Christine Holt

Christine Holt's AcademicInfluence.com Rankings

Christine Holt

Biology

#2749

World Rank

#4324

Historical Rank

Neuroscience

#624

World Rank

#651

Historical Rank

biology Degrees

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Biology

Why Is Christine Holt Influential?

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According to Wikipedia, Christine Elizabeth Holt FRS, FMedSci is a British developmental neuroscientist. She has been Professor of Developmental Neuroscience, University of Cambridge, since 2003 and a Fellow of Gonville and Caius College, Cambridge University, since 1997.

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Christine Holt's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A critical window for cooperation and competition among developing retinotectal synapses (1998) (895)
Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation (2001) (768)
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function (2015) (620)
cAMP-Dependent Growth Cone Guidance by Netrin-1 (1997) (588)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions (2018) (521)
Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1 (1999) (488)
The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons (2013) (459)
Asymmetrical β-actin mRNA translation in growth cones mediates attractive turning to netrin-1 (2006) (437)
Cellular determination in the xenopus retina is independent of lineage and birth date (1988) (414)
Mechanosensing is critical for axon growth in the developing brain (2016) (406)
Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration (2005) (393)
Subcellular mRNA Localization in Animal Cells and Why It Matters (2009) (377)
Ephrin-B2 and EphB1 Mediate Retinal Axon Divergence at the Optic Chiasm (2003) (344)
Dynamic Axonal Translation in Developing and Mature Visual Circuits (2016) (327)
Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization. (2011) (316)
Cephalic expression and molecular characterization of Xenopus En-2. (1991) (313)
Retinal axons with and without their somata, growing to and arborizing in the tectum of Xenopus embryos: a time-lapse video study of single fibres in vivo. (1987) (307)
Cadherin Function Is Required for Axon Outgrowth in Retinal Ganglion Cells In Vivo (1996) (301)
Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones (2003) (293)
The transcription factor Engrailed-2 guides retinal axons (2005) (284)
Turning of Retinal Growth Cones in a Netrin-1 Gradient Mediated by the Netrin Receptor DCC (1997) (284)
Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs (2010) (280)
Signaling Mechanisms Underlying Slit2-Induced Collapse of Xenopus Retinal Growth Cones (2006) (272)
Local translation in neurons: visualization and function (2019) (266)
Navigational errors made by growth cones without filopodia in the embryonic xenopus brain (1993) (260)
Remote Control of Gene Function by Local Translation (2014) (257)
Lipofection of cDNAs in the embryonic vertebrate central nervous system (1990) (256)
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair (2012) (252)
p27Xic1, a Cdk Inhibitor, Promotes the Determination of Glial Cells in Xenopus Retina (1999) (247)
Local Translation of Extranuclear Lamin B Promotes Axon Maintenance (2012) (236)
Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons (2019) (233)
Topographic Mapping in Dorsoventral Axis of the Xenopus Retinotectal System Depends on Signaling through Ephrin-B Ligands (2002) (215)
The Neuronal Architecture of Xenopus Retinal Ganglion Cells Is Sculpted by Rho-Family GTPases In Vivo (1999) (208)
RNA translation in axons. (2004) (205)
Order in the initial retinotectal map in Xenopus: a new technique for labelling growing nerve fibres (1983) (203)
Semaphorin 3A Elicits Stage-Dependent Collapse, Turning, and Branching in Xenopus Retinal Growth Cones (2001) (193)
Ephrin-B Regulates the Ipsilateral Routing of Retinal Axons at the Optic Chiasm (2000) (193)
Local translation and directional steering in axons (2007) (193)
Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway (2002) (192)
E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN (2010) (189)
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning. (2001) (171)
FGF signaling and target recognition in the developing xenopus visual system (1995) (170)
Endocytosis-dependent desensitization and protein synthesis–dependent resensitization in retinal growth cone adaptation (2005) (169)
A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins (2009) (159)
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair (2012) (158)
Function and regulation of local axonal translation (2008) (151)
SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor (2005) (148)
Inhibition of FGF Receptor Activity in Retinal Ganglion Cell Axons Causes Errors in Target Recognition (1996) (141)
Essential role of heparan sulfates in axon navigation and targeting in the developing visual system. (1997) (139)
RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo (2017) (129)
Extracellular Engrailed Participates in the Topographic Guidance of Retinal Axons In Vivo (2009) (122)
miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones (2011) (121)
Position, guidance, and mapping in the developing visual system. (1993) (121)
Does timing of axon outgrowth influence initial retinotectal topography in Xenopus? (1984) (119)
Specific heparan sulfate structures involved in retinal axon targeting. (2002) (105)
Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordin. (2004) (105)
A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling* (2006) (104)
Sugar Codes for Axons? (2005) (104)
Molecular control of local translation in axon development and maintenance (2018) (100)
B-type Eph receptors and ephrins induce growth cone collapse through distinct intracellular pathways. (2003) (98)
Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome (2018) (96)
Growth cones of developing retinal cells in vivo, on culture surfaces, and in collagen matrices (1985) (95)
On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons (2018) (90)
Axonal mRNAs: Characterisation and role in the growth and regeneration of dorsal root ganglion axons and growth cones (2009) (90)
Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm. (1994) (87)
Electroporation of cDNA/Morpholinos to targeted areas of embryonic CNS in Xenopus (2007) (84)
A role for the fibroblast growth factor receptor in cell fate decisions in the developing vertebrate retina. (1998) (82)
Cell movements in Xenopus eye development (1980) (80)
Effects of intraocular tetrodotoxin on the development of the retinocollicular pathway in the syrian hamster (1989) (77)
miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA (2017) (74)
Fibroblast growth factor receptor signaling in Xenopus retinal axon extension. (1998) (73)
Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation (2013) (70)
Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain (2019) (69)
New views on retinal axon development: a navigation guide. (2004) (68)
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair (2012) (68)
Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation (2007) (68)
Chimeric Integrins Expressed in Retinal Ganglion Cells Impair Process Outgrowth in Vivo (1995) (68)
NF-Protocadherin and TAF1 Regulate Retinal Axon Initiation and Elongation In Vivo (2008) (67)
Precocious pathfinding: Retinal axons can navigate in an axonless brain (1992) (67)
RNA-binding proteins and translational regulation in axons and growth cones (2013) (65)
Local translation and mRNA trafficking in axon pathfinding. (2009) (61)
Retinal axon guidance: novel mechanisms for steering (2004) (59)
Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring (2019) (58)
Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons (2018) (56)
The multiple decisions made by growth cones of RGCs as they navigate from the retina to the tectum in Xenopus embryos. (2000) (55)
Live visualization of protein synthesis in axonal growth cones by microinjection of photoconvertible Kaede into Xenopus embryos (2008) (53)
Differing Semaphorin 3A Concentrations Trigger Distinct Signaling Mechanisms in Growth Cone Collapse (2012) (52)
RNA-Binding Protein Hermes/RBPMS Inversely Affects Synapse Density and Axon Arbor Formation in Retinal Ganglion Cells In Vivo (2013) (51)
Target selection: invasion, mapping and cell choice (1998) (51)
Receptor protein tyrosine phosphatases regulate retinal ganglion cell axon outgrowth in the developing Xenopus visual system. (2001) (51)
A role for S1P signalling in axon guidance in the Xenopus visual system (2007) (51)
Early events in the embryogenesis of the vertebrate visual system: cellular determination and pathfinding. (1990) (50)
Rab5 and Rab4 Regulate Axon Elongation in the Xenopus Visual System (2014) (48)
Inhibition of protein tyrosine kinases impairs axon extension in the embryonic optic tract (1996) (42)
Chondroitin sulfate disrupts axon pathfinding in the optic tract and alters growth cone dynamics. (2002) (42)
Chondroitin sulfates modulate axon guidance in embryonic Xenopus brain. (1998) (42)
The role of cyclic nucleotides in axon guidance. (2007) (40)
Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons (2017) (39)
The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes (2020) (39)
Translational regulation in growth cones. (2011) (39)
Control of retinal growth and axon divergence at the chiasm: lessons from Xenopus (2001) (39)
Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function (2018) (37)
Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones (2015) (37)
Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development (2009) (36)
Regulation of chemotropic guidance of nerve growth cones by microRNA (2011) (35)
Filopodyan: An open-source pipeline for the analysis of filopodia (2017) (33)
ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis (2016) (32)
RNA-based mechanisms underlying axon guidance (2013) (32)
Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons (2019) (31)
From tags to RAGS: Chemoaffinity finally has receptors and ligands (1995) (30)
Tumor protein Tctp regulates axon development in the embryonic visual system (2016) (28)
Local translation of mRNAs in neural development (2011) (28)
Expression of CRYP-α, LAR, PTP-δ, and PTP-ρ in the developing Xenopus visual system (2000) (28)
Role of microRNAs in Semaphorin function and neural circuit formation. (2013) (27)
RNA‐binding protein Vg1RBP regulates terminal arbor formation but not long‐range axon navigation in the developing visual system (2014) (23)
Axon-TRAP-RiboTag: Affinity Purification of Translated mRNAs from Neuronal Axons in Mouse In Vivo. (2018) (23)
Growth factors: a role in guiding axons? (1997) (21)
Neurobiology: Slit, the midline repellent (1999) (21)
A Cytoskeletal Platform for Local Translation in Axons (2008) (21)
Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1 (2016) (19)
Expression of CRYP-alpha, LAR, PTP-delta, and PTP-rho in the developing Xenopus visual system. (2000) (18)
Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones (2018) (18)
14‐3‐3 proteins regulate retinal axon growth by modulating ADF/cofilin activity (2012) (18)
Postnatal changes in the uncrossed retinal projection of pigmented and albino syrian hamsters and the effects of monocular enucleation (1995) (17)
Axonal mRNA translation in neurological disorders (2020) (15)
Absence of topography in precociously innervated tecta. (1995) (15)
NF-Protocadherin Regulates Retinal Ganglion Cell Axon Behaviour in the Developing Visual System (2015) (14)
Total internal reflection fluorescence anisotropy imaging microscopy: setup, calibration, and data processing for protein polymerization measurements in living cells (2017) (13)
Expression of UNC-5 in the developing Xenopus visual system (2002) (12)
Erratum to: Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones (2015) (12)
Expression and herbimycin A‐sensitive localization of pp125FAK in retinal growth cones (1996) (12)
Protein Synthesis Dependence of Growth Cone Collapse Induced by Different Nogo-A-Domains (2014) (12)
Axon microdissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons (2020) (12)
Growth Cone Tctp Is Dynamically Regulated by Guidance Cues (2018) (11)
Retroviral gene transfer inXenopus cell lines and embryos (1996) (10)
Overexpression of c-src and n-src in the DevelopingXenopusRetina Differentially Impairs Axonogenesis (1997) (10)
Outsourcing CREB translation to axons to survive (2008) (10)
Imaging axon pathfinding in Xenopus in vivo. (2012) (9)
The topography of the initial retinotectal projection. (1983) (8)
Introduction to the special issue on local protein synthesis in axons (2014) (8)
Mechanics in neuronal development (2009) (7)
Targeted Electroporation in the CNS in Xenopus Embryos. (2018) (7)
Imaging axon pathfinding in zebrafish in vivo. (2012) (4)
Visual System Development in Vertebrates (2013) (4)
Receptor-Ribosome Coupling: A Link Between Extrinsic Signals and mRNA Translation in Neuronal Compartments. (2022) (3)
Growth factors and neural connectivity. (1996) (3)
Tctp in Neuronal Circuitry Assembly. (2017) (3)
Stimulating New Turns (2001) (2)
Simultaneous in vivo time-lapse stiffness mapping and fluorescence imaging of developing tissue (2018) (2)
Topographic Maps: Molecular Mechanisms (2009) (1)
Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation (2022) (1)
Faculty Opinions recommendation of A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance. (2004) (1)
1.12 – Axon Pathfinding (2007) (1)
mRNA transport, translation, and decay in adult mammalian central nervous system axons (2022) (1)
Hermes regulates axon sorting in the optic tract by post-transcriptional regulation of Neuropilin 1 Abbreviated title : Hermes regulates retinotectal projections (2016) (0)
Faculty Opinions recommendation of The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution. (2001) (0)
VNS volume 4 issue 2 Cover and Back matter (1990) (0)
EMBO Member’s Review Local translation and directional steering in axons (2007) (0)
Author response: Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain (2018) (0)
Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones (2015) (0)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions Graphical Abstract Highlights (2018) (0)
Table S1. MS Identification of AHA-Labeled Spots from DIGE-NCAT Experiment, Related to Figure 2 (2012) (0)
Dedication to Friedrich Bonhoeffer (2004) (0)
20-P020 An involvement of cue-induced regulation of NFPC in retinal growth cone navigation (2009) (0)
Decision letter: Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala (2019) (0)
Faculty Opinions recommendation of Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. (2002) (0)
Faculty Opinions recommendation of Growth cone navigation in substrate-bound ephrin gradients. (2006) (0)
The DCC receptor and its endosome associated role for regulating local protein synthesis (2022) (0)
Target Recognition: Topographic Maps (2006) (0)
Cadherin-mediated cell interactions arenecessary fortheactivation ofMyoDinXenopus mesoderm (1994) (0)
ANATOMY OPTION A: R ESEARCH IN DEVELOPMENTAL BIOLOGY AND NEUROSCIENCE (2006) (0)
Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons (2017) (0)
Erratum to: Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones (2015) (0)
Single Molecule Translation Imaging of Local Protein Synthesis and RNA Docking Reveals the Regulation of Site Specific Axon Remodeling In Vivo (2018) (0)
A Protocol for Single-Molecule Translation Imaging in Xenopus Retinal Ganglion Cells (2020) (0)
Faculty of 1000 evaluation for Wnt-mediated axon guidance via the Drosophila Derailed receptor. (2012) (0)
Axonal mRNA Transport and Functions (2009) (0)
Faculty Opinions recommendation of The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. (2007) (0)
Faculty Opinions recommendation of Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. (2001) (0)
Studying neuronal biomechanics and its role in CNS development (2013) (0)
Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1 (2018) (0)

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Other Resources About Christine Holt

en.wikipedia.org
www.pdn.cam.ac.uk

What Schools Are Affiliated With Christine Holt?

Christine Holt is affiliated with the following schools:

University of Sussex
King's College London
University of Cambridge