Chris Ponting

Q: What Schools Are Affiliated With Chris Ponting

Chris Ponting is affiliated with the following schools: University of Oxford, University of Edinburgh, Pompeu Fabra University, University of Cambridge

Chris Ponting's AcademicInfluence.com Rankings

Chris Ponting

Biology

#2989

World Rank

#4642

Historical Rank

Genetics

#258

World Rank

#308

Historical Rank

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Biology

Why Is Chris Ponting Influential?

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According to Wikipedia, Christopher Paul Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Chair of Medical Bioinformatics at the University of Edinburgh and group leader in the MRC Human Genetics Unit. He is also an Associate Faculty member of the Wellcome Trust Sanger Institute, a Fellow of the Academy of Medical Sciences, member of the European Molecular Biology Organisation and Fellow of the Royal Society of Edinburgh. His research focuses on long noncoding RNA function and evolution, on single cell biology and on disease genomics. Outside of science, Chris is an amateur novelist and wrote an unpublished, science fiction novel about engineered viruses.

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Chris Ponting's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Initial sequencing and analysis of the human genome. (2001) (15222)
Initial sequencing and comparative analysis of the mouse genome. (2002) (4609)
Evolution and Functions of Long Noncoding RNAs (2009) (4485)
SMART, a simple modular architecture research tool: identification of signaling domains. (1998) (3541)
Regulation of chromatin structure by site-specific histone H3 methyltransferases (2000) (2820)
Genome sequence, comparative analysis and haplotype structure of the domestic dog (2005) (2448)
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution (2004) (2417)
Genome sequence of the Brown Norway rat yields insights into mammalian evolution (2004) (2053)
Evolution of genes and genomes on the Drosophila phylogeny (2007) (1992)
Functional impact of global rare copy number variation in autism spectrum disorders (2010) (1891)
Mouse genomic variation and its effect on phenotypes and gene regulation (2011) (1398)
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase (2007) (1375)
The Human Cell Atlas (2017) (1285)
SMART: a web-based tool for the study of genetically mobile domains (2000) (1232)
Sequencing depth and coverage: key considerations in genomic analyses (2014) (1082)
SMART 4.0: towards genomic data integration (2004) (1016)
Genetic mechanisms of critical illness in COVID-19 (2020) (887)
The genome of a songbird (2010) (834)
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. (2010) (819)
The genomic substrate for adaptive radiation in African cichlid fish (2014) (811)
The InterPro Database, 2003 brings increased coverage and new features (2003) (742)
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences (2007) (715)
Genome analysis of the platypus reveals unique signatures of evolution (2008) (711)
Recent improvements to the SMART domain-based sequence annotation resource (2002) (693)
Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System (2013) (683)
Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. (2007) (682)
Insights into hominid evolution from the gorilla genome sequence (2012) (670)
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection (2006) (622)
The GAF domain: an evolutionary link between diverse phototransducing proteins. (1997) (594)
Protein repeats: structures, functions, and evolution. (2001) (583)
Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan. (2001) (576)
G&T-seq: parallel sequencing of single-cell genomes and transcriptomes (2015) (576)
The genome of the green anole lizard and a comparative analysis with birds and mammals (2011) (573)
InterPro, progress and status in 2005 (2004) (573)
Finishing the euchromatic sequence of the human genome (2004) (571)
The African coelacanth genome provides insights into tetrapod evolution (2013) (563)
Systematic identification of novel protein domain families associated with nuclear functions. (2002) (551)
Comparative and demographic analysis of orang-utan genomes (2011) (545)
Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity (2015) (531)
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. (2003) (502)
Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse (2009) (472)
Mapping the human genetic architecture of COVID-19 (2021) (455)
The bonobo genome compared with the chimpanzee and human genomes (2012) (455)
The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA (2014) (444)
EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer (2003) (441)
PDZ Domains: Targeting signalling molecules to sub‐membranous sites (1997) (437)
The Reality of Pervasive Transcription (2011) (418)
The cytoplasmic helical linker domain of receptor histidine kinase and methyl-accepting proteins is common to many prokaryotic signalling proteins. (1999) (418)
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands (2012) (411)
START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins. (1999) (406)
InterPro: An Integrated Documentation Resource for Protein Families, Domains and Functional Sites (2002) (376)
PAS: a multifunctional domain family comes to light (1997) (370)
Genomic and Transcriptional Co-Localization of Protein-Coding and Long Non-Coding RNA Pairs in the Developing Brain (2009) (366)
Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations (2015) (365)
Transcriptional regulatory functions of nuclear long noncoding RNAs (2014) (361)
The helix-hairpin-helix DNA-binding motif: a structural basis for non- sequence-specific recognition of DNA (1996) (355)
Single-Cell Multiomics: Multiple Measurements from Single Cells (2017) (352)
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. (2009) (349)
Positional cloning of a novel gene influencing asthma from Chromosome 2q14 (2003) (342)
Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. (1999) (332)
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma (2003) (325)
SMART: identification and annotation of domains from signalling and extracellular protein sequences (1999) (320)
Identification of region-specific astrocyte subtypes at single cell resolution (2020) (317)
Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains? (1996) (314)
SAM as a protein interaction domain involved in developmental regulation (1997) (313)
IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices (1999) (313)
Considerations when investigating lncRNA function in vivo (2014) (307)
A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues (1996) (306)
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage (2013) (305)
Rapid Turnover of Long Noncoding RNAs and the Evolution of Gene Expression (2012) (303)
The natural history of protein domains. (2002) (299)
On the evolution of protein folds: are similar motifs in different protein folds the result of convergence, insertion, or relics of an ancient peptide world? (2001) (288)
The Protein Composition of Mitotic Chromosomes Determined Using Multiclassifier Combinatorial Proteomics (2010) (285)
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. (2004) (279)
Bias of Selection on Human Copy-Number Variants (2006) (271)
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia (2014) (269)
Transcribed dark matter: meaning or myth? (2010) (268)
A Transcriptomic Atlas of Mouse Neocortical Layers (2011) (264)
Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan Taxa (2009) (255)
Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness (2009) (252)
Evidence for PDZ domains in bacteria, yeast, and plants (1997) (247)
Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes (2010) (246)
Natural genetic variation caused by small insertions and deletions in the human genome. (2011) (244)
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. (2008) (240)
JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. (2001) (233)
Plasminogen: a structural review. (1992) (225)
8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage (2014) (222)
Tudor domains in proteins that interact with RNA. (1997) (215)
CHROMA: consensus-based colouring of multiple alignments for publication (2001) (214)
Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity (2010) (209)
Comparison of the genomes of human and mouse lays the foundation of genome zoology. (2003) (202)
ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. (1996) (202)
Homology-based method for identification of protein repeats using statistical significance estimates. (2000) (201)
SPRY domains in ryanodine receptors (Ca(2+)-release channels). (1997) (199)
Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System (2014) (198)
Identification and Properties of 1,119 Candidate LincRNA Loci in the Drosophila melanogaster Genome (2012) (198)
A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration. (2001) (191)
The long non-coding RNA Paupar regulates the expression of both local and distal genes (2014) (187)
GAT: a simulation framework for testing the association of genomic intervals (2013) (187)
A novel family ofras-binding domains (1996) (186)
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates (2013) (185)
Concepts and principles of glycobiology (1993) (184)
Elevated rates of protein secretion, evolution, and disease among tissue-specific genes. (2003) (183)
Genome-Wide Identification of Human Functional DNA Using a Neutral Indel Model (2005) (182)
Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit (2011) (180)
DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. (1995) (176)
RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts (2015) (174)
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa (2008) (174)
TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains? (2002) (173)
Identification of a novel family of presenilin homologues. (2002) (171)
Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis (2019) (171)
High Incidence of Unrecognized Visceral/Neurological Late-onset Niemann-Pick Disease, type C1 Predicted by Analysis of Massively Parallel Sequencing Data Sets (2015) (170)
SMART, a simple modular architecture research tool (1998) (166)
The genomic landscape shaped by selection on transposable elements across 18 mouse strains (2012) (163)
Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism? (1997) (162)
Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAs (2013) (160)
Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery (2014) (160)
SAM: A novel motif in yeast sterile and drosophila polyhomeotic proteins (1995) (157)
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing (2014) (157)
High levels of RNA-editing site conservation amongst 15 laboratory mouse strains (2012) (157)
Phylogenetic Reconstruction of Orthology, Paralogy, and Conserved Synteny for Dog and Human (2006) (155)
Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk (2018) (154)
A latrophilin/CL-1-like GPS domain in polycystin-1 (1999) (153)
PIN domains in nonsense-mediated mRNA decay and RNAi (2000) (152)
Vitamin K epoxide reductase: homology, active site and catalytic mechanism. (2004) (150)
What fraction of the human genome is functional? (2011) (150)
Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes. (2007) (146)
The long non-coding RNA Dali is an epigenetic regulator of neural differentiation (2014) (146)
Pleckstrin's repeat performance: a novel domain in G-protein signaling? (1996) (146)
Common Ancestry of the CENP-A Chaperones Scm3 and HJURP (2009) (143)
Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans (2011) (143)
The crystal structure of the catalytic domain of human urokinase-type plasminogen activator. (1995) (138)
Syncoilin, a Novel Member of the Intermediate Filament Superfamily That Interacts with α-Dystrobrevin in Skeletal Muscle* (2001) (137)
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells (2016) (135)
Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. (2000) (134)
Defensins and the convergent evolution of platypus and reptile venom genes. (2008) (132)
Structural and mechanistic insights into ras association domains of phospholipase C epsilon. (2006) (132)
Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes (2004) (131)
Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes (2003) (131)
Homologues of 26S proteasome subunits are regulators of transcription and translation (1998) (130)
Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain (2000) (129)
Diagnostically relevant facial gestalt information from ordinary photos (2014) (127)
Swaposins: circular permutations within genes encoding saposin homologues. (1995) (127)
Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomes. (2004) (126)
UIF, a New mRNA Export Adaptor that Works Together with REF/ALY, Requires FACT for Recruitment to mRNA (2009) (124)
Novel domains and orthologues of eukaryotic transcription elongation factors. (2002) (124)
Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins. (2000) (123)
Molecular evolution of genes in avian genomes (2010) (123)
Sexual selection and the adaptive evolution of mammalian ejaculate proteins. (2007) (121)
A novel domain suggests a ciliary function for ASPM, a brain size determining gene (2006) (121)
Whole-genome sequencing reveals host factors underlying critical COVID-19 (2022) (120)
Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy (2014) (120)
The functional repertoires of metazoan genomes (2008) (118)
Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. (2012) (118)
Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T–seq (2016) (117)
Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9 (2013) (115)
Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. (2001) (113)
Predicting protein cellular localization using a domain projection method. (2002) (113)
Predicting long non-coding RNAs using RNA sequencing. (2013) (106)
Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921)) (2001) (106)
Long noncoding RNAs in B-cell development and activation. (2016) (100)
Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. (2000) (98)
Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex (2000) (98)
A novel family of Ras-binding domains. (1996) (97)
Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells (2015) (96)
Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases. (2000) (95)
Reduced purifying selection prevails over positive selection in human copy number variant evolution. (2008) (94)
Phospholipase Czeta, the trigger of egg activation in mammals, is present in a non-mammalian species. (2005) (93)
Conformational studies of human plasminogen and plasminogen fragments: evidence for a novel third conformation of plasminogen. (1994) (92)
Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling (1999) (92)
Analysis of the African coelacanth genome sheds light on tetrapod evolution (2013) (92)
Evolution of domain families. (2000) (92)
The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein. (2001) (91)
Intergenic lncRNAs and the evolution of gene expression. (2014) (91)
Identification of the MMS22L-TONSL complex that promotes homologous recombination. (2010) (90)
Massive turnover of functional sequence in human and other mammalian genomes. (2010) (90)
Evolution of primary microcephaly genes and the enlargement of primate brains. (2005) (90)
Evidence that peroxiredoxins are novel members of the thioredoxin fold superfamily (1998) (89)
Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis. (2016) (89)
Sialidase‐like Asp‐boxes: Sequence‐similar structures within different protein folds (2001) (87)
The breast cancer gene product TSG101: a regulator of ubiquitination? (1997) (86)
What are the genomic drivers of the rapid evolution of PRDM9? (2011) (86)
Chlamydial homologues of the MACPF (MAC/perforin) domain (1999) (86)
Evolution and comparative genomics of odorant- and pheromone-associated genes in rodents. (2004) (85)
Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex. (1998) (84)
Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations. (2014) (83)
Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. (2007) (81)
Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. (2003) (81)
Homology explains the functional similarities of Treslin/Ticrr and Sld3 (2010) (79)
Adult pallium transcriptomes surprise in not reflecting predicted homologies across diverse chicken and mouse pallial sectors (2013) (79)
Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus (2011) (78)
Unexpected selection to retain high GC content and splicing enhancers within exons of multiexonic lncRNA loci (2015) (78)
Understanding functional miRNA–target interactions in vivo by site-specific genome engineering (2014) (77)
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics (2016) (76)
Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment (2014) (75)
Cdc45: the missing RecJ ortholog in eukaryotes? (2011) (75)
AF-6/cno: neither a kinesin nor a myosin, but a bit of both. (1995) (75)
Duplication and positive selection among hominin-specific PRAME genes (2005) (74)
Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs (2012) (70)
Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide. (1998) (70)
OPR, PC and AID: all in the PB1 family. (2002) (67)
CBS domains in CIC chloride channels implicated in myotonia and nephrolithiasis (kidney stones). (1997) (67)
Meisetz and the birth of the KRAB motif (2006) (65)
Preparation of high-quality next-generation sequencing libraries from picogram quantities of target DNA. (2012) (65)
A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway (2014) (64)
A SNP Map of the Rat Genome Generated from cDNA Sequences (2004) (64)
Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins (1999) (64)
Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I (2013) (64)
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression (2013) (63)
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases* (2016) (63)
Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders? (2001) (62)
Identification of homer as a homologue of the Wiskott-Aldrich Syndrome protein suggests a receptor-binding function for WH1 domains (1997) (62)
Acid sphingomyelinase possesses a domain homologous to its activator proteins: Saposins B and D (1994) (61)
Protein families in multicellular organisms. (1999) (61)
Issues in Predicting Protein Function From Sequence (2001) (58)
Genome assembly quality: assessment and improvement using the neutral indel model. (2010) (58)
Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla (2016) (57)
Mutations within lncRNAs are effectively selected against in fruitfly but not in human (2013) (57)
CGAT: computational genomics analysis toolkit (2014) (56)
Network Topologies and Convergent Aetiologies Arising from Deletions and Duplications Observed in Individuals with Autism (2013) (56)
The Human Cell Atlas White Paper (2018) (55)
Accurate Distinction of Pathogenic from Benign CNVs in Mental Retardation (2010) (55)
Cytoplasmic signalling domains: the next generation. (1997) (54)
A common ancestry for BAP1 and Uch37 regulators (2012) (54)
Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands (2018) (54)
Crosstalking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7 (2014) (54)
The domain organization of streptokinase: Nuclear magnetic resonance, circular dichroism, and functional characterization of proteolytic fragments (1996) (54)
Temporal transcriptomics suggest that twin-peaking genes reset the clock (2015) (53)
Identification and function of long non-coding RNAs. (2013) (52)
Hotspots of mutation and breakage in dog and human chromosomes. (2005) (51)
More than 1,000 putative new human signalling proteins revealed by EST data mining (2000) (51)
Comparative evolutionary genomics of androgen-binding protein genes. (2004) (50)
Protein fold irregularities that hinder sequence analysis. (1998) (49)
TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease (2014) (48)
Identification and functional analysis of an ovarian form of the egg activation factor phospholipase C zeta (PLCζ) in pufferfish (2011) (48)
Forging Links between Human Mental Retardation–Associated CNVs and Mouse Gene Knockout Models (2009) (47)
Signatures of adaptive evolution within human non-coding sequence. (2006) (47)
Insights into the evolution of Darwin’s finches from comparative analysis of the Geospiza magnirostris genome sequence (2013) (46)
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals (2008) (45)
P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease (1997) (45)
Human platelet‐derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase (1992) (45)
Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex (2015) (44)
An analysis of the gene complement of a marsupial, Monodelphis domestica: evolution of lineage-specific genes and giant chromosomes. (2007) (44)
Variable Strength of Translational Selection Among 12 Drosophila Species (2007) (43)
Porcine natural-killer-enhancing factor-B: oligomerisation and identification as a calpain substrate in vitro. (1998) (43)
PDZ domains in bacterial proteins (1997) (42)
Laplacian eigenmaps and principal curves for high resolution pseudotemporal ordering of single-cell RNA-seq profiles (2015) (42)
Cadherin-like domains in α-dystroglycan, α/ε-sarcoglycan and yeast and bacterial proteins (2002) (42)
The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis (2018) (40)
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer (2014) (39)
Biological function in the twilight zone of sequence conservation (2017) (37)
The compact domain conformation of human Glu-plasminogen in solution. (1992) (37)
Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing (2019) (37)
Analysis of the interactions between streptokinase domains and human plasminogen (1998) (37)
Eukaryotic domain evolution inferred from genome comparisons. (2003) (36)
The N‐terminal domains of tensin and auxilin are phosphatase homologues (1996) (36)
Nprl3 is required for normal development of the cardiovascular system (2012) (35)
Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex* (2012) (35)
Sequence variation and disease in the wake of the draft human genome. (2001) (34)
Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad (2016) (34)
Rapid Evolution of Beta-Keratin Genes Contribute to Phenotypic Differences That Distinguish Turtles and Birds from Other Reptiles (2013) (34)
Wrangling for microRNAs provokes much crosstalk (2011) (33)
Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA 7 (33)
OPTIC: orthologous and paralogous transcripts in clades (2007) (33)
Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus (2005) (32)
UBA domain containing proteins in fission yeast. (2003) (32)
The phenotypic spectrum of Xia‐Gibbs syndrome (2018) (30)
Conformational stability studies of the pleckstrin DEP domain: definition of the domain boundaries. (1998) (30)
Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype (2014) (29)
TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules (2017) (29)
Candidate testis‐determining gene, Maestro (Mro), encodes a novel HEAT repeat protein (2003) (29)
Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins. (2002) (29)
Thermal stability of the three domains of streptokinase studied by circular dichroism and nuclear magnetic resonance (1996) (29)
Mammalian BEX, WEX and GASP genes: Coding and non-coding chimaerism sustained by gene conversion events (2005) (29)
The long and the short of RNA maps. (2007) (29)
The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity (2019) (29)
Analysis of mutations in the tudor domain of the survival motor neuron protein SMN (1999) (28)
Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease. (2019) (27)
Genes and homology (2004) (27)
Identification of genetic variants affecting vitamin D receptor binding and associations with autoimmune disease (2017) (25)
Cofilin-1: A Modulator of Anxiety in Mice (2012) (25)
GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial gliding. (2004) (24)
Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease (2017) (24)
Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review. (2022) (24)
Identification of functional long non-coding RNAs in C. elegans (2018) (24)
Genes and biological processes commonly disrupted in rare and heterogeneous developmental delay syndromes. (2011) (23)
The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7 (2019) (23)
THE BIOLOGY OF GENOMES (2010) (23)
Plagiarized bacterial genes in the human book of life. (2001) (23)
Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby (2011) (22)
Rapid turnover of functional sequence in human and other genomes. (2011) (22)
Foxn 1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells (2016) (22)
Pion production by pions in the 16O(π+,π+π−) reaction at Tπ+ = 280 MeV (1989) (21)
Integrin α- and β4-subunit-domain homologues in cyanobacterial proteins (1999) (20)
Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi. (2006) (20)
Squamous cell carcinoma in a child with Clericuzio‐type poikiloderma with neutropenia (2013) (20)
Insights into the post-transcriptional regulation of the mitochondrial electron transport chain (2016) (19)
Sequence analysis of multidomain proteins: past perspectives and future directions. (2002) (19)
Glycosylation at Asn‐289 facilitates the ligand‐induced conformational changes of human Glu‐plasminogen (1997) (19)
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits (2020) (19)
Structure and evolutionary history of DISC1. (2011) (19)
Genetic risk factors of ME/CFS: a critical review (2020) (18)
A β‐propeller domain within TolB (1999) (18)
Identification of molecular signatures specific for distinct cranial sensory ganglia in the developing chick (2016) (17)
The Anolis Lizard Genome: An Amniote Genome without Isochores (2011) (17)
REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans (2015) (17)
Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development (2018) (17)
Substitution of arginine 719 for glutamic acid in human plasminogen substantially reduces its affinity for streptokinase. (1994) (16)
Separating derived from ancestral features of mouse and human genomes. (2009) (16)
beta-propeller repeats and a PDZ domain in the tricorn protease: predicted self-compartmentalisation and C-terminal polypeptide-binding strategies of substrate selection. (1999) (16)
Identification of domains from protein sequences. (2000) (16)
No gene in the genome makes sense except in the light of evolution. (2014) (16)
The role of ADP-ribosylation in regulating DNA interstrand crosslink repair (2016) (15)
Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene (2002) (14)
Brain-expressed 3′UTR extensions strengthen miRNA cross-talk between ion channel/transporter encoding mRNAs (2014) (14)
ELIXIR-UK role in bioinformatics training at the national level and across ELIXIR (2017) (13)
Citrullination Was Introduced into Animals by Horizontal Gene Transfer from Cyanobacteria (2020) (13)
Molecular characterisation of a thermoactive beta-1,3-glucanase from Oerskovia xanthineolytica. (1996) (13)
Genome cartography through domain annotation (2001) (12)
Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase. (2010) (12)
Pleckstrin's repeat performance (1996) (12)
Tiki, at the head of a new superfamily of enzymes (2013) (12)
Accelerated evolution of PAK3- and PIM1-like kinase gene families in the zebra finch, Taeniopygia guttata. (2010) (12)
Corrigendum: Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7 (2015) (11)
Multinucleon pion absorption in the He4(,ppp)n reaction (1991) (11)
Porcine natural-killer-enhancing factor-B (1998) (11)
Evolutionary biology: Human brain gene wins genome race (2006) (11)
Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19 (2021) (11)
The Human Cell Atlas: making ‘cell space’ for disease (2019) (10)
Author response: The Human Cell Atlas (2017) (10)
Accurate estimation of gene evolutionary rates using XRATE, with an application to transmembrane proteins. (2009) (10)
Is the control of recombination conserved among diverse eukaryotes? (2011) (9)
A gene expression signature in developing Purkinje cells predicts autism and intellectual disability co-morbidity status (2019) (9)
The GAF domain (1997) (8)
Sixty years of genome biology (2013) (8)
Multi-nucleon pion absorption in the 4He(π+,ppp)n reaction (1989) (8)
A lipid-binding domain in Wnt: a case of mistaken identity? (1999) (8)
Corrigendum: Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells. (2015) (7)
An open and transparent process to select ELIXIR Node Services as implemented by ELIXIR-UK (2016) (6)
Refining the domain architecture model of the replication origin firing factor Treslin/TICRR (2021) (6)
Crystallization and X-ray diffraction study of recombinant platelet-derived endothelial cell growth factor. (1993) (6)
Erratum: Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7 (Nature Structural and Molecular Biology (2014) 21 (955-961)) (2015) (6)
The RFTS Domain of Raf2 Is Required for Cul4 Interaction and Heterochromatin Integrity in Fission Yeast (2014) (6)
Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression (2022) (6)
Comparative genomics of vertebrates (2005) (5)
Extending the Horizon of Homology Detection with Coevolution-based Structure Prediction (2021) (5)
FAM111A regulates replication origin activation and cell fitness (2020) (5)
CGAT: a model for immersive personalized training in computational genomics (2015) (5)
Rapsyn's knobs and holes (1996) (5)
Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain (2016) (5)
Correction: The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity (2019) (4)
Considerations when investigating lncRNA function (2014) (4)
Integrin alpha- and beta 4-subunit-domain homologues in cyanobacterial proteins. (1999) (4)
The breast cancer gene product TSG101 (1997) (4)
Hexa-Longin domain scaffolds for inter-Rab signalling (2019) (4)
Cerox1 and microRNA-488-3p noncoding RNAs jointly regulate mitochondrial complex I catalytic activity (2018) (4)
THoR: a tool for domain discovery and curation of multiple alignments (2003) (4)
Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits (2019) (4)
Accelerated Evolution of PAK 3-and PIM 1-like Kinase Gene Families in the Zebra Finch , Taeniopygia guttata (2010) (3)
Brain, Know Thy Transcriptome, Know Thyself (2012) (3)
Functional RNA classes: a matter of time? (2017) (3)
Molecularly distinct astrocyte subpopulations spatially pattern the adult mouse brain (2018) (3)
Loaded Dice for Human Genome Mutation (2012) (3)
An open and transparent process to select ELIXIR Node Services as implemented by ELIXIR-UK. (2016) (3)
Phospholipases A2 and Wnts are unlikely to share a common ancestor. (1999) (3)
Frontiers in Computational Genomics (2003) (3)
AF-6/cno (1995) (3)
High levels of RNA-editing site conservation amongst 15 laboratory mouse strains (2012) (3)
15-P038 Stra6.2: A novel member of the STRA6 gene family (2009) (2)
The Cdk 8 / 19-cyclin C transcription regulator functions in genome replication through metazoan Sld 7 (2019) (2)
DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndrome (2022) (2)
Ependymal cell maturation is heterogeneous and ongoing in the mouse spinal cord and dynamically regulated in response to injury (2022) (2)
Protein Sequence Analysis and Domain Identification (2005) (2)
Report on the training needs identified across the ELIXIR community (2016) (2)
Faculty Opinions recommendation of Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. (2005) (2)
Statistical Genetics: Usual suspects in complex disease (2005) (2)
Cytoplasmic signalling domains (1997) (2)
Author response: Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery (2014) (2)
A novel glycosyltransferase is mutated in a form of congenital muscular dystrophy with secondary laminin alpha 2 deficiency and abnormal glycosylation of alpha-dystroglycan (2001) (2)
The genomic landscape shaped by selection on transposable elements across 18 mouse strains (2012) (2)
Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes (2015) (2)
Explorer TMEM 132 : an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules (2017) (2)
Big knowledge from big data in functional genomics (2017) (2)
No Sec7-homology domain in guanine-nucleotide-exchange factors that act on Ras and Rho. (1999) (1)
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage (2013) (1)
Mammalian Genes and Evolutionary Genomics (2005) (1)
Identifi cation and function of long non-coding RNAs (2013) (1)
Authors and affiliations (2013) (1)
Author response: The long non-coding RNA Dali is an epigenetic regulator of neural differentiation (2014) (1)
proteins SAM : A novel motif in yeast sterile and Drosophila polyhomeotic (1995) (1)
Mutations within lncRNAs are effectively selected against in fruitfly but not in human (2013) (1)
Predicting the Evolution, Structure and Function of Proteins from Sequence Information (1997) (1)
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer (2014) (1)
Decision letter: Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming (2018) (1)
Author response: Diagnostically relevant facial gestalt information from ordinary photos (2014) (1)
OAF: a new member of the BRICHOS family (2022) (1)
Author Correction: Comparative and demographic analysis of orang-utan genomes (2022) (1)
A Genome-wide association study of non-pathological cognitive ageing (2012) (1)
Elevated gene expression of most microglial markers, and reduced expression of most pyramidal neuron and interneuron markers, in postmortem autism cortex (2015) (1)
A lipid-binding domain in Wnt (1999) (1)
Most of the 6.5% - 10% of human DNA bases that are functional now will soon be turned over (2010) (0)
Biological function in the twilight zone of sequence conservation (2017) (0)
Decision letter: PUMILIO hyperactivity drives premature aging of Norad-deficient mice (2018) (0)
CNVs in human genomes (2009) (0)
Identification of a Major Gene (RP25) for Autosomal Recessive Retinitis Pigmentosa (2008) (0)
The signalling domain repertoire - (TIBSC 04) (1997) (0)
PERCC1, a new member of the Yap/TAZ/FAM181 transcriptional co-regulator family (2022) (0)
An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury. (2023) (0)
Identification and characterization of a novel family of presenilin homologues (2002) (0)
A measurement of the analysing power of the pn --> pp(¹⁰)⁻ reaction (1988) (0)
46% of individuals with ASD that harbour de novo CNVs have at least one de novo CNV that overlaps a gene associated with synaptic signalling (2010) (0)
Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s esophagus and esophageal glands (2018) (0)
Decision letter: Information content differentiates enhancers from silencers in mouse photoreceptors (2021) (0)
Transcriptional brain networks and their key regulators across the human lifespan (2014) (0)
LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone) (1996) (0)
Contents: Eur. J. Immunol. 4'16. (2016) (0)
venom genes Defensins and the convergent evolution of platypus and reptile Material Supplemental (2008) (0)
A coming of age for bioinformatics (2003) (0)
Researchevolution of genes in avian genomes (2010) (0)
Whole genome sequencing reveals host factors underlying critical Covid-19 Accelerated Article Preview (2022) (0)
Comparative approaches to the genetics of human neuropsychiatric disorders (2012) (0)
Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands (2018) (0)
SeMet derivative of BbCRASP-1 from Borrelia Burgdorferi (2005) (0)
Identification of novel genes involved in spinal muscular atrophy using high density microarrays (2002) (0)
Movie S1. GFP:Repo-Man 403–1023 Localizes to Bulk Chromatin after Anaphase Onset (2011) (0)
Explorer The RFTS domain of Raf 2 is required for Cul 4 interaction and heterochromatin integrity in fission yeast (2017) (0)
Analyses of functional sequence in mammalian and avian genomes (2014) (0)
Identification of functional non-coding transcribed sequences in Eukaryotes species (2017) (0)
Faculty Opinions recommendation of A high-resolution survey of deletion polymorphism in the human genome. (2006) (0)
O-236 A multi-omics genome-plus-transcriptome single-cell atlas of human pre-implantation development reveals the impact of chromosome instability on cell function within the embryo (2022) (0)
Identifying causative elements within structural variants associated with developmental disorders (2013) (0)
Ki-67, a PP1 interacting protein and chromosome periphery organizer (2012) (0)
Single cell transcriptomes from mouse cerebellum (2016) (0)
Typing myalgic encephalomyelitis by infection at onset: A DecodeME study (2023) (0)
Evolution and function of long noncoding RNAs in Drosophila (2011) (0)
Movie S2. GFP:Repo-Man1–397 Localizes to the Chromosomes Periphery in Telophase (2011) (0)
Author response: Considerations when investigating lncRNA function in vivo (2014) (0)
Insights into the evolution of Darwin’s finches from comparative analysis of the Geospiza magnirostris genome sequence (2013) (0)
Erratum: Comparative evolutionary genomics of androgen-binding protein genes (Genome Research (2004) vol. 14 (1516-1529)) (2004) (0)
Plasminogen variants and streptokinase binding. (1996) (0)
GOBLET: achievements and goals a year on (2014) (0)
Advisory Board and Contents (2020) (0)
Application of the Neutral Indel Model to genome sequences for diverse metazoans (2010) (0)
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity (2021) (0)
The genetics of ME: A commentary on Hajdarevic et al. (2022) (0)
Candidate genes and biological processes in de novo CNVs from autistic individuals (2010) (0)
Explorer Mouse genomic variation and its effect on phenotypes and gene regulation (2017) (0)
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity (2021) (0)
Dynamics of Transcriptional Coexpression Brain Networks Over the Human Lifespan (2013) (0)
The long non-coding RNA Dali is an epigenetic regulator of neural 2 differentiation (0)
A gene expression signature in developing Purkinje cells predicts autism and intellectual disability co-morbidity status (2019) (0)
Author response: Ageing compromises mouse thymus function and remodels epithelial cell differentiation (2020) (0)
Faculty Opinions recommendation of Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup. (2006) (0)
Symposium (2005) (0)
Whole genome sequencing identiﬁes multiple loci for critical 1 illness caused by COVID-19 2 (2021) (0)
Paupar LncRNA Promotes KAP1 Dependent Chromatin Changes And Regulates Subventricular Zone Neurogenesis (2017) (0)
Advisory Board and Contents (2020) (0)
Erratum: The long and the short of RNA maps (BioEssays 29, 11, (1077-1080)) (2007) (0)
Faculty Opinions recommendation of A second class of chemosensory receptors in the olfactory epithelium. (2006) (0)
The histone chaperone activity of SPT2 controls chromatin structure and function in Metazoa (2023) (0)
Mutations in TOPORS Cause Autosomal Dominant Retinitis Pigmentosa with Perivascular RPE Atrophy (2018) (0)
Crystallization and X-ray diffraction studies of recombinant human platelet-derived endothelial cell growth factor (1993) (0)
Identification of molecular signatures specific for distinct cranial sensory ganglia in the developing chick (2016) (0)
Identification of functional long non-coding RNAs in C. elegans (2019) (0)
Quantitative gene expression profiling with targeted RNA sequencing (2014) (0)
From Copy Number Identification to Copy Number Interpretation and back again (2010) (0)
Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAs (2013) (0)
Nprl3 is required for normal development of the cardiovascular system (2012) (0)
Sixty years of genome biology (2013) (0)
Single cell transcriptomes from mouse hippocampus (2016) (0)
Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs (2012) (0)
BbCRASP-1 from Borrelia Burgdorferi (2005) (0)
Faculty Opinions recommendation of Transposable element derived DNaseI-hypersensitive sites in the human genome. (2006) (0)
' s response to reviews Title : Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre-and post-treatment prostatic biopsies from patients with advanced prostate cancer (2014) (0)
Genetics Needs Non-geneticists. (2020) (0)
POMD09 Understanding the early pathological pathways in Parkinson's disease. The Oxford Parkinson's Disease Centre (2010) (0)
Birth, death or fixation of human segmental duplications (2007) (0)
Genetic control of KRAB-ZFP genes explains distal CpG-site methylation which associates with human disease phenotypes (2022) (0)
The painted turtle genome: The evolution of extreme physiological (2013) (0)
The ELIXIR training platform: highlights and overview (2016) (0)
Dispensing with unnecessary assumptions in population genetics analysis (2023) (0)
Author response: KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands (2012) (0)
Abstract 714: Mapping the Transcriptional Dynamics of Pluripotent Stem Cell-derived Endothelial Cell Differentiation by Single Cell RNA Sequencing (2019) (0)
Differential expression and functions of protein-coding and noncoding genes across mouse neocortical layers (2011) (0)

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