Chris Abell

Chris Abell's AcademicInfluence.com Rankings

Chris Abell

Chemistry

#3446

World Rank

#4464

Historical Rank

Organic Chemistry

#547

World Rank

#632

Historical Rank

chemistry Degrees

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Chemistry

Chris Abell's Degrees

Bachelors Chemistry University of Oxford

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Chris Abell's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. (2010) (926)
Kinematical studies of the flows around free or surface-mounted obstacles; applying topology to flow visualization (1978) (678)
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge (2016) (670)
High-throughput crystallography for lead discovery in drug design (2002) (477)
Fragment-based approaches in drug discovery and chemical biology. (2012) (375)
One-Step Fabrication of Supramolecular Microcapsules from Microfluidic Droplets (2012) (351)
Quantitative detection of protein expression in single cells using droplet microfluidics. (2007) (343)
Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. (2009) (308)
Tough Supramolecular Polymer Networks with Extreme Stretchability and Fast Room‐Temperature Self‐Healing (2017) (282)
Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets. (2009) (243)
Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsions. (2010) (206)
Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance. (2008) (199)
Surface-induced droplet fusion in microfluidic devices. (2007) (193)
Development of quantitative cell-based enzyme assays in microdroplets. (2008) (188)
A reversible pH-driven DNA nanoswitch array. (2006) (185)
Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays. (2009) (181)
An Integrated Device for Monitoring Time‐Dependent in vitro Expression From Single Genes in Picolitre Droplets (2008) (176)
Direct and sensitive detection of a human virus by rupture event scanning (2001) (169)
Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. (2013) (166)
Biomimetic Supramolecular Polymer Networks Exhibiting both Toughness and Self‐Recovery (2017) (161)
Chiral discrimination by chemical force microscopy (1998) (158)
Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online. (2009) (157)
Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments. (2009) (155)
From microdroplets to microfluidics: selective emulsion separation in microfluidic devices. (2008) (153)
Cucurbit[n]uril-Based Microcapsules Self-Assembled within Microfluidic Droplets: A Versatile Approach for Supramolecular Architectures and Materials (2017) (151)
Writing with DNA and protein using a nanopipet for controlled delivery. (2002) (140)
A double droplet trap system for studying mass transport across a droplet-droplet interface. (2010) (138)
Evolution of enzyme catalysts caged in biomimetic gel-shell beads. (2014) (133)
Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. (2006) (131)
Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA. (2005) (131)
A compact functional quantum Dot-DNA conjugate: preparation, hybridization, and specific label-free DNA detection. (2008) (130)
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. (2009) (128)
Biosynthesis of pantothenate. (2004) (126)
Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry (2016) (124)
Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. (2006) (119)
A three-stage biophysical screening cascade for fragment-based drug discovery (2013) (117)
Using a Fragment-Based Approach To Target Protein–Protein Interactions (2013) (117)
Differentially Addressable Cavities within Metal-Organic Cage-Cross-Linked Polymeric Hydrogels. (2015) (116)
Experiences with the shikimate-pathway enzymes as targets for rational drug design. (2003) (115)
Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. (2012) (112)
Fragment-based approaches to enzyme inhibition. (2007) (102)
Fabrication of microgel particles with complex shape via selective polymerization of aqueous two-phase systems. (2012) (99)
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery (2013) (99)
Biosynthesis of pentalenene and pentalenolactone (1990) (94)
Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. (2009) (93)
Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing (1998) (91)
Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. (2003) (91)
Quantitative tracking of the growth of individual algal cells in microdroplet compartments. (2011) (91)
Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (2018) (90)
Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain (2013) (88)
An addressable antibody nanoarray produced on a nanostructured surface. (2004) (85)
An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets. (2009) (84)
Bioinspired supramolecular fibers drawn from a multiphase self-assembled hydrogel (2017) (84)
Escherichia coli L-aspartate-alpha-decarboxylase: preprotein processing and observation of reaction intermediates by electrospray mass spectrometry. (1997) (82)
Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. (2012) (75)
The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. (2002) (74)
Drugging challenging targets using fragment-based approaches. (2010) (73)
Interfacial assembly of dendritic microcapsules with host–guest chemistry (2014) (71)
Isolation and characterisation of a cDNA clone for a chlorophyll synthesis enzyme from Euglena gracilis. The chloroplast enzyme hydroxymethylbilane synthase (porphobilinogen deaminase) is synthesised with a very long transit peptide in Euglena. (1989) (71)
Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. (2014) (69)
Salicylate Biosynthesis: Overexpression, Purification, and Characterization of Irp9, a Bifunctional Salicylate Synthase from Yersinia enterocolitica (2005) (67)
Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. (2010) (67)
Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1** (2012) (66)
The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. (2001) (62)
Simultaneous measurement of reactions in microdroplets filled by concentration gradients. (2009) (62)
High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform (2015) (62)
Observation of an imine intermediate on dehydroquinase by electrospray mass spectrometry (1991) (62)
Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. (2004) (62)
Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum. (2014) (61)
Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases. (1996) (61)
Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identification (2012) (61)
Pantothenate biosynthesis in higher plants. (2005) (61)
Afm study on protein immobilization on charged surfaces at the nanoscale: Toward the fabrication of three-dimensional protein nanostructures (2003) (60)
SOLID PHASE ALDOL AND CONJUGATE ADDITION REACTIONS USING EVANS' OXAZOLIDINONE CHIRAL AUXILIARY (1998) (59)
Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding. (1991) (59)
Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry. (2013) (58)
Structural constraints on protein self‐processing in L‐aspartate‐α‐decarboxylase (2003) (58)
Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism. (2001) (57)
Binding of vancomycin group antibiotics to D-alanine and D-lactate presenting self-assembled monolayers. (2000) (56)
Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate (2008) (55)
Different mechanistic and stereochemical courses for the reactions catalysed by type I and type II dehydroquinases (1993) (55)
Direct and quantitative detection of bacteriophage by "hearing" surface detachment using a quartz crystal microbalance. (2001) (53)
From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1** (2011) (53)
Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support (1997) (51)
Calibration of AFM cantilever spring constants. (2003) (51)
Monitoring a reaction at submillisecond resolution in picoliter volumes. (2011) (51)
Supramolecular hydrogel microcapsules via cucurbit[8]uril host–guest interactions with triggered and UV-controlled molecular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01440a Click here for additional data file. (2015) (50)
The use of a dithiane protected benzoin photolabile safety catch linker for solid-phase synthesis (1997) (49)
A fragment-based approach to identifying ligands for riboswitches. (2010) (47)
Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate: Proof that the cyclization is catalyzed by a single enzyme (1984) (47)
Solution-phase synthesis of 2,6,9-trisubstituted purines (1998) (46)
Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites. (2003) (46)
Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors (2016) (45)
Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9. (1994) (45)
The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice). (1999) (45)
Unexpected stability of aqueous dispersions of raspberry-like colloids (2018) (45)
The design and synthesis of inhibitors of pantothenate synthetase. (2006) (45)
A nondestructive technique for determining the spring constant of atomic force microscope cantilevers (2001) (44)
A Fragment‐Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (2009) (44)
Supramolecular Nested Microbeads as Building Blocks for Macroscopic Self‐Healing Scaffolds (2018) (43)
Fragment screening against the thiamine pyrophosphate riboswitchthiM (2011) (43)
Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate. (2006) (43)
Escherichia coli dihydrodipicolinate synthase: characterization of the imine intermediate and the product of bromopyruvate treatment by electrospray mass spectrometry. (1995) (42)
Targeting a c-MYC G-quadruplex DNA with a fragment library. (2014) (42)
1.22 – Enzymology and Molecular Biology of the Shikimate Pathway (1999) (42)
Escherichia coli Chorismate Synthase Catalyzes the Conversion of (6S)-6-Fluoro-5-enolpyruvylshikimate-3-phosphate to 6-Fluorochorismate (1995) (41)
Label-free detection of DNA hybridization at the nanoscale: a highly sensitive and selective approach using atomic-force microscopy. (2003) (41)
Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly. (2006) (40)
Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis (2018) (40)
An Investigation into Solid-Phase Radical Chemistry - Synthesis of Furan Rings (2004) (40)
Selective Inhibition of Type II Dehydroquinases. (1999) (40)
Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6s)-6-fluoroshikimate. (2004) (38)
Fabrication of Three‐Dimensional Surface Structures with Highly Fluorescent Quantum Dots by Surface‐Templated Layer‐by‐Layer Assembly (2005) (38)
Reaction of (6R)-6-fluoroEPSP with recombinant Escherichia coli chorismate synthase generates a stable flavin mononucleotide semiquinone radical (1992) (36)
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain (2016) (36)
Fluorosurfactants for microdroplets: interfacial tension analysis. (2010) (36)
Enzymatic formation of lactams in organic solvents (1992) (36)
Label-Free Analysis and Sorting of Microalgae and Cyanobacteria in Microdroplets by Intrinsic Chlorophyll Fluorescence for the Identification of Fast Growing Strains. (2016) (36)
Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme (1993) (35)
Supramolecular colloidosomes: fabrication, characterisation and triggered release of cargo. (2014) (35)
Mechanistic and inhibition studies of chorismate-utilizing enzymes. (2005) (35)
Controlling the contents of microdroplets by exploiting the permeability of PDMS. (2011) (34)
Microdroplet fabrication of silver–agarose nanocomposite beads for SERS optical accumulation (2011) (34)
Single molecule fluorescence under conditions of fast flow. (2012) (34)
Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. (2010) (34)
Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases (2014) (34)
Electrostatically Directed Self-Assembly of Ultrathin Supramolecular Polymer Microcapsules (2015) (34)
Posttranslational modification of Klebsiella pneumoniae flavodoxin by covalent attachment of coenzyme A, shown by 31P NMR and electrospray mass spectrometry, prevents electron transfer from the nifJ protein to nitrogenase. A possible new regulatory mechanism for biological nitrogen fixation. (1992) (34)
Studies with Substrate and Cofactor Analogues Provide Evidence for a Radical Mechanism in the Chorismate Synthase Reaction* (2000) (32)
Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors (2007) (32)
Crystal Structure of Escherichia coli Ketopantoate Reductase in a Ternary Complex with NADP+ and Pantoate Bound (2007) (32)
The sequence of hemC, hemD and two additional E. coli genes. (1988) (32)
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. (2011) (32)
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site (2016) (32)
Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids (1997) (31)
A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection. (2011) (31)
The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. (2005) (31)
Purification, characterization, crystallisation and X-ray analysis of selenomethionine-labelled hydroxymethylbilane synthase from Escherichia coli. (1993) (31)
Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS. (2016) (30)
The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations (2014) (30)
Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121 (2013) (29)
Inhibition studies on salicylate synthase. (2005) (29)
Uroporphyrinogen III synthase: Studies on its mechanism of action, molecular biology and biochemistry (1991) (29)
Evidence for opposite stereochemical courses for the reaction catalysed by type I and type II dehydrocquinases (1993) (29)
High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay** (2012) (28)
Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets. (2012) (28)
Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams (2010) (28)
Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification (2010) (28)
Method to determine the spring constant of atomic force microscope cantilevers (2004) (28)
Management of the diffusion of 4‐methylumbelliferone across phases in microdroplet‐based systems for in vitro protein evolution (2010) (27)
Observation of an isotope effect in the chorismate synthase reaction (1990) (27)
A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR. (2014) (27)
Microfluidic Droplet-Facilitated Hierarchical Assembly for Dual Cargo Loading and Synergistic Delivery (2015) (27)
Formation of Cucurbit[8]uril-Based Supramolecular Hydrogel Beads Using Droplet-Based Microfluidics. (2015) (27)
Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues. (2012) (27)
MicroRNA-specific argonaute 2 protein inhibitors. (2013) (26)
Role of Surface Perfection in Chemical Force Microscopy. (1998) (26)
Inhibition of chorismate synthase by (6R)- and (6S)-6-fluoro-5-enolpyruvylshikimate 3-phosphate (1991) (26)
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding. (2017) (26)
The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions. (2015) (26)
Pantothenate biosynthesis in higher plants: advances and challenges (2006) (25)
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping (2019) (25)
Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. (1991) (25)
Patterned Arrays of Supramolecular Microcapsules (2018) (25)
Intra-Species Bacterial Quorum Sensing Studied at Single Cell Level in a Double Droplet Trapping System (2013) (24)
Droplet-based microfluidic analysis and screening of single plant cells (2017) (23)
Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis (2015) (23)
Synthesis of (2R)-2-bromodehydroquinic acid and(2R)-2-fluorodehydroquinicacid (1997) (23)
Real Time Dual-Channel Multiplex SERS Ultradetection. (2014) (23)
Combinatorial synthetic design. (1999) (23)
Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy. (2006) (22)
Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. (2009) (22)
ENZYMATIC SYNTHESIS OF (6R)- AND (6S)-FLUOROSHIKIMIC ACIDS (1995) (22)
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches (2019) (22)
Enzyme synthesis and activity assay in microfluidic droplets on a chip (2011) (22)
Nanomolar Inhibition of Type II Dehydroquinase Based on the Enolate Reaction Mechanism (2007) (22)
2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site. (2019) (21)
Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach (2017) (21)
Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases (2007) (21)
Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli. (1986) (21)
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays (2016) (21)
A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines (1999) (21)
Lipophilic modification of oligonucleotides (1997) (21)
Chemical force microscopy with active enzymes. (2001) (20)
Specificity of E. Coli shikimate dehydrogenase towards analogues of 3-dehydroshikimic acid (1988) (20)
Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking. (2014) (20)
A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine Peptide Library (1997) (20)
Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase. (2003) (19)
Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis (2015) (19)
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. (2004) (19)
The biochemical properties of the two Arabidopsis thaliana isochorismate synthases (2017) (18)
Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors (2019) (18)
Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction (2001) (18)
Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase. (2003) (18)
Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches. (2011) (18)
Fragment-based approaches to TB drugs (2016) (17)
Escherichia coli chorismate synthase: a deuterium kinetic-isotope effect under single-turnover and steady-state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved. (1995) (17)
Structural insights into the evolution of the pantothenate-biosynthesis pathway. (2003) (17)
Structural insights into the EthR-DNA interaction using native mass spectrometry. (2017) (17)
Dual-responsive supramolecular colloidal microcapsules from cucurbit[8]uril molecular recognition in microfluidic droplets (2016) (16)
Inhibition of Ral GTPases Using a Stapled Peptide Approach* (2016) (16)
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death (2020) (16)
Observation of a secondary tritium isotope effect in the chorismate synthase reaction. (1995) (16)
Rv2607 from Mycobacterium tuberculosis Is a Pyridoxine 5′-Phosphate Oxidase with Unusual Substrate Specificity (2011) (16)
A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters (1999) (16)
Droplet-based microfluidic screening and sorting of microalgal populations for strain engineering applications☆ (2021) (15)
Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions. (2013) (15)
Applications of Microdroplet Technology for Algal Biotechnology (2016) (15)
Tri-partite complex for axonal transport drug delivery achieves pharmacological effect (2010) (15)
Mass Spectrometry Reveals Protein Kinase CK2 High-Order Oligomerization via the Circular and Linear Assembly. (2016) (15)
The use of 2H n.m.r. spectroscopy and β-isotopic shifts in the 13C n.m.r. spectrum to measure deuterium retention in the biosynthesis of the polyketide 6-methylsalicylic acid (1981) (15)
Synthesis of 2-Bromo- and 2-Fluoro-3-dehydroshikimic Acids and 2-Bromo- and 2-Fluoroshikimic Acids Using Synthetic and Enzymatic Approaches (1998) (15)
Mass spectrometry for fragment screening. (2017) (15)
The use of trichloroacetimidate-activated resin for ester formation (1998) (15)
Design and synthesis of aromatic inhibitors of anthranilate synthase. (2005) (15)
Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate. Anti stereochemistry in a biological SE' reaction (1988) (15)
Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. (2010) (14)
Influence of the foundation layer on the layer-by-layer assembly of poly-L-lysine and poly(styrenesulfonate) and its usage in the fabrication of 3D microscale features. (2004) (14)
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1* (2016) (14)
Investigating the specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single-molecule force spectroscopy. (2007) (14)
Pantothenic Acid Biosynthesis in the Parasite Toxoplasma gondii: a Target for Chemotherapy (2014) (14)
How Much Chemistry is There in Chemical Force Microscopy? (1999) (14)
2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action. (2019) (14)
Evidence for consecutive 1,2-alkyl shifts in sterpurene biosynthesis: isolation and characterisation of 7,12-dihydroxysterpurene (1987) (14)
Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics. (2020) (14)
Microcapsule Buckling Triggered by Compression-Induced Interfacial Phase Change. (2016) (14)
Viscoelastic Hydrogel Microfibers Exploiting Cucurbit[8]uril Host–Guest Chemistry and Microfluidics (2020) (14)
Novel chemical tagging method for combinatorial synthesis utilizing suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry. (2001) (14)
Disrupting the Constitutive, Homodimeric Protein–Protein Interface in CK2β Using a Biophysical Fragment-Based Approach (2016) (14)
Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine. (1990) (14)
Vinyl fluoride as an isoelectronic replacement for an enolate anion: inhibition of type II dehydroquinases. (2002) (14)
Detection of Covalent Intermediates Formed in the Reaction of 4‐Amino‐4‐deoxychorismate Synthase (2005) (14)
Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors (2016) (14)
Towards engineering increased pantothenate (vitamin B5) levels in plants (2008) (14)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification (2019) (14)
Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites. (2003) (13)
The absolute stereochemistry of the enzymic cyclisation to form the sterpurene sesquiterpenes (1988) (13)
Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase. (2000) (13)
Affinity labelling of E. coli dehydroquinase (1988) (13)
Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis. (2016) (12)
Insight into Protein Conformation and Subcharging by DMSO from Native Ion Mobility Mass Spectrometry (2016) (12)
Biosynthesis of the fungal metabolites alternariol, mellein, rubrofusarin, and 6-methylsalicylic acid from CD3CO2H (1982) (12)
Ligand‐Observed NMR in Fragment‐Based Approaches (2012) (12)
Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation. (2014) (12)
Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis (2016) (12)
Bioinspired hydrogel microfibres colour-encoded with colloidal crystals (2019) (12)
Evidence for the pathway to pantothenate in plants (1994) (12)
Differential Scanning Fluorimetry as Part of a Biophysical Screening Cascade (2016) (12)
Coenzyme biosynthesis: enzyme mechanism, structure and inhibition. (2007) (11)
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis (2021) (11)
Rational design of new bifunctional inhibitors of type II dehydroquinase. (2005) (11)
Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design (2015) (11)
Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids. (2000) (11)
Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). (1989) (11)
Discovery of Schaeffer’s Acid Analogues as Lead Structures of Mycobacterium tuberculosis Type II Dehydroquinase Using a Rational Drug Design Approach (2013) (11)
Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy. (2010) (11)
Structure‐activity relationship of the peptide binding‐motif mediating the BRCA2:RAD51 protein–protein interaction (2016) (11)
Systematic manipulation of surface chemical reaction on the nanoscale: a novel approach for constructing three-dimensional nanostructures. (2003) (10)
Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis. (2005) (10)
Surface-immobilised micelles via cucurbit[8]uril-rotaxanes for solvent-induced burst release. (2015) (10)
pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study (2007) (10)
Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxy-dehydroquinic acid (1996) (9)
Derailing Dehydroquinate Synthase by Introducing a Stabilizing Stereoelectronic Effect in a Reaction Intermediate. (1997) (9)
Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate. (2001) (9)
Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry. (2017) (9)
Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode. (2019) (9)
Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies (1997) (9)
Design and synthesis of aromatic inhibitors of anthranilate synthase. (2005) (9)
Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach. (2016) (9)
Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia). (2003) (9)
Preparation of Symmetrical and Unsymmetrical DNA–Protein Conjugates with DNA as a Molecular Scaffold (2001) (8)
Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action (2017) (8)
A Convenient Method for the Synthesis of Dehydroquinic Acid (2003) (8)
Focused surface acoustic waves induced microdroplets generation and its application for microgels (2019) (8)
Chiral discrimination of basic and hydrophobic molecules by chemical force spectroscopy. (2003) (8)
Design and Structural Analysis of Aromatic Inhibitors of Type II Dehydroquinase from Mycobacterium tuberculosis (2015) (8)
Nucleophile Selectivity of Chorismate‐Utilizing Enzymes (2007) (8)
The Stability of Polyuridylic Acid in Acid Solution (1965) (8)
Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51 (2016) (8)
Motile Artificial Chromatophores: Light‐Triggered Nanoparticles for Microdroplet Locomotion and Color Change (2019) (7)
Biosynthesis of the pigments of life: Structure and mode of action of a novel enzymatic cofactor (1989) (7)
Biosynthesis of the polyketide mellein from CD3CO2H and 13CD3CO2H in Aspergillus melleus: detection of deuterium by 2H n.m.r. and edited 13C n.m.r. spectra (1983) (7)
The synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-enolpyruvylshikimate-3-phosphate (1991) (7)
Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. (2020) (7)
Supracolloidal Architectures Self-Assembled in Microdroplets. (2015) (7)
Single-step biocompatible coating for sulfhydryl coupling of receptors using 2-(pyridinyldithio)ethylcarbamoyl dextran. (2008) (7)
The absolute configuration of the sterpurene sesquiterpenes (1988) (7)
An amino acid sequence motif observed amongst enzymes of the shikimate pathway. (1991) (7)
Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126 (2014) (7)
Biosynthesis of 6-methylsalicylic acid; the combined use of mono- and tri-duteriated acetate precursors to investigate the degree of stereocontrol in the aromatisation sequence (1984) (7)
Biomimetic syntheses of the polyketide fungal metabolites alternariol and rubrofusarin: models for cyclisation reactions catalysed by polyketide synthase enzymes (1986) (6)
A novel phase-switching protecting group for multi-step parallel solution phase synthesis. (2004) (6)
Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes. (2006) (6)
Construction of core-shell microcapsules via focused surface acoustic wave microfluidics. (2020) (6)
Small-Molecule Inhibitors That Target Protein – Protein Interactions in the RAD 51 Family of Recombinases (2015) (6)
Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase (2014) (6)
A novel anthracenyl tagged protecting group for "phase-switching" applications in parallel synthesis. (2003) (6)
A simple method for the preparation of 3-hydroxyiminodehydroquinate, a potent inhibitor of type II dehydroquinase (2002) (6)
Structure of (–)-quinic acid (1988) (6)
Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. (2012) (6)
Synthesis of 4-deoxyquinic, 4-deoxyshikimic and 4-deoxy-3-dehydroshikimic acids (1999) (6)
Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. (2001) (6)
Comparative Analysis of the Escherichia coli Ketopantoate Hydroxymethyltransferase Crystal Structure Confirms that It Is a Member of the (βα)8 Phosphoenolpyruvate/Pyruvate Superfamily (2003) (6)
The resolution of diterpene cyclase activities from Ricinus communis (1994) (6)
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1. (2017) (6)
Microdroplets confined assembly of opal composites in dynamic borate ester-based networks (2020) (5)
Fragment-Based Drug Discovery (2015) (5)
Cucurbit[7]uril-based high-performance catalytic microreactors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/C8NR02900H (2018) (5)
Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice (2018) (4)
The Use of NMR Spectroscopy to Follow Deuterium in Studies of Fungal Metabolism (1986) (4)
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site (2019) (4)
Fragment-based drug discovery in academia: Experiences from a tuberculosis programme (2009) (4)
AN ELECTROCHEMICAL STUDY TO MODEL THE CHORISMATE SYNTHASE REACTION (1996) (4)
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site (2021) (4)
Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics (2020) (4)
Research data supporting "Supramolecular hydrogel microcapsules via cucurbit[8]uril host–guest interactions with triggered and UV-controlled molecular permeability" (2015) (3)
Chapter 16:Discovery and Extrapolation of Fragment Structures towards Drug Design (2007) (3)
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach. (2022) (3)
Enzymes that exploit imines--one way or the other. (1998) (3)
The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis (2000) (3)
Structural Insights into Escherichia coli Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometry. (2019) (3)
Studies on the biosynthesis of hydroxymellein using 17O n.m.r. and 2H n.m.r. spectroscopy to determine the origin of the C-4 hydroxy group (1987) (3)
ATP half‐sites in RadA and RAD51 recombinases bind nucleotides (2016) (3)
Use of Quinic Acid as Template in Solid-Phase Combinatorial Synthesis (1999) (2)
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) (2022) (2)
CHAPTER 1:Different Flavours of Fragments (2015) (2)
Successful use of axonal transport for drug delivery by synthetic molecular vehicles (2008) (2)
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. (2022) (2)
Sensitive and direct detection using rupture event scanning (REVS/spl trade/) (2002) (2)
Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference (2020) (2)
Comparative study of the protection of modified and unmodified dsDNA by cationic and non-cationic lipids and liposomes to digestion by DNase I (1998) (2)
Approaches to Antibody-Catalyzed Cationic Cyclizations: Chemical Studies of Leaving Groups and Cyclization Modes (1996) (2)
Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility (2021) (2)
Enzymic synthesis of 3-[3- 13C]dehydroquinic acid. (2003) (2)
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design (2022) (2)
Solution-Phase Synthesis of 2,6,9-Trisubstituted Purines. (1998) (1)
The use of FTICR-MS to detect chemical tags from a combinatorial library. (2002) (1)
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity (2021) (1)
Synthesis of (2R)-2-Bromodehydroquinic Acid and (2R)-2- Fluorodehydroquinic Acid. (1997) (1)
Design and synthesis of transition-state analogues for a cationic cyclisation (1994) (1)
Novel selenium containing non-detergent sulphobetaines (2003) (1)
Research data supporting “Dual-responsive supramolecular colloidal microcapsules from cucurbit[8]uril molecular recognition in microfluidic droplets” (2016) (1)
Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH). (2019) (1)
Crystal structure of ketopantoate reductase in complex with NADP (2005) (1)
Crystal structure of pantothenate synthetase in complex with 2-(2-(benzofuran-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid (2009) (1)
Combinatorial Synthetic Design (1999) (1)
Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics (2022) (1)
Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections (2022) (1)
Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis (2020) (1)
Novel Selenium‐Containing Non‐Detergent Sulfobetaines. (2004) (1)
Structure of sodium (–)‐shikimate dihydrate (1988) (1)
Type II Dehydroquinase from Mycobacterium tuberculosis complexed with 2,3-anhydro-quinic acid (2003) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 22 at 1.84A resolution (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 22 (Ethyl 1H-pyrazole-4-carboxylate) (2020) (0)
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in apo form (2021) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 15 (6-quinoxalinamine) (2020) (0)
Structure of humanised RadA-mutant humRadA22F in complex with 1-Indane-6-carboxylic acid (2016) (0)
Crystal Structure of Ketopantoate Hydroxymethyltransferase complexed the Product Ketopantoate (2003) (0)
HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE (2016) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 1 at 1.63A resolution (2016) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with (E)-3-(furan-3-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one at 1.78A resolution (2017) (0)
HumRadA33F in complex with peptidic inhibitor 6 (2021) (0)
Fragment-based approaches for anti-tuberculosis drug discovery (2013) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide (2012) (0)
Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with Histidine 11 Mutated to Alanine (2003) (0)
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with ATP (2021) (0)
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTU TETRAPEPTIDE (2016) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.40 Ang resolution in complex with fragment compound 1-Benzofuran-2-carboxylic acid (2009) (0)
Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-[3-(trifluoromethyl)phenyl]prop-2-enoic acid (2020) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
Pantothenate synthetase in complex with racemate (2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID and (2R)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID (2013) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acid (2009) (0)
Unliganded form of Polo-like kinase I Polo-box domain (2011) (0)
ketopantoate reductase: a structural and calorimetric study (2007) (0)
Humanised monomeric RadA in complex with FHTA tetrapeptide (2013) (0)
CRYSTAL APO-STRUCTURE OF PANTOTHENATE SYNTHETASE FROM E. COLI (2001) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with S-Adenosyl methionine (2020) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-((tetrahydrofuran-3-yl)methyl)pyrrolidine-1-carboxamide at 1.93A resolution (2017) (0)
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor (0)
T. maritima ThyX in complex with TyC5-03 (2016) (0)
3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with 3-hydroxyimino-quinic acid (2003) (0)
Ketopantoate Reductase from Escherichia coli (2002) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 16 (2-Amino-3-nitropyridine) (2020) (0)
A Convenient Method for the Synthesis of Dehydroquinic Acid. (2003) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 12 (2-Aminobenzothiazole) (2020) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 10 (2-Amino-5-bromobenzothiazole) (2020) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 8 (3-[(2-thienylthio)methyl]benzoic acid) (2020) (0)
Development of potent inhibitors by fragment‐linking strategies (2022) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 2 at 1.68A resolution (2016) (0)
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment 2 (0)
Surface flexibility of Plk1 – implications in substrate binding and drug design (2011) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 1 (1H-Indole-5-carboxamide) (2020) (0)
Research data supporting “Label-free analysis and sorting of microalgae and cyanobacteria in microdroplets by intrinsic chlorophyll fluorescence for the identification of fast growing strain” (2016) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 28 at 1.99A resolution (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 14 (Methyl 2-aminopyridine-4-carboxylate) (2020) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.80 Ang resolution in complex with 5'-deoxy-5'-thioadenosine (2009) (0)
Polo-like kinase I Polo-box domain in complex with FMPPPMSpSM phosphopeptide from TCERG1 (2011) (0)
RadA C-terminal ATPase domain from Pyrococcus furiosus (2012) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 9 (Adenine) (2020) (0)
Processed Aspartate Decarboxylase Mutant with Ser25 mutated to Cys (2003) (0)
Mycobacterium tuberculosis protein Rv1155 in complex with co-enzyme F420 (2015) (0)
Polo-like kinase I Polo-box domain in complex with MQSpSPL phosphopeptide (2011) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution (2016) (0)
Crystal structure of the E. coli thiM riboswitch in complex with thieno[2,3-b]pyrazin-7-amine (2014) (0)
n of CK 2 a from an anchor outside the active site † (2016) (0)
Design and structural analysis of aromatic inhibitors of type II dehydroquinase dehydratase from Mycobacterium tuberculosis - compound 35c [3,4-dihydroxy-5-(3-nitrophenoxy)benzoic acid] (2014) (0)
Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-Methoxy-N-(5-methylpyridin-2-ylsulfonyl)-1H-indole-2-carboxamide (2009) (0)
A simple method for the preparation of 3-hydroxyiminodehydroquinate,The IUPAC name for 3-hydroxyiminodehydroquinate is (1S,4R,5R)-1,4,5-trihydroxy-3-(hydroxyimino)cyclohexane-1-carboxylate. a potent inhibitor of type II dehydroquinase (2002) (0)
Biosynthesis of Pantothenate (2005) (0)
T57V mutant of aspartate decarboxylase (2012) (0)
Systematic manipulation of surfaces by sequential nanoscale chemical reactions: a novel approach for constructing three dimensional nanostructures (2003) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 21 (2-Amino-3-nitrophenol) (2020) (0)
Research data supporting "A fragment-based approach to targeting IMPDH from Mycobacterium tuberculosis" (2018) (0)
Preparation of molecular arrays (2002) (0)
A sensitive and economical method to directly detect particles (2002) (0)
Cell Based Biological Assay Using Microfluidics (2008) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azocan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
Synthesis of 4-Deoxyquinic, 4-Deoxyshikimic and 4-Deoxy-3-dehydroshikimic Acid. (1999) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 5 (Isoxazole-5-carboxamide) (2020) (0)
Processed Aspartate Decarboxylase Mutant with Asn72 mutated to Ala (2012) (0)
Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (2018) (0)
Enzymatic Formation of Lactams in Organic Solvents. (1992) (0)
Crystal structure of the E. coli thiM riboswitch in complex with hypoxanthine (2014) (0)
Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells. (2022) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 6 (2-(1,3-oxazol-5-yl) aniline) (2020) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 24 (Indole-6-boronic acid) (2020) (0)
PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE (1998) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.95 Ang resolution in complex with 5'-deoxy-5'-((R)-3,4-dihydroxybutylthio)-adenosine (2009) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid (2010) (0)
RSC_IB_C1IB00033K 1..9 (2011) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 5 at 1.57A resolution (2016) (0)
Addressable Macroscopic 2D networks self-assembled from nanometre size protein/DNA complexes (2006) (0)
Apo-structure of humanised RadA-mutant humRadA22F (2016) (0)
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHPA TETRAPEPTIDE (2016) (0)
Supplementary material from "Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping" (2019) (0)
Crystal structure of the E. coli thiM riboswitch in complex with (4-(1,2,3-thiadiazol-4-yl)phenyl)methanamine (2014) (0)
Coenzyme Biosynthesis: Enzyme Mechanism, Structure and Inhibition (2008) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide (2012) (0)
Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-hydroxynaphthalene-2-carboxylic acid (2020) (0)
Crystal structure of 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with inhibitor 2 (2011) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 13 (4-Hydroxyquinazoline) (2020) (0)
Kinetics of protein expression in single cells using microfluidics (2008) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(quinolin-4-yl)acetamide (2019) (0)
Crystal structure of Yersinia enterocolitica salicylate synthase (Irp9) (2006) (0)
Research data supporting 'Wu et al., Bioinspired supramolecular fibers drawn from a multi-phase self-assembled hydrogel, PNAS, 2017' (2018) (0)
Wales Andrew Wheatley Paul Wood Peter Wothers Dominic Wright An introduction to Cambridge Chemistry Academic staff (2012) (0)
Crystal structure of the E. coli thiM riboswitch in complex with 5-(azidomethyl)-2-methylpyrimidin-4-amine (2014) (0)
Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors (2017) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor (2019) (0)
Research Data Supporting "Substrate fragmentation for the design of M. tuberculosis CYP121 inhibitors" (2016) (0)
Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (2022) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 3 at 1.84A resolution (2016) (0)
Pink Doesn’t Exist! - A Tale of Trophoblast Differentiation (2017) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 15 at 1.76A resolution (2016) (0)
Humanised monomeric RadA in complex with 5-methyl indole (2013) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 19 (5-fluoroquinazolin-4-ol) (2020) (0)
Structure of CYP121 in complex with 4-(4-phenoxy-1H-pyrazol-3-yl)benzene-1,3-diol (2012) (0)
Research data supporting "Supramolecular nested microbeads as building blocks for macroscopic self-healing scaffolds" (2018) (0)
S25A mutant of pyruvoyl dependent aspartate decarboxylase (2003) (0)
Humanised monomeric RadA in complex with 5-hydroxy indole (2013) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 21 at 1.7A resolution (2016) (0)
Structure of cytochrome P450 CYP121 in complex with 4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylate (2012) (0)
Structure of cytochrome P450 CYP121 in complex with 4-(1H-1,2,4-triazol-1-yl)phenol (2012) (0)
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target. (2023) (0)
Palladium‐Catalyzed Carbon–Carbon Bond Formation on Solid Support (2002) (0)
Research data supporting "Structural insights into the EthR-DNA interaction using native mass spectrometry" (2017) (0)
Glycine 24 to Serine mutation of aspartate decarboxylase (2003) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 7 (2-Amino-6-fluorobenzothiazole) (2020) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 23 (3-Amino-5-(4-methoxyphenyl)pyrazole) (2020) (0)
Humanised monomeric RadA in complex with napht-1-ol (2013) (0)
Probing cell to cell variations in gene expression using microfluidics (2009) (0)
Type II Dehydroquinase inhibitor complex (2006) (0)
Polo-like kinase I Polo-box domain in complex with FDPPLHSpTA phosphopeptide from PBIP1 (2011) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 4 at 1.87A resolution (2016) (0)
MEGAHERTZ-GENERATED FEMTOLITER MICROFLUIDIC DROPLETS FOR SINGLE-MOLECULE-COUNTING IMMUNOASSAY (2013) (0)
Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors (2020) (0)
Regioselective Conversion of Arenes to N-Aryl-1,2,3-triazoles Using C—H Borylation. (2015) (0)
Humanised monomeric RadA in complex with 2-amino benzothiazole (2013) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate (2016) (0)
Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1 (2013) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-(cyclopentylmethyl)pyrrolidine-1-carboxamide at 1.77A resolution (2017) (0)
Humanised monomeric RadA in complex with 4-methylester indole (2013) (0)
Inside Cover: A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009) (2009) (0)
Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) (2021) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 3 (2-(5-Isoxazolyl) phenol) (2020) (0)
Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with an Alanine insertion at position 26 (2003) (0)
Syntheses of 2‐Bromo‐ and 2‐Fluoro‐3‐dehydroshikimic Acids and 2‐Bromo‐ and 2‐Fluoroshikimic Acids Using Synthetic and Enzymatic Approaches. (1998) (0)
Studies on the Synthesis, Characterization and Reactivity of Aromatic Diboronic Acids. (1997) (0)
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTG TETRAPEPTIDE (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in Apo form (2020) (0)
Type II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate (2010) (0)
The Use of FTICR-MS to Detect Chemical Tags from a Combinatorial Library (2003) (0)
Proposed mechanism for ketopantoate hydroxymethyltransferase (2003) (0)
Comparative Analysis of the Escherichia coli Ketopantoate Hydroxymethyltransferase Crystal Structure Conﬁrms that It Is a Member of the ( (cid:2)(cid:3) ) 8 Phosphoenolpyruvate/Pyruvate Superfamily (2003) (0)
Crystal structure of M. tuberculosis InhA in complex with NAD+ and 2-pyrazol-1-ylbenzoic acid (2020) (0)
Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with 1-(3-(1H-imidazol-1-yl)propyl)-3-((3s,5s,7s)-adamantan-1-yl)urea (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 11 (2-Amino-6-chloropurine) (2020) (0)
Research data supporting “Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry” (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 18 (Isoxazole-5-carbothioamide) (2020) (0)
Structure of P450 CYP121 in complex with lead compound MB286, 3-((1H-1,2,4-triazol-1-yl)methyl)aniline (2012) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 20 (6-Aminobenzothiazole) (2020) (0)
A Single Molecule Study of Enzyme Inhibitor Interactions (2009) (0)
Research Data Supporting "Achieving small–molecule disruption of the CK2α/CK2β protein–protein interaction within the protein kinase CK2 heterotetramer" (2016) (0)
Serine 25 to Threonine mutation of aspartate decarboxylase (2003) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.75 Ang resolution in complex with 5'-deoxy-5'-((3-nitrobenzyl)disulfanyl)-adenosine (2009) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.05 Ang resolution- in complex with sulphonamide inhibitor 3 (2008) (0)
Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS Salmon (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 26 (6-methoxybenzothiazole-2-carboxylic acid) (2020) (0)
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment 1 (0)
Research data supporting "A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1" (2017) (0)
Corrigendum: Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action (2017) (0)
Research data supporting "Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles" (2018) (0)
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. (2023) (0)
Crystal structure of Mycobacterium tuberculosis CYP121 in complex with LIG9 (2016) (0)
Research data supporting "Insight into protein conformation and subcharging by DMSO from native ion mobility mass spectrometry" (2016) (0)
Structural insights into the EthR-DNA interaction from native mass spectrometry (2016) (0)
Structure of (–)-3-dehydroshikimic acid monohydrate (1988) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution (2017) (0)
Pantothenate synthetase in complex with 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2013) (0)
Research data supporting "Microcapsule Buckling Triggered by Compression-Induced Interfacial Phase Change" (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 17 (2H-1,3-Benzoxazine-2,4(3H)-dione) (2020) (0)
Structure of cytochrome CYP121 in complex with 2-methylquinolin-6-amine (2012) (0)
A Simple Method for the Preparation of 3-Hydroxyiminodehydroquinate, a Potent Inhibitor of Type II Dehydroquinase. (2003) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 27 (Methyl 2-(hydroxymethyl)-6H-thieno[2,3-b]pyrrole-5-carboxylate) (2020) (0)
Induction of quorum sensing in microdroplets by transporting small molecule through PDMS (2010) (0)
Humanised monomeric RadA in complex with napht-2-ol (2013) (0)
Unexpected stability of aqueous dispersions of raspberry-like colloids (2018) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 2 (5-Amino-3-(2-thienyl) pyrazole) (2020) (0)
Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents (2023) (0)
Adventures with Atomic Force Microscopy (1999) (0)
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHAA TETRAPEPTIDE (2016) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 4 (5-Methoxybenzimidazole) (2020) (0)
Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate (2006) (0)
Pantothenate synthetase in complex with N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE (2013) (0)
Crystal structure of M. tuberculosis InhA in complex with NAD+ and N-(3-(aminomethyl)phenyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide (2020) (0)
HumRadA22F in complex with compound 6 (2021) (0)
Native precursor of pyruvoyl dependent Aspartate decarboxylase (2003) (0)
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution (2017) (0)
Unprocessed Aspartate Decarboxylase Mutant, with Alanine inserted at position 24 (2003) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-((1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)sulfonyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
Crystal structure of M. tuberculosis InhA in complex with NAD+ and 2-(4-chloro-3-nitrobenzoyl)benzoic acid (2020) (0)
Structure of Mycobacterium Tuberculosis Transcriptional Regulatory Repressor Protein (EthR) in complex with fragment 7E8. (2017) (0)
Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate (2007) (0)
HumRadA22F in complex with CAM833 (2021) (0)
Design and structural analysis of aromatic inhibitors of type II dehydroquinate dehydratase from Mycobacterium tuberculosis - compound 49e [5-[(3-nitrobenzyl)amino]benzene-1,3-dicarboxylic acid] (2014) (0)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide (2012) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form (2008) (0)
MONOMERIC RADA IN COMPLEX WITH FATA TETRAPEPTIDE (2016) (0)
Type II dehydroquinase from Mycobacterium tuberculosis complexed with citrazinic acid (2010) (0)
RadA C-terminal ATPase domain from Pyrococcus furiosus bound to AMPPNP (2012) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(1H-indol-3-yl)acetamide (2019) (0)
Research data supporting "Mass spectrometry reveals protein kinase CK2 high–order oligomerization via the circular trimeric assembly" (2016) (0)
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.6 Ang resolution in complex with fragment compound 5-methoxyindole, sulfate and glycerol (2009) (0)
Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in a ternary complex with ATP and N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE (2013) (0)
Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs. (2017) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-methylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
Humanised monomeric RadA in complex with L-methylester tryptophan (2013) (0)
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 25 (6-Phenyl-3-pyridinyl)methylamine) (2020) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-phenylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (2019) (0)
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator (N-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide) (2016) (0)
Humanised monomeric RadA in complex with indazole (2013) (0)
Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA (2016) (0)
HumRadA2 in complex with Naphthyl-HPA fragment-peptide chimera (2021) (0)
Towards engineering increased Pantothenate ( Vitamin B 5 ) levels in 1 plants 2 3 4 (2009) (0)
Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-(3-chlorophenyl)propanoic acid (2020) (0)
Crystal structure of the E. coli thiM riboswitch in complex with thiamine (2014) (0)
HUMANISED MONOMERIC RADA IN COMPLEX WITH WHTA TETRAPEPTIDE (2016) (0)
Synthesis of Tetrahydroquinolines, Hexahydrobenzoindolizines and an Aryl Phosphonate Linker for the Generation of Catalytic Antibodies. (1997) (0)

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What Schools Are Affiliated With Chris Abell?

Chris Abell is affiliated with the following schools:

University of Oxford
Stanford University
University of Cambridge