Christine Beeton
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Immunologist
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Christine Beetonbiology Degrees
Biology
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Immunology
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Biology
Christine Beeton's Degrees
- PhD Immunology Stanford University
- Doctorate Medicine Stanford University
Why Is Christine Beeton Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christine Beeton is an immunologist and associate professor at the Baylor College of Medicine in Houston, Texas. She works within the Department of Molecular Physiology and Biophysics. Beeton graduated from the Faculté des Sciences de Luminy within the Université de la Mediterranée in Marseille, France and later as a postdoctoral fellow from the University of California. Her professional interests and areas of expertise include autoimmune diseases , drug development, ions and ion channels in disease, and targeted therapies.
Christine Beeton's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases (2006) (494)
- K+ channels as targets for specific immunomodulation. (2004) (444)
- The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. (2003) (409)
- Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis (2001) (316)
- Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation (2018) (273)
- Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases (2005) (230)
- Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. (2008) (193)
- Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. (2012) (190)
- The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. (2005) (185)
- Selective Blocking of Voltage-Gated K+ Channels Improves Experimental Autoimmune Encephalomyelitis and Inhibits T Cell Activation1 (2001) (178)
- Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis (2011) (150)
- Detection of Functional Matrix Metalloproteinases by Zymography (2010) (137)
- Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. (2004) (126)
- Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes (2009) (122)
- Potassium channels as therapeutic targets for autoimmune disorders. (2003) (118)
- Potassium Channels, Memory T Cells, and Multiple Sclerosis (2005) (109)
- AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9 (2020) (107)
- Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease (2012) (104)
- Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases. (2011) (90)
- A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes* (2003) (88)
- Vm24, a Natural Immunosuppressive Peptide, Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells (2012) (83)
- Kv1.3 channel‐blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases (2014) (69)
- A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases (2014) (67)
- Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy. (2014) (61)
- Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma* (2014) (60)
- A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation (2013) (55)
- Drawing blood from rats through the saphenous vein and by cardiac puncture. (2007) (54)
- Evidence for Domain-specific Recognition of SK and Kv Channels by MTX and HsTx1 Scorpion Toxins* (2004) (54)
- The D-Diastereomer of ShK Toxin Selectively Blocks Voltage-gated K+ Channels and Inhibits T Lymphocyte Proliferation* (2008) (53)
- Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK (2015) (48)
- Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. (2017) (46)
- Ion channels and anti-cancer immunity (2014) (44)
- Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function (2015) (41)
- Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes (2013) (40)
- KCa1.1 Potassium Channels Regulate Key Proinflammatory and Invasive Properties of Fibroblast-like Synoviocytes in Rheumatoid Arthritis* (2011) (39)
- A C‐terminally amidated analogue of ShK is a potent and selective blocker of the voltage‐gated potassium channel Kv1.3 (2012) (38)
- Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response (2019) (35)
- Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis. (2007) (31)
- Differences in ion channel phenotype and function between humans and animal models. (2018) (30)
- Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation (2016) (30)
- The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. (2015) (28)
- Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for Production of KV1.3 Channel Blockers (2012) (25)
- Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry (2010) (23)
- KCa1.1 Inhibition Attenuates Fibroblast‐like Synoviocyte Invasiveness and Ameliorates Disease in Rat Models of Rheumatoid Arthritis (2015) (23)
- N‐terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage‐gated potassium channel Kv1.3 (2015) (22)
- Detection of Matrix Metalloproteinases by Zymography. (2017) (22)
- Isolation of mononuclear cells from the central nervous system of rats with EAE. (2007) (20)
- The impact of the fourth disulfide bridge in scorpion toxins of the α‐KTx6 subfamily (2005) (20)
- Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria. (2012) (18)
- Vm 24 , a Natural Immunosuppressive Peptide , Potently and Selectively Blocks Kv 1 . 3 Potassium Channels of Human T Cells (2012) (18)
- Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis (2018) (17)
- Induction and monitoring of active delayed type hypersensitivity (DTH) in rats. (2007) (17)
- KCa1.1 channels regulate β1‐integrin function and cell adhesion in rheumatoid arthritis fibroblast‐like synoviocytes (2017) (17)
- Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats (2017) (16)
- Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts (2016) (16)
- Preparing T cell growth factor from rat splenocytes. (2007) (15)
- KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis (2019) (14)
- Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. (2020) (14)
- Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease. (2014) (13)
- Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes (2016) (13)
- Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats (2007) (13)
- Kv1.3 Potassium Channel: Physiology, Pharmacology and Therapeutic Indications (2006) (12)
- Targets and Therapeutic Properties (2013) (12)
- Changes in Gene Expression and Metabolism in the Testes of the Rat following Spinal Cord Injury. (2017) (11)
- CHAPTER 10:Case Study 2: Transforming a Toxin into a Therapeutic: the Sea Anemone Potassium Channel Blocker ShK Toxin for Treatment of Autoimmune Diseases (2015) (9)
- Targets and Therapeutic Properties of Venom Peptides (2006) (9)
- Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin (2015) (9)
- Enrichment of NK cells from human blood with the RosetteSep kit from StemCell technologies. (2007) (9)
- Myelin basic protein-reactive T cells induce conduction failure in vivo but not in vitro (2003) (8)
- Erratum: The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS (Journal of Clinical Investigation (2003) 111 (1703-1713)) (2003) (8)
- [Ion channels and demyelination: basis of a treatment of experimental autoimmune encephalomyelitis (EAE) by potassium channel blockers]. (2004) (5)
- KCa1.1 channels as therapeutic targets for rheumatoid arthritis (2017) (5)
- Imaging effector memory T cells in the ear after induction of adoptive DTH. (2008) (4)
- A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis (2022) (3)
- Vm24, a natural immunosuppressant peptide potently and selectively blocks Kv1.3 potassium channels of human T cells (2012) (3)
- Antioxidant Carbon Nanoparticles Inhibit Fibroblast-Like Synoviocyte Invasiveness and Reduce Disease Severity in a Rat Model of Rheumatoid Arthritis (2020) (3)
- Durable pharmacological responses from the peptide drug ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease (51.5) (2012) (2)
- Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes (2016) (2)
- Characterization of a novel MR‐detectable nanoantioxidant that mitigates the recall immune response (2016) (2)
- 37. A Sea Anemone Toxin to Treat Autoimmune Diseases: ShK and its Analogs (2012) (1)
- Targeting potassium channels in rheumatoid arthritis (2018) (1)
- Blocking KCa1.1 Channels Inhibits the Pathogenic Features of Fibroblast-Like Synoviocytes and Treats Rat Models of Rheumatoid Arthritis (2014) (1)
- Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts (2022) (1)
- The role of SOD‐2 in a mouse model of multiple sclerosis (2012) (1)
- 38. Development of the Sea Anemone Toxin ShK-186 for the Treatment of Autoimmune Diseases: PK and ADME Perspectives (2012) (1)
- The Functional Swtich in Potassium Channels in Myotonic Dystrophy Type 1 Impairs Proliferation, Migration and Fusion During Myogenesis (2014) (1)
- Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function (2015) (0)
- 15 INHIBITING EFFECTOR MEMORY T CELLS WITH SHK(L5), A NOVEL PEPTIDE BLOCKER OF THE KV1.3 POTASSIUM CHANNEL. (2007) (0)
- Running head : Targeting KCa 1 . 1 channels in animal models of RA Title : KCa 1 . 1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates rat models of rheumatoid arthritis (2014) (0)
- Amendment history : Erratum ( July 2003 ) The voltage-gated Kv 1 . 3 K + channel in effector memory T cells as new target for MS (2018) (0)
- Novel therapeutics for autoimmune diseases from food (2019) (0)
- T.30. Targeting Fibroblast-like Synoviocyte Potassium Channels for the Treatment of Rheumatoid Arthritis (2009) (0)
- Kv1.3-Blocking Peptides from Parasitic Worms Exhibit Immunomodulatory Function (2014) (0)
- Title: Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis (2018) (0)
- Kv1.3 Selective Peptides Based upon N-Terminal Extension and Internal Substitutions of ShK Toxin (2015) (0)
- Su.36. Gad-Reactive, Effector Memory Cd4+ T-Cells Cultured from Type 1 Diabetic Patients Express Increased Levels of the Voltage-Gated Potassium Channel Kv1.3: a Potential Therapeutic Target (2006) (0)
- sustain muscle function (2015) (0)
- Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats (2017) (0)
- Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis (2021) (0)
- KCa1.1 (BK) Channels on Fibroblast-Like Synoviocytes: A Novel Therapeutic Target for Rheumatoid Arthritis (2015) (0)
- Identification of genetic elements in metabolism by high-throughput mouse phenotyping (2018) (0)
- ShK toxin analogues and their use in selectively inhibiting Kv1.3 potassium channels (2005) (0)
- Preferential internalization of antioxidant carbon nanoparticles by T lymphocytes to treat autoimmune diseases (2016) (0)
- Structure of Lymphocyte Potassium Channel K v1.3 and Modulation by Cell-Penetrating Immunomodulatory Plant Defensin (2019) (0)
- Targeting Potassium Channels on Fibroblast‐like Synoviocytes for the Treatment of Rheumatoid Arthritis (2011) (0)
- Targeting Potassium Channels On Fibroblast‐like Synoviocytes For The Treatment Of Pristane Induced Arthritis In A Rat Model (2012) (0)
- Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver (2023) (0)
- Potassium channels on natural killer cells in the presence of breast carcinoma cells (2012) (0)
- Th2 lymphocyte potassium channels in asthma (2011) (0)
- Targeting natural killer cell potassium channels for selective immunomodulation (134.14) (2009) (0)
- Live imaging of effector memory T cells at a site of inflammation –a Kv1.3 blocker suppresses T cell motility (2007) (0)
- Expression of cystic fibrosis transmembrane regulator (CFTR) in human bone cells (2008) (0)
- Discovery on Target 2007--CHI's Fifth Annual Conference. Ion channels. (2007) (0)
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