Christoph Hiemke
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(Suggest an Edit or Addition)Christoph Hiemke's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Pharmacokinetics of selective serotonin reuptake inhibitors. (2000) (767)
- Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017 (2017) (714)
- A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. (2004) (619)
- AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011. (2014) (555)
- AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011 (2011) (506)
- The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry. (2004) (455)
- Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment (2006) (394)
- Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment (2007) (330)
- CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine (2006) (231)
- Psychosocial stress in tree shrews: Clomipramine counteracts behavioral and endocrine changes (1996) (178)
- Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting (2004) (168)
- Strain Differences in Open-Field and Elevated Plus-Maze Behavior of Rats Without and With Pretest Handling (1998) (163)
- Elevated levels of clozapine in serum after addition of fluvoxamine. (1994) (162)
- Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: differential effects of fluvoxamine and paroxetine in a prospective study. (1998) (152)
- Identification of P‐glycoprotein substrates and inhibitors among psychoactive compounds — implications for pharmacokinetics of selected substrates (2004) (134)
- Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats (2006) (131)
- Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study. (2008) (130)
- Pregabalin abuse and dependence in Germany: results from a database query (2013) (113)
- Therapeutic Monitoring of New Antipsychotic Drugs (2004) (110)
- Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam (2008) (108)
- Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects (2008) (107)
- Kavapyrone enriched extract fromPiper methysticum as modulator of the GABA binding site in different regions of rat brain (1994) (104)
- Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats (2006) (100)
- The Striatal and Extrastriatal D2/D3 Receptor-Binding Profile of Clozapine in Patients with Schizophrenia (2006) (97)
- Combination of open field and elevated plus-maze: A suitable test battery to assess strain as well as treatment differences in rat behavior (1998) (95)
- Increased bioavailability of oral melatonin after fluvoxamine coadministration (2000) (93)
- The Chronic Psychosocial Stress Paradigm in Male Tree Shrews: Evaluation of a Novel Animal Model for Depressive Disorders (2002) (93)
- Effects of Pulsed High-Frequency Electromagnetic Fields on the Neuroendocrine System (1998) (90)
- Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin (2014) (88)
- Chronic psychosocial stress and antidepressant treatment in tree shrews: time-dependent behavioral and endocrine effects (1999) (87)
- Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus (2012) (86)
- TDM in psychiatry and neurology: A comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians* (2018) (85)
- Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017 (2018) (83)
- Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes (1996) (81)
- The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy (2000) (80)
- Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection. (2006) (78)
- Differential Effects of Fluvoxamine and Other Antidepressants on the Biotransformation of Melatonin (2001) (78)
- Enhancement of human cortico-motoneuronal excitability by the selective norepinephrine reuptake inhibitor reboxetine (2002) (76)
- Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat (2007) (76)
- Neuroendocrine response to antipsychotics: effects of drug type and gender (1999) (75)
- The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: A pilot study (2011) (73)
- Nocturnal hormone profiles in patients with schizophrenia treated with olanzapine (2006) (73)
- Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics (2016) (69)
- Addition of low-dose fluvoxamine to low-dose clozapine monotherapy in schizophrenia: drug monitoring and tolerability data from a prospective clinical trial. (1999) (67)
- Combination treatment with clomipramine and fluvoxamine: drug monitoring, safety, and tolerability data. (1996) (65)
- Determination of citalopram and escitalopram together with their active main metabolites desmethyl(es-)citalopram in human serum by column-switching high performance liquid chromatography (HPLC) and spectrophotometric detection. (2007) (64)
- Fluvoxamine Augmentation of Olanzapine in Chronic Schizophrenia: Pharmacokinetic Interactions and Clinical Effects (2002) (64)
- Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography. (2001) (64)
- Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression (2012) (64)
- Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detection. (2005) (64)
- Distribution of clozapine and desmethylclozapine between blood and brain in rats (1999) (63)
- Determination of clozapine and its major metabolites in human serum using automated solid-phase extraction and subsequent isocratic high-performance liquid chromatography with ultraviolet detection. (1992) (62)
- Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions? (2003) (62)
- Inflammation and psychotropic drugs: the relationship between C-reactive protein and antipsychotic drug levels (2016) (60)
- Pharmacogenomics in Psychiatry: From Therapeutic Drug Monitoring to Genomic Medicine (2014) (60)
- Diazepam Has No Beneficial Effects on Stress-Induced Behavioural and Endocrine Changes in Male Tree Shrews (2000) (59)
- Safety of psychotropic medications in people with COVID-19: evidence review and practical recommendations (2020) (59)
- Acute antagonism of dopamine D2-like receptors by amisulpride: effects on hormone secretion in healthy volunteers. (1994) (59)
- Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy (2001) (58)
- A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting risperidone (2017) (58)
- An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. (2021) (58)
- A comprehensive review of the clinical utility of and a combined analysis of the clozapine/norclozapine ratio in therapeutic drug monitoring for adult patients (2019) (57)
- Automated determination of fluvoxamine in plasma by column-switching high-performance liquid chromatography. (1992) (56)
- Characterization of Escherichia coli O157:H7 from Downer and Healthy Dairy Cattle in the Upper Midwest Region of the United States (2003) (55)
- Clinical utility of drug measurement and pharmacokinetics – therapeutic drug monitoring in psychiatry (2008) (55)
- Improved efficacy and fewer side effects under clozapine treatment after addition of fluvoxamine. (1995) (54)
- High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia. (2004) (54)
- Serotonin syndrome as a result of fluoxetine in a patient with tramadol abuse: plasma level-correlated symptomatology. (2002) (54)
- The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants (2005) (53)
- Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice (2008) (53)
- Clinical improvement in a case of frontotemporal dementia under aripiprazole treatment corresponds to partial recovery of disturbed frontal glucose metabolism (2007) (53)
- Appropriateness of Therapeutic Drug Monitoring for Antidepressants in Routine Psychiatric Inpatient Care (2006) (52)
- Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp) (2006) (52)
- Therapeutic Monitoring of Psychotropic Drugs: An Outline of the AGNP-TDM Expert Group Consensus Guideline (2004) (52)
- Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises? (2008) (51)
- Inhibition of synaptosomal high-affinity uptake of dopamine and serotonin by estrogen agonists and antagonists. (1987) (51)
- Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride. (2003) (49)
- Automated determination of amisulpride by liquid chromatography with column switching and spectrophotometric detection. (2003) (48)
- Serum concentrations of paliperidone versus risperidone and clinical effects (2010) (48)
- Effects of escitalopram on the regulation of brain‐derived neurotrophic factor and nerve growth factor protein levels in a rat model of chronic stress (2009) (48)
- Desomorphine Goes “Crocodile” (2012) (45)
- Blood–brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein (2010) (45)
- Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia. (2007) (44)
- Striatal and Extrastriatal D2/D3-Receptor-Binding Properties of Ziprasidone: A Positron Emission Tomography Study With [18F]Fallypride and [11C]Raclopride (D2/D3-Receptor Occupancy of Ziprasidone) (2008) (44)
- Interaction of non-steroidal antiestrogens with dopamine receptor binding. (1984) (44)
- Toxic clozapine serum levels during inflammatory reactions. (2009) (44)
- Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze. (1999) (44)
- Over-expression of two different forms of the α-secretase ADAM10 affects learning and memory in mice (2006) (43)
- CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication. (1997) (43)
- Assessment of storage and transport stability of new antidepressant and antipsychotic drugs for a nationwide TDM service. (2004) (42)
- Therapeutic Plasma Concentrations of Antidepressants and Antipsychotics: Lessons from PET Imaging (2011) (42)
- Evaluation of naltrexone for dissociative symptoms in borderline personality disorder (2012) (42)
- Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie. (2020) (41)
- Interferon-alpha-2-induced stimulation of ACTH and cortisol secretion in man. (1991) (41)
- Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice (2010) (41)
- Population pharmacokinetic analysis of mirtazapine (2004) (40)
- Automated determination of reboxetine by high-performance liquid chromatography with column-switching and ultraviolet detection. (2000) (39)
- Nonlinear pharmacokinetics of fluvoxamine and gender differences. (1998) (39)
- Long-Term Effects of the Substituted Benzamide Derivative Amisulpride on Baseline and Stimulated Prolactin Levels (2002) (39)
- Cognitive Behavioral Therapy Versus Sertraline in Patients With Depression and Poorly Controlled Diabetes: The Diabetes and Depression (DAD) Study (2015) (39)
- Therapeutic drug monitoring for antidepressant drug treatment. (2012) (38)
- Aripiprazole in pregnancy and lactation: a case report. (2010) (38)
- Automated Determination of Paroxetine and Its Main Metabolite by Column Switching and On‐Line High‐Performance Liquid Chromatography (1994) (38)
- The Effect of Age, Sex, Smoking and Co-Medication on Serum Levels of Venlafaxine and O-Desmethylvenlafaxine under Naturalistic Conditions (2012) (38)
- Coadministration of clozapine and fluvoxamine in psychotic patients--clinical experience. (1999) (37)
- Altered brain concentrations of citalopram and escitalopram in P-glycoprotein deficient mice after acute and chronic treatment (2013) (37)
- Monitoring tricyclic antidepressant concentrations in serum by fluorescence polarization immunoassay compared with gas chromatography and HPLC. (1994) (37)
- Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas. (2010) (36)
- Association Between Citalopram Serum Levels and Clinical Improvement of Patients With Major Depression (2011) (36)
- [Olanzapine: pharmacology, pharmacokinetics and therapeutic drug monitoring]. (2004) (36)
- Column switching and high-performance liquid chromatography in the analysis of amitriptyline, nortriptyline and hydroxylated metabolites in human plasma or serum. (1992) (35)
- P.5.c.002 Non-fatal and fatal liver failure associated with valproic acid (2012) (35)
- Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine (2000) (35)
- Circadian variations in antigen-specific proliferation of human T lymphocytes and correlation to cortisol production (1995) (34)
- How Does the Benzamide Antipsychotic Amisulpride get into the Brain?—An In Vitro Approach Comparing Amisulpride with Clozapine (2003) (34)
- Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein (2012) (34)
- Hormonal Influences on Cardiovascular Norepinephrine Transporter Responses in Healthy Women (2008) (34)
- Relationship between mirtazapine dose, plasma concentration, response, and side effects in clinical practice. (2005) (34)
- Reduction of clozapine-induced hypersalivation by pirenzepine is safe. (2004) (33)
- Sex differences in allelic frequencies of the 5‐HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study (2000) (33)
- Genetic polymorphisms of the dopamine D2 and D3 receptor and neuroleptic drug effects in schizophrenic patients (2001) (33)
- Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats (2002) (33)
- Competition by monophenolic estrogens and catecholestrogens for high-affinity uptake of [3H](−)-norepinephrine into synaptosomes from rat cerebral cortex and hypothalamus (1983) (33)
- Attention-Deficit and Disruptive Behavior Disorders (2014) (33)
- Interleukin-6 in plasma collected with an indwelling cannula reflects local, not systemic, concentrations. (1994) (32)
- Automated determination of clomipramine and its major metabolites in human and rat serum by high-performance liquid chromatography with on-line column-switching. (1998) (32)
- A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting paliperidone (2018) (32)
- Chronic Lithium Salt Treatment Reduces CRE/CREB-Directed Gene Transcription and Reverses Its Upregulation by Chronic Psychosocial Stress in Transgenic Reporter Gene Mice (2008) (32)
- Randomized controlled study of early medication change for non-improvers to antidepressant therapy in major depression – The EMC trial (2016) (32)
- Therapeutic Drug Monitoring of the Antidepressant Mirtazapine and Its N-Demethylated Metabolite in Human Serum (2004) (31)
- Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder (2011) (31)
- Stimulation of immediate early gene expression by desipramine in rat brain (1997) (31)
- Automated Determination of Ziprasidone by HPLC With Column Switching and Spectrophotometric Detection (2005) (31)
- Duloxetine serum concentrations and clinical effects. Data from a therapeutic drug monitoring (TDM) survey. (2009) (31)
- HPMA based amphiphilic copolymers mediate central nervous effects of domperidone. (2011) (31)
- A systematic review and combined analysis of therapeutic drug monitoring studies for oral paliperidone (2018) (31)
- Automated determination of dextromethorphan and its main metabolites in human plasma by high-performance liquid chromatography and column switching. (1996) (31)
- Body mass index (BMI) but not body weight is associated with changes in the metabolism of risperidone; A pharmacokinetics-based hypothesis (2016) (31)
- Large Variability of Aripiprazole and Dehydroaripiprazole Serum Concentrations in Adolescent Patients with Schizophrenia (2008) (31)
- Agomelatine and Hepatotoxicity: Implications of Cumulated Data Derived from Spontaneous Reports of Adverse Drug Reactions (2013) (30)
- Automated determination of clozapine and major metabolites in serum and urine. (1997) (30)
- The N-Demethylation of the Doxepin Isomers Is Mainly Catalyzed by the Polymorphic CYP2C19 (2002) (29)
- Gender aspects in the clinical treatment of schizophrenic inpatients with amisulpride: a therapeutic drug monitoring study. (2006) (29)
- Steady-state serum concentrations of venlafaxine in patients with late-life depression. Impact of age, sex and BMI (2015) (29)
- Consensus Guideline Based Therapeutic Drug Monitoring (TDM) in Psychiatry and Neurology. (2016) (29)
- Paroxetine serum concentrations in depressed patients and response to treatment. (2005) (29)
- Pharmacokinetic patterns of risperidone-associated adverse drug reactions (2016) (28)
- Effects of antipsychotic treatment on cognition in healthy subjects (2013) (28)
- Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with Major Depressive Disorder - the EMC trial (2010) (28)
- Phenotyping and genotyping of drug metabolism to guide pharmacotherapy in psychiatry. (2013) (28)
- Abuse of methylphenidate in Germany: Data from spontaneous reports of adverse drug reactions (2014) (28)
- Fishing for a drug: solid-phase microextraction for the assay of clozapine in human plasma. (1999) (27)
- Measurement of Duloxetine in Blood Using High-performance Liquid Chromatography with Spectrophotometric Detection and Column Switching (2007) (27)
- Serum Concentrations of Hydroxybupropion for Dose Optimization of Depressed Patients Treated With Bupropion (2014) (27)
- Differential effects of escitalopram on attention: a placebo-controlled, double-blind cross-over study (2009) (27)
- Effects of ovariectomy and steroid replacement on GABAA receptor binding in female rat brain (1991) (27)
- Rotarod Impairment: Catalepsy-Like Screening Test for Antipsychotic Side Effects (2009) (27)
- Chronic Oral Haloperidol and Clozapine in Rats: A Behavioral Evaluation (1999) (27)
- Therapeutic Drug Monitoring in Italian Psychiatry (2011) (26)
- “Krokodil”—Revival of an Old Drug with New Problems (2012) (26)
- Concentration–Effect Relationships of Psychoactive Drugs and the Problem to Calculate Therapeutic Reference Ranges (2019) (26)
- Fluvoxamine or placebo in the treatment of panic disorder and relationship to blood concentrations of fluvoxamine. (1998) (26)
- Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism (2005) (26)
- A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice. (2010) (26)
- Sub-acute effects of interferon-α 2 on adrenocorticotrophic hormone, cortisol, growth hormone and prolactin in humans (1992) (26)
- Acute, subchronic and discontinuation effects of zopiclone on sleep EEG and nocturnal melatonin secretion (1996) (25)
- Potential Cost-effectiveness of Therapeutic Drug Monitoring for Depressed Patients Treated With Citalopram (2013) (25)
- Effects on enantiomeric drug disposition and open-field behavior after chronic treatment with venlafaxine in the P-glycoprotein knockout mice model (2011) (25)
- Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. (2003) (25)
- Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients (2005) (25)
- Tiagabine, a γ-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-maze (2002) (25)
- Free-choice ethanol consumption under the influence of GABAergic drugs in rats. (2002) (24)
- The value of drug and metabolite concentration in blood as a biomarker of psychopharmacological therapy (2013) (24)
- Side effects related to potentially inappropriate medications in elderly psychiatric patients under everyday pharmacotherapy (2015) (24)
- Serum concentrations of fluvoxamine and clinical effects. A prospective open clinical trial. (1998) (24)
- Interactions and monitoring of antipsychotic drugs. (2012) (23)
- Clinical response in a risperidone-medicated naturalistic sample: patients’ characteristics and dose-dependent pharmacokinetic patterns (2017) (23)
- Increase in serum clomipramine concentrations caused by valproate. (2000) (23)
- Aripiprazole in human milk. (2007) (23)
- The role of cytochrome P450 2D6 in the metabolism of moclobemide (1996) (23)
- Serotonergic modulation of response inhibition and re‐engagement? Results of a study in healthy human volunteers (2010) (23)
- In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes (2012) (23)
- Clozapine plasma level monitoring for prediction of rehospitalization schizophrenic outpatients. (2011) (23)
- Effects of subchronic paroxetine administration on night-time endocrinological profiles in healthy male volunteers (2000) (23)
- Pharmacokinetic Drug-Drug Interactions of Mood Stabilizers and Risperidone in Patients Under Combined Treatment (2016) (22)
- The “DGPPN-Cohort”: a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients (2013) (22)
- Time course of the effects of steroid hormone deprivation elicited by ovariectomy or ovariectomy plus adrenalectomy on the affinity and density of GABA binding sites in distinct rat brain areas. (2009) (22)
- Psychiatric Disorder (2020) (22)
- The Serotonin Transporter Promoter Polymorphism (5-HTTLPR) Affects the Relation between Antidepressant Serum Concentrations and Effectiveness in Major Depression (2011) (22)
- Amisulpride doses and plasma levels in different age groups of patients with schizophrenia or schizoaffective disorder (2009) (22)
- Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia (2009) (22)
- Pharmacokinetics of risperidone in different application forms – Comparing long-acting injectable and oral formulations (2018) (21)
- Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT (1996) (21)
- Therapeutic Drug Monitoring for Drugs Used in the Treatment of Substance-Related Disorders: Literature Review Using a Therapeutic Drug Monitoring Appropriateness Rating Scale (2011) (21)
- Study protocol of the Diabetes and Depression Study (DAD): a multi-center randomized controlled trial to compare the efficacy of a diabetes-specific cognitive behavioral group therapy versus sertraline in patients with major depression and poorly controlled diabetes mellitus (2013) (21)
- Effect of smoking on risperidone pharmacokinetics – A multifactorial approach to better predict the influence on drug metabolism (2017) (20)
- Effects of oestradiol benzoate and progesterone on luteinizing hormone release and catecholamine turnover in the preoptic-hypothalamic brain area of ovariectomized rats. (1983) (20)
- Therapeutic Drug Monitoring for Patients With Alzheimer Dementia to Improve Treatment With Donepezil (2015) (20)
- Appropriateness of plasma level determinations for lithium and valproate in routine care of psychiatric inpatients with affective disorders. (2006) (20)
- Prediction of Antidepressant Response to Venlafaxine by a Combination of Early Response Assessment and Therapeutic Drug Monitoring (2014) (20)
- Elevated risperidone serum concentrations during acute inflammation, two cases (2015) (20)
- The use of ziprasidone in clinical practice: Analysis of pharmacokinetic and pharmacodynamic aspects from data of a drug monitoring survey (2009) (19)
- Induction of c-fos gene expression by the selective sigma receptor ligand EMD 57445 in rat brain (1996) (19)
- Rapid and reliable genotyping procedure for detection of alleles with mutations, deletion, or/and duplication of the CYP2D6 gene. (2009) (19)
- Day- and nighttime content of monoamines and their metabolites in the pineal gland of rat and hamster (1994) (19)
- LC with Column-Switching and Spectrophotometric Detection for Determination of Risperidone and 9-Hydroxyrisperidone in Human Serum (2008) (19)
- Monitoring serum concentrations of clomipramine and metabolites: fluorescence polarization immunoassay versus high performance liquid chromatography. (1997) (18)
- Region specific distribution of levomepromazine in the human brain (2006) (18)
- French summaries of product characteristics: content in relation to therapeutic monitoring of psychotropic drugs (2010) (18)
- What the clinician still has to be reminded of. (2004) (18)
- Sex differences in GABAA receptor binding in rat brain measured by an improved in vitro binding assay (2004) (18)
- Risperidone-induced extrapyramidal side effects: is the need for anticholinergics the consequence of high plasma concentrations? (2016) (18)
- Low concentration of ziprasidone in human milk: a case report. (2009) (17)
- Plasma levels and cerebrospinal fluid penetration by duloxetine in a patient with a non-fatal overdose during a suicide attempt. (2009) (17)
- Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine (2018) (17)
- hs-CRP Predicts Improvement in Depression in Patients With Type 1 Diabetes and Major Depression Undergoing Depression Treatment: Results From the Diabetes and Depression (DAD) Study (2016) (17)
- Low novelty seeking and high self directedness scores in alcohol-dependent patients without comorbid psychiatric disorders homozygous for the A10 allele of the dopamine transporter gene. (2010) (17)
- The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology. (2005) (17)
- Early Improvement and Serum Concentrations of Citalopram to Predict Antidepressant Drug Response of Patients with Major Depression (2013) (17)
- Evidence that 3α-hydroxy-5α-pregnan-20-one is a physiologically relevant modulator of gaba-ergic neurotransmission (1991) (17)
- Therapeutic Drug Monitoring of Long-Acting Injectable Antipsychotic Drugs. (2020) (17)
- High mirtazapine plasma levels in infant after breast feeding: case report and review of the literature. (2009) (17)
- Therapeutisches Drug-Monitoring in der Psychiatrie (2013) (16)
- Differences in Duloxetine Dosing Strategies in Smoking and Nonsmoking Patients: Therapeutic Drug Monitoring Uncovers the Impact on Drug Metabolism. (2018) (16)
- Venlafaxine and O-desmethylvenlafaxine concentrations in plasma and cerebrospinal fluid. (2015) (16)
- Quantification of D 2-Like Dopamine Receptors in the Human Brain with 18 F-Desmethoxyfallypride (2002) (16)
- Interaction of modafinil and clomipramine as comedication in a narcoleptic patient. (1998) (16)
- Association between haemorrhages and treatment with selective and non-selective serotonergic antidepressants: Possible implications of quantitative signal detection (2015) (16)
- Schizophrenic patients who smoke have a faster finger tapping rate than non-smokers (2002) (16)
- Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of carbamazepine and its main metabolites. (1998) (16)
- Reduced clearance of venlafaxine in a combined treatment with quetiapine (2018) (16)
- Value and actuality of the prescription information for therapeutic drug monitoring of psychopharmaceuticals: a comparison with the medico-scientific evidence. (2007) (16)
- Simultaneous Automated Determination of Catecholamines, Serotonin, and Their Metabolites in Brain Tissue by HPLC and Electrochemical Detection (1993) (15)
- Analysis of Multiple Antidepressant and Antipsychotic Drugs Including Active Metabolites in Serum of Psychiatric Patients by LC with Column Switching and Spectrophotometric Detection (2009) (15)
- [Paroxetine: pharmacokinetics and pharmacodynamics]. (1994) (15)
- Prevalence and sort of pharmacokinetic drug–drug interactions in hospitalized psychiatric patients (2020) (15)
- Inhibition of dextromethorphan metabolism by moclobemide (1998) (15)
- „Therapeutic drug monitoring“ in Epileptologie und Psychiatrie (2008) (15)
- Gas-liquid chromatoographic properties of catecholamines, phenylethylamines and indolalkylamines as their propionyl derivatives (1978) (15)
- Actions of sex hormones on the brain (1992) (15)
- Effects of antipsychotic treatment on psychopathology and motor symptoms. A placebo-controlled study in healthy volunteers (2011) (15)
- Spatial Learning and Expression Patterns of PP1 mRNA in Mouse Hippocampus (2010) (15)
- Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues. (1997) (14)
- Preferential uptake of norepinephrine into dopaminergic terminals of a synaptosomal preparation from rat cerebral cortex (1984) (14)
- Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorder. (2013) (14)
- Combination treatment with clozapine and paroxetine in schizophrenia: safety and tolerability data from a prospective open clinical trial (1998) (14)
- Drug‐Induced Liver Injury Associated With Antidepressive Psychopharmacotherapy: An Explorative Assessment Based on Quantitative Signal Detection Using Different MedDRA Terms (2016) (14)
- Day- and night-time contents of monoamines and their metabolites in the medial preoptic area of the rat hypothalamus (1999) (14)
- Elevated Clozapine Concentrations in Clozapine-Treated Patients with Hypersalivation (2020) (14)
- Blood ethanol levels and adenylyl cyclase activity in lymphocytes of alcoholic patients (1999) (14)
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- Risperidone-induced extrapyramidal side effects (2016) (0)
- Therapeutic drug monitoring of clozapine in schizophrenic outpatients (2009) (0)
- DOPAMINE RECEPTOR STIMULATED cAMP, INDIVIDUALLY DIFFERENT DOPAMINERGIC INDUCED MOTILITY AND DOPAMINE RECEPTOR GENES (2000) (0)
- Pharmacokinetic considerations in coprescription of perazine in risperidone medicated patients (2016) (0)
- Determination and Kinetics of CYP450 Isoenzyme Catalyzing Melatonin Biotransformation (2000) (0)
- Predictive Validity (2022) (0)
- Distribution pattern of mirtazapine and normirtazapine in blood and CSF (2014) (0)
- Short communication A determination of amisulpride by liquid chromatography with column switching and spectrophotometric detection (2003) (0)
- Prevalence of Lower-Than-Expected Plasma Levels in Medicated Patients Presenting for Acute Psychiatric Inpatient Treatment (2008) (0)
- Influence of P-glycoprotein (P-gp) induction on the pharmacokinetics of risperidone and paliperidone in mouse brain (2009) (0)
- Activities of Daily Living (2021) (0)
- Authors’ Reply to Suhas et al.: Comment on: “Elevated Clozapine Concentrations in Clozapine-Treated Patients with Hypersalivation” (2021) (0)
- QTc interval alterations during antidepressant treatment with escitalopram and venlafaxine (2022) (0)
- Reality and rational of drug combinations in psychopharmacotherapy (2008) (0)
- 110 AUTOMATED DETERMINATION OF CLOZAPINE, N-DESMETHYLCLOZAPINE AND CLOZAPINE N-OXIDE BY COLUMN SWITCHING AND ON-LINE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (1995) (0)
- Lamotrigine in Bipolar Disorders – Is there an Effective Therapeutic Reference Concentration? (2008) (0)
- Measuring psychopathology by HAMD and CGI ratings to guide antidepressant treatment under naturalistic conditions (2011) (0)
- P-glycoprotein (P-gp) affects the pharmacodynamics and of the atypical antipsychotic amisulpride (2004) (0)
- Does Addiction (Alcohol, Benzodiazepines) Diseases Affect the Pharmacokinetics of Escitalopram? – Data from a Naturalistic Study (2008) (0)
- Subject Index Vol. 61, 2010 (2010) (0)
- PSYCHOPATHOLOGICAL AND ENDOCRINE EFFECTS OF INTERFERON‐ALPHA‐2 (1992) (0)
- [Standardized documentation procedure as a basis for improvement of process quality of treatment in psychiatric hospitals]. (2003) (0)
- [Therapeutic drug monitoring of new antidepressives and antipsychotics]. (2003) (0)
- Effects of age, gender, smoking and co-medication on the pharmacokinetics of venlafaxine and O-desmethylvenlafaxine in everyday clinical practice (2009) (0)
- 2 Drug interactions in patients undergoing opioid maintenance therapy (2020) (0)
- Dihydrotestosterone and Estradiol Regulating the Activity of 3α-Hydroxysteroid Dehydrogenase in the Pituitary Gland of the Rat: Action of Antiestrogens (1981) (0)
- PLASMA LEVELS OF NEUROLEPTIC DRUG AND PROLACTIN AFTER ACUTE DOSES OF BENPERIDOL (1992) (0)
- Inflammation and psychotropic drugs: the relationship between C-reactive protein and antipsychotic drug levels (2015) (0)
- Therapeutic drug monitoring for patients with bipolar disorders. Useful or useless (2014) (0)
- The Influence of Therapeutic Drug Monitoring (TDM) and Objective Symptom Rating for Prediction of Antipsychotic Response to Second-Generation Antipsychotic Drugs (2008) (0)
- Automated Analysis of Antipsychotic Drugs Using Liquid Chromatography with Column Switching (2005) (0)
- Is the estrogen-induced LH-surge in female rats triggered by noradrenalin or adrenalin? (1986) (0)
- Pharmacotherapy of old aged patients (2014) (0)
- Flurazepam (2020) (0)
- Therapeutic Drug Monitoring in Psychiatry (2011) (0)
- Therapeutic drug monitoring and objective symptom rating for optimization of antipsychotic drug therapy (2007) (0)
- Aripiprazole use during pregnancy and lactation (2011) (0)
- Interaction of antiestrogens with the in vitro binding of radioligands to catecholamine receptors (1984) (0)
- Retinoid-based therapy of Alzheimer's disease A proof of mechanism study (2011) (0)
- Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. (2022) (0)
- 12 Therapeutic Drug Monitoring in the relapse prevention treatment of alcohol dependence (2020) (0)
- SPCCTDM, a Catalogue for Analysis of Therapeutic Drug Monitoring Related Contents (2012) (0)
- The influence of inflammatory reactions on the serum concentration of clozapine (2009) (0)
- Characterization of Escherichia coli O 157 : H 7 from Downer and Healthy Dairy Cattle in the Upper Midwest Region of the United States C (2017) (0)
- Multi-Drug-Resistance proteins affect antipsychotic treatment: in vivo effects of aripiprazole (2007) (0)
- Antipsychotic Drug Levels in Psychiatric Primary Care Patients (2008) (0)
- BIDIRECTIONAL DRUG INTERACTIONS BETWEEN FLUVOXAMINE AND TRICYCLIC ANTIDEPRESSANTS (1992) (0)
- Forced swim-test-related antidepressant effects depend on P-glycoprotein expression in the Blood-Brain-Barrier (2009) (0)
- P.2.b.009 Regulation of the astrocytic proteins NDRG2 and GFAP in the rat hippocampus by chronic social stress: no reversal by citalopram (2012) (0)
- Therapeutic reference range for aripiprazole revised: A systematic review and combined analysis (2022) (0)
- P-515 - CGI Rating to Predict Antidepressant Treatment Under Naturalistic Conditions (2012) (0)
- Influence of Age, Gender, Smoking Habits and Comedication on Serum Levels of Venlafaxine and O-Desmethylvenlafaxine under Naturalistic Conditions (2008) (0)
- The clinical relevance of the pharmacological interaction between clozapine and sertraline (2019) (0)
- Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients (2016) (0)
- Automated Determinationof Fluvoxaminein Plasma by Column-Switching High-PerformanceLiquid Chromatography (1992) (0)
- Therapeutic drug monitoring of bupropion for depression (2012) (0)
- P2-453 TESTING THE THERAPEUTIC POTENTIAL OF DOXYCYCLINE IN A DROSOPHILA MELANOGASTER MODEL OFALZHEIMER’S DISEASE (2019) (0)
- Potentially Inappropriate Medication in Patients Admitted with Diagnosis of Delirium Superimposed on Dementia (2018) (0)
- [Important to atypical antipsychotics: pharmacokinetics, interaction potential and therapeutic drug monitoring]. (2002) (0)
- Monitoring clomipramine and its hydroxylated metabolites in serum by fluorescence polarization immunoassay compared with HPLC (1995) (0)
- P.559 How to find therapeutic reference ranges for psychotropic drugs: combining population-derived pharmacodynamic and pharmacokinetic principles with an evidence-based methodological approach (2019) (0)
- Candidate genes for learning and memory: microarray analysis of mouse hippocampi during acquisition of the Morris water maze task (2005) (0)
- PT705. Therapeutic Drug Monitoring (TDM) in maternal serum, amniotic fluid and umbilical cord blood during pregnancy and delivery (2016) (0)
- Therapeutic drug monitoring (TDM) and clinical outcomes in forensic patients under clozapine therapy compared to therapies with other antipsychotic drugs (2012) (0)
- Therapeutic drug monitoring of aripiprazole (2005) (0)
- Costs and effectiveness of therapeutic drug monitoring in psychiatry (2004) (0)
- Therapeutic Drug Monitoring (TDM) of donepezil in patients with Alzheimers dementia (2013) (0)
- How to find the therapeutic reference range for psychoactive drugs (2016) (0)
- Pharmacokinetic and Pharmacodynamic Principles (2020) (0)
- Use Of Therapeutic Drug Monitoring In Depressive Inpatients Under Naturalistic Conditions: 91 (2005) (0)
- 39-149 The effects of subchronic paroxetine administration on sleep EEG and night-time endocrinological profiles in healthy male volunteers (1997) (0)
- Personalised medicine in psychiatry? Yes, but how? (2014) (0)
- 14-138 Effect of antidepressant medication on the cytochrome P450 2D6 (CYP2D6) phenotype (1997) (0)
- SUBCELLULAR DISTRIBUTION AND GONADAL REGULATION OF 3α-HYDROXYSTEROID DEHYDROGENASE (3α-HSDH) IN RAT PITUITARY (1980) (0)
- O-18 - TDM in Patients With Substance Related Disorders (2012) (0)
- A new model for the induction of proestrus-like LH surges by estradiol in long-term ovariectomized rats (1985) (0)
- Does Functional Imaging of the CNS Replace Assessment of Drug Concentrations in Serum (2008) (0)
- How much citalopram is equivalent to 50 ng/ml sertraline? Standardization of serum concentrations of six different SSRIs by measuring serotonin transporter occupancy (2011) (0)
- Consequences of P-gp deficiency for the phenotype of FVB/N (mdr1a/1b -/-) mice and resulting alterations in HPA-System activity (2009) (0)
- P.3.c.023 Treatment of different target syndromes of schizophrenia with amisulpride: a therapeutic drug monitoring study (2007) (0)
- Pharmacokinetic patterns of risperidone-associated adverse drug reactions (2016) (0)
- PHARMACOKINETICS A ND D ISPOSITION (2004) (0)
- Subprojekt 3.8. des Kompetenznetzes „Depression/Suizidalität" im Teilprojekt 3 „Qualitätsmanagement in der Depressionsbehandlung" (2003) (0)
- APOMORPHINE-INDUCED BEHAVIORAL-PATTERNS ARE ASSOCIATED TO D2-DOPAMINE RECEPTOR GENE POLYMORPHISMS (2000) (0)
- Schizophrenia patients who smoke have a faster finger tapping rate (2002) (0)
- Therapeutic drug monitoring for improved psychopharmacotherapy in elderly patients (2014) (0)
- Induction of p-gp affects pharmacodynamics of its substrates (2013) (0)
- Concentrations of Venlafaxine, Mirtazapine and Citalopram in serum and cerebrospinal fluid – a naturalistic approach (2015) (0)
- What is an animal model ? (2005) (0)
- Erratum zu: Therapeutisches Drug-Monitoring in der Neuropsychopharmakologie (2019) (0)
- Serotonin-selektive Antidepressiva(SSRI, DSA) (2002) (0)
- Pharmacokinetic considerations of different dosing regimens in clozapine medicated patients (2016) (0)
- 22 Using TDM to improve efficacy and safety outcomes of antipsychotic treatment (2020) (0)
- Nocturnal Hormone Profiles in Healthy Humans Under the Influence of Pulsed High-Frequency Electromagnetic Fields (2001) (0)
- CME Courses (0)
- Relation between leukocyte counts and cortisol secretion in CML patients undergoing combined TNF alpha/IFN alpha therapy. (1992) (0)
- Validation of four drug interaction programs for psychopharmacotherapy (2011) (0)
- Information search and software use in TDM laboratories – a survey (2011) (0)
- Melperone but not metoprolol is a clinically relevant inhibitor of CYP2D6 (2014) (0)
- Methylphenidate challenge test in adults with attention deficit/hyperactivity disorder (ADHD): Clinical effects and their predictors (2020) (0)
- Rapid and Reliable Genotyping Procedure for Detection of Alleles with Mutation, Deletion or/and Duplication of the CYP2D6-Gene (2005) (0)
- Repetitive Behavior (2021) (0)
- 14-18 Benzodiazepine receptor occupancy during benzodiazepine treatment measured with 1231-lomazenil-SPECT: A survey of different studies (1997) (0)
- Antiestrogen inhibition of estradiol-induced alterations in hypothalamic catecholamine turnover (1987) (0)
- Age-dependency of psychotropic drug-induced anticholinergic adverse reactions: Analysis of reports to the pharmacovigilance system AGATE (2013) (0)
- Adverse Drug Reactions, Intoxications and Interactions of Neuropsychotropic Medications (2020) (0)
- Ines Gaertner in Memoriam (2005) (0)
- TDM in psychiatric hospitals. Data from a German survey (2014) (0)
- Pharmacokinetics of venlafaxine in treatment responders and non-responders: a retrospective analysis of a large naturalistic database (2019) (0)
- IN VITRO METABOLISM OF THE TRICYCLIC ANTIDEPRESSANT DOXEPIN (1999) (0)
- Therapeutic Drug Monitoring of Antidepressants and Length of Stay of Psychiatric Inpatients (2005) (0)
- Therapeutic drug monitoring (TDM) of donepezil (2004) (0)
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What Schools Are Affiliated With Christoph Hiemke?
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