Chi-Chao Chan
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American ophthalmologist
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Philosophy
Chi-Chao Chan's Degrees
- Doctorate Medicine University of California, San Francisco
- PhD Biochemistry University of California, San Francisco
Why Is Chi-Chao Chan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Chi-Chao Chan is a Chinese-born American ophthalmologist and physician-scientist specialized in the diagnosis and pathology of eye diseases. She joined the National Eye Institute as a postdoctoral researcher in 1982 and remained until her retirement in 2015. Chan was promoted in 1999 to senior investigator and chief of the NEI immunopathology section and the histopathology core.
Chi-Chao Chan's Published Works
Published Works
- Tumor-specific Th17-polarized cells eradicate large established melanoma. (2008) (795)
- Seven New Loci Associated with Age-Related Macular Degeneration (2013) (741)
- CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005) (735)
- Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category (2008) (708)
- The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. (2012) (565)
- Molecular pathology of age-related macular degeneration (2009) (540)
- CENTRAL RETINAL VEIN OCCLUSION: A Prospective Histopathologic Study of 29 Eyes in 28 Cases (2005) (471)
- Th17 cells are long lived and retain a stem cell-like molecular signature. (2011) (402)
- Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye. (2002) (342)
- Rapamycin slows aging in mice (2012) (338)
- Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. (2011) (334)
- Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response 1 (2009) (330)
- Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. (2015) (293)
- Serum inflammatory markers in diabetic retinopathy. (2005) (279)
- Interleukin 12 Protects from a T Helper Type 1–mediated Autoimmune Disease, Experimental Autoimmune Uveitis, through a Mechanism Involving Interferon γ, Nitric Oxide, and Apoptosis (1999) (226)
- The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age‐related macular degeneration (2004) (221)
- Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. (2007) (206)
- Noncanonical Autophagy Promotes the Visual Cycle (2013) (190)
- Aging is not a disease: Distinguishing age-related macular degeneration from aging (2013) (190)
- Ocular and central nervous system lymphoma: clinical features and diagnosis (2000) (183)
- IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma. (2007) (181)
- Macrophage polarization in the maculae of age‐related macular degeneration: A pilot study (2011) (176)
- Intraocular lymphoma: update on diagnosis and management. (2004) (175)
- Immunopathological aspects of age-related macular degeneration (2008) (164)
- Blood‐retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: Comparison with vascular endothelial growth factor, tumor necrosis factor α, and interleukin‐1β‐mediated breakdown (1997) (161)
- Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis. (2004) (160)
- Essential Role of the MyD88 Pathway, but Nonessential Roles of TLRs 2, 4, and 9, in the Adjuvant Effect Promoting Th1-Mediated Autoimmunity (2005) (155)
- Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. (2012) (155)
- Age-related macular degeneration (2008) (153)
- Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration (2011) (150)
- Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation (2002) (149)
- Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. (2012) (146)
- Analysis of Glomerulosclerosis and Atherosclerosis in Lecithin Cholesterol Acyltransferase-deficient Mice* (2001) (140)
- Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity (2008) (132)
- Molecular pathology of primary intraocular lymphoma. (2004) (131)
- Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma (1999) (129)
- Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration. (2003) (124)
- Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II‐B heavy chain (2001) (123)
- Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) (121)
- Noncanonical Autophagy Promotes the Visual Cycle (2013) (118)
- Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. (2006) (117)
- Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels. (2003) (115)
- Toxoplasma gondii: Acquired Ocular Toxoplasmosis in the Murine Model, Protective Role of TNF-α and IFN-γ (1994) (111)
- Autoimmune and autoinflammatory mechanisms in uveitis (2014) (110)
- Autoimmune Uveitis Elicited with Antigen-Pulsed Dendritic Cells Has a Distinct Clinical Signature and Is Driven by Unique Effector Mechanisms: Initial Encounter with Autoantigen Defines Disease Phenotype1 (2007) (107)
- The role of infectious agents in the etiology of ocular adnexal neoplasia. (2008) (105)
- Choroideremia: new findings from ocular pathology and review of recent literature. (2009) (104)
- Mouse Models of Experimental Autoimmune Uveitis (2008) (100)
- A Double-masked, Randomized Study to Investigate the Safety and Efficacy of Daclizumab to Treat the Ocular Complications Related to Behçet's Disease (2007) (99)
- Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma. (2003) (98)
- Genetic factors of age-related macular degeneration (2004) (98)
- Diagnosis and management of primary intraocular lymphoma. (2005) (96)
- Mutations in KCNJ13 cause autosomal-dominant snowflake vitreoretinal degeneration. (2008) (96)
- Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model: Concomitant regulation by MHC and non-MHC genes (1991) (96)
- Gene therapy for ocular diseases (2010) (95)
- MCP-1 expression in endotoxin-induced uveitis. (2002) (95)
- CLINICOPATHOLOGIC CORRELATION OF THE MULTIPLE RECURRENT SEROSANGUINEOUS RETINAL PIGMENT EPITHELIAL DETACHMENTS SYNDROME (1994) (94)
- Biopsy techniques and yields in diagnosing primary intraocular lymphoma (2007) (94)
- Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. (2013) (94)
- A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. (2003) (93)
- Ccl2/Cx3cr1-Deficient Mice: An Animal Model for Age-Related Macular Degeneration (2008) (92)
- Ocular manifestations of central nervous system lymphoma (2001) (91)
- T cell mechanisms in experimental autoimmune uveoretinitis: Susceptibility is a function of the cytokine response profile (1997) (89)
- The pharmacokinetics of rituximab following an intravitreal injection. (2006) (88)
- Regulation of Ocular Inflammation — What Experimental and Human Studies have Taught Us (2001) (88)
- Molecular Biomarkers for the Diagnosis of Primary Vitreoretinal Lymphoma (2011) (86)
- Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity (2006) (86)
- An Immunologically Privileged Retinal Antigen Elicits Tolerance (2003) (84)
- Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. (2013) (83)
- Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities1 (2008) (82)
- Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology. (2004) (81)
- Sympathetic ophthalmia: to the twenty-first century and beyond (2013) (81)
- Genetics of Immunological and Inflammatory Components in Age-related Macular Degeneration (2012) (79)
- Clinical and Immunohistologic Studies of Corneal Rejection in the Rat Penetrating Keratoplasty Model (1991) (79)
- Vitreous cytokine levels. (2003) (77)
- Ophthalmic manifestations and histopathology of infantile nephropathic cystinosis: report of a case and review of the literature. (2007) (77)
- Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune uveoretinitis (1993) (75)
- A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. (2009) (74)
- Pathophysiology of Retinal Lymphoma (2009) (74)
- The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. (2007) (74)
- Activation of Invariant NKT Cells Ameliorates Experimental Ocular Autoimmunity by A Mechanism Involving Innate IFN-γ Production and Dampening of the Adaptive Th1 and Th17 Responses1 (2008) (74)
- Prediction of myopia development among Chinese school-aged children using refraction data from electronic medical records: A retrospective, multicentre machine learning study (2018) (73)
- FLUORESCEIN ANGIOGRAPHIC FINDINGS IN PRIMARY INTRAOCULAR LYMPHOMA (2002) (72)
- The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration. A population-based case-control study. (2008) (71)
- The Effect of Quercetin in Cultured Human RPE Cells under Oxidative Stress and in Ccl2/Cx3cr1 Double Deficient Mice (2010) (71)
- Ocular manifestations of xeroderma pigmentosum: long-term follow-up highlights the role of DNA repair in protection from sun damage. (2013) (71)
- A unique pattern of up‐ and down‐regulation of chemokine receptor CXCR3 on inflammation‐inducing Th1 cells (2004) (70)
- MOLECULAR PATHOLOGY OF EYES WITH VON HIPPEL–LINDAU (VHL) DISEASE: A Review (2007) (70)
- Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics (2012) (69)
- EXPERIMENTAL AUTOIMMUNE UVEITIDES: MULTIPLE ANTIGENS, DIVERSE DISEASES (2002) (69)
- Viral Retinitis following Intraocular or Periocular Corticosteroid Administration: A Case Series and Comprehensive Review of the Literature (2014) (68)
- Human T-cell lymphotropic virus type-1 associated t-cell leukemia/lymphoma masquerading as necrotizing retinal vasculitis. (2002) (67)
- Survival of donor epithelial cells after limbal stem cell transplantation. (2005) (65)
- Retina-Specific T Regulatory Cells Bring About Resolution and Maintain Remission of Autoimmune Uveitis (2015) (65)
- Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist (2010) (64)
- Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples. (2009) (63)
- Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration. (2008) (63)
- An apolipoprotein E variant may protect against age‐related macular degeneration through cytokine regulation (2006) (63)
- The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24 (2020) (62)
- Inflammatory Mechanisms of Age-related Macular Degeneration (2015) (61)
- The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. (2008) (60)
- NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration (2016) (60)
- Consensus on the Diagnosis and Management of Nonparaneoplastic Autoimmune Retinopathy Using a Modified Delphi Approach. (2016) (58)
- Subretinal fibrosis and choroidal neovascularization in Vogt-Koyanagi-Harada syndrome (1999) (58)
- Human HtrA1 in the archived eyes with age-related macular degeneration. (2007) (57)
- Ophthalmic manifestations and histopathology of xeroderma pigmentosum: two clinicopathological cases and a review of the literature. (2011) (57)
- Autoreactive Memory CD4+ T Lymphocytes That Mediate Chronic Uveitis Reside in the Bone Marrow through STAT3-Dependent Mechanisms (2011) (57)
- Genetic markers and biomarkers for age-related macular degeneration (2007) (56)
- IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. (2014) (56)
- Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. (2007) (55)
- FUNDUS AUTOFLUORESCENCE PATTERNS IN PRIMARY INTRAOCULAR LYMPHOMA (2011) (55)
- Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration. (2014) (55)
- Induction of ocular inflammation by T-helper lymphocytes type 2. (2002) (54)
- Immune mechanisms in choroido-retinal inflammation in man (1990) (53)
- Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. (2013) (53)
- Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice. (2009) (52)
- Mouse models of MYH 9-related disease : mutations in nonmuscle myosin IIA (2011) (52)
- Pertussis Toxin Is Superior to TLR Ligands in Enhancing Pathogenic Autoimmunity, Targeted at a Neo-Self Antigen, by Triggering Robust Expansion of Th1 Cells and Their Cytokine Production1 (2006) (52)
- Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types. (2004) (52)
- Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis (2013) (51)
- Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation. (2011) (50)
- A progressive anterior fibrosis syndrome in patients with postsurgical congenital aniridia. (2005) (50)
- Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis (2000) (50)
- Suppression of immune-mediated ocular inflammation in mice by interleukin 1 receptor antagonist administration. (2005) (50)
- Comparative Analysis of Induced vs. Spontaneous Models of Autoimmune Uveitis Targeting the Interphotoreceptor Retinoid Binding Protein (2013) (50)
- Noninvasive diagnosis and ophthalmic features of mucolipidosis type IV. (2002) (49)
- Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration (2013) (49)
- Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma: report of a case and review of the literature. (2008) (49)
- Pertussis Toxin Inhibits Induction of Tissue-Specific Autoimmune Disease by Disrupting G Protein-Coupled Signals (2001) (49)
- Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (2006) (48)
- Paraneoplastic vitelliform retinopathy: clinicopathologic correlation and review of the literature. (2012) (47)
- Fas and Fas Ligand Expressed on Cells of the Immune System, not on the Target Tissue, Control Induction of Experimental Autoimmune Uveitis (2000) (47)
- Tarsal-conjunctival disease associated with Wegener's granulomatosis. (2003) (47)
- Detection of Toxoplasma Gondii DNA in Primary Intraocular B-Cell Lymphoma (2001) (46)
- X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. (2005) (45)
- Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. (2011) (45)
- Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation. (2014) (44)
- Neuroanatomy of the extraocular muscle tendon enthesis in macaque, normal human, and patients with congenital nystagmus. (2002) (44)
- Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis (2000) (44)
- Intraocular lymphoma (2002) (44)
- Differential modulation of allergic eye disease by chronic and acute ascaris infection. (2005) (44)
- Neoplastic masquerade syndromes in patients with uveitis. (2014) (43)
- Diagnosis of systemic metastatic retinal lymphoma (2011) (43)
- Detection of Helicobacter pylori and Chlamydia pneumoniae genes in primary orbital lymphoma. (2006) (42)
- Distinct microRNA-155 expression in the vitreous of patients with primary vitreoretinal lymphoma and uveitis. (2014) (42)
- Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration (2008) (41)
- Waldenström's macroglobulinemia-associated retinopathy. (2004) (41)
- Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers. (2008) (40)
- Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations (2015) (40)
- ZIKA virus infection causes persistent chorioretinal lesions (2018) (40)
- International Central Nervous System and Ocular Lymphoma Workshop: Recommendations for the Future (2006) (40)
- Anti-la antibody diminishes ocular inflammation in experimental autoimmune uveitis (1988) (39)
- Hydrodynamic Vaccination with DNA Encoding an Immunologically Privileged Retinal Antigen Protects from Autoimmunity through Induction of Regulatory T Cells1 (2007) (39)
- Disruption of CD40/CD40-Ligand Interactions in a Retinal Autoimmunity Model Results in Protection without Tolerance (2005) (39)
- Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model (2014) (39)
- Gut microbiota as a source of a surrogate antigen that triggers autoimmunity in an immune privileged site (2017) (39)
- Copolymer 1 inhibits experimental autoimmune uveoretinitis (2000) (39)
- Ocular involvement in nasal natural killer T-cell lymphoma (2009) (39)
- Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. (2005) (38)
- Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice. (2008) (37)
- Myeloid suppressor cells induced by retinal pigment epithelial cells inhibit autoreactive T-cell responses that lead to experimental autoimmune uveitis. (2012) (37)
- OCULAR TOXOPLASMOSIS IN THE FETUS: Immunohistochemistry Analysis and DNA Amplification (1994) (37)
- Primary intraocular lymphoma. (2007) (37)
- Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease. (2007) (37)
- Resting CD8 T cells recognize β‐galactosidase expressed in the immune‐privileged retina and mediate autoimmune disease when activated (2003) (37)
- Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity (2002) (37)
- Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors. (2004) (36)
- Murine model of primary intraocular lymphoma. (2005) (35)
- Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress (2012) (35)
- Peroxisome Proliferator-Activated Receptor Expression in Murine Models and Humans with Age-related Macular Degeneration. (2009) (35)
- Expression of Cell Adhesion Molecules in Corneal Graft Failure (1993) (35)
- Epigenetics in Ocular Diseases (2013) (35)
- Wnt signaling in age-related macular degeneration: human macular tissue and mouse model (2015) (34)
- Interleukin-17 Retinotoxicity Is Prevented by Gene Transfer of a Soluble Interleukin-17 Receptor Acting as a Cytokine Blocker: Implications for Age-Related Macular Degeneration (2014) (34)
- Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model (2012) (34)
- Massive vascular endothelium growth factor (VEGF) expression in Eales' disease. (2002) (33)
- Involvement of Apoptosis and Interferon-γ in Murine Toxoplasmosis (2001) (33)
- Pathology of Macular Foveoschisis Associated with Degenerative Myopia (2010) (33)
- Retinal vascular proliferation as an ocular manifestation of von Hippel-Lindau disease. (2008) (33)
- Primary testicular and intraocular lymphomas: two case reports and a review of the literature. (2006) (33)
- RPE65 is highly uveitogenic in rats. (2002) (33)
- Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function (2016) (33)
- Tattoo-associated uveitis. (2015) (32)
- Analysis of ocular hypopigmentation in Rab38cht/cht mice. (2007) (32)
- Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: ciliary body medulloepithelioma. (2005) (32)
- Intravenous rituximab for the treatment of cancer-associated retinopathy. (2013) (32)
- Retinal Anatomy and Pathology. (2016) (32)
- Myocilin Mediates Myelination in the Peripheral Nervous System through ErbB2/3 Signaling* (2013) (32)
- Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. (2009) (31)
- Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis. (2009) (31)
- Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs. (2003) (31)
- Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration. (2014) (31)
- Evidence for Enhanced Tissue Factor Expression in Age-related Macular Degeneration (2010) (31)
- Uveitis-Associated Epitopes of Retinal Antigens Are Pathogenic in the Humanized Mouse Model of Uveitis and Identify Autoaggressive T Cells (2011) (30)
- Exacerbation of Retinal Degeneration and Choroidal Neovascularization Induced by Subretinal Injection of Matrigel in CCL2/MCP-1-Deficient Mice (2006) (30)
- Unfolding the therapeutic potential of chemical chaperones for age-related macular degeneration (2008) (30)
- Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouse. (2011) (30)
- Human cytomegalovirus induced cyclooxygenase-2 in human retinal pigment epithelial cells augments viral replication through a prostaglandin pathway. (2006) (30)
- LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells. (2009) (29)
- Loss of heterozygosity for the NF2 gene in retinal and optic nerve lesions of patients with neurofibromatosis 2 (2002) (29)
- Intravitreal Methotrexate Resistance in a Patient with Primary Intraocular Lymphoma (2008) (28)
- Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes. (2003) (28)
- A variant of the Cockayne syndrome B gene ERCC6 confers risk of lung cancer (2008) (28)
- Gender Differences in Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia (2014) (28)
- Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis (2010) (28)
- Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis (2016) (28)
- Primary intraocular lymphoma: clinical features, diagnosis, and treatment. (2003) (28)
- Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue lymphoma. (2006) (28)
- Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1 (2010) (28)
- 25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma (2010) (28)
- Polymerase Chain Reaction in the Diagnosis of Uveitis (2005) (28)
- Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome (2017) (28)
- Ocular manifestations of trichothiodystrophy. (2011) (27)
- Copy number variations in candidate genes in neovascular age-related macular degeneration. (2011) (27)
- Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter. (2004) (27)
- Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype. (2015) (27)
- Cytokine‐dependent Modulation of Oral Tolerance in a Murine Model of Autoimmune Uveitis (1996) (27)
- Detection of histoplasma capsulatum DNA in lesions of chronic ocular histoplasmosis syndrome. (2003) (27)
- Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway. (2011) (27)
- The Role of Sex in Uveitis and Ocular Inflammation (2015) (27)
- Cholera Toxin Prevents Th1-Mediated Autoimmune Disease by Inducing Immune Deviation (2004) (27)
- Naloxone ameliorates retinal lesions in Ccl2/Cx3cr1 double-deficient mice via modulation of microglia. (2011) (26)
- Eyelid myxoma in Carney complex without PRKAR1A allelic loss (2004) (26)
- An estrogen receptor repressor induces cataract formation in transgenic mice (2002) (26)
- Controversial view of a genetically altered mouse model of focal retinal degeneration (2012) (26)
- PNEUMOCYSTIS CARINII AND MYCOBACTERIUM AVIUM‐INTRACELLULARE INFECTION OF THE CHOROID (1992) (26)
- Inflammatory cytokine and chemokine expression in sympathetic ophthalmia: a pilot study. (2011) (26)
- IL-10 -1082 SNP and IL-10 in primary CNS and vitreoretinal lymphomas (2012) (26)
- Effect of Sex Hormones on Experimental Autoimmune Uveoretinitis (EAU) (2003) (26)
- Constitutive and LPS-induced expression of MCP-1 and IL-8 by human uveal melanocytes in vitro and relevant signal pathways. (2014) (26)
- Ocular toxicity of fludarabine: a purine analog (2008) (26)
- Ophthalmic Pathology of Nance-Horan Syndrome: Case Report and Review of the Literature (2009) (26)
- Influence of TIMP3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration (2013) (26)
- Loss of Notch1 Disrupts the Barrier Repair in the Corneal Epithelium (2013) (26)
- Internal en bloc resection and genetic analysis of retinal capillary hemangioblastoma. (2007) (25)
- Endotoxin-induced uveitis in cyclooxygenase-2-deficient mice. (2004) (25)
- Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration (2012) (25)
- Conjunctival involvement with T-cell prolymphocytic leukemia: report of a case and review of the literature. (2004) (25)
- Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. (2006) (25)
- Abrogation of Anti-Retinal Autoimmunity in IL-10 Transgenic Mice Due to Reduced T Cell Priming and Inhibition of Disease Effector Mechanisms1 (2008) (24)
- Similarities between Posterior Polymorphous and Congenital Hereditary Endothelial Dystrophies: A Study of 14 Buttons of 11 Cases (1982) (24)
- Common Genetic Determinants of Uveitis Shared with Other Autoimmune Disorders1 (2008) (24)
- IL‐12 inhibits endotoxin‐induced inflammation in the eye (1996) (23)
- Kinetics of Corneal Transplant Rejection in the Rat Penetrating Keratoplasty Model (1994) (23)
- AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2−/−/Cx3cr1−/− mice (2012) (22)
- Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. (2004) (22)
- An Atypical Form of Bietti Crystalline Dystrophy (2011) (22)
- Mycobacterium-related ocular inflammatory disease: diagnosis and management. (2006) (22)
- Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing: a novel approach. (2013) (21)
- Logistic Regression Classification of Primary Vitreoretinal Lymphoma versus Uveitis by Interleukin 6 and Interleukin 10 Levels. (2020) (21)
- Methimazole protects from experimental autoimmune uveitis (EAU) by inhibiting antigen presenting cell function and reducing antigen priming (2003) (21)
- Subconjunctival Palomid 529 in the treatment of neovascular age-related macular degeneration (2013) (21)
- The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model. (2013) (21)
- TGF-β Inhibits Activation and Uveitogenicity of Primary but Not of Fully Polarized Retinal Antigen-Specific Memory-Effector T Cells (2003) (21)
- Experimental coronavirus retinopathy (ECOR): Retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection (2007) (20)
- Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa (2018) (20)
- Diagnostic Procedures in Vitreoretinal Lymphoma (2014) (20)
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- Le lymphome oculocérébral primitif: diagnostic clinique et cytopathologique (1999) (0)
- melanoma Tumor-specific Th17-polarized cells eradicate large established (2011) (0)
- Adaptive Th 1 and Th 17 Responses Production and Dampening of γ Innate IFN-Autoimmunity by A Mechanism Involving Ameliorates Experimental Ocular Activation of Invariant NKT Cells (2008) (0)
- Histopathology of Age-Related Macular Degeneration and Implications for Pathogenesis and Therapy. (2021) (0)
- regression of large tumors across major histocompatibility barriers Adoptive transfer of allogeneic tumor-specific T cells mediates effective (2011) (0)
- Anti-LFA-1 antibodies enhance metastasis of ocular lymphoma to the brain and contralateral eye (2012) (0)
- Su.127. Eradication of Tumor Colonization and Invasion By a B-Cell Specific Immunotoxin in a Murine Model for Human Primary Intraocular Lymphoma (Piol) (2006) (0)
- Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress (2012) (0)
- Distinct Profiles of Vitreous micro RNA in Primary Vitreoretinal Lymphoma and Uveitis (2013) (0)
- Deficiency of complement anaphylatoxin receptors leads to ameliorated experimental autoimmune uveitis (2015) (0)
- Characterization of ocular lesions in gp91phox-/- and p47phox-/- mice with ocular pathological features of human chronic granulomatous disease (2014) (0)
- Alternative routes of immunization for the uveoretinitis ( EAU ) in rodents : a comparison (2007) (0)
- Autoimmune and autoinflammatory mechanisms in uveitis (2014) (0)
- Ocular and Adnexal T-Cell Lymphoma (2014) (0)
- 93 Essential Role for IL-23 but not for the Th17 Effector Response in Pathogenesis of Experimental Ocular Autoimmunity (2007) (0)
- Suppressor of Cytokine Signaling 1 (SOCS1) Mitigates Anterior Uveitis and Confers Protection Against Ocular HSV-1 Infection (2014) (0)
- Progressive focal retinal degeneration in Ccl2/Cx3cr1 double deficient mice with pathological features of human age-related macular degeneration (2010) (0)
- Masquerade syndromes: Neoplasms (2014) (0)
- Ultrastructural Characterization and Autoantibodies of Melanoma Associated Autoimmune Retinopathy (2012) (0)
- Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of EAU and identify autoaggressive T cells (93.1) (2010) (0)
- Immunological protein expression in the eyes of Ccl2/Cx3cr1 deficient mice, a model of age‐related macular degeneration (2007) (0)
- In-depth analyses unveil the association and possible functional involvement of novel RAD51B polymorphisms in age-related macular degeneration (2014) (0)
- Up‐regulation of apoptosis in Ccl2−/−/Cx3cr1−/− retinal pigment epithelial cells under inflammatory and oxidative stress (2011) (0)
- Special Issue in Honor of Robert B. Nussenblatt, MD, MPH. (2017) (0)
- The role of chemokine CCL-2 and CX3CR1 in inflammatory-related retinal degeneration (2016) (0)
- Clinical andimmunopathological studies ofpars planitis inafamily (1988) (0)
- In Vivo Retinal Degeneration Assessment By 3D Optical Coherence Tomography In The Ccl2/cx3cr1-deficient Mouse (2011) (0)
- Age-related macular degeneration. Commentary (2008) (0)
- Macrophage Polarization in Ccl2/Cx3cr1 Double Deficient Mice (2011) (0)
- Acknowledgement to Reviewers 2005 (2005) (0)
- Environmental Stimuli Enhance Spontaneous Uveitis Elicited By Retina-specific T Cells (2011) (0)
- Macrophages in AMD (2016) (0)
- Sa.59. Interferon-Gamma Influences Manifestations of Autoimmune Disease by Regulating Chemokines (2006) (0)
- Upregulation of Vascular Endothelial Growth Factor (VEGF) and its receptors in non-ischemic retinal disease (1996) (0)
- Monitoring Autoimmune Reactivity within the Retina (2016) (0)
- Pathology of uveitis: Plasma cell infilration of the eye (1987) (0)
- Toll-like receptor 2 and 6 agonist fibroblast-stimulating lipopeptide increases expression and secretion of CXCL1 and CXCL2 by uveal melanocytes. (2022) (0)
- Immunological diseases of the eye (PP-099) (2010) (0)
- Primary intraocular lymphoma (PIOL) is a variant of primary central nervous system lymphoma in which lymphoma cells are initially present only in the eyes without evidence of disease in the brain or cerebrospinal fluid. Patients with PIOL (2001) (0)
- Bone Marrow through STAT 3-Dependent That Mediate Chronic Uveitis Reside in the T Lymphocytes + Autoreactive Memory CD 4 (2011) (0)
- Antibiotic Treatment Exacerbates Focal Retinal Degeneration in a Mouse Model of AMD (2015) (0)
- Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies (2023) (0)
- The role of WNT singling activation and its blockage in the focal retinal lesion of Ccl2-/-/Cx3cr1-/- mice with and without rd8 background (2014) (0)
- Identification of an intraocular microbiota (2021) (0)
- Aberrant endoplasmic reticulum proteins in Ccl2/Cx3cr1 deficient mice with retinal lesions mimicking human age‐related macular degeneration (2007) (0)
- Experimental Models of PIOL (2007) (0)
- Age-related Macular Degeneration (AMD)-like Retinal Lesions and Vision Impairment in Ccl2/Cx3cr1 Double Deficient Mice are Mediated by Fas/FasL Interactions (2011) (0)
- Manufacture of a medicament for the treatment of ocular inflammation by blocking zelladhäsionsmolekulen (1992) (0)
- Effect of HDACi Givinostat in Treating Experimental Ocular Autoimmunity (2015) (0)
- Vitreoretinal Lymphoma (2019) (0)
- Abnormalities in the retinas of mice with a single amino acid mutation in nonmuscle myosin II–B (2004) (0)
- Autoaggressive T Cells Mouse Model of Uveitis and Identify Antigens Are Pathogenic in the Humanized Uveitis-Associated Epitopes of Retinal (2011) (0)
- HLA polymorphisms and autoimmune markers in non-paraneoplastic autoimmune retinopathy (AIR) (2013) (0)
- ICE Syndrome (2005) (0)
- Responses to "Letter to the Editor Regarding 'The Ten Chairmen of the Ophthalmology Department at Peking Union Medical College (PUMC)'" to APJO. (2013) (0)
- The AMD-like Disease in Ccl2-/- and Cx3cr1-/- Mice is Dependent on the Crb1rd8 Retinal Degeneration Mutation Not the Loss of the Chemokine/Chemokine Receptors (2012) (0)
- The Cysteine Prodrug L-2-Oxothiazolidine-4-Carboxylic Acid (OTC) Elicits Potent Antioxidant and Anti-inflammatory Effects in RPE: Relevance to Treatment of Age-Related Macular Degeneration (2012) (0)
- Protective role ofnitric oxide inocular toxoplasmosis (1996) (0)
- Blindness From Septic Thrombophlebitis of the Orbit and Cavernous SinusCaused by Fusobacterium nucleatum (2004) (0)
- Uveal Lymphoma (2019) (0)
- Molecular Identification of Bacterial DNA in the Chorioretinal Scars of Chronic Granulomatous Disease (2013) (0)
- Extranuclear DNA: a Normal Phenomenon or an Indication of Pathology? (2013) (0)
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