Christina Curtis
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Professor of Medicine and Genetics, Stanford University School of Medicine
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Why Is Christina Curtis Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christina Curtis is an American scientist who is a Professor of Medicine, Genetics and Biomedical Data Science and an Endowed Scholar at Stanford University where her research investigates the evolution of tumors. She is director of Artificial Intelligence and Cancer Genomics at Stanford University School of Medicine and is on the board of directors of the American Association for Cancer Research.
Christina Curtis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups (2012) (4591)
- Comprehensive molecular characterization of gastric adenocarcinoma (2014) (4496)
- The clonal and mutational evolution spectrum of primary triple-negative breast cancers (2012) (1807)
- Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics (2013) (1443)
- A Big Bang model of human colorectal tumor growth (2015) (824)
- Clonal replacement of tumor-specific T cells following PD-1 blockade (2019) (688)
- The chromatin accessibility landscape of primary human cancers (2018) (646)
- The shaping and functional consequences of the microRNA landscape in breast cancer (2013) (390)
- Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling (2012) (367)
- Quantitative evidence for early metastatic seeding in colorectal cancer (2019) (267)
- Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. (2017) (248)
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) (234)
- Quantification of subclonal selection in cancer from bulk sequencing data (2016) (203)
- Dynamics of breast cancer relapse reveal late recurring ER-positive genomic subgroups (2019) (192)
- Genome-driven integrated classification of breast cancer validated in over 7,500 samples (2014) (174)
- Improving Breast Cancer Survival Analysis through Competition-Based Multidimensional Modeling (2013) (148)
- CRISPR screens in cancer spheroids identify 3D growth specific vulnerabilities (2020) (145)
- ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium (2011) (132)
- Between-Region Genetic Divergence Reflects the Mode and Tempo of Tumor Evolution (2017) (129)
- Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes (2007) (120)
- Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases (2020) (118)
- A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. (2017) (117)
- Systematic Analysis of Challenge-Driven Improvements in Molecular Prognostic Models for Breast Cancer (2013) (113)
- The pitfalls of platform comparison: DNA copy number array technologies assessed (2009) (107)
- Swift: primary data analysis for the Illumina Solexa sequencing platform (2009) (103)
- An expanded universe of cancer targets (2021) (86)
- Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice (2018) (78)
- Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. (2013) (76)
- Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy (2009) (60)
- Bayesian Network Inference Modeling Identifies TRIB1 as a Novel Regulator of Cell-Cycle Progression and Survival in Cancer Cells. (2017) (59)
- Characterizing the ecological and evolutionary dynamics of cancer (2020) (59)
- Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer (2018) (58)
- The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31 (2014) (54)
- Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis (2021) (53)
- Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone. (2015) (52)
- A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila (2009) (49)
- The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D (2021) (49)
- The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor (2020) (44)
- Harnessing Tumor Evolution to Circumvent Resistance. (2018) (44)
- A population genetics perspective on the determinants of intra-tumor heterogeneity. (2017) (43)
- Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases (2019) (41)
- Explaining differences in saturation levels for Affymetrix GeneChip® arrays (2007) (41)
- Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism (2020) (41)
- A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer (2014) (38)
- Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy (2019) (37)
- Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing (2020) (36)
- Big Bang Tumor Growth and Clonal Evolution. (2018) (35)
- A Sparse Regulatory Network of Copy-Number Driven Gene Expression Reveals Putative Breast Cancer Oncogenes (2012) (34)
- A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. (2021) (34)
- Breast cancer cell-free DNA (cfDNA) profiles reflect underlying tumor biology: The Circulating Cell-Free Genome Atlas (CCGA) study. (2018) (33)
- Many private mutations originate from the first few divisions of a human colorectal adenoma (2015) (32)
- Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020) (32)
- Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer (2021) (32)
- Cell of Origin Influences Pancreatic Cancer Subtype. (2021) (31)
- Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07) (2020) (29)
- Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response (2020) (28)
- Looking backward in time to define the chronology of metastasis (2020) (26)
- Assessment of ERBB2/HER2 Status in HER2-Equivocal Breast Cancers by FISH and 2013/2014 ASCO-CAP Guidelines (2018) (23)
- Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers (2012) (23)
- MITI minimum information guidelines for highly multiplexed tissue images (2021) (22)
- Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer (2019) (21)
- The importance of platform annotation in interpreting microarray data. (2010) (18)
- Precise inference of copy number alterations in tumor samples from SNP arrays (2013) (16)
- Genomic profiling of breast cancers (2015) (16)
- Abstract 5016: The human sub-ependymal zone harbors glioblastoma precursors and represents a distinct therapeutic target. (2013) (16)
- Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel. (2009) (14)
- The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer (2021) (13)
- Organoids reveal cancer dynamics (2018) (12)
- Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer (2022) (12)
- Erratum to: Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes (2016) (12)
- A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer (2021) (12)
- ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung (2022) (11)
- Molecular Heterogeneity and Evolution in Breast Cancer (2021) (10)
- Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer (2016) (10)
- The Mettl3 epitranscriptomic writer amplifies p53 stress responses (2021) (9)
- Most cancers carry a substantial deleterious load due to Hill-Robertson interference (2019) (9)
- Calling Sample Mix-Ups in Cancer Population Studies (2012) (6)
- Inferring Tumor Phylogenies from Multi-region Sequencing. (2016) (6)
- 13 DNA Methylation Arrays: Methods and Analysis (2008) (4)
- DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts (2021) (4)
- Quantifying mutations in healthy blood (2020) (4)
- A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes (2010) (4)
- Penalized regression elucidates aberration hotspots mediating subtype-specific transcriptional responses in breast cancer (2011) (4)
- Androgen receptor agonists as breast cancer therapeutics (2021) (4)
- Abstract LB-343: Development of plasma cell-free DNA (cfDNA) assays for early cancer detection: first insights from the Circulating Cell-Free Genome Atlas Study (CCGA) (2018) (4)
- The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31 (2014) (3)
- Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts. (2022) (3)
- Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids (2022) (3)
- Higher peripheral lymphocyte count to predict survival in triple-negative breast cancer (TNBC). (2016) (3)
- Abstract 2688: Pan-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases (2020) (2)
- A role for chromatin regulatory dynamics in breast cancer evolution (2018) (2)
- Publisher Correction: Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy (2019) (1)
- Early mutation bursts in colorectal tumors (2017) (1)
- Transcriptome and genome evolution during HER2-amplified breast neoplasia (2020) (1)
- Yinyin Yuan Complements Genomic Profiling Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors (2012) (1)
- COMPLEX EVOLUTIONARY DYNAMICS GENERATES GENETIC DIVERSITY AND INTRA-TUMOR HETEROGENEITY IN INDIVIDUAL PATIENTS WITH GLIOBLASTOMA (2014) (1)
- Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy (2019) (1)
- Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer (2022) (1)
- Tumor Molecular Profiling Aids in Determining Tissue of Origin and Therapy for Metastatic Adenocarcinoma in a Patient With Multiple Primary Malignancies. (2018) (1)
- Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data (2018) (1)
- Deterministic evolution and stringent selection during pre-neoplasia (2023) (1)
- OMICS AND PROGNSTIC MARKERS (2013) (1)
- Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers (2012) (1)
- Multi-omic Analysis of Familial Adenomatous Polyposis Reveals Molecular Pathways and Polyclonal Spreading Associated with Early Tumorigenesis (2021) (1)
- A tumor "personality" test to guide therapeutic decision making. (2021) (1)
- Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer (2017) (1)
- Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers (2020) (1)
- Correcting for probe-design in the analysis of gene-expression microarrays (2007) (1)
- Genome-driven integrated classification of breast cancer validated in over 7,500 samples (2014) (1)
- Cell division history encodes directional information of fate transitions (2022) (1)
- Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity (2023) (0)
- Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen (2019) (0)
- Abstract PD5-08: The human tumor atlas network (HTAN) breast pre cancer atlas: A multi-omic integrative analysis of ductal carcinoma in situ (DCIS) and correlation with clinical outcomes (2021) (0)
- The Big Bang Theory of Tumor Evolution (2016) (0)
- Structural Insights into Binding Specificity , Efficacy and Bias of Salmeterol , a Long-Acting β 2 Adrenergic Receptor Agonist (2019) (0)
- Cancers adapt to their mutational load by buffering protein misfolding stress (2023) (0)
- AGBT meeting report (2018) (0)
- Abstract P4-07-01: Tumor expression and microenvironment in HER2-positive breast cancer before and on HER2-targeted therapy: Analysis of microarray expression data from the TRIO-US B07 trial (2020) (0)
- Integrating Quantitative Approaches in Cancer Research and Oncology (2021) (0)
- The Human Tumor Atlas Network (HTAN) Breast Precancer Atlas: A Multi-Omic Integrative Analysis of Ductal Carcinoma in situ With Clinical Outcomes (2021) (0)
- Abstract P3-06-01: Clonal evolution and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy (2019) (0)
- P 2 X 5 Purinergic Receptor : A Novel Regulator of Human Cardiac Progenitor Cell Proliferation and Survival (2019) (0)
- Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups (2019) (0)
- Abstract SY36-01: Exploiting intra-tumor heterogeneity through agent-based models of tumor growth to infer properties of human malignancies. (2013) (0)
- Author response: Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing (2020) (0)
- Abstract 2105: Cell-free DNA fragments inform epigenomic mechanisms for early detection of breast cancer (2021) (0)
- Looking backward in time to define the chronology of metastasis (2020) (0)
- Abstract 123: A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation (2021) (0)
- Abstract GS3-06: Dynamics of breast cancer relapse reveal molecularly defined late recurring ER-positive subgroups: Results from the METABRIC study (2019) (0)
- Publisher Correction: Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy (2019) (0)
- Abstract B020: A copy number and expression based classifier for breast cancer tumors (2013) (0)
- Abstract IA026: Charting genotype to phenotype maps of tumorigenesis (2022) (0)
- Sa134 A CRISPR/CAS9-ENGINEERED ARID1A-DEFICIENT HUMAN GASTRIC CANCER ORGANOID MODEL REVEALS ESSENTIAL AND NON-ESSENTIAL MODES OF ONCOGENIC TRANSFORMATION (2021) (0)
- Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data (2018) (0)
- Integrated genomic characterization of oesophageal carcinoma (2017) (0)
- High-throughput analysis of methylation patterns to track cell divisions (2008) (0)
- Global loss of fine-scale chromatin architecture and rebalancing of gene expression during early colorectal cancer development (2022) (0)
- A role for chromatin regulatory dynamics in breast cancer evolution (2018) (0)
- A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids (2022) (0)
- O11TRANSCRIPTIONAL PROFILING OF DISTINCT COMPARTMENTS IN HUMAN GLIOBLASTOMA REVEALS KEY DYSREGULATED PATHWAYS (2014) (0)
- Organoids reveal cancer dynamics (2018) (0)
- Abstract ED7-4: Beyond the lab: Clinical implications (2023) (0)
- Transcriptome and genome evolution during HER2-amplified breast neoplasia (2021) (0)
- Patient perspectives on window of opportunity clinical trials in early-stage breast cancer (2022) (0)
- AGBT meeting report (2018) (0)
- Abstract 2108: Chromatin state as a mechanism of anthracycline response in breast cancer (2019) (0)
- Abstract 5713: Reprogramming of serine metabolism during breast cancer progression (2020) (0)
- Explaining Dierences in Saturation Levels for (2006) (0)
- Abstract GS4-07: The Breast PreCancer Atlas DCIS genomic signatures define biology and correlate with clinical outcomes: An analysis of TBCRC 038 and RAHBT cohorts (2022) (0)
- Quantification of subclonal selection in cancer from bulk 1 sequencing data 2 3 (2018) (0)
- Abstract IA04: Understanding tumor heterogeneity in glioblastoma (2015) (0)
- Pan-cancer organoid validation of tumor outlier chromosomal amplification events (2021) (0)
- Quantitative evidence for early metastatic seeding in colorectal cancer (2019) (0)
- Abstract I15: Deciphering the origins of PDAC development (2019) (0)
- Clonal replacement of tumor-specific T cells following PD-1 blockade (2019) (0)
- Understanding patient perspectives on window of opportunity clinical trials. (2020) (0)
- Abstract PD3-11:HER2/ERBB2status in “HER2equivocal” breast cancers by FISH and ASCO-CAP guidelines: False-positives due to heterozygous deletions of alternative control loci (2019) (0)
- Erratum to: Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes (2016) (0)
- O4.05GENETIC DIVERSITY AND INTRA-TUMOR HETEROGENEITY IN HUMAN GLIOBLASTOMA (2014) (0)
- Abstract 3497: The polyclonal path to malignant transformation in familial adenomatous polyposis (2023) (0)
- Translating Basic Cancer Discoveries to the Clinic. (2020) (0)
- Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice (2018) (0)
- Profiles and Cancer Stem Cell Organization Single-Molecule Genomic Data Delineate Patient-Specific Tumor (2012) (0)
- Abstract A15: Elucidating the role of p53 in the cellular origins of pancreatic cancer development (2019) (0)
- Quantification of subclonal selection in cancer from bulk sequencing data (2018) (0)
- Dynamics of relapse in breast cancer (2016) (0)
- CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities (2020) (0)
- "Fateful" encounter: Lineage tracing meets phylogeny to unravel mysteries of cancer progression. (2022) (0)
- Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities (2023) (0)
- 825 Towards a systems-level view of breast cancer through the joint analysis of multi-dimensional data (2010) (0)
- Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer (2016) (0)
- Abstract P2-06-01: Characterisation of C11orf67, an oncogenic driver in a new subtype of aggressive endocrine receptor positive breast cancer (2016) (0)
- Abstract 5954: Germline epitopes modulate immune surveillance informing breast cancer subtypes (2023) (0)
- The Human Tumor Atlas Network (HTAN) Breast PreCancer Atlas: A multi-omic integrative analysis of ductal carcinoma in situ with clinical outcomes (2021) (0)
- Identification and validation of a novel drug target in an organoid model of esophageal cancer. (2018) (0)
- Abstract IA14: Deconstructing the origins of PDAC development (2020) (0)
- Integrated Systems and Technologies Single-Molecule Genomic Data Delineate Patient-Speci fi c Tumor Pro fi les and Cancer Stem Cell Organization (2012) (0)
- Abstract P4-10-12: Characterizing the tumor and immune microenvironment through treatment to predict response to neoadjuvant HER2-targeted therapy using the Digital Spatial Profiler (2020) (0)
- Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer (2017) (0)
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