Chris Abell
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Chris Abellchemistry Degrees
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Organic Chemistry
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Chemistry
Chris Abell's Degrees
- Bachelors Chemistry University of Oxford
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(Suggest an Edit or Addition)Chris Abell's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. (2010) (926)
- Kinematical studies of the flows around free or surface-mounted obstacles; applying topology to flow visualization (1978) (678)
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge (2016) (670)
- High-throughput crystallography for lead discovery in drug design (2002) (477)
- Fragment-based approaches in drug discovery and chemical biology. (2012) (375)
- One-Step Fabrication of Supramolecular Microcapsules from Microfluidic Droplets (2012) (351)
- Quantitative detection of protein expression in single cells using droplet microfluidics. (2007) (343)
- Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. (2009) (308)
- Tough Supramolecular Polymer Networks with Extreme Stretchability and Fast Room‐Temperature Self‐Healing (2017) (282)
- Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets. (2009) (243)
- Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsions. (2010) (206)
- Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance. (2008) (199)
- Surface-induced droplet fusion in microfluidic devices. (2007) (193)
- Development of quantitative cell-based enzyme assays in microdroplets. (2008) (188)
- A reversible pH-driven DNA nanoswitch array. (2006) (185)
- Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays. (2009) (181)
- An Integrated Device for Monitoring Time‐Dependent in vitro Expression From Single Genes in Picolitre Droplets (2008) (176)
- Direct and sensitive detection of a human virus by rupture event scanning (2001) (169)
- Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. (2013) (166)
- Biomimetic Supramolecular Polymer Networks Exhibiting both Toughness and Self‐Recovery (2017) (161)
- Chiral discrimination by chemical force microscopy (1998) (158)
- Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online. (2009) (157)
- Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments. (2009) (155)
- From microdroplets to microfluidics: selective emulsion separation in microfluidic devices. (2008) (153)
- Cucurbit[n]uril-Based Microcapsules Self-Assembled within Microfluidic Droplets: A Versatile Approach for Supramolecular Architectures and Materials (2017) (151)
- Writing with DNA and protein using a nanopipet for controlled delivery. (2002) (140)
- A double droplet trap system for studying mass transport across a droplet-droplet interface. (2010) (138)
- Evolution of enzyme catalysts caged in biomimetic gel-shell beads. (2014) (133)
- Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. (2006) (131)
- Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA. (2005) (131)
- A compact functional quantum Dot-DNA conjugate: preparation, hybridization, and specific label-free DNA detection. (2008) (130)
- Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. (2009) (128)
- Biosynthesis of pantothenate. (2004) (126)
- Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry (2016) (124)
- Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. (2006) (119)
- A three-stage biophysical screening cascade for fragment-based drug discovery (2013) (117)
- Using a Fragment-Based Approach To Target Protein–Protein Interactions (2013) (117)
- Differentially Addressable Cavities within Metal-Organic Cage-Cross-Linked Polymeric Hydrogels. (2015) (116)
- Experiences with the shikimate-pathway enzymes as targets for rational drug design. (2003) (115)
- Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. (2012) (112)
- Fragment-based approaches to enzyme inhibition. (2007) (102)
- Fabrication of microgel particles with complex shape via selective polymerization of aqueous two-phase systems. (2012) (99)
- Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery (2013) (99)
- Biosynthesis of pentalenene and pentalenolactone (1990) (94)
- Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. (2009) (93)
- Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing (1998) (91)
- Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. (2003) (91)
- Quantitative tracking of the growth of individual algal cells in microdroplet compartments. (2011) (91)
- Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (2018) (90)
- Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain (2013) (88)
- An addressable antibody nanoarray produced on a nanostructured surface. (2004) (85)
- An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets. (2009) (84)
- Bioinspired supramolecular fibers drawn from a multiphase self-assembled hydrogel (2017) (84)
- Escherichia coli L-aspartate-alpha-decarboxylase: preprotein processing and observation of reaction intermediates by electrospray mass spectrometry. (1997) (82)
- Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. (2012) (75)
- The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. (2002) (74)
- Drugging challenging targets using fragment-based approaches. (2010) (73)
- Interfacial assembly of dendritic microcapsules with host–guest chemistry (2014) (71)
- Isolation and characterisation of a cDNA clone for a chlorophyll synthesis enzyme from Euglena gracilis. The chloroplast enzyme hydroxymethylbilane synthase (porphobilinogen deaminase) is synthesised with a very long transit peptide in Euglena. (1989) (71)
- Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. (2014) (69)
- Salicylate Biosynthesis: Overexpression, Purification, and Characterization of Irp9, a Bifunctional Salicylate Synthase from Yersinia enterocolitica (2005) (67)
- Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. (2010) (67)
- Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1** (2012) (66)
- The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. (2001) (62)
- Simultaneous measurement of reactions in microdroplets filled by concentration gradients. (2009) (62)
- High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform (2015) (62)
- Observation of an imine intermediate on dehydroquinase by electrospray mass spectrometry (1991) (62)
- Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. (2004) (62)
- Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum. (2014) (61)
- Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases. (1996) (61)
- Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identification (2012) (61)
- Pantothenate biosynthesis in higher plants. (2005) (61)
- Afm study on protein immobilization on charged surfaces at the nanoscale: Toward the fabrication of three-dimensional protein nanostructures (2003) (60)
- SOLID PHASE ALDOL AND CONJUGATE ADDITION REACTIONS USING EVANS' OXAZOLIDINONE CHIRAL AUXILIARY (1998) (59)
- Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding. (1991) (59)
- Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry. (2013) (58)
- Structural constraints on protein self‐processing in L‐aspartate‐α‐decarboxylase (2003) (58)
- Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism. (2001) (57)
- Binding of vancomycin group antibiotics to D-alanine and D-lactate presenting self-assembled monolayers. (2000) (56)
- Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate (2008) (55)
- Different mechanistic and stereochemical courses for the reactions catalysed by type I and type II dehydroquinases (1993) (55)
- Direct and quantitative detection of bacteriophage by "hearing" surface detachment using a quartz crystal microbalance. (2001) (53)
- From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1** (2011) (53)
- Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support (1997) (51)
- Calibration of AFM cantilever spring constants. (2003) (51)
- Monitoring a reaction at submillisecond resolution in picoliter volumes. (2011) (51)
- Supramolecular hydrogel microcapsules via cucurbit[8]uril host–guest interactions with triggered and UV-controlled molecular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01440a Click here for additional data file. (2015) (50)
- The use of a dithiane protected benzoin photolabile safety catch linker for solid-phase synthesis (1997) (49)
- A fragment-based approach to identifying ligands for riboswitches. (2010) (47)
- Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate: Proof that the cyclization is catalyzed by a single enzyme (1984) (47)
- Solution-phase synthesis of 2,6,9-trisubstituted purines (1998) (46)
- Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites. (2003) (46)
- Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors (2016) (45)
- Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9. (1994) (45)
- The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice). (1999) (45)
- Unexpected stability of aqueous dispersions of raspberry-like colloids (2018) (45)
- The design and synthesis of inhibitors of pantothenate synthetase. (2006) (45)
- A nondestructive technique for determining the spring constant of atomic force microscope cantilevers (2001) (44)
- A Fragment‐Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (2009) (44)
- Supramolecular Nested Microbeads as Building Blocks for Macroscopic Self‐Healing Scaffolds (2018) (43)
- Fragment screening against the thiamine pyrophosphate riboswitchthiM (2011) (43)
- Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate. (2006) (43)
- Escherichia coli dihydrodipicolinate synthase: characterization of the imine intermediate and the product of bromopyruvate treatment by electrospray mass spectrometry. (1995) (42)
- Targeting a c-MYC G-quadruplex DNA with a fragment library. (2014) (42)
- 1.22 – Enzymology and Molecular Biology of the Shikimate Pathway (1999) (42)
- Escherichia coli Chorismate Synthase Catalyzes the Conversion of (6S)-6-Fluoro-5-enolpyruvylshikimate-3-phosphate to 6-Fluorochorismate (1995) (41)
- Label-free detection of DNA hybridization at the nanoscale: a highly sensitive and selective approach using atomic-force microscopy. (2003) (41)
- Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly. (2006) (40)
- Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis (2018) (40)
- An Investigation into Solid-Phase Radical Chemistry - Synthesis of Furan Rings (2004) (40)
- Selective Inhibition of Type II Dehydroquinases. (1999) (40)
- Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6s)-6-fluoroshikimate. (2004) (38)
- Fabrication of Three‐Dimensional Surface Structures with Highly Fluorescent Quantum Dots by Surface‐Templated Layer‐by‐Layer Assembly (2005) (38)
- Reaction of (6R)-6-fluoroEPSP with recombinant Escherichia coli chorismate synthase generates a stable flavin mononucleotide semiquinone radical (1992) (36)
- Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain (2016) (36)
- Fluorosurfactants for microdroplets: interfacial tension analysis. (2010) (36)
- Enzymatic formation of lactams in organic solvents (1992) (36)
- Label-Free Analysis and Sorting of Microalgae and Cyanobacteria in Microdroplets by Intrinsic Chlorophyll Fluorescence for the Identification of Fast Growing Strains. (2016) (36)
- Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme (1993) (35)
- Supramolecular colloidosomes: fabrication, characterisation and triggered release of cargo. (2014) (35)
- Mechanistic and inhibition studies of chorismate-utilizing enzymes. (2005) (35)
- Controlling the contents of microdroplets by exploiting the permeability of PDMS. (2011) (34)
- Microdroplet fabrication of silver–agarose nanocomposite beads for SERS optical accumulation (2011) (34)
- Single molecule fluorescence under conditions of fast flow. (2012) (34)
- Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. (2010) (34)
- Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases (2014) (34)
- Electrostatically Directed Self-Assembly of Ultrathin Supramolecular Polymer Microcapsules (2015) (34)
- Posttranslational modification of Klebsiella pneumoniae flavodoxin by covalent attachment of coenzyme A, shown by 31P NMR and electrospray mass spectrometry, prevents electron transfer from the nifJ protein to nitrogenase. A possible new regulatory mechanism for biological nitrogen fixation. (1992) (34)
- Studies with Substrate and Cofactor Analogues Provide Evidence for a Radical Mechanism in the Chorismate Synthase Reaction* (2000) (32)
- Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors (2007) (32)
- Crystal Structure of Escherichia coli Ketopantoate Reductase in a Ternary Complex with NADP+ and Pantoate Bound (2007) (32)
- The sequence of hemC, hemD and two additional E. coli genes. (1988) (32)
- Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. (2011) (32)
- Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site (2016) (32)
- Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids (1997) (31)
- A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection. (2011) (31)
- The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. (2005) (31)
- Purification, characterization, crystallisation and X-ray analysis of selenomethionine-labelled hydroxymethylbilane synthase from Escherichia coli. (1993) (31)
- Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS. (2016) (30)
- The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations (2014) (30)
- Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121 (2013) (29)
- Inhibition studies on salicylate synthase. (2005) (29)
- Uroporphyrinogen III synthase: Studies on its mechanism of action, molecular biology and biochemistry (1991) (29)
- Evidence for opposite stereochemical courses for the reaction catalysed by type I and type II dehydrocquinases (1993) (29)
- High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay** (2012) (28)
- Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets. (2012) (28)
- Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams (2010) (28)
- Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification (2010) (28)
- Method to determine the spring constant of atomic force microscope cantilevers (2004) (28)
- Management of the diffusion of 4‐methylumbelliferone across phases in microdroplet‐based systems for in vitro protein evolution (2010) (27)
- Observation of an isotope effect in the chorismate synthase reaction (1990) (27)
- A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR. (2014) (27)
- Microfluidic Droplet-Facilitated Hierarchical Assembly for Dual Cargo Loading and Synergistic Delivery (2015) (27)
- Formation of Cucurbit[8]uril-Based Supramolecular Hydrogel Beads Using Droplet-Based Microfluidics. (2015) (27)
- Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues. (2012) (27)
- MicroRNA-specific argonaute 2 protein inhibitors. (2013) (26)
- Role of Surface Perfection in Chemical Force Microscopy. (1998) (26)
- Inhibition of chorismate synthase by (6R)- and (6S)-6-fluoro-5-enolpyruvylshikimate 3-phosphate (1991) (26)
- Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding. (2017) (26)
- The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions. (2015) (26)
- Pantothenate biosynthesis in higher plants: advances and challenges (2006) (25)
- Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping (2019) (25)
- Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. (1991) (25)
- Patterned Arrays of Supramolecular Microcapsules (2018) (25)
- Intra-Species Bacterial Quorum Sensing Studied at Single Cell Level in a Double Droplet Trapping System (2013) (24)
- Droplet-based microfluidic analysis and screening of single plant cells (2017) (23)
- Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis (2015) (23)
- Synthesis of (2R)-2-bromodehydroquinic acid and(2R)-2-fluorodehydroquinicacid (1997) (23)
- Real Time Dual-Channel Multiplex SERS Ultradetection. (2014) (23)
- Combinatorial synthetic design. (1999) (23)
- Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy. (2006) (22)
- Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. (2009) (22)
- ENZYMATIC SYNTHESIS OF (6R)- AND (6S)-FLUOROSHIKIMIC ACIDS (1995) (22)
- Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches (2019) (22)
- Enzyme synthesis and activity assay in microfluidic droplets on a chip (2011) (22)
- Nanomolar Inhibition of Type II Dehydroquinase Based on the Enolate Reaction Mechanism (2007) (22)
- 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site. (2019) (21)
- Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach (2017) (21)
- Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases (2007) (21)
- Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli. (1986) (21)
- Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays (2016) (21)
- A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines (1999) (21)
- Lipophilic modification of oligonucleotides (1997) (21)
- Chemical force microscopy with active enzymes. (2001) (20)
- Specificity of E. Coli shikimate dehydrogenase towards analogues of 3-dehydroshikimic acid (1988) (20)
- Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking. (2014) (20)
- A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine Peptide Library (1997) (20)
- Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase. (2003) (19)
- Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis (2015) (19)
- (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. (2004) (19)
- The biochemical properties of the two Arabidopsis thaliana isochorismate synthases (2017) (18)
- Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors (2019) (18)
- Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction (2001) (18)
- Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase. (2003) (18)
- Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches. (2011) (18)
- Fragment-based approaches to TB drugs (2016) (17)
- Escherichia coli chorismate synthase: a deuterium kinetic-isotope effect under single-turnover and steady-state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved. (1995) (17)
- Structural insights into the evolution of the pantothenate-biosynthesis pathway. (2003) (17)
- Structural insights into the EthR-DNA interaction using native mass spectrometry. (2017) (17)
- Dual-responsive supramolecular colloidal microcapsules from cucurbit[8]uril molecular recognition in microfluidic droplets (2016) (16)
- Inhibition of Ral GTPases Using a Stapled Peptide Approach* (2016) (16)
- A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death (2020) (16)
- Observation of a secondary tritium isotope effect in the chorismate synthase reaction. (1995) (16)
- Rv2607 from Mycobacterium tuberculosis Is a Pyridoxine 5′-Phosphate Oxidase with Unusual Substrate Specificity (2011) (16)
- A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters (1999) (16)
- Droplet-based microfluidic screening and sorting of microalgal populations for strain engineering applications☆ (2021) (15)
- Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions. (2013) (15)
- Applications of Microdroplet Technology for Algal Biotechnology (2016) (15)
- Tri-partite complex for axonal transport drug delivery achieves pharmacological effect (2010) (15)
- Mass Spectrometry Reveals Protein Kinase CK2 High-Order Oligomerization via the Circular and Linear Assembly. (2016) (15)
- The use of 2H n.m.r. spectroscopy and β-isotopic shifts in the 13C n.m.r. spectrum to measure deuterium retention in the biosynthesis of the polyketide 6-methylsalicylic acid (1981) (15)
- Synthesis of 2-Bromo- and 2-Fluoro-3-dehydroshikimic Acids and 2-Bromo- and 2-Fluoroshikimic Acids Using Synthetic and Enzymatic Approaches (1998) (15)
- Mass spectrometry for fragment screening. (2017) (15)
- The use of trichloroacetimidate-activated resin for ester formation (1998) (15)
- Design and synthesis of aromatic inhibitors of anthranilate synthase. (2005) (15)
- Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate. Anti stereochemistry in a biological SE' reaction (1988) (15)
- Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. (2010) (14)
- Influence of the foundation layer on the layer-by-layer assembly of poly-L-lysine and poly(styrenesulfonate) and its usage in the fabrication of 3D microscale features. (2004) (14)
- Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1* (2016) (14)
- Investigating the specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single-molecule force spectroscopy. (2007) (14)
- Pantothenic Acid Biosynthesis in the Parasite Toxoplasma gondii: a Target for Chemotherapy (2014) (14)
- How Much Chemistry is There in Chemical Force Microscopy? (1999) (14)
- 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action. (2019) (14)
- Evidence for consecutive 1,2-alkyl shifts in sterpurene biosynthesis: isolation and characterisation of 7,12-dihydroxysterpurene (1987) (14)
- Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics. (2020) (14)
- Microcapsule Buckling Triggered by Compression-Induced Interfacial Phase Change. (2016) (14)
- Viscoelastic Hydrogel Microfibers Exploiting Cucurbit[8]uril Host–Guest Chemistry and Microfluidics (2020) (14)
- Novel chemical tagging method for combinatorial synthesis utilizing suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry. (2001) (14)
- Disrupting the Constitutive, Homodimeric Protein–Protein Interface in CK2β Using a Biophysical Fragment-Based Approach (2016) (14)
- Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine. (1990) (14)
- Vinyl fluoride as an isoelectronic replacement for an enolate anion: inhibition of type II dehydroquinases. (2002) (14)
- Detection of Covalent Intermediates Formed in the Reaction of 4‐Amino‐4‐deoxychorismate Synthase (2005) (14)
- Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors (2016) (14)
- Towards engineering increased pantothenate (vitamin B5) levels in plants (2008) (14)
- Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification (2019) (14)
- Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites. (2003) (13)
- The absolute stereochemistry of the enzymic cyclisation to form the sterpurene sesquiterpenes (1988) (13)
- Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase. (2000) (13)
- Affinity labelling of E. coli dehydroquinase (1988) (13)
- Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis. (2016) (12)
- Insight into Protein Conformation and Subcharging by DMSO from Native Ion Mobility Mass Spectrometry (2016) (12)
- Biosynthesis of the fungal metabolites alternariol, mellein, rubrofusarin, and 6-methylsalicylic acid from CD3CO2H (1982) (12)
- Ligand‐Observed NMR in Fragment‐Based Approaches (2012) (12)
- Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation. (2014) (12)
- Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis (2016) (12)
- Bioinspired hydrogel microfibres colour-encoded with colloidal crystals (2019) (12)
- Evidence for the pathway to pantothenate in plants (1994) (12)
- Differential Scanning Fluorimetry as Part of a Biophysical Screening Cascade (2016) (12)
- Coenzyme biosynthesis: enzyme mechanism, structure and inhibition. (2007) (11)
- A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis (2021) (11)
- Rational design of new bifunctional inhibitors of type II dehydroquinase. (2005) (11)
- Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design (2015) (11)
- Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids. (2000) (11)
- Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). (1989) (11)
- Discovery of Schaeffer’s Acid Analogues as Lead Structures of Mycobacterium tuberculosis Type II Dehydroquinase Using a Rational Drug Design Approach (2013) (11)
- Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy. (2010) (11)
- Structure‐activity relationship of the peptide binding‐motif mediating the BRCA2:RAD51 protein–protein interaction (2016) (11)
- Systematic manipulation of surface chemical reaction on the nanoscale: a novel approach for constructing three-dimensional nanostructures. (2003) (10)
- Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis. (2005) (10)
- Surface-immobilised micelles via cucurbit[8]uril-rotaxanes for solvent-induced burst release. (2015) (10)
- pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study (2007) (10)
- Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxy-dehydroquinic acid (1996) (9)
- Derailing Dehydroquinate Synthase by Introducing a Stabilizing Stereoelectronic Effect in a Reaction Intermediate. (1997) (9)
- Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate. (2001) (9)
- Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry. (2017) (9)
- Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode. (2019) (9)
- Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies (1997) (9)
- Design and synthesis of aromatic inhibitors of anthranilate synthase. (2005) (9)
- Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach. (2016) (9)
- Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia). (2003) (9)
- Preparation of Symmetrical and Unsymmetrical DNA–Protein Conjugates with DNA as a Molecular Scaffold (2001) (8)
- Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action (2017) (8)
- A Convenient Method for the Synthesis of Dehydroquinic Acid (2003) (8)
- Focused surface acoustic waves induced microdroplets generation and its application for microgels (2019) (8)
- Chiral discrimination of basic and hydrophobic molecules by chemical force spectroscopy. (2003) (8)
- Design and Structural Analysis of Aromatic Inhibitors of Type II Dehydroquinase from Mycobacterium tuberculosis (2015) (8)
- Nucleophile Selectivity of Chorismate‐Utilizing Enzymes (2007) (8)
- The Stability of Polyuridylic Acid in Acid Solution (1965) (8)
- Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51 (2016) (8)
- Motile Artificial Chromatophores: Light‐Triggered Nanoparticles for Microdroplet Locomotion and Color Change (2019) (7)
- Biosynthesis of the pigments of life: Structure and mode of action of a novel enzymatic cofactor (1989) (7)
- Biosynthesis of the polyketide mellein from CD3CO2H and 13CD3CO2H in Aspergillus melleus: detection of deuterium by 2H n.m.r. and edited 13C n.m.r. spectra (1983) (7)
- The synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-enolpyruvylshikimate-3-phosphate (1991) (7)
- Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. (2020) (7)
- Supracolloidal Architectures Self-Assembled in Microdroplets. (2015) (7)
- Single-step biocompatible coating for sulfhydryl coupling of receptors using 2-(pyridinyldithio)ethylcarbamoyl dextran. (2008) (7)
- The absolute configuration of the sterpurene sesquiterpenes (1988) (7)
- An amino acid sequence motif observed amongst enzymes of the shikimate pathway. (1991) (7)
- Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126 (2014) (7)
- Biosynthesis of 6-methylsalicylic acid; the combined use of mono- and tri-duteriated acetate precursors to investigate the degree of stereocontrol in the aromatisation sequence (1984) (7)
- Biomimetic syntheses of the polyketide fungal metabolites alternariol and rubrofusarin: models for cyclisation reactions catalysed by polyketide synthase enzymes (1986) (6)
- A novel phase-switching protecting group for multi-step parallel solution phase synthesis. (2004) (6)
- Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes. (2006) (6)
- Construction of core-shell microcapsules via focused surface acoustic wave microfluidics. (2020) (6)
- Small-Molecule Inhibitors That Target Protein – Protein Interactions in the RAD 51 Family of Recombinases (2015) (6)
- Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase (2014) (6)
- A novel anthracenyl tagged protecting group for "phase-switching" applications in parallel synthesis. (2003) (6)
- A simple method for the preparation of 3-hydroxyiminodehydroquinate, a potent inhibitor of type II dehydroquinase (2002) (6)
- Structure of (–)-quinic acid (1988) (6)
- Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. (2012) (6)
- Synthesis of 4-deoxyquinic, 4-deoxyshikimic and 4-deoxy-3-dehydroshikimic acids (1999) (6)
- Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. (2001) (6)
- Comparative Analysis of the Escherichia coli Ketopantoate Hydroxymethyltransferase Crystal Structure Confirms that It Is a Member of the (βα)8 Phosphoenolpyruvate/Pyruvate Superfamily (2003) (6)
- The resolution of diterpene cyclase activities from Ricinus communis (1994) (6)
- Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1. (2017) (6)
- Microdroplets confined assembly of opal composites in dynamic borate ester-based networks (2020) (5)
- Fragment-Based Drug Discovery (2015) (5)
- Cucurbit[7]uril-based high-performance catalytic microreactors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/C8NR02900H (2018) (5)
- Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice (2018) (4)
- The Use of NMR Spectroscopy to Follow Deuterium in Studies of Fungal Metabolism (1986) (4)
- Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site (2019) (4)
- Fragment-based drug discovery in academia: Experiences from a tuberculosis programme (2009) (4)
- AN ELECTROCHEMICAL STUDY TO MODEL THE CHORISMATE SYNTHASE REACTION (1996) (4)
- Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site (2021) (4)
- Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics (2020) (4)
- Research data supporting "Supramolecular hydrogel microcapsules via cucurbit[8]uril host–guest interactions with triggered and UV-controlled molecular permeability" (2015) (3)
- Chapter 16:Discovery and Extrapolation of Fragment Structures towards Drug Design (2007) (3)
- Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach. (2022) (3)
- Enzymes that exploit imines--one way or the other. (1998) (3)
- The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis (2000) (3)
- Structural Insights into Escherichia coli Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometry. (2019) (3)
- Studies on the biosynthesis of hydroxymellein using 17O n.m.r. and 2H n.m.r. spectroscopy to determine the origin of the C-4 hydroxy group (1987) (3)
- ATP half‐sites in RadA and RAD51 recombinases bind nucleotides (2016) (3)
- Use of Quinic Acid as Template in Solid-Phase Combinatorial Synthesis (1999) (2)
- A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) (2022) (2)
- CHAPTER 1:Different Flavours of Fragments (2015) (2)
- Successful use of axonal transport for drug delivery by synthetic molecular vehicles (2008) (2)
- Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. (2022) (2)
- Sensitive and direct detection using rupture event scanning (REVS/spl trade/) (2002) (2)
- Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference (2020) (2)
- Comparative study of the protection of modified and unmodified dsDNA by cationic and non-cationic lipids and liposomes to digestion by DNase I (1998) (2)
- Approaches to Antibody-Catalyzed Cationic Cyclizations: Chemical Studies of Leaving Groups and Cyclization Modes (1996) (2)
- Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility (2021) (2)
- Enzymic synthesis of 3-[3- 13C]dehydroquinic acid. (2003) (2)
- Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design (2022) (2)
- Solution-Phase Synthesis of 2,6,9-Trisubstituted Purines. (1998) (1)
- The use of FTICR-MS to detect chemical tags from a combinatorial library. (2002) (1)
- Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity (2021) (1)
- Synthesis of (2R)-2-Bromodehydroquinic Acid and (2R)-2- Fluorodehydroquinic Acid. (1997) (1)
- Design and synthesis of transition-state analogues for a cationic cyclisation (1994) (1)
- Novel selenium containing non-detergent sulphobetaines (2003) (1)
- Research data supporting “Dual-responsive supramolecular colloidal microcapsules from cucurbit[8]uril molecular recognition in microfluidic droplets” (2016) (1)
- Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH). (2019) (1)
- Crystal structure of ketopantoate reductase in complex with NADP (2005) (1)
- Crystal structure of pantothenate synthetase in complex with 2-(2-(benzofuran-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid (2009) (1)
- Combinatorial Synthetic Design (1999) (1)
- Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics (2022) (1)
- Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections (2022) (1)
- Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis (2020) (1)
- Novel Selenium‐Containing Non‐Detergent Sulfobetaines. (2004) (1)
- Structure of sodium (–)‐shikimate dihydrate (1988) (1)
- Type II Dehydroquinase from Mycobacterium tuberculosis complexed with 2,3-anhydro-quinic acid (2003) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 22 at 1.84A resolution (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 22 (Ethyl 1H-pyrazole-4-carboxylate) (2020) (0)
- Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in apo form (2021) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 15 (6-quinoxalinamine) (2020) (0)
- Structure of humanised RadA-mutant humRadA22F in complex with 1-Indane-6-carboxylic acid (2016) (0)
- Crystal Structure of Ketopantoate Hydroxymethyltransferase complexed the Product Ketopantoate (2003) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE (2016) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 1 at 1.63A resolution (2016) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with (E)-3-(furan-3-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one at 1.78A resolution (2017) (0)
- HumRadA33F in complex with peptidic inhibitor 6 (2021) (0)
- Fragment-based approaches for anti-tuberculosis drug discovery (2013) (0)
- The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide (2012) (0)
- Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with Histidine 11 Mutated to Alanine (2003) (0)
- Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with ATP (2021) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTU TETRAPEPTIDE (2016) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.40 Ang resolution in complex with fragment compound 1-Benzofuran-2-carboxylic acid (2009) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-[3-(trifluoromethyl)phenyl]prop-2-enoic acid (2020) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
- Pantothenate synthetase in complex with racemate (2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID and (2R)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID (2013) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acid (2009) (0)
- Unliganded form of Polo-like kinase I Polo-box domain (2011) (0)
- ketopantoate reductase: a structural and calorimetric study (2007) (0)
- Humanised monomeric RadA in complex with FHTA tetrapeptide (2013) (0)
- CRYSTAL APO-STRUCTURE OF PANTOTHENATE SYNTHETASE FROM E. COLI (2001) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with S-Adenosyl methionine (2020) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-((tetrahydrofuran-3-yl)methyl)pyrrolidine-1-carboxamide at 1.93A resolution (2017) (0)
- Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor (0)
- T. maritima ThyX in complex with TyC5-03 (2016) (0)
- 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with 3-hydroxyimino-quinic acid (2003) (0)
- Ketopantoate Reductase from Escherichia coli (2002) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 16 (2-Amino-3-nitropyridine) (2020) (0)
- A Convenient Method for the Synthesis of Dehydroquinic Acid. (2003) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 12 (2-Aminobenzothiazole) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 10 (2-Amino-5-bromobenzothiazole) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 8 (3-[(2-thienylthio)methyl]benzoic acid) (2020) (0)
- Development of potent inhibitors by fragment‐linking strategies (2022) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 2 at 1.68A resolution (2016) (0)
- Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment 2 (0)
- Surface flexibility of Plk1 – implications in substrate binding and drug design (2011) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 1 (1H-Indole-5-carboxamide) (2020) (0)
- Research data supporting “Label-free analysis and sorting of microalgae and cyanobacteria in microdroplets by intrinsic chlorophyll fluorescence for the identification of fast growing strain” (2016) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 28 at 1.99A resolution (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 14 (Methyl 2-aminopyridine-4-carboxylate) (2020) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.80 Ang resolution in complex with 5'-deoxy-5'-thioadenosine (2009) (0)
- Polo-like kinase I Polo-box domain in complex with FMPPPMSpSM phosphopeptide from TCERG1 (2011) (0)
- RadA C-terminal ATPase domain from Pyrococcus furiosus (2012) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 9 (Adenine) (2020) (0)
- Processed Aspartate Decarboxylase Mutant with Ser25 mutated to Cys (2003) (0)
- Mycobacterium tuberculosis protein Rv1155 in complex with co-enzyme F420 (2015) (0)
- Polo-like kinase I Polo-box domain in complex with MQSpSPL phosphopeptide (2011) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution (2016) (0)
- Crystal structure of the E. coli thiM riboswitch in complex with thieno[2,3-b]pyrazin-7-amine (2014) (0)
- n of CK 2 a from an anchor outside the active site † (2016) (0)
- Design and structural analysis of aromatic inhibitors of type II dehydroquinase dehydratase from Mycobacterium tuberculosis - compound 35c [3,4-dihydroxy-5-(3-nitrophenoxy)benzoic acid] (2014) (0)
- Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-Methoxy-N-(5-methylpyridin-2-ylsulfonyl)-1H-indole-2-carboxamide (2009) (0)
- A simple method for the preparation of 3-hydroxyiminodehydroquinate,The IUPAC name for 3-hydroxyiminodehydroquinate is (1S,4R,5R)-1,4,5-trihydroxy-3-(hydroxyimino)cyclohexane-1-carboxylate. a potent inhibitor of type II dehydroquinase (2002) (0)
- Biosynthesis of Pantothenate (2005) (0)
- T57V mutant of aspartate decarboxylase (2012) (0)
- Systematic manipulation of surfaces by sequential nanoscale chemical reactions: a novel approach for constructing three dimensional nanostructures (2003) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 21 (2-Amino-3-nitrophenol) (2020) (0)
- Research data supporting "A fragment-based approach to targeting IMPDH from Mycobacterium tuberculosis" (2018) (0)
- Preparation of molecular arrays (2002) (0)
- A sensitive and economical method to directly detect particles (2002) (0)
- Cell Based Biological Assay Using Microfluidics (2008) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azocan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
- Synthesis of 4-Deoxyquinic, 4-Deoxyshikimic and 4-Deoxy-3-dehydroshikimic Acid. (1999) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 5 (Isoxazole-5-carboxamide) (2020) (0)
- Processed Aspartate Decarboxylase Mutant with Asn72 mutated to Ala (2012) (0)
- Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (2018) (0)
- Enzymatic Formation of Lactams in Organic Solvents. (1992) (0)
- Crystal structure of the E. coli thiM riboswitch in complex with hypoxanthine (2014) (0)
- Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells. (2022) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 6 (2-(1,3-oxazol-5-yl) aniline) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 24 (Indole-6-boronic acid) (2020) (0)
- PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE (1998) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.95 Ang resolution in complex with 5'-deoxy-5'-((R)-3,4-dihydroxybutylthio)-adenosine (2009) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid (2010) (0)
- RSC_IB_C1IB00033K 1..9 (2011) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 5 at 1.57A resolution (2016) (0)
- Addressable Macroscopic 2D networks self-assembled from nanometre size protein/DNA complexes (2006) (0)
- Apo-structure of humanised RadA-mutant humRadA22F (2016) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH FHPA TETRAPEPTIDE (2016) (0)
- Supplementary material from "Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping" (2019) (0)
- Crystal structure of the E. coli thiM riboswitch in complex with (4-(1,2,3-thiadiazol-4-yl)phenyl)methanamine (2014) (0)
- Coenzyme Biosynthesis: Enzyme Mechanism, Structure and Inhibition (2008) (0)
- The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide (2012) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-hydroxynaphthalene-2-carboxylic acid (2020) (0)
- Crystal structure of 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with inhibitor 2 (2011) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 13 (4-Hydroxyquinazoline) (2020) (0)
- Kinetics of protein expression in single cells using microfluidics (2008) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(quinolin-4-yl)acetamide (2019) (0)
- Crystal structure of Yersinia enterocolitica salicylate synthase (Irp9) (2006) (0)
- Research data supporting 'Wu et al., Bioinspired supramolecular fibers drawn from a multi-phase self-assembled hydrogel, PNAS, 2017' (2018) (0)
- Wales Andrew Wheatley Paul Wood Peter Wothers Dominic Wright An introduction to Cambridge Chemistry Academic staff (2012) (0)
- Crystal structure of the E. coli thiM riboswitch in complex with 5-(azidomethyl)-2-methylpyrimidin-4-amine (2014) (0)
- Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors (2017) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor (2019) (0)
- Research Data Supporting "Substrate fragmentation for the design of M. tuberculosis CYP121 inhibitors" (2016) (0)
- Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (2022) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 3 at 1.84A resolution (2016) (0)
- Pink Doesn’t Exist! - A Tale of Trophoblast Differentiation (2017) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 15 at 1.76A resolution (2016) (0)
- Humanised monomeric RadA in complex with 5-methyl indole (2013) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 19 (5-fluoroquinazolin-4-ol) (2020) (0)
- Structure of CYP121 in complex with 4-(4-phenoxy-1H-pyrazol-3-yl)benzene-1,3-diol (2012) (0)
- Research data supporting "Supramolecular nested microbeads as building blocks for macroscopic self-healing scaffolds" (2018) (0)
- S25A mutant of pyruvoyl dependent aspartate decarboxylase (2003) (0)
- Humanised monomeric RadA in complex with 5-hydroxy indole (2013) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 21 at 1.7A resolution (2016) (0)
- Structure of cytochrome P450 CYP121 in complex with 4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylate (2012) (0)
- Structure of cytochrome P450 CYP121 in complex with 4-(1H-1,2,4-triazol-1-yl)phenol (2012) (0)
- Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target. (2023) (0)
- Palladium‐Catalyzed Carbon–Carbon Bond Formation on Solid Support (2002) (0)
- Research data supporting "Structural insights into the EthR-DNA interaction using native mass spectrometry" (2017) (0)
- Glycine 24 to Serine mutation of aspartate decarboxylase (2003) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 7 (2-Amino-6-fluorobenzothiazole) (2020) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 23 (3-Amino-5-(4-methoxyphenyl)pyrazole) (2020) (0)
- Humanised monomeric RadA in complex with napht-1-ol (2013) (0)
- Probing cell to cell variations in gene expression using microfluidics (2009) (0)
- Type II Dehydroquinase inhibitor complex (2006) (0)
- Polo-like kinase I Polo-box domain in complex with FDPPLHSpTA phosphopeptide from PBIP1 (2011) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 4 at 1.87A resolution (2016) (0)
- MEGAHERTZ-GENERATED FEMTOLITER MICROFLUIDIC DROPLETS FOR SINGLE-MOLECULE-COUNTING IMMUNOASSAY (2013) (0)
- Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors (2020) (0)
- Regioselective Conversion of Arenes to N-Aryl-1,2,3-triazoles Using C—H Borylation. (2015) (0)
- Humanised monomeric RadA in complex with 2-amino benzothiazole (2013) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate (2016) (0)
- Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1 (2013) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-(cyclopentylmethyl)pyrrolidine-1-carboxamide at 1.77A resolution (2017) (0)
- Humanised monomeric RadA in complex with 4-methylester indole (2013) (0)
- Inside Cover: A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009) (2009) (0)
- Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) (2021) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 3 (2-(5-Isoxazolyl) phenol) (2020) (0)
- Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with an Alanine insertion at position 26 (2003) (0)
- Syntheses of 2‐Bromo‐ and 2‐Fluoro‐3‐dehydroshikimic Acids and 2‐Bromo‐ and 2‐Fluoroshikimic Acids Using Synthetic and Enzymatic Approaches. (1998) (0)
- Studies on the Synthesis, Characterization and Reactivity of Aromatic Diboronic Acids. (1997) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTG TETRAPEPTIDE (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in Apo form (2020) (0)
- Type II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate (2010) (0)
- The Use of FTICR-MS to Detect Chemical Tags from a Combinatorial Library (2003) (0)
- Proposed mechanism for ketopantoate hydroxymethyltransferase (2003) (0)
- Comparative Analysis of the Escherichia coli Ketopantoate Hydroxymethyltransferase Crystal Structure Confirms that It Is a Member of the ( (cid:2)(cid:3) ) 8 Phosphoenolpyruvate/Pyruvate Superfamily (2003) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and 2-pyrazol-1-ylbenzoic acid (2020) (0)
- Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with 1-(3-(1H-imidazol-1-yl)propyl)-3-((3s,5s,7s)-adamantan-1-yl)urea (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 11 (2-Amino-6-chloropurine) (2020) (0)
- Research data supporting “Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry” (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 18 (Isoxazole-5-carbothioamide) (2020) (0)
- Structure of P450 CYP121 in complex with lead compound MB286, 3-((1H-1,2,4-triazol-1-yl)methyl)aniline (2012) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 20 (6-Aminobenzothiazole) (2020) (0)
- A Single Molecule Study of Enzyme Inhibitor Interactions (2009) (0)
- Research Data Supporting "Achieving small–molecule disruption of the CK2α/CK2β protein–protein interaction within the protein kinase CK2 heterotetramer" (2016) (0)
- Serine 25 to Threonine mutation of aspartate decarboxylase (2003) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.75 Ang resolution in complex with 5'-deoxy-5'-((3-nitrobenzyl)disulfanyl)-adenosine (2009) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.05 Ang resolution- in complex with sulphonamide inhibitor 3 (2008) (0)
- Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS Salmon (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 26 (6-methoxybenzothiazole-2-carboxylic acid) (2020) (0)
- Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment 1 (0)
- Research data supporting "A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1" (2017) (0)
- Corrigendum: Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action (2017) (0)
- Research data supporting "Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles" (2018) (0)
- Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. (2023) (0)
- Crystal structure of Mycobacterium tuberculosis CYP121 in complex with LIG9 (2016) (0)
- Research data supporting "Insight into protein conformation and subcharging by DMSO from native ion mobility mass spectrometry" (2016) (0)
- Structural insights into the EthR-DNA interaction from native mass spectrometry (2016) (0)
- Structure of (–)-3-dehydroshikimic acid monohydrate (1988) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution (2017) (0)
- Pantothenate synthetase in complex with 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2013) (0)
- Research data supporting "Microcapsule Buckling Triggered by Compression-Induced Interfacial Phase Change" (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 17 (2H-1,3-Benzoxazine-2,4(3H)-dione) (2020) (0)
- Structure of cytochrome CYP121 in complex with 2-methylquinolin-6-amine (2012) (0)
- A Simple Method for the Preparation of 3-Hydroxyiminodehydroquinate, a Potent Inhibitor of Type II Dehydroquinase. (2003) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 27 (Methyl 2-(hydroxymethyl)-6H-thieno[2,3-b]pyrrole-5-carboxylate) (2020) (0)
- Induction of quorum sensing in microdroplets by transporting small molecule through PDMS (2010) (0)
- Humanised monomeric RadA in complex with napht-2-ol (2013) (0)
- Unexpected stability of aqueous dispersions of raspberry-like colloids (2018) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 2 (5-Amino-3-(2-thienyl) pyrazole) (2020) (0)
- Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents (2023) (0)
- Adventures with Atomic Force Microscopy (1999) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH FHAA TETRAPEPTIDE (2016) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 4 (5-Methoxybenzimidazole) (2020) (0)
- Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate (2006) (0)
- Pantothenate synthetase in complex with N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE (2013) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and N-(3-(aminomethyl)phenyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide (2020) (0)
- HumRadA22F in complex with compound 6 (2021) (0)
- Native precursor of pyruvoyl dependent Aspartate decarboxylase (2003) (0)
- Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution (2017) (0)
- Unprocessed Aspartate Decarboxylase Mutant, with Alanine inserted at position 24 (2003) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-((1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)sulfonyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and 2-(4-chloro-3-nitrobenzoyl)benzoic acid (2020) (0)
- Structure of Mycobacterium Tuberculosis Transcriptional Regulatory Repressor Protein (EthR) in complex with fragment 7E8. (2017) (0)
- Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate (2007) (0)
- HumRadA22F in complex with CAM833 (2021) (0)
- Design and structural analysis of aromatic inhibitors of type II dehydroquinate dehydratase from Mycobacterium tuberculosis - compound 49e [5-[(3-nitrobenzyl)amino]benzene-1,3-dicarboxylic acid] (2014) (0)
- The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide (2012) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form (2008) (0)
- MONOMERIC RADA IN COMPLEX WITH FATA TETRAPEPTIDE (2016) (0)
- Type II dehydroquinase from Mycobacterium tuberculosis complexed with citrazinic acid (2010) (0)
- RadA C-terminal ATPase domain from Pyrococcus furiosus bound to AMPPNP (2012) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(1H-indol-3-yl)acetamide (2019) (0)
- Research data supporting "Mass spectrometry reveals protein kinase CK2 high–order oligomerization via the circular trimeric assembly" (2016) (0)
- Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.6 Ang resolution in complex with fragment compound 5-methoxyindole, sulfate and glycerol (2009) (0)
- Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in a ternary complex with ATP and N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE (2013) (0)
- Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs. (2017) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-methylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
- Humanised monomeric RadA in complex with L-methylester tryptophan (2013) (0)
- Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 25 (6-Phenyl-3-pyridinyl)methylamine) (2020) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-phenylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
- Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator (N-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide) (2016) (0)
- Humanised monomeric RadA in complex with indazole (2013) (0)
- Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA (2016) (0)
- HumRadA2 in complex with Naphthyl-HPA fragment-peptide chimera (2021) (0)
- Towards engineering increased Pantothenate ( Vitamin B 5 ) levels in 1 plants 2 3 4 (2009) (0)
- Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-(3-chlorophenyl)propanoic acid (2020) (0)
- Crystal structure of the E. coli thiM riboswitch in complex with thiamine (2014) (0)
- HUMANISED MONOMERIC RADA IN COMPLEX WITH WHTA TETRAPEPTIDE (2016) (0)
- Synthesis of Tetrahydroquinolines, Hexahydrobenzoindolizines and an Aryl Phosphonate Linker for the Generation of Catalytic Antibodies. (1997) (0)
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What Schools Are Affiliated With Chris Abell?
Chris Abell is affiliated with the following schools: