Charalabos H. Pothoulakis

Charalabos H. Pothoulakis's AcademicInfluence.com Rankings

Philosophy

#6286

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#9296

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Logic

#3464

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#4624

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philosophy Degrees

Charalabos H. Pothoulakis

Biology

#8520

World Rank

#11612

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Physiology

#237

World Rank

#437

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Neuroscience

#1181

World Rank

#1223

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biology Degrees

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Philosophy
Biology

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Charalabos H. Pothoulakis's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Principles and clinical implications of the brain–gut–enteric microbiota axis (2009) (984)
Clostridium difficile colitis. (1994) (557)
Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms (2011) (548)
Mechanisms and metabolic implications of regional differences among fat depots. (2013) (500)
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. (2014) (423)
Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. (1988) (411)
Saccharomyces boulardii Protease Inhibits the Effects of Clostridium difficile Toxins A and B in Human Colonic Mucosa (1999) (402)
Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. (1995) (370)
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro. (1995) (350)
Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. (2007) (350)
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. (2007) (340)
Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. (1998) (304)
Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. (1993) (299)
Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin. (1991) (285)
CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. (1994) (285)
Intravenous immunoglobulin therapy for severe Clostridium difficile colitis (1997) (277)
Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. (2005) (272)
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. (2005) (254)
Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells. (1996) (253)
Neuropeptide substance P and the immune response (2016) (252)
Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum (1996) (249)
Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders (2012) (248)
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. (2003) (234)
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. (2005) (234)
Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficileToxin A in Mice (2001) (233)
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. (2000) (212)
MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. (2013) (210)
Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit. (1994) (203)
Differential effects of Clostridium difficile toxins A and B on rabbit ileum. (1987) (200)
Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins. (2001) (194)
Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. (2006) (191)
Clostridium difficile toxin B disrupts the barrier function of T84 monolayers. (1992) (188)
Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis. (1998) (187)
Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. (1997) (185)
Diminished Clostridium difficile toxin A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor. (1992) (174)
Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum. (1994) (173)
Role of neuropeptides in inflammatory bowel disease (2007) (166)
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. (2008) (151)
Review article: anti‐inflammatory mechanisms of action of Saccharomyces boulardii (2009) (149)
Saccharomyces boulardii Inhibits ERK1/2 Mitogen-activated Protein Kinase Activation Both in Vitro and in Vivo and Protects against Clostridium difficile Toxin A-induced Enteritis* (2006) (139)
Serum and Colonic Mucosal Immune Markers in Irritable Bowel Syndrome (2012) (138)
Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. (1998) (133)
The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition (2010) (132)
Neurotensin is a proinflammatory neuropeptide in colonic inflammation. (1999) (131)
Protein Kinase C Signaling Regulates ZO-1 Translocation and Increased Paracellular Flux of T84 Colonocytes Exposed toClostridium difficile Toxin A* (2002) (131)
Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine (1999) (126)
Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor binding. (1992) (122)
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. (2002) (119)
Metalloproteinases and Transforming Growth Factor-α Mediate Substance P-induced Mitogen-activated Protein Kinase Activation and Proliferation in Human Colonocytes* (2004) (119)
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. (2011) (116)
Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes. (1988) (115)
Signal Transduction Pathways Mediating Neurotensin-stimulated Interleukin-8 Expression in Human Colonocytes* (2001) (115)
Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract (1997) (114)
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A. (1996) (113)
Epidermal Growth Factor Receptor Transactivation Mediates Substance P-induced Mitogenic Responses in U-373 MG Cells* (2000) (113)
Clostridium difficile toxin A causes early damage to mitochondria in cultured cells. (2000) (113)
Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells. (1998) (113)
Effects of Clostridium difficile Toxins on Epithelial Cell Barrier (2000) (112)
MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. (2015) (112)
Colonic mucin release in response to immobilization stress is mast cell dependent. (1998) (112)
Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins (1996) (111)
Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. (2011) (109)
American Journal of Physiology: Gastrointestinal and Liver Physiology American Journal of Physiology: Heart and Circulatory Physi- QlQgY American Journal of Physiology: Regulatory, Integrative and Comparative Physiology American Journal of Physiology: Renal, Fluid and Electrolyte (2003) (108)
gp96 Is a Human Colonocyte Plasma Membrane Binding Protein for Clostridium difficile Toxin A (2008) (106)
Comparative study of Clostridium difficile toxin A and cholera toxin in rabbit ileum. (1989) (105)
Role of MyD88 in Phosphatidylinositol 3-Kinase Activation by Flagellin/Toll-like Receptor 5 Engagement in Colonic Epithelial Cells* (2006) (103)
Adipose Tissue and Inflammatory Bowel Disease Pathogenesis (2012) (102)
Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum. (1993) (102)
Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin B (1995) (102)
Immunomodulatory Properties of Substance P (2006) (102)
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation (2007) (100)
Substance P Stimulates Cyclooxygenase-2 and Prostaglandin E2 Expression through JAK-STAT Activation in Human Colonic Epithelial Cells1 (2006) (98)
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. (2005) (97)
Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. (2002) (95)
IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. (1997) (94)
The effects of acute and chronic psychological stress on bladder function in a rodent model. (2011) (94)
C. difficile toxin A increases intestinal permeability and induces Cl- secretion. (1990) (94)
Clostridium difficile Toxin A Regulates Inducible Cyclooxygenase-2 and Prostaglandin E2 Synthesis in Colonocytes via Reactive Oxygen Species and Activation of p38 MAPK* (2005) (94)
Pathogenesis of Clostridium difficile-associated diarrhoea. (1996) (93)
Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. (2009) (91)
Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis (2011) (91)
MEK Is a Key Modulator for TLR5-induced Interleukin-8 and MIP3α Gene Expression in Non-transformed Human Colonic Epithelial Cells* (2004) (90)
Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. (2003) (89)
Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-κB site on its promoter (2003) (88)
The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice (2012) (86)
Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins (2011) (86)
Antimicrobial peptides and colitis. (2012) (85)
Characterization of rabbit ileal receptors for Clostridium difficile toxin A. Evidence for a receptor-coupled G protein. (1991) (85)
A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats. (1996) (84)
Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum. (2002) (83)
Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins. (1998) (82)
A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. (2016) (81)
TRIF Mediates Toll-like Receptor 5-induced Signaling in Intestinal Epithelial Cells* (2010) (80)
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. (2006) (80)
Purification and properties of Clostridium difficile cytotoxin B. (1986) (79)
Clostridium difficile colitis and diarrhea. (1993) (79)
Clostridial toxins (2012) (77)
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. (2002) (77)
Clostridium difficile toxin A-induced microvascular dysfunction. Role of histamine. (1994) (76)
Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2α (2007) (74)
Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand. (2007) (73)
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. (2012) (73)
Corticotropin-Releasing Hormone Receptor 2-Deficient Mice Have Reduced Intestinal Inflammatory Responses1 (2006) (73)
Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation (2006) (72)
Effects of substance P on human colonic mucosa in vitro. (1999) (72)
Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation (2005) (70)
Rifalazil Treats and Prevents Relapse of Clostridium difficile-Associated Diarrhea in Hamsters (2004) (68)
Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction. (2003) (67)
Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis. (2010) (65)
Substance P as a novel anti-obesity target. (2008) (64)
Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor (2007) (64)
Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. (2008) (64)
Substance P modulates colitis-associated fibrosis. (2010) (63)
Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis (2009) (63)
Metalloproteinase-dependent Transforming Growth Factor-α Release Mediates Neurotensin-stimulated MAP Kinase Activation in Human Colonic Epithelial Cells* (2004) (62)
Neuroimmune Mechanisms of Intestinal Responses to Stress: Role of Corticotropin‐Releasing Factor and Neurotensin (1998) (62)
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation. (2004) (62)
Substance P receptor expression in intestinal epithelium in clostridium difficile toxin A enteritis in rats. (1998) (62)
Protective effects of neurokinin‐1 receptor during colitis in mice: role of the epidermal growth factor receptor (2002) (61)
Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. (2009) (60)
Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice. (2012) (60)
Melanin-concentrating hormone as a mediator of intestinal inflammation (2008) (60)
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis (2014) (59)
Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. (2011) (59)
A MicroRNA Signature in Pediatric Ulcerative Colitis: Deregulation of the miR-4284/CXCL5 Pathway in the Intestinal Epithelium (2015) (57)
IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells. (1994) (55)
Obesity, innate immunity and gut inflammation (2007) (55)
Clostridium difficile Toxin A Decreases Acetylation of Tubulin, Leading to Microtubule Depolymerization through Activation of Histone Deacetylase 6, and This Mediates Acute Inflammation* (2010) (55)
Ultrastructural effects of Clostridium difficile toxin B on smooth muscle cells and fibroblasts. (1983) (54)
Ghrelin stimulates interleukin‐8 gene expression through protein kinase C‐mediated NF‐κB pathway in human colonic epithelial cells (2006) (53)
Comparative Efficacies of Rifaximin and Vancomycin for Treatment of Clostridium difficile-Associated Diarrhea and Prevention of Disease Recurrence in Hamsters (2008) (53)
Clostridium difficile toxin A excites enteric neurones and suppresses sympathetic neurotransmission in the guinea pig (2000) (53)
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. (2007) (52)
The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. (2006) (52)
Nitric oxide inhibits rat intestinal secretion by Clostridium difficile toxin A but not Vibrio cholerae enterotoxin. (1996) (51)
Leptin mediates Clostridium difficile toxin A-induced enteritis in mice. (2003) (51)
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. (2005) (51)
Altered ion channel activity in murine colonic smooth muscle myocytes in an experimental colitis model. (2000) (50)
Functional role and therapeutic targeting of microRNAs in inflammatory bowel disease. (2018) (50)
CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis. (1998) (50)
Neurotensin—regulated miR-133α is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis (2014) (48)
Neurotensin stimulates Cl(-) secretion in human colonic mucosa In vitro: role of adenosine. (2000) (48)
Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A. (2001) (48)
Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. (2009) (47)
Endocannabinoids in the gastrointestinal tract. (2016) (47)
Clostridium difficile Toxin A-induced Microvascular Dysfunction (1994) (46)
A Novel Peroxisome Proliferator-activated Receptor (PPAR)γ Agonist 2-Hydroxyethyl 5-chloro-4,5-didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis* (2015) (46)
Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro (1999) (44)
Epithelial Cell IκB-Kinase β Has an Important Protective Role in Clostridium difficile Toxin A-Induced Mucosal Injury1 (2006) (44)
Insulin-like Growth Factor-1 Receptor Transactivation Modulates the Inflammatory and Proliferative Responses of Neurotensin in Human Colonic Epithelial Cells* (2011) (44)
Neurotensin Stimulates Interleukin-8 Expression through Modulation of IκBα Phosphorylation and p65 Transcriptional Activity: Involvement of Protein Kinase Cα (2005) (43)
Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis. (2008) (43)
Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis. (2008) (42)
A receptor decoy inhibits the enterotoxic effects of Clostridium difficile toxin A in rat ileum. (1996) (42)
Substance P, obesity, and gut inflammation (2009) (41)
IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum. (1997) (41)
Human Monoclonal Antibodies against Clostridium difficile Toxins A and B Inhibit Inflammatory and Histologic Responses to the Toxins in Human Colon and Peripheral Blood Monocytes (2013) (41)
Participation of reactive oxygen metabolites in Clostridium difficile toxin A-induced enteritis in rats. (1999) (41)
A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. (2003) (41)
Macrophage-dependent stimulation of T cell-depleted spleen cells by Clostridium difficile toxin A and calcium ionophore. (1990) (40)
Diet-Induced Obesity Promotes Colon Tumor Development in Azoxymethane-Treated Mice (2013) (39)
Neurotensin stimulates expression of early growth response gene‐1 and EGF receptor through MAP kinase activation in human colonic epithelial cells (2007) (39)
TRIF Modulates TLR5-dependent Responses by Inducing Proteolytic Degradation of TLR5* (2010) (39)
[Recent advances in Saccharomyces boulardii research]. (2010) (38)
The Insect Peptide Coprisin Prevents Clostridium difficile-Mediated Acute Inflammation and Mucosal Damage through Selective Antimicrobial Activity (2011) (38)
Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis (2018) (38)
Protein Kinase C Signaling Regulates ZO-1 Translocation and Increased Paracellular Flux of T84 Colonocytes Exposed to Clostridium difficile Toxin A* (2002) (37)
Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. (2011) (37)
Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis (2014) (37)
Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. (2002) (37)
Rho GTPases as therapeutic targets for the treatment of inflammatory diseases (2003) (36)
Interleukin-6 Genetic Ablation Protects from Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice (2006) (36)
Effects of purified Clostridium difficile toxin A on rabbit distal colon. (1995) (36)
Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α–miR-210 Signaling (2016) (34)
Clostridium difficile toxin B activates calcium influx required for actin disassembly during cytotoxicity. (1995) (32)
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1. (2015) (32)
Epidermal growth factor attenuates Clostridium difficile toxin A- and B-induced damage of human colonic mucosa. (1997) (32)
Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis. (2010) (31)
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. (2006) (31)
Neurotensin-induced Proinflammatory Signaling in Human Colonocytes Is Regulated by β-Arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1* (2012) (31)
Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice (2008) (30)
Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling. (2015) (30)
Substance P Mediates Proinflammatory Cytokine Release From Mesenteric Adipocytes in Inflammatory Bowel Disease Patients (2015) (29)
Chronic unpredictable stress regulates visceral adipocyte‐mediated glucose metabolism and inflammatory circuits in male rats (2014) (29)
The neurotensin-HIF-1α-VEGFα axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis. (2014) (29)
The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. (2009) (29)
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. (2011) (29)
Clostridium difficile cytotoxin inhibits protein synthesis in fibroblasts and intestinal mucosa. (1986) (29)
Inhibition of Vasoactive Intestinal Polypeptide (VIP) Induces Resistance to Dextran Sodium Sulfate (DSS)-Induced Colitis in Mice (2014) (28)
The Insect Peptide CopA3 Increases Colonic Epithelial Cell Proliferation and Mucosal Barrier Function to Prevent Inflammatory Responses in the Gut* (2015) (28)
Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. (2011) (28)
Identification of a Functional TPH1 Polymorphism Associated With Irritable Bowel Syndrome Bowel Habit Subtypes (2013) (27)
The neurotensin receptor‐1 promotes tumor development in a sporadic but not an inflammation‐associated mouse model of colon cancer (2012) (27)
Genome‐wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome (2016) (27)
Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats. (2001) (27)
SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS. (2013) (27)
Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice. (2014) (26)
Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis (2015) (26)
CRHR2/Ucn2 signaling is a novel regulator of miR‐7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas‐mediated apoptosis (2018) (26)
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin. (2009) (26)
Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice. (2009) (25)
Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk (2019) (25)
A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile toxin A in rat colon. (1996) (25)
Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha. (2005) (25)
Neuropeptides, Mesenteric Fat, and Intestinal Inflammation (2008) (24)
Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. (2016) (24)
MicroRNA-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis. (2017) (23)
Endothelin-converting Enzyme 1 and β-Arrestins Exert Spatiotemporal Control of Substance P-induced Inflammatory Signals* (2014) (23)
Substance P receptor expression in intestinal epithelium in Clostridium difficile toxin A enteritis in rats. (1998) (22)
Analysis of endogenous lipids during intestinal wound healing (2017) (21)
Identification of a Novel Substance P–Neurokinin-1 Receptor MicroRNA-221-5p Inflammatory Network in Human Colonic Epithelial Cells (2015) (21)
Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation. (2019) (21)
The chemotactic response of human granulocytes to Clostridium difficile toxin A is age dependent. (1991) (20)
The IBD associated long non-coding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation. (2019) (19)
Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis. (2016) (19)
Fidaxomicin Inhibits Clostridium difficile Toxin A-Mediated Enteritis in the Mouse Ileum (2014) (19)
Serotonin has a critical role in the pathogenesis of experimental colitis. (2009) (18)
Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells. (2011) (18)
MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells. (2019) (18)
microRNA-24 Is Elevated in Ulcerative Colitis Patients and Regulates Intestinal Epithelial Barrier Function. (2019) (18)
Effect of purified Clostridium difficile toxins on intestinal smooth muscle. II. Toxin B. (1989) (18)
Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. (2018) (18)
Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes. (2009) (17)
Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway* (2015) (16)
Urocortins and CRF receptor type 2 variants in the male rat colon: gene expression and regulation by endotoxin and anti-inflammatory effect. (2016) (15)
Development of Microbial-Human Enterocyte Interaction: Cholera Toxin (2003) (15)
Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy (2016) (14)
Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B-Mediated Inflammatory Responses via Inhibition of NF-κB Activity (2017) (13)
Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat (2015) (13)
Role and Mechanisms of Exosomal miRNAs in IBD Pathophysiology. (2020) (13)
Substance P causes a chloride-dependent short-circuit current response in rabbit colonic mucosa in vitro. (1999) (13)
Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis (2012) (13)
The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p and MicroRNA-338-3p, are Downregulated in Irritable Bowel Syndrome and are Associated with Barrier Function and MAPK signaling. (2021) (13)
Clostridium difficile-associated diarrhea and colitis: pathogenesis and therapy. (1993) (12)
Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice. (2018) (12)
Effects of substance P on human colonic mucosa in vitro. (1999) (12)
Novel approaches to treating Clostridium difficile-associated colitis (2016) (12)
Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease. (2018) (12)
Title A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS 1 as an enhancer of inflammation (2016) (12)
Effect of purified Clostridium difficile toxins on intestinal smooth muscle. I. Toxin A. (1989) (11)
Effects of purified Clostridium difficile toxin A in the small intestine of the rat in vivo. (1993) (11)
Participation of reactive oxygen metabolites in Clostridium difficile toxin A-induced enteritis in rats. (1999) (10)
Saccharomyces boulardii protease inhibits Clostridium difficile toxin a and b-induced effects in human colonic mucosa (1998) (9)
Diminished Expression of Corticotropin-Releasing Hormone Receptor 2 in Human Colon Cancer Promotes Tumor Growth and Epithelial-to-Mesenchymal Transition via Persistent Interleukin-6/Stat3 Signaling (2015) (8)
Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin (2016) (8)
Mesenteric Adipose-derived Stromal Cells From Crohn’s Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis (2018) (8)
The role of neuroenteric hormones in intestinal infectious diseases. (2000) (8)
MicroRNA-133α regulates neurotensin-associated colonic inflammation in colonic epithelial cells and experimental colitis. (2015) (8)
Role of G protein-coupled receptors-microRNA interactions in gastrointestinal pathophysiology. (2017) (8)
Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition. (2020) (7)
The therapeutic mechanism macrophage inflammatory protein 1 alpha (MIP-1α/CCL3) neutralizing antibody in Clostridium difficile infection in mice. (2019) (7)
Tu1197 MicroRNA-4284 Regulates CXCL5 Expression and Is Down-Regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis (2014) (7)
Posttranslational modifications as therapeutic targets for intestinal disorders. (2021) (7)
Autotaxin loss accelerates intestinal inflammation by suppressing TLR4‐mediated immune responses (2020) (6)
miR-24 Is Elevated in Ulcerative Colitis Patients and Regulates Intestinal Epithelial Barrier Function (6)
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR. (2019) (6)
IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. (1997) (5)
In vitro evidence that rabbit distal colonic muscularis mucosae has a Clostridium difficiletoxin A receptor. (1998) (5)
Mo1855 Zolpidem Confers Disease Susceptibility to Clostridium difficile Infection (2015) (5)
1090 - Epigenetic Changes in Blood Cells and Colonic Mucosa are Associated with Irritable Bowel Syndrome (IBS) (2018) (5)
EGF receptor transactivation mediates SP-induced mitogenic responses in U-373 MG cells (2000) (4)
In vitro evidence that rabbit distal colonic muscularis mucosae has a Clostridium difficile toxin A receptor. (1998) (4)
Oligosaccharides containing sialic acid and N-acetylglucosamine mediate Clostridium difficile toxin B (TxB) binding and biologic effects in human colonic mucosa (1998) (4)
783 TL1A Modulates the Differential Effect of IL-17 Blockade on Mucosal Inflammation (2014) (4)
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain (2022) (4)
CP-96,345, a specific substance P receptor antagonist inhibits rat intestinal responses to toxin A, but not cholera toxin. (1994) (4)
Dysregulation of the Long-Noncoding RNA, Ghrlos, in Irritable Bowel Syndrome (2017) (4)
196 Identification of a Novel Substance P (SP)-Neurokinin-1 Receptor (NK-1R) MicroRNA-221 Inflammatory Network in Human Colonic Epithelial Cells (2014) (4)
Gene Expression Profiling Identifies CDKN2B-AS1 as a Long Non-Coding RNA Associated with IBD and Regulated by TGF-Beta (2017) (3)
Therapeutic Mechanism of Macrophage Inflammatory Protein 1 α Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice (2020) (3)
Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation (2021) (3)
998 Glucocorticoid Receptor Gene Methylation is a Potential Biomarker of Irritable Bowel Syndrome (2012) (3)
Neuropeptide - adipose tissue communication and intestinal pathophysiology. (2011) (3)
Bacterial infections: small intestine and colon. (2003) (3)
Increased neurotensin receptor (NTR) mRNA in the colonic mucosa during clostriudium difficile pseudomembranous colitis (PMC) in humans (1998) (3)
CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis. (1998) (3)
Saccharomyces boulardii inhibits Clostridium difficile toxin A receptor binding and enterotoxic effect in rat ileum. (1993) (2)
Toxin A-Induced Mucosal Injury difficile Clostridium Important Protective Role in Has an β B-Kinase κ Epithelial Cell (2006) (2)
Clostridium diflicile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers (1989) (2)
Long Non-Coding RNA (LNCRNA) Profiling Reveals Overexpression of UCA1 and CCAT1 in Human Colonocytes Stimulated by Neurotensin and in Colonic Mucosal Tissues from Ulcerative Colitis (UC) Patients (2017) (2)
Gastrointestinal , Hepatobiliary , and Pancreatic Pathology Constitutive TL 1 A Expression under Colitogenic Conditions Modulates the Severity and Location of Gut Mucosal Inflammation and Induces Fibrostenosis (2012) (2)
Rat Intestinal Epithelial Cells ProductionMacrophage-Inflammatory Protein-2 Toxin A Stimulates Clostridium difficile (1998) (2)
Human Anti-Gal IgG binds to the same receptor and mimics the effects of C. difficile in rat colon. (1996) (2)
Intravenous immunoglobulin therapy for severe Clostridium di Y cile colitis (1998) (2)
Neurotensin stimulates interleukin-8 expression in human colonic epithelial cells through Rho GTPase-mediated NFkappaB pathways (2003) (2)
Rifalazil prevents and treats Clostridium difficile-associated infection in hamsters (2003) (2)
IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed monocytes (1995) (2)
Neurotensin (NT) induces chloride secretion in human colonic mucosa through an adenosine-dependent pathway (1998) (2)
985 - Human Long Non-Coding RNA (LNCRNA) CCAT1 and UCA1 Regulate Proinflammatory Response and Cell Migration in Human and Mouse Intestinal Epithelial Cells (2018) (2)
Diminished intestinal inflammatory and secretory responses in substance P (SP) receptor (NK-1R) deficient mice* (1998) (2)
Increased neurotensin receptor (NTR) mRNA in colonic mucosa of patients with irritable bowel disease (IBS) (1998) (2)
Enterotoxin A of Clostridium difficile and alpha-Gal epitopes. (1999) (2)
IL-1β stimulates release of substance P (SP) and neurotensin (NT) and increases expression of their receptors on lamina propria macrophages (LPMS)* (1998) (1)
Chapter 171 – Neurotensin (2013) (1)
1093 Identification and Characterization of Colonic-Exosomes: micro-RNA Mediated Horizontal Gene Transfer Within the Colonic Epithelia In Vitro and In Vivo (2016) (1)
Colonic mucin release in response to immobilization stress is mast cell dependent. (1998) (1)
Cytoprotective role of heat shock protein 72 (HSP72) against Clostridium difficile toxin A-induced intestinal epithelial cell injury (2000) (1)
Corticotropin releasing hormone (CRH) is a proinflammatory peptide in mouse ileum (2001) (1)
547 Effects of Substance P on Pro and Anti-Inflammatory Responses of Human Mesenteric Preadipocytes Isolated From IBD Patients (2013) (1)
Corticotropin-Releasing Hormone Receptor Alters the Tumor Development and Growth in Apcmin/+ Mice and in a Chemically-Induced Model of Colon Cancer (2021) (1)
Clostridium difficile toxin-induced IL-8 release by monocytes follows tyrosine kinase, NF-kB and NF-IL6 activation (1998) (1)
Erratum: Sustained TL1A (TNFSF15) expression on both lymphoid and myeloid cells leads to mild spontaneous intestinal inflammation and fibrosis (DOI: 10.1556/EuJMI.3.2013.1.2). (2013) (1)
Tu1680 Preadipocyte-Specific Effects on Human Colonocyte Proinflammatory Responses Are Obesity and IBD-Dependent (2013) (1)
Infectious Pathogens and the Neuroenteric System (2003) (1)
M1201 Bacillus Polyfermenticus, a Novel Probiotic Microbe, Ameliorates Colonic Inflammation in Experimental Colitis Models via TLR2 and TLR4 (2008) (1)
Leptin plays an anti-inflammatory role in acute pancreatitis (2003) (1)
Correction: Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation (2022) (1)
Ammonia inhibits regulated chloride secretion in in vitro human colon (1998) (1)
A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS 1 as an enhancer of inflammation A long noncoding RNA signature in Ulcerative Colitis (2016) (1)
Substance P-Induced Colonic Epithelial Cell-Secreted Exosomes Exacerbate Experimental Colitis and Regulate Cell Proliferation and Migration via Exosomal MIR-21 (2017) (1)
Clostridium difficile toxin A stimulates enzyme secretion from isolated rat pancreatic acini. (1993) (1)
Here to Heal: Mucosal CD74 Signaling in Colitis (2020) (1)
Immobilized oligosaccharides bind Clostridium difficile toxin B and diminish its effects in human colon (2000) (1)
Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis (2015) (1)
Tu2038 Chronic Stress Increases Systemic and Fat Depot Cytokine Levels and Induces Inflammation-Associated Signaling Cascades in Adipocytes (2012) (1)
Differentiating functional roles of gene expression from immune and non-immune cells in mouse colitis by bone marrow transplantation. (2012) (1)
Mechanisms of Saccharomyces boulardii on Clostridium difficile infection (1996) (1)
Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative response of neurotensin in human colonic epithelial cells (2010) (1)
Effects of a neurokinin-1 receptor (NK-1R) antagonist on colon cancer through suppression of colon tumor-initiating cells. (2011) (1)
Silence Please!: siRNA approaches to tighten the intestinal barrier in vivo. (2013) (1)
Tu1838 Pharmacological Inhibition of Phosphatase and Tensin Homologue (Pten) Elicits Colitis in IL-10-KO Mice (2016) (0)
Neuropeptide substance P and the immune response (2016) (0)
Su1903 The Trans-Golgi Network Protein Aftiphilin Is Involved in Regulation of Intestinal Epithelial Permeability in Colonic Epithelial Cells (2015) (0)
Early mitochondrial damage by Clostridium difficile toxin A (TXA) regulates release of interleukin-8 from human colonocytes (2000) (0)
Early intracellular signalling of Clostridium difficile toxin a (TXA) in rat ileum involves a protein tyrosine kinase-dependent pathway (1998) (0)
Moderate Alcohol Drinking: Effects on the Heart and Liver (2000) (0)
Mo1730 The Jasmonate Analogue 2-Hydroxyethyl 5-Chloro-4,5-Didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis (2015) (0)
636 UNRAVELLING THE MOLECULAR MECHANISM RESPONSIBLE FOR THE SELECTIVE SORTING OF MICRORNA-21 INTO THE SUBSTANCE PINDUCED COLONIC EPITHELIAL EXOSOMES (2020) (0)
Neurotensin (NT) Receptor 1 (Ntr1)-MicroRNA Networks in Human Colon Epithelial Cells. Characterization of Novel Pathways Connecting Neurotensin and Tumor Growth (2011) (0)
The role of the I kappa B kinases in the substance P-induced inflammation of the GI tract (2003) (0)
Tu1823 MiR-133a Regulates the Endocytosis of a G Protein-Coupled Receptor in Human Colonocytes (2012) (0)
T1174 The Neurotensin Receptor-1 Promotes Tumor Development in a Sporadic but Not an Inflammation-Associated Mouse Model of Colorectal Cancer (2010) (0)
M1772 TRIF Adaptor Molecule Mediates MyD88-Independent Signaling of Toll-Like Receptor5 (2010) (0)
Mo1569 IDENTIFICATION OF COLONIC MUCOSAL MICRORNAS ALTERED IN IRRITABLE BOWEL SYNDROME AND THEIR ROLES IN INTESTINAL BARRIER FUNCTION. (2020) (0)
Substance P and adenosine signaling pathways regulate exosomal sorting of miR-21 in colonic epithelial cells (2022) (0)
Tu1839 miR-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis (2016) (0)
Substance P Induces Angiogenic Factor CCN1 Expression via Histone Deacetylase Activity in Human Colonic Epithelial Cells (2011) (0)
Fidaxomicin and OP1118 Inhibit C. Difficile Toxin A- and Bmediated Inflammatory Responses via Inhibition of NF-KB Activity (2017) (0)
14 COLONIC EPITHELIAL CELL-SPECIFIC AFTIPHILIN KNOCKDOWN REGULATES EPITHELIAL BARRIER FUNCTION THROUGH MYOSIN LIGHT CHAIN-ASSOCIATED ACTIN ORGANIZATION IN VITRO AND INTESTINAL LENGTH IN VIVO (2020) (0)
Corticotropin-Releasing Hormone Receptor 2 (CRHR2) Mediates Enteric Glial Cell Function During Colitis (2017) (0)
347 Targeting a microRNA for the Therapy of Colitis-Associated Colorectal Cancer (2015) (0)
Tu1635 Protection of the Enteric Nervous System in Colitis: A Therapeutic Approach for Ibd? (2013) (0)
Efficacy of rifaximin vs. vancomycin for treatment of Clostridium difficile-associated 1 diarrhea and prevention of disease recurrence in hamsters 2 Rifaximin for Clostridium difficile-associated diarrhea 3 4 (2008) (0)
W1753 Substance P Decreases Insulin-Induced Glucose Uptake in Adipocytes (2008) (0)
1098 COLONIC EPITHELIAL CELL-SPECIFIC AFTIPHILIN (AFTPH) REGULATES ACTIN ORGANIZATION THROUGH REGULATING F-ACTIN/G-ACTIN RATIO IN VITRO AND INTESTINAL LENGTH IN VIVO (2020) (0)
154 Expression of Substance P (SP)-Regulated miR-31-3p Is Increased in Colitis and Modulates RhoA Expression in Human Colonic Epithelial Cells (2015) (0)
642 HIGH-THROUGHPUT SCREENING IDENTIFIED LORATADINE AND GENISTEIN AS EFFECTIVE REPURPOSED CANDIDATE DRUGS FOR TREATING CLOSTRIDIUM DIFFICILE INFECTION (2020) (0)
In vivo selection reveals long non-coding RNAs implicated in colon to liver metastasis (2022) (0)
198 Colonic MicroRNA-133α Promotes Neurotensin-Associated Proinflammatory Responses in Human Colonocytes and Experimental Colitis (2014) (0)
Tu1729 Neurotensin (NT) Through the Regulation of MicroRNA (miR)-210 Promotes the Development of Colitis and Intestinal Angiogenesis (2014) (0)
P-201 Neurotensin-HIF-1&agr;-microRNA-210 Axis Orchestrates Hypoxia, Colonic Inflammation and Intestinal Angiogenesis (2013) (0)
Hormones, Neurotransmitters, Growth Factors, Receptors, and Signaling MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells (2019) (0)
Inhibition of Vasoactive Intestinal Polypeptide (VIP) Induces Resistance to Dextran Sodium Sulfate (DSS)-Induced Colitis in Mice (2014) (0)
Sa1747 Antimicrobial Peptide Cathelicidin Inhibits Salmonella Mediated Intestinal Inflammation and Fibrosis (2014) (0)
Clostridium, Infection and Immunity (1998) (0)
136 Human Monoclonal Antibodies Against Clostridium difficile Toxin a and B Inhibit Inflammatory Responses and Epithelial Cell Damage to Toxins a and B in Human Peripheral Blood Monocytes and Human Colonic Tissues (2013) (0)
1687 THE EFFECTS OF ACUTE AND CHRONIC STRESS ON BLADDER STRUCTURE AND FUNCTION (2010) (0)
Mo1112 – Microrna-24 is Overexpressed in Ulcerative Colitis and Significantly Affects Intestinal Barrier Function (2019) (0)
735 Distinct Effects of IFN-γ and IL-17A on TL1A-Modulated Murine Regional Inflammation and Fibrosis (2013) (0)
22 NT Induces IL-6 Secretion in Mouse Preadipocytes and Adipose Tissues During TNBS Colitis (2008) (0)
Melanin-concentrating hormone as a mediator of intestinal inflammation you. Your matters (2008) (0)
207 A MicroRNA-Epigenetic Circuit Regulates Colon Cancer Stem Cells (2012) (0)
High Intestinal Cathelicidin Level Predicts Good Prognosis of Ulcerative Colitis Patients: P‐234 YI (2012) (0)
595 Deletion of Phosphatase and Tensin Homolog PTEN in the Intestinal Epithelium Causes Spontaneous Early-Onset Colitis in an IL-10 Deficient Environment (2014) (0)
Su1894 Identification of a Novel Function of Corticotropin Releasing Factor (CRH) in the Repair of Intestinal Epithelium in DSS Colitis (2015) (0)
Mo1117 – Gavage As-Mir-214-3P Reduces Inflammation in Experimental Colitis (2019) (0)
Mo1097 Increased SP Proinflammatory Responses in Human Mesenteric Preadipocytes Isolated From Ulcerative Colitis Patients (2012) (0)
Tu1919 Anti-Inflammatory Effects of Anti-Microbial Peptide Cathelicidin in Mice With Acute Colitis (2012) (0)
Tu1211 AN ANTISENSE OLIGONUCLEOTIDE FOR MICRORNA-24-3P EXHIBITS SAFE AND EFFICIENT KNOCKDOWN ABILITY IN VITRO AND IN VIVO AND INHIBITS TRINITROBENZENE SULFONIC ACID (TNBS) COLITIS (2020) (0)
Role of endogenous glucocorticoids on Clostridium difficile toxin a (TxA) enteritis (1998) (0)
Neuroimmune Interactions and Pathogenesis of Intestinal Inflammation in Infectious Diseases (2003) (0)
Receptor for activated C kinase (RACKI) mediates protein kinase C (PKC) signaling induced by Clostridium difficile toxin A (2003) (0)
T1712 Toll-Like Receptor 9 (TLR9) Mediated Cathelicidin Secretion from Colonocytes During Colonic Inflammation (2009) (0)
M1178 Inhibition of ERBB-Dependent Signaling by a Probiotic Bacterium Suppresses Tumor Growth Both In Vivo and In Vitro (2010) (0)
699 The Role of Endothelin Converting Enzyme 1 (ECE1) in Intestinal Inflammation (2009) (0)
T1774 Peripheral Knockdown of Calcitonin-Like Receptor (CLR) by RNAI Ameliorates Clostridium difficile Toxin a Enteritis: Involvement of TNFα and Perk Signaling Pathways (2010) (0)
AGA abstracts T1786–W1189 (2004) (0)
Su1288 Intestinal Cathelicidin Level Indicates Inflammatory Bowel Disease Activity and Mediates Anti-Inflammatory Effects in Colitis (2014) (0)
357 Reversal of Murine Colitis and Fibrosis by Neutralizing TL1A Antibody: Potential Novel Therapy to Alter Natural History of Crohn's Disease (2012) (0)
Su1905 Intestinal Adiponectin Receptor 1 (AdipoR1) Modulates Inflammation During Colitis: a Potential Link in Adipose Tissue-Intestinal Crosstalk During Inflammatory Bowel Disease (2015) (0)
916 Substance P Mediates Development of Colon Tumors in DSS-Exposed APC/Min Mice and Cultured Human Colon Cancer Cells (2008) (0)
Mo1872 Corticotropin-Releasing Hormone Receptor 2 (CRHR2) Inhibits Colorectal Cancer Immunoescape Through Regulation of Fas/FasL Signaling (2015) (0)
Expression Profiling of Sigmoid Biopsies in Irritable Bowel Syndrome vs Healthy Controls (2017) (0)
High Protein Diet Selectively Reduces Fat Mass and Improves Glucose Tolerance in Diet-Induced Obese (DIO) Rats (2011) (0)
198 Bitter Stimuli Induce ERK Activation in Mouse and Human Cell Lines (2012) (0)
Substance P-Regulated Microrna-31-3P Silencing Enhances Mucosal Repair following Colitis (2017) (0)
P-171 The Trans-Golgi Network Protein Aftiphilin Regulates Intestinal Epithelial Permeability in Human Colonic Epithelial Cells (2016) (0)
P020 COLONIC INHIBITION OF PHOSPHATASE AND TENSIN HOMOLOG (PTEN) INCREASES COLITOGENIC BACTERIA, INDUCING COLITIS IN IL10 DEFICIENT MICE (2018) (0)
Upregulation of neurokinin 1 (NK-1) receptors mediates pouch inflammation in a rat model of ileal j pouch-anal anastomosis (IPAA) (2000) (0)
Primary afferent sensory neurons and sensory neuropeptides mediate diarrhea and intestinal inflammation (0)
Tu1656 Anti-Fibrogenic Roles of Cathelicidin in Chronic Colitis Associated Colonic Fibrosis (2013) (0)
Sa1679 Effects of Urocortin 2 and Corticotropin-Releasing Hormone Receptor 2 in Colorectal Cancer Growth and Metastasis (2013) (0)
Anti-fibrogenic roles of cathelicidin in chronic colitis associated colonic fibrosis: P-231. (2011) (0)
Flagellin Stimulates IL-8 Production in Native Human Colon and Enhances Ongoing Colonic Inflammation in Mice (2005) (0)
Gastrointestinal , Hepatobiliary and Pancreatic Pathology Substance P-Mediated Expression of the Pro-Angiogenic Factor CCN 1 Modulates the Course of Colitis (2010) (0)
Sa1142 THE ROLE FOR LONG NON-CODING RNA IN COLORECTAL CANCER METASTASIS (2020) (0)
985 Substance P Mediates Colonic Fibrosis in Chronic Trinitrobenzene Sulfonic Acid (TNBS)-Treated Mice and Collagen Synthesis in Human Colonic Fibroblasts (2009) (0)
Substance P (SP)—Induced interleukin-8 (IL-8) gene upregulation involves AP-1 and NFkB-dependent pathways (2000) (0)
S1804 Modulation of Spinal Glia Activation and Glutamate Transmission in the Model of Chronic Water Avoidance Stress-Induced Visceral Hyperalgesia: Role of Glucocorticoids (2010) (0)
Hepatocyte growth factor stimulates epithelial restitution in rabbit duodenum in vitro (2004) (0)
Su1664 - Histone Deacetylase 7 Expression is Upregulated in Colonic Tissues from DSS-Induced Colitis Mice and from Patients with Active Ulcerative Colitis (2018) (0)
M2005 Truncated Neurokinin-1 Receptor Mediates Colon Cancer Development (2009) (0)
Tu1673 Corticotropin-Releasing Hormone Receptors Activate Inflammatory Pathways in Mesenteric Adipose Tissue (2013) (0)
C. difficile toxins A (TxA) and B (TXB) block phosphorylation of focal adhesion kinase (FAK) in chinese hamster ovary (CHO) and colonic adenocarcinoma (T84) cells (1998) (0)
1048 Mir-214 as a Therapeutic Target in Ulcerative Colitis (UC)-Associated Colon Cancer (2012) (0)
Epidermal growth factor attenuates Clostridium difficile toxin A- and B-induced damage of human colonic mucosa. (1997) (0)
Rho proteins and P38 map kinase are required for IL-8 gene expression induced by Clostridium difficile toxin B in monocytes (2000) (0)
Abstract 1484: Effects of UCN2 and its receptor CRHR2 in colorectal cancer growth and metastasis. (2013) (0)
Obesity in the Absence of High Fat Diet Enhances Tumor Development in AOM-Treated Mice (2011) (0)
P101 RNA-SEQ ANALYSIS OF MOUSE MODELS OF COLITIS IDENTIFIES NOVEL MRNA AND LNCRNA TARGETS ASSOCIATED WITH HUMAN INFLAMMATORY BOWEL DISEASE (2018) (0)
A novel role for the neuropeptide neurotensin in chronic colitis (2000) (0)
W1856 Neurokinin-1receptor (NK-1r) Deficiency is Associated With Reduced Weight Gain and Improved Glucose Metabolic Responses in Mice (2010) (0)
784 Impaired Resolution of Inflammation and Tissue Regeneration in Corticotropin Releasing Hormone (CRH)- Deficient Mice Following DSS-Colitis (2012) (0)
Comparative Efﬁcacies of Rifaximin and Vancomycin for Treatment of Clostridium difﬁcile -Associated Diarrhea and Prevention of Disease Recurrence in Hamsters (cid:1) (2008) (0)
MicroRNA targeting for the therapy of colitis-associated colon cancer. (2015) (0)
Tu1709 IBD-Associated Effects of Fat-Derived Mediators in the Regulation of Adiponectin Receptor 1 (AdipoR1) in Human Colonocytes (2014) (0)
P124 MICRORNA-24 IS OVEREXPRESSED IN ULCERATIVE COLITIS AND SIGNIFICANTLY AFFECTS INTESTINAL BARRIER FUNCTION (2019) (0)
Involvement of a NF-KB binding site in cytokine-mediated substance P (neurokinin-1) receptor upregulation in human monocytes (2000) (0)
CIostridizzm d$@ile Toxin B Disrupts the Barrier Function of T,, Monolayers (1992) (0)
Neurotensin in Regulation of Gastrointestinal Functions (2006) (0)
W2013 The Probiotic Bacillus Polyfermenticus Induces Angiogenesis via An Interleukin-8 (IL-8)/CXCR2-Dependent Mechanism (2009) (0)
Inflammatory Responses 2-Deficient Mice Have Reduced Intestinal Corticotropin-Releasing Hormone Receptor (2006) (0)
Human recombinant interleukin-11 (rhIL-11) protects hamsters and human colonic mucosa from C. difficile toxin A (TxA) & B (TxB) effects (1998) (0)
350 ALTERED GENE EXPRESSION IN THE COLON OF YOUNG MICE OVEREXPRESSING ALPHA-SYNUCLEIN (2020) (0)
The Trans-Golgi Network Protein Aftiphilin is Involved in Maintaining Colonic Epithelial Cell Integrity During Colonic Inflammation (2017) (0)
T1450 Glucocorticoids Mediate Spinal Microglia Activation and Visceral Hyperalgesia in a Rat Model of Chronic Stress (2008) (0)
Substance P (SP)-induced chloride secretion in human colon is mediated by intestinal nerves and mast cells and a tyrosine kinase-dependent pathway (1998) (0)
The Long Non-Coding RNA AFDN-AS1 Is Expressed in Colonic Epithelial Cells (2018) (0)
T1247 Toll-Like Receptor 5 Engagement with Flagellin Mediating the Innate Immunity Elicits Anti-Tumor Activity in Mouse Xenograft Model of Human Colon Cancer (2008) (0)
518 Corticotropin-Releasing Hormone Receptor 2 Mediates Epithelial Cell Proliferation, Apoptosis and Mucosal Repair Following Colitis (2015) (0)
Roles of endogenous and exogenous cathelicidin during colonic inflammation. (2011) (0)
Neurotensin (NT) stimulates IL-8 synthesis in non-malignant human colonocytes via NF-κB and MAP kinase-dependent pathways (2001) (0)
Chronic Stress Increases Body Fat Mass and Fat-Associated Metabolic Responses in Rats (2011) (0)
639 NEUROTENSIN (NT) SIGNALING-ASSOCIATED LONG NON-CODING RNA (LNCRNA) UCA1 IS A MEDIATOR OF HYPOXIC RESPONSE IN HUMAN COLONOCYTES (2020) (0)
891: ART24, A BACILLUS VELEZENSIS STRAIN, PROTECTS HUMAN COLONIC EPITHELIAL CELLS AGAINST CLOSTRIDIOIDES DIFFICILE TOXINMEDIATED APOPTOSIS (2022) (0)
Mesenteric Adipose Tissue Derived Stromal Cells from Crohn's Disease Patients Induce Lactoferrin-Dependent Protective Responses in Colonic Epithelial Cells and Mice with Colitis (2017) (0)
129 Identification of a LncRNA Signature in Ulcerative Colitis: IFNG-AS1 Is a CD4+ T-Cell LncRNA Associated With IBD SNP Loci (2016) (0)
Cathelicidin Modulates Clostridium difficile Toxin a-Mediated Enteritis (2011) (0)
Chapter 24 – Regulation of Gastrointestinal Mucin Production by Nerve–Mast Cell Interactions (2000) (0)
Mo1755 Myeloid Differentiation Factor 88 (MYD88) Is the Linchpin of Anti-Tumor Immunity Against Phosphatase and Tensin Homologue (PTEN)-Associated Intestinal Tumor Development and Metastasis (2015) (0)
Use Of Weighted Gene Coexpression Network Analysis To Identify Connectivity Between Gut And Brain Gene Expression (2022) (0)
Effects of adenosine (ADO) on human colonic mucosa in vitro (2000) (0)
Mo1104 – The Trans-Golgi Network Protein Aftiphilin Regulates Colonic Epithelial Cell Migration and is Crucial to Embryonic Development (2019) (0)
A long noncoding RNA signature for ulcerative colitis identiﬁes IFNG-AS1 as an enhancer of inﬂammation (2016) (0)
Decreased inflammation associated with corticotropin-releasing hormone (CRH) deficiency does not prevent weight loss during acute tnbs-induced colitis in mice (2003) (0)
271 Cathelicidin Inhibits Colitis Associated Colon Cancer Development by Inhibition of Epithelial-Mesenchymal Transition and Cancer Associated Fibroblasts (2014) (0)
934 Neurotensin-Induced Tumor Formation Is Regulated by Neurotensin Receptor 1 (NTR1)/MicroRNA-133a-Associated NTR1 Recycling Involving the Negative Regulator Zinc Finger E-Box-Binding Homeobox 1 (ZEB1) (2013) (0)
Colitis-Associated Adipose Tissue Responses to Corticotropin-Releasing Hormone Family of Neuropeptides (2011) (0)
P151 THE LONG NON-CODING RNA, IFNG-AS1/NEST, IS ASSOCIATED WITH IBD AND DRIVES A PRO-INFLAMMATORY SIGNALING CASCADE (2019) (0)
P-178 YI Expression of Long Non-Coding RNAs in Inflammatory Bowel Disease (2016) (0)
428 – Solute Carrier Family 26 Member 3 (SLC26A3) Restoration and Interleukin-1 Beta Inhibition Mediate the Therapeutic Effects of Macrophage Inflammatory Protein 1 Alpha (MIP-1Α/CCL3) Neutralizing Antibody in C. Difficile Infection in Mice (2019) (0)
Sa1598 - Dna Methylation Age Acceleration is Associated with Decreased Resilience in Irritable Bowel Syndrome (2018) (0)
Effects of adenosine receptor agonists on human colonic mucosa in vitro (2001) (0)
Expression of activated NF-κB, galanin, and galanin-1 receptors (G1R) in enteric nerves and colonocytes in murine and human colitis (2003) (0)
Su1610 – Dysregulation of Parkinson’s Disease Related Genes in Ulcerative Colitis and Murine Experimental Colitis (2019) (0)
S1651 Effects of Diet Induced Obesity in the Outcome of Experimental Colitis in C57BL/6 Mice (2009) (0)
95 Tl1A Deficiency, but Not Dr3 Deficiency, Ameliorated Murine Models of Chronic Colitis: Implications for Drug Development (2015) (0)
Neurotensin Stimulates Interleukin-8 Expression through Modulation of I (cid:1) B (cid:2) Phosphorylation and p65 Transcriptional Activity: Involvement of Protein Kinase C (cid:2) (2005) (0)
Epithelial Cells JAK-STAT Activation in Human Colonic Expression through 2 and Prostaglandin E Substance P Stimulates Cyclooxygenase-2 (2006) (0)
Mitochondrial generation of reactive oxygen species (ROS) is necessary for IL-8 release from colonocytes exposed to Clostridium difficile toxin A (2001) (0)
604 Identification of a NK-1R Antagonist as a Novel Therapeutic Approach in Colon Cancer by High Throughput Chemical Screening (2012) (0)
Tu1717 Role of Corticotropin-Releasing Hormone 2 in Mucosal Healing During Colitis (2014) (0)
1107 The Anti-Microbial Peptide Cathelicidin Modulates Clostridium difficile Toxin a - Mediated Inflammatory Responses in Mouse Intestine and Human Primary Monocytes (2012) (0)
S1753 Bacterial DNA Mediated Cathelicidin Secretion From Monocytes During Colonic Inflammation (2010) (0)
Tu1670 Inhibition of Corticotropin-Releasing Hormone Receptor 2 (CRHR2) Expression in Colorectal Cancer Correlates With Tumor Growth and EMT In Vitro and In Vivo, Poor Patient Survival and Increased Risk for Distant Metastases (2014) (0)
DDW 2017: Activities and Interests of the AGA Council (2017) (0)
Substance P induces angiogenic factor CCN1 expression via histone deacetylase activity in human colonic epithelial cells. (2011) (0)
epithelial cells to release eosinophil chemotactic activity Acetylcholine and substance P stimulate bronchial (2015) (0)
Autophagy is Involved in Optimal Expression of TL1A (TNFSF15) by Microbes in Primary Human Monocytes: P‐246 (2012) (0)
Mo1647 Neurotensin Signaling Activates the HIF-1/VEGF Pathway in Human Colonic Epithelial Cells (2012) (0)
813 LORATADINE AND GENISTEIN ARE EFFECTIVE REPURPOSED CANDIDATE DRUGS FOR TREATING CLOSTRIDIUM DIFFICILE INFECTION. (2021) (0)
Su1057 - Substance P Signaling Alters Microbiota in Experimental Colitis (2018) (0)
156 Phosphatase and Tensin Homolog PTEN Is an Essential Regulatory Factor in Toll-Like Receptor 5-Elicited Inflammatory Responses (2013) (0)
Mo1609 Obesity Drives Colon Tumor Development in AOM-Treated Mice (2012) (0)
1er congrès international sur la prévention des infections. Autor's reply (1990) (0)
Sa1731 Neurotensin-HIF-1α-MicroRNA 210 Axis Orchestrates Hypoxia, Colonic Inflammation and Intestinal Angiogenesis (2013) (0)
804: WEIGHTED GENE COEXPRESSION NETWORK ANALYSIS OF THE GUT-BRAIN AXIS TRANSCRIPTOME SUPPORTS THE PRESENCE OF INDEPENDENT PATHOPHYSIOLOGY IN THE GUT AND THE BRAIN OF A MOUSE MODEL OF PARKINSON DISEASE. (2022) (0)
Sa1807 Adiponectin Inflammatory and Metabolic Networks Regulate the Growth of Colon Tumor-Initiating Cells (2012) (0)
P123 THE TRANS-GOLGI NETWORK PROTEIN AFTIPHILIN MAINTAINS COLONIC EPITHELIAL PERMEABILITY AND MUCOSAL INTEGRITY THROUGH BETA CATENIN DURING INFLAMMATION (2018) (0)
Roles of Endogenous and Exogenous Cathelicidin During Colonic Inflammation (2011) (0)
Neuropeptides 2007 function, dysfunction and therapeutic options Santorini, Greece, 19–21 April, 2007 conference report (2008) (0)
Tu1902 High Throughput Screening Reveals a Novel Epigenetic MicroRNA-Inflammatory Network in Pediatric Ulcerative Colitis (2012) (0)
Antimicrobial peptides in intestinal inflammation, infection and cancer. (2013) (0)
779 A HNF4A MicroRNA-Inflammatory Circuit is Involved in the Pathogenesis of Ulcerative Colitis (UC) (2012) (0)
Su1771 Adipose Tissue Function in Ulcerative Colitis (UC): Mesenteric Preadipocytes From Patients With UC Exhibit Differential mRNA Expression Patterns and Alter Inflammatory Responses in Colonic Epithelial Cells and Mice With Colitis (2016) (0)
94 Probiotic Saccharomyces boulardii CNCM I-745 Inhibits Hypervirulent Clostridium difficile-Associated Cecal Tissue Damage and Pro-Inflammatory Cytokine Expression in Hamsters (2016) (0)
647 FECAL MICRORNAS ARE ASSOCIATED WITH TGF-BETA AND GABA SIGNALING IN C. DIFFICILE INFECTION (2020) (0)
782 β-Arrestin2 and Endothelin-Converting Enzyme-1 Control Substance P-Mediated Inflammatory Signaling and Colitis in Mice (2012) (0)
Tu1845 Mesenteric Preadipocytes From Crohn's Disease Patients Exhibit Differential mRNA Expression Patterns and Induce Protective Responses in Colonic Epithelial Cells and Mice With Colitis (2016) (0)
Tu1830 The Trans-Golgi Network Protein Aftiphilin Regulates Colonic Epithelial Cell Permeability Through Modulating Expression of Genes Involved in Cell Junctions in Colonic Epithelial Cells (2016) (0)
Mo1101 Beta-Arrestins and Endothelin-Converting Enzyme-1 Activity Mediate Neurotensin-Induced PRO-Inflammatory Signaling in Human Colonocytes (2012) (0)
In Vivo Constitutive Expression of an IBD Associated Gene TNFSF15 Causes Severe Inflammation and Induces Fibrostenotic Disease in 2 Murine Models of Chronic Colitis (2011) (0)
Aftiphilin regulation of myosin light chain kinase activity promotes actin dynamics and intestinal epithelial barrier function (2022) (0)
Clostridium difficile toxin a induces Z0-1 transiocation and paracellular flux via a protein kinase Cα-dependent pathway (2001) (0)
ventromedial medulla by neurokinin-1 receptors Differential modulation of neurons in the rostral (2015) (0)
Protective effects of human recombinant osteogenic protein-1 (bone morphogenic protein-7) (BMP-7) in Clostridium difficile toxin a (TXA)-mediated enteritis and TNBS-induced colitis (2000) (0)
Participation of reactive oxygen metabolites in Clostridium difficile toxin A-induced colitis. (1999) (0)
DDW 2016: Basic and Translational Activities and Interests of the AGA Council (2016) (0)
ADS024, a Bacillus velezensis strain, protects human colonic epithelial cells against C. difficile toxin-mediated apoptosis (2023) (0)
361 AFTIPHILIN-MEDIATED PARACELLULAR FLUX AND MYOSIN LIGHT CHAIN KINASE ACTIVATION REGULATES COLONIC EPITHELIAL CELL PERMEABILITY IN VITRO (2021) (0)
Neurotensin-HIF-1a-microRNA-210 Axis Orchestrates Hypoxia, Colonic Inflammation and Intestinal Angiogenesis (2013) (0)
360 SP/NK1R SIGNALING REGULATES POSTTRANSCRIPTIONAL MODIFICATION AND EXOSOMAL SORTING OF MIR-21 IN HUMAN COLONIC EPITHELIAL CELLS VIA ADORA2B RECEPTOR STIMULATION (2021) (0)
Heat shock protein, Hsp72, reduces C. difficile toxin A-mediated effects on colonic Caco2 cells by inhibiting toxin-induced mitochondrial damage (2001) (0)
Sa1753 Fidaxomicin and Opt-1118 Inhibit Clostridium difficile Toxin A - Mediated Inflammation in Mouse Ileum (2013) (0)
T1699 SRC-Family Tyrosine Kinase Lyn Regulates the Tyrosine Phosphorylation of Toll-Like Receptor 4 (2009) (0)
362 MIR-24-3P REGULATION OF CELL SURVIVAL MODULATES EPITHELIAL RECOVERY AFTER COLITIS (2021) (0)
Nuclear Factor-B in the Liver: Friend or Foe? (2007) (0)
Clostridium difficile toxin A and proinflammatory cytokines stimulate corticotropin-releasing hormone receptor 2 (CRHR2) expression in human colonic epithelial cells (2003) (0)
P151 THE LONG NON-CODING RNA, IFNG-AS1/NEST, IS ASSOCIATED WITH IBD AND DRIVES A PRO-INFLAMMATORY SIGNALING CASCADE. (2019) (0)
573 - Gene Expression Network Analysis of the Gut-Brain Axis Supports an Association Between Alpha-Synuclein and Markers of Enteric Glial Cells (2018) (0)
Corrigendum: Serum and Colonic Mucosal Immune Markers in Irritable Bowel Syndrome (2012) (0)
Immune Regulatory Effect of Phosphatase and Tensin Homologue (PTEN) in the Gut is Associated with Extraintestinal Inflammation (2017) (0)
Anti‐fibrogenic Roles of Cathelicidin in Chronic Colitis Associated Colonic Fibrosis: P‐233 YI (2012) (0)
Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis (2018) (0)
W1584 Corticotropin Releasing Hormone Family Peptides Regulate Intestinal Angiogenesis (2009) (0)
T2072 Colonic Mucosal Inflammation is Unlikely to Play a Primary Role in Irritable Bowel Syndrome (2010) (0)
Antibiotic-Associated Diarrhea (2004) (0)
401 Stress-Related Biomarkers and Symptoms Are Predictive of Irritable Bowel Syndrome (IBS) (2009) (0)
Clostridium difficile toxin A-induced enterotoxicity is dependent on a functional enteroglial cell network in adult transgenic mice (2003) (0)
Su1182 Intestinal Cathelicidin Levels Predict Prognosis of Ulcerative Colitis Patients (2013) (0)

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Boston University
University of California, Los Angeles
Massachusetts General Hospital

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