Christopher E. Rudd

Christopher E. Rudd's AcademicInfluence.com Rankings

Christopher E. Rudd

Biology

#5321

World Rank

#7774

Historical Rank

Immunology

#256

World Rank

#266

Historical Rank

biology Degrees

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Biology

Christopher E. Rudd's Degrees

Bachelors Immunology University of British Columbia

Why Is Christopher E. Rudd Influential?

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According to Wikipedia, Christopher Edward Rudd, is a Canadian-born immunologist-biochemist. He is currently Professor of Medicine at the Universite de Montreal and Director, Immunology-Oncology at the Centre de Recherche Hôpital Maisonneuve-Rosemont .

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Christopher E. Rudd's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

CD28 and CTLA‐4 coreceptor expression and signal transduction (2009) (729)
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. (1988) (616)
Reversal of the TCR Stop Signal by CTLA-4 (2006) (609)
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. (2000) (567)
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2014) (455)
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. (1989) (404)
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling (2003) (400)
Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap (2001) (302)
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. (1994) (298)
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. (1997) (276)
Upstream-downstream: CD28 cosignaling pathways and T cell function. (1996) (242)
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. (1997) (234)
Adaptors and Molecular Scaffolds in Immune Cell Signaling (1999) (228)
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. (1995) (190)
1F7, a novel cell surface molecule, involved in helper function of CD4 cells. (1989) (180)
Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases. (1994) (180)
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells (1995) (172)
T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras (1995) (166)
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. (1993) (165)
SH3 domain recognition of a proline‐independent tyrosine‐based RKxxYxxY motif in immune cell adaptor SKAP55 (2000) (161)
CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor. (1990) (159)
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. (1999) (150)
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase (1993) (150)
Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function (2001) (146)
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. (1994) (142)
Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. (1995) (140)
A functional dichotomy in CD4+ T lymphocytes. (1988) (139)
Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling* (1998) (138)
YopH dephosphorylates Cas and Fyn-binding protein in macrophages. (1999) (133)
CTLA-4 trafficking and surface expression. (2008) (130)
Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse (2010) (129)
The reverse stop-signal model for CTLA4 function (2008) (129)
CD28 and Lipid Rafts Coordinate Recruitment of Lck to the Immunological Synapse of Human T Lymphocytes1 (2004) (127)
SKAP-55 regulates integrin adhesion and formation of T cell–APC conjugates (2003) (127)
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. (2005) (125)
CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. (2001) (125)
CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn. (1992) (119)
FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (1998) (117)
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses (2016) (116)
Molecular Interactions, T‐Cell Subsets and a Role of the CD4/CD8:p56lck Complex in Human T‐Cell Activation (1989) (115)
T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. (2010) (113)
A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells (1987) (112)
Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen (1987) (109)
SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages (1999) (108)
CTLA‐4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization (2008) (104)
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes. (1996) (103)
The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens (1987) (102)
FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells* (1999) (102)
CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy (2018) (101)
T-cell signalling and immune system disorders (2005) (99)
ADAP–SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell–APC Conjugation (2004) (98)
Protein tyrosine phosphorylation in T cell signaling. (2002) (94)
Functional expression of HLA-DP genes transfected into mouse fibroblasts (1985) (93)
CTLA-4 Activation of Phosphatidylinositol 3-Kinase (PI 3-K) and Protein Kinase B (PKB/AKT) Sustains T-Cell Anergy without Cell Death (2008) (90)
The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells. (1986) (90)
Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Isoforms Alternatively Inhibit and Costimulate Human T Cell Function1 (2004) (86)
SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion. (2008) (84)
src-related protein tyrosine kinases and their surface receptors. (1993) (84)
The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck (1994) (83)
Membrane Rafts Play a Crucial Role in Receptor Activator of Nuclear Factor κB Signaling and Osteoclast Function* (2003) (82)
Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition. (2000) (80)
CD28 co-signaling in the adaptive immune response. (2010) (77)
Novel Isoform of Lymphoid Adaptor FYN-T-binding Protein (FYB-130) Interacts with SLP-76 and Up-regulates Interleukin 2 Production* (1999) (74)
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility (2009) (74)
Association of a 70‐kDa tyrosine phosphoprotein with the CD16:ζ:γ complex expressed in human natural killer cells (1993) (74)
Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy. (2018) (74)
Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651. (1999) (72)
Cutting Edge: Regulator of G Protein Signaling-1 Selectively Regulates Gut T Cell Trafficking and Colitic Potential (2011) (72)
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. (2006) (71)
Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: Differential involvement of the FYB SH3 domain (2001) (70)
Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice1 (2002) (69)
CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. (1998) (64)
2H1--a novel antigen involved in T lymphocyte triggering. (1988) (63)
Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells* (2000) (61)
An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R (2005) (57)
Isolation and characterization of a human T lymphocyte-associated glycoprotein (gp40). (1984) (56)
Lymphokine regulation of CD45R expression on human T cell clones (1989) (56)
TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes (2015) (54)
Biochemistry of Class II Antigens: Workshop Report (1984) (54)
Functional Defects of SKAP-55-Deficient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion (2007) (53)
Decreased CD8‐p561ck Activity in Peripheral Blood T‐Lymphocytes from Patients with Hereditary Haemochromatosis (1994) (52)
Lnk Adaptor: Novel Negative Regulator of B Cell Lymphopoiesis (2001) (51)
Lymphocyte signaling: Cbl sets the threshold for autoimmunity (2000) (51)
T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T) (1993) (51)
FcγRIIIA-mediated signaling involves src-family lck in human natural killer cells (1993) (50)
Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain. (1996) (50)
Diverse Mechanisms Regulate the Surface Expression of Immunotherapeutic Target CTLA-4 (2014) (49)
The Fes Protein-Tyrosine Kinase Phosphorylates a Subset of Macrophage Proteins That Are Involved in Cell Adhesion and Cell-Cell Signaling* (1997) (49)
Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kD. (1992) (49)
A 32-kD GTP-binding protein associated with the CD4-p56lck and CD8-p56lck T cell receptor complexes. (1991) (48)
TcR and TcR-CD28 Engagement of Protein Kinase B (PKB/AKT) and Glycogen Synthase Kinase-3 (GSK-3) Operates Independently of Guanine Nucleotide Exchange Factor VAV-1* (2006) (48)
Independent CD28 signaling via VAV and SLP‐76: a model for in trans costimulation (2003) (47)
Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells (2006) (46)
Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells. (1997) (45)
Function of the LFA‐1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes (1986) (44)
A regulatory role for cytoplasmic YVKM motif in CTLA‐4 inhibition of TCR signaling (2001) (41)
Structural characterization of CD6: properties of two distinct epitopes involved in T cell activation. (1989) (40)
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal. (2012) (40)
Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8+ Cytotoxic T-Cells: Implications for anti-PD-1 Immunotherapy (2017) (39)
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (2008) (39)
Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA-4 and its association with PI-3 kinase in intracellular compartments of T-cells. (2001) (38)
SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1 (2011) (38)
Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. (1998) (38)
Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells. (1995) (37)
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy (2015) (37)
CTLA-4 blockade of antigen-induced cell death. (2001) (36)
CTLA‐4 co‐receptor impacts on the function of Treg and CD8+ T‐cell subsets (2009) (35)
Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system (1989) (33)
Regulation and Function of SKAP-55 Non-canonical Motif Binding to the SH3c Domain of Adhesion and Degranulation-promoting Adaptor Protein* (2006) (33)
Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2016) (32)
Role of the 2H4 molecule in the activation of suppressor inducer function (1988) (32)
A role for adhesion and degranulation‐promoting adapter protein in collagen‐induced platelet activation mediated via integrin α2β1 (2012) (32)
HLA-D region antigen-associated invariant polypeptides as revealed by two-dimensional gel analysis. Glycosylation and structural inter-relationships. (1985) (32)
CTLA-4 Negative Signaling via Lipid Rafts: A New Perspective (2002) (32)
B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling (2020) (30)
Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity. (2020) (30)
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation (2017) (29)
Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. (1991) (29)
The Chemokine CXCL12 Generates Costimulatory Signals in T Cells to Enhance Phosphorylation and Clustering of the Adaptor Protein SLP-76 (2013) (29)
CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase: common co-signals induced by CD80 and CD86. (1996) (29)
Phosphatidylinositol‐3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells (2004) (28)
GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response (2020) (28)
Signaling scaffolds in immune cells. (1999) (28)
Ganglioside-induced CD4 endocytosis occurs independent of serine phosphorylation and is accompanied by dissociation of P56lck. (1992) (27)
The CD4/CD8:p56lck complex in T lymphocytes: a potential mechanism to regulate T-cell growth. (1989) (26)
CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase1 (2007) (26)
MAPK p38: alternative and nonstressful in T cells (2005) (26)
Phosphatidylinositol 3-Kinase p85 Adaptor Function in T-cells (2002) (26)
TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice. (2008) (26)
Positive and negative adaptors in T‐cell signalling (2004) (26)
Immunopathologies linked to integrin signalling (2010) (25)
Two-step TCR /CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, (1994) (25)
The HIV‐1 Surface Protein gp120 Has No Effect on Transmembrane Signal Transduction in T Cells (1992) (25)
Disabled receptor signaling and new primary immunodeficiency disorders. (2006) (25)
Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells. (2017) (24)
CD45 ligation expands Tregs by promoting interactions with DCs. (2014) (23)
The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells (2015) (23)
Rab8 Binding to Immune Cell-Specific Adaptor LAX Facilitates Formation of trans-Golgi Network-Proximal CTLA-4 Vesicles for Surface Expression (2014) (23)
Adaptor ADAP (adhesion- and degranulation-promoting adaptor protein) regulates beta1 integrin clustering on mast cells. (2001) (23)
Molecular analysis of the interaction of p56lck with the CD4 and CD8 antigens. (1991) (22)
SIGNALLING SCAFFOLDS AND ADAPTORS IN T‐CELL IMMUNITY (2002) (22)
Microtubules, colchicine, and lymphocyte blastogenesis. (1979) (20)
SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation* (2013) (20)
Cell cycle 'check points' T cell anergy (2006) (19)
Association of a 70-kDa tyrosine phosphoprotein with the CD16: zeta: gamma complex expressed in human natural killer cells. (1993) (19)
Isoelectric focusing of bovine major histocompatibility complex class II molecules (1989) (18)
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates anti-tumor immune responses. (2021) (18)
A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells (1992) (18)
Association of T cell antigen CD7 with type II phosphatidylinositol‐4 kinase, a key component in pathways of inositol phosphate turnover (2003) (17)
Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells. (1993) (17)
A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade (2020) (17)
Hematopoietic Adaptors in T‐Cell Signaling: Potential Applications to Transplantation (2003) (16)
SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering (2010) (16)
A 72-kilodalton fyn-related polypeptide (p72fyn-R) binds to the antigen-receptor/CD3 (TcR/CD3) complex. (1993) (16)
TcR zeta/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB. (1997) (16)
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity (2019) (15)
Lymphocyte signaling: Adapting new adaptors (1998) (15)
Adaptor SKAP-55 Binds p21ras Activating Exchange Factor RasGRP1 and Negatively Regulates the p21ras-ERK Pathway in T-Cells (2008) (15)
Human CD4/CD45RA+ and CD4/CD45RA- T cell subsets express CD4-p56lck complexes, CD4-associated lipid kinases, TCR/CD3-p59fyn complexes, and share similar tyrosine kinase substrates. (1993) (14)
Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy (2020) (14)
Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA‐4 to a positive signaling receptor (2003) (13)
Mechanisms of CD28 signalling. (1995) (13)
Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines (2017) (12)
Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells (2019) (12)
SKAP1 is dispensable for chemokine-induced migration of primary T-cells (2010) (11)
Glycogen synthase 3 (GSK-3) regulation of PD-1 expression and and its therapeutic implications. (2019) (11)
Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand (2015) (11)
Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells (2019) (10)
T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice (2016) (9)
How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy (2021) (9)
Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells (2019) (9)
CTLA-4 regulation of T cell function via RAP-1-mediated adhesion. (2006) (8)
Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy. (2019) (8)
Effective chimeric antigen receptor T cells against SARS-CoV-2 (2021) (8)
Thymidine transport in human lymphocytes stimulated with concanavalin A: effect of colchicine. (1981) (7)
Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1 (2016) (7)
Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase). (1993) (7)
Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988. (2010) (6)
Pillars Article: The CD4 Receptor Is Complexed in Detergent Lysates to a Protein-Tyrosine Kinase (Pp58) from Human T Lymphocytes. Proc. Natl. Acad. Sci. USA 1988. 85: 5190–5194 (2010) (6)
Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region (2018) (6)
The Expression of HLA-DR, DQ and DP Antigens on the Surface of Lymphocytes as Assessed by 2-D Polyacrylamide Gel Analysis of Immunoprecipitates (1984) (6)
CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells (2016) (6)
SLP-76 sterile alpha motif (SAM) and individual H5 alpha helix mediates oligomer formation for microclusters and T-cell activation (2013) (6)
Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy (2021) (5)
SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells (2016) (5)
Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen. (1989) (5)
Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection (2021) (5)
Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors (2013) (5)
Cytotoxic T Lymphocyte Antigen 4 and CD 28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function (2001) (5)
CD28 family of receptors inter-connect in the regulation of T-cells (2017) (4)
Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells (2015) (4)
Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases (2022) (3)
Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory (2021) (3)
Characterisation of the HLA-D Region DQw3 Specificity Using the Monoclonal Antibodies 2HB6 and IVD12 (1984) (3)
Commentary: Small Molecule Inhibition of PD-1 Transcription is an Effective Alternative to Antibody Blockade in Cancer Therapy (2019) (3)
Physiological and aberrant regulation of memory T cell trafficking by the co- stimulatory molecule CD28. Running title: Regulation of memory T cell trafficking by CD28 (2006) (3)
Src-related kinases and their receptors (1995) (2)
CD 5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor C chain / CD 3 and protein-tyrosine kinases p 561 ck and p 59 fif ( signal transduction / CDS ) (2)
Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines (2022) (2)
Correction: CTLA-4 Activation of Phosphatidylinositol 3-Kinase (PI 3-K) and Protein Kinase B (PKB/AKT) Sustains T-Cell Anergy without Cell Death (2009) (2)
Advances in T-cell co-receptor biology and cancer immunotherapy. (2019) (2)
Abstract 6528: Anti-PD-1 induces the endocytosis of the co-receptor from the surface of T-cells: Nivolumab is more effective than Pembrolizumab (2020) (2)
Distinct NF-κB activation pathways engaged by T-cell receptor and co-receptor CD 28 on T-cells (2015) (1)
In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics (2022) (1)
Small Molecule Inhibition of Glycogen Synthase Kinase 3 (GSK-3) Specifically Inhibits the Transcription of Inhibitory Co-Receptor LAG-3 for Enhanced Anti-Tumor Immunity (2019) (1)
A Raf-1-Related pllO Polypeptide Associates with the CD 4p 56 lck Complex in T Cells (1)
LYMPHOKINE REGULATION OF CD 45 R EXPRESSION ON HUMAN T CELL CLONES (2003) (1)
Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report (2020) (1)
CD28 and glycogen synthase kinase-3 (GSK-3) inhibitor combination therapy generates tumor infiltrating T-cells (TILs) with a reversal of markers for T-cell exhaustion (2020) (1)
T-cell signaling and immunopathologies (2010) (1)
Glycosylation and biosynthesis of human HLA-D region antigen-associated invariant polypeptides (1984) (1)
Targeting EGFR, RSK1, RAF1, PARP2 and LIN28B for several cancer type therapies with newly synthesized pyrazole derivatives via a computational study. (2022) (1)
Dynamical and mechanistic reconstructive approaches of T lymphocyte dynamics: using visual modeling languages to bridge the gap between immunologists, theoreticians, and programmers (2013) (1)
Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment. (2022) (1)
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD 8 + Cytolytic T Cell Responses Graphical (2016) (1)
Glycogen synthase kinase 3 (GSK-3) synergizes with immune-checkpoint blockade (ICB) to overcome tumor resistance due to unique tumor infiltrating T-cell subsets as revealed by mass cytometry (CyTOF) (2019) (1)
Biochemical analyses of human class II histocompatibility (HLA-D region) antigen- associated invariant polypeptides (1984) (0)
Glycogen synthase kinase-3 (GSK-3) inactivation compensates for the lack of CD28 in the priming of CD8+ cytotoxic T-cells: Implications for anti-PD-1 immunotherapy (2018) (0)
Non-Redundant Activity of GSK-3α and GSK-3β in T Cell-Mediated Tumour Rejection (2021) (0)
Erratum (2005) (0)
Glycogen synthase kinase (GSK-3) synergizes with PD-1/PDL1 blockade to generate super-armed CD8 killers against tumors (2022) (0)
Cell adhesion in immunity (WS-103) Chairpersons: Tatsuo Kinashi, Sirpa Jalkanen (2010) (0)
Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors (2013) (0)
and Myosin Light Chain Kinase Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, Rapid T Cell Polarization That Depends on CTL-Associated Antigen-4 Ligation Induces (2007) (0)
Co-Receptors in the Positive and Negative Regulation of T-Cell Immunity (2008) (0)
SLP-76 Binding to FYB at Tyr TCR-Driven IL-2 Transcription Requires FYB / FYN-T in the Up-Regulation of Cutting Edge : SLP-76 Cooperativity with (1999) (0)
Receptor (TCR) Activation of LFA-1 Protein Complex Formation for T Cell RapL Membrane Localization and Rap1 SKAP1 Protein PH Domain Determines Immunology: (2014) (0)
Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity (2021) (0)
Glycogen synthase kinase 3 (GSK-3) controls T-cell motility andinteractions with antigen presenting cells (2020) (0)
GTPase-activating protein (RASAL1) associates with ZAP-70 of the TCR and negatively regulates T-cell proliferation and anti-tumor immunity (2019) (0)
Effective chimeric antigen receptor T-cells (CAR-Ts) against SARS-CoV-2 (2021) (0)
Colchicine, microtubules, thymidine transport and lymphocyte function. (1980) (0)
Functional Defects of SKAP-55-Deﬁcient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion (cid:1) (2007) (0)
Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells (2019) (0)
Small molecules that inhibit PD-1 transcription is as effective as anti-PD-1/PL1 biologics in immunotherapy (2018) (0)
Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region (2018) (0)
The molecular mechanisms of regulatoryT cell immunosuppression (2011) (0)
Editorial: T-Cell Signaling Networks in Health and Disease (2022) (0)
ADAP-SLP-76 binding regulates supramolecular activation cluster (SMAC) formation and interleukin-2 production (2004) (0)
The Association of p 56 lck with the CD 4 / CD 8 Antigens : Implications for T-Cell Function (0)
Function Inhibit and Costimulate Human T Cell Adhesion Molecule 1 Isoforms Alternatively Carcinoembryonic Antigen-Related Cellular (2004) (0)
Co-stimulation and cell communication (SY4-5) Chairpersons: Hitoshi Kikutani, Carola Vinuesa (2010) (0)
Abstract 1696: Glycogen synthase kinase (GSK-3) inactivation downregulates PD-1 and synergizes with PD-1/PL1 and CTLA-4 blockade in cancer immunotherapy (2018) (0)
2D-QSAR study and design of novel pyrazole derivatives as an anticancer lead compound against A-549, MCF-7, HeLa, HepG-2, PaCa-2, DLD-1 (2023) (0)
Dynamics of sub-synaptic vesicles and surface microclusters at the T cell immunological synapse (2010) (0)
Adaptors TRIM and LAX regulate transport and surface expression of co-receptor CTLA-4 on T-cells (2012) (0)
Transduction de signaux par l'intermediaire de cd28 (1994) (0)
The Association of p56 lck with the CD4/CD8 Antigens: Implications for T-Cell Function (1989) (0)
Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade (2022) (0)
Hydroxychloroquine (HCQ) reverses anti-PD-1 immune murine checkpoint blockade: TCF1 as a marker in humans for COVID-19 and HCQ therapy (2020) (0)
B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling (2020) (0)
A novel SLP-76 signaling pathway T-cells that controls cancer immunotherapy (2021) (0)
Small molecule drug inhibition of PD-1 transcription is as effective as anti-PD-1 biologic blockade in cancer therapy (2017) (0)
Abstract A59: Inhibition of Glycogen Synthase Kinase 3 (GSK-3) synergizes with anti-PD-1 by potentiating tumor-infiltrated CD8+ T-cells (2020) (0)
Small Molecule Inhibitors as an Alternative to Antibody Blockade in Immunotherapy (2019) (0)
SLP-76 Adaptor Binding to SUMO-RANGAP1 of the Nuclear Pore Complex Regulates Multiple Aspects of T-cell Immunity (2017) (0)
Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells (2020) (0)

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