A. Cecile J.W. Janssens
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Dutch epidemiologist
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A. Cecile J.W. Janssens's Degrees
- PhD Epidemiology Erasmus University Rotterdam
- Masters Epidemiology Erasmus University Rotterdam
- Bachelors Biology Utrecht University
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Why Is A. Cecile J.W. Janssens Influential?
(Suggest an Edit or Addition)According to Wikipedia, Anna Caecilia Josephina Wilhelmina Janssens was a Dutch epidemiologist and research professor of translational epidemiology at the Rollins School of Public Health of Emory University in Atlanta, Georgia, United States. Much of her research focused on polygenic score-based genetic risk prediction for complex diseases like diabetes and cardiovascular disease, of which she was critical. She also criticized what she considered an excessive focus on the role of genetics in attempts to prevent and treat human diseases.
A. Cecile J.W. Janssens's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids (2010) (3485)
- Genome-wide analysis of genetic loci associated with Alzheimer disease. (2010) (1177)
- Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts (2009) (909)
- Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE‐AF Consortium (2013) (561)
- Meta-analyses of genetic studies on major depressive disorder (2008) (445)
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure (2011) (424)
- Interpreting incremental value of markers added to risk prediction models. (2012) (408)
- Meta-analysis of genome-wide association studies for personality (2012) (369)
- Genome-based prediction of common diseases: advances and prospects. (2008) (319)
- Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies (2008) (292)
- Genome-wide association scan for five major dimensions of personality (2010) (288)
- Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners (2003) (288)
- CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease (2006) (277)
- A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. (2008) (276)
- Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. (2008) (253)
- Eye color and the prediction of complex phenotypes from genotypes (2009) (245)
- PredictABEL: an R package for the assessment of risk prediction models (2011) (240)
- Predictive testing for complex diseases using multiple genes: Fact or fiction? (2006) (232)
- The Scientific Foundation for Personal Genomics: Recommendations from a National Institutes of Health–Centers for Disease Control and Prevention Multidisciplinary Workshop (2009) (196)
- Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations (2012) (181)
- Improving reporting standards for polygenic scores in risk prediction studies (2020) (175)
- Anxiety and depression after prostate cancer diagnosis and treatment: 5-year follow-up (2006) (174)
- A nxiety and depression influence the relation between disability status and quality of life in multiple sclerosis (2003) (168)
- Self reported stressful life events and exacerbations in multiple sclerosis:prospective study (2003) (168)
- Genetic risk profiles for depression and anxiety in adult and elderly cohorts (2010) (163)
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways (2012) (150)
- Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways (2011) (149)
- The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases (2007) (146)
- Genome-Wide Association Studies, Field Synopses, and the Development of the Knowledge Base on Genetic Variation and Human Diseases (2009) (144)
- A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila (2011) (141)
- B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF Consortium of community-based cohort studies. (2014) (141)
- Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM (2011) (127)
- Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors (2013) (126)
- Predicting human height by Victorian and genomic methods (2009) (120)
- Survival in Elderly Persons with Down Syndrome (2008) (113)
- Family history and the natural history of colorectal cancer: systematic review (2015) (112)
- The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data (2011) (111)
- Prediction of anxiety and distress following diagnosis of multiple sclerosis: a two-year longitudinal study (2006) (102)
- Reflection on modern methods: Revisiting the area under the ROC Curve. (2020) (101)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (101)
- Using family history information to promote healthy lifestyles and prevent diseases; a discussion of the evidence (2010) (98)
- Shared genetic factors in migraine and depression (2010) (94)
- Prenatal exposure to the 1944-45 Dutch 'hunger winter' and addiction later in life. (2008) (90)
- A tiered-layered-staged model for informed consent in personal genome testing (2012) (90)
- Late-onset Pompe disease primarily affects quality of life in physical health domains (2004) (89)
- Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium. (2013) (89)
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts (2011) (89)
- Personal utility in genomic testing: is there such a thing? (2014) (89)
- Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis (2009) (88)
- Revisiting the clinical validity of multiplex genetic testing in complex diseases. (2004) (87)
- Genome-based prediction of common diseases: methodological considerations for future research (2009) (87)
- Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome (2012) (78)
- Evaluation of risk prediction updates from commercial genome-wide scans (2009) (74)
- Predicting Polygenic Obesity Using Genetic Information. (2017) (70)
- Impact of Communicating Familial Risk of Diabetes on Illness Perceptions and Self-Reported Behavioral Outcomes (2009) (70)
- Personal genome testing: Test characteristics to clarify the discourse on ethical, legal and societal issues (2011) (68)
- Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study (2010) (67)
- Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities (2011) (66)
- Perception of prognostic risk in patients with multiple sclerosis: the relationship with anxiety, depression, and disease-related distress. (2004) (65)
- Improvement of risk prediction by genomic profiling: reclassification measures versus the area under the receiver operating characteristic curve. (2010) (65)
- Variations in predicted risks in personal genome testing for common complex diseases (2013) (64)
- Validity of polygenic risk scores: are we measuring what we think we are? (2019) (61)
- Fatigue: an important feature of late-onset Pompe disease (2007) (59)
- Value of genetic profiling for the prediction of coronary heart disease. (2009) (56)
- Early age at menopause is associated with increased risk of dementia and mortality in women with Down syndrome. (2010) (54)
- 'It might happen or it might not': how patients with multiple sclerosis explain their perception of prognostic risk. (2004) (54)
- Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies (2008) (52)
- How can polygenic inheritance be used in population screening for common diseases? (2013) (51)
- Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration (2011) (50)
- An epidemiological perspective on the future of direct-to-consumer personal genome testing (2010) (48)
- Assessment of pharmacogenetic tests: presenting measures of clinical validity and potential population impact in association studies (2016) (48)
- A systematic review and critical assessment of 11 discordant meta-analyses on reduced-function CYP2C19 genotype and risk of adverse clinical outcomes in clopidogrel users (2014) (48)
- The Prediction of Radiotherapy Toxicity Using Single Nucleotide Polymorphism-Based Models: A Step Toward Prevention. (2015) (48)
- A New Logistic Regression Approach for the Evaluation of Diagnostic Test Results (2005) (47)
- Does Genetic Testing Really Improve the Prediction of Future Type 2 Diabetes? (2006) (44)
- Useless Until Proven Effective: The Clinical Utility of Preemptive Pharmacogenetic Testing (2014) (43)
- Value of EUS in Determining Curative Resectability in Reference to CT and FDG-PET: The Optimal Sequence in Preoperative Staging of Esophageal Cancer? (2011) (43)
- The role of disability and depression in cognitive functioning within 2 years after multiple sclerosis diagnosis (2008) (40)
- A study of the SORL1 gene in Alzheimer's disease and cognitive function. (2009) (38)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. (2011) (37)
- Novel citation-based search method for scientific literature: application to meta-analyses (2015) (37)
- The EGAPP initiative: lessons learned (2013) (37)
- Genome-Based Prediction of Breast Cancer Risk in the General Population: A Modeling Study Based on Meta-Analyses of Genetic Associations (2011) (36)
- Comparison of participant information and informed consent forms of five European studies in genetic isolated populations (2010) (35)
- Pregnancy in multiple sclerosis: clinical and self-report scales (2011) (35)
- Use of genomic profiling to assess risk for cardiovascular disease and identify individualized prevention strategies—A targeted evidence-based review (2010) (34)
- Clinical implications of old and new genes for open-angle glaucoma. (2011) (33)
- Genetic risk profiling for prediction of type 2 diabetes (2011) (33)
- Menopause impacts the relation of plasma adiponectin levels with the metabolic syndrome (2010) (33)
- Novel citation-based search method for scientific literature: a validation study (2019) (33)
- Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. (2009) (32)
- Expectations of wheelchair‐dependency in recently diagnosed patients with multiple sclerosis and their partners (2003) (32)
- Informed Consent in Direct‐To‐Consumer Personal Genome Testing: The Outline of a Model between Specific and Generic Consent (2014) (31)
- Recommendations from the EGAPP Working Group: does PCA3 testing for the diagnosis and management of prostate cancer improve patient health outcomes? (2013) (31)
- A Methodological Perspective on Genetic Risk Prediction Studies in Type 2 Diabetes: Recommendations for Future Research (2011) (31)
- Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement (2011) (30)
- Cost-Effectiveness of Risk-Stratified Colorectal Cancer Screening Based on Polygenic Risk: Current Status and Future Potential (2019) (30)
- A critical evaluation of the algorithm behind the Relative Citation Ratio (RCR) (2017) (30)
- Callosal lesion predicts future attacks after clinically isolated syndrome (2009) (29)
- Assessment of improved prediction beyond traditional risk factors: when does a difference make a difference? (2010) (29)
- Genetic Scoring Analysis: a way forward in Genome Wide Association Studies? (2009) (28)
- Patients with Barrett's esophagus perceive their risk of developing esophageal adenocarcinoma as low. (2007) (28)
- Accuracy of self-reported family history is strongly influenced by the accuracy of self-reported personal health status of relatives. (2012) (26)
- Predictive value of multiple genetic testing for age-related macular degeneration. (2007) (25)
- A Genome-Wide Screen for Depression in Two Independent Dutch Populations (2010) (24)
- Cost Effectiveness of Age-Specific Screening Intervals for People With Family Histories of Colorectal Cancer. (2018) (23)
- Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions (2012) (23)
- Ethnic differences and parental beliefs are important for overweight prevention and management in children: a cross-sectional study in the Netherlands (2012) (23)
- Genetic architecture of open angle glaucoma and related determinants (2010) (23)
- A genome-wide linkage study of individuals with high scores on NEO personality traits (2012) (23)
- Patients with multiple sclerosis prefer early diagnosis (2004) (22)
- Heritability of dietary food intake patterns (2012) (22)
- Genetic architecture of circulating lipid levels (2011) (21)
- Personalizing Breast Cancer Screening Based on Polygenic Risk and Family History (2020) (20)
- Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives. (2010) (19)
- Perspectives on the Use of Multiple Sclerosis Risk Genes for Prediction (2011) (19)
- Evaluation of Polygenic Risk Models Using Multiple Performance Measures: A Critical Assessment of Discordant Results (2018) (18)
- The sense and nonsense of direct-to-consumer genetic testing for cardiovascular disease (2011) (18)
- Is the time right for translation research in genomics? (2008) (18)
- Role of shared genetic and environmental factors in symptoms of depression and body composition (2009) (18)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (17)
- HFE gene mutations increase the risk of coronary heart disease in women (2010) (17)
- Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability (2011) (16)
- No association between the angiotensin-converting enzyme gene and major depression: a case-control study and meta-analysis. (2006) (16)
- IGF-1 CA repeat variant and breast cancer risk in postmenopausal women. (2007) (15)
- Genetic Factors Influence the Clustering of Depression among Individuals with Lower Socioeconomic Status (2009) (15)
- Towards predictive genetic testing of complex diseases (2006) (14)
- Designing babies through gene editing: science or science fiction? (2016) (14)
- Critical examination of current response shift methods and proposal for advancing new methods (2021) (14)
- The hidden harm behind the return of results from personal genome services: a need for rigorous and responsible evaluation (2014) (14)
- Apolipoprotein E gene is related to mortality only in normal weight individuals: The Rotterdam study (2007) (14)
- An empirical comparison of meta-analyses of published gene-disease associations versus consortium analyses (2009) (13)
- An Electrocardiogram-Based Risk Equation for Incident Cardiovascular Disease From the National Health and Nutrition Examination Survey. (2016) (13)
- Constructing Hypothetical Risk Data from the Area under the ROC Curve: Modelling Distributions of Polygenic Risk (2016) (12)
- Estimating the predictive ability of genetic risk models in simulated data based on published results from genome-wide association studies (2014) (11)
- Strengthening the reporting of Genetic Risk Prediction Studies: the GRIPS statement. (2011) (10)
- Discriminative accuracy of genomic profiling comparing multiplicative and additive risk models (2011) (10)
- Proprietary Algorithms for Polygenic Risk: Protecting Scientific Innovation or Hiding the Lack of It? (2019) (10)
- Small improvement in the area under the receiver operating characteristic curve indicated small changes in predicted risks. (2016) (10)
- Prediction impact curve is a new measure integrating intervention effects in the evaluation of risk models. (2016) (9)
- Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile. (2006) (9)
- Scientific reporting is suboptimal for aspects that characterize genetic risk prediction studies: a review of published articles based on the Genetic RIsk Prediction Studies statement. (2014) (9)
- Strengthening the reporting of Genetic RIsk Prediction Studies: the GRIPS Statement. (2011) (9)
- How Attitudes Research Contributes to Overoptimistic Expectations of Personal Genome Testing (2009) (9)
- Predictive ability of direct-to-consumer pharmacogenetic testing: when is lack of evidence really lack of evidence? (2013) (9)
- Carriage of reduced-function CYP2C19 allele among patients treated with clopidogrel. (2011) (8)
- Recommendations from the EGAPP Working Group: does the use of Oncotype DX tumor gene expression profiling to guide treatment decisions improve outcomes in patients with breast cancer? (2015) (8)
- Risk Prediction Models: A Framework for Assessment (2011) (8)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (7)
- External validation is only needed when prediction models are worth it (Letter commenting on: J Clin Epidemiol. 2015;68:25-34). (2016) (7)
- Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement (2011) (6)
- Analytical and simulation methods for estimating the potential predictive ability of genetic profiling: a comparison of methods and results (2012) (6)
- The ROC plot: the picture that could be worth a 1000 words. (2020) (6)
- How the Intended Use of Polygenic Risk Scores Guides the Design and Evaluation of Prediction Studies (2019) (6)
- Pencina et al. respond to "The incremental value of new markers" and "Clinically relevant measures? A note of caution". (2012) (5)
- NFL Injuries Before and After the 2011 Collective Bargaining Agreement (CBA). (2018) (5)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (5)
- Divorce and unemployment in multiple sclerosis: recalculation of the data of Morales-Gonzáles J M, Benito-Leon J, Rivera-Navarro J and Mitchell A J. (2004) (5)
- Health-Related Quality of Life in Patients with Musculoskeletal Complaints in a General Acupuncture Practice: An Observational Study (2010) (5)
- Quality criteria for health checks: development of a European consensus agreement. (2014) (5)
- Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration (2011) (4)
- Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration. (2011) (4)
- Why Realistic Test Scenarios in Translational Genomics Research Remain Hypothetical (2009) (4)
- Uninformed consent in nutrigenomic research (2017) (4)
- Ethnicity, educational level and attitudes contribute to parental intentions about genetic testing for child obesity (2013) (4)
- Meta-analysis of genome-wide association results in > 10.000 individuals for the big five personality traits (2009) (4)
- Returning pharmacogenetic secondary findings from genome sequencing: let’s not put the cart before the horse (2015) (4)
- Raw data: access to inaccuracy. (2014) (3)
- Finding Wealth in Waste: Irreplicability Re‐Examined (2018) (3)
- Societal implications of expanded universal carrier screening: a scoping review (2022) (3)
- Naming and framing in genomic testing. (2014) (3)
- Adaptation is favorable for most patients with multiple sclerosis. (2004) (3)
- Predictive or not predictive: understanding the mixed messages from the patient's DNA sequence. (2015) (2)
- [Biobanks and the return of results to donors]. (2014) (2)
- Reply to Stephan et al. (2008) (2)
- A more intuitive interpretation of the area under the ROC curve (2017) (1)
- Prediction Research An introduction (2018) (1)
- Impact of presymptomatic genetic testing for hereditary ataxia and neuromuscular disorders: where is the evidence? (2005) (1)
- Erratum to: Novel citation-based search method for scientific literature: application to meta-analyses (2015) (1)
- The Value of Genetic Variation in the Prediction of Obesity (2016) (1)
- Lowering the P Value Threshold. (2018) (1)
- Do we measure or compute polygenic risk scores? Why language matters (2020) (1)
- CHOLESTERYL ESTER TRANSFER PROTEIN GENE AND CORONARY HEART DISEASE MORTALITY: THE ROTTERDAM STUDY (2007) (1)
- When Does a Difference Make a Difference? (2010) (1)
- Stress and exacerbations in multiple sclerosis (2004) (1)
- Assessing predictive performance beyond the Framingham risk score. (2010) (1)
- Direct-to-Consumer Genetic Testing (2019) (1)
- The data and analysis underlying NIH’s decision to cap research support lacked rigor and transparency: a commentary (2017) (1)
- Risk Analysis of Prostate Cancer in PRACTICAL Consortium—Letter (2016) (1)
- It is time to get real when trying to predict educational performance (2020) (1)
- ROC curves for clinical prediction models Part 4: Selection of the risk threshold: once chosen, always the same? (2020) (1)
- The Million Women Study: what's in the name? (2017) (0)
- Genome-wide association analysis of coffee drinking suggests association with CYP1A1CYP1A2 and NRCAM (2012) (0)
- Supplementary Material (nature09270-s1) (2012) (0)
- Derivation and Validation of a Risk Model for Emergency Department Palliative Care Needs Assessment Using the Screen for Palliative and End-of-Life Care Needs in the Emergency Department (SPEED) (TH347-A) (2015) (0)
- Prediction of Age-related Macular Degeneration based on Genotype and Phenotype in the Population-based Rotterdam Study (2012) (0)
- OP-JNCI200131 434..442 (2021) (0)
- 'Whole genome sequencing' NIEuWE moGElIJKHEDEN voo R DE GEzo NDHEIDSzo RG? (2010) (0)
- the Environment Reaching the Limits of Genome-wide Significance in Alzheimer Disease : Back to (2010) (0)
- 4CPS-108 Patient and physicians’s satisfaction with clinical pharmacy services on a haematology ward in a large tertiary care hospital (2023) (0)
- Derivation and validation of a risk model for emergency department palliative care needs assessment using the Screen for Palliative and End-of-Life Care Needs in the Emergency Department (SPEED). (2014) (0)
- Five genetic variants associated with prostate cancer. (2008) (0)
- Two Authors Reply (2011) (0)
- Communication skills training in advance care planning: a survey among medical students at the University of Antwerp (2022) (0)
- Rethinking and Co-Design of Beloved Board Games for People With Mild Cognitive Impairment and Their Care Partners (2020) (0)
- Decision letter: Can education be personalised using pupils’ genetic data? (2019) (0)
- Response to letter Dr Gail. (2017) (0)
- [Whole genome sequencing--new opportunities for health care practice?]. (2010) (0)
- Reply to “Disease risks derived from genetic variants need clinical context” (2010) (0)
- Gezondheidsraad. Next generation sequencing in diagnostiek (2015) (0)
- Defining Evidence for Precision Medicine: A Patient Is More Than a Set of Covariates. (2019) (0)
- Mitochondrial DNA haplogroups and age-related maculopathy. Commentary (2007) (0)
- University of Groningen Value of EUS in Determining Curative Resectability in Reference to CT and FDG-PET (2011) (0)
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