Charles Nicholas Hales

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Charles Nicholas Hales

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Engineering
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Charles Nicholas Hales's Degrees

PhD Physics Stanford University
Bachelors Electrical Engineering California Institute of Technology

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According to Wikipedia, Charles Nicholas "Nick" Hales was an English physician, biochemist, diabetologist, pathologist, and professor of clinical biochemistry Biography After education at King Edward VI Grammar School, Stafford, C. Nicholas Hales matriculated in 1953 at Trinity College, Cambridge, graduating BA in 1956. He studied medicine at University College Hospital Medical School, graduating MB BChir in 1959. At University College Hospital he was a house physician under Max Rosenheim. Hales returned to the University of Cambridge for graduate study in biochemistry. He received in 1964 his PhD under the supervision of Philip Randle.

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Charles Nicholas Hales's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. (1963) (5028)
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis (1992) (2931)
Fetal and infant growth and impaired glucose tolerance at age 64. (1991) (2707)
The thrifty phenotype hypothesis. (2001) (2540)
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth (2004) (2094)
Immunoassay of insulin with insulin antibody preciptate. (1963) (1943)
Immunoassay of insulin with insulin-antibody precipitate. (1963) (766)
Growth in utero and serum cholesterol concentrations in adult life. (1993) (637)
Understanding Oral Glucose Tolerance: Comparison of Glucose or Insulin Measurements During the Oral Glucose Tolerance Test with Specific Measurements of Insulin Resistance and Insulin Secretion (1994) (623)
An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload (1972) (563)
THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL (1985) (531)
Fetal and infant growth and cardiovascular risk factors in women (1995) (468)
Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians (1995) (383)
Organ-selective growth in the offspring of protein-restricted mothers (1996) (376)
INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES (1989) (369)
Catch-up growth and obesity in male mice (2004) (365)
Relation of infant feeding to adult serum cholesterol concentration and death from ischaemic heart disease. (1992) (357)
Fetal Growth and Glucose and Insulin Metabolism in Four‐year‐old Indian Children (1995) (354)
Effects of low-carbohydrate diet and diabetes mellitus on plasma concentrations of glucose, non-esterified fatty acid, and insulin during oral glucose-tolerance tests. (1963) (338)
Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. (1996) (311)
Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young south african adults: early programming of cortisol axis. (2000) (306)
Early growth determines longevity in male rats and may be related to telomere shortening in the kidney (1999) (302)
Thinness at birth and insulin resistance in adult life (1994) (300)
Early programming of glucose–insulin metabolism (2002) (299)
Fetal growth and impaired glucose tolerance in men and women (1993) (294)
ROLE OF FETAL AND INFANT GROWTH IN PROGRAMMING METABOLISM IN LATER LIFE (1997) (293)
Size at birth, maternal weight, and Type 2 diabetes in South India (1998) (286)
Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS). (1999) (277)
THE GLUCOSE FATTY ACID CYCLE IN OBESITY AND MATURITY ONSET DIABETES MELLITUS (1965) (276)
Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring. (2005) (276)
Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet (2001) (272)
Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels (2004) (272)
Plasma glucose, non-esterified fatty acid and insulin concentrations in hypothalamic-hyperphagic rats. (1964) (270)
Labelled Antibodies and Immunological Assay Systems (1968) (266)
Lifespan: Catch-up growth and obesity in male mice (2004) (264)
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. 1992. (2013) (256)
Interactions of metabolism and the physiological role of insulin. (1966) (249)
Ageing and telomeres: a study into organ- and gender-specific telomere shortening. (2003) (240)
Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. (1997) (235)
Adult glucose and lipid metabolism may be programmed during fetal life. (1995) (216)
ATP-Sensitive K+ Channels in Pancreatic β-Cells: Spare-Channel Hypothesis (1988) (214)
Non-insulin-dependent diabetes mellitus. (1997) (213)
The long-term consequences of intra-uterine protein malnutrition for glucose metabolism (1999) (205)
Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams. (1996) (203)
Nutrition in pregnant or lactating rats programs lipid metabolism in the offspring (1996) (198)
The 30 Minute Insulin Incremental Response in an Oral Glucose Tolerance Test as a Measure of Insulin Secretion (1995) (190)
Report of the American Diabetes Association's Task Force on Standardization of the Insulin Assay (1996) (187)
European Association for the study of diabetes (1969) (186)
The glucose-fatty-acid cycle. (1963) (181)
Do different dimensions of the metabolic syndrome change together over time? Evidence supporting obesity as the central feature. (2001) (181)
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide‐sensitive channels in an insulin‐secreting cell line (1988) (177)
Fasting proinsulin concentrations predict the development of type 2 diabetes. (1999) (177)
Glucose tolerance in adults after prenatal exposure to famine (1998) (173)
Altered adipocyte properties in the offspring of protein malnourished rats (1997) (170)
Undiagnosed Glucose Intolerance in the Community: the Isle of Ely Diabetes Project (1995) (168)
Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet. (2004) (162)
Measurement of Insulin Secretion in Type 2 Diabetes: Problems and Pitfalls (1992) (160)
The role of sodium and potassium in insulin secretion from rabbit pancreas (1968) (160)
Thinness at Birth and Glucose Tolerance in Seven‐year‐old Children (1995) (159)
Testing the fetal origins hypothesis in twins: the Birmingham twin study (2001) (159)
The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro (1967) (154)
Fetal growth and adult diseases. (2004) (153)
The maternal endocrine environment in the low-protein model of intra-uterine growth restriction (2003) (150)
Loss of Proliferative Capacity and Induction of Senescence in Oxidatively Stressed Human Fibroblasts* (2004) (147)
For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure* (2003) (146)
Lipolysis in chicken adipose tissue in vitro. (1969) (144)
Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians. (1998) (143)
The response of plasma insulin, glucose and non-esterified fatty acids to various hormones, nutrients and drugs in the domestic fowl. (1970) (139)
RADIOIMMUNOASSAY MAY OVERESTIMATE INSULIN IN NON‐INSULIN‐DEPENDENT DIABETICS (1990) (138)
Early protein restriction and obesity independently induce hypertension in 1-year-old rats. (1997) (136)
Proinsulin Is an Independent Predictor of Coronary Heart Disease: Report From a 27-Year Follow-Up Study (2002) (135)
Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet. (1997) (134)
Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring (2003) (134)
Impaired glucose tolerance and fasting hyperglycaemia have different characteristics (2000) (132)
Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. (1996) (132)
Cations and the secretion of insulin from rabbit pancreas in vitro (1968) (131)
The properties and extracellular location of 5'-nucleotidase of the rat fat-cell plasma membrane. (1975) (129)
Frequent salad vegetable consumption is associated with a reduction in the risk of diabetes mellitus. (1999) (128)
Left ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly men. (2000) (127)
Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring. (2001) (126)
Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments. (2002) (124)
IMPROVEMENT IN INSULIN SECRETION IN DIABETES AFTER DIAZOXIDE (1976) (123)
Fasting and postprandial determinants for the occurrence of small dense LDL species in non-insulin-dependent diabetic patients with and without hypertriglyceridaemia: the involvement of insulin, insulin precursor species and insulin resistance. (1995) (122)
PLASMA-INSULIN CONCENTRATIONS AFTER MYOCARDIAL INFRACTION. (1965) (119)
The electron microscopic localization of cations to pancreatic islets of langerhans and their possible role in insulin secretion (1973) (117)
Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging? (2000) (116)
Effects of size at birth, gestational age and early growth in preterm infants on glucose and insulin concentrations at 9–12 years (2000) (112)
Insulin Deficiency and Increased Plasma Concentration of Intact and 32/33 Split Proinsulin in Subjects with Impaired Glucose Tolerance (1993) (112)
Poor fetal growth followed by rapid postnatal catch-up growth leads to premature death (2005) (111)
Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp (2005) (107)
Hormonal control of adipose tissue lipolysis (1975) (107)
Glucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality. (1997) (105)
A quantitative analysis of the relationship between habitual energy expenditure, fitness and the metabolic cardiovascular syndrome (1998) (105)
Several factors associated with the insulin resistance syndrome are predictors of left ventricular systolic dysfunction in a male population after 20 years of follow-up. (2001) (105)
Loss of the First Phase Insulin Response to Intravenous Glucose in Subjects with Persistent Impaired Glucose Tolerance (1994) (104)
Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. (1997) (104)
Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine (1999) (103)
Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects. (2000) (99)
The Relation of Proinsulin, Insulin, and Proinsulin-to-Insulin Ratio to Insulin Sensitivity and Acute Insulin Response in Normoglycemic Subjects (1997) (98)
The Thrifty Phenotype Hypothesis: How Does it Look After 5 Years? (1997) (98)
Adenosine-5′-triphosphate-sensitive ion channels in neonatal rat cultured central neurones (1988) (97)
The effects of maternal protein deprivation on the fetal rat pancreas: major structural changes and their recuperation (1997) (96)
Long-term programming of blood pressure by maternal dietary iron restriction in the rat (2002) (93)
Dual effects of diazoxide on ATP‐K+ currents recorded from an insulin‐secreting cell line (1989) (93)
Programming of intermediary metabolism (2001) (91)
The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women. (1989) (90)
Fetal growth and insulin secretion in adult life (1994) (86)
Immunoradiometric assay of parathyroid hormone. (1971) (85)
THE IMMUNORADIOMETRIC ASSAY AND RELATED TECHNIQUES (1974) (85)
Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans. (1996) (84)
Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study. (1998) (84)
Height and glucose tolerance in adult subjects (1991) (83)
PLASMA CONCENTRATIONS OF GLUCOSE, NON-ESTERIFIED FATTY ACID, AND INSULIN DURING ORAL GLUCOSE-TOLERANCE TESTS IN THYROTOXICOSIS. (1964) (82)
Maternal low protein diet in rats programmes fatty acid desaturase activities in the offspring (1998) (78)
The preparation and properties of purified 125-I-labelled antibodies to insulin. (1968) (77)
Labeled antibodies and their use in the immunoradiometric assay. (1980) (76)
Insulin Deficiency Rather Than Hyperinsulinaemia in Newly Diagnosed Type 2 Diabetes Mellitus (1993) (74)
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed Type II diabetes: the Insulin Resistance Atherosclerosis Study (1999) (74)
Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. (1999) (74)
Effect of Intravenous Glucose on Concentration of Insulin in Maternal and Umbilical-cord Plasma (1965) (70)
Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the Controlled Antenatal Thyroid Study. (2014) (70)
Evidence of beta cell dysfunction which does not lead on to diabetes: a study of identical twins of insulin dependent diabetics. (1987) (70)
Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity. (2006) (70)
Reproducibility of the Short Insulin Tolerance Test (1993) (68)
The relation of fetal growth to plasma glucose in young men (1992) (67)
Cigarette smoking is not associated with hyperinsulinemia: evidence against a causal relationship between smoking and insulin resistance. (1996) (66)
LDL particle size in relation to insulin, proinsulin, and insulin sensitivity. The Insulin Resistance Atherosclerosis Study. (1999) (65)
The relationships of concentrations of insulin, intact proinsulin and 32–33 split proinsulin with cardiovascular risk factors in Type 2 (non-insulin-dependent) diabetic subjects (1990) (65)
Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation. (2009) (64)
Fetal and infant growth and impaired glucose tolerance in adulthood: the “thrifty phenotype” hypothesis revisited (1997) (64)
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects (1995) (63)
Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men—report from 27 years of follow-up study (2003) (63)
Interaction of non-esterified fatty acid and insulin in control of triacylglycerol secretion by Hep G2 cells. (1991) (61)
Effects of early protein restriction and adult obesity on rat pancreatic hormone content and glucose tolerance. (2000) (60)
Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men. (2004) (60)
How to measure plasma insulin. (1994) (59)
Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates (2004) (59)
Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels. (2001) (59)
Two variants of quantitative reverse transcriptase PCR used to show differential expression of alpha-, beta- and gamma-fibrinogen genes in rat liver lobes. (1997) (59)
The interaction of various inhibitors and stimuli of insulin release studied with rabbit pancreas in vitro. (1969) (58)
Relation of cord plasma concentrations of proinsulin, 32-33 split proinsulin, insulin and C-peptide to placental weight and the baby's size and proportions at birth. (1996) (57)
Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycle. (2005) (56)
Sensitive Amplified Immunoenzymometric Assays (IEMA) for Human Insulin and Intact Proinsulin (1992) (56)
Effects of maternal iron restriction on placental vascularization in the rat. (2001) (55)
Metabolic consequences of intrauterine growth retardation (1997) (54)
Five new insulin-producing cell lines with differing secretory properties. (1986) (54)
Raised proinsulin concentration as early indicator of beta cell dysfunction. (1991) (53)
Control of Hep G2-cell triacylglycerol and apolipoprotein B synthesis and secretion by polyunsaturated non-esterified fatty acids and insulin. (1992) (52)
Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids (1994) (51)
Exocrine and endocrine pancreatic function in diabetes mellitus and chronic pancreatitis (1966) (51)
Long-term effects on offspring of intrauterine exposure to deficits in nutrition. (2000) (51)
Cations and the secretion of insulin. (1968) (48)
Methods of cellular senescence induction using oxidative stress. (2007) (47)
Fetal growth and hyperinsulinaemia in adult life (1998) (46)
Endocrine pancreas and diabetes: edited by J. Pierluissi, Excerpta Medica, Amsterdam and Oxford, 1979. Dfl. 135.00 (312 pages) ISBN 0 444 90051 9 (1980) (45)
Oral glucose decreases hepatic extraction of insulin. (1983) (43)
Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells (1995) (43)
The action of local anaesthetics on lipolysis and on adenosine 3':5'-cyclic monophosphate content in isolated rat fat-cells. (1974) (43)
The relationship between the concentration of adenosine 3':5'-cyclic monophosphate and the anti-lipolytic action of insulin in isolated rat fat-cells. (1974) (43)
ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis. (1988) (42)
FASTING PLASMA CONCENTRATIONS OF INSULIN, NON-ESTERIFIED FATTY ACIDS, GLYCEROL, AND GLUCOSE IN THE EARLY DETECTION OF DIABETES MELLITUS. (1965) (42)
Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression. (2007) (42)
Insulin and insulin propeptides at birth in offspring of diabetic mothers. (2003) (38)
Early and late nutritional windows for diabetes susceptibility (1997) (38)
Prospective cohort study of the relationship of markers of insulin resistance and secretion with weight gain and changes in regional adiposity (1999) (38)
Ketosis resistance in the male offspring of protein-malnourished rat dams. (1998) (37)
Development of insulin and proinsulin secretion in newborn pony foals. (2004) (37)
The sodium pump and insulin secretion. (1967) (37)
Sugar transport in rat liver lysosomes. Direct demonstration by using labelled sugars. (1983) (37)
Proinsulin and insulin concentrations following intravenous glucose challenges in normal, obese, and non-insulin-dependent diabetic subjects. (1993) (36)
Single channel recordings of potassium currents in an insulin-secreting cell line. (1986) (35)
Postprandial Lipid Metabolism and β‐cell Function in Non‐insulin‐dependent (Type 2) Diabetes Mellitus After a Mixed Meal with a High Fat Content (1996) (35)
Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of Type 1 (insulin-dependent) diabetic patients (1988) (34)
Immunoradiometric assay of human growth hormone. (1968) (33)
Measurement of Proinsulin and Intermediates: Validation of Immunoassay Methods by High-Performance Liquid Chromatography (1995) (33)
Older Australians in hospital (2007) (33)
Nutrition in Pregnancy and the Concentrations of Proinsulin, 32–33 Split Proinsulin, Insulin, and C‐peptide in Cord Plasma (1996) (32)
Effect of adrenaline on 32 P incorporation into rat fat-cell phospholipids. (1972) (31)
Calcium and ATP regulate the activity of a non-selective cation channel in a rat insulinoma cell line (1987) (31)
Control of amylase biosynthesis and release in the parotid gland of the rat. (1978) (31)
Genotype analysis in cystic fibrosis in relation to the occurrence of diabetes mellitus (1993) (31)
Effect of Sulphonylurea Therapy on Plasma Insulin, Intact and 32/33 Split Proinsulin in Subjects with Type 2 Diabetes Mellitus (1994) (30)
PROINSULIN IN HUMAN SERUM: PROBLEMS IN MEASUREMENT AND INTERPRETATION (1984) (30)
Characterization and Use in Immunoradiometric Assay of Monoclonal Antibodies Directed Against Human Proinsulin (1987) (30)
The effect of insulin on 32Pi incorporation into rat fat cell phospholipids. (1974) (30)
Observations on the lipolytic activity of human serum and pituitary fractions in vitro. (1967) (30)
Effects of protein restriction in early life on growth and function of the gastrointestinal tract of the rat. (1998) (30)
Adult BMI and fat distribution but not height amplify the effect of low birthweight on insulin resistance and increased blood pressure in 20-year-old South Africans (2005) (29)
Rates of effux and intracellular concentrations of potassium, sodium and chloride ions in isolated fat-cells from the rat. (1969) (28)
Fetal and infant growth and impaired glucose tolerance: Authors' reply (1991) (28)
Maintenance of viable cells in an organ culture of mature rat liver. (1971) (28)
Factors affecting the permeability of isolated fat-cells from the rat to [42K] potassium and [36Cl] chloride ions. (1970) (26)
Ca2+—calmodulin dependent myosin light‐chain phosphorylating activity in insulin‐secreting tissues (1982) (26)
Normal Proinsulin Responses to Glucose in Mild Type II Subjects With Subnormal Insulin Response (1993) (26)
Thrifty yes, genetic no (1998) (26)
Fetal Growth and Insulin Resistance in Adult Life: Role of Plasma Triglyceride and Non‐esterified Fatty Acids (1995) (26)
Plasma insulin in pancreatic disease (1970) (25)
Hypertension and its treatment influence changes in fasting nonesterified fatty acid concentrations: a link between the sympathetic nervous system and the metabolic syndrome? (2000) (25)
Mg2+‐dependent inhibition of KATP by sulphonylureas in CRI‐G1 insulin‐secreting cells (1994) (25)
A rapid immunological procedure for the isolation of hormonally sensitive rat fat-cell plasma membrane. (1976) (25)
The pathogenesis of NIDDM (1994) (24)
Localization of calcium in the smooth endoplasmic reticulum of rat isolated fat cells. (1974) (24)
Improved Beta Cell Function, with Reduction in Secretion of Intact and 32/33 Split Proinsulin, after Dietary Intervention in Subjects with Type 2 Diabetes Mellitus (1994) (24)
Suicide of the nephron (2001) (24)
Use of specific immunoradiometric assay to determine preterm neonatal insulin-glucose relations. (1995) (24)
Regulation of lipolysis in isolated human adipose-tissue cells. (1966) (23)
The effects of trypsin on ATP-sensitive potassium channel properties and sulfonylurea receptors in the CRI-G1 insulin-secreting cell line. (1994) (23)
The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol (2014) (23)
The permeability of rat liver lysosomes to sugars. Evidence for carrier-mediated facilitated diffusion. (1979) (22)
Pre- and early postnatal nongenetic determinants of type 2 diabetes (2002) (22)
Dissociation of the effect of adrenalin on glucose uptake from that on adenosine cyclic 3',5'-monophosphate levels and on lipolysis in rat-isolated fat cells. (1974) (22)
Complement-induced Ca2+ influx in cultured fibroblasts is decreased by the calcium-channel antagonist nifedipine or by some bivalent inorganic cations. (1993) (22)
Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. (1984) (22)
Fetal and infant origins of adult disease. (1997) (21)
The Relation of Fetal Growth to Insulin Secretion in Young Men (1996) (21)
The inhibition of rat liver glucokinase by palmitoyl-CoA. (1969) (21)
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11 (1993) (21)
The Effect of Maternal Body Condition Score Before and During Pregnancy on the Glucose Tolerance of Adult Sheep Offspring (2008) (20)
IONIC MECHANISMS IN THE REGULATION OF INSULIN SECRETION (1970) (19)
Isolation and characterization of calmodulin from an insulin-secreting tumour. (1981) (19)
The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide. (1996) (18)
The effect of hypophysectomy on rat liver glucokinase activity and on plasma glucose, insulin and nonesterified fatty acid concentrations. (1969) (17)
Insulin secretion by a transplantable rat islet cell tumour (1981) (17)
Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance (1995) (17)
K-channels in an insulin-secreting cell line: effects of ATP and sulphonylureas. (1986) (15)
Insulin deficiency and increased intact and 32/33 split proinsulin secretion following human islet autotransplantation. (1998) (15)
Immunoradiometric assay of insulin, intact proinsulin and 32–33 split proinsulin and radioimmunoassay of insulin in diet-treated Type 2 (non-insulin-dependent) diabetic subjects (1992) (15)
Two site assay of human growth hormone. (1971) (15)
A common apolipoprotein B signal peptide polymorphism modifies the relation between plasma non-esterified fatty acids and triglyceride concentration in men. (2000) (15)
Suckling a protein-restricted rat dam leads to diminished albuminuria in her male offspring in adult life: a longitudinal study (2006) (15)
Blood-glucose, plasma-insulin and growth hormone concentrations of individuals with minor abnormalities of glucose tolerance (1968) (14)
Pancreatic B-cells secrete a range of novel peptides besides insulin. (1984) (14)
Plasma proinsulin in first-degree relatives of type 2 diabetic subjects. (1990) (14)
Insulin resistance and impaired glucose tolerance (1994) (13)
The effects of human proinsulin on glucose turnover and intermediary metabolism. (1991) (13)
Is an exaggerated postprandial triglyceride response associated with the component features of the insulin resistance syndrome? (1997) (13)
Effects of chemical modification of amino and sulfhydryl groups on KATP channel function and sulfonylurea binding in CRI-G1 insulin-secreting cells (1994) (13)
The role of insulin in the regulation of glucose metabolism (1971) (12)
Analysis of expression of growth factor receptors in replicatively and oxidatively senescent human fibroblasts (2005) (12)
Plasma-levels of glucose, non-esterified fatty acid, glycerol, and insulin four years before the onset of diabetic ketosis. (1967) (12)
Pharmacokinetics of biosynthetic human proinsulin following intravenous and subcutaneous administration in metabolically healthy volunteers. (1988) (11)
Two variants of quantitative reverse transcriptase PCR used to show differential expression of a -, b - and c -ﬁbrinogen genes in rat liver lobes (1997) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution. (2007) (10)
Measurement of human proinsulin by an indirect two-site immunoradiometric assay (2005) (10)
Kinetics of biosynthetic human proinsulin in patients with terminal renal insufficiency. (1988) (10)
Calcium as a Mediator of Hormone Action (1977) (10)
The effects of Mg2+, Ca2+, ATP and cyclic 3',5'-AMP on the hormone-sensitive lipase of adipose tissue. (1970) (10)
The first phase insulin response to intravenous glucose is highly reproducible (1990) (10)
Plasma insulin in minor abnormalities of glucose tolerance: a 5 year follow-up (1974) (10)
Nucleotide regulation of a calcium-activated cation channel in the rat insulinoma cell line, CRI-G1 (1994) (10)
Early growth restriction, membrane phospholipid fatty acid composition, and insulin sensitivity. (2001) (10)
IMMUNORADIOMETRIC ASSAY PROCEDURES: NEW DEVELOPMENTS. (1970) (10)
Lipolytic activity of human pituitary fractions on isolated human adipose-tissue cells. (1966) (9)
Normal proinsulin processing despite beta-cell dysfunction in persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis) (1996) (9)
The effect of bivalent cation chelating agents on some actions of adrenalin and insulin in rat isolated fat cells. (1980) (9)
Role of insulin and proinsulin in diabetic vascular disease. (1995) (9)
Nucleotide-sensitive ion channels in human insulin producing tumour cells (1987) (9)
The glucose–fatty acid cycle and the aetiology of diabetes (1966) (9)
Ciclazindol inhibits ATP-sensitive K+ channels and stimulates insulin secretion in CR1-G1 insulin-secreting cells. (1996) (8)
Epitope analysis of human insulin and intact proinsulin. (1994) (8)
The effect of insulin on delta5 desaturation in hepG2 human hepatoma cells and L6 rat muscle myoblasts. (1999) (8)
Identification of a novel complement-dependent serum-elicited inward current in the Xenopus oocyte provoking Ca2+ influx and subsequent activation of Cl- channels. (1999) (8)
Cyclic AMP regulates a calcium-activated non-selective cation channel in a rat insulinoma cell line (1992) (8)
Post-receptor insulin resistance after diazoxide in non-insulin dependent diabetes. (1986) (7)
Bioassay of glucagon in human serum. (1970) (7)
Effect of ethanol on hepatic apolipoprotein B synthesis and secretion in vitro. (1994) (7)
The effects of ions and pH on the transport of sugars into rat liver lysosomes (1979) (7)
Early programming of glucose metabolism, insulin action and longevity. (2000) (7)
Immunoradiometric and two-site assay of human follicle-stimulating hormone. (1973) (7)
Mg(2+)-dependent inhibition of KATP by sulphonylureas in CRI-G1 insulin-secreting cells. (1994) (7)
Difficulties in localization and treatment of insulinomas in type 1 multiple endocrine adenomatosis (MEA). (1992) (7)
Lipolytic activity of human pituitary fractions on human adipose tissue cells. (1972) (7)
Effect of pancreas transplantation and immunosuppression on proinsulin secretion (1998) (6)
Impaired glucose tolerance and height. (1991) (6)
Proinsulin and Its Conversion Intermediates in Human Pancreas and Isolated Islet Tissue: Kinetics and Steady‐State Analysis (1997) (6)
Permeability properties of lysosomal membranes (1983) (6)
Immunological Isolation of Rat Fat-Cell Plasma Membranes (1974) (6)
SPONTANEOUS HYPOGLYCAEMIA AND SARCOMA (1965) (6)
The effect of local anaesthetics on lipolysis in fat-cells. (1972) (6)
The mechanism of insulin secretion studied through the effects of electrolytes and inhibitors. (1970) (6)
Hormonal control of adipose tissue lipolysis. (1975) (6)
Dose-response characteristics of human proinsulin and insulin in non-insulin-dependent diabetic humans. (1992) (5)
Temporal relationship of insulin, intact proinsulin and split proinsulin after islet autotransplantation. (2001) (5)
Indirect two-site immunoradiometric assay of rat and mouse proinsulin (2005) (5)
The relationship of some rat liver glycolytic enzyme activities to plasma insulin concentration. (1968) (5)
Calcium as a mediator of hormone action [proceedings]. (1977) (5)
The role of ions in the hormonal control of adipose tissue. (1970) (5)
Early malnutrition and programming of adult degenerative diseases: experimental, epidemiological and preventive studies. (2001) (5)
Calcium and lipolysis in adipose tissue: effects of ethanedioxybis-(ethylamine)tetra-acetate (EGTA) and ionophore A23187 [proceedings]. (1977) (5)
Glucose suppresses ATP-inhibited K-channels in pancreatic beta-cells. (1986) (5)
The role of insulin and proinsulin in the regulation of triglyceride metabolism. (2009) (5)
Regulation of calcium-activated nonselective cation channel activity by cyclic nucleotides in the rat insulinoma cell line, CRI-G1 (1995) (4)
Reply to Comment on: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure (2004) (4)
The effects of pyridine nucleotides on the activity of a calcium-activated nonselective cation channel in the rat insulinoma cell line, CRI-G1 (1994) (4)
Abnormal control of the metabolism of non-esterified fatty acid in obesity. (1966) (4)
Glucokinase deficiency results in a beta-cell disorder characterised by normal fasting plasma proinsulin concentrations (1997) (4)
Micromodification of an Immunoradiometric Assay for Proinsulin (1980) (4)
Evidence for facilitated diffusion of sugars in rat liver lysosomes [proceedings]. (1979) (4)
The Effect of Glibenclamide Administration on Insulin Sensitivity and Insulin Binding to Monocytes in Normal Subjects (1985) (4)
EFFECT OF DIET AND DIABETES ON PLASMA GLUCOSE, FATTY ACID, AND INSULIN (1963) (4)
Sugar transport in lysosomes? (1982) (4)
[Ion fluxes and membrane function in beta-cells and adipocytes]. (1970) (4)
Some actions of hormones in the regulation of glucose metabolism. (1967) (3)
Incorporation of radioactive folic acid into liver folate. (1972) (3)
Lysosomes and prohormone activation (1985) (3)
Substrate mobilization and energy provision in man (1978) (3)
Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. (1997) (3)
British Diabetic Association Abstracts Medical and Scientific Section, Spring Meeting (1968) (3)
Voltage-activated currents in the CRI-G1 rat insulin-secreting cell-line. (1991) (3)
The effects of subcutaneous human proinsulin on the production of 64/65 split proinsulin, glucose turnover and intermediary metabolism in non-insulin-dependent diabetic man. (1993) (3)
Immunological techniques in diabetes research: 14 years on (1985) (2)
Radioimmunoassay and saturation analysis. The immunoradiometric assay and related techniques. (1974) (2)
The role of the intrauterine environment in the later development of type 2 diabetes and the metabolic syndrome (2001) (2)
The electron microscopic localization of cations to pancreatic islets of Langerhans and their possible tole in insulin secretion. (1973) (2)
Glucocorticoids stimulate the division of rat pancreatic islet tumour cells in tissue culture (1984) (2)
Immunological techniques in diabetes research (1972) (2)
Plasma insulin inpancreatic disease (1970) (2)
Action profile of biosynthetic human proinsulin trials with the BIOSTATOR in metabolically normal subjects. (1988) (2)
The role of poor fetal and infant growth in non-insulin-dependent diabetes. (1993) (2)
DIAZOXIDE, GLIPIZIDE, AND HYPOGLYCÆMIA (1977) (2)
Ferritin estimation by a radioimmunoassay technique: serum levels in normal subjects and patients with blood disorders. (1972) (2)
Perspectives in Diabetes ATP-Sensitive K + Channels in Pancreatic P-Cells Spare-Channel Hypothesis (1988) (2)
MATURITY-ONSET DIABETES OF THE YOUNG IS A BETA-CELL DISORDER WITH NORMAL PROINSULIN LEVELS (1993) (2)
INSULIN RESISTANCE IN 7 YEAR OLD CHILDREN WHO WERE THIN AT BIRTH (1994) (2)
The effect of biosynthetic human proinsulin on intermediary metabolism (1987) (2)
Charles Herbert Best, 27 February 1899 - 31 March 1978 (1982) (1)
Hormonal Disturbances in Diabetes (1968) (1)
The accumulation of sugars in lysosomes from liver, muscle and fat-cells [proceedings]. (1980) (1)
Immunoradiometric assay of polypeptide hormones. (1969) (1)
Lysosomal sugar transport: facilitated or free diffusion? (1988) (1)
Determination of proinsulin intermediates by means of an immunoradiometric method using polyclonal antibodies. (1988) (1)
Lipolysis in chicken adipose tissue: a correction. (1969) (1)
Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Cellular Processes (1985) (1)
Use of sodium measurement as a surrogate volume measurement in unmetered-blood collection devices. (2002) (1)
The effects of human proinsulin on glucose turnover and intermediary metabolism in insulin-dependent-diabetes mellitus. (1992) (1)
British Diabetic Association Abstracts (1968) (1)
Non-Esterified Fatty Acids and Insulin Sensitivity in Hypothalamichyperphagic Rats [Abridged] (1964) (1)
The use of labelled antibodies in the assay of polypeptide hormones. (1969) (1)
UK clinical research (1992) (1)
etal Growth and Adult Diseases usan (2004) (1)
Immunological methods in endocrinology : symposium in Ulm, February 25, 1970 in connection with the 16th symposium of the German Endocrine Society (1971) (1)
Fetal and early childhood environment : long-term health implications Most diabetes (2005) (0)
Symposium Report The dangerous road of catch-up growth (2003) (0)
Organization section (2005) (0)
Effects of dysmaturity on pancreatic βcell function in newborn foals (2005) (0)
Immunological Techniques and the Assay of Human Pituitary Glycoprotein Hormones (1974) (0)
British Diabetic Association Medical and Scientific Section, Autumn Meeting Abstracts (1967) (0)
Human hormones in health and disease (1977) (0)
Perinatal detection of programming of hepatic metabolism in offspring of mothers exposed to a low protein diet during pregnancy 70 (1996) (0)
Identification of Ca2+-calmodulin dependent enzyme activities in an insulin-secreting tumour (1982) (0)
Intact Proinsulin and Proinsulin Split Products Play a Major Part in the Regulation of Blood Pressure in non-Insulin Dependent Diabetics (1989) (0)
Elevated Concentrations of Intact Proinsulin and 32–33 Split Proinsulin in non-Obese Subjects with Impaired Glucose Tolerance (1991) (0)
[From the economic genotype to the economic phenotype]. (2005) (0)
93 THE USE OF A SPECIFIC IMMUNORADIOMETRIC ASSAY (IRMA) TO DETERMINE NEONATAL INSULIN-GLUCOSE RELATIONSHIPS (1994) (0)
Molecular and Cellular Biology of Diabetes Mellitus (1990) (0)
Ionic effects on the transport of sugars in rat liver lysosomes [proceedings]. (1979) (0)
Use of terminology related to fetal insulin secretion (2006) (0)
The effect of adrenaline and of alpha- and beta- adrenergic blocking agents on 32P incorporation into fat-cell phospholipids. (1971) (0)
THE IMMUNOLOGICAL ASSAY OF INSULIN USING AN ANTISERUM TO HUMAN INSULIN (1966) (0)
Infant nutrition and subsequent risk of Type 2 (non-insulin-dependent) diabetes mellitus (1993) (0)
Immunoradiometric assay of human proinsulin and partially processed proinsulin with use of monoclonal antibody and streptavidin-biotin labeling. (1989) (0)
UK clinical research (1991) (0)
lin . Proinsulin is increased relative to insulin in subjects with type 2 diabetes in all studies (1998) (0)
Ca 2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat #-cell tumour (2005) (0)
Assessment of proinsulin's effects on intermediary metabolism using the forearm technique in normal man (2004) (0)
Proceedings: Immunological techniques and assay of human pituitary glycoprotein hormones. (1974) (0)
Spontaneous hypoglycaemia and sarcoma. A case report. (1965) (0)
Hyperinsulinism (1969) (0)
Principles and Practice of Radio-Immunoassay (1967) (0)
Interrelationship of Plasma Free Fatty Acids and Blood Beta-Hydroxybutyrate Concentration in Coronary Artery Disease (1974) (0)
The Permeability of Rat Liver Lysosomes (2005) (0)
The Glucose Fatty Acid Cycle and Diabetes Mellitus (2008) (0)
CALMODULIN AND CALMODULIN-BINDING PROTEINS IN AN INSULIN SECRETING TUMOUR (1981) (0)
Plasma-insulin in diabetes. (2008) (0)
Thyroid hormone increases hepatic apolipoprotein-B synthesis (1995) (0)
Academic medicine and the new consultant contract (1977) (0)
Intrauterine growth and serum cholesterol: Authors' reply (1994) (0)
Insulin in vivo increases the in vitro fall of plasma potassium concentration in human venous blood (1985) (0)
Abstracts from the twenty-third meeting of the pancreatic society of Great Britain and Ireland at the Village Hotel, Leeds, UK (1999) (0)
Response from the authors (2006) (0)
6D-5 Programming of hypothalamic neuropeptide gene expression in rats by early life nutrition (2007) (0)
Postnatal and Adult Insulin Sensitivity and Metabolism in Progeny of Nutritionally Compromised Mothers (2002) (0)
THE PERMEABILITY OF LYSOSOMES TO SUGARS (1981) (0)
NON-ESTERIFIED FATTY ACIDS AND INSULIN SENSITIVITY IN HYPOTHALAMIC-HYPERPHAGIC RATS. (1964) (0)
British Diabetic Association Medical and Scientific Section, Spring Meeting Abstracts (1967) (0)
Pancreatic B Cell Function in Motor Neurone Disease (1992) (0)
Principles and modifications of radioimmunological assays of protein hormones. (1971) (0)
Association between serum concentrations of advanced glycation end products and C-reactive protein in type 2 diabetes mellitus (2003) (0)
Postprandial b-cell secretion of insulin procursors in NIDDM in response to a mixed meal with a high fat content (1995) (0)
GENERAL COMPARISON OF THE PROPERTIES OF POLYPEPTIDE HORMONE AND LYSOSOMAL SYSTEMS (1981) (0)
Inhibition of CXCR4 Activity Attenuates Development of Pulmonary Hypertension and Vascular Remodeling Induced by Hypoxia in Rats. (2009) (0)
Essays in medical biochemistry (1975) (0)
Insulin resistance and impaired glucose tolerance. (1994) (0)

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