Christine Guthrie | Academic Influence

Christine Guthrie's AcademicInfluence.com Rankings

Christine Guthrie

Biology

#2207

World Rank

#3533

Historical Rank

#995

USA Rank

Genetics

#403

World Rank

#469

Historical Rank

#172

USA Rank

Biochemistry

#708

World Rank

#808

Historical Rank

#214

USA Rank

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Biology

Christine Guthrie's Degrees

PhD Biochemistry Stanford University
Bachelors Biology University of California, Berkeley

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Why Is Christine Guthrie Influential?

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According to Wikipedia, Christine Guthrie was an American yeast geneticist and American Cancer Society Research Professor of Genetics at University of California San Francisco. She showed that yeast have small nuclear RNAs involved in splicing pre-messenger RNA into messenger RNA in eukaryotic cells. Guthrie cloned and sequenced the genes for yeast snRNA and established the role of base pairing between the snRNAs and their target sequences at each step in the removal of an intron. She also identified proteins that formed part of the spliceosome complex with the snRNAs. Elected to the National Academy of Sciences in 1993, Guthrie edited Guide to Yeast Genetics and Molecular Biology, an influential methods series for many years.

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Christine Guthrie's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guide to yeast genetics and molecular biology (1993) (1527)
Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor (1997) (1169)
Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things (1998) (1149)
Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA (1987) (441)
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome (1992) (424)
Methods in enzymology vol 194 guide to yeast genetics and molecular biology (1991) (418)
Messenger RNA splicing in yeast: clues to why the spliceosome is a ribonucleoprotein. (1991) (375)
Dynamic RNA-RNA interactions in the spliceosome. (1994) (350)
Spliceosomal RNA U6 is remarkably conserved from yeast to mammals (1988) (346)
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p. (1999) (331)
RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2 (1998) (308)
PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome (1991) (297)
5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. (1988) (284)
Mutations in U6 snRNA that alter splice site specificity: implications for the active site. (1993) (270)
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. (2008) (266)
Rapid, transcript-specific changes in splicing in response to environmental stress. (2007) (233)
Spliceosomal snRNAs. (1988) (229)
The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim. (2005) (210)
Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components (2007) (206)
Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. (2001) (204)
Hierarchical modularity and the evolution of genetic interactomes across species. (2012) (198)
The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. (2004) (196)
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. (1992) (190)
A novel role for a U5 snRNP protein in 3' splice site selection. (1995) (186)
Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome. (1986) (185)
The question remains: Is the spliceosome a ribozyme? (2000) (183)
Structure and function of E. coli ribosomes. 8. Cold-sensitive mutants defective in ribosome assembly. (1969) (177)
A mechanism to enhance mRNA splicing fidelity: The RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates (1993) (175)
Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1. (1993) (170)
The second catalytic step of pre-mRNA splicing. (1995) (167)
Multiple roles for U6 snRNA in the splicing pathway. (1990) (166)
Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation. (2001) (156)
Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. (1996) (154)
A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles. (1998) (153)
A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing (1990) (153)
Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs. (1991) (145)
An essential yeast snRNA with a U5-like domain is required for splicing in vivo (1987) (137)
ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C-terminus of Prp8 (2008) (132)
An essential splicing factor, SLU7, mediates 3' splice site choice in yeast. (1992) (131)
Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position. (1990) (129)
A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. (1991) (128)
Conservation in budding yeast of a kinase specific for SR splicing factors. (1999) (127)
From Structure to Systems: High-Resolution, Quantitative Genetic Analysis of RNA Polymerase II (2013) (126)
Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. (1999) (124)
Reciprocal intronic and exonic histone modification regions in humans (2010) (121)
Alternative 3'-end processing of U5 snRNA by RNase III. (1997) (119)
A U-rich tract enhances usage of an alternative 3′ splice site in yeast (1991) (112)
A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. (2008) (111)
Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. (1995) (109)
Initiation of Protein Synthesis : a Critical Test of the 30S Subunit Model (1968) (108)
Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome. (1994) (106)
The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. (2005) (105)
Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles. (2005) (105)
Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing (1992) (104)
Conformational dynamics of single pre-mRNA molecules during in vitro splicing (2010) (102)
Yeast contains small nuclear RNAs encoded by single copy genes (1983) (101)
A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation (1985) (101)
The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro (1998) (100)
Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2 (2009) (98)
A precursor to a minor species of yeast tRNASer contains an intervening sequence (1979) (97)
Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. (1996) (95)
Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs. (2004) (93)
A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport (2000) (93)
Saccharomyces cerevisiae has a U1-like small nuclear RNA with unexpected properties. (1987) (90)
Beat the clock: paradigms for NTPases in the maintenance of biological fidelity. (1993) (89)
Spliceosomal snRNAs Mg2+-Dependent Chemistry at the Catalytic Core? (2002) (89)
A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. (1987) (89)
Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides (1988) (88)
Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast. (1995) (86)
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. (2005) (85)
Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity. (1986) (83)
A conserved Lsm-interaction motif in Prp24 required for efficient U4/U6 di-snRNP formation. (2002) (82)
Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo. (1990) (82)
Unexpected flexibility in an evolutionarily conserved protein‐RNA interaction: genetic analysis of the Sm binding site. (1990) (81)
The essential yeast RNA binding protein Np13p is methylated. (1996) (80)
Genetic Analysis Reveals a Role for the C Terminus of the Saccharomyces cerevisiae GTPase Snu114 During Spliceosome Activation (2005) (79)
Genetic analysis of small nuclear RNAs in Saccharomyces cerevisiae: viable sextuple mutant (1988) (77)
Essential Yeast Protein with Unexpected Similarity to Subunits of Mammalian Cleavage and Polyadenylation Specificity Factor (CPSF) (1996) (75)
Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing (2013) (73)
An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA (1987) (72)
Splicing a spliceosomal RNA (1989) (71)
PRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitro. (1994) (71)
Architecture of the U5 small nuclear RNA (1994) (67)
Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans. (2007) (64)
Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs. (1995) (62)
Structure of intron-containing tRNA precursors. Analysis of solution conformation using chemical and enzymatic probes. (1984) (62)
Transcriptional pulse‐chase analysis reveals a role for a novel snRNP‐associated protein in the manufacture of spliceosomal snRNPs. (1996) (61)
A subset of yeast snRNA's contains functional binding sites for the highly conserved Sm antigen. (1987) (61)
Deletion of a yeast small nuclear RNA gene impairs growth. (1985) (58)
Organization and Expression of tRNA Genes in Saccharomyces cerevisiae (1982) (57)
The nucleotide sequence of the dimeric precursor to glutamine and leucine transfer RNAs coded by bacteriophage T4. (1975) (55)
Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast. (2011) (55)
The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing (2012) (55)
A functional requirement for modification of the wobble nucleotide in the anticodon of a T4 suppressor tRNA (1976) (55)
PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. (1998) (55)
An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport (2001) (54)
Expression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism. (2002) (54)
Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA. (2006) (51)
Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. (2006) (47)
Electrophoretic and immunological studies on ribosomal proteins of 100 Escherichia coli revertants from streptomycin dependence (1973) (47)
The initiation of protein synthesis: joining of the 50S ribosomal subunit to the initiation complex. (1967) (44)
A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome (1992) (44)
Alternative 3′ Pre-mRNA Processing in Saccharomyces cerevisiae Is Modulated by Nab4/Hrp1 In Vivo (2006) (43)
Guide to yeast genetics : functional genomics, proteomics, and other systems analysis (2010) (39)
A U4-like small nuclear RNA is dispensable in yeast (1983) (39)
SR protein kinases promote splicing of nonconsensus introns (2015) (37)
Colony PCR. (2013) (37)
Evolutionarily Conserved Polyadenosine RNA Binding Protein Nab2 Cooperates with Splicing Machinery To Regulate the Fate of Pre-mRNA (2016) (36)
Diverse Forms of RPS9 Splicing Are Part of an Evolving Autoregulatory Circuit (2012) (36)
Evolution of Yeast Noncoding RNAs Reveals an Alternative Mechanism for Widespread Intron Loss (2010) (36)
Human U2 snRNA can function in pre-mRNA splicing in yeast (1990) (36)
Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. (1994) (34)
Finding functions for small nuclear RNAs in yeast (1986) (34)
The assembly of ribosomes (1969) (33)
Adventures in time and space (2014) (32)
Regulation of the Dbp5 ATPase cycle in mRNP remodeling at the nuclear pore: a lively new paradigm for DEAD-box proteins. (2011) (29)
More than half of yeast U1 snRNA is dispensable for growth. (1991) (28)
Yeast ochre suppressor SUQ5-ol is an altered tRNA Ser UCA (1981) (28)
Genetic Interaction Mapping Reveals a Role for the SWI/SNF Nucleosome Remodeler in Spliceosome Activation in Fission Yeast (2015) (27)
Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing. (2001) (27)
Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts. (2007) (26)
The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing (2014) (25)
Studies on the assembly of ribosomes in vivo. (1969) (25)
Yeast tRNA precursor mutated at a splice junction is correctly processed in vivo. (1981) (25)
Activation of a cryptic TACTAAC box in the Saccharomyces cerevisiae actin intron (1986) (23)
Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency (2017) (22)
Recessive lethality of yeast strains carrying the SUP61 suppressor results from loss of a transfer RNA with a unique decoding function. (1982) (22)
Small nuclear RNAs from budding yeasts: phylogenetic comparisons reveal extensive size variation. (1989) (22)
H2B ubiquitylation modulates spliceosome assembly and function in budding yeast (2014) (22)
The histone variant H2A.Z promotes splicing of weak introns (2017) (21)
Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough (2015) (21)
Autoregulation of Npl3, a Yeast SR Protein, Requires a Novel Downstream Region and Serine Phosphorylation (2008) (21)
Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing (2016) (20)
Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast. (2010) (19)
An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8 (2014) (18)
Human and human-yeast chimeric U6 snRNA genes identify structural elements required for expression in yeast. (1992) (17)
Genetics and biochemistry remain essential in the structural era of the spliceosome. (2017) (13)
Modifications target spliceosome dynamics (2008) (13)
Nucleus and gene expression: Coordinated nuclear events regulate mRNA synthesis, processing, export and turnover (2005) (13)
Biochemical Characterization of RNase P: A tRNA Processing Activity with Protein and RNA Components (1980) (13)
Catalytic RNA and RNA Splicing (1989) (13)
From the Ribosome to the Spliceosome and Back Again (2009) (13)
Asymmetric maturation of a dimeric transfer RNA precursor. (1980) (11)
Prp8 positioning of U5 snRNA is linked to 5′ splice site recognition (2018) (11)
The nucleotide sequence of threonine transfer RNA coded by bacteriophage T4. (1978) (11)
Genetic Analysis of Yeast snRNAs (1988) (10)
S1 nuclease as a probe for the conformation of a dimeric tRNA precursor. (1979) (10)
Prp8 impacts cryptic but not alternative splicing frequency (2019) (10)
Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity*♦ (2016) (10)
Genetic interaction analysis of point mutations enables interrogation of gene function at a residue‐level resolution (2014) (8)
Chemical transformation of yeast. (2013) (8)
The spliceosome is a dynamic ribonucleoprotein machine. (1994) (6)
Getting to the gate: crystallization of a Sac3(CID):Sus1:Cdc31 complex. (2009) (5)
Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant (2019) (4)
Accurate RNA Siting and Splicing Gets Help from a DEK-Hand (2006) (3)
Mechanical Devices of the Spliceosome: Review Motors, Clocks, Springs, and Things (1998) (3)
Folding Up a Transfer RNA Molecule is not Simple (1980) (3)
Identification of the Novel Nup188-brr7 Allele in a Screen for Cold-Sensitive mRNA Export Mutants in Saccharomyces cerevisiae (2018) (3)
Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope (2018) (2)
SnapShot: Formation of mRNPs (2009) (2)
Greetings from the RNA world. RNA Processing sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, May 16-20, 1990. (1990) (2)
end processing of U 5 snRNA by RNase ? III ′ Alternative 3 (1997) (2)
Yeast-gene replacement using PCR products. (2013) (1)
Small nuclear RNAs from budding yeasts: phylogenetic comparisons reveal extensive size variation**Presented at the Albany Conference on ‘RNA: Catalysis, Splicing, Evolution’, Rensselaerville, NY (U.S.A.) 22-25 September, 1988. (1989) (1)
Processing of Spacer tRNAs from rRNA Transcripts of Escherichia coli (1980) (1)
A new communication hub in the RNA world (2016) (1)
Characterization of Brr2 Helicase Activity on the U4/U6 snRNAs (2014) (0)
Genetic dissection of the U4/U6/U5 snRNP “cycle’ in yeast (2004) (0)
Structural Studies of the Yeast Prp8-Snu114 Complex (2014) (0)
The yeast of u2 small nuclear rna small nuclear r20 has two functionally important domains (1988) (0)
WIEN : Wordwise Inference and Entailment Now Or : How We Taught Machines to Recognize Natural Language Inference (2015) (0)
Brr2 is a splicing fidelity factor (2018) (0)
Yeast snRNPs (2004) (0)
Investigation of Functionally Critical Residues in the Pseudo‐ Helicase Domain of Brr2 (2013) (0)
Genetic analysis of small nuclear rna species and rna processing in yeast saccharomyces cerevisiae (1985) (0)
Recent Insights into the Regulation of mRNA Splicing (2009) (0)
Single Molecule FRET Characterization of Pre-mRNA Splicing: Substrate Dynamics during Recognition and Catalysis (2012) (0)
Crystal structure of an essential yeast splicing factor (2014) (0)
RNA: Reviewers for Volume 21, 2015. (2015) (0)
Abstracts of papers presented at the 1988 Meeting on RNA Processing, May 11-May 15, 1988 (1988) (0)
pre-mRNA splicing sequences and U6 snRNA during the second catalytic step of Genetic interactions between the 5' and 3' splice site consensus (2001) (0)
Extensive negative genetic interactions with npl3 Δ connect NPL3 to chromatin biology. (2012) (0)
The Evolutionarily-conserved Polyadenosine RNA Binding Protein , Nab 2 , 1 Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA 2 3 4 (2016) (0)
Abstracts of papers presented at the 1987 Meeting on RNA Processing, May 13-May 17, 1987 (1987) (0)
Development of an smFRET Assay to Monitor Spliceosome Activation in Budding Yeast (2014) (0)
Abstracts of papers presented at the 2001 Meeting on Eukaryotic mRNA Processing, August 22-August 26, 2001 (2001) (0)
In This Issue (2009) (0)
Present at the creation (2015) (0)

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