Chris Holmes
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British mathematician
Chris Holmes 's AcademicInfluence.com Rankings
Chris Holmes mathematics Degrees
Mathematics
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Measure Theory
#4246
World Rank
#5002
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Mathematics
Chris Holmes 's Degrees
- Masters Mathematics University of Oxford
Why Is Chris Holmes Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christopher C. Holmes is a British statistician. He has held the position of Professor of Biostatistics in Genomics in the Nuffield Department of Clinical Medicine and the Department of Statistics at the University of Oxford since September 2014, a post that carries with it a Fellowship of St Anne's College, Oxford. Previously he was titular Professor of Biostatistics and a Fellow of Lincoln College. After working in industry he completed his doctorate in Bayesian statistics at Imperial College, London, supervised by Adrian Smith.
Chris Holmes 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls (2010) (600)
- Key Issues in Conducting a Meta-Analysis of Gene Expression Microarray Datasets (2008) (473)
- Genome-wide association study of copy number variation in 16,000 cases of eight common diseases and 3,000 shared controls (2010) (465)
- Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study (2020) (367)
- Factors influencing success of clinical genome sequencing across a broad spectrum of disorders (2015) (319)
- Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments (2013) (230)
- A Quantitative Study of Gene Regulation Involved in the Immune Response of Anopheline Mosquitoes (2006) (228)
- Genetic evidence of assortative mating in humans (2017) (199)
- Machine learning and artificial intelligence research for patient benefit: 20 critical questions on transparency, replicability, ethics, and effectiveness (2020) (192)
- GWAS identifies 14 loci for device-measured physical activity and sleep duration (2018) (190)
- Human metabolic profiles are stably controlled by genetic and environmental variation (2011) (151)
- Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells (2013) (146)
- Mapping in Structured Populations by Resample Model Averaging (2009) (145)
- The epidemiological impact of the NHS COVID-19 app (2021) (143)
- Analysis of mammalian gene function through broad based phenotypic screens across a consortium of mouse clinics (2015) (135)
- Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications (2014) (133)
- A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection (2011) (129)
- Statistical machine learning of sleep and physical activity phenotypes from sensor data in 96,220 UK Biobank participants (2018) (119)
- Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden (2014) (95)
- Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture (2009) (90)
- Bayesian coclustering of Anopheles gene expression time series: study of immune defense response to multiple experimental challenges. (2005) (69)
- Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes (2012) (67)
- Epidemiological changes on the Isle of Wight after the launch of the NHS Test and Trace programme: a preliminary analysis (2020) (63)
- Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data (2019) (61)
- Transcriptome Deconvolution of Heterogeneous Tumor Samples with Immune Infiltration (2017) (61)
- High-throughput mouse phenomics for characterizing mammalian gene function (2018) (61)
- MicroRNA Expression in Abdominal and Gluteal Adipose Tissue Is Associated with mRNA Expression Levels and Partly Genetically Driven (2011) (58)
- Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. (2008) (57)
- Erythrocytosis associated with a novel missense mutation in the BPGM gene (2010) (37)
- Principles of Experimental Design for Big Data Analysis. (2017) (35)
- The impact of age on genetic risk for common diseases (2020) (30)
- Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda (2016) (28)
- Hodgkin–Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods (2015) (28)
- Reprioritizing Genetic Associations in Hit Regions Using LASSO-Based Resample Model Averaging (2012) (28)
- Therapeutic Implications of GIPC1 Silencing in Cancer (2010) (28)
- Elusive Copy Number Variation in the Mouse Genome (2010) (27)
- Machine learning improves mortality risk prediction after cardiac surgery: Systematic review and meta-analysis. (2020) (27)
- Beyond Toplines : Heterogeneous Treatment Effects in Randomized Experiments ∗ (2009) (27)
- Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections (2014) (27)
- The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq (2017) (23)
- Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model (2011) (21)
- Machine learning and AI research for Patient Benefit: 20 Critical Questions on Transparency, Replicability, Ethics and Effectiveness (2018) (20)
- Integrative network-based Bayesian analysis of diverse genomics data (2013) (18)
- Bayesian hierarchical mixture modeling to assign copy number from a targeted CNV array (2011) (17)
- Time varying association between deprivation, ethnicity and SARS-CoV-2 infections in England: A population-based ecological study (2022) (14)
- Inferring proximity from Bluetooth Low Energy RSSI with Unscented Kalman Smoothers (2020) (14)
- Improving local prevalence estimates of SARS-CoV-2 infections using a causal debiasing framework (2021) (13)
- Machine learning analysis plans for randomised controlled trials: detecting treatment effect heterogeneity with strict control of type I error (2020) (12)
- Risk scoring calculation for the current NHSx contact tracing app (2020) (12)
- Comparing two sequential Monte Carlo samplers for exact and approximate Bayesian inference on biological models (2017) (10)
- COVID-19 incidence and R decreased on the Isle of Wight after the launch of the Test, Trace, Isolate programme (2020) (10)
- Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision. (2021) (9)
- Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision (2021) (9)
- Interoperability of statistical models in pandemic preparedness: principles and reality. (2021) (9)
- Robust Linear Models for Cis-eQTL Analysis (2015) (8)
- GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease (2018) (8)
- nEASE: a method for gene ontology subclassification of high-throughput gene expression data (2012) (7)
- A note on statistical repeatability and study design for high‐throughput assays (2016) (6)
- On testing for genetic association in case‐control studies when population allele frequencies are known (2009) (6)
- Application of a Novel Score Test for Genetic Association Incorporating Gene-Gene Interaction Suggests Functionality for Prostate Cancer Susceptibility Regions (2011) (6)
- A Novel Test for Gene-Ancestry Interactions in Genome-Wide Association Data (2012) (6)
- Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis (2021) (6)
- Protocol for the development of the Wales Multimorbidity e-Cohort (WMC): data sources and methods to construct a population-based research platform to investigate multimorbidity (2021) (6)
- Development and assessment of a machine learning tool for predicting emergency admission in Scotland (2021) (5)
- NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer. (2019) (5)
- High trait variability in optimal polygenic prediction strategy within multiple-ancestry cohorts (2021) (5)
- Bayesian imputation of COVID‐19 positive test counts for nowcasting under reporting lag (2021) (5)
- Local prevalence of transmissible SARS-CoV-2 infection : an integrative causal model for debiasing fine-scale targeted testing data (2021) (5)
- A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices (2020) (4)
- Harnessing the Potential of Digital Technologies for the Early Detection of Neurodegenerative Diseases (EDoN) (2019) (4)
- A metagene of NRF2 expression is a prognostic biomarker in all stage colorectal cancer (2019) (3)
- Graphing and reporting heterogeneous treatment effects through reference classes (2019) (3)
- Audio-based AI classifiers show no evidence of improved COVID-19 screening over simple symptoms checkers (2022) (3)
- A large-scale and PCR-referenced vocal audio dataset for COVID-19 (2022) (3)
- All systems GO for understanding mouse gene function (2004) (3)
- Machine learning for randomised controlled trials: identifying treatment effectheterogeneity with strict control of type I error (2018) (2)
- Therapeutic Implications of GIPC 1 Silencing in Cancer (2010) (2)
- Statistical Design and Analysis for Robust Machine Learning: A Case Study from COVID-19 (2022) (2)
- Reply to Wirth et al.: In vivo profiles show continuous variation between 2 cellular populations (2009) (2)
- A spatio-temporal framework for modelling wastewater concentration during the COVID-19 pandemic (2022) (1)
- Rejoinder: Approximate Models and Robust Decisions (2016) (1)
- A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples (2022) (1)
- Age modulates genetic risk for multiple common diseases (2020) (1)
- Functional classi fi cation analysis of somatically mutated genes in human breast and colorectal cancers (2008) (1)
- Modelling the impact of rapid tests, tracing and distancing in lower-income countries suggest optimal policies varies with rural-urban settings (2021) (1)
- Big data and design of experiments (2016) (1)
- Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections (2014) (1)
- Integrative network-based Bayesian analysis of diverse genomics data (2013) (1)
- Optimal strategies for learning multi-ancestry polygenic scores vary across traits (2022) (1)
- Statistical inference with exchangeability and martingales (2023) (1)
- Detecting interacting genetic loci with effects on quantitative traits where the nature and order of the interaction are unknown (2010) (1)
- A Bayesian Co-clustering of Anopheles Gene Expression Time Series Responses to Multiple Immune Challenges (2005) (1)
- Running head: Mapping in structured populations (2009) (0)
- The genetic architecture of changes in adiposity during adulthood (2023) (0)
- BIOINFORMATICS nEASE: a method for gene ontology subclassification of high-throughput gene expression data (2012) (0)
- The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq (2017) (0)
- Determinants of nucleosome organisation and transcription regulation by histone marks (2012) (0)
- GWAS identifies 14 loci for device-measured physical activity and sleep duration (2018) (0)
- Multivariate phenotype analysis enables genome-wide inference of mammalian gene function (2022) (0)
- Micro-ribonucleic acid expression profiling and expression quantitative trait loci analysis in human gluteal and abdominal adipose tissue (2010) (0)
- Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data (2019) (0)
- Prioritising future areas of research into the promotion of physical activity (2016) (0)
- Differential microRNA expression in abdominal and gluteal adipose tissue is partly genetically driven (2010) (0)
- Robust Statistical Methods For Genome-Wide Eqtl Analysis (2012) (0)
- Age-dependent topic modelling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk (2022) (0)
- Improving local prevalence estimates of SARS-CoV-2 infections using a causal debiasing framework (2021) (0)
- Assessments and developments in constructing a National Health Index for policy making, in the United Kingdom (2022) (0)
- Time varying association between deprivation, ethnicity and SARS-CoV-2 infections in England: a space-time study (2021) (0)
- Advances in Statistical Bioinformatics: Bayesian Graphical Models for Integrating Multiplatform Genomics Data (2013) (0)
- Multilocus approaches to the detection of disease susceptibility regions: methods and applications (2012) (0)
- A Principled Experimental Design Approach to Big Data Analysis (2017) (0)
- Extensions of the case-control design in genome-wide association studies (2012) (0)
- Abstract 2747: Application of a novel multi-locus test for genetic association incorporating gene-gene interaction suggests functionality for multiple susceptibility loci for prostate cancer (2011) (0)
- Increasing statistical power and generalizability in genomics microarray research (2009) (0)
- A Bayesian chromosome painting approach to detect signals of incomplete positive selection in sequence data : applications to 1000 genomes (2014) (0)
- Correction to: Graphing and reporting heterogeneous treatment effects through reference classes (2020) (0)
- Author response: Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision (2021) (0)
- Causal predictive inference and target trial emulation (2022) (0)
- A Bayesian model for estimating with-in host P. falciparum haplotype frequencies (2012) (0)
- Causal Falsification of Digital Twins (2023) (0)
- Generating the Right Evidence at the Right Time: Principles of a New Class of Flexible Augmented Clinical Trial Designs (2022) (0)
- Running title : Mapping in structured populations by resample model averaging Running head : Mapping in structured populations (2009) (0)
- Statistical methods for mapping complex traits (2014) (0)
- Genetic effects in replicated miRNA eQTLs in abdominal adipose tissue (see Materials and Methods section for criteria). (2011) (0)
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