Christopher Alan Bradfield
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Christopher Alan Bradfieldbiology Degrees
Biology
#12233
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#15696
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Molecular Biology
#1964
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#1995
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Neuroscience
#2036
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#2092
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Biology
Christopher Alan Bradfield's Degrees
- PhD Neuroscience University of California, San Diego
- Bachelors Biology University of California, San Diego
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(Suggest an Edit or Addition)Christopher Alan Bradfield's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals (2000) (1402)
- Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes (2010) (1264)
- An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells (2010) (1188)
- The PAS superfamily: sensors of environmental and developmental signals. (2000) (1057)
- Ah receptor signaling pathways. (1996) (924)
- Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. (1996) (906)
- Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT (1997) (809)
- Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. (1992) (794)
- The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. (1998) (759)
- AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch (2011) (676)
- The search for endogenous activators of the aryl hydrocarbon receptor. (2008) (656)
- Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. (1998) (576)
- Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1991) (563)
- Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway* (1997) (530)
- The AH-receptor: genetics, structure and function. (1993) (424)
- Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo* (1997) (421)
- DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins (*) (1995) (402)
- Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. (2000) (387)
- Obesity in mice with adipocyte-specific deletion of clock component Arntl (2012) (369)
- The aryl hydrocarbon receptor: a perspective on potential roles in the immune system (2009) (353)
- Cloning and expression of a human Ah receptor cDNA. (1993) (338)
- Mammalian Per-Arnt-Sim proteins in environmental adaptation. (2010) (319)
- Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse (1998) (290)
- Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice (2006) (286)
- Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion (2015) (268)
- Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation. (2005) (256)
- Identification of toxicologically predictive gene sets using cDNA microarrays. (2001) (238)
- In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. (1993) (233)
- Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity and Abnormal Liver Development in Mice Carrying a Mutation in the Nuclear Localization Sequence of the Aryl Hydrocarbon Receptor* (2003) (218)
- Characterization of the Ah Receptor-associated Protein, ARA9* (1998) (205)
- Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. (2005) (200)
- Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal‐1 locus (2005) (196)
- Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator. (1998) (192)
- Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways (1999) (187)
- Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism. (1987) (185)
- Tissue specific expression of the rat Ah-receptor and ARNT mRNAs. (1994) (179)
- The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems (2007) (177)
- Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. (1998) (169)
- Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini. (1994) (166)
- Ahr null alleles: distinctive or different? (1998) (158)
- The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse (2005) (155)
- Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice (2005) (149)
- Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. (1993) (143)
- The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system. (1994) (142)
- Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor (2008) (139)
- Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo (2008) (135)
- Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione S-transferase and epoxide hydrolase activities in the rat. (1984) (134)
- Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. (2004) (131)
- Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. (2012) (130)
- Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant (2014) (128)
- The Aryl hydrocarbon receptor is activated by modified low-density lipoprotein (2007) (127)
- Patent Ductus Venosus and Dioxin Resistance in Mice Harboring a Hypomorphic Arnt Allele* (2004) (126)
- ARA9 Modifies Agonist Signaling through an Increase in Cytosolic Aryl Hydrocarbon Receptor* (2000) (118)
- Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis. (2001) (116)
- The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia Factors (2000) (115)
- Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor. (2003) (100)
- Aryl hydrocarbon receptor response to indigoids in vitro and in vivo. (2004) (97)
- Reduced Nitric Oxide Causes Age-Associated Impairment of Circadian Rhythmicity (2008) (95)
- The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology (2009) (93)
- Deletion of the Aryl Hydrocarbon Receptor-associated Protein 9 Leads to Cardiac Malformation and Embryonic Lethality* (2007) (92)
- Kinetic and equilibrium studies of Ah receptor-ligand binding: use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin. (1988) (83)
- Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice (2014) (82)
- High-performance liquid chromatographic analysis of anticarcinogenic indoles in Brassica oleracea (1987) (81)
- Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. (1991) (79)
- Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR) (2017) (79)
- Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis (2016) (76)
- EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information (2005) (74)
- Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex (2017) (71)
- The aryl hydrocarbon receptor controls cell-fate decisions in B cells (2017) (71)
- Liver Deformation in Ahr-Null Mice: Evidence for Aberrant Hepatic Perfusion In Early Development (2006) (70)
- Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase (2014) (70)
- Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron. (2019) (70)
- A competitive binding assay for 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands of the Ah receptor. (1988) (68)
- Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten. (1991) (68)
- The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse (2016) (67)
- Sequence variation and phylogenetic history of the mouse Ahr gene. (2002) (67)
- Mapping the 90 kDa heat shock protein binding region of the Ah receptor (1996) (65)
- Advances in toxicogenomics. (2005) (61)
- Identification of the Ah-receptor structural determinants for ligand preferences. (2012) (58)
- The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model (2020) (56)
- Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β. (2013) (55)
- Aspects of Dioxin Toxicity Are Mediated by Interleukin 1-Like Cytokines (2005) (55)
- Effects of commonly consumed vegetables on hepatic xenobiotic-metabolizing enzymes in the mouse. (1985) (52)
- Association of peroxisome proliferator-activated receptor and Hsp72. (1994) (51)
- A Hypomorphic Allele of Aryl Hydrocarbon Receptor-Associated Protein-9 Produces a Phenocopy of the Ahr-Null Mouse (2008) (46)
- The Aryl Hydrocarbon Receptor-interacting Protein (AIP) Is Required for Dioxin-induced Hepatotoxicity but Not for the Induction of the Cyp1a1 and Cyp1a2 Genes* (2010) (45)
- Molecular characterization of the murine Hif-1 alpha locus. (1997) (44)
- SU5416, a VEGF Receptor Inhibitor and Ligand of the AHR, Represents a New Alternative for Immunomodulation (2012) (43)
- Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver. (2010) (42)
- Modification of carcinogen metabolism by indolylic autolysis products of Brassica oleraceae. (1991) (41)
- Baculovirus expression of the Ah receptor and Ah receptor nuclear translocater. Evidence for additional dioxin responsive element-binding species and factors required for signaling. (1994) (41)
- Hepatic transcriptional networks induced by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2007) (39)
- Aggregate culture of human embryonic stem cell-derived hepatocytes in suspension are an improved in vitro model for drug metabolism and toxicity testing. (2014) (39)
- Transforming Growth Factor-β3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin* (2005) (38)
- Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. (2014) (37)
- Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid. (2009) (35)
- Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster. (2009) (35)
- Immunology: T cells hang in the balance (2008) (34)
- D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. (2009) (34)
- Application of genomics to toxicology research. (2002) (32)
- Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro (2018) (31)
- A Maternal Ahr Null Genotype Sensitizes Embryos to Chemical Teratogenesis* (2004) (31)
- Interaction Networks in Yeast Define and Enumerate the Signaling Steps of the Vertebrate Aryl Hydrocarbon Receptor (2004) (29)
- Dietary modification of xenobiotic metabolism: contribution of indolylic compounds present in Brassica oleracea (1987) (29)
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Premature Activation of the KLF2 Regulon during Thymocyte Development* (2007) (29)
- Induction of Cytochrome P450 Enzymes (2005) (28)
- Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin (2011) (28)
- Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease (2018) (27)
- EDGE3: A web-based solution for management and analysis of Agilent two color microarray experiments (2009) (26)
- Chromosomal localization of the human AHR locus encoding the structural gene for the Ah receptor to 7p21-->p15. (1994) (24)
- Clustered alignments of gene-expression time series data (2009) (21)
- The aryl hydrocarbon receptor influences transplant outcomes in response to environmental signals (2012) (18)
- Ambient urban dust particulate matter reduces pathologic T cells in the CNS and severity of EAE (2019) (18)
- Transforming growth factor-beta3 restores fusion in palatal shelves exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2005) (17)
- Similarity Queries for Temporal Toxicogenomic Expression Profiles (2008) (17)
- The Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Modified by a Locus on Mouse Chromosome 3 (2006) (17)
- The Aryl Hydrocarbon Receptor Signaling Pathway Is Modified through Interactions with a Kelch Protein (2006) (16)
- The AH Receptor (2003) (14)
- The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver (2019) (13)
- A brief review of the Ah locus. (1992) (13)
- Transcriptomic analysis reveals similarities in genetic activation of detoxification mechanisms resulting from imidacloprid and chlorothalonil exposure (2018) (12)
- A time to divide: does the circadian clock control cell cycle? (2006) (11)
- Gene expression pattern Expression of ARNT, ARNT2, HIF1a, HIF2a and Ah receptor mRNAs in the developing mouse (1998) (11)
- Agricultural fungicides inadvertently influence the fitness of Colorado potato beetles, Leptinotarsa decemlineata, and their susceptibility to insecticides (2018) (10)
- Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. (2018) (8)
- 8 Induction of Cytochrome P 450 Enzymes (7)
- Developing toxicologically predictive gene sets using cDNA microarrays and Bayesian classification. (2002) (7)
- The aryl hydrocarbon receptor as a model PAS sensor (2021) (7)
- EPA dioxin reassessment. (1994) (7)
- The PPCD1 Mouse: Characterization of a Mouse Model for Posterior Polymorphous Corneal Dystrophy and Identification of a Candidate Gene (2010) (7)
- Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach. (2021) (6)
- M olecular Characterization and Chromosomal Localization o f a Third a-C lass H ypoxia Inducible Factor Subunit, H IF 3a (2016) (6)
- METABOLIC HEALTH Pancreatic b cell enhancers regulate rhythmic transcription of genes controlling insulin secretion (2015) (6)
- www.cognizantcommunication.com Identification of Novel Peroxisome Proliferator-Activated Receptor α (PPAR α ) Target Genes in Mouse Liver Using cDNA Microarray (2001) (5)
- Rodent genetic models of Ah receptor signaling (2021) (4)
- Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression (2016) (3)
- Author response: Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant (2014) (2)
- Retinal pathology in the PPCD1 mouse (2017) (1)
- Correction: Similarity Queries for Temporal Toxicogenomic Expression Profiles (2008) (1)
- Application of DNA microarrays for predicting toxicity and evaluating cross-species extrapolation (2003) (1)
- 8.09 – The Aryl Hydrocarbon Receptor as a Regulator of Barrier Physiology (2018) (1)
- Generation of allelic series in mice by gene targeting. (1998) (1)
- Modulation of the Onset and Severity of EAE with Ligands of the Aryl Hydrocarbon Receptor (2011) (0)
- Enhanced sensitivity of an Ah-receptor system in yeast through condition modification and use of mammalian modifiers (2022) (0)
- Molecular Biology of Breast Neoplasia (1995) (0)
- BIOINFORMATICS Clustered alignments of gene-expression time series data (2009) (0)
- CDK7 is a Novel Therapeutic Vulnerability in Fibrolamellar Carcinoma (2023) (0)
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Premature Activation of the KLF2 Regulon during (2007) (0)
- Acknowledgement to referees 2003 (2004) (0)
- The Influence of the Aryl Hydrocarbon Receptor on Graft Survival and T-Cell Differentiation in a Promising Model of Organ Transplantation (2010) (0)
- DeletionoftheArylHydrocarbonReceptor-associatedProtein9 LeadstoCardiacMalformationandEmbryonicLethality * (2007) (0)
- Alan Poland, MS, MD: 1940-2020 Poisons as Probes of Biological Function. (2020) (0)
- Ah‐Receptor (Dioxin Receptor) (2002) (0)
- An Introduction to Toxicogenomics (2010) (0)
- The Ah-receptor cDNA is a novel ligand activated transcription factor (1992) (0)
- Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model (2023) (0)
- Genomics and proteomics (2002) (0)
- Mechanisms of AH receptor action (2009) (0)
- The Ah Locus: A Review (1994) (0)
- Abstract 449: Circadian Clock Components Regulate the Thrombotic Response to Injury (2007) (0)
- Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease (2018) (0)
- Crystal structure of the AHR-ARNT heterodimer in complex with the DRE (2017) (0)
- A Hypomorphic Allele of A ryl-hydrocarbon Receptor-associated-protein-9 Produces a Phenocopy of the A hr Null (2008) (0)
- The NRC's report on pesticides in children (1994) (0)
- The circadian clock is disrupted in pancreatic cancer (2023) (0)
- The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse □ S (2005) (0)
- The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver (2019) (0)
- The Aryl Hydrocarbon Receptor is a Repressor of Inflammation- umorigenesis in Mouse associated Colorectal T (2016) (0)
- Measuring the Responsome: Transcriptional Differences in mRNA Expression by Smoking Status and Obesity as Biomarkers for Human Sensitivity to Environmental Exposures (2018) (0)
- Aryl Hydrocarbon Receptor Can Generate An Interaction between Kynurenine and the (2010) (0)
- 12382 Circadian Disruption in Pancreatic Cancer Carcinogenesis (2021) (0)
- Gene Targeting (2001) (0)
- Running title: Dioxin hepatotoxicity. Corresponding author: (2017) (0)
- Abstract 3811: Circadian disruption enhances development of pancreatic inflammation and pancreatic cancer precursors (2020) (0)
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What Schools Are Affiliated With Christopher Alan Bradfield?
Christopher Alan Bradfield is affiliated with the following schools:
