Charles C. Richardson

Charles C. Richardson's AcademicInfluence.com Rankings

Biology

#2497

World Rank

#3951

Historical Rank

#1111

USA Rank

Biochemistry

#263

World Rank

#327

Historical Rank

#118

USA Rank

biology Degrees

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Biology

Charles C. Richardson's Degrees

Bachelors Biochemistry University of California, Berkeley
PhD Biochemistry Stanford University

Why Is Charles C. Richardson Influential?

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According to Wikipedia, Charles Clifton Richardson is an American biochemist and professor at Harvard University. Richardson received his undergraduate education at Duke University, where he majored in medicine. He received his M.D. at Duke Medical School in 1960. Richardson works as a professor at Harvard Medical School, and he served as editor/associate editor of the Annual Review of Biochemistry from 1972 to 2003. Richardson received the American Chemical Society Award in Biological Chemistry in 1968, as well as numerous other accolades.

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Charles C. Richardson's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. (1985) (2914)
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. (1987) (1786)
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution (1998) (1118)
Phosphorylation of nucleic acid by an enzyme from T4 bacteriophage-infected Escherichia coli. (1965) (373)
Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7. (1987) (359)
A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides. (1995) (338)
ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI. (1964) (330)
Single-Molecule Kinetics of λ Exonuclease Reveal Base Dependence and Dynamic Disorder (2003) (296)
DNA primase acts as a molecular brake in DNA replication (2006) (285)
Crystal Structure of the Helicase Domain from the Replicative Helicase-Primase of Bacteriophage T7 (1999) (284)
A DEOXYRIBONUCLEIC ACID PHOSPHATASE-EXONUCLEASE FROM ESCHERICHIA COLI. II. CHARACTERIZATION OF THE EXONUCLEASE ACTIVITY. (1964) (262)
Effect of manganese ions on the incorporation of dideoxynucleotides by bacteriophage T7 DNA polymerase and Escherichia coli DNA polymerase I. (1989) (258)
DNA primases. (2001) (252)
Replication and repair of DNA in cells of Escherichia coli treated with toluene. (1970) (252)
Enzymatic breakage and joining of deoxyribonucleic acid. VI. Further purification and properties of polynucleotide ligase from Escherichia coli infected with bacteriophage T4. (1968) (250)
Enzymatic breakage and joining of deoxyribonucleic acid. V. End group labeling and analysis of deoxyribonucleic acid containing single straned breaks. (1968) (228)
Selective inactivation of the exonuclease activity of bacteriophage T7 DNA polymerase by in vitro mutagenesis. (1989) (213)
Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage. (1967) (212)
Escherichia coli thioredoxin: a subunit of bacteriophage T7 DNA polymerase. (1976) (203)
A DEOXYRIBONUCLEIC ACID PHOSPHATASE-EXONUCLEASE FROM ESCHERICHIA COLI. I. PURIFICATION OF THE ENZYME AND CHARACTERIZATION OF THE PHOSPHATASE ACTIVITY. (1964) (199)
Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis, and template switching. (1989) (198)
Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates. (1987) (190)
Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. (2004) (179)
Motors, switches, and contacts in the replisome. (2009) (173)
Genomewide screens for Escherichia coli genes affecting growth of T7 bacteriophage (2006) (166)
Coordinated leading and lagging strand DNA synthesis on a minicircular template. (1998) (158)
The gene 4 protein of bacteriophage T7. Characterization of helicase activity. (1983) (154)
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis (2009) (148)
The 5'-terminal nucleotides of T7 bacteriophage deoxyribonucleic acid. (1966) (147)
Enzymatic breakage and joining of deoxyribonucleic acid. 8. Hybrids of ribo- and deoxyribonucleotide homopolymers as substrates for polynucleotide ligase of bacteriophage T4. (1971) (139)
Interaction of mutant thioredoxins of Escherichia coli with the gene 5 protein of phage T7. The redox capacity of thioredoxin is not required for stimulation of DNA polymerase activity. (1986) (139)
Interactions of the RNA polymerase of bacteriophage T7 with its promoter during binding and initiation of transcription. (1986) (133)
ENZYMIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. 18. THE REPAIR OF PARTIALLY SINGLE-STRANDED DNA TEMPLATES BY DNA POLYMERASE. (1964) (129)
Genetic recombination and complementation between bacteriophage T7 and cloned fragments of T7 DNA. (1978) (129)
Exonuclease VII of Escherichia coli. Mechanism of action. (1974) (127)
Bacteriophage T7: Minimal requirements for the replication of a duplex DNA molecule (1983) (124)
Impact of macromolecular crowding on DNA replication (2012) (123)
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. (2003) (118)
THE DEOXYRIBONUCLEASES OF ESCHERICHIA COLI. IV. AN EXONUCLEASE ACTIVITY PRESENT IN PURIFIED PREPARATIONS OF DEOXYRIBONUCLEIC ACID POLYMERASE. (1964) (117)
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange (2011) (117)
Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. (2007) (116)
DNA-dependent nucleoside 5'-triphosphatase activity of the gene 4 protein of bacteriophage T7. (1983) (115)
Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptase. (1990) (115)
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Effect of pyrophosphorolysis and metal ions. (1990) (114)
Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7 (1994) (110)
Terminal repetition in permuted T2 bacteriophage DNA molecules. (1967) (108)
Genomic analysis of bacteriophages SP6 and K1-5, an estranged subgroup of the T7 supergroup. (2004) (105)
A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor. (2005) (104)
Template recognition sequence for RNA primer synthesis by gene 4 protein of bacteriophage T7. (1981) (104)
Enzymes in DNA metabolism. (1969) (104)
DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicase. (2006) (103)
Deoxyribonucleic acid polymerase of bacteriophage T7. (1971) (96)
Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. (2003) (96)
DNA sequence analysis with a modified bacteriophage T 7 DNA polymerase ( DNA polymerase I / reverse transcriptase / chain-terminating inhibitors / 2 '-deoxyinosine 5 '-triphosphate / processivity ) (94)
The thioredoxin binding domain of bacteriophage T7 DNA polymerase confers processivity on Escherichia coli DNA polymerase I. (1997) (93)
A 7-kDa region of the bacteriophage T7 gene 4 protein is required for primase but not for helicase activity. (1988) (92)
The Linker Region between the Helicase and Primase Domains of the Bacteriophage T7 Gene 4 Protein Is Critical for Hexamer Formation* (1999) (91)
Exonuclease VII of Escherichia coli. Purification and properties. (1974) (90)
The Acidic Carboxyl Terminus of the Bacteriophage T7 Gene 4 Helicase/Primase Interacts with T7 DNA Polymerase* (1997) (89)
Structure of the gene 2.5 protein, a single-stranded DNA binding protein encoded by bacteriophage T7 (2001) (89)
Isolation and partial characterization of a mutant of Escherichia coli deficient in DNA polymerase II. (1972) (83)
The structural gene for a T7 endonuclease essential for phage DNA synthesis. (1970) (81)
A new DNA polymerase activity of Escherichia coli. I. Purification and properties of the activity present in E. coli polA1. (1970) (81)
Requirements for primer synthesis by bacteriophage T7 63-kDa gene 4 protein. Roles of template sequence and T7 56-kDa gene 4 protein. (1991) (80)
Processing of mRNA by ribonuclease III regulates expression of gene 1.2 of bacteriophage T7 (1981) (80)
ENZYMIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XVII. SOME UNUSUAL PHYSICAL PROPERTIES OF THE PRODUCT PRIMED BY NATIVE DNA TEMPLATES. (1964) (79)
Purification and characterization of the bacteriophage T7 gene 2.5 protein. A single-stranded DNA-binding protein. (1992) (78)
Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits. (1975) (76)
An endonuclease induced after infection of Escherichia coli with bacteriophage T7. I. Purification and properties of the enzyme. (1970) (76)
Gene 5.5 protein of bacteriophage T7 inhibits the nucleoid protein H-NS of Escherichia coli. (1993) (75)
Enzymatic properties of a proteolytically nicked RNA polymerase of bacteriophage T7. (1987) (74)
Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. (1975) (74)
A mutant of bacteriophage T7 deficient in polynucleotide ligase. (1971) (73)
A Domain of the Gene 4 Helicase/Primase of Bacteriophage T7 Required for the Formation of an Active Hexamer (*) (1995) (72)
Interactions of gene 2.5 protein and DNA polymerase of bacteriophage T7. (1992) (72)
Characterization of strand displacement synthesis catalyzed by bacteriophage T7 DNA polymerase. (1983) (71)
A preformed, topologically stable replication fork. Characterization of leading strand DNA synthesis catalyzed by T7 DNA polymerase and T7 gene 4 protein. (1983) (71)
Exonuclease VII of Escherichia coli. (1975) (68)
The Carboxyl-terminal Domain of Bacteriophage T7 Single-stranded DNA-binding Protein Modulates DNA Binding and Interaction with T7 DNA Polymerase* (2003) (68)
Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins. (2002) (67)
Choreography of bacteriophage T7 DNA replication. (2011) (67)
Strand displacement during deoxyribonucleic acid synthesis at single strand breaks. (1971) (67)
Analysis of the interruptions in bacteriophage T5 DNA. (1970) (65)
Single-molecule studies of polymerase dynamics and stoichiometry at the bacteriophage T7 replication machinery (2014) (65)
An N-terminal fragment of the gene 4 helicase/primase of bacteriophage T7 retains primase activity in the absence of helicase activity. (1998) (65)
Acidic carboxyl-terminal domain of gene 2.5 protein of bacteriophage T7 is essential for protein-protein interactions. (1994) (65)
Oligomeric states of bacteriophage T7 gene 4 primase/helicase. (2006) (64)
Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis (2011) (64)
Requirement for a zinc motif for template recognition by the bacteriophage T7 primase. (1994) (64)
Replication of duplex DNA by bacteriophage T7 DNA polymerase and gene 4 protein is accompanied by hydrolysis of nucleoside 5'-triphosphates. (1977) (63)
The effect of the T7 and Escherichia coli DNA-binding proteins at the replication fork of bacteriophage T7. (1988) (63)
Exchange of DNA polymerases at the replication fork of bacteriophage T7 (2007) (63)
Formation of a DNA Loop at the Replication Fork Generated by Bacteriophage T7 Replication Proteins* (1998) (63)
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. (2004) (62)
Single‐stranded DNA binding protein and DNA helicase of bacteriophage T7 mediate homologous DNA strand exchange. (1996) (61)
Enzymatic breakage and joining of deoxyribonucleic acid. II. The structural gene for polynucleotide ligase in bacteriophage T4. (1967) (60)
Studies on the Replication of DNA by DNA Polymerases (1963) (59)
Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA (2010) (59)
Bacteriophage T7 gene 2.5 protein: an essential protein for DNA replication. (1993) (59)
Simultaneous Real-Time Imaging of Leading and Lagging Strand Synthesis Reveals the Coordination Dynamics of Single Replisomes. (2016) (58)
Two forms of the DNA polymerase of bacteriophage T7. (1983) (58)
Escherichia coli mutants deficient in exonuclease VII (1977) (57)
Bacteriophage T7 deoxyribonucleic acid replication in vitro. V. Synthesis of intact chromosomes of bacteriophage T7. (1976) (56)
Molecular mechanisms in DNA replication and recombination (1990) (56)
Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin (2010) (56)
The Cys4 zinc finger of bacteriophage T7 primase in sequence-specific single-stranded DNA recognition. (1999) (55)
The nucleotide binding site of the helicase/primase of bacteriophage T7. Interaction of mutant and wild-type proteins. (1993) (55)
Bacteriophage T7 deoxyribonucleic acid replication in vitro. Requirements for deoxyribonucleic acid synthesis and characterization of the product. (1974) (55)
Deoxyribonucleic acid polymerase III of Escherichia coli. Characterization of associated exonuclease activities. (1975) (55)
The Role of the Zinc Motif in Sequence Recognition by DNA Primases* (1996) (55)
The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling. (2004) (54)
Enhanced Binding of Azidothymidine-resistant Human Immunodeficiency Virus 1 Reverse Transcriptase to the 3′-Azido-3′-deoxythymidine 5′-Monophosphate-terminated Primer* (1998) (53)
Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface (2008) (53)
The 5'-terminal dinucleotides of the separated strands of T7 bacteriophage deoxyribonucleic acid. (1967) (53)
Ezymatic breakage and joining of deoxyribonucleic acid. VII. Properties of the enzyme-adenylate intermediate in the polynucleotide ligase reaction. (1968) (52)
Interaction of Bacteriophage T7 Gene 4 Primase with Its Template Recognition Site* (1999) (52)
Deoxyribonucleic acid polymerase of bacteriophage T7. Characterization of the exonuclease activities of the gene 5 protein and the reconstituted polymerase. (1979) (51)
Characterization of the helicase and primase activities of the 63-kDa component of the bacteriophage T7 gene 4 protein. (1989) (51)
Single-Molecule Measurement of Protein Folding Kinetics (50)
Leading and lagging strand synthesis at the replication fork of bacteriophage T7. Distinct properties of T7 gene 4 protein as a helicase and primase. (1988) (49)
Essential Residues in the C Terminus of the Bacteriophage T7 Gene 2.5 Single-stranded DNA-binding Protein* (2006) (49)
Enzymatic removal and replacement of nucleotides at single strand breaks in deoxyribonucleic acid. (1971) (49)
Selective oxidation of the exonuclease domain of bacteriophage T7 DNA polymerase. (1987) (48)
Interactions of the DNA polymerase and gene 4 protein of bacteriophage T7. Protein-protein and protein-DNA interactions involved in RNA-primed DNA synthesis. (1986) (48)
Role of the Bacteriophage T7 and T4 Single-stranded DNA-binding Proteins in the Formation of Joint Molecules and DNA Helicase-catalyzed Polar Branch Migration* (1997) (48)
Deoxyribonucleic acid polymerase III of Escherichia coli. Purification and properties. (1975) (47)
Single Molecule Force Spectroscopy of Salt-dependent Bacteriophage T7 Gene 2.5 Protein Binding to Single-stranded DNA* (2006) (46)
Nucleotide-dependent binding of the gene 4 protein of bacteriophage T7 to single-stranded DNA. (1985) (45)
Interactions of Escherichia coli Thioredoxin, the Processivity Factor, with Bacteriophage T7 DNA Polymerase and Helicase* (2008) (45)
Characterization of the ribonucleic acid primers and the deoxyribonucleic acid product synthesized by the DNA polymerase and gene 4 protein of bacteriophage T7. (1979) (44)
Roles of bacteriophage T7 gene 4 proteins in providing primase and helicase functions in vivo. (1992) (44)
Enzymatic breakage and joining of deoxyribonucleic acid. IX. Synthesis and properties of the deoxyribonucleic acid adenylate in the phage T4 ligase reaction. (1971) (43)
A unique deoxyguanosine triphosphatase is responsible for the optA1 phenotype of Escherichia coli. (1988) (43)
C-terminal Phenylalanine of Bacteriophage T7 Single-stranded DNA-binding Protein Is Essential for Strand Displacement Synthesis by T7 DNA Polymerase at a Nick in DNA* (2009) (42)
Interactions of a proteolytically nicked RNA polymerase of bacteriophage T7 with its promoter. (1987) (42)
Purification of the 56-kDa component of the bacteriophage T7 primase/helicase and characterization of its nucleoside 5'-triphosphatase activity. (1988) (42)
Escherichia coli dGTP triphosphohydrolase is inhibited by gene 1.2 protein of bacteriophage T7. (1988) (42)
Genetic analysis of gene 1.2 of bacteriophage T7: isolation of a mutant of Escherichia coli unable to support the growth of T7 gene 1.2 mutants (1981) (42)
Nucleotide sequence of the primary origin of bacteriophage T7 DNA replication: relationship to adjacent genes and regulatory elements. (1980) (41)
Molecular crowding enhanced ATPase activity of the RNA helicase eIF4A correlates with compaction of its quaternary structure and association with eIF4G. (2013) (41)
Essential Lysine Residues in the RNA Polymerase Domain of the Gene 4 Primase-Helicase of Bacteriophage T7* (2001) (41)
A new DNA polymerase acitvity of Escherichia coli. II. Properties of the enzyme purified from wild-type E. coli and DNA-ts mutants. (1970) (41)
Physical mapping of primary and secondary origins of bacteriophage T7 DNA replication. (1980) (40)
The C-terminal Residues of Bacteriophage T7 Gene 4 Helicase-Primase Coordinate Helicase and DNA Polymerase Activities* (2006) (39)
Replication of bacteriophage T7 DNA by purified proteins. (1979) (39)
Initiation of DNA replication at the primary origin of bacteriophage T7 by purified proteins. Site and direction of initial DNA synthesis. (1985) (38)
Gene 4 DNA Primase of Bacteriophage T7 Mediates the Annealing and Extension of Ribo-oligonucleotides at Primase Recognition Sites* (1997) (38)
Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7 (2002) (37)
Interaction of Ribonucleoside Triphosphates with the Gene 4 Primase of Bacteriophage T7* (1999) (37)
Role of the Acidic Carboxyl-terminal Domain of the Single-stranded DNA-binding Protein of Bacteriophage T7 in Specific Protein-Protein Interactions* (1998) (37)
A Complex of the Bacteriophage T7 Primase-Helicase and DNA Polymerase Directs Primer Utilization* (2001) (37)
Deoxyribonucleic acid polymerase of bacteriophage T7. Purification and properties of the phage-encoded subunit, the gene 5 protein. (1979) (37)
An Interaction between DNA Polymerase and Helicase Is Essential for the High Processivity of the Bacteriophage T7 Replisome* (2012) (36)
A Covalent Linkage between the Gene 5 DNA Polymerase of Bacteriophage T7 and Escherichia coli Thioredoxin, the Processivity Factor (2003) (36)
Evidence for distinct primase and helicase domains in the 63-kDa gene 4 protein of bacteriophage T7. Characterization of nucleotide binding site mutant. (1993) (35)
Effect of Single-stranded DNA-binding Proteins on the Helicase and Primase Activities of the Bacteriophage T7 Gene 4 Protein* (2004) (33)
Influence of glucosylation of deoxyribonucleic acid on hydrolysis by deoxyribonucleases of Escherichia coli. (1966) (33)
Roles of the helicase and primase domain of the gene 4 protein of bacteriophage T7 in accessing the primase recognition site (1998) (32)
Template Recognition and Ribonucleotide Specificity of the DNA Primase of Bacteriophage T7* (1997) (32)
16 Bacteriophage T4 Polynucleotide Kinase (1981) (32)
The Linker Region between the Helicase and Primase Domains of the Gene 4 Protein of Bacteriophage T7 (2004) (32)
Two Modes of Interaction of the Single-stranded DNA-binding Protein of Bacteriophage T7 with the DNA Polymerase-Thioredoxin Complex* (2010) (32)
A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. 1985. (1992) (32)
Bacteriophage T7 deoxyribonucleic acid replication in vitro. Purification and properties of the gene 4 protein of bacteriophage T7. (1975) (31)
The DNA Binding Domain of the Gene 2.5 Single-stranded DNA-binding Protein of Bacteriophage T7* (2003) (31)
Enzymatic breadage and joining of deoxyribonucleic acid. 3. An enzyme-adenylate intermediate in the polynucleotide ligase reaction. (1967) (31)
Initiation of DNA replication at the primary origin of bacteriophage T7 by purified proteins: requirement for T7 RNA polymerase. (1981) (31)
Primer initiation and extension by T7 DNA primase (2006) (31)
Gene 2 protein of bacteriophage T7: purification and requirement for packaging of T7 DNA in vitro. (1979) (31)
The RNA Polymerase of Marine Cyanophage Syn5* (2012) (30)
A unique loop in the DNA-binding crevice of bacteriophage T7 DNA polymerase influences primer utilization. (2000) (30)
Processing of concatemers of bacteriophage T7 DNA in vitro. (1987) (30)
Amino Acid Residues Critical for the Interaction between Bacteriophage T7 DNA Polymerase and Escherichia coli Thioredoxin* (1996) (29)
Structure and regulation of the gene for dGTP triphosphohydrolase from Escherichia coli (1990) (29)
Bypass of a Nick by the Replisome of Bacteriophage T7* (2011) (29)
Initiation of DNA replication at the primary origin of bacteriophage T7 by purified proteins. Initiation of bidirectional synthesis. (1985) (28)
Gene 4 protein of bacteriophage T7. Purification physical properties, and stimulation of T7 DNA polymerase during the elongation of polynucleotide chains. (1978) (28)
Essential Amino Acid Residues in the Single-stranded DNA-binding Protein of Bacteriophage T7 (2002) (28)
A Single-stranded DNA-binding Protein of Bacteriophage T7 Defective in DNA Annealing* (2003) (26)
Syn5 RNA polymerase synthesizes precise run-off RNA products (2013) (26)
Direct role for the RNA polymerase domain of T7 primase in primer delivery (2010) (26)
The Replication System of Bacteriophage T7. (2016) (26)
The Highly Processive DNA Polymerase of Bacteriophage T5 (2004) (25)
Acidic Residues in the Nucleotide-binding Site of the Bacteriophage T7 DNA Primase* (2005) (25)
Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein. (2019) (24)
An endonuclease induced after infection of Escherichia coli with bacteriophage T7. II. Specificity of the enzyme toward single- and double-stranded deoxyribonucleic acid. (1970) (24)
Genetic analysis of the interaction between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin. (1992) (23)
Coupling dTTP Hydrolysis with DNA Unwinding by the DNA Helicase of Bacteriophage T7* (2011) (23)
Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7 (2010) (23)
Bacteriophage T7 DNA replication. Synthesis of lagging strands in a reconstituted system using purified proteins. (1983) (23)
New Details about Bacteriophage T7-Host Interactions: Researchers are showing renewed interest in learning how phages interact with bacterial hosts, adapting to and overcoming their defenses (2010) (22)
Studies on the joining of DNA by polynucleotide ligase of phage T4. (1968) (22)
Gene 4 helicase of bacteriophage T7 mediates strand transfer through pyrimidine dimers, mismatches, and nonhomologous regions. (1997) (22)
Synthesis of 2′-Fluoro RNA by Syn5 RNA polymerase (2015) (22)
Requirements for synthesis of ribonucleic acid primers during lagging strand synthesis by the DNA polymerase and gene 4 protein of bacteriophage T7. (1979) (22)
Amino Acid Changes in a Unique Sequence of Bacteriophage T7 DNA Polymerase Alter the Processivity of Nucleotide Polymerization* (1997) (22)
Gene 4 protein of bacteriophage T7. Characterization of the product synthesized by the T7 DNA polymerase and gene 4 protein in the absence of ribonucleoside 5'-triphosphates. (1978) (21)
Thioredoxin, the Processivity Factor, Sequesters an Exposed Cysteine in the Thumb Domain of Bacteriophage T7 DNA Polymerase* (2012) (21)
Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis (2017) (21)
The gene 1.2 protein of bacteriophage T7 interacts with the Escherichia coli dGTP triphosphohydrolase to form a GTP-binding protein. (1990) (21)
Gene 1.2 protein of bacteriophage T7. Effect on deoxyribonucleotide pools. (1987) (21)
The deoxyribonuclease induced after infection of Escherichia coli by bacteriophage T5. I. Characterization of the enzyme as a 5'-exonuclease. (1971) (21)
Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication (2012) (20)
Binding of RNA template to a complex of HIV-1 reverse transcriptase/primer/template. (1997) (20)
Modification and restriction of T-even bacteriophages. In vitro degradation of deoxyribonucleic acid containing 5-hydroxymethylctosine. (1976) (20)
Bacteriophage T7 deoxyribonucleic acid replication in vitro VI. Synthesis of biologically active T7 DNA. (1976) (20)
A bacteriophage T 7 RNA polymerase / promoter system for controlled exclusive expression of specific genes ( T 7 DNA polymerase / T 7 gene 5 protein / proteolysis / 13-lactamase / rifampicin ) (2003) (20)
Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk (2007) (18)
Initiation of DNA replication at cloned origins of bacteriophage T7. (1988) (18)
Role of the C-terminal Residue of the DNA Polymerase of Bacteriophage T7* (2001) (18)
Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers (2017) (18)
Dissection of RNA-primed DNA synthesis catalyzed by gene 4 protein and DNA polymerase of bacteriophage T7. Coupling of RNA primer and DNA synthesis. (1986) (18)
Binding Affinities among DNA Helicase-Primase, DNA Polymerase, and Replication Intermediates in the Replisome of Bacteriophage T7* (2015) (17)
Identification of DNA primase inhibitors via a combined fragment-based and virtual screening (2016) (17)
The Motif D Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Critical for Nucleoside 5′-Triphosphate Selectivity* (1999) (17)
DNA recognition by the DNA primase of bacteriophage T7: a structure-function study of the zinc-binding domain. (2009) (17)
Gene 18 protein of bacteriophage T7. Overproduction, purification, and characterization. (1987) (17)
An in Trans Interaction at the Interface of the Helicase and Primase Domains of the Hexameric Gene 4 Protein of Bacteriophage T7 Modulates Their Activities* (2009) (17)
The deoxyribonuclease induced after infection of Escherichia coli by bacteriophage T5. II. Role of the enzyme in replication of the pahge deoxyribonucleic acid. (1971) (17)
Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome (2016) (17)
Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication* (2012) (16)
Mechanisms for the initiation of bacteriophage T7 DNA replication. (1983) (16)
Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7 (2008) (16)
Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine (2008) (16)
Characterization of a novel DNA primase from the Salmonella typhimurium bacteriophage SP6. (2000) (15)
DNA binding properties of the deoxyguanosine triphosphate triphosphohydrolase of Escherichia coli. (1993) (15)
A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7 (2010) (14)
Promiscuous Usage of Nucleotides by the DNA Helicase of Bacteriophage T7 (2009) (14)
The Enzymatic Phosphorylation of Nucleic Acids and Its Application to End-Group Analysis (1966) (14)
Residues in the central β-hairpin of the DNA helicase of bacteriophage T7 are important in DNA unwinding (2010) (14)
Synthesis of bacteriophage lambda DNA in vitro: requirement for O and P gene products. (1974) (13)
In vivo analysis of the initiation of bacteriophage T7 DNA replication. (1990) (13)
Analysis of host range restriction in Escherichia coli treated with toluene. (1971) (12)
Structural and Functional Organization of the DNA Polymerase of Bacteriophage T7* (1996) (12)
Molecular interactions in the priming complex of bacteriophage T7 (2012) (12)
Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay (2010) (12)
A functional chimeric DNA primase: the Cys4 zinc-binding domain of bacteriophage T3 primase fused to the helicase of bacteriophage T7. (1994) (12)
It seems like only yesterday. (2015) (12)
Mapping of a Mutation, polB100, Affecting Deoxyribonucleic Acid Polymerase II in Escherichia coli K-12 (1974) (12)
Isolation of a specialized transducing bacteriophage lambda carrying the polC locus of Escherichia coli. (1974) (11)
A Unique Region in Bacteriophage T7 DNA Polymerase Important for Exonucleolytic Hydrolysis of DNA* (2004) (11)
Flap Endonuclease Activity of Gene 6 Exonuclease of Bacteriophage T7* (2014) (10)
Essential protein interactions within the replisome regulate DNA replication (2011) (10)
The Roles of Tryptophans in Primer Synthesis by the DNA Primase of Bacteriophage T7* (2012) (9)
Pyrovanadolysis, a Pyrophosphorolysis-like Reaction Mediated by Pyrovanadate, Mn2+, and DNA Polymerase of Bacteriophage T7* (2011) (9)
Cloning of the T7 genome in Escherichia coli: use of recombination between cloned sequences and bacteriophage T7 to identify genes involved in recombination and a clone containing the origin of T7 DNA replication. (1979) (9)
Molecular Basis for Recognition of Nucleoside Triphosphate by Gene 4 Helicase of Bacteriophage T7* (2010) (9)
Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C‐terminal phenylalanine (2009) (9)
Zinc-binding Domain of the Bacteriophage T7 DNA Primase Modulates Binding to the DNA Template* (2012) (9)
The Glutamate Switch of Bacteriophage T7 DNA Helicase (2011) (8)
Enzymatic breakage and joining of deoxyribonucleic acid. IV. DNA synthesis in E. coli infected with ligase-negative mutants of phage T4. (1968) (8)
Effects of base analog substitutions in the noncoding dC of the 3'-d(CTG)-5' template recognition site of the bacteriophage T7 primase. (1995) (8)
Purification and characterization of the gene 1.2 protein of bacteriophage T7. (1987) (8)
Characterization of a Nucleotide Kinase Encoded by Bacteriophage T7* (2012) (7)
Replication of Bacteriophage T7 DNA (1983) (7)
Enzymatic mechanisms of DNA replication in Escherichia coli. (1972) (7)
Gene 19 of bacteriophage T7. Overexpression, purification, and characterization of its product. (1988) (7)
Essential Amino Acid Residues in the Single-stranded Dna-binding Protein of Bacteriophage T7. Identification of the Dimer Interface (2002) (7)
Binding of Mn-deoxyribonucleoside triphosphates to the active site of the DNA polymerase of bacteriophage T7 (2011) (7)
Flap endonuclease of bacteriophage T7 (2014) (6)
Genetic Requirements for Sensitivity of Bacteriophage T7 to Dideoxythymidine (2014) (6)
Chemical and enzymatic studies of deoxyribonucleic acid covalently linked to Ficoll. (1972) (6)
Rescue of Bacteriophage T7 DNA Polymerase of Low Processivity by Suppressor Mutations Affecting Gene 3 Endonuclease (2009) (6)
Studies on the Replication of DNA by Escherichia coli Polymerase (1963) (6)
A Mutation in the Gene-encoding Bacteriophage T7 DNA Polymerase That Renders the Phage Temperature-sensitive* (2001) (5)
Genetic recombination and complementation between bacteriophage T 7 and cloned fragments of T 7 DNA ( physical mapping / Escherichia coli / pMB 9 plasmid ) (5)
End-group labeling of nucleic acids by enzymatic phosphorylation. (1966) (5)
T7 DNA POLYMERASE COMPLEXED TO DNA PRIMER/TEMPLATE,A NUCLEOSIDE TRIPHOSPHATE, AND ITS PROCESSIVITY FACTOR THIOREDOXIN (1998) (5)
University of Groningen Single-Molecule Kinetics of λ Exonuclease Reveal Base Dependence and Dynamic Disorder Oijen, (2003) (4)
Nucleases as reagents in the study of nucleic acid structure. (1965) (3)
Priming of deoxyribonucleic acid synthesis on phage fd and phiX174 templates by oligoribonucleotides contaminating nucleoside 5'-triphosphates. (1977) (3)
Genetic mapping of trxA, a gene affecting thioredoxin in Escherichia coli K12 (1977) (3)
The Nucleotide Binding Site of the Helicase / Primase of Bacteriophage T 7 (2001) (2)
Crystal Structure of gp2.5, a Single-Stranded DNA Binding Protein Encoded by Bacteriophage T7 (2001) (2)
DNA Polymerases of Escherichia coli (1973) (2)
Interactions of the RNA polymerase of bacteriophage T 7 with its promoter during binding and initiation of transcription ( " footprinting " / methidiumpropyl-EDTA / mRNA ) (2003) (2)
Hydrophobic Residue in Escherichia coli Thioredoxin Critical for the Processivity of T7 DNA Polymerase. (2018) (2)
INITIATION OF BACTERIOPHAGE T7 DNA REPLICATION (1981) (2)
Peptide ligands specific to the oxidized form of Escherichia coli thioredoxin. (2008) (2)
Kinetics of Lagging-strand DNA Synthesis In Vitro by the Bacteriophage T7 Replication Proteins. (2017) (2)
Possible roles in RNA primer removal, recombination and host DNA breakdown (2014) (2)
Role of the C-terminal Residue of the DNA Polymerase of Bacteriophage T 7 * (2001) (1)
Catalytically inactive T7 DNA polymerase imposes a lethal replication roadblock (2020) (1)
Bacteriophage T7 gene 4 protein: A hexameric DNA helicase (2003) (1)
Characterization and modification of phage T7 DNA polymerase for use in DNA sequencing. Final report, June 1, 1988--January 31, 1996 (1996) (1)
Initiation of DNA Replication at the Primary Origin of Bacteriophage T 7 by Purified Proteins (1)
Gene 2 protein of bacteriophage T 7 : Purification and requirement for packaging of T 7 DNA in vitro * ( DNA synthesis / DNA maturation / RNA polymerase / rifampicin ) (0)
Linear Diffusion of T7 DNA Polymerase: Thioredoxin is Required to Maintain Close Contact with DNA (2009) (0)
Mechanism of DNA binding and sequence recognition by T7 DNA primase (2006) (0)
Single-molecule Observations of Replisome Structure and Function (2009) (0)
Single Molecule Force Spectroscopy of Salt-dependent Bacteriophage T7 Gene 2.5 Protein Binding to (2006) (0)
Interaction of Escherichia coli Thioredoxin with the Bacteriophage T7 Polymerase, Helicase/Primase at the Replication Fork (2007) (0)
Isolation and Partial Characterization of a Mutant of Escherichia coli Deficient in DNA Polymerase II ( mutagenesis / polAl mutants / polBl mutants / DNA replication (0)
Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C‐terminal phenylalanine (2009) (0)
Residues of Escherichia coli thioredoxin critical for interaction with phage T7 DNA polymerase to increase processivity (2017) (0)
Pyrovanadolysis, a Pyrophosphorolysis-like Reaction Mediated by Pyrovanadate, Mn 2 , and DNA Polymerase of (2011) (0)
Recycling of DNA Polymerases at the Replication Fork of Bacteriophage T7 (2007) (0)
DNA polymerase with altered nucleotide binding site (1994) (0)
T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene on the template, crystallized with dideoxy-ATP as the incoming nucleotide. (2004) (0)
Synthesis ofBacteriophage LambdaDNA InVitro: Requirement for0 andP GeneProducts (1974) (0)
Simultaneous Imaging of Leading- and Lagging-Strand Synthesis Reveals Distinct Operational Modes of Single Replication Machines (2014) (0)
Binding of the DNA primase of bacteriophage T7 to its recognition sequence in DNA is modulated by the zinc‐binding domain (2010) (0)
Crystal Structure of the primase fragment of Bacteriophage T7 primase-helicase protein (2003) (0)
Template recognition sequence for RNA primer synthesis by gene 4 protein of bacteriophage T 7 * ( DNA initiation / primase / lagging-strand synthesis / Okazald fragments / DNA synthesis ) (2003) (0)
A DNA binding loop in the gene 4 helicase‐primase of bacteriophage T7 (2006) (0)
A method for nucleic acid hibridisierung with use of single-stranded DNA-binding protein (1993) (0)
The production of synthetic DNA and their use in the synthesis of large polypeptides (1987) (0)
The Bifunctional Primase‐Helicases of Bacteriophage T7 and Arabidopsis thaliana (2006) (0)
DNA polymerases that have a binding site with modified for DNA sequencing nucleotides. (1994) (0)
Potent DNA Strand Annealing Mediated by the T7 Single‐Stranded DNA Binding Protein gp2.5 (2017) (0)
Nucleotide Kinase of Bacteriophage T 7 1 Characterization of a Nucleotide Kinase Encoded by Bacteriophage T 7 * (2012) (0)
Binding Study of T7 Gene 2.5 Protein to Single- and Double--Stranded DNA from Single Molecule Stretching (2006) (0)
CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE4 PROTEIN OF BACTERIOPHAGE T7 (1999) (0)
Characterization and modification of phage T7 DNA polymerase for use in DNA sequencing; Progress report, June 1, 1990--May 31, 1993 (1993) (0)
Molecular mechanisms in DNA replication and recombination : proceedings of a UCLA Symposium held at Keystone, Colorado, March 27-April 3, 1989 (1990) (0)
Residues located in the primase domain of the bacteriophage T7 primase-helicase are essential for loading the hexameric complex onto DNA (2022) (0)
DNA polymerase modified nukleotidbindingssted for DNA sequence analysis (1994) (0)
Template recognition sequence for I protein of bacteriophage T7* (DNA initiation/primase/lagging-strand synthesis/Okazaki fragments/ (2016) (0)
CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DATP (1999) (0)
A Lethal Replication Roadblock Imposed by a Catalytically Inactive DNA Polymerase (2019) (0)
Role of the linker between the zinc binding domain and the polymerization domain of the bacteriophage T7 DNA primase (2006) (0)
Molecular Basis of dTTP Specificity by Gene 4 DNA Helicase of Bacteriophage T7 (2008) (0)
Interaction of the C-terminal tail of the DNA helicase of bacteriophage T7 with a basic patch in T7 DNA polymerase critical for initiation of leading strand DNA synthesis (2011) (0)
An RNA polymerase from the ocean improves in vitro RNA synthesis (560.1) (2014) (0)
polymerase reveal mechanisms of mutagenesis Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T 7 DNA (2004) (0)
DNA polymerases that are modified nukleotidisitoutumiskohta for DNA sequencing (1997) (0)
Unraveling the catalytic mechanism of the bacteriophage T7 gene 4 helicase (2005) (0)
University of Groningen Single-molecule studies of DNA replication (2017) (0)
T7 DNA polymerase in complex with an N-2-acetylaminofluorene-adducted DNA (2004) (0)

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