regulation (2005) (2)
- Molecular characterization of the plasma membrane proton translocating atpase of neurospora crassa (1986) (2)
- Genes and membranes : transport proteins and receptors (1985) (2)
- Stalk Segment 5 of the Yeast Plasma Membrane H 1-ATPase MUTATIONAL EVIDENCE FOR A ROLE IN GLUCOSE REGULATION * (2001) (2)
- Functional role of positively charged amino acid residues in the transmembrane segments of the yeast PMA1 ATPase (2008) (2)
- Yeast plasma-membrane H+-ATPase: Role of cys-409 in interaction of the enzyme with NEM and FITC (2008) (1)
- Use of a Fluorescent Maleimide to Probe Structure‐Function Relationships in Stalk Segments 4 and 5 of the Yeast Plasma‐Membrane H+‐ATPase (2003) (1)
- Quabain-resistant mutants of mouse and human lymphocytes. Abstr. (1975) (1)
- P-Type Pumps: Plasma-Membrane H + Pumps (2013) (1)
- Plasma‐Membrane H+‐ATPase From Yeast (2008) (1)
- GENETIC CONTROL OF CELLULAR TRANSPORT (1981) (1)
- ADVISORY COMMITTEE Of the Connecticut Bioscience Innovations Fund Minutes - Regular Meeting (2014) (0)
- Energy-linked potassium uptake by mitochondria from wild-type and poky strains of Neurospora crassa (1977) (0)
- Structure-function relationships in transmembrane segments 4, 5, and 6 of the yeast plasma-membrane H(+)-ATPase. (1998) (0)
- Highly Regulated Constitutive, while HAK1 Is Abundant and Neurospora: TRK1 Is Scarce and Transporters in + Coordination of K (2014) (0)
- P-Type Pumps: Plasma-Membrane H+ Pump (2004) (0)
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