Chaitan Khosla
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Indian American chemical engineer
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Chemistry
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#1370
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Chemical Engineering
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Chemistry
Chaitan Khosla's Degrees
- PhD Chemical Engineering Stanford University
- Masters Chemical Engineering Stanford University
Why Is Chaitan Khosla Influential?
(Suggest an Edit or Addition)According to Wikipedia, Chaitan Khosla is an Indian biochemist who is the Wells H. Rauser and Harold M. Petiprin Professor of Chemical Engineering and Chemistry at Stanford University. He earned his B.Tech. in chemical engineering from Indian Institute of Technology Bombay in 1985 and his Ph.D. from the California Institute of Technology in 1990 with Jay Bailey working on the expression of the Vitreoscilla Hemoglobin gene. He did his postdoctoral work at the John Innes Centre with David Hopwood. He has been a professor at Stanford since 1992 and was the chair of the program. His research is focused on two realms, the first are to build a molecular understanding of polyketide synthases and the second is focused on the biochemistry of celiac disease particularly involving tissue transglutaminase. His group play a large role in identifying the role of the α2-gliadin fragment in immune responses.
Chaitan Khosla's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structural Basis for Gluten Intolerance in Celiac Sprue (2002) (1487)
- A new enzyme superfamily - the phosphopantetheinyl transferases. (1996) (736)
- Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli (2001) (642)
- Harnessing the biosynthetic code: combinations, permutations, and mutations. (1998) (558)
- Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease (2004) (421)
- Transglutaminase 2 Undergoes a Large Conformational Change upon Activation (2007) (407)
- Overproduction of free fatty acids in E. coli: implications for biodiesel production. (2008) (366)
- Cloning and heterologous expression of the epothilone gene cluster. (2000) (363)
- Intestinal digestive resistance of immunodominant gliadin peptides. (2002) (356)
- Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease (2017) (321)
- Tolerance and specificity of polyketide synthases. (1999) (304)
- Dissecting and exploiting intermodular communication in polyketide synthases. (1999) (298)
- Engineered biosynthesis of novel polyketides. (1993) (270)
- Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. (2005) (267)
- Biosynthesis of Polyketides in Heterologous Hosts (2001) (262)
- Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. (2013) (254)
- Structure and mechanism of the 6-deoxyerythronolide B synthase. (2007) (246)
- The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase (2006) (236)
- Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits (1995) (235)
- Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. (1997) (226)
- Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli (1988) (225)
- Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. (2007) (220)
- Engineered biosynthesis of a complete macrolactone in a heterologous host. (1994) (217)
- Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. (2004) (217)
- Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. (2010) (213)
- Transglutaminase 2 inhibitors and their therapeutic role in disease states. (2007) (205)
- Metabolic engineering for drug discovery and development (2003) (200)
- Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury (2008) (191)
- Future therapeutic options for celiac disease (2005) (188)
- Role of linkers in communication between protein modules. (2000) (180)
- Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel (2001) (179)
- Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy (2007) (177)
- Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. (2005) (170)
- Harnessing the Biosynthetic Potential of Modular Polyketide Synthases. (1997) (170)
- Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease (2013) (169)
- Redox Regulation of Transglutaminase 2 Activity* (2010) (168)
- Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster (2001) (157)
- Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. (2000) (156)
- Antigen Presentation to Celiac Lesion-Derived T Cells of a 33-Mer Gliadin Peptide Naturally Formed by Gastrointestinal Digestion1 (2004) (154)
- An antibiotic factory caught in action (2004) (154)
- Biosynthesis of aromatic polyketides in bacteria. (2009) (153)
- Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways (2013) (152)
- Toward the Assessment of Food Toxicity for Celiac Patients: Characterization of Monoclonal Antibodies to a Main Immunogenic Gluten Peptide (2008) (146)
- Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase (1995) (146)
- Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification (2016) (145)
- Rational design of combination enzyme therapy for celiac sprue. (2006) (145)
- Evolution of polyketide synthases in bacteria (2008) (144)
- Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. (2007) (142)
- In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli (2011) (141)
- Prolyl Endopeptidase-Mediated Destruction of T Cell Epitopes in Whole Gluten: Chemical and Immunological Characterization (2005) (139)
- High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue. (2002) (135)
- Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase. (1994) (131)
- Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. (2003) (130)
- HEx: A heterologous expression platform for the discovery of fungal natural products (2018) (130)
- Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase. (1999) (129)
- Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. (2005) (127)
- Genetic engineering of Escherichia coli for biofuel production. (2010) (124)
- Combinatorial biosynthesis of polyketides--a perspective. (2012) (123)
- Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. (2000) (118)
- Novel therapies for coeliac disease (2011) (118)
- Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. (2002) (116)
- Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. (2001) (116)
- Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. (2001) (115)
- Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. (2005) (112)
- Expression of Intracellular Hemoglobin Improves Protein Synthesis in Oxygen-Limited Escherichia coli (1990) (110)
- Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. (2006) (110)
- Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2) (1995) (108)
- Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules. (2001) (107)
- Biosynthesis of Yersiniabactin, a Complex Polyketide-Nonribosomal Peptide, Using Escherichia coli as a Heterologous Host (2003) (107)
- Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. (2002) (105)
- Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems (2014) (104)
- Activation of Extracellular Transglutaminase 2 by Thioredoxin* (2011) (104)
- Solution structure and proposed domain–domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase (2007) (103)
- Evolution and Diversity of Assembly-Line Polyketide Synthases (2019) (102)
- Polyketide chain length control by chain length factor. (2003) (100)
- Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. (2007) (98)
- Structure and mechanism of assembly line polyketide synthases. (2016) (97)
- A Food-Grade Enzyme Preparation with Modest Gluten Detoxification Properties (2009) (95)
- Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. (2003) (95)
- Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase (1994) (94)
- Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. (2006) (91)
- Generation of polyketide libraries via combinatorial biosynthesis. (1996) (91)
- Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas (2005) (91)
- Effect of Prolyl Endopeptidase on Digestive-Resistant Gliadin Peptides in Vivo (2004) (90)
- Characterization of the oxygen-dependent promoter of the Vitreoscilla hemoglobin gene in Escherichia coli (1989) (89)
- Structures and mechanisms of polyketide synthases. (2009) (89)
- Engineering the acyltransferase substrate specificity of assembly line polyketide synthases (2013) (88)
- Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation (2012) (88)
- IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease (2019) (87)
- Prolyl endopeptidases (2006) (87)
- Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases (1995) (86)
- Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. (2003) (86)
- Process and Metabolic Strategies for Improved Production of Escherichia coli-Derived 6-Deoxyerythronolide B (2002) (85)
- Protein engineering of improved prolyl endopeptidases for celiac sprue therapy. (2008) (83)
- Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli (2003) (83)
- Revisiting the modularity of modular polyketide synthases. (2009) (83)
- Novel aspects of quantitation of immunogenic wheat gluten peptides by liquid chromatography-mass spectrometry/mass spectrometry. (2010) (82)
- Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. (2002) (82)
- Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase (2010) (82)
- Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase. (1996) (82)
- Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases (1998) (82)
- Engineered intermodular and intramodular polyketide synthase fusions. (1997) (81)
- Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial (2020) (80)
- Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins (1993) (80)
- Combinatorial biosynthesis of 'unnatural' natural products: the polyketide example. (1995) (80)
- Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. (2007) (79)
- Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin. (2006) (79)
- Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities (1993) (78)
- A Non-Human Primate Model for Gluten Sensitivity (2008) (78)
- ENGINEERED BIOSYNTHESIS OF A TRIKETIDE LACTONE FROM AN INCOMPLETE MODULAR POLYKETIDE SYNTHASE (1994) (77)
- Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. (1999) (77)
- Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars (2017) (77)
- Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. (2005) (76)
- Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. (2006) (76)
- Modular enzymes : Biocatalysis: Synthesis methods that exploit enzymatic activities (2001) (76)
- Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively (1994) (75)
- Role of transglutaminase 2 in celiac disease pathogenesis (2012) (74)
- Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor. (1994) (73)
- Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. (2002) (73)
- The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. (2006) (73)
- Kinetic and Structural Analysis of a New Group of Acyl-CoA Carboxylases Found in Streptomyces coelicolor A3(2)* (2002) (72)
- Oral enzyme therapy for celiac sprue. (2012) (72)
- Understanding Substrate Specificity of Polyketide Synthase Modules by Generating Hybrid Multimodular Synthases* (2003) (71)
- The biochemical basis for stereochemical control in polyketide biosynthesis. (2009) (71)
- Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. (2011) (71)
- Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity. (2004) (71)
- Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. (2007) (70)
- GAIN OF FUNCTION MUTAGENESIS OF THE ERYTHROMYCIN POLYKETIDE SYNTHASE. 2. ENGINEERED BIOSYNTHESIS OF AN EIGHT-MEMBERED RING TETRAKETIDE LACTONE (1997) (70)
- Structure-based dissociation of a type I polyketide synthase module. (2007) (70)
- Effect of Barley Endoprotease EP-B2 on Gluten Digestion in the Intact Rat (2006) (68)
- ALCOHOL STEREOCHEMISTRY IN POLYKETIDE BACKBONES IS CONTROLLED BY THE BETA -KETOREDUCTASE DOMAINS OF MODULAR POLYKETIDE SYNTHASES (1998) (68)
- Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein (1992) (67)
- Cloning, Nucleotide Sequence, and Heterologous Expression of the Biosynthetic Gene Cluster for R1128, a Non-steroidal Estrogen Receptor Antagonist (2000) (67)
- Enhancement of Dietary Protein Digestion by Conjugated Bile Acids (2007) (67)
- The Vitreoscilla hemoglobin gene: Molecular cloning, nucleotide sequence and genetic expression in Escherichia coli (1988) (67)
- In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase. (2013) (65)
- Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. (2005) (65)
- Activation and Inhibition of Transglutaminase 2 in Mice (2012) (65)
- Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. (2010) (64)
- Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase (1996) (63)
- Evidence for partial export of Vitreoscilla hemoglobin into the periplasmic space in Escherichia coli. Implications for protein function. (1989) (62)
- Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. (2011) (62)
- Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. (2003) (61)
- Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases (2004) (60)
- A functional chimeric modular polyketide synthase generated via domain replacement. (1996) (60)
- Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase. (2014) (60)
- Parallels between Pathogens and Gluten Peptides in Celiac Sprue (2008) (60)
- Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. (2004) (60)
- Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases. (2010) (59)
- Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer. (2000) (59)
- The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates. (2001) (58)
- Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment. (2016) (56)
- PURIFICATION AND IN VITRO RECONSTITUTION OF THE ESSENTIAL PROTEIN COMPONENTS OF AN AROMATIC POLYKETIDE SYNTHASE (1998) (56)
- Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. (2012) (55)
- Building-block selectivity of polyketide synthases. (2003) (55)
- Building A "GenBank" of the Published Literature (2001) (55)
- Gain-of-Function Mutagenesis of a Modular Polyketide Synthase (1997) (55)
- Computational identification and analysis of orphan assembly-line polyketide synthases (2013) (54)
- Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. (2003) (54)
- Modular enzymes (2001) (54)
- Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase. (2013) (53)
- Precursor-directed biosynthesis of epothilone in Escherichia coli. (2004) (53)
- Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. (2003) (52)
- Analysis of the Molecular Recognition Features of Individual Modules Derived from the Erythromycin Polyketide Synthase (2000) (52)
- Regulation of the activities of the mammalian transglutaminase family of enzymes (2012) (52)
- Use of transmission electron microscopy to identify nanocrystals of challenging protein targets (2014) (52)
- Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. (2002) (51)
- Natural product biosynthesis: a new interface between enzymology and medicine. (2000) (51)
- Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides. (2002) (51)
- Therapeutic approaches for celiac disease. (2015) (50)
- Genes for polyketide secondary metabolic pathways in microorganisms and plants. (1992) (50)
- ENGINEERED BIOSYNTHESIS OF NOVEL POLYKETIDES : ANALYSIS OF TCMN FUNCTION IN TETRACENOMYCIN BIOSYNTHESIS (1995) (49)
- Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity (2022) (49)
- Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice. (2014) (48)
- Substrate specificity of the loading didomain of the erythromycin polyketide synthase. (2000) (48)
- Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases (2014) (48)
- Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. (2003) (47)
- Probing the interactions of an acyl carrier protein domain from the 6‐deoxyerythronolide B synthase (2011) (47)
- RATIONAL DESIGN AND ENGINEERED BIOSYNTHESIS OF A NOVEL 18-CARBON AROMATIC POLYKETIDE (1997) (47)
- Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor. (2012) (47)
- Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy. (2017) (47)
- Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase. (1994) (47)
- Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. (2007) (47)
- Evidence for Transcriptional Regulation of the Glucose‐6‐Phosphate Transporter by HIF‐1α: Targeting G6PT with Mumbaistatin Analogs in Hypoxic Mesenchymal Stromal Cells (2009) (47)
- Enhancement of dietary protein digestion by conjugated bile acids. (2007) (46)
- Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases* (2016) (46)
- Main Chain Hydrogen Bond Interactions in the Binding of Proline-rich Gluten Peptides to the Celiac Disease-associated HLA-DQ2 Molecule* (2005) (45)
- Engineered Biosynthesis of Novel Polyketides: Properties of the whiE Aromatase/Cyclase (1996) (45)
- KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 (2022) (45)
- Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. (2005) (45)
- Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates. (1996) (45)
- Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. (2001) (44)
- A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases (2016) (43)
- Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. (2008) (43)
- Strategies and Challenges in Metabolic Engineering a (1990) (43)
- Relaxed Specificity of the Oxytetracycline Polyketide Synthase for an Acetate Primer in the Absence of a Malonamyl Primer (1994) (43)
- Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2 (2014) (42)
- Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins. (2001) (42)
- Expression of Recombinant Proteins in Escherichia coli Using an Oxygen-Responsive Promoter (1990) (42)
- Latiglutenase Improves Symptoms in Seropositive Celiac Disease Patients While on a Gluten-Free Diet (2017) (42)
- Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. (2003) (42)
- Transepithelial Transport and Enzymatic Detoxification of Gluten in Gluten-Sensitive Rhesus Macaques (2008) (41)
- In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase. (2001) (41)
- Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase. (2016) (41)
- Tissue Transglutaminase-Mediated Formation and Cleavage of Histamine-Gliadin Complexes: Biological Effects and Implications for Celiac Disease1 (2005) (41)
- The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. (2004) (41)
- Enhancing the Atom Economy of Polyketide Biosynthetic Processes through Metabolic Engineering (2001) (40)
- Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase. (1998) (40)
- A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. (2003) (40)
- Bioassay-Guided Evolution of Glycosylated Macrolide Antibiotics in Escherichia coli (2007) (40)
- Interferon-γ Released by Gluten-Stimulated Celiac Disease-Specific Intestinal T Cells Enhances the Transepithelial Flux of Gluten Peptides (2009) (40)
- Erythromycin Biosynthesis: The β-Ketoreductase Domains Catalyze the Stereospecific Transfer of the 4-pro-S Hydride of NADPH (1998) (39)
- Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. (2004) (38)
- Utilization of Enzymatically Phosphopantetheinylated Acyl Carrier Proteins and Acetyl−Acyl Carrier Proteins by the Actinorhodin Polyketide Synthase† (1997) (37)
- Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase. (1997) (37)
- Engineered biosynthesis of aklanonic acid analogues. (2005) (36)
- Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents. (1996) (36)
- Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation. (2014) (36)
- Selective inhibition of extracellular thioredoxin by asymmetric disulfides. (2013) (36)
- Remarkably broad substrate specificity of a modular polyketide synthase in a cell-free system (1995) (35)
- Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition. (2003) (35)
- CYP3A4-Catalyzed Simvastatin Metabolism as a Non-Invasive Marker of Small Intestinal Health in Celiac Disease (2013) (35)
- Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase. (1999) (34)
- Structure-activity relationships within a family of selectively cytotoxic macrolide natural products. (2001) (34)
- Kinetic Analysis of the Actinorhodin Aromatic Polyketide Synthase* (1999) (34)
- The chemistry and biology of fatty acid, polyketide, and nonribosomal peptide biosynthesis (1997) (34)
- Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase. (2006) (33)
- Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. (2018) (33)
- Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. (1997) (33)
- Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase. (2001) (33)
- Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). (2006) (33)
- Chemistry and biology of macrolide antiparasitic agents. (2011) (32)
- PRIMER UNIT SPECIFICITY IN RIFAMYCIN BIOSYNTHESIS PRINCIPALLY RESIDES IN THE LATER STAGES OF THE BIOSYNTHETIC PATHWAY (1998) (32)
- Domain Analysis of the Molecular Recognition Features of Aromatic Polyketide Synthase Subunits* (1997) (32)
- In Living Color: Bacterial Pigments as an Untapped Resource in the Classroom and Beyond (2010) (31)
- Characterization of transglutaminase type II role in dendritic cell differentiation and function (2010) (31)
- Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. (2003) (31)
- Interferon-γ Activates Transglutaminase 2 via a Phosphatidylinositol-3-Kinase-Dependent Pathway: Implications for Celiac Sprue Therapy (2012) (31)
- Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board (2016) (30)
- Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. (2005) (30)
- Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine (2016) (29)
- Circular Dichroism and Nuclear Magnetic Resonance Spectroscopic Analysis of Immunogenic Gluten Peptides and Their Analogs* 210 (2002) (29)
- Visualization of Transepithelial Passage of the Immunogenic 33-Residue Peptide from α-2 Gliadin in Gluten-Sensitive Macaques (2010) (29)
- Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange (2014) (29)
- Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses. (2005) (29)
- Synthesis and Incorporation of an N-Acetylcysteamine Analogue of Methylmalonyl-CoA by a Modular Polyketide Synthase (1998) (29)
- Rational Design of Aromatic Polyketide Natural Products by Recombinant Assembly of Enzymatic Subunits. (1995) (29)
- Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange. (2013) (29)
- Precursor-directed biosynthesis of 12-ethyl erythromycin. (1998) (29)
- Efficient Synthesis of Aromatic Polyketides in Vitro by the Actinorhodin Polyketide Synthase (1996) (28)
- Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. (2001) (28)
- Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles. (2001) (27)
- Process development and metabolic engineering for the overproduction of natural and unnatural polyketides. (2001) (27)
- Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension. (2017) (27)
- Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. (1998) (27)
- The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of Synechococcus sp. PCC 7002. (2014) (26)
- Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. (2008) (26)
- Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. (2011) (25)
- Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase. (1999) (24)
- Endoplasmic reticulum–resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2 (2018) (24)
- Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. (2012) (24)
- Dihydroisoxazole analogs for labeling and visualization of catalytically active transglutaminase 2. (2011) (24)
- Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase (2014) (24)
- In Vitro Reconstitution of Metabolic Pathways: Insights into Nature’s Chemical Logic (2015) (24)
- Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases. (2013) (24)
- Prospects for Antibacterial Discovery and Development. (2021) (23)
- In vivo and in vitro analysis of the hedamycin polyketide synthase. (2009) (23)
- Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase. (1996) (23)
- Engineering of chimeric polyketide synthases using SYNZIP docking domains (2018) (23)
- A scaleable manufacturing process for pro‐EP‐B2, a cysteine protease from barley indicated for celiac sprue (2007) (22)
- Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis. (2010) (22)
- Precursor-Directed polyketide biosynthesis in Escherichia coli. (2003) (22)
- Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism. (2018) (22)
- Metabolic flux between unsaturated and saturated fatty acids is controlled by the FabA:FabB ratio in the fully reconstituted fatty acid biosynthetic pathway of Escherichia coli. (2013) (22)
- The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products. (2002) (22)
- Improved Precursor Directed Biosynthesis in E. coli via Directed Evolution (2010) (21)
- Substrates, inhibitors, and probes of mammalian transglutaminase 2. (2019) (21)
- A New Route to Designer Antibiotics (2005) (21)
- Dissecting the Chain Length Specificity in Bacterial Aromatic Polyketide Synthases using Chimeric Genes (2000) (21)
- Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on >70 kDa Polypeptides by Using Fourier‐Transform Mass Spectrometry (2006) (20)
- A Balancing Act for Taxol Precursor Pathways in E. coli (2010) (20)
- Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease. (2013) (20)
- The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. (2017) (20)
- Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase. (1996) (20)
- Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase. (1998) (20)
- A new oxygen-regulated promoter for the expression of proteins in Escherichia coli. (1989) (20)
- Tissue transgluaminase 2 expression in meningiomas (2008) (20)
- Directed Transfer of Large DNA Fragments betweenStreptomyces Species (2000) (20)
- 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2. (1996) (19)
- Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides. (2005) (19)
- Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host. (1995) (19)
- Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities (1999) (19)
- Manipulation and analysis of polyketide synthases. (2004) (19)
- Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. (2016) (18)
- Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin (2018) (18)
- Biosynthesis and structure-activity relationships of the lipid a family of glycolipids. (2017) (18)
- Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism (2020) (18)
- A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line. (2003) (18)
- Structure-based mutagenesis of the malonyl-CoA:acyl carrier protein transacylase from Streptomyces coelicolor. (2003) (17)
- Mapping the catalytic conformations of an assembly-line polyketide synthase module (2021) (17)
- Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis. (2016) (17)
- Engineered Biosynthesis of the Antiparasitic Agent Frenolicin B and Rationally Designed Analogs in a Heterologous Host (2011) (17)
- Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase. (2003) (17)
- SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical Samples (2021) (17)
- Antibiotic production from the ground up (2007) (17)
- New directions in metabolic engineering. (1998) (17)
- Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea. (2017) (16)
- Pharmacologic transglutaminase inhibition attenuates drug‐primed liver hypertrophy but not Mallory body formation (2006) (16)
- Favipiravir for Treatment of Outpatients With Asymptomatic or Uncomplicated Coronavirus Disease 2019: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial (2021) (16)
- Production of Ansamycin Polyketide Precursors in Escherichia coli (2006) (16)
- Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. (2004) (16)
- Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas (2011) (15)
- Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis. (2010) (15)
- Latiglutenase treatment for celiac disease: symptom and quality of life improvement for seropositive patients on a gluten‐free diet (2019) (15)
- Structure-activity relationships of semisynthetic mumbaistatin analogs. (2007) (15)
- Quo vadis, enzymology? (2015) (14)
- Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. (2011) (14)
- Synthesis and biological activity of novel pyranopyrones derived from engineered aromatic polyketides. (2007) (14)
- Precursor‐Directed Biosynthesis: Stereospecificity for Branched‐Chain Diketides of the β‐Ketoacyl‐ACP Synthase Domain 2 of 6‐Deoxyerythronolide B Synthase (2003) (14)
- Recognition of Acyl Carrier Proteins by Ketoreductases in Assembly Line Polyketide Synthases (2016) (13)
- Inhibition of Tubulogenesis and of Carcinogen‐mediated Signaling in Brain Endothelial Cells Highlight the Antiangiogenic Properties of a Mumbaistatin Analog (2010) (13)
- Noninflammatory gluten peptide analogs as biomarkers for celiac sprue. (2009) (13)
- Engineered biosynthesis of polyketides in heterologous hosts (2004) (13)
- Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. (2017) (13)
- Exploring the biosynthetic potential of bimodular aromatic polyketide synthases (2004) (13)
- Evolutionally guided enzyme design. (1996) (12)
- Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) Synthase (2020) (12)
- Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. (2017) (12)
- In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei (2011) (12)
- Dissecting the Evolutionary Relationship between 14-Membered and 16-Membered Macrolides (1998) (12)
- A host-vector system for analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei. (1999) (12)
- Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. (2005) (12)
- Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis. (2005) (11)
- Natural product inhibitors of glucose-6-phosphate translocase (2012) (11)
- Rationale for Using Social Media to Collect Patient-Reported Outcomes in Patients with Celiac Disease (2014) (10)
- Harnessing the Biosynthetic Potential of Modular Polyketide Synthases (1998) (10)
- A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease (2017) (10)
- An unprecedented dual antagonist and agonist of human Transglutaminase 2. (2015) (10)
- Specificity and versatility in erythromycin biosynthesis (1997) (10)
- Engineering site-selective incorporation of fluorine into polyketides (2022) (10)
- Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. (2017) (9)
- Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli (2017) (9)
- Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3 (2014) (9)
- Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Synthases (2005) (9)
- Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. (1997) (9)
- Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease. (2012) (9)
- Precursor‐Directed Biosynthesis of Erythromycin Analogues by an Engineered Polyketide Synthase (1997) (8)
- Solution Structure and Conformational Flexibility of a Polyketide Synthase Module (2021) (8)
- Biochemistry: Fit for an enzyme (2008) (8)
- Combinatorial chemistry and biology: an opportunity for engineers. (1996) (8)
- Analysis and refactoring of the A-74528 biosynthetic pathway. (2013) (7)
- Celiac Disease: Lessons for and from Chemical Biology. (2017) (7)
- Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. (2019) (7)
- Structure, Function, and Engineering of Bacterial Aromatic Polyketide Synthases (1999) (6)
- An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease (2021) (6)
- Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. (2018) (6)
- GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification (2021) (5)
- A genome-wide analysis of targets of macrolide antibiotics in mammalian cells (2020) (5)
- Biochemistry—engineering interface in biochemical engineering (2002) (5)
- Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. (2020) (5)
- Discovery and Mechanism of Type III Secretion System Inhibitors (2013) (5)
- Chemistry. A new route to designer antibiotics. (2005) (5)
- Substrate tolerance of module 6 of the epothilone synthetase. (2007) (5)
- In vivo visualization and molecular targeting of the cardiac conduction system (2022) (4)
- Antibiotic activity of polyketide products derived from combinatorial biosynthesis: Implications for directed evolution (1996) (4)
- Tunable Enzymatic Synthesis of the Immunomodulator Lipid IVA To Enable Structure-Activity Analysis. (2019) (4)
- Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2. (2006) (4)
- Trapping transient protein-protein interactions in polyketide biosynthesis. (2006) (4)
- Efficient Sampling of Protein Sequence Space for Multiple Mutants (1994) (4)
- Challenges and opportunities for engineering assembly-line polyketide biosynthesis in Escherichia coli (2019) (3)
- Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides (2008) (3)
- 1001 Extracellular Transglutaminase 2 Is Catalytically Inactive, But Is Transiently Activated Upon Tissue Injury in the Small Intestine (2008) (3)
- Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients with Celiac Disease Exposed to a Gluten Challenge. (2022) (3)
- S1263 Implications of Enzymatic Detoxification of Food Gluten in Coeliac Disease (2008) (3)
- Oral Latiglutenase Improves Chronic Symptoms in Seropositive Celiac Disease Patients (2017) (3)
- Engineering of Novel Polyketides (1996) (3)
- An Unusual "OR" Gate for Allosteric Regulation of Mammalian Transglutaminase 2 in the Extracellular Matrix. (2021) (3)
- Biological chemistry: Just add chlorine (2005) (3)
- Cholestyramine as a promising, strong anion exchange resin for direct capture of genetic biomarkers from raw pancreatic fluids. (2017) (3)
- Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells (2022) (2)
- In Vivo Measurement of Redox-Regulated TG2 Activity. (2019) (2)
- Combinatorial Biosynthesis: New Tools for the Medicinal Chemist (1998) (2)
- Engineering Escherichia coli for Biotransformation of Biomass into Fatty Acid Derived Fuels (2012) (2)
- , Permutations , and Mutations Harnessing the Biosynthetic Code : Combinations (2008) (2)
- Fragment antigen binding domains (Fabs) as tools to study assembly-line polyketide synthases (2021) (2)
- Intracellular TG2 Activity Increases Microtubule Stability but is not Sufficient to Prompt Neurite Growth (2017) (2)
- Engineering and Overproduction of Polyketide Natural Products (2008) (2)
- Biosynthesis of Aromatic Polyketides in Bacteria (2009) (2)
- Identification of polyketide biosynthetic gene clusters that harbor self-resistance target genes (2020) (2)
- Combinatorial Biosynthesis of “Unnatural” Natural Products: The Polyketide Example (1995) (2)
- Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase. (2020) (2)
- Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study (2022) (2)
- Malonyl-CoA:ACP Transacylase (2003) (2)
- Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase (2014) (2)
- Characterization of Natural Product Biosynthetic Pathways by In Vitro Reconstitution (2019) (1)
- The Stanford Institute for Chemical Biology. (2013) (1)
- Precursor‐Directed Biosynthesis of Polyketide and Nonribosomal Peptide Natural Products (2012) (1)
- Vitreoscilla hemoglobin: gene structure and regulation functions, and applications to aerobic bioprocesses (1990) (1)
- The Convergence of Chemistry & Human Biology (2014) (1)
- Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3 (2014) (1)
- Engineering site-selective incorporation of fluorine into natural product analogs (2021) (1)
- From Active Sites to Machines: A Challenge for Enzyme Chemists. (2018) (1)
- Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE) (2002) (1)
- - 1-Circular Dichroism and Nuclear Magnetic Resonance Spectroscopic Analysis of Immunogenic Gluten Peptides and their Analogs (2002) (1)
- A Mouse Model of Celiac Disease (2022) (1)
- Protein Engineering of Modular Polyketide Synthases (2011) (1)
- Generation of Polyketide Libraries via Combinatorial Biosynthesis (1997) (1)
- Structures and Mechanisms of Polyketide Synthases (2009) (1)
- A tribute to Professor Jay Bailey: A pioneer in biochemical engineering (2018) (1)
- Enzyme treatment of foodstuffs for celiac (2003) (1)
- IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease (2020) (1)
- Thematic Minireview Series on Antibacterial Natural Products: New Tricks for Old Dogs* (2010) (1)
- Engineering of molecular and cellular biocatalysts: selected contributions by James E. Bailey. (2002) (1)
- Crystal structure of HLA-DQ2 complexed with deamidated gliadin peptide (2004) (1)
- Shared within-host SARS-CoV-2 variation in households (2022) (1)
- Human KIR+CD8+ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19 (2021) (1)
- Precursor-Directed Biosynthesis of Polyketide and Nonribosomal Peptide Natural Products (2013) (1)
- SOLUTION STRUCTURE OF THE HOLO-FORM OF THE FRENOLICIN ACYL CARRIER PROTEIN, MINIMIZED MEAN STRUCTURE (2003) (0)
- Oxygen-Dependent Promoter of the Vitreoscilla Hemoglobin Gene in Escherichia coli (0)
- Role of transglutaminase 2 in celiac disease pathogenesis (2012) (0)
- Structure of Thioesterase from DEBS with a thioesterase-specific antibody (2018) (0)
- Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4 (2003) (0)
- Mo1985 – Minimally-Invasive Monitoring of Intestinal Villous Health in Recovering Celiac Disease Patients (2019) (0)
- Properties of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase. (2021) (0)
- Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #2, mutant D422I (2004) (0)
- Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase (2007) (0)
- A Peptide Inhibitor Reveals an Extended Conformation of Transglutaminase 2 (2006) (0)
- Enzyme treatment of foods for celiac disease (2003) (0)
- Analysis of a “Split-and-Stuttering” Module of an Assembly Line Polyketide Synthase (2021) (0)
- Macrolides and Antifungals via Biotransformation (2014) (0)
- The Actinorhodin Ketosynthase/Chain Length Factor (2004) (0)
- Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10 (2020) (0)
- Trans-acting transferase from Disorazole synthase (2011) (0)
- Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0 (2003) (0)
- Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #1 (2004) (0)
- Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference (2023) (0)
- Better than Sliced Bread (2011) (0)
- Intracellular TG2 Activity Increases Microtubule Stability but is not Sufficient to Prompt Neurite Growth (2016) (0)
- Heterologist preparation of polycetides (2001) (0)
- The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study design of a multi-center pragmatic platform trial (2021) (0)
- Quantification of ALV003-Mediated Gluten Degradation Using Mass Spectrometry (2011) (0)
- Trans-acting transferase from Disorazole synthase complexed with Citrate. (2018) (0)
- Docking Model for MAT and ACP (2003) (0)
- Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2). (2022) (0)
- 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: ""turnstile closed"" state (TE-free) (2021) (0)
- Biotin and propionyl-CoA bound to Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB) (2004) (0)
- FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant (2003) (0)
- The Diversity of Nuclear Magnetic Resonance Spectroscopy (2009) (0)
- Polyketide synthase enzyme, and recombinant DNA constructs for the production of related FK-506 and FK-520 compounds (1999) (0)
- Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase (2020) (0)
- 598 – Identification of Immunotoxic Peptides from Dietary Wheat in Human Urine (2019) (0)
- The effect of oligosaccharides on glycoprotein stability (1995) (0)
- Reviews and comment from the nature publishing group (2004) (0)
- Cell-free synthesis of polyketide (1996) (0)
- Cloned Hemoglobin Genes Enhance Growth Of Cells (1991) (0)
- PL-14 Structure, Mechanism and Engineering of Polyketide Synthases (2006) (0)
- Effects and Implications for Celiac Disease Histamine-Gliadin Complexes: Biological Formation and Cleavage of Tissue Transglutaminase-Mediated (2005) (0)
- An old dog in search of new ticks (1997) (0)
- Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS) (2007) (0)
- Trans-acting transferase from Disorazole synthase with malonate (2018) (0)
- Crystal Structure of SCO1815: a Beta-Ketoacyl-Acyl Carrier Protein Reductase from Streptomyces coelicolor A3(2) (2007) (0)
- Evaluation of acebilustat, a selective inhibitor of leukotriene B4 biosynthesis, for treatment of outpatients with mild-moderate COVID-19 disease: A randomized, double-blind, placebo- controlled Phase 2 trial. (2023) (0)
- Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6 (2003) (0)
- 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1 (2021) (0)
- POSTER PRESENTATIONS; EVIDENCE FOR TRANSCRIPTIONAL REGULATION OF THE GLUCOSE-6-PHOSPHATE TRANSPORTER BY HIF-1ALPHA: TARGETING G6PT WITH MUMBAISTATIN ANALOGS IN HYPOXIC MESENCHYMAL STROMAL CELLS (2010) (0)
- Trans-acting transferase from Disorazole synthase solved by serial femtosecond XFEL crystallography (2018) (0)
- LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens. (2022) (0)
- Part III: Erythromycin Biosynthesis Biochemical Approaches (2007) (0)
- Crystal structure of recombinant barley cysteine endoprotease B isoform 2 (EP-B2) in complex with leupeptin (2006) (0)
- 6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2 (2021) (0)
- Natural Product Biosynthesis: A New Interface Between Enzymology and Medicine (2001) (0)
- 50 Years Ago in TheJournalofPediatrics: Association of Type 1 Diabetes Mellitus and Celiac Disease: Then and Now. (2021) (0)
- Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #3 (2004) (0)
- Adn recombonante method to produce oxygen binding proteins, particularly hemoglobins. (1988) (0)
- Mo1045 - Simvastatin as a Biomarker for Intestinal Villous Health for Recovering Celiac Disease Patients (2018) (0)
- An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease (2022) (0)
- A Selective Leukotriene B4 Antagonist, Acebilustat, for Treatment of Outpatients With COVID-19 Disease: A Randomized, Double-blind, Placebo-controlled Phase 2 Trial (2023) (0)
- Homology Model of Streptomyces coelicolor actinorhodin ketosynthase/chain length factor pair (2003) (0)
- Trans-acting transferase from Disorazole synthase in complex with Acetate (2011) (0)
- Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE), pH 8.5 (2003) (0)
- Sa1313 Simvastatin Metabolism by Small Intestinal CYP3A4 as a Non-Invasive Biomarker for the Diagnosis and Routine Monitoring of Celiac Disease (2012) (0)
- Structure, Mechanism and Engineering of Polyketide Synthases (2006) (0)
- Reviews and comment from the nature publishing group (2003) (0)
- Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) (2018) (0)
- Editorial overview: Next-generation therapeutics: Breaking new ground and making a difference for patients. (2016) (0)
- A diagnostic method for celiac (2003) (0)
- Architecture of Whole-Module and Bimodular Proteins from the 6-Deoxyerythronolide B Synthase (2014) (0)
- Overview and Introduction (2020) (0)
- Environmental Control Of A Genetic Process (1991) (0)
- Method of diagnosing celiac disease (2003) (0)
- Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 2G10 (2020) (0)
- Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS. (2006) (0)
- Engineering of novel polyketides. Progress and Prospects. (1996) (0)
- Minimized mean solution structure of the acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS) (2007) (0)
- Peptide Naturally Formed by Gastrointestinal Lesion-Derived T Cells of a 33-Mer Gliadin Antigen Presentation to Celiac (2004) (0)
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