Christopher G. Tate
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British chemist
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Chemistry
Christopher G. Tate's Degrees
- Bachelors Chemistry University of Oxford
- PhD Chemistry University of Oxford
Why Is Christopher G. Tate Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christopher G. Tate FRS is an English membrane protein biochemist and molecular biologist who works at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK. Tate is known for his contributions to the understanding of G protein-coupled receptors.
Christopher G. Tate's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular signatures of G-protein-coupled receptors (2013) (1299)
- Structure of a β1-adrenergic G-protein-coupled receptor (2008) (1200)
- Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation (2011) (807)
- The structural basis for agonist and partial agonist action on a β1-adrenergic receptor (2010) (617)
- Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. (2011) (494)
- Structure of the agonist-bound neurotensin receptor (2012) (460)
- Conformational thermostabilization of the β1-adrenergic receptor in a detergent-resistant form (2008) (435)
- Overexpression of integral membrane proteins for structural studies (1995) (383)
- Overcoming barriers to membrane protein structure determination (2011) (378)
- Structure of the adenosine A2A receptor bound to an engineered G protein (2016) (340)
- Universal allosteric mechanism for Gα activation by GPCRs (2015) (246)
- Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region (2016) (232)
- Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol (2012) (222)
- Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor (2008) (218)
- Three‐dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer (2003) (215)
- The effect of N-linked glycosylation on activity of the Na(+)- and Cl(-)-dependent serotonin transporter expressed using recombinant baculovirus in insect cells. (1994) (209)
- Two distinct conformations of helix 6 observed in antagonist-bound structures of a β1-adrenergic receptor (2011) (200)
- Overexpression of mammalian integral membrane proteins for structural studies (2001) (191)
- Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells (2018) (184)
- Engineering G protein-coupled receptors to facilitate their structure determination. (2009) (184)
- Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein (2018) (170)
- Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition. (1996) (168)
- The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor (2014) (167)
- Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions (2009) (165)
- Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go (2018) (164)
- Thermostabilisation of the neurotensin receptor NTS1 (2009) (159)
- PIP2 stabilises active states of GPCRs and enhances the selectivity of G-protein coupling (2018) (153)
- Biophysical Fragment Screening of the β1-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design (2013) (151)
- Impact of GPCR Structures on Drug Discovery (2020) (142)
- Heterologous expression of G-protein-coupled receptors. (1996) (141)
- Mini-G proteins: Novel tools for studying GPCRs in their active conformation (2017) (139)
- Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter. (2003) (136)
- Partitioning of the Serotonin Transporter into Lipid Microdomains Modulates Transport of Serotonin* (2004) (136)
- A crystal clear solution for determining G-protein-coupled receptor structures. (2012) (132)
- Thermostabilisation of an Agonist-Bound Conformation of the Human Adenosine A2A Receptor (2011) (131)
- The projection structure of EmrE, a proton‐linked multidrug transporter from Escherichia coli, at 7 Å resolution (2001) (131)
- Preferential expression of the complement regulatory protein decay accelerating factor at the fetomaternal interface during human pregnancy. (1990) (129)
- Quasi-symmetry in the cryo-EM structure of EmrE provides the key to modeling its transmembrane domain. (2006) (121)
- Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor (2015) (120)
- Practical considerations of membrane protein instability during purification and crystallisation. (2010) (116)
- Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor (2020) (109)
- Three-Dimensional Structure of TspO by Electron Cryomicroscopy of Helical Crystals (2010) (105)
- Development and crystallization of a minimal thermostabilised G protein-coupled receptor. (2009) (104)
- The Escherichia coli multidrug transporter EmrE is a dimer in the detergent-solubilised state. (2004) (101)
- Agonist-bound structures of G protein-coupled receptors. (2012) (101)
- Overexpression of membrane proteins in mammalian cells for structural studies (2012) (101)
- Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation (2016) (98)
- Molecular Chaperones Stimulate the Functional Expression of the Cocaine-sensitive Serotonin Transporter* (1999) (91)
- Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6 (2007) (87)
- A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies (2016) (86)
- Conformational changes in the multidrug transporter EmrE associated with substrate binding. (2003) (83)
- Cryo-EM structures of GPCRs coupled to Gs, Gi and Go (2019) (79)
- Outrunning free radicals in room-temperature macromolecular crystallography (2012) (78)
- Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor (2017) (76)
- Molecular basis for high-affinity agonist binding in GPCRs (2018) (68)
- Cryo-Electron Microscopy: Moving Beyond X-Ray Crystal Structures for Drug Receptors and Drug Development. (2020) (67)
- Calreticulin Promotes Folding/Dimerization of Human Lipoprotein Lipase Expressed in Insect Cells (Sf21)* (2003) (66)
- PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling (2018) (66)
- Drug binding revealed by tandem mass spectrometry of a protein-micelle complex. (2004) (66)
- How Can Mutations Thermostabilize G-Protein-Coupled Receptors? (2016) (62)
- Pharmacology and Structure of Isolated Conformations of the Adenosine A2A Receptor Define Ligand Efficacy (2013) (62)
- Engineering an ultra-thermostable β(1)-adrenoceptor. (2011) (59)
- Transferability of thermostabilizing mutations between β-adrenergic receptors (2009) (59)
- Small is mighty: EmrE, a multidrug transporter as an experimental paradigm. (2001) (58)
- Electron Crystallography Reveals Plasticity within the Drug Binding Site of the Small Multidrug Transporter EmrE (2008) (56)
- Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces. (2017) (54)
- Quality Control in Eukaryotic Membrane Protein Overproduction (2014) (53)
- Calnexin co-expression and the use of weaker promoters increase the expression of correctly assembled Shaker potassium channel in insect cells. (2003) (50)
- Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity (2018) (49)
- New insights into the structure and oligomeric state of the bacterial multidrug transporter EmrE: an unusual asymmetric homo‐dimer (2004) (48)
- A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization (2011) (47)
- High‐throughput screening and selection of mammalian cells for enhanced protein production (2016) (46)
- Mapping, cloning, expression, and sequencing of the rhaT gene, which encodes a novel L-rhamnose-H+ transport protein in Salmonella typhimurium and Escherichia coli. (1992) (45)
- An emerging consensus for the structure of EmrE (2009) (43)
- Comparison of three structures of the multidrug transporter EmrE. (2006) (43)
- Studies on the defect which causes absence of decay accelerating factor (DAF) from the peripheral blood cells of an individual with the Inab phenotype. (1989) (41)
- Identification of a novel sugar‐H+ symport protein, FucP, for transport of L‐fucose into Escherichia coli (1994) (41)
- Optimising the combination of thermostabilising mutations in the neurotensin receptor for structure determination. (2013) (39)
- Structure of the class D GPCR Ste2 dimer coupled to two G proteins (2020) (35)
- GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 (2015) (35)
- Thermostabilisation of the Serotonin Transporter in a Cocaine-Bound Conformation (2013) (33)
- How Do Short Chain Nonionic Detergents Destabilize G-Protein-Coupled Receptors? (2016) (32)
- The Molecular Control of Calcitonin Receptor Signaling. (2019) (31)
- Proton-linked L-rhamnose transport, and its comparison with L-fucose transport in Enterobacteriaceae. (1993) (30)
- Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors (2014) (28)
- Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins α and δ (1988) (28)
- Structural Dynamics and Thermostabilization of Neurotensin Receptor 1 (2015) (28)
- Dynamic Behavior of the Active and Inactive States of the Adenosine A2A Receptor (2014) (25)
- The Emery–Dreifuss muscular dystrophy associated‐protein emerin is phosphorylated on serine 49 by protein kinase A (2006) (25)
- Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol–Bound β1-Adrenergic Receptor (2015) (23)
- Membrane topology of the L-rhamnose-H+ transport protein (RhaT) from enterobacteria. (1993) (23)
- Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor (2019) (22)
- Biophysical Characterization of the Cocaine Binding Pocket in the Serotonin Transporter Using a Fluorescent Cocaine Analogue as a Molecular Reporter* (2001) (22)
- Studies on human red-cell membrane glycophorin A and glycophorin B genes in glycophorin-deficient individuals. (1989) (20)
- How Do Branched Detergents Stabilize GPCRs in Micelles? (2020) (20)
- The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands. (2013) (20)
- Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome (2013) (20)
- Identification of an Alternating-Access Dynamics Mutant of EmrE with Impaired Transport (2019) (19)
- The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor (2011) (19)
- Preface: overexpression of integral membrane proteins (2003) (19)
- Erratum: Structure of the adenosine A2A receptor bound to an engineered G protein (2016) (19)
- Topological analyses of the l‐fucose‐H+ symport protein, FucP, from Escherichia coli (1995) (18)
- Structure of the adenosine A(2A) receptor bound to an engineered G protein (vol 536, pg 104, 2016) (2016) (17)
- Expression and Purification of Mini G Proteins from Escherichia coli. (2017) (16)
- Thermostabilization of the β1-adrenergic receptor correlates with increased entropy of the inactive state. (2013) (15)
- Baculovirus-mediated expression of neurotransmitter transporters. (1998) (13)
- Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support (2016) (13)
- Molecular Determinants of CGS 21680 Binding to the Human Adenosine A 2 A Receptor s (2015) (13)
- Ligand occupancy in crystal structure of β1-adrenergic G protein–coupled receptor (2015) (13)
- Structure determination of GPCRs: cryo-EM compared with X-ray crystallography (2021) (12)
- Expression, Purification and Crystallisation of the Adenosine A2A Receptor Bound to an Engineered Mini G Protein. (2017) (12)
- Molecular chaperones improve functional expression of the serotonin (5-hydroxytryptamine) transporter in insect cells. (1999) (10)
- Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta. (1988) (8)
- Strategy for the Thermostabilization of an Agonist-Bound GPCR Coupled to a G Protein. (2017) (8)
- Machine Learning for Prioritization of Thermostabilizing Mutations for G-protein Coupled Receptors (2019) (8)
- Differences in SMA-like polymer architecture dictate the conformational changes exhibited by the membrane protein rhodopsin encapsulated in lipid nano-particles (2021) (7)
- Activation mechanism of the class D fungal GPCR dimer Ste2 (2022) (7)
- Membrane Protein Gymnastics (2010) (7)
- Generation of Tetracycline-Inducible Mammalian Cell Lines by Flow Cytometry for Improved Overproduction of Membrane Proteins. (2016) (6)
- Isolation and characterisation of transport-defective substrate-binding mutants of the tetracycline antiporter TetA(B) (2015) (6)
- Growth and excitement in membrane protein structural biology. (2010) (5)
- High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs (2021) (5)
- Advances in membrane protein crystallography: in situ and in meso data collection (2015) (4)
- Purification and Crystallization of a Thermostabilized Agonist-Bound Conformation of the Human Adenosine A(2A) Receptor. (2015) (3)
- Molecular determinants of β-arrestin coupling to formoterol-bound β1-adrenoceptor (2020) (3)
- [Structure of the adenosine-bound conformation of the human adenosine A(2A) receptor]. (2011) (3)
- [G protein-coupled receptors in the spotlight]. (2012) (3)
- Structural biology: A receptor that might block itself (2017) (3)
- Structure of the class D GPCR Ste2 dimer coupled to two G proteins (2020) (3)
- WIDENING BOTTLENECKS IN MEMBRANE PROTEIN STRUCTURE PIPELINES (2012) (2)
- Cryo-EM structure of the adenosine A 2 A receptor coupled to an engineered 3 heterotrimeric G protein 4 5 6 (2018) (2)
- How do mutations thermostabilize G protein-coupled receptors? (2016) (2)
- Ligand occupancy in crystal structure of beta1-adrenergic receptor previously submitted by Huang et al (2015) (2)
- Molecular basis for high affinity agonist binding in GPCRs (2018) (2)
- The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13) (2012) (1)
- Identifying Thermostabilizing Mutations in Membrane Proteins by Bioinformatics. (2015) (1)
- Membrane Protein Structure Determination by Electron Cryo‐Microscopy (2008) (1)
- A feast of membrane protein structures in Madrid (2001) (1)
- Editorial overview: New constructs and expression of proteins: Making things better. (2014) (1)
- Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor (2017) (1)
- Thermostabilised HUMAN A2a Receptor with NECA bound (2011) (0)
- Developing novel antifungals: lessons from G protein-coupled receptors. (2023) (0)
- Engineering GPCRs for Improved Thermostability to Facilitate Structure Determination (2015) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL (2008) (0)
- Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc. (2020) (0)
- GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 (2015) (0)
- Mutant membrane proteins and methods for their production (2014) (0)
- The Holy Grail realized: Structure-based drug design applied to GPCRs (2014) (0)
- New insights into GPCR coupling and dimerisation from cryo-EM structures. (2023) (0)
- Conformational thermostabilisation of integral membrane proteins and structure determination (2010) (0)
- Thermostabilised adenosine A2A receptor in complex with caffeine (2011) (0)
- Insights into the Stability of GPCRs in Detergent Micelles (2016) (0)
- Controlling the Rate and Efficiency of Proton-Coupled Transport by EmrE (2020) (0)
- Activation mechanism of the class D fungal GPCR dimer Ste2 (2022) (0)
- A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex (2019) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102) (2011) (0)
- Thermostabilised turkey beta1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound (compound 19) (2013) (0)
- Mutant beta-adrenergic receptors with improved stability (2008) (0)
- ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY Nb6B9 (2018) (0)
- Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance antiporter from E. coli EmrE (2006) (0)
- ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY Nb6B9 (2018) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL (2011) (0)
- Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol (2012) (0)
- Microsoft Word-31090775-file00.docx (2015) (0)
- Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization (2020) (0)
- Machine Learning Methods for Rapid Prediction of Thermostabilizing Mutants of G‐protein‐coupled receptors in Detergents (2018) (0)
- Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound (2013) (0)
- Stable adenosine receptor mutants (2008) (0)
- cDNA cloning of human erythrocyte membrane proteins and studies of abnormal blood group phenotypes. (1989) (0)
- ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80 (2018) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL (2011) (0)
- Thermostabilised HUMAN A2a Receptor with adenosine bound (2011) (0)
- Thermostabilised HUMAN A2a Receptor with CGS21680 bound (2015) (0)
- Mutant G-protein-coupled receptors, and methods for the selection thereof (2008) (0)
- Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound (2014) (0)
- thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound (2015) (0)
- SERT biosynthesis and the problems of overexpression for structural studies (2001) (0)
- Dynamic Behaviors of Various Conformational States of A2A Receptor (2018) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL (2011) (0)
- Emerin is phosphorylation on serine 49 by protein kinase A (2006) (0)
- Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor (2018) (0)
- Crystal structure of the rhodopsin-mini-Go complex (2018) (0)
- Thermostabilised Adenosine A2A Receptor (2011) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE (2011) (0)
- Mutant g-protein coupled receptors with increased conformational stability and methods for producing them (2008) (0)
- Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go (2018) (0)
- Insights into How Mutations Thermostabilize G-Protein-Coupled Receptors (2016) (0)
- Expression and Purification of the Human Thyroid-Stimulating Hormone Receptor. (2022) (0)
- G protein coupled receptors and methods of selecting mutants (2008) (0)
- Mutant adenosine receptors with improved stability (2008) (0)
- Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins a and 6 (2005) (0)
- Thermostabilised adenosine A2A receptor in complex with XAC (2011) (0)
- ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY Nb80 (2018) (0)
- Mutant G-protein coupled receptor proteins and methods for selecting them (2008) (0)
- ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY Nb6B9 (2018) (0)
- Mutant muscarinic receptors with increased stability (2008) (0)
- ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9 (2018) (0)
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