Christian Pike
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Most Influential Person Now
American scientist
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Physics
Christian Pike's Degrees
- PhD Physics Stanford University
- Masters Physics Stanford University
- Bachelors Physics Stanford University
Why Is Christian Pike Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christian Pike is a professor at the Leonard Davis School of Gerontology and a member of the USC Neuroscience Program. His ongoing work focuses on Alzheimer's disease and other age-related neurodegenerative disorders. His laboratory studies the role of neuronal apoptosis in neural diseases. Recently, his research found new use for synthetic estrogens in lessening the effects of Hormone Replacement Therapy for Alzheimer's patients.
Christian Pike's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state (1993) (1436)
- Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. (1993) (1050)
- In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity (1991) (812)
- Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity (1995) (646)
- Progesterone receptors: Form and function in brain (2008) (525)
- Protective actions of sex steroid hormones in Alzheimer’s disease (2009) (445)
- Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease. (2001) (403)
- Estrogen and exercise interact to regulate brain‐derived neurotrophic factor mRNA and protein expression in the hippocampus (2001) (339)
- Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities (1997) (302)
- Progesterone and Estrogen Regulate Alzheimer-Like Neuropathology in Female 3xTg-AD Mice (2007) (302)
- β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease (1996) (299)
- Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. (1991) (291)
- Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro(*) (1995) (279)
- Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. (1995) (247)
- Sex and the development of Alzheimer's disease (2017) (242)
- Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease (2011) (242)
- In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. (1991) (229)
- β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w (2005) (206)
- Gender, sex steroid hormones, and Alzheimer's disease (2013) (206)
- Rapid Communication: Ca2+ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture (1994) (200)
- Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure (2010) (199)
- Early association of reactive astrocytes with senile plaques in Alzheimer's disease (1995) (191)
- Androgens activate mitogen‐activated protein kinase signaling: Role in neuroprotection (2005) (182)
- Age-related testosterone depletion and the development of Alzheimer disease. (2004) (179)
- Sex hormones, aging, and Alzheimer's disease. (2012) (176)
- Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons (2001) (176)
- beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. (1992) (147)
- β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease (1994) (146)
- Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons. (2007) (145)
- β‐Amyloid Neurotoxicity In Vitro: Evidence of Oxidative Stress but Not Protection by Antioxidants (1997) (141)
- Androgens Regulate the Development of Neuropathology in a Triple Transgenic Mouse Model of Alzheimer's Disease (2006) (138)
- Differential Induction of Immediate Early Gene Proteins in Cultured Neurons by β‐Amyloid (Aβ): Association of c‐Jun with Aβ‐Induced Apoptosis (1995) (138)
- Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells (1996) (137)
- Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions (2014) (132)
- Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons (1994) (130)
- Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease (2012) (125)
- Androgen cell signaling pathways involved in neuroprotective actions (2008) (120)
- Surface determinants of neuronal survival and growth on self-assembled monolayers in culture (1993) (120)
- β-Amyloid neurotoxicity: A discussion of in vitro findings (1992) (119)
- Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. (1996) (118)
- Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death (2007) (113)
- Androgens modulate β‐amyloid levels in male rat brain (2003) (113)
- Estrogen activates protein kinase C in neurons: role in neuroprotection (2003) (112)
- Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture. (1994) (111)
- Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro. (1995) (110)
- Androgens modulate neuronal vulnerability to kainate lesion (2003) (104)
- Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways (2010) (103)
- Age-related changes in neuroactive steroid levels in 3xTg-AD mice (2013) (94)
- Thrombin Attenuates Neuronal Cell Death and Modulates Astrocyte Reactivity Induced by β‐Amyloid In Vitro (1996) (92)
- Rational pattern design for in vitro cellular networks using surface photochemistry (1994) (91)
- Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease (2013) (89)
- Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons. (2001) (89)
- β-Amyloid peptides induce degeneration of cultured rat microglia (1993) (87)
- Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid (1993) (86)
- Androgen regulation of β-amyloid protein and the risk of Alzheimer's disease (2008) (85)
- Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice. (2008) (83)
- Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. (2010) (78)
- Menopause, obesity and inflammation: interactive risk factors for Alzheimer’s disease (2015) (78)
- All-D-Enantiomers of β-Amyloid Exhibit Similar Biological Properties to All-L-β-Amyloids* (1997) (77)
- Interactions between inflammation, sex steroids, and Alzheimer’s disease risk factors (2016) (75)
- Androgens regulate neprilysin expression: role in reducing β‐amyloid levels (2008) (74)
- The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice (2016) (71)
- The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity (2015) (71)
- Neuroprotective properties of selective estrogen receptor agonists in cultured neurons (2005) (69)
- Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus (2006) (67)
- Progesterone inhibits estrogen‐mediated neuroprotection against excitotoxicity by down‐regulating estrogen receptor‐β (2010) (66)
- Androgens Selectively Protect Against Apoptosis in Hippocampal Neurones (2010) (65)
- Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion (2003) (65)
- Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function (2014) (62)
- Androgens, aging, and Alzheimer's disease (2006) (62)
- Obesity and sex interact in the regulation of Alzheimer's disease (2016) (61)
- Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. (2007) (61)
- Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice (2017) (60)
- 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. (2012) (58)
- Calretinin-immunoreactive neurons are resistant to β-amyloid toxicity in vitro (1995) (57)
- The Oxygen Paradox, the French Paradox, and age-related diseases (2017) (57)
- Continuous versus Cyclic Progesterone Exposure Differentially Regulates Hippocampal Gene Expression and Functional Profiles (2012) (56)
- Progesterone Attenuates Oestrogen Neuroprotection Via Downregulation of Oestrogen Receptor Expression in Cultured Neurones (2009) (53)
- Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans (2018) (49)
- Androgens modulate beta-amyloid levels in male rat brain. (2003) (49)
- Attenuation of β‐Amyloid Neurotoxicity In Vitro by Potassium‐Induced Depolarization (1996) (47)
- Estrogen regulates bcl-x expression in rat hippocampus (2001) (47)
- APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice (2019) (43)
- Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease. (2008) (42)
- Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice (2012) (41)
- Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats (2008) (41)
- Caspase activation contributes to astrogliosis (2012) (41)
- Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons (2009) (37)
- Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. (1994) (34)
- TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity (2018) (33)
- Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease. (1994) (32)
- Age-related changes in serum and brain levels of androgens in male Brown Norway rats (2009) (31)
- Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen (2006) (30)
- Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice (2017) (24)
- Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. (1995) (24)
- Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. (2014) (23)
- TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice (2018) (22)
- Apoptosis in Alzheimer’s Disease (1998) (20)
- β-Amyloid Increases Enzyme Activity and Protein Levels of Glutamine Synthetase in Cultured Astrocytes (1996) (19)
- Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons (2014) (17)
- The influence of the carboxyl terminus of the Alzheimer Aβ peptide on its conformation, aggregation, and neurotoxic properties (2002) (17)
- Estrogen Modulates Neuronal Bcl‐xl Expression and β‐Amyloid‐Induced Apoptosis (1999) (16)
- The synthetic estrogen 4-estren-3α,17β-diol (estren) induces estrogen-like neuroprotection (2005) (16)
- APOE genotype affects metabolic and Alzheimer‐related outcomes induced by Western diet in female EFAD mice (2018) (14)
- Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats (2019) (14)
- Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice (2020) (13)
- Adaptive versus pathological plasticity. Possible contributions to age-related dementia. (1993) (11)
- The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. (2005) (8)
- Deconvolution of the confounding variations for reverse transcription quantitative real-time polymerase chain reaction by separate analysis of biological replicate data. (2012) (7)
- Dementia risk in women higher in same‐sex than opposite‐sex twins (2020) (7)
- Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro. (1995) (6)
- Microglial transcription profiles in mouse and human are driven by APOE4 and sex (2021) (6)
- Impact of continuous versus discontinuous progesterone on estradiol regulation of neuron viability and sprouting after entorhinal cortex lesion in female rats. (2015) (5)
- Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase–Protein Kinase B–Glycogen Synthase Kinase 3β Signaling (2022) (5)
- Hormones, Cognition and Dementia: Testosterone regulates Alzheimer's disease pathogenesis (2009) (4)
- Second to fourth digit ratio (2D:4D) is associated with dementia in women. (2020) (4)
- Staining and Quantification of β-Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease. (2020) (3)
- Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models (2022) (3)
- Androgens regulate tau phosphorylation through PI3K-Akt-GSK3β signaling. (2022) (3)
- Sex-specific Effects of a High Fat Diet on Indices of Metabolic Syndrome in 3xTgAD Mice: Implications for Alzheimer's Disease (2010) (2)
- P1-435: Selective estrogen receptor modulators differentially regulate Alzheimer-like neuropathology in female triple transgenic mice (2008) (2)
- Role of estrogen in women's Alzheimer's disease risk as modified by APOE (2022) (2)
- 423 β-Amyloid neurotoxicity in vitro: Examination of potential contributions by oxidative pathways (1996) (1)
- Ligand for translocator protein increases hippocampal expression of glial beta-amyloid scavenger receptors and reduces beta-amyloid in male mice and rats (2013) (1)
- Continuous and cyclic progesterone differentially affect estrogen regulation of Alzheimer-like pathology in female 3xTg-AD mice (2009) (1)
- Obesity and low testosterone interact to increase vulnerability to Alzheimer's disease pathogenesis (2013) (1)
- APOPTOSIS IN ALZHEIMER'S DISEASE Inductive Agents and Antioxidant Protective Factors (1998) (1)
- Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function (2014) (1)
- Neuroprotective effects of the selective androgen receptor modulator RAD140 in cultured neurons and kainate lesioned rats (2013) (0)
- SHORT-TERM DIESEL EXHAUST PARTICLE NEUROTOXICITY MEDIATED BY TLR4 ACROSS AGE AND SEX (2022) (0)
- The Oxygen Paradox, the French Paradox, and age-related diseases (2017) (0)
- Effects of APOE Genotype and Western Diet on Metabolic Phenotypes in Female Mice (2023) (0)
- Dietary induction of type 2 diabetes increases AD-like pathology in male 3xTg-AD mice (2009) (0)
- THE ROLE OF STEROID BIOSYNTHESIS IN THE PROTECTIVE ACTIONS OF LIGANDS FOR THE TRANSLOCATOR PROTEIN (TSPO) (2014) (0)
- Dementia and Testosterone Levels in Men—Reply (2005) (0)
- PROTECTIVE EFFECTS OF ESTRADIOL ON METABOLIC AND NEURAL EFFECTS OF OBESITY IN FEMALE APOE3 AND APOE4 MICE AT EARLY MIDDLE AGE (2019) (0)
- Relative digit length is associated with cognitive abilities in women and men (2020) (0)
- Apoptosis is induced by fB-amyloid in cultured central nervous system neurons ( Alzheiner / prgrammed cell death / neurodegeneration ) (2005) (0)
- Author's response to commentaries (1996) (0)
- Protection against APOE4-associated aging phenotypes with a longevity-promoting intervention (2021) (0)
- APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice (2022) (0)
- Effects of APOE genotype and estrogen status on brain transcriptome in female mice (2021) (0)
- INVESTIGATING THE NEURAL AFFECTS OF 17 ALPHA-ESTRADIOL (17Α-E2) ON APOE4 PHENOTYPES (2022) (0)
- TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity (2018) (0)
- APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice (2019) (0)
- Diet-induced obesity and low testosterone interact to increase neuroinflammation and reduce neuron survival (2013) (0)
- 17alpha‐estradiol improves systemic and neural outcomes in middle‐aged APOE4 mice (2021) (0)
- Investigating the Correlation between 2 D : 4 D Ratio and Risk for Alzheimer ’ s Disease (2013) (0)
- Dementia and testosterone levels in men. Authors' reply (2005) (0)
- Protection against APOE4-associated aging phenotypes with a longevity-promoting intervention (2021) (0)
- MICROGLIAL INTERACTIONS WITH AMYLOID PLAQUES ARE MODULATED BY SEX AND APOE GENOTYPE IN EFAD MICE (2019) (0)
- Short communication E increases the vulnerability of rat hippocampal neurons to kainate lesion (2003) (0)
- TRANSCRIPTOMIC PROFILING OF MICROGLIA FROM AN ALZHEIMER'S DISEASE MOUSE MODEL AND FROM HUMAN INDUCED PLURIPOTENT STEM CELLS REVEALS EFFECTS OF THE APOE4 GENOTYPE (2019) (0)
- Progesterone regulation of neuroprotective estrogen actions (2009) (0)
- P1-252 Androgens regulate development of neuropathology in a mouse model of Alzheimer’s disease (2006) (0)
- The longevity‐promoting intervention 17α‐Estradiol protects against aging phenotypes in APOE4 mice (2022) (0)
- Poster Sessions BP06: Alzheimer's Disease (2003) (0)
- Higher digit ratio (2D:4D) associated with dementia in women (2020) (0)
- Dietary induction of type 2 diabetes increases Alzheimer-like pathology in male 3xTg-AD mice (2009) (0)
- SEX DIFFERENCES IN DEMENTIA RISK: THE EFFECTS OF PRENATAL TESTOSTERONE EXPOSURE, APOE4, AND THEIR INTERACTION (2019) (0)
- O4-02-07: Androgens but not leuprolide protect against Abeta accumulation in male triple transgenic mice (2008) (0)
- 722 Multiple neuropathological variables are correlated with the level of cognitive impairment in Alzheimer's disease (1996) (0)
- Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans (2018) (0)
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