Christian Thomsen
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Christian Thomsenbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Chemistry Biology
Christian Thomsen's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry Stanford University
- Bachelors Chemistry Stanford University
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(Suggest an Edit or Addition)Christian Thomsen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins (1993) (688)
- CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. (1999) (331)
- Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. (2001) (238)
- The role of the innate immune system in psychiatric disorders (2013) (234)
- Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. (2005) (227)
- Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. (1997) (178)
- Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB‐1893 and MPEP (2003) (171)
- 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. (1995) (159)
- Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family. (1994) (123)
- A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover (1993) (120)
- (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. (1996) (116)
- L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase (1992) (113)
- Distribution and pharmacology of alanine–serine–cysteine transporter 1 (asc‐1) in rodent brain (2003) (110)
- Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators. (2005) (102)
- A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line (1993) (88)
- Delayed myelination in a mouse model of fragile X syndrome. (2013) (82)
- Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. (1996) (80)
- Probing the Ligand-binding Domain of the mGluR4 Subtype of Metabotropic Glutamate Receptor* (1999) (70)
- Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice (1998) (64)
- 1‐(3‐(9H‐Carbazol‐9‐yl)‐1‐propyl)‐4‐(2‐methoxyphenyl)‐4‐piperidinol, a novel subtype selective inhibitor of the mouse type II GABA‐transporter (1997) (62)
- l‐Glutamate Uptake Inhibitors May Stimulate Phosphoinositide Hydrolysis in Baby Hamster Kidney Cells Expressing mGluR1a via Heteroexchange with l‐Glutamate Without Direct Activation of mGluR1a (1994) (61)
- Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor (1993) (61)
- N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects. (1999) (60)
- Asc‐1 Transporter Regulation of Synaptic Activity via the Tonic Release of d‐Serine in the Forebrain (2016) (57)
- Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter‐1 (GlyT1) (2008) (56)
- Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents. (1999) (54)
- Astroglia Contain a Specific Transport Mechanism for N‐Acetyl‐l‐Aspartate (1999) (54)
- (S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice (1994) (50)
- Cloning and Characterization of a Metabotropic Glutamate Receptor, mGluR4b (1997) (49)
- Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1 (1997) (48)
- Modulation of seizure activity in mice by metabotropic glutamate receptor ligands. (1996) (48)
- (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors. (1996) (46)
- [3H]‐L‐2‐amino‐4‐phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a (1995) (45)
- Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice. (2000) (42)
- The L-AP4 receptor. (1997) (40)
- (8‐Naphthalen‐1‐ylmethyl‐4‐oxo‐1‐phenyl‐1,3,8‐triaza‐spiro[4.5]dec‐3‐yl)‐acetic acid methyl ester (NNC 63‐0532) is a novel potent nociceptin receptor agonist (2000) (39)
- Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models. (1993) (39)
- Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice. (1999) (34)
- Synthesis and biological evaluation of novel carbon-11-labelled analogues of citalopram as potential radioligands for the serotonin transporter. (2003) (32)
- ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. (2002) (32)
- Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes (1994) (32)
- Persistent astrocyte activation in the fragile X mouse cerebellum (2015) (31)
- Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. (1993) (31)
- Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells. (1998) (30)
- Contribution of Metabotropic Glutamate Receptor mGluR4 to L‐2‐[3H]Amino‐4‐Phosphonobutyrate Binding in Mouse Brain (1999) (30)
- Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity. (1998) (29)
- L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase. (1993) (28)
- Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography. (2004) (26)
- Lu 28-179 labels a σ2-site in rat and human brain (2002) (26)
- [3H]ac-RYYRWK-NH2, a novel specific radioligand for the nociceptin/orphanin FQ receptor (2000) (25)
- Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. (2006) (25)
- Synthesis and Preliminary Biological Evaluation of 2′‐Substituted 2‐(3′‐Carboxybicyclo[1.1.1]pentyl)glycine Derivatives as Group I Selective Metabotropic Glutamate Receptor Ligands (2006) (24)
- 4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors. (1993) (23)
- Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats. (1998) (23)
- Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA) (1996) (23)
- The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles. (1998) (22)
- Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signaling after pertussis toxin treatment. (1997) (21)
- Metabotropic glutamate receptor subtype 1a activates adenylate cyclase when expressed in baby hamster kidney cells (1996) (20)
- Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. (2009) (19)
- Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. (2006) (19)
- Effects of chronic tiagabine treatment on [3H]GABAA, [3H]GABAB and [3H]tiagabine binding to sections from mice brain (1995) (18)
- Increased insulin secretion and normalization of glucose tolerance by cholinergic agonism in high fat-fed mice. (1999) (18)
- Glycine transporter inhibitors as novel antipsychotics (2006) (17)
- Autoradiographic visualization of group III metabotropic glutamate receptors using [3H]‐L‐2‐amino‐4‐phosphonobutyrate (1998) (17)
- Regional pattern of binding and c-Fos induction by (R)- and (S)-citalopram in rat brain (2003) (17)
- Effects of t-ACPD on neural survival and second messengers in cultured cerebral cortical neurones. (1993) (16)
- Lu 28-179 labels a sigma(2)-site in rat and human brain. (2002) (16)
- Synthesis of 3‐Hydroxy‐ and 3‐Carboxy‐Δ2‐isoxazoline Amino Acids and Evaluation of Their Interaction with GABA Receptors and Transporters (2006) (16)
- The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties (1993) (15)
- Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. (2007) (15)
- Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. (2007) (15)
- 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives. (1999) (15)
- Anticonvulsant Actions of Novel and Reference Adenosine Agonists (1995) (12)
- Development of 123I-labelled NNC 13-8241 as a radioligand for SPECT visualization of benzodiazepine receptor binding. (1996) (12)
- A highly selective agonist for the metabotropic glutamate receptor mGluR2 (2011) (11)
- Pentylenetetrazol-induced seizures increase [3H]L-2-amino-4-phosphonobutyrate binding in discrete regions of the rat brain (1999) (10)
- Adenosine A1 and A3 selective N‐alkoxypurines as novel cytokine modulators and neuroprotectants (1998) (9)
- New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. (2016) (9)
- Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation. (1998) (8)
- Effects of bromohomoibotenate on metabotropic glutamate receptors. (1994) (8)
- Asymmetric synthesis of enantiomerically pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A potent and selective ligand at group II metabotropic glutamate receptors (1996) (8)
- Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139. (2021) (7)
- The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function. (1995) (7)
- Phenylglycines can Evoke Quisqualate‐primed Depolarizations in Rat Cingulate Cortex: An Effect Associated with [3H]DL‐AP4 Uptake (1996) (7)
- 2.217 1-Aminoindan, a main metabolite of rasagiline, enhances dopamine release and provides symptomatic benefit in an animal model of Parkinson's disease (2007) (6)
- Synthesis and biological evaluation of 6-carboxy-3,4-methanoprolines, new rigid glutamate analogs. (1995) (5)
- Synthesis and Biology of the Rigidified Glutamate Analogue, trans-2- Carboxyazetidine-3-acetic Acid (t-CAA). (2010) (4)
- Characterization of [3H]‐N‐[R‐(2‐ Benzothiazolyl)thio‐2‐propyl]‐2‐chloroadenosine ([3H]‐NNC 21‐0136) binding to rat brain: Profile of a novel selective agonist for adenosine A1 receptors (1997) (3)
- Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites (2016) (3)
- Nociceptin receptor agonists (2001) (2)
- Modulators of the GABAA receptor: Novel therapeutic prospects (2001) (2)
- Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6‐OHDA lesioned rats (1998) (2)
- Determination of the intrinsic functional muscarinic activity of xanomeline (1999) (1)
- Synthesis and Preliminary Biological Evaluation of (2S,1′R,2′S)‐ and (2S,1′S,2′R)‐2‐(2′‐Phosphonocyclopropyl)glycines, Two Novel Conformationally Constrained L‐AP4 Analogues. (2006) (0)
- Molecular pharmacology aspects of metabotropic glutamate receptors : implications in epilepsy (1999) (0)
- Pharmacological studies on agonists and antagonists of metabotropic glutamate receptors (1995) (0)
- Novel heterocyclic compounds as mGlu5 antagonists: WO2009015897 (2010) (0)
- New potent muscarinic 1,2,5-thiadiazole-azacycles and dimers hereof (1999) (0)
- Pharmacological studies on new agonists and antagonists of mGluRs (1996) (0)
- tolerance by cholinergic agonism in high fat-fed mice Increased insulin secretion and normalization of glucose (2016) (0)
- Pharmacology of L-AP4 — sensitive mGluRs (1996) (0)
- Asymmetric Synthesis of Enantiomerically Pure (2S,1′S,2′S,3′R)- Phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors. (1997) (0)
- Muscarinic agonists with antipsychotic-like activity. Structure activity-relationships of 1,2,5-thiadiazole analogues with functioally dopamine antagonist activity (1999) (0)
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