Charles Heidelberger

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Charles Heidelberger's Degrees

PhD Biochemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

Why Is Charles Heidelberger Influential?

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According to Wikipedia, Charles Heidelberger was a cancer researcher who developed and patented an anticancer drug called 5-Fluorouracil that remains widely used against cancers of the stomach, colon and breast. He was also director of basic research at the University of Southern California's Comprehensive Cancer Center. He received an American Cancer Society National Award in 1974. Heidelberger served on editorial boards of various scientific journals: Cancer Research, Molecular Pharmacology, Biochemical Pharmacology, the International Journal of Cancer, In Vitro, and the Journal of Medicinal Chemistry. He served as director for Basic Research of the USC Cancer Center, and was a Distinguished Professor at the University of Southern California. His former home in Madison, Wisconsin, now known as the Dr. Charles and Judith Heidelberger House, is listed on the National Register of Historic Places.

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Charles Heidelberger's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds (1957) (1431)
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. (1973) (1087)
Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. (1973) (879)
Selective heat sensitivity of cancer cells. Biochemical and clinical studies (1967) (595)
Studies on fluorinated pyrimidines. II. Effects on transplanted tumors. (1958) (452)
Studies on fluorinated pyrimidines. XIII. Inhibition of thymidylate synthetase. (1961) (416)
THE SYNTHESIS OF 5-FLUOROPYRIMIDINES (1957) (388)
Fluorinated pyrimidines and their nucleosides. (1983) (356)
Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells. (1976) (302)
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. (1982) (277)
Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbons in vitro (1969) (257)
Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo. (1958) (255)
Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo. (1958) (246)
Fluorinated pyrimidines. (1963) (243)
Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. (1983) (217)
Studies on the quantitative biology of hyperthermic killing of HeLa cells. (1973) (217)
Clinical studies with 5-fluorouracil. (1958) (214)
EXPERIMENTAL AND CLINICAL USE OF FLUORINATED PYRIMIDINES IN CANCER CHEMOTHERAPY. (1963) (214)
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate. (1972) (193)
Chemical oncogenesis in culture. (1973) (192)
In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons. (1971) (190)
Studies on fluorinated pyrimidines: VII—the degradative pathway☆☆☆ (1959) (189)
METABOLIC REGULATORY CIRCUITS AND CARCINOGENESIS. (1963) (187)
Selective heat sensitivity of cancer cells. Biochemical and clinical studies. (1967) (183)
Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides. (1965) (181)
Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons. (1972) (177)
Cell cycle dependency of oncogenic transformation induced by N-methyl-N'-nitro-N-nitrosoquanidine in culture. (1974) (176)
An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene. (1971) (172)
Studies on fluorinated pyrimidines. VIII. Further biochemical and metabolic investigations. (1959) (170)
Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons. (1971) (164)
Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides. (1974) (164)
Therapeutic Antiviral Action of 5-Trifluoromethyl-2'-deoxyuridine in Herpes Simplex Keratitis (1964) (156)
Studies on Fluorinated Pyrimidines XVI. Metabolism of 5-Fluorouracil-2-C14 and 5-Fluoro-2′-deoxyuridine-2-C14 in Cancer Patients (1963) (153)
Liver homogenate-mediated mutagenesis in chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins. (1977) (148)
STUDIES OF FLUORINATED PYRIMIDINES. XVIII. THE DEGRADATION OF 5-FLUORO-2'-DEOXYURIDINE AND RELATED COMPOUNDS BY NUCLEOSIDE PHOSPHORYLASE. (1963) (143)
Transformation of C3H/10T1/2 CL8 mouse embryo fibroblasts by ultraviolet irradiation and a phorbol ester (1976) (143)
Studies on fluorinated pyrimidines. XI. In vitro studies on tumor resistance. (1960) (141)
SYNTHESES OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE. (1964) (136)
Binding of tritium-labeled polycyclic hydrocarbons to DNA of mouse skin. (1967) (131)
Transformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons. (1972) (130)
Studies on fluorinated pyrimidines. IX. The degradation of 5-fluorouracil-6-C14. (1960) (130)
Intracellular distribution of radioactivity in nucleic acid nucleotides and proteins following simultaneous administration of P32 and glycine-2-C14. (1953) (126)
Influence of drugs and synchrony on the hyperthermic killing of HeLa cells. (1973) (126)
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase. (1979) (124)
In vitro malignant transformation by methylcholanthrene of the progeny of single cells derived from C3H mouse prostate. (1970) (119)
Studies on fluorinated pyrimidines. V. Effects on nucleic acid metabolism in vitro. (1958) (118)
Effects of elevated temperatures and drugs on the viability of L1210 leukemia cells. (1970) (117)
Fluorinated Pyrimidines VI. Effects of 5-Fluorouridine and 5-Fluoro-2′-Deoxyuridine on Transplanted Tumors.∗ † (1958) (116)
The interaction of carcinogenic hydrocarbons with tissue constituents. IV. A quantitative study of the binding to skin proteins of several C14-labeled hydrocarbons. (1956) (112)
Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells. (1978) (112)
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture. (1970) (102)
Comparative studies of fluorinated pyrimidines with various cell lines. (1968) (101)
The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture. (1971) (98)
Growth of carcinoma implants in fed and fasted rats. (1952) (93)
Chemical carcinogenesis (1977) (91)
The mutagenicity to mammalian cells of pyrimidine nucleoside analogs. (1972) (89)
Metabolism of polycyclic aromatic hydrocarbons in cell cultuires. (1971) (87)
The comparative utilization of uracil-2-C14 by liver, intestinal mucosa, and Flexner-Jobling carcinoma in the rat. (1957) (87)
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine. (1980) (87)
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity. (1979) (86)
Mutagenesis of Chinese hamster cells is facilitated by thymidine and deoxycytidine (1978) (85)
Interaction of carcinogenic hydrocarbons with tissues. VIII. Binding of tritiumlabeled hydrocarbons to the soluble proteins of mouse skin. (1962) (84)
The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells. (1981) (83)
In vitro malignant transformation of cells derid from mouse prostate in the presence of 3-methylcholanthrene. (1969) (82)
Determination of the mutagenic activity to bacteriophage T4 of carcinogenic and noncarcinogenic compounds. (1970) (81)
The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine. (1972) (80)
Endogenous oncornaviruses in chemically induced transformation. I. Transformation independent of virus production. (1975) (78)
The metabolism of P32-labeled ribonucleotides in tissue slices and cell suspensions. (1955) (78)
Binding of K-region epoxides and other derivatives of benz(a)anthracene and dibenz(a,h)anthracene to DNA, RNA, and proteins of transformable cells. (1972) (77)
Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts. (1979) (77)
The interaction of carcinogenic hydrocarbons with tissue constituents. I. Methods. (1953) (76)
Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin. (1978) (76)
STUDIES ON THE MOLECULAR MECHANISM OF HYDROCARBON CARCINOGENESIS. (1964) (74)
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides. (1976) (73)
Naphthoquinone Antimalarials. I. General Survey1,2 (1948) (71)
Influence of "feeder cells" and inducers and inhibition of microsomal mixed-function oxidases on hydrocarbon-induced malignant transformation of cells derived from C3H mouse prostate. (1972) (68)
Probabilistic view of the transformation of cultured C3H/10T1/2 mouse embryo fibroblasts by 3-methylcholanthrene. (1980) (65)
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis. (1982) (65)
Antigenicity of clones of mouse prostate cells transformed in vitro (1972) (65)
Current trends in chemical carcinogenesis. (1973) (64)
Malignant transformation in vitro with carcinogenic hydrocarbons. (1967) (64)
Cancer chemotherapy with purine and pyrimidine analogues. (1967) (63)
BIOCHEMICAL MECHANISMS OF ACTION OF FLUORINATED PYRIMIDINES. (1963) (60)
Fluorinated pyrimidines. XXXVII. Effects of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture. (1970) (59)
Syntheses of 5-Trifluoromethyluracil and 5-Trifluoromethyl-2″-Deoxyuridine (1962) (58)
Studies on fluorinated pyrimidines. X. In vivo studies on tumor resistance. (1960) (58)
Effects of promoters on DNA synthesis in C3H/10T1/2 mouse fibroblasts. (1977) (58)
The distribution of radioactivity in mice following administration of 3,4-benzpyrene-5-C14 and 1,2,5,6-dibenzanthracene-9,10-C14. (1951) (57)
Studies on Fluorinated Pyrimidines XVII. Tissue Distribution of 5-Fluorouracil-2-C14 and 5-Fluoro-2′-deoxyuridine in Cancer Patients (1963) (57)
The metabolism of benzo(alpha)pyrene by cytochrome P-450 in transformable and nontransformable C3H mouse fibroblasts. (1979) (55)
Biosynthesis of ‘Asymmetric’ Citric Acid: a Substantiation of the Ogston Concept (1949) (55)
Tryptophan metabolism; concerning the mechanism of the mammalian conversion of tryptophan into nicotinic acid. (1949) (55)
Studies of fluorinated pyrimidines. XV. Inhibition of the incorporation of formate-C14 into DNA thymine of Ehrlich ascites carcinoma cells by 5-fluoro-2'-deoxyuridine-5'-monophosphate and related compounds. (1962) (54)
FLUORINATED PYRIMIDINES. XXI. THE TUMOR-INHIBITORY ACTIVITY OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE. (1964) (54)
Cultivation in vitro of cells derived from adult C3H mouse ventral prostate. (1969) (53)
Tryptophan metabolism; concerning the mechanism of the mammalian conversion of tryptophan into kynurenine, kynurenic acid, and nicotinic acid. (1949) (49)
Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines. (1982) (49)
FLUORINATED PYRIMIDINES. XXIV. IN VIVO METABOLISM OF 5-TRIFLUOROMETHYLURACIL-2-C-14 AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE-2-C-14. (1965) (48)
The effect of modifiers of microsomal enzymes on chemical oncogenesis in cultures of C3H mouse cell lines. (1976) (48)
Isolation and degradation of DNA from cells treated with tritium-labeled 7,12-dimethylbenz(a)anthracene: studies on the nature of the binding of this carcinogen to DNA. (1969) (46)
Partial purification of soluble protein from mouse skin to which carcinogenic hydrocarbons are specifically bound. (1970) (45)
DNA damage and its repair in transformable mouse fibroblasts treated with N-methyl-N'-nitro-N-nitrosoguanidine. (1974) (44)
Oncogenesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents. (1979) (44)
The metabolism of methylated aminoazo dyes. I. The demethylation of 3-methyl-4-dimethyl-C14 amino-azobenzene in vivo. (1952) (44)
The interaction of carcinogenic hydrocarbons with tissue constituents. II. 1,2,5,6-Dibenzanthracene-9,10-C14 in skin. (1953) (43)
MOUSE EPIDERMAL CELLS AND CARCINOGENESIS. I. ISOLATION OF SKIN CONSTITUENTS. (1965) (43)
ON THE REPORTED SOLUBILIZATION OF CARCINOGENIC HYDROCARBONS IN AQUEOUS SOLUTIONS OF DNA. (1964) (43)
Studies on the Structure of the Skin Protein-bound Compounds Following Topical Application of 1,2,5,6-Dibenzanthracene-9,10-C14. I. 2-Phenylphenanthrene-3,2'-dicarboxylic Acid, a Degradation Product1,2 (1955) (43)
Incorporation of glycine-2-C14 into proteins and nucleic acids of the rat. (1951) (42)
Specific incorporation of adenosine-5'phosphate-32P into ribonucleic acid in rat liver homogenates. (1956) (42)
Studies on nucleic acid biosynthesis in Ehrlich ascites cells suspended in a medium permitting growth. (1959) (41)
Antigenicity of cells derived from mouse prostate cells after malignant transformation in vitro by carcinogenic hydrocarbons. (1970) (41)
Naphthoquinone Antimalarials. IV-XI. Synthesis1 (1948) (41)
Chemical Preparation of Asymmetrically Labeled Citric Acid1 (1950) (39)
Fluorinated pyrimidines. XXVII. Attempts to determine transcription errors during the formation of fluorouracil-containing messenger ribonucleic acid. (1966) (38)
Fluorinated pyrimidines. 38. The incorporation of 5-trifluoromethyl-2'-deoxyuridine into the deoxyribonucleic acid of vaccinia virus. (1970) (38)
The refractoriness of the skin of hairless mice to chemical carcinogenesis. (1970) (38)
Studies on the cellular and molecular mechanisms of hydrocarbon carcinogenesis. (1970) (37)
Studies on the organ culture of human tumors. (1966) (37)
Studies on the Structure of the Skin Protein-bound Compounds Following Topical Application of 1,2,5,6-Dibenzanthracene-9,10-C14. II. Nature of the 2-Phenylphenanthrene-3,2'-dicarboxylic Acid-Protein Bond1,2 (1956) (36)
Fluorinated pyrimidines. XL. The reduction of 5-fluorouridine 5'-diphosphate by ribonucleotide reductase. (1972) (36)
Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts. (1982) (35)
Effect of 12-O-tetradecanoylphorbol-13-acetate on the morphology and growth of C3H/10T1/2 mouse embryo cells. (1980) (35)
Determination of the h-protein in transformable and transformed cells in culture. (1972) (35)
In vivo studies on incorporation of glycine-2-C14 into proteins and nucleic acid purines. (1952) (34)
The influence of serum components on the growth and mutation of Chinese hamster cells in medium containing 8-azaguanine. (1976) (34)
A rapid and sensitive liquid chromatographic assay for epoxide hydrase. (1975) (33)
Purification of thymidylate synthetase from Ehrlich ascites carcinoma cells. (1971) (33)
The distribution of radioactivity in the mouse following administration of dibenzanthracene labeled in the 9 and 10 positions with carbon 14 (1948) (33)
INCORPORATION OF I-125-LABELED IODODEOXYURIDINE INTO THE DEOXYRIBONUCLEIC ACID OF MURINE AND HUMAN TISSUES FOLLOWING THERAPEUTIC DOSES. (1963) (33)
The metabolism of benz(a)anthracene and dibenz(a,h)anthracene and their related "K-region" epoxides, cis-dihydrodiols and phenols by hamster embryo cells. (1973) (33)
The isolation and characterization of polycyclic hydrocarbon-binding proteins from mouse liver and skin cytosols. (1975) (33)
Assay and time course of 5-fluorouracil incorporation into RNA of L1210/0 ascites cells in vivo. (1985) (32)
Inhibition of induced differentiation of C3H/10T 1/2 clone 8 mouse embryo cells by tumor promoters. (1980) (31)
Inhibition of nucleoside phosphorylase cleavage of 5-fluoro-2'-deoxyuridine by 2,4-pyrimidinedione derivatives. (1980) (31)
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine. (1967) (30)
Neoantigens on chemically transformed cloned C3H mouse embryo cells. (1975) (28)
Cell cycle dependency of DNA damage and repair in transformable mouse fibroblasts treated with N-methyl-N'--nitro-N-nitrosoguanidine. (1974) (28)
Hydrolysis of syn- and anti-benzo[a]pyrene diol epoxides: stereochemistry, kinetics, and the effect of an intramolecular hydrogen bond on the rate of syn-diol epoxide solvolysis (1976) (28)
Local functional components of carcinogenesis. (1961) (28)
Concerning the mechanism of the mammalian conversion of tryptophan into kynurenine, kynurenic acid, and nicotinic acid. (1948) (27)
Destruction of amino acids during filter paper chromatography. (1951) (27)
The interaction of carcinogenic hydrocarbons with tissues. V. Some structural requirements for binding of 1,2,5,6-dibenzanthracene. (1958) (27)
Reversion of the 8-azaguanine resistant phenotype of variant Chinese hamster cells treated with alkylating agents and 5-brono-2'-deoxyuridine. (1975) (26)
The effect of Raney nickel on the covalent thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate complex. (1976) (25)
Alternative metabolic pathways. (1950) (24)
Attempts to produce carcinogenesis in organ cultures of mouse prostate with polycyclic hydrocarbons (1967) (24)
Intramolecular Heterogeneity in Nucleic Acid Biosynthesis1,2 (1954) (24)
Breakdown of HeLa cell DNA mediated by vaccinia virus. (1973) (24)
On the rational development of a new drug: the example of the fluorinated pyrimidines. (1981) (24)
Diphenamid metabolism in plants. (1967) (24)
Separation of glutathione S-transferase activities with epoxides from the mouse liver h-protein, a major polycyclic hydrocarbon-binding protein. (1978) (24)
ON THE MOLECULAR MECHANISM OF THE ANTIVIRAL ACTIVITY OF TRIFLUOROTHYMIDINE * (1975) (24)
Concerning the mechanism of the mammalian conversion of tryptophan into nicotinic acid. (1948) (23)
FLUORINATED PYRIMIDINES. XX. INHIBITION OF THE NUCLEOSIDE PHOSPHORYLASE CLEAVAGE OF 5-FLUORO-2'-DEOXYURIDINE BY 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE. (1963) (23)
The oxidation of acetate-1-C14 by rat tissue in vitro. (1950) (23)
Incorporation of labelled ribonucleoside-5′-monophosphates into ribonucleic acid in a cytoplasmic fraction of rat-liver homogenates (1959) (23)
Metabolic activation of benzo(a)pyrene by transformable and nontransformable C3H mouse fibroblasts in culture. (1982) (23)
The potentiation by 5-iodo-2'-deoxyuridine (IUDR) of the tumor-inhibitory activity of 5-fluoro-2'-deoxyuridine (FUDR). (1960) (23)
The Metabolic Degradation in the Mouse of 1,2,5,6-Dibenzanthracene-9,10-C14. III. Some Quinone Metabolites Retaining the Intact Ring System1-3 (1953) (22)
Studies on Fluorinated Pyrimidines. XIV. The Synthesis of Derivatives of 5-Fluoro-2'-deoxyuridine 5'-Phosphate and Related Compounds1 (1962) (22)
The interaction of carcinogenic hydrocarbons with tissues. VII. Fractionation of mouse skin proteins. (1961) (22)
Fluorinated pyrimidines. XLIV. Interaction of 5-trifluoromethyl-2'-deoxyuridine 5'-triphosphate with deoxyribonucleic acid polymerases. (1973) (22)
Polycyclic k-region arene oxides. Products and kinetics of solvolysis. (1976) (22)
The role of chemicals and radiation in the etiology of cancer. (1985) (22)
Comparison of adriamycin- and ouabain-induced cytotoxicity and inhibition of 86rubidium transport in wild-type and ouabain-resistant C3H/10T1/2 mouse fibroblasts. (1980) (21)
Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase. (1981) (21)
Separate identities of ligandin and the h-protein, a major protein to which carcinogenic hydrocarbons are covalently bound. (1976) (21)
S-9 metabolic activation enhances aflatoxin-mediated transformation of C3H/10T1/2 cells. (1985) (20)
Purification of thymidylate synthetase from L. casei by affinity chromatography. (1972) (20)
The metabolic degradation in the mouse of dibenzanthracene labeled in the 9 and 10 positions with carbon 14 (1948) (19)
The carcinogenic activities of various derivatives of dibenzanthracene. (1962) (19)
Metabolism of pyruvate in tumor homogenates. (1952) (19)
Applications of radioisotopes to studies of carcinogenesis and tumor metabolism. (1953) (19)
Fluorinated Pyrimidines. XXVIII. The Synthesis of 5-Trifluoromethyl-6-azauracil and 5-Trifluoromethyl-6-aza-2'-deoxyuridine1 (1966) (19)
Oncogenic transformation and mutation of C3H/10T 1/2 clone 8 mouse embryo fibroblasts by alkylating agents. (1981) (19)
Pyridine nucleosides related to 5-fluorouracil and thymine. (1973) (19)
The Synthesis of the Mono- and Dihydroxy Derivatives of 1,2,5,6-Dibenzanthracene Excreted by the Rabbit and of Other Hydroxylated Dibenzanthracene Derivatives1 (1958) (18)
Further evidence that ouabain-resistant variants induced by chemical carcinogens in transformable C3H/10T1/2 Cl 8 mouse fibroblasts are mutants. (1980) (18)
NAPHTHOQUINONE ANTIMALARIALS: XVIII. Metabolic Oxidation Products (1948) (18)
The Interaction of Carcinogenic Hydrocarbons with Tissues VI. Studies on Zero-Time Binding to Proteins (1961) (18)
Studies on OPSPA. I. The effect of several phosphoramides on transplanted tumors. (1957) (18)
The synthesis of 3,4-benzpyrene-5-C14 and of 2-acetylaminofluorene-9-C14. (1951) (18)
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection. (1982) (17)
The interaction of carcinogenic hydrocarbons with tissue constituents. III. 1,2,5,6-Dibenzanthracene-9.10-C14 in the submaxillary gland. (1953) (17)
The Synthesis of Oxalacetic Acid-1-C14 and Orotic Acid-6-C14 1 (1950) (17)
Studies on OPSPA. II. Distribution and excretion of radioactivity following administration of OPSPA-C14 and OPSPA-P32 to the rat. (1957) (17)
Automatic direct quantitation of radioactivity on paper chromatograms. (1960) (16)
Effects of praziquantel, a new antischistosomal drug, on the mutation and transformation of mammalian cells. (1982) (16)
The Synthesis of 1,2,5,6-Dibenzanthracene Labeled in the 9-Position with Carbon-141 (1947) (16)
Growth inhibition of cells in cultures and of vaccinia virus infected HeLa cells by derivatives of trifluorothymidine. (1976) (16)
Combined chemotherapy and irradiation in inoperable bronchogenic carcinoma (1962) (16)
Some effects of 5-fluoroorotic acid and 5-fluorouracii, on the soluble ribonucleic acid of rat liver (1962) (16)
The synthesis of DL-tryptophan-beta-C14, indole-3-acetic acid-alpha-C14, and DL-tryptophan-3-C14. (1949) (16)
Mutation of Chinese Hamster V79 cells and transformation and mutation of mouse fibroblast C3H/10T1/2 clone 8 cells by aflatoxin B1 and four other furocoumarins isolated from two Nigerian medicinal plants. (1983) (16)
Studies on OPSPA. IV. Metabolism of OPSPA in the rat and human. (1957) (15)
Malignant transformation in vitro by carcinogenic hydrocarbons. (1967) (15)
Cytotoxicity and mutagenicity of ultraviolet irradiation as a function of the interval between split doses in cultured Chinese hamster cells. (1973) (14)
The need for additional alkylating agents and antimetabolites. (1969) (14)
FLUORINATED PYRIMIDINES. XXV. THE INHIBITION OF THYMIDYLATE SYNTHETASE FROM EHRLICH ASCITES CARCINOMA CELLS BY PYRIMIDINE ANALOGS. (1965) (14)
FLUORINATED PYRIMIDINES. XIX. SOME BIOLOGICAL EFFECTS OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE ON ESCHERICHIA COLI AND BACTERIOPHAGE T4B. (1963) (14)
Cytotoxicity, mutations and DNA damage produced in Chinese hamster cells treated with streptozotocin, its analogs, and N-methyl-N'-nitro-N-nitrosoguanidine. (1976) (14)
The metabolic degradation in the mouse of 1,2,5,6-dibenzanthracene-9,10-C14. II. 5-Hydroxy-1,2-naphthalic acid, a new metabolite. (1951) (13)
Cyclopenta[f]isoquinoline derivatives designed to bind specifically to native deoxyribonucleic acid. 1. Synthesis of 3-ethoxy-8-methyl-7(5)H-cyclopenta[f]isoquinoline. (1975) (12)
Cyclopenta(f)isoquinoline derivatives designed to bind specifically to native deoxyribonucleic acid. 3. Interaction of 6-carbamylmethyl-8-methyl-7H-cyclopenta(f)isoquinolin-3(2H)-one with deoxyribonucleic acids and polydeoxyribonucleotides. (1974) (11)
Synthesis of 5‐ethynylorotic acid (1981) (11)
Utilization of host-cell DNA by vaccinia virus replicating in HeLa cells irradiated intranuclearly with tritium. (1971) (10)
Further studies of the lethal effects of heat on tumor cells. Abstr. (1969) (10)
The effects of twenty-nine compounds on nucleic acid and protein biosynthesis in slices of Flexner-Jobling carcinoma and rat spleen. (1955) (10)
Fluorinated pyrimidines. 33. Synthesis of methylated 5-fluoro-2'-deoxyuridine derivatives. (1970) (10)
Some Biochemical Problems of Cancer Chemotherapy (1957) (9)
In vitro synthesis of acidsoluble thymine compounds by human neoplastic tissues. (1963) (9)
Characteristics of murine prostatic acid phosphatase: comparison with other tissues and species. (1968) (9)
Pyridine nucleosides related to 5-fluorouracil (1973) (9)
Influence of benzoflavone on aflatoxin B1-induced cytotoxicity, mutation, and transformation of C3H/10T1/2 cells. (1983) (9)
Synthesis and biological studies of 3-(beta-D-ribofuranosyl)-2,3,-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine. (1976) (9)
Fluorinated pyrimidines—XXXV The metabolism of 2′,3′-dehydro-5-fluoro-2′-deoxyuridine in Ehrlich ascites cells (1970) (8)
The influence of serum components on the growth and mutation of Chinese hamster cells in medium containing aminopterin. (1974) (8)
Lack of effect of warfarin (NSC-59813) alone or in combination with 5-fluorouracil (NSC-19893) on primary and metastatic L1210 leukemia and adenocarcinoma 755. (1971) (8)
A new synthesis of n-blocked dihydrouracil and dihydroorotic acid derivatives using lithium tri-sec-butyl borohydride as reducing agent (1980) (8)
Fluorinated pyrimidines. 39. Effects of 5-trifluoromethyl-2'-deoxyuridine on the replication of vaccinia viral messenger ribonucleic acid and proteins. (1971) (8)
Fluorinated pyrimidines. 34. Structure-activity studies of methylated 5-fluoro-2'-deoxyuridine derivatives. (1970) (8)
Defective Binding of 3-Methylcholanthrene to the Ah Roceptor witthin C3H/1OT1/2Clone 8 Mouse Fibroblasts in C (1983) (7)
Inhibition of the growth of cultured cells by arginase and soluble proteins from mouse skin. (1968) (7)
The nucleotides of fluorinated pyrimidines and their biological activities. (1971) (7)
Rapid lysis of vaccinia virus on neutral sucrose gradients with release of intact DNA. (1976) (7)
A new paper-chromatographic method for separation of various pyrimidines and their deoxyribonucleosides. (1959) (7)
Studies on the mechanism of hydrocarbon carcinogenesis. (1959) (7)
Morphological correlates of transformation in cultured C3H/10T1/2 mouse embryo cells. (1984) (7)
Fluorinated pyrimidines. XXIII. Further studies on nucleoside phosphorylase (1964) (7)
Isolation of mutants temperature-sensitive for expression of the transformed state from chemically transformed C3H/10T1/2 cells. (1980) (6)
Rat hepatoma cells show extreme sensitivity to aflatoxin B1. (1982) (6)
In vitro genotoxicity studies using complex hydrophobic mixtures: efficient delivery of a petroleum sample to cultured C3H/10T1/2 cells via lipid vesicle incorporation. (1986) (6)
CHAPTER VII – STUDIES ON THE MOLECULAR AND CELLULAR MECHANISMS OF HYDROCARBON CARCINOGENESIS* (1966) (6)
Synthesis of beta-5-fluoro-2'-deoxyuridylyl-(5'-5')-beta-5-fluoro-2'-deoxyuridine. (1966) (6)
Fluorinated pyrimidines. XXXII. Syntheses of 2',3'-dehydro-5-trifluoromethyl-2'-deoxyuridine and 5-trifluoromethyluridine. (1969) (6)
Determinants of 5-fluorouracil sensitivity in human tumors. (1979) (6)
Genetic and probability aspects of cell transformation by chemical carcinogens. (1983) (5)
Synthesis of a new pyrimidine nucleoside analog related to uridine (1974) (5)
Human cancer, the primary target. (1960) (5)
Stimulation of DNA synthesis in hydrocarbon-transformable hamster embryo cells by the K-region epoxide of benz(a)anthracene. (1972) (5)
Mammalian cell transformation and mammalian cell mutagenesis in vitro. (1980) (5)
Chemically and Metabolically Induced DNA Adducts: Relationship to Chemical Carcinogenesis (1976) (5)
Studies on OPSPA. III. Distribution and excretion of radioactivity following administration of OPSPA-C14 and OPSPA-P32 to humans. (1957) (5)
Chemical carcinogenesis. (1977) (5)
Chemical oncogenesis in cultured mouse embryo cells in relation to the cell cycle (1975) (5)
Biochemistry of Human Tumours (1961) (5)
Fluorinated Pyrimidines, Biochemically and Clinically Useful Antimetabolites (1966) (5)
Fluorinated pyrimidines. 41. Syntheses of 5-trifluoromethyl-3'-deoxyuridine and 5-fluoro-3'-deoxyuridine. (1972) (5)
An unusual arene oxide reaction. Solvent capture during acid-catalyzed solvolysis of 7,12-dimethylbenz(a)anthracene 5,6-oxide. (1976) (5)
Effects of tumor promoters on the differentiation of C3H/10T 1/2 mouse embryo fibroblasts. (1982) (4)
Synthesis of 5-trifluoromethyl-2'-deoxyuridine 5'-phosphate and 5-trifluoromethyl-2'-deoxyuridine 5'-triphosphate. (1973) (4)
Defective binding of 3-methylcholanthrene to the Ah receptor within C3H/1OT1/2 clone 8 mouse fibroblasts in culture. (1983) (4)
Liver-homogenate mediated mutagenesis in Chinese hamster V79 cells by chemical carcinogens (1976) (4)
[STUDIES ON THE MOLECULAR MECHANISM OF CARCINOGENESIS CAUSED BY HYDROCARBONS]. (1965) (4)
Partition Chromatographic Separation of Aromatic Acids1 (1955) (4)
Fluorinated pyrimidines. XLII. Effect of 5-trifluoromethyl-1-2'-deoxyuridine on transcription of vaccinia viral messenger ribonucleic acid. (1973) (4)
Malignant Transformation of Cells in Culture Using Oncogenic Chemicals (1973) (4)
The preparation and purification of tritiated carcinogenic hydrocarbons. (1962) (4)
Synthesis of 5-carboxy-2'-deoxyuridine. (1967) (3)
Cyclopenta[f]isoquinoline derivatives designed to bind specifically to native deoxyribonucleic acid. 2. Synthesis of 6-carbamylmethyl-8-methyl-7(5)H-cyclopenta[f]isoquinolin-3(2H)-one and its interaction with deoxyribonucleic acids and poly(deoxyribonucleotides). (1975) (3)
Cell-cycle dependency of chemical oncogenic transformation in culture. Abstr. (1973) (3)
Lack of direct correlation among repair, oncogenesis, and lethality in cultured synchronized mouse fibroblasts treated with N-methyl-N'-nitro-N-nitrosoguanidine. (1975) (3)
Mutation and transformation in chinese hamster v79 cells and c3h mouse fibroblast 10t1/2 cells by aflatoxin b1 and four other furocoumarins isolated from two nigerian medicinal plants. Abstr. (1982) (3)
Pyridine nucleosides related to 5-fluorocytosine (1975) (3)
The Effects of Microsomal Enzymes on Chemical Oncogenesis in Culture (1977) (3)
The inhibition of thymidylate synthetase by 5-fluoro-2'-deoxyuridine- -5'-monophosphate (fudrp). Abstr. (1961) (3)
2-Phenylphenanthrene-3,2'-dicarboxylic acid is not bound to mouse skin proteins after application of 1,2,5,6-dibenzanthracene: a retraction. (1969) (3)
Some reflections and speculations about chemical carcinogenesis. (1967) (3)
Increased thymidine uptake by methylcholanthrene‐treated C3H/10T1/2 cells (1975) (3)
POLYCYCLIC K-REGION ARENE OXIDES. PRODUCTS AND KINETICS OF SOLVOLYSIS (1976) (3)
METABOLISM OF BENZO(A)PYRENE AND ONCOGENIC TRANSFORMATION OF C3H/10T1/2 MOUSE EMBRYO FIBROBLASTS (1980) (3)
Tryptophan Metabolism II. (1949) (3)
Effect of steroids and fluoropyrimidines on lymphomas. II. In vivo studies on tumor resistance and collateral sensitivity. (1963) (3)
Ultraviolet light in the oncogenic transformation of cultured C3H/10T1/2 mouse embryo cells. (1978) (3)
PHOTOBIOLOGICAL ACTIVITY OF MARMESIN (5‐B‐HYDROXYISOPROPYL‐4–5 DIHYDROFUROCOUMARIN) IN CHINESE HAMSTER V79 CELLS (1983) (2)
Development of two cloned epithelial cell lines from normal adult mouse and rat ventral prostates (1981) (2)
Studies on the Cellular Mechanisms of Chemical Oncogenesis in Culture (1975) (2)
Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism. (1985) (2)
Fluorinated pyrimidines. 28. The synthesis of 5-trifluoromethyl-6-azauracil and 5-trifluoromethyl-6-aza-2'-deoxyuridine. (1966) (2)
The incorporation of trifluorothymidine into calf thymus DNA in a cell-free system does not lead to chain termination. (1980) (2)
The application of the carbon isotopes to a study of animal metabolism. (1951) (2)
Association between the cytotoxicity of thymidine and tumorigenicity of clones derived from C3H/10T1/2 mouse embryo fibroblasts. (1980) (2)
The induction of Ouar-mutations in nontransformable CVP3SC6 mouse fibroblasts. (1982) (2)
In vitro malignant transformation of mouse prostate cells with car- cinogenic hydrocarbons. Abstr. (1968) (1)
Induction of ouabain-resistant mutants by chemical carcinogens in rat prostate epithelial cells. (1983) (1)
Biochemical approaches to new cancer chemotherapeutic agents. (1970) (1)
In Vitro Carcinogenesis with Cell Lines (1983) (1)
Cell differentiation and tumor promotion. Abstr. (1980) (1)
Biochemistry of Cancer (1976) (1)
Fluorinated pyrimidines. XXXVI. Synthesis of some 2,4-substituted 5-trifluoromethylpyrimidines. (1970) (1)
Establishment of epithelial cell lines from adult mouse regenerating liver (1979) (1)
Isolation and characterization of mutant leukemic cell lines resistant to fluorinated pyrimidines. Abstr. (1980) (1)
Synthesis and Biological Studies of 3-(β-D-Ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a New Pyrimidine Nucleoside Analog Related to Uridine. (1976) (1)
INTERACTION OF 5-ETHYNYL-2′-DEOXYURIDYLATE WITH THYMIDYLATE SYNTHETASE (1982) (1)
Initiation, promotion, transformation, and mutagenesis of mouse embryo cell lines. (1983) (1)
Cancer and the environment: overview. (1980) (1)
FLUORINATED PYRIMIDINES. XXII. EFFECTS OF VARIOUS COMPOUNDS ON THE INCORPORATION OF (14C)FORMATE INTO DNA THYMINE IN SUSPENSIONS OF EHRLICH ASCITES CELLS. (1964) (1)
Tryptophan Metabolism I. (1949) (1)
Biochemical and biological effects of heat on normal and neoplastic cells. Abstr. (1968) (1)
Purification and properties of thymidylate synthetase of ehrlich ascites tumor cells. Abstr. (1970) (0)
Incorporation of 5-trifluoromethyl-2'-deoxyuridine (f3tdr) into dna of l5178y cells and vaccinia virus. Abstr. (1970) (0)
A cell-mediated mutagenesis assay for dimethylnitrosamine in c3h/10t1/2 cells. Abstr. (1982) (0)
Negative data from cancer chemotherapy screening. (1958) (0)
Oncogenic Transformation, Initiation, Promotion and Mutagenesis in C3H/10T1/2 Cells (1980) (0)
Some effects of 5-fluoroorotic acid and 5-fluorouracii on the soluble acid of rat liver. (1962) (0)
Purification of thymidylate synthetase with 2'-deoxyuridylate-agarose. (1974) (0)
Contents of Volume 1 (1983) (0)
PYRIDINE NUCLEOSIDES RELATED TO 5-FLUORO-URACIL AND THYMINE (1973) (0)
SYNTHESIS OF 5-ETHYNYLOROTIC ACID (1981) (0)
Incorporation of labeled ribonucleoside-5'-monophosphates into ribonucleic acid in a cytoplasmic fraction of rat-liver homogenates. (1959) (0)
Micro cell mediated chromosome transfer of chemical carcinogen induced ouabain resistance from ouabain resistant c 3h 10t 1 2 cl 8 cells to human d 98 cells (1981) (0)
FACILITATION BY PYRIMIDINE NUCLEOSIDES AND HYPOX-ANTHINE OF MNNG MUTAGENESIS IN CHINESE HAMSTER CELLS (1979) (0)
Exploration of the active site of mammalian thymidylate synthetase. Abstr. (1972) (0)
The tumor-inhibitory activity of 5-tri-fluoromethyl-2'-deoxyuridine (f3tdr). Abstr. (1964) (0)
CYCLOPENTA(F)ISOQUINOLINE DERIVATIVES DESIGNED TO BIND SPECIFICALLY TO NATIVE DEOXYRIBONUCLEIC ACID PART 2, SYNTHESIS OF 6-CARBAMYLMETHYL-8-METHYL-7(5)H-CYCLOPENTA(F)ISOQUINOLIN-3(2H)-ONE AND ITS INTERACTION WITH DEOXYRIBONUCLEIC ACID (1975) (0)
Influenceof Benzoflavone onAflatoxinBHnducedCytotoxicity, Mutation,andTransformation of C3H/10T1/2Cells1'2 (1983) (0)
Transformation of cultured c3h/10t1/2 cells by ultraviolet light and phorbol ester. Abstr. (1976) (0)
Syncarcinogenesis in cultured c3h/10t1/2 cells. Abstr. (1977) (0)
Alkaline sucrose sedimentation studies of dna lesions that impede dna synthesis in transformable mouse fibroblasts treated with methylating agents. Abstr. (1976) (0)
16 – Oncogenic Transformation of Cell Cultures by Polycyclic Aromatic Hydrocarbons and Their Derivatives (1978) (0)
Alkali-labile lesions, DNA synthesis, and mutagenesis in cultured mammalian cells (1978) (0)
CHEMICAL CARCINOGENESIS :~875 (1975) (0)
Effects of phorbol esters on dna synthesis in c3h/10t1/2 mouse fibroblasts. Abstr. (1977) (0)
Enhancement of therapeutic response to fluorinated pyrimidines by coadminstration of inhibitors of deoxyuridylate (dump) synthesis. Abstr. (1978) (0)
Improved scoring of chemical transformation of C3H/10T1/2 cells (1981) (0)
Effects of phorbol esters on 2-deoxy-d-glucose uptake by c3h/10t1/2 mouse embryo fibroblasts. Abstr. (1978) (0)
Detection and Identification of Common Oncofetal Antigens on in Vitro Transformed Mouse Fibroblasts (1983) (0)
GENETICS:BAKER AND SGOURAKIS * Theseinvestigations weresupported inpartbytheWilliams-Waterman Fundfor thecombatofdietary diseases, andinpartbytheRockefeller Foundation. tTheauthors wishtothankDr.W.Weidel oftheKaiser-Wilhelm Institut furBio- chemie, whogenerously madeasample of3-hydroxykynurenine (1950) (0)
Studies on the Cellular Mechanisms of Chemical Oncogenesis (1978) (0)
CYCLOPENTA(F)ISOQUINOLINE DERIVATIVES DESIGNED TO BIND SPECIFICALLY TO NATIVE DEOXYRIBONUCLEIC ACID PART 1, SYNTHESIS OF 3-ETHOXY-8-METHYL-7(5)H-CYCLOPENTA(F)ISOQUINOLINE (1975) (0)
Probabilistic view of the transformation of cultured C 3 H / 1 OTL / 2 mouse embryo fibroblasts by 3-methylcholanthrene ( cell transformation / chemical carcinogenesis ) (0)
Letter from Charles Heidelberger (Michael's son) to Michael and Charlotte Rosen Heidelberger (1958) (0)
AN UNUSUAL ARENE OXIDE REACTION. SOLVENT CAPTURE DURING ACID-CATALYZED SOLVOLYSIS OF 7,12-DIMETHYLBENZ(A)ANTHRACENE 5,6-OXIDE (1977) (0)
An estimate of the catalytic-centre activity and purity of human alkaline phosphatase preparations (1968) (0)
RATIONALE FOR THE DESIGN OF FLUORINATED PYRIMIDINES. (1964) (0)
In c3h/10t1/2 cells. Abstr. (1982) (0)
FLUORINATED PYRIMIDINES. 23. FURTHER STUDIES ON NUCLEOSIDE PHOSPHORYLASE. (1964) (0)
[Not Available]. (1949) (0)
SYNTHESIS OF 5-TRIFLUOROMETHYL-2′-DEOXYURIDINE 5′-PHOSPHATE AND 5-TRIFLUOROMETHYL-2′-DEOXYURIDINE 5′-TRIPHOSPHATE (1973) (0)
A common antigen expressed on in vitro polycyclic-hydrocarbon transformed cells. Abstr. (1981) (0)

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