Chris Goodnow | Academic Influence

Chris Goodnow's AcademicInfluence.com Rankings

Chris Goodnow

Computer Science

#3900

World Rank

#4098

Historical Rank

#1386

USA Rank

Machine Learning

#804

World Rank

#815

Historical Rank

#86

USA Rank

Artificial Intelligence

#1013

World Rank

#1031

Historical Rank

#190

USA Rank

Database

#1522

World Rank

#1597

Historical Rank

#398

USA Rank

computer-science Degrees

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Computer Science

Chris Goodnow's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Why Is Chris Goodnow Influential?

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According to Wikipedia, Christopher Carl Goodnow is an immunology researcher and the current executive director of the Garvan Institute of Medical Research. He holds the Bill and Patricia Ritchie Foundation Chair and is a Conjoint Professor in the faculty of medicine at UNSW Sydney. He holds dual Australian and US citizenship.

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Chris Goodnow's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling (2015) (2129)
Differential activation of transcription factors induced by Ca2+ response amplitude and duration (1997) (1951)
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice (1988) (1449)
C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity (1996) (1227)
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity (2005) (839)
Aire regulates negative selection of organ-specific T cells (2003) (806)
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens (1991) (755)
Cellular and genetic mechanisms of self tolerance and autoimmunity (2005) (695)
Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis (2008) (655)
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. (2010) (632)
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire (1994) (607)
Two levels of protection for the B cell genome during somatic hypermutation (2008) (589)
Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death (1993) (561)
Induction of self-tolerance in mature peripheral B lymphocytes (1989) (549)
DNA repair is limiting for haematopoietic stem cells during ageing (2007) (520)
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells (1995) (517)
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. (1996) (492)
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. (1998) (458)
Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor (1996) (441)
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. (2006) (433)
Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. (1995) (424)
Control systems and decision making for antibody production (2010) (421)
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. (1997) (419)
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA (2007) (408)
A critical role for complement in maintenance of self-tolerance. (1998) (405)
Antigen-induced B-cell death and elimination during germinal-centre immune responses (1995) (404)
Transgenic mice and analysis of B-cell tolerance. (1992) (382)
Multistep Pathogenesis of Autoimmune Disease (2007) (381)
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells (1994) (365)
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells (1994) (353)
Self-tolerance checkpoints in B lymphocyte development. (1995) (347)
Positive versus negative signaling by lymphocyte antigen receptors. (1998) (345)
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. (1994) (330)
Gene Dosage–limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity (2004) (315)
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. (2003) (312)
T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow (2009) (310)
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. (2009) (308)
Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. (1995) (300)
Dependence of germinal center B cells on expression of CD21/CD35 for survival. (1998) (299)
T cells and follicular dendritic cells in germinal center B‐cell formation and selection (2010) (282)
Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 (1996) (278)
Breakdown of self-tolerance in anergic B lymphocytes (1991) (277)
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers (2015) (275)
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (2009) (263)
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage (2016) (249)
Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. (1991) (216)
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. (1996) (215)
Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory (2002) (213)
The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA (2014) (211)
A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. (1997) (210)
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation (2015) (203)
Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling (2003) (202)
Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords (1995) (201)
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. (2011) (199)
B‐lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays (2000) (198)
CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes (1997) (197)
NINJ1 mediates plasma membrane rupture during lytic cell death (2020) (194)
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity (2014) (193)
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation (2011) (188)
Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. (1997) (187)
How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis (2000) (186)
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. (2004) (180)
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration (2009) (179)
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice (2011) (178)
Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. (1994) (174)
Comparison of predicted and actual consequences of missense mutations (2015) (173)
Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes (2002) (165)
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. (2003) (163)
A Role for Alström Syndrome Protein, Alms1, in Kidney Ciliogenesis and Cellular Quiescence (2006) (159)
Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen (1992) (158)
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. (2007) (154)
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes (2018) (154)
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB (2013) (152)
The need for central and peripheral tolerance in the B cell repertoire. (1990) (147)
Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. (2006) (145)
Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS. (2009) (145)
Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice. (1992) (143)
Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4. (1997) (138)
Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. (1998) (137)
Enhancement and suppression of signaling by the conserved tail of IgG memory–type B cell antigen receptors (2007) (137)
Functional Annotation of Mouse Genome Sequences (2001) (136)
The actin regulator coronin-1A is mutated in a thymic egress deficient mouse strain and in a T−B+NK+ SCID patient (2008) (130)
Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. (2013) (128)
Genome-wide ENU mutagenesis to reveal immune regulators. (2001) (126)
Variability and repertoire size of T-cell receptor Vα gene segments (1985) (124)
Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids (2017) (123)
Role of Syk in B-cell development and antigen-receptor signaling. (2000) (121)
Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. (2006) (120)
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes (2016) (113)
Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization (2016) (111)
Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling (2003) (110)
Themis is a member of a new metazoan gene family and is required for completion of thymocyte positive selection (2009) (104)
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes (2011) (104)
Entry of B Cell Receptor into Signaling Domains Is Inhibited in Tolerant B Cells (2000) (103)
Abortive Proliferation of Rare T Cells Induced by Direct or Indirect Antigen Presentation by Rare B Cells In Vivo (1998) (103)
Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice. (1990) (100)
HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse (2015) (98)
Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells (1998) (97)
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination (2018) (97)
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models (2012) (95)
IRF2 transcriptionally induces GSDMD expression for pyroptosis (2019) (92)
Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme. (1991) (91)
Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. (2014) (88)
An Essential Role for Katanin p80 and Microtubule Severing in Male Gamete Production (2012) (88)
The regulation of self-reactive B cells. (1995) (88)
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. (2010) (88)
Pathways for self-tolerance and the treatment of autoimmune diseases (2001) (86)
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. (2016) (85)
A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes. (1994) (84)
Immunological tolerance: Danger – pathogen on the premises! (1996) (84)
ERK Signaling Is a Molecular Switch Integrating Opposing Inputs from B Cell Receptor and T Cell Cytokines to Control TLR4-Driven Plasma Cell Differentiation1 (2006) (84)
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. (2009) (81)
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8− dendritic cells require the intramembrane endopeptidase SPPL2A (2013) (80)
The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs (2010) (79)
Redundant expression but selective utilization of nuclear factor of activated T cells family members. (1997) (78)
Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. (2008) (77)
DOCK8 is critical for the survival and function of NKT cells. (2013) (76)
Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody. (1994) (76)
B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle (2017) (76)
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene (2006) (75)
Self-reactive B Cells Are Not Eliminated or Inactivated by Autoantigen Expressed on Thyroid Epithelial Cells (1997) (73)
Genetic lesions in T‐cell tolerance and thresholds for autoimmunity (2005) (73)
Self Tolerance in the B‐Cell Repertoire (1991) (71)
Secretion of a chimeric T-cell receptor-immunoglobulin protein. (1987) (68)
Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells (2017) (68)
ENU-mutagenesis: insight into immune function and pathology. (2006) (65)
T cell-mediated elimination of B7.2 transgenic B cells. (1997) (64)
RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly (2012) (63)
IgD attenuates the IgM-induced anergy response in transitional and mature B cells (2016) (63)
Expression of T-cell receptor alpha-chain genes in transgenic mice (1988) (60)
Signaling through murine CD38 is impaired in antigen receptor‐unresponsive B cells (1995) (60)
Consequences of the recurrent MYD88L265P somatic mutation for B cell tolerance (2014) (60)
Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor κB2 in Regulating Circulating B Cell Numbers (2002) (60)
Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells (2011) (59)
Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy (2006) (59)
Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies (2013) (59)
Axon growth and guidance genes identify T‐dependent germinal centre B cells (2008) (58)
A mutation in a chromosome condensin II subunit, kleisin β, specifically disrupts T cell development (2007) (57)
Immunology: DNA drives autoimmunity (2002) (57)
Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody (2020) (56)
RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility (2013) (54)
A genomic view of immunology (2001) (53)
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells (2019) (52)
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns. (2019) (52)
A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred (2015) (52)
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. (2011) (51)
LRGUK-1 Is Required for Basal Body and Manchette Function during Spermatogenesis and Male Fertility (2015) (50)
Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation (2015) (49)
Brief Report: Identification of a Pathogenic Variant in TREX1 in Early‐Onset Cerebral Systemic Lupus Erythematosus by Whole‐Exome Sequencing (2014) (49)
Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy. (2011) (48)
Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system. (2005) (46)
Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo. (2002) (46)
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling (2007) (45)
Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations (2013) (45)
Single epitope multiple staining to detect ultralow frequency B cells. (2001) (45)
A mechanism for Ikaros regulation of human globin gene switching (2008) (45)
Gene Dose–Dependent Maturation and Receptor Editing of B Cells Expressing Immunoglobulin (Ig)g1 or Igm/Igg1 Tail Antigen Receptors (2000) (44)
Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes (2014) (43)
Growing up on the streets: why B-cell development differs from T-cell development. (1999) (43)
Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway. (1999) (43)
Lymphocyte homing: The scent of a follicle (1997) (41)
Human lymphoma mutations reveal CARD11 as the switch between self-antigen–induced B cell death or proliferation and autoantibody production (2012) (41)
Spontaneous Follicular Exclusion of SHP1-deficient B Cells Is Conditional on the Presence of Competitor Wild-type B Cells (1998) (41)
B-cell tolerance. (1992) (41)
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency (2010) (40)
Illuminating autoimmune regulators through controlled variation of the mouse genome sequence. (2004) (39)
Bulk Segregation Mapping of Mutations in Closely Related Strains of Mice (2010) (38)
Lymphoma and the control of B cell growth and differentiation. (2006) (38)
Balancing Immunity, Autoimmunity, and Self‐tolerance a (1997) (37)
Clonal silencing of self-reactive B lymphocytes in a transgenic mouse model. (1989) (37)
Danger - pathogen on the premises! Immunological tolerance. (1996) (37)
Reliably Detecting Clinically Important Variants Requires Both Combined Variant Calls and Optimized Filtering Strategies (2015) (36)
ZBTB7B (Th-POK) Regulates the Development of IL-17–Producing CD1d-Restricted Mouse NKT Cells (2012) (36)
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity (2019) (36)
Tracing the action of IL‐2 in tolerance to islet‐specific antigen (2007) (35)
Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes. (1998) (33)
Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion (2016) (33)
Genes, pathways and checkpoints in lymphocyte development and homeostasis (2005) (33)
Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency. (2015) (33)
Candidate gene discovery in autoimmunity by using extreme phenotypes, next generation sequencing and whole exome capture. (2015) (33)
Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome (2015) (32)
CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells (2016) (31)
Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. (2009) (31)
Regulation of mouse CD72 gene expression during B lymphocyte development. (1998) (30)
Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM (2017) (30)
Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy. (2000) (29)
The Role of Endoplasmic Reticulum Stress in Nonimmune Diabetes: NOD.k iHEL, a Novel Model of β Cell Death (2003) (28)
Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability (2021) (28)
Spontaneous B cell hyperactivity in autoimmune-prone MRL mice. (2006) (28)
The Essential Role of DOCK8 in Humoral Immunity (2010) (28)
Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity (2019) (28)
Quantitative Reduction of the TCR Adapter Protein SLP-76 Unbalances Immunity and Immune Regulation (2015) (27)
Discriminating Microbe from Self Suffers a Double Toll (2006) (27)
Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation (2017) (27)
Intrinsic in vitro abnormalities in dendritic cell generation caused by non‐MHC non‐obese diabetic genes (2002) (26)
Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation (2010) (25)
The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ‐specific and systemic autoimmunity (2006) (25)
SnapShot: Interactions between B Cells and T Cells (2015) (24)
Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production (2019) (24)
Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells (2014) (24)
αβ T‐cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors (2018) (24)
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles (2018) (23)
Autoimmunity: The Fas track (1995) (23)
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies (2020) (22)
ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation (2011) (22)
Organ-Specific Autoimmune Disease (2001) (22)
B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects. (2019) (22)
IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up‐regulation CD80/CD86 co‐stimulatory molecules (1995) (21)
F31 Organ-speciﬁc Autoimmune Disease: A Deﬁciency of Tolerogenic (2001) (21)
Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome (2018) (20)
Analysis of Lyn/CD22 double‐deficient B cells in vivo demonstrates Lyn‐ and CD22‐independent pathways affecting BCR regulation and B cell survival (2005) (18)
Cellular mechanisms of self-tolerance. (1989) (18)
Delayed control of herpes simplex virus infection and impaired CD4+ T cell migration to the skin in mouse models of DOCK8 deficiency (2015) (18)
Structural analysis of the myeloma-associated membrane antigen KMA. (1985) (18)
Visualizing the Role of Cbl-b in Control of Islet-Reactive CD4 T Cells and Susceptibility to Type 1 Diabetes (2011) (18)
Analysis of B Cell Memory Formation Using DNA Microarrays (2002) (18)
DeepSNVMiner: a sequence analysis tool to detect emergent, rare mutations in subsets of cell populations (2016) (17)
A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation (2017) (17)
A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development (2016) (17)
A Missense Mutation in the Transcription Factor ETV5 Leads to Sterility, Increased Embryonic and Perinatal Death, Postnatal Growth Restriction, Renal Asymmetry and Polydactyly in the Mouse (2013) (16)
Repression of B 7 . 2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD 4 1 T Cells (1998) (16)
IL-10+CTLA-4+ Th2 Inhibitory Cells Form in a Foxp3-Independent, IL-2–Dependent Manner from Th2 Effectors during Chronic Inflammation (2012) (16)
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment (2014) (16)
A repository of ENU mutant mouse lines and their potential for male fertility research. (2004) (16)
Defective T‐cell function leading to reduced antibody production in a kleisin‐β mutant mouse (2008) (16)
B cell antigen receptor signalling in the balance of tolerance and immunity. (1998) (15)
The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death. (2003) (15)
Understanding the immunological impact of the human mutation explosion. (2013) (15)
Ig heavy chain extracellular spacer confers unique glycosylation of the Mb-1 component of the B cell antigen receptor complex. (1994) (15)
Immune responses: Costimulatory receptors have their say (1998) (14)
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells (2022) (14)
Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion (2017) (14)
DOCK 8 deficiency impairs CD 8 T cell survival and function in humans and mice (2011) (14)
Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif (2019) (13)
Self-tolerance in B lymphocytes. (1989) (13)
Lyn/CD22/SHP-1 and their importance in autoimmunity. (2002) (13)
A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has potential as a therapeutic agent. (1985) (13)
Corrigendum: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection (2010) (13)
Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate (2021) (13)
Novel approaches for identifying genes regulating lymphocyte development and function. (2002) (12)
SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression (2021) (12)
Expression of T cell receptor genes in an antigen-specific hybridoma and radiation-induced variants (1986) (12)
Differential regulation of early and late stages of B lymphocyte development by the μ and δ membrane heavy chains of Ig (1994) (11)
Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo. (2016) (11)
Reducing the search space for causal genetic variants with VASP (2015) (11)
IL-2 prevents deletion of developing T-regulatory cells in the thymus (2017) (11)
Mouse strains with point mutations in TAP1 and TAP2 (2010) (11)
Differential Requirement for the CD45 Splicing Regulator hnRNPLL for Accumulation of NKT and Conventional T Cells (2011) (11)
Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility (2020) (11)
Tuning Antigen Receptor Signaling Review by CD 22 : Integrating Cues from Antigens and the Microenvironment (1997) (11)
Variability and repertoire size of T-cell receptor V alpha gene segments. (1985) (10)
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance (2021) (10)
The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro‐environment (1998) (10)
Glimpses into the balance between immunity and self-tolerance. (2007) (10)
A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy. (2016) (10)
How host defense is encoded in the mammalian genome (2011) (10)
Augmented neutralization of SARS‐CoV‐2 Omicron variant by boost vaccination and monoclonal antibodies (2022) (9)
STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis. (2022) (9)
Tolerance mechanisms in the late phase of the antibody response. (2007) (9)
CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3+ regulatory T cells (2019) (9)
A Novel Mechanism for Complement Activation at the Surface of B Cells Following Antigen Binding1 (2006) (8)
Indirect presentation in the thymus limits naive and regulatory T‐cell differentiation by promoting deletion of self‐reactive thymocytes (2018) (8)
Autoimmunity, self-tolerance and immune homeostasis: from whole animal phenotypes to molecular pathways. (2001) (8)
Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation (2013) (8)
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens (2020) (8)
Understanding Immune Tolerance of Cancer: Re‐Purposing Insights from Fetal Allografts and Microbes (2018) (8)
Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways. (1999) (8)
COVID‐19, varying genetic resistance to viral disease and immune tolerance checkpoints (2020) (8)
T Cell Expansion Is the Limiting Factor of Virus Control in Mice with Attenuated TCR Signaling: Implications for Human Immunodeficiency (2015) (7)
Autoimmune tolerance and Type 1 (insulin-dependent) diabetes mellitus (1992) (7)
Co-expression of an epitope on human free kappa-light chains and on a cytoplasmic component in activated T cells. (1985) (7)
erratum: Differential activation of transcription factors induced by Ca2+ response amplitude and duration (1997) (7)
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA (2008) (6)
Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells (2019) (6)
Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity. (2005) (6)
A repository of ENU mutant mouse lines and their potential for male fertility research (2005) (5)
Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson’s syndrome (2013) (5)
Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse (2015) (5)
T-cell receptor gene structure and function. (1986) (5)
A ZAP‐70 kinase domain variant prevents thymocyte‐positive selection despite signalling CD69 induction (2014) (5)
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation. (2022) (5)
The coming of transgenic mice: tolerance and immune reactivity. (1990) (5)
The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen. (2018) (5)
Foxp 3 regulatory T cells exert asymmetric control over murine helper responses by inducing Th 2 cell apoptosis (2011) (5)
DOCK8-Deficient CD4(+) T Cells are Biased to a Th2 Effector Fate at the Expense of Th1 and Th17 Cells. (2016) (4)
DOCK8 deficiency diminishes thymic T‐regulatory cell development but not thymic deletion (2021) (4)
Uncontrolled CD21 low Age-Associated and B1 B Cell Accumulation Caused by Failure of an EGR2/3 Tolerance Checkpoint (2021) (4)
Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL. (2011) (4)
DOCK 8 de ! ciency impairs CD 8 T cell survival and function in humans and mice (2011) (4)
TLR 4-Driven Plasma Cell Differentiation Receptor and T Cell Cytokines to Control Integrating Opposing Inputs from B Cell ERK Signaling Is a Molecular Switch (2006) (4)
TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints (2016) (4)
Differential regulation of early and late stages of B lymphocyte development by the mu and delta membrane heavy chains of Ig. (1994) (4)
A critical role of complement in regulation of self-reactive B cells (1998) (4)
Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint. (2022) (4)
Immunology: Memory needs no reminders (2000) (3)
Nossal and Pike 1975: A Turning Point in the Effort to Define Self-Tolerance Mechanisms (2007) (3)
Antigen receptor signaling (PP-004) (2010) (3)
Identification of a pathogenic variant in TREX1 in early-onset cerebral SLE by whole-exome sequencing. (2016) (3)
Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (2010) (3)
Finding new immune regulatory genes by ENU mutagenesis (2012) (3)
Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation (2016) (3)
The essential role of DOCK 8 in humoral immunity (2014) (3)
Murine T-cell receptor genes. (1987) (3)
Self-Tolerance in B-Cells from Different Lines of Lysozyme Double-Transgenic Mice (1989) (3)
Decreased TCR signaling through Card11 differentially compromises Foxp3+ regulatory versus Th2 effector cells to cause allergy (2011) (3)
Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice (2021) (2)
SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells (2022) (2)
Balancing immunity andtolerance: Deleting andtuning lymphocyte repertoires (1996) (2)
Human transitional and IgMlow mature naïve B cells preserve permissive B‐cell receptors (2021) (2)
Quantitative reduction of the T cell receptor adapter protein SLP-76 unbalances immunity and immune regulation (2015) (2)
erratum: How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis (2000) (2)
Loss of hnRNPLL‐dependent splicing of Ptprc has no impact on B‐cell development, activation and terminal differentiation into antibody‐secreting cells (2020) (2)
Sequencing and Affinity Determination of Antigen-Specific B Lymphocytes from Peripheral Blood. (2018) (1)
Oligoclonal lymphocytosis and cytokine derangement in a case of severe adverse drug reaction (2019) (1)
Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint (2021) (1)
Manipulation of Transgene-Encoded Self-Antigens to Explore Mechanisms of B Cell Tolerance (1994) (1)
Genetic and structural basis of the human anti-α-galactosyl antibody response (2022) (1)
A novel mutation in the nucleoporin NUP35 causes murine degenerative colonic smooth muscle myopathy (2016) (1)
Genetics of Disease Progression in Diffuse Large B-Cell Lymphoma: Clonal Selection and Acquisition of Newly Acquired Somatic Mutations at Relapse (2014) (1)
Signals regulating B lymphocyte migration and survival in lymphoid tissues (1996) (1)
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles (2018) (1)
A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice (2021) (1)
Intermediate genetic lesions in TCR signal transduction induce spontaneous autoimmunity and immune deysregulation (2005) (0)
27th HUGO-IABCR congress 2010: poster abstracts 5–7 October 2010, Singapore (2010) (0)
Regulatory T cells (PP-045) (2010) (0)
The 6th Japan and US Collaboration Conference in Gastroenterology Program (2012) (0)
Finding new immune regulatory genes by ENU mutagenesis (2012) (0)
Epigenetic changes during tumour development – Functional epigenetics study (2020) (0)
Tolerance and transplantation (SY2-4) Chairpersons: Mitsuru Matsumoto, Kathryn Wood (2010) (0)
epithelial cells Developmental kinetics, turnover and stimulatory capacity of thymic (2010) (0)
Environmental and genetic disease modifiers of haploinsufficiency of A20 (2022) (0)
Modulating Immune Responses (2019) (0)
Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases (2022) (0)
Single cell multi-modal analysis with VDJPuzzle identifies clonality and gene expression profiles of T and B cells (2019) (0)
Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants (2019) (0)
MUTATIONS IN THE INTRAMEMBRANE ENDOPEPTIDASE SPPL2A AFFECT HUMORAL IMMUNITY AND B-CELL SURVIVAL BY REDUCING SURFACE BCR AND BAFF-R EXPRESSION AND AFFECTING CD74 METABOLISM (2012) (0)
EGR2 and EGR3 function in a cell-intrinsic and partially redundant manner to suppress the accumulation of B1a cells and CD21low CD23low age-associated B cells (2021) (0)
Erratum: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection (Nature Immunology (2009) 10 (831-839)) (2010) (0)
An allelic series of CD45 dosages uncouples basal and inducible TCR signaling during thymic development (84.13) (2009) (0)
L-Like Mutation Heterogeneous Nuclear Ribonucleoprotein Cell Deficiency Resulting from TIsoforms for TCR Signaling and Peripheral Consequences of Increased CD 45 RA and RC (2010) (0)
A role for the Alström syndrome protein, Alms1, in ciliogenesis and regulation of cellular quiescence in kidney proximal tubules (2005) (0)
University of Dundee The Ubiquitin Ligase Adaptor NDFIP 1 Selectively Enforces a CD 8 + T Cell Tolerance Checkpoint to High-Dose Antigen (2018) (0)
Two Waves of T Cell Negative Selection in the Thymus: Why? (2014) (0)
Isoforms for TCR Signaling and Peripheral Consequences of Increased CD45RA and RC (2010) (0)
A dominant-negative mutation in TNFR1 results in increased susceptibility to pulmonary tuberculosis infection (2016) (0)
Endoplasmic reticulum stress in goblet cells leads directly to intestinal inflammation with similarities to ulcerative colitis (2007) (0)
Altered gene expression in Henmt1 PIN/PIN spermatocytes and round spermatids. (2015) (0)
The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA (2014) (0)
R7: CLINICAL IMPACT OF WHOLE GENOME SEQUENCING ON THE DIAGNOSIS AND MANAGEMENT OF PATIENTS WITH PRIMARY IMMUNODEFICIENCY DISEASES - THE CLINICAL IMMUNOGENOMICS RESEARCH CONSORTIUM AUSTRALIA (CIRCA) EXPERIENCE (2018) (0)
Chair's Introduction (2007) (0)
Identification of Novel Regulators of B Cell Development and Function Using ENU Mutagenesis (2014) (0)
Asymmetric immune regulation by regulatory T cells (2011) (0)
Differential activationof transcription factors inducedbyCa 2 þ response amplitudeandduration (0)
Ikaros drives human haemoglobin switching by facilitating active chromatin hub formation (2007) (0)
R4: CHARACTERISATION OF CHANGE IN REACTION ELICITING DOSE IN A DOUBLE-BLIND, RANDOMISED CONTROLLED TRIAL EVALUATING PROBIOTIC-PEANUT ORAL IMMUNOTHERAPY FOR TREATMENT OF PEANUT ALLERGY (2018) (0)
Overactive STAT3 drives accumulation of disease-associated CD21low B cells (2021) (0)
The transcriptional factor, IKAROS, plays a key role in γ–β globin gene switching (2007) (0)
Abstract LB-121: Exploring the germ-line contribution to exceptional response to PD-1/PD-L1 inhibition in patients with metastatic non-small-cell lung cancer by whole genome sequencing (2018) (0)
Tolerance in lysozyme transgenic mice (1989) (0)
Decision letter: Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies' (2019) (0)
Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers (2022) (0)
Genetic control of T cell activation  Implication for autoimmunity and cancer  Lofoten, Norway, August 18th‐22th 2005 (2005) (0)
Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells (2019) (0)
Thymic precursors to the mucosal-associated invariant T cell lineage (2016) (0)
DOCK 8-Deficient CD 4 + T Cells are Biased to a Th 2 Effector Fate at the Expense of Th 1 and Th 17 Cells (2016) (0)
241 Single cell genomics of self-reactive B cells reveals the evolution from benign to pathogenic autoantibody and strategies for early diagnosis and personalised treatment (2019) (0)
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells (2022) (0)
Author response: Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment (2014) (0)
Tolerant Autoreactive B Lymphocytes in the Follicular Mantle Zone Compartment: Substrates for Receptor Editing and Reform (1993) (0)
7 th European Workshop on Immune-Mediated Inflammatory Diseases Noordwijk (2012) (0)
Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice (2020) (0)
The Ubiquitin Ligase Adap tor NDFIP 1 Selectively Enforces a CD 8 + T Cell Tolerance Checkpoint to High-Dose Antigen Graphical (2018) (0)
Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis (2007) (0)
IDENTIFYING GENETIC MODIFIERS OF BREAST CANCER RISK IN BRCA1 AND BRCA2 MUTATION CARRIERS IN THE CONSORTIUM OF INVESTIGATORS OF MODIFIERS OF BRCA1 AND BRCA2 (CIMBA) (2007) (0)
Cancer immunotherapy: new leads on an elusive goal (1998) (0)
Linking Causal Relationships between Genes and Phenotypes of the Immune System Through Large Scale ENU Mutagenesis of the Mammalian Genome (2014) (0)
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes (2019) (0)
ImmunodeficiencySignaling: Implications for Human Virus Control in Mice with Attenuated TCR T Cell Expansion Is the Limiting Factor of (2015) (0)
Immunodeficiency and Abnormal B Cell Synapse Formation due to DOCK8 Mutations in Mice (2010) (0)
Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome (2015) (0)
The OTU Domain of A20 Silences the Tissue Microenvironment for Immunological Non-Responsiveness.: Abstract# C3064 (2014) (0)
IL-10 production by Th2 cells in vivo occurs by sub-differentiation into a novel, suppressive IL-10+CTLA-4hi Th2 subset (152.28) (2011) (0)
The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells (2020) (0)
OLD GENES, NEW LIFESTYLES, AND FUTURE MEDICINE (1998) (0)
Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases (2021) (0)
Unlocking the mammalian "phenome double right arrow genome" code with the support of the Australian Phenomics Facility (2005) (0)
Erratum: Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22- independent pathways affecting BCR regulation and B cell survival (European Journal of Immunology (2005) vol. 35 (12) (3714) 10.1002/eji.200535247) (2005) (0)
Manner from Th 2 Effectors during Chronic Dependent − in a Foxp 3-Independent , IL-2 Th 2 Inhibitory Cells Form + CTLA-4 + IL-10 (2012) (0)
Specific activation of human beta-Globin gene expression by the transcription factor Ikaros (2005) (0)
166 T Cell Deficiency Resulting form Aberrant Pre-mRNA Alternative Splicing (2007) (0)
Safe havens for self-reactive cells (1992) (0)
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells (2023) (0)
Germinal center reaction (WS-031) Chairpersons: Nobuo Sakaguchi, Garnett Kelsoe (2010) (0)
P1.04-11 Exploring the Germ-Line Contribution to Exceptional Response to PD-1/PD-L1 Inhibition in Patients with NSCLC by Whole Genome Sequencing (2018) (0)
Decision letter: Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies' (2019) (0)
Murine T-Cell Receptor Genes and the Problems of Cellular Recognition and Repertoire Selection (1986) (0)
Paradigm regained: similarities and differences between T cell receptor and immunoglobulin genes. (1986) (0)
8. The identification of mutations affecting male fertility using denaturing high performance liquid chromatography (2003) (0)
to Type 1 Diabetes Islet-Reactive CD4 T Cells and Susceptibility Visualizing the Role of Cbl-b in Control of (2011) (0)
R2: A MOUSE MODEL FOR HUMAN CVID CAUSED BY A POINT MUTATION IN IKAROS (2018) (0)
1 Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells. (2006) (0)

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